Digital Commons Network^™

Assisted Reproductive Technologies In Male Ambystoma Tigrinum With Application To Threatened Newt Species, Amanda Gillis

Theses and Dissertations

The world is currently facing an amphibian extinction crisis and wild salamanders and newts (Order: Caudata) are the most disadvantaged with 52% of species threatened. Captive breeding programs are been established to act as assurance colonies, but they are overwhelmingly failing due to the lack of environmental cues to stimulate reproduction and other factors. Therefore, assisted reproductive technologies (ART) are being developed to overcome these barriers. This project expands upon the limited existing information on caudate ART through studies in the model species, Ambystoma tigrinum, for application to threatened species. Specific objectives included the characterization of motility longevity in artificially …

Intimate Partner Violence Screening Among Barbadian Primary Care Professionals: An Exploratory Study Of Practitioner Attitudes, Beliefs, Knowledge And Screening Intention, Janelle Bryan

Doctoral Dissertations

Intimate Partner Violence (IPV), the most prevalent type of violence against women, has been recognized as a human rights violation by intergovernmental organizations and international law. Due to its physical and psychological sequelae, the World Health Organization has considered IPV a major global public health issue since 1997. Primary care health care professionals (HCPs) are considered especially well-positioned to identify women experiencing IPV, yet screening rates are low. Utilizing the Integrated Behavioral Model (IBM) and Intersectional Feminism as guiding theoretical frames, this mixed method study (qualitative, N = 35; quantitative, N = 176) explored Barbadian HCPs’ attitudes, beliefs and knowledge …

Bk Virus Nephropathy: Prevalence, Impact And Management Strategies, Rajeev Sharma, Mareena Zachariah

School of Medicine Faculty Research

BK virus reactivation as a result of therapeutic immunosuppression following renal transplant can result in BK polyomavirus nephropathy and renal allograft loss. This is a complex and challenging clinical problem with a range of management options and practices reported in literature. The current standard for early diagnosis and treatment is surveillance by measuring viral DNA in blood using qPCR. Immunosuppression reduction is the cornerstone of effective management but is associated with a risk of acute rejection following treatment.

The Mother-Infant Dyad: Reconstructing Maternal Nutritional Status At Put Dragulina Cemetery, Julianne Marie Paige

Theses and Dissertations

This research investigates maternal nutritional status through the analysis of young infants (N=27) that are likely pre-weaned from two Roman occupational periods at Put Dragulina. Because young infants are solely dependent on the nutritional status of their mother while in utero and postpartum through the consumption of breast milk, the presence of skeletal pathologies positively associated to nutritional deficiencies on the remains of young infants can be analyzed to reconstruct the nutritional status of the infant’s mother. This study finds that 89% (N=24) of young infants, regardless of occupational period, presented with skeletal pathologies consistent with nutritional deficiencies. These results …

The Prevalence And Mode Of Persistence Of Salmonella On Commercial Poultry Processing Equipment After Sanitization Procedures, Tomilola Olofunke Obe

Theses and Dissertations

The prevalence and mode of persistence of Salmonella on commercial poultry processing equipment was examined in this study. The equipment surfaces of six commercial processing plants were sampled over three-time periods designated as A (after processing), B (after cleaning), and C (after sanitization) and each plant was visited three times. Salmonella prevalence was greater (p<0.0001) at time A than times B and C, while there were no differences (p=0.386) between times B and C. A total of twentyive Salmonella isolates from five distinct serovars were recovered from the processing plants. Further examination of the recovered isolates showed that tolerance to sanitizing agents (chlorine and quaternary ammonium compounds, QAC) and/or biofilm formation was the possible mode of persistence. In addition, all the isolates were resistant to multiple antibiotics in different classes of drugs and more than two genes that are responsible for ⅰ). biofilm formation, ⅱ). resistance to QAC, ⅲ). oxidative stress response, and ⅳ). resistance to antibiotics were detected. Three selected isolates were further characterized based on virulence factors and antimicrobial resistance using whole genome sequencing (WGS) to possibly predict phenotypic characteristics. The WGS data correlates with phenotypic characteristics that were previously observed in the isolates including the ability to produce biofilms and resistance to antibiotics including β-lactams, aminoglycosides, and cephalosporins. WGS predicted the isolates carried resistance genes for antibiotic drug classes that were not observed phenotypically. These include macrolides and fluoroquinolone, which is a concern due to its use in treating foodborne infection. Furthermore, the genome of the three selected isolates were predicted to have over sixty virulence genes that allow Salmonella to invade, attach, and colonize the host cells. The results from this study suggest that the antimicrobials used for sanitization may be insufficient to inactivate Salmonella because of the ability to produce biofilms on processing surfaces. Most importantly, the results suggest the ability of the isolates to cause infection in humans meaning if contamination were to occur, the right antibiotic treatment could be a challenge. Further research is imperative to determine the effective antimicrobial for Salmonella biofilms.

Biomolecular Analysis Of An Insect Of Economic Importance, The Multicolored Asian Lady Beetle, Selene Perales Sanchez

Theses and Dissertations

Insect-human interactions are very complex; one example is the relationship between humans and the multicolored Asian lady beetle (ALB; Harmonia axyridis). ALB, a native to Asia, was introduced into North American agricultural fields and orchards as a biological control agent for aphids and other soft-bodied insects. However, it is considered a pest by some humans as it invades houses in the fall and winter months. Additionally, ALBs feed on fruits when aphids are scarce, and the hemolymph secreted by ALBs contaminates fruit and affects the taste of fruit products. ALBs invasive behavior has led to concern that this non-native species …

Intraspecific Variability Of Edwardsiella Piscicida And Cross-Protective Efficacy Of A Live-Attenuated Edwardsiella Ictaluri Vaccine In Channel And Channel × Blue Hybrid Catfi, Adrian Lopez Porras

Theses and Dissertations

Incidence and prevalence of Edwardsiella piscicida has increased in Mississippi farm-raised catfish in recent years. Edwardsiella piscicida affects mostly market-sized catfish during the final stages of the production cycle resulting in significant economic losses. The objectives of this study were to determine the genetic variability of E. piscicida, assess virulence in channel and hybrid catfish, and evaluate the capacity of a live-attenuated E. ictaluri vaccine to protect channel and hybrid catfish against heterologous E. piscicida isolates. This work identified five discrete E. piscicida lineages, along with group specific associations of several virulence related genes. In general, E. piscicida was shown …

Exploring The Vaginal Microbiome In Relation To Pregnancy Status And Reproductive Performance In Brangus Heifers, Riley Messman

Theses and Dissertations

Most research evaluating the effects of the reproductive tract microbiota on reproductive performance has been done in humans, thus far. In bovids, reproductive microbiota research is not as advanced, with preliminary conclusions, not supported by contamination checks or repeatability. Our studies concluded that endogenous reproductive hormones, days of gestation, and pregnancy status does not change the overall vaginal microbiota composition. Although, the overall composition did not change there were species level differences. These differences could have implications in reproductive performance and fertility in heifers. Heifers that undergo nutrient restriction have similar vaginal microbiota to adequately fed heifers with no species …

Adult Liver Transplantation: A Uk Clinical Guideline - Part 1: Pre-Operation, Charles Millson, Aisling Considine, Matthew E. Cramp, Andrew Holt, Stefan Hubscher, John Hutchinson, Kate Jones, Joanna Leithead, Steven Masson, Krish Menon, Darius Mirza, James Neuberger, Raj Prasad, Anthony Pratt, Wendy Prentice, Liz Shepherd, Ken Simpson, Doug Thorburn, Rachel Westbrook, Dhiraj Tripathi

Peninsula Medical School

Liver transplantation is a highly successful treatment for all types of liver failure, some non-liver failure indications and liver cancer. Most referrals come from secondary care. This first part of a two-part guideline outlines who to refer, and how that referral should be made, including patient details and additional issues such as those relevant to alcohol and drug misuse. The process of liver transplant assessment involves the confirmation of the diagnosis and non-reversibility, an evaluation of comorbidities and exclusion of contraindications. Finally, those making it onto the waiting list require monitoring and optimising. Underpinning this process is a need for …

Tonic Tcr Signaling Inversely Regulates The Basal Metabolism Of Cd4+ T Cells, Ashley A Viehmann Milam, Juliet M Bartleson, Michael D Buck, Chih-Hao Chang, Alexey Sergushichev, David L Donermeyer, Wing Y Lam, Erika L Pearce, Maxim N Artyomov, Paul M Allen

2020-Current year OA Pubs

The contribution of self-peptide-MHC signaling in CD4

An Examination Of Certified Nurse-Midwives' Attitudes And Beliefs Surrounding Breastsleeping: Implications For Advanced Nursing Practice And Education, Lucy Mueller Wiesemann

Grace Peterson Nursing Research Colloquium

An Examination of Certified Nurse-Midwives' Attitudes and Beliefs Surrounding Breastsleeping: Implications for Advanced Nursing Practice and Education

Lucy Mueller Wiesemann, DNP, CNM, APN, CLS; DePaul University, Chicago, IL

Abstract

Introduction: Breastsleeping, defined as cosleeping while breastfeeding, is a practice commonly employed in breastfeeding families. However, literature examining this concept, its prevalence, and related education for safe breastsleeping is scant. Provider’s attitudes surrounding breastsleeping play an essential role in practice and outcomes when caring for breastfeeding patients and families. The purpose of the study was to examine Certified Nurse-Midwives’ attitudes and beliefs surrounding breastsleeping.

Methods: An adapted 18-item Nurse Attitudes and …

August 6, 2020: Covid-19 Campus Update, Kettering University

Communication Updates

The COVID-19 Response Team continues to work with Genesee County Public Health Department and with the Office of the President to adapt to the situation as it evolves and to provide our community with the most current information regarding the COVID-19 pandemic. The University is fully committed to the health and safety of its entire community, and will continue to closely monitor this situation and any others that impact our campus.

Knowlesi Malaria, Yee Ling Lau

Archival Material (2020s)

Originally a simian malaria, Plasmodium knowlesi is now known as the fifth human malaria species. Since the report of a large focus of human knowlesi cases in Sarawak in 2004, many more human cases have been reported in all of the countries in Southeast Asia and in travellers returning from these countries. The zoonotic nature of this infection hinders malaria elimination efforts. In order to grasp the current perspective of knowlesi malaria, this inaugural lecture explores the different aspects of the disease including risk factors, diagnosis, treatment, molecular and functional studies. Current studies do not provide sufficient data for an …

The Investigation Of Surface Structures On Various Pathogens And Their Interactions With The Human Immune System, Carmen M. Villalobos

Biomedical Engineering ETDs

The cell surface is the first interface the host immune system encounters and

its investigation has led to a better understanding of cellular biology and types of

pathways that pathogens target in a host cell. The cell surface has evolved to include

many functions such as manipulation of the cytoskeleton, cell signaling, membrane

trafficking, adhesion, and integration into host tissue. The pathogens of interest are

the pathogenic fungus, Candida albicans, and the parasite, Giardia lamblia and we

investigate the consequences of drug treatments on the cell surface, leading to

promising new targets.

Uab Launches Second Round Of Urgent, High-Impact Covid-19 Research, Jeff Hansen

Browse All News

No abstract provided.

Sars-Cov-2: Virology And Drug Repurposing Approaches, Ratika Rahmasari, Heri Setiawan, Rezi Riadhi Syahdi, Ayun Arifianti, Marina Ika Irianti, Rani Sauriasari, Juliann Nzembi Makau, Muhareva Raekiansyah

Pharmaceutical Sciences and Research

An emerging coronavirus, SARS-CoV-2, is the causative agent for the ongoing pandemic of coronavirus disease 2019 (COVID-19), which has caused a worldwide social and economic disruption. Currently, no antiviral drugs with proven clinical efficacy, or vaccines for its prevention. Therefore, to combat the pandemic of this novel coronavirus, new effective treatments are urgently needed. In the process of traditional drug development, developing new drugs from scratch is a time- consuming process, requires high-investment, and is a high-risk process, which is impractical to face the immediate global challenge of the SARS-CoV-2 pandemic. Drug repurposing strategy is one of the effective ways …

Dermaseptin-Based Antiviral Peptides To Prevent Covid-19 Through In Silico Molecular Docking Studies Against Sars-Cov-2 Spike Protein, Taufik Muhammad Fakih

Pharmaceutical Sciences and Research

A pandemic coronavirus disease of 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now been declared a global pandemic by the World Health Organization. The search for new drugs, especially by utilizing antiviral peptides is a very potential area. Through this study, protein-peptide docking and protein-protein docking simulations were conducted using in silico methods to identify, evaluate, and explore the molecular affinity and interaction of dermaseptin peptide molecules produced by frogs of the genus Phyllomedusa against the SARS-CoV-2 spike protein macromolecule, and its effect on attachment to the surface of the ACE-2 (Angiotensin Converting Enzyme-2) receptor. …

Chloroquine: An Old To Be Repurposed Drug For Covid-19 Infection (Risk And Benefit), Oki Nugraha Putra, Ana Khusnul Faizah, Nani Wijayanti Dyah Nurrahman, Hardiyono Hardiyono

Pharmaceutical Sciences and Research

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 2019 (COVID-19) with a high rate of mortality. Chloroquine and hydroxychloroquine have been used for antimalarial and autoimmune diseases for many years. Due to low toxicity and well tolerability as well as immunomodulatory properties, these drugs are proposed to treat viral infection. Some studies, both in vitro and in a clinical setting, have been evaluated for their ability to treat SARS- CoV-2 as promising therapies. Although The National Agency of Drugs and Food Control of The Republic of Indonesia issued emergency authorization for chloroquine and hydroxychloroquine to be used against …

Remdesivir: Mechanism And Effectiveness For Coronavirus Disease 2019 (Covid-19), Vina Neldi, Suharjono Suharjono

Pharmaceutical Sciences and Research

Currently, coronavirus disease 2019 (COVID-19) is a very serious health problem. The World Health Organization (WHO) has characterized this disease as a pandemic. Recommendations related to vaccines and drugs are not available yet because they are still in the clinical trial phase, and one of the superior drugs is remdesivir which has an antiviral activity. Several clinical trials of this drug are being carried out with the aim of evaluating its safety and efficacy in COVID-19 patients. There are two clinical trials with completed recruitment status, which are NCT04257656 and NCT04280705. NCT04257656 showed that remdesivir had faster time for clinical …

Covariates And Spatial Interpolation Of Hiv Screening In Mozambique: Insight From The 2015 Aids Indicator Survey, Pascal Agbadi, Jerry John Nutor, Ernest Darkwah, Henry Ofori Duah, Precious Adade Duodu, Robert Kaba Alhassan, Kimberly Baltzell

College of Nursing Faculty Research and Publications

We examined the factors associated with human immunodeficiency virus (HIV) screening and developed a HIV screening prevalence surface map using spatial interpolation techniques to identify the geographical areas with the highest and lowest rates of HIV screening in Mozambique. We analyzed the cross-sectional 2015 Mozambique AIDS Indicator Surveys with an analytic sample of 12,995 participants. Analyses were conducted on SPSS-21, STATA-14, and R freeware 3.5.3. We adjusted for the sample design and population weights. Results indicated that 52.5% of Mozambicans had undergone HIV screening. Mozambicans with these characteristics have a higher probability of undergoing HIV screening: females, those with a …

Cards From The Community: Engagement Of The Local Community To Enhance Patient And Staff Experience During The Covid-19 Pandemic, Brittany Branson

Patient Experience Journal

During the COVID-19 pandemic, in accordance with recommendations from the Centers for Disease Control and Prevention (CDC.gov), strict visitation restrictions were implemented across the six hospital Yale New Haven Health System (YNHHS) in an effort to protect patients, visitors and staff. In addition, to the extent that it is possible, YNHHS staff have been encouraged to work remotely. While these measures achieve the goal of reducing the number of people within the hospitals and enable successful social distancing, they also may contribute to social isolation for both patients and staff. A program called “Cards from the Community” was developed to …

Flattening The Curve Of Distress: A Public-Facing Webinar For Psychoeducation During Covid-19, Grant Smith, Stephanie Harman, Keri Brenner

Patient Experience Journal

This case report describes the development, implementation and evaluation of a public-facing webinar that provided psychoeducation addressing the emotional distress that has accompanied the coronavirus pandemic. Using a webinar was an effective strategy for reaching a large, public audience and making content from expert clinicians accessible. Participants were likely to recommend the webinar to friends or family. Participants appreciated that the webinar acknowledged the presence of distressing emotions and provided practical advice for reducing the negative psychological sequelae of the coronavirus pandemic. Areas for improvement included addressing technical issues and incorporating additional information into the webinar.

Experience Framework

This article …

The Rapid Increase In Telemedicine Visits During Covid-19, Chelsea Johnson, Kathryn Taff, Brian R. Lee, Amanda Montalbano

Patient Experience Journal

Prior to the COVID-19 pandemic, facilitated telemedicine encounters were available at outreach locations; however, our tertiary children’s hospital had not invested widely in direct to patient telemedicine. Our daily pediatric subspecialty visits dropped from an average of 2066 visits a day prior to COVID-19 in our community to 1000 patients a day during the study period. Over the four-week period from April 15 to May 12, 2020, patient and family experience ratings of percentage of positive responses (9 or 10) on the provider rating 0-10 scale between telemedicine and in-person visits were compared for our pediatric subspecialty clinics using a …

A Covid-19 Patient’S Experience: Engagement In Disease Management, Interactions With Care Teams And Implications On Health Policies And Managerial Practices, Lihua Dishman, Vicki Schroeder

Patient Experience Journal

This narrative inquiry aimed to explore a COVID-19 patient’s lived experience from contracting the disease to recovery and understand the implications of this unique patient experience on health policies and managerial practices. The personal narrative approach was used to chronicle the patient’s weekly journey in disease management. Best practices emerged from her and her family members’ engagement in managing COVID-19, and interactions with her primary care provider and COVID-19 Response Team. Her COVID-19 patient experience also provided a basis for implications on public health and healthcare policies and managerial practices. Three key dimensions were perceived to have positively impacted the …

Is This Really Happening? Family-Centered Care During Covid-19: People Before Policy, Terri Savino, Karri Crispino

Patient Experience Journal

In the middle of a global pandemic, hospitals created policies for visitor restrictions to reduce the transmission of coronavirus to protect patients and staff and developed protocols allowing only one support person to call the critical care unit for patient updates. Late on a Tuesday afternoon, the Manager of Patient Experience received a phone call asking her to call Karri, the wife of one of our patients who was on a ventilator. Karri was struggling with updating her mother-in-law because she was very upset with the news she received, making it difficult to call her husband’s mom. Karri asked the …

2020-08-04_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Health Implications Of Incarceration And Reentry On Returning Citizens: A Qualitative Examination Of Black Men’S Experiences In A Northeastern City, Jason M. Williams, Sean K. Wilson, Carrie Bergeson

Department of Justice Studies Faculty Scholarship and Creative Works

While a great deal of research captures the lived experiences of Black men as they navigate through the criminal legal system and onto reentry, very little research is grounded in how those processes are directly connected to their health. Although some research argues that mass incarceration is a determinant of poor health, there is a lack of qualitative analyses from the perspective of Black men. Black men face distinct pathways that lead them into the criminal legal system, and these same pathways await them upon reentry. This study aims to examine the health implications associated with incarceration and reentry of …

Social Media And Utilization Of Information On Contagious Diseases: The Case Of Medical Students Of Abia State University Teaching Hospital Aba, Scholastica A.J. Chukwu Rev Sr Dr., Augonus Nnamdi Uhegbu Prof.

Library Philosophy and Practice (e-journal)

This research examines social media and utilization of information on contagious diseases by medical students of Abia State University Teaching Hospital Aba. The research adopts survey design to investigate a sample of 321 medical students of ABSU Teaching Hospital who were registered undergraduates in the 2017/2018 academic session. Because the number of the students was adequate and manageable, the research adopted the census sampling technique. Structured and validated questionnaire with a reliability coefficient value of 0.81 was used to gather data for the study. Results reveal that the medical students received and made use of information on contagious diseases from …

August 3, 2020: Covid-19 Campus Update, Kettering University

Communication Updates

The COVID-19 Response Team continues to work with Genesee County Public Health Department and with the Office of the President to adapt to the situation as it evolves and to provide our community with the most current information regarding the COVID-19 pandemic. The University is fully committed to the health and safety of its entire community, and will continue to closely monitor this situation and any others that impact our campus

Ada News - 08/03/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.