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True To Size: Creating An Interdisciplinary Suicide Awareness And Prevention Evidence-Based Project In A Nonprofit Academic Medical Center, Darci Martinez

Doctoral Scholarly Projects & Capstones

Suicide is a serious health problem that continues to increase despite significant efforts to reduce suicide in vulnerable populations. High rates of suicide negatively impact individuals, families, and communities nationwide. The purpose of this project was to prepare the inpatient and outpatient clinical workforce at National Jewish Health (NJH) to care for patients who are suicidal. This project included reviewing the literature on suicide awareness and prevention training across the continuum of healthcare, implementing an evidence-based training model, and evaluating the effectiveness of training. This project started in 2017 and throughout, this researcher was the lead for the Suicide Prevention …

Effect Of Training Phase On Physical And Physiological Parameters Of Male Powerlifters, Daniel A. Hackett, Guy C. Wilson, Lachlan Mitchell, Marjan Mosalman Haghighi

Open Access archive

Longitudinal research on training and dietary practices of natural powerlifters is limited. This study investigated the effect of phases of training on physical and physiological parameters in male natural powerlifters. Nine participants completed testing at two time points: (i) preparatory phase (~3 months prior to a major competition) and (ii) competition phase (1–2 weeks from a major competition). No significant changes between training phases were found for muscle strength and power. A trend for significance was found for decreased muscle endurance of the lower body (−24.4%, p = 0.08). A significant increase in leg lean mass was found at the …

The Criminal Justice Response To The Opioid Crisis In East Baton Rouge Parish, Elizabeth Winchester, Kristina Little, Timothy T. Reling, Gabriele Richardson, Judith F. Rhodes

Reports

This report describes: 1) the history and current state of the opioid crisis in East Baton Rouge Parish; 2) the current and planned efforts of the Innovative Prosecution Solutions for Combating Violent Crime and Illegal Opioids (IPS) grant to respond to the crisis; and 3) recommendations for criminal justice practitioners regarding the opioid crisis in our community. The goal of the IPS grant is to reduce opioid-related deaths by fostering interagency collaboration to disrupt local opioid supply chains, educate the community about the dangers of opioid abuse and addiction, and provide support for individuals with opioid use disorder.

The rising …

Role Of Cyp2b6 In Perfluorooctanesulfonic Acid (Pfos)-Induced Toxicity And Non Alcoholic Fatty Liver Disease (Nafld), Matthew C. Hamilton

All Theses

Perfluorooctanesulfonic acid (PFOS) is a persistent, toxic fluorosurfactant foam used in firefighting foams, textiles, and other industrial products. Human CYP2B6 is predominantly expressed in the liver and responsible for metabolizing xeno- and endobiotics. CYP2B is induced by PFOS and high-fat diets in rodents and therefore it was hypothesized that CYP2B contributed to PFOS-induced steatosis. Cyp2b-9/10/13-null (Cyp2b-null) and humanized CYP2B6-Tg (hCYP2B6-Tg) mice were treated with PFOS (0, 1, or 10 mg/kg/day) by oral gavage in mice fed either a typical chow diet (ND) or a high-fat diet (HFD). Our studies show human CYP2B6 is also inducible in vivo by PFOS. In …

Tissue-Resident Myeloid-Derived Suppressor Cells Modulate Immune Homeostasis In Healthy Adipose., Katlin Brooke Stivers

Electronic Theses and Dissertations

Our goal with this study was to gain insight into the homeostatic immune cell network in healthy adipose tissue. Specifically, we sought to determine if the immature myeloid cells found in healthy and inflamed adipose were, in fact, tissue-resident myeloid-derived suppressor cells (MDSCs). Using various in vitro and in vivo methods, we have uncovered a population of CD11b^Hi Ly6C^Hi Ly6G^- MDSCs resident in healthy adipose tissue. To the best of our knowledge this is the first time that these cells have been investigated and described in healthy adipose tissue. Systemic MDSC depletion lead to the accumulation of …

Plasmodium Impairs Antibacterial Innate Immunity To Systemic Infections In Part Through Hemozoin-Bound Bioactive Molecules., Christopher Lynn Harding

Electronic Theses and Dissertations

Despite efforts to decrease the global health burden of malaria, infections with Plasmodium species continue to cause over 200 million episodes of malaria each year which resulted in 405,000 deaths in 2018 [1]. One complication of malaria is increased susceptibility to invasive bacterial infections. Plasmodium infections impair host immunity to non-Typhoid Salmonella (NTS) through activities of heme oxygenase I (HO-I) )-induced release of immature granulocytes and myeloid cell-derived IL-10. Yet, it is not known if these mechanisms are specific to NTS. We show here, that Plasmodium yoelii 17XNL (Py) infected mice had impaired clearance of systemic Listeria monocytogenes (Lm) during …

Identification And Structural Characterization Functional Motifs In The Porphyromonas Gingivalis Mfa1 Short Fimbria., Mohammad K. Roky

Electronic Theses and Dissertations

Porphyromonas gingivalis is a causative agent of periodontal disease, initially colonizes the oral cavity by adhering to commensal streptococci. Adherence requires the interaction of the minor fimbrial protein (Mfa1) of P. gingivalis with streptococcal antigen I/II (Ag I/II). A peptide derived from Ag I/II peptide has been well characterized and shown to significantly reduce P. gingivalis colonization and bone loss in vivo, suggesting that this interaction represents a potential target for therapeutic intervention. However, the functional motifs of Mfa1 involved in the interaction with Ag I/II remain uncharacterized. A series of N- and C-terminal peptide fragments of Mfa1 were …

Characterization Of Human Pyrroline-5-Carboxylate Reductase Enzymes Responsible For L-Proline Biosynthesis, Sagar Patel

Department of Biochemistry: Dissertations, Theses, and Student Research

Pyrroline-5-carboxylate reductases (EC 1.5.1.2) are important housekeeping enzymes of L-proline biosynthesis, which generate L-proline and influence redox cycling of NAD(P)H/NAD(P)⁺ to support cellular growth in all domains of life. Structural evidence from X-ray crystal structures of HsPYCR1 (PDB codes 5UAT, 5UAU, and 5UAV) shows both NADPH bound in the N-terminal Rao-Rossmann fold motif and an important hydrogen bond or proton donor role for Thr238 with L-P5C. The Thr238Ala mutation results in 10-fold loss in catalytic efficiency with varied L-P5C relative to the wild-type enzyme, thus indicating Thr238’s potential hydrogen bond and proton donation to L-P5C is critical for catalysis. …

Molecular Diagnosis Of Intestinal Parasites: Impact On Growth Among Preschool-Age Children In Rural Ecuador, Patricia Bryan

Dissertations and Theses (Open Access)

Background: Gastrointestinal (GI) parasites may have important influences on growth outcomes during early childhood. Previous studies investigating the effects of GI parasites on growth have predominantly used microscopy-based diagnostic methods with low sensitivity. Few accurate epidemiologic data are available on GI parasitic infections among rural Ecuadorian children. To investigate the impact of single and multiple GI parasite infections on growth during early childhood data from a longitudinal birth cohort in Ecuador were analyzed.

Purpose: The aims of this study were to determine the prevalence of GI parasites (soil-transmitted helminths and intestinal protozoa) and to describe associations between GI parasitic infections …

Area-Level Landfill Density And Asthma Prevalence In Urban Texas Areas, Jessica Meighan Herrin

Dissertations and Theses (Open Access)

Environmental exposures, especially air pollutants, pose a threat for an increase in asthma prevalence. In particular, hydrogen sulfide (H2S) gas can cause severe health effects closely resembling asthmatic symptoms. Ambient concentrations of H2S gas correlates with the amount of solid waste found in landfills. The potential for adverse health risks associated with H2S emitted from landfills is of concern for those populations living in close proximity to landfills. Asthma is one of the adverse health effects that can occur due to H2S exposure. However, there is a lack of detailed studies characterizing possible associations between the density of landfills and …

The Multilevel Factors Facilitating Or Impeding Healthcare Access Among Refugees Residing In Bexar County Texas, Howaida Werfelli

Dissertations and Theses (Open Access)

The goal of this study was to increase understanding of healthcare access among refugees by investigating the multilevel factors that facilitate or impede healthcare access among refugees who have resettled in Bexar County, Texas. The multilevel factors facilitating or impeding access to healthcare for refugees resettled in Bexar County were identified as follows: health literacy, level of educational attainment, proficiency (reading, writing and, speaking) in English, proficiency (reading, writing and speaking) in native language, translation services, public transportation, income level, a shortage of healthcare providers, navigation of the healthcare system, the fragmentation of the healthcare system, insurance status, staff shortages …

Mathematical Modeling Of Scavengers And Zebras On The African Savanna With Disease Dynamics, Crystal Dawn Mackey

Mathematics Dissertations - Archive

The purpose of this dissertation is to use mathematical models to see how anthrax in the zebra population in Etosha National Park (ENP) interacts with scavenger populations and disease dynamics. First, we study if scavengers can save zebras from anthrax. Then we introduce a disease in the jackal population to see if anthrax in zebras can help propagate rabies in jackals. Finally, the last two models we develop describe the interaction between competing scavengers: jackals and vultures, with exploitative and interference competition. ENP is home to many different animals such as lions, jackals, hyenas, zebras, elephants, etc. Each year grazing …

A Phenomenological Study Of Rural Elementary Principals In Western And Central New York Perceptions Of Isolation, Bonnie Cazer

Education Doctoral

The purpose of this transcendental phenomenological study was to develop an understanding of rural elementary principals’ perceptions of isolation. This study posed the question: In what ways do rural elementary principals in Western and Central New York perceive isolation? The research design included semi-structured interviews of a purposeful sample of five rural elementary principals in Western and Central New York. This study utilized the theoretical framework of Ryan and Deci’s (2018) relationship motivation theory. Six themes emerged through transcendental phenomenological analysis: distance divides, power of networks, outsider syndrome, relationships are the foundation, wearing many hats, and building know how. Findings …

Inverse Problems For Polynomial And Rational Matrices, Richard Allen Hollister

Dissertations

Inverse problems have long been studied in mathematics not only because there are many applications in science and engineering, but also because they yield new insight into the beauty of mathematics. Central to the subject of linear algebra is the eigenvalue problem: given a matrix, and its eigenvalues (numerical invariants). Eigenvalue problems play a key role in almost every field of scientific endeavor from calculating the vibrational modes of a molecule to modeling the spread of an infectious disease, and so have been studied extensively since the time of Euler in the 18th century.

If a typical matrix eigenvalue problem …

Analysis Of Bacterial Loads In Houston Indoor Air., Zeest Hanif Hanif

Theses (2016-Present)

House dust is a complex matrix containing organic and inorganic content with a good percentage of microorganisms. Microorganism’s growth and survival in dust depends on available moisture level. Microbial origin in dust depends on sources other than dust. On average people spend approximately 90% of their time in indoor environment. Therefore, they are continuously exposed to microbes in dust. Based on the size and volume of dust particles the microbes get access to human lungs via airways. Based on previous research; culture dependent studies indicate that Penicillium, Aspergillus, Cladosporium are in abundance is house dust along with 20 other fungal …

Learning From Chemical Coping Behaviors Of Wildlife To Discover New Approaches For Pest Management, Britt Pendleton

Boise State University Theses and Dissertations

Pests, such as parasites and pathogens, persist throughout time and space as threats to public health and food security. The need for novel and sustainable approaches to managing these threats are in high demand. The current approach of discovering and developing chemical treatments to manage pests is tedious, not efficient, and often outpaced by traits of resistance in pests. Here, we propose a new approach to discovering new chemical pest management solutions by observing chemical coping behaviors in wildlife. We define a chemical coping behavior as the exploitation of naturally occurring chemicals within a host’s environment to manage pests. Specifically, …

Traffic Impacts Of The Covid-19 Pandemic: Statewide Analysis Of Social Separation And Activity Restriction, Scott Parr, Brian Wolshon, John Renne, Pamela Murray-Tuite, Karl Kim

Faculty Publications

The COVID-19 pandemic resulted in significant social and economic impacts throughout the world. In addition to the health consequences, the impacts on travel behavior have also been sudden and wide ranging. This study describes the drastic changes in human behavior using the analysis of highway volume data as a representation of personal activity and interaction. Same-day traffic volumes for 2019 and 2020 across Florida were analyzed to identify spatial and temporal changes in behavior resulting from the disease or fear of it and statewide directives to limit person-to-person interaction. Compared to similar days in 2019, overall statewide traffic volume dropped …

Avoiding Covid-19 Complications With Diabetic Patients Could Be Achieved By Multi-Dose Bacillus Calmette–Guérin Vaccine: A Case Study Of Beta Cells Regeneration, Bassam M. Ayoub, Eman Ramadan, Nermeen Ashoush, Mariam M. Tadros, Moataz S. Hendy, Mohamed M. Elmazar, Shaker A. Mousa

Pharmacy

Diabetes mellitus (DM) is one of the major risk factors for COVID-19 complications as it is one of the chronic immune-compromising conditions especially if patients have uncontrolled diabetes, poor HbA1c and/or irregular blood glucose levels. Diabetic patients' mortality rates with COVID-19 are higher than those of cardiovascular or cancer patients. Recently, Bacillus Calmette-Guérin (BCG) vaccine has shown successful results in reversing diabetes in both rats and clinical trials based on different mechanisms from aerobic glycolysis to beta cells regeneration. BCG is a multi-face vaccine that has been used extensively in protection from tuberculosis (TB) and leprosy and has been repositioned …

Jewish Holidays In The Time Of The Corona Virus Pandemic In Slovakia, Peter Salner

Occasional Papers on Religion in Eastern Europe

The first wave of the new coronavirus pandemic swept through Slovakia between March 1 and May 31, 2020. During this relatively short period, four important Jewish holidays took place: Purim, Pesach, Lag BaOmer, and Shavuot. When the news of the pandemic initially broke, a large part of Slovak society viewed COVID-19 as a remote, and therefore, not entirely dangerous, threat. This attitude shifted on March 6, , when the first case of the disease was confirmed in the country. On March 9, the authorities reacted by introducing the first set of public health measures, which the Jewish Religious Community immediately …

Severe Acute Respiratory Syndrome Coronavirus 2 Transmission Potential, Iran, 2020, Kamalich Muniz-Rodriguez, Isaac Fung, Shayesteh R. Ferdosi, Sylvia Ofori, Yiseul Lee, Amna Tariq, Gerardo Chowell

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

To determine the transmission potential of severe acute respiratory syndrome coronavirus 2 in Iran in 2020, we estimated the reproduction number as 4.4 (95% CI 3.9–4.9) by using a generalized growth model and 3.5 (95% CI 1.3–8.1) by using epidemic doubling time. The reproduction number decreased to 1.55 after social distancing interventions were implemented.

Incarceration Experiences Of Older African American Adults Living With Hiv - A Constructivist Grounded Theory Study., Verena Schmidt

Electronic Theses and Dissertations

Two epidemics disproportionally impact older (50 years and over) African Americans compared to the general U.S. population: Incarceration and HIV/AIDS. Those aged 50 and older constitute the fastest growing age group of persons who are incarcerated in the United States. It is estimated that by the year 2030 about one third of the incarcerated population in the U.S. will be aged 55 years and older. While areas of “Incarceration, racial disparities and HIV” as well as “Aging and HIV” have been well studied and discussed in the literature, little is known about the lived incarceration experiences of African American persons …

Chimeric Ad5.F35 Vector Evades Anti-Adenovirus Serotype 5 Neutralization Opposing Gucy2c-Targeted Antitumor Immunity, John C. Flickinger, Jagmohan Singh, Robert D Carlson, Elinor Leong, Trevor R. Baybutt, Joshua Barton, Ellen M. Caparosa, Amanda M. Pattison, Jeff A. Rappaport, Jamin Roh, Tingting Zhan, Babar Bashir, Scott A Waldman, Adam E. Snook

Department of Pharmacology and Experimental Therapeutics Faculty Papers

BACKGROUND: Adenovirus serotype 5 (Ad5) is a commonly used viral vector for transient delivery of transgenes, primarily for vaccination against pathogen and tumor antigens. However, endemic infections with Ad5 produce virus-specific neutralizing antibodies (NAbs) that limit transgene delivery and constrain target-directed immunity following exposure to Ad5-based vaccines. Indeed, clinical trials have revealed the limitations that virus-specific NAbs impose on the efficacy of Ad5-based vaccines. In that context, the emerging focus on immunological approaches targeting cancer self-antigens or neoepitopes underscores the unmet therapeutic need for more efficacious vaccine vectors.

METHODS: Here, we evaluated the ability of a chimeric adenoviral vector (Ad5.F35) …

The Color Of Covid-19: Structural Racism And The Pandemic’S Disproportionate Impact On Older Racial And Ethnic Minorities, Marc A. Garcia, Patricia A. Homan, Catherine Garcia, Tyson H. Brown

Department of Sociology: Faculty Publications

Objectives: The aim of this evidence-based theoretically informed essay is to provide an overview of how and why the COVID-19 outbreak is particularly detrimental for the health of older Black and Latinx adults.

Methods: We draw upon current events, academic literature, and numerous data sources to illustrate how biopsychosocial factors place older adults at higher risk for COVID-19 relative to younger adults, and how structural racism magnifies these risks for older Black and Latinx adults.

Results: We identify three proximate mechanisms through which structural racism operates as a fundamental cause of racial/ethnic inequalities in COVID-19 burden among older adults: (1) …

Sodium Hypochlorite Reduces Postoperative Discomfort And Painful Early Failure After Carious Exposure And Direct Pulp Capping—Initial Findings Of A Randomized Controlled Trial, Nidambur Vasudev Ballal, Henry F. Duncan, Namith Rai, Prateek Jalan

Open Access archive

In this randomized controlled single-center clinical trial on 96 adult patients with parallel experimental groups (n = 48), the effects of washing a dentin/pulp wound in non-symptomatic teeth with extremely deep caries and pulpal exposure were compared between a 2.5% sodium hypochlorite (NaOCl) solution and a chemically-inert physiological saline control solution. After the allocated wound lavage, the pulps were capped with a mineral trioxide aggregate, covered by a glass-ionomer/resin liner, and the teeth were immediately restored with a resin-bonded-composite. In this first report, the early events were analyzed: postoperative discomfort (on an NRS-11 scale) at day-3 and-7 after intervention, and …

Monitoring Universal Health Coverage Reforms In Primary Health Care Facilities: Creating A Framework, Selecting And Fieldtesting Indicators In Kerala, India, Devaki Nambiar, D. Hari Sankar, Jyotsna Negi, Arun Nair

Open Access archive

In line with the Sustainable Development Goals (SDGs) and the target for achieving Universal Health Coverage (UHC), state level initiatives to promote health with "no-one left behind"are underway in India. In Kerala, reforms under the flagship Aardram mission include upgradation of Primary Health Centres (PHCs) to Family Health Centres (FHCs, similar to the national model of health and wellness centres (HWCs)), with the proactive provision of a package of primary care services for the population in an administrative area. We report on a component of Aardram's monitoring and evaluation framework for primary health care, where tracer input, output, and outcome …

Histone Demethylase Kdm5b As A Therapeutic Target For Cancer Therapy, Anmi Jose, Gautham G. Shenoy, Gabriel Sunil Rodrigues, Naveena A.N. Kumar

Open Access archive

Lysine-specific demethylase 5B (KDM5B/PLU1/JARID1B) is found to be overexpressed in numerous malignancies, including breast, lung, skin, liver, and prostate cancer. Identification of molecules targeting the KDM5B enzyme could be a potential lead in cancer research. Although many KDM5B inhibitors with promising outcomes have been developed so far, its further application in clinical practice is limited due to toxicity and lack of target specificity. Here, we summarize the significance of targeting KDM5B in anticancer therapy and report the molecular docking studies of some known anti-viral agents, decitabine, entecavir, abacavir, penciclovir, and 3-deazaneplanocin A in the catalytic domain JmjC of KDM5B. These …

Molecular Assessment Of Epiretinal Membrane: Activated Microglia, Oxidative Stress And Inflammation, Sushma Vishwakarma, Rishikesh Kumar Gupta, Saumya Jakati, Mudit Tyagi

Open Access archive

Fibrocellular membrane or epiretinal membrane (ERM) forms on the surface of the inner limiting membrane (ILM) in the inner retina and alters the structure and function of the retina. ERM formation is frequently observed in ocular inflammatory conditions, such as proliferative diabetic retinopathy (PDR) and retinal detachment (RD). Although peeling of the ERM is used as a surgical intervention, it can inadvertently distort the retina. Our goal is to design alternative strategies to tackle ERMs. As a first step, we sought to determine the composition of the ERMs by identifying the constituent cell-types and gene expression signature in patient samples. …

Impact Of The Societal Response To Covid-19 On Access To Healthcare For Non-Covid-19 Health Issues In Slum Communities Of Bangladesh, Kenya, Nigeria And Pakistan: Results Of Pre-Covid And Covid-19 Lockdown Stakeholder Engagements, Syed A K Shifat Ahmed, Motunrayo Ajisola, Kehkashan Azeem, Pauline Bakibinga, Yen-Fu Chen, Narjis Rizvi, Syed Iqbal Azam, Romaina Iqbal, Ahsana Nazish, Komal Tabani

Community Health Sciences

Introduction: With COVID-19, there is urgency for policymakers to understand and respond to the health needs of slum communities. Lockdowns for pandemic control have health, social and economic consequences. We consider access to healthcare before and during COVID-19 with those working and living in slum communities.
Methods: In seven slums in Bangladesh, Kenya, Nigeria and Pakistan, we explored stakeholder perspectives and experiences of healthcare access for non-COVID-19 conditions in two periods: pre-COVID-19 and during COVID-19 lockdowns.
Results: Between March 2018 and May 2020, we engaged with 860 community leaders, residents, health workers and local authority representatives. Perceived common illnesses in …

Prevalence Of Risk Factors Of Acute Kidney Injury In A Tertiary Care Hospital In Pakistan, Ainan Arshad, Ahmed Ayaz

Section of Internal Medicine

The objective of this study was to determine the prevalence of preventable risk factors of acute kidney injury in a tertiary care hospital in Pakistan. All patients admitted at Aga Khan University Hospital, Karachi with diagnosis of acute kidney injury were included out of which 134 were selected via random sampling. Patients with existing CKD were excluded. Data was then collected retrospectively from medical records of these patients. Mean age was 60±11.7 years while mean serum creatinine on admission was 2.4±1.3 (mg/dl). Sepsis played a role in almost half of the patients [60 (45%)]. Other factors included diarrhoea [23 (17%)], …

Evaluation Of The Humoral Immune Response As A Potential Indicator Of Disease Severity For Patients Hospitalized With Covid-19, Spencer Sterling

Capstone Experience: Master of Public Health

Members of the family Coronaviridae, including the severe acute respiratory syndrome coronaviruses (SARS-CoV-1 and SARS-CoV-2), Middle East respiratory syndrome coronavirus (MERS-CoV) and seasonal human coronaviruses (HCoV-HKU1and HCoV-OC43), are highly communicable respiratory viruses; SARS-CoV-1, SARS-CoV-2, and MERS can cause severe disease, while seasonal human coronaviruses present with mild to moderate illness. Coronavirus envelope spike (S) glycoproteins are involved in receptor binding and cell fusion, and are the primary target for a neutralizing humoral response. The S protein is comprised of the S₁ and S₂ subunits; the S₁ subunit contains the receptor-binding domain (RBD), while the S_{2 …}