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Current Prospects And Outlook Of Crispr/Cas Technology In Clinical Therapy, James Piper

Theses and Graduate Projects

Gene editing capabilities have expanded enormously since researchers first demonstrated the robust, accurate, and efficient endonuclease activity of the CRISPR/Cas riboprotein enzyme. Since this gene editing technique was first described in 2013, the prospect of gene therapy as a viable clinical tool has improved immensely. CRISPR/Cas techniques and the methods by which they are delivered into cells, have evolved rapidly since the technology􏰿s inception, and successful, intentional genetic alterations of numerous mammalian cell lines have been reported. As a research tool, CRISPR/Cas9 has already proven itself indispensable in a brief period of time. While there are not numerous clinical trials …

Project Aims To Address Hiv And Substance Use In Jefferson County Youth, Matt Windsor

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No abstract provided.

Uab Covid Respiratory Clinic Expands Telehealth Efforts, Staff

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No abstract provided.

Characterizing The Epigenetic And Transcriptomic Responses To Perkinsus Marinus Infection In The Eastern Oyster Crassostrea Virginica, Kevin M. Johnson, K. A. Sirovy, Sandra M. Casas, Jerome F. La Peyre, Morgan W. Kelly

Faculty Publications

© Copyright © 2020 Johnson, Sirovy, Casas, La Peyre and Kelly. Eastern oysters in the northern Gulf of Mexico are routinely infected with the protistan parasite Perkinsus marinus, the cause of the disease commonly known as dermo. Recent experimental challenges among Atlantic coast populations have identified both resistant and susceptible genotypes using comparative transcriptomics. While controlled experimental challenges are essential first assessments, expanding this analysis to field reared individuals provides an opportunity to identify key genomic signatures of infection that appear both in the laboratory and in the field. In this study we combined reduced representation bisulfite sequencing with 3′ …

Characterizing The Epigenetic And Transcriptomic Responses To Perkinsus Marinus Infection In The Eastern Oyster Crassostrea Virginica, Kevin M. Johnson, K. A. Sirovy, Sandra M. Casas, Jerome F. La Peyre, Morgan W. Kelly

Faculty Publications

© Copyright © 2020 Johnson, Sirovy, Casas, La Peyre and Kelly. Eastern oysters in the northern Gulf of Mexico are routinely infected with the protistan parasite Perkinsus marinus, the cause of the disease commonly known as dermo. Recent experimental challenges among Atlantic coast populations have identified both resistant and susceptible genotypes using comparative transcriptomics. While controlled experimental challenges are essential first assessments, expanding this analysis to field reared individuals provides an opportunity to identify key genomic signatures of infection that appear both in the laboratory and in the field. In this study we combined reduced representation bisulfite sequencing with 3′ …

Challenges And Opportunities In Conducting And Applying Design Research Beyond Global North To The Global South, Emmanuel Tsekleves, Andy Darby, Collins Ahorlu, Roger Pickup, Dziedzom De Souza, Daniel Boakye

DRS Biennial Conference Series

With an increase in international projects, comes increased opportunities for design researchers to contribute to research that tackles Sustainable Development Goals in the Global South. Nevertheless, the role of design within this context is disparate and detached, with very limited design literature on the subject. As such, this paper has identified the key challenges and barriers that design researchers face in conducting and applying design research in a Global South Context. Based on a workshop with design research experts doing research in Global South, the literature and lessons learnt from running a design-led project in Ghana, we are presenting and …

Protocol For A National Probability Survey Using Home Specimen Collection Methods To Assess Prevalence And Incidence Of Sars-Cov-2 Infection And Antibody Response, Aaron J. Siegler, Patrick S. Sullivan, Travis Sanchez, Ben Lopman, Mansour Fahimi, Charles Sailey, Martin Frankel, Richard Rothenberg, Colleen F. Kelley, Heather Bradley

Publications and Research

Purpose: The U.S. response to the SARS-CoV-2 epidemic has been hampered by early and ongoing delays in testing for infection; without data on where infections were occurring and the magnitude of the epidemic, early public health responses were not data-driven. Understanding the prevalence of SARSCoV- 2 infections and immune response is critical to developing and implementing effective public health responses. Most serological surveys have been limited to localities that opted to conduct them and/or were based on convenience samples. Moreover, results of antibody testing might be subject to high false positive rates in the setting of low prevalence of immune …

Pandemic Planning, Dwight Merriam

Journal of Comparative Urban Law and Policy

No abstract provided.

2020-08-10_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Fatal Case Of Newborn Lassa Fever Virus Infection Mimicking Late Onset Neonatal Sepsis: A Case Report From Northern Nigeria, Taofik Oluwaseun Ogunkunle, Surajudeen Oyeleke Bello, Chinwe Immaculata Anderson, Rashida Musa, Rasaq Olaosebikan, Abdulazeez Imam

Department of Pharmacology and Experimental Therapeutics Faculty Papers

BACKGROUND: Lassa fever is a zoonotic viral infection endemic to the West Africa countries. It is highly fatal during pregnancy and as such reports of neonatal onset Lassa fever infections are rare in scientific literature. We report a fatal case of Lassa fever in a 26-day-old neonate mimicking the diagnosis of late-onset neonatal sepsis.

CASE PRESENTATION: The patient is a 26-day-old neonate who was admitted with a day history of fever, poor feeding, pre-auricular lymphadenopathy and sudden parental death. He was initially evaluated for late onset neonatal sepsis. He later developed abnormal bleeding and multiple convulsions while on admission, prompting …

'We Intend To Keep Our Uab Community Very Safe': Answers From Aug. 7 Faculty Town Hall, Matt Windsor

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No abstract provided.

Intravenous Catheter Antiseptics To Prevent Infections, Tiara Ford

MSN Capstone Projects

This presentation focuses on finding the most effective antiseptic to preventing intravenous catheter related infections (CRI). There have been many antiseptics used over the years for cleaning the site before insertion, during maintenance, and removal. But there still have been cases of CRI that are costly to hospitals, outpatient settings, and patients. In this benchmark study there have been 12 research articles that have been intensely reviewed to come up with own conclusion, the best antiseptic. Chlorhexidine has been found to be the most effective according to the 12 research articles compared with other antiseptics. The presentation is comparing chlorhexidine …

Universal Masking In The United States: The Role Of Mandates, Health Education, And The Cdc, Lawrence O. Gostin, I. Glenn Cohen, Jeffrey P. Koplan

Georgetown Law Faculty Publications and Other Works

The Centers for Disease Control and Prevention (CDC) recommends cloth face coverings in public settings to prevent spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). Face coverings decrease the amount of infectious virus exhaled into the environment, reducing the risk an exposed person will become infected.1 Although many states and localities have ordered mask use, considerable variability and inconsistencies exist. Would a national mandate be an effective COVID-19 prevention strategy, and would it be lawful? Given the patchwork of state pandemic responses, should the CDC have enhanced funding and powers to …

The San Luis Valley And Migrant Health, Julianne Armijo

Theoretical Foundation in Advanced Practice Nursing

No abstract provided.

2020-08-09_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Social Support For Pregnant Women And New Mothers During The Covid-19 Pandemic, Kalissa A. Morgan

Theoretical Foundation in Advanced Practice Nursing

No abstract provided.

Covid-19 Pandemic Disease: A Bibliometric Study, Dr. Jayaprakash G. Hugar, Dr.M.M.Bachalapur, Dr.Prasanna Kumara

Library Philosophy and Practice (e-journal)

Background: Novel coronavirus disease (COVID-19) was initially detected in China a short time ago, and ultimately developed a most important global health nervousness due to its nature and extensive spreading everywhere in this world. Despite a rising awareness in COVID-19 among the people, little is understood about the present state of data on COVID-19, which may describe what proportion is understood about this difficulty. This bibliometric analysis assessed the present-day scientific information to measure the growth of literature available on COVID-19, recognise the leading research stakeholders, and explore the same.

Methods: Bibliometric records on Coronavirus Disease – 19 reported studies …

Achieving Sustainable Development Goals Two And Three: Role Of Academic Libraries, Francisca Chinyeaka Mbagwu, Martha Lyaka, Jackline E. Kiwelu, Lydia Nyantakyi-Baah, Marlene Holmner

Library Philosophy and Practice (e-journal)

Abstract

Purpose: This study investigated the role academic libraries play in the achievement of sustainable development goals 2 and 3.

Design/Methodology/Approach: An exploratory approach through an extensive review of related literature and case study was adopted for this study. Discussion on the efforts made by academic libraries in Federal University of Technology Library Owerri, Nigeria; Makerere University Library, Uganda, Kampala International University, Uganda and Ghana Institute of Journalism Library made in the achievement of SDGs 2 and 3. The study was guided by three research questions. Research questions 1 and 2 were gotten from the literature reviewed while the answer …

A Scientometric Analysis Of Literature Growth In Anthrax, Santha Subbulaxmi S, Viswanathan Vaidhyanathan, Govindarajan R

Library Philosophy and Practice (e-journal)

Anthrax is an infectious disease which occurs regularly in southern Europe. It is also used as a weapon by a number of countries. This study is an attempt to investigate and analyze about the literature output on Anthrax. The aim of the present study was to identify literature growth over the period, literature distribution and authorship pattern. The data was obtained from PubMed using the keywords "Anthrax”. It was found that a total of 1,955 published literatures for the period 2011-2018 in the field of Anthrax were contributed by 8,185 unique authors in 11 languages in 694 journals in 12 …

2020-08-08_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Previous And Active Tuberculosis Increases Risk Of Death And Prolongs Recovery In Patients With Covid-19, Karla Therese L. Sy, Nel Jason L. Haw, Jhanna Uy

Health Sciences Faculty Publications

Background: There is a growing literature on the association of SARS-CoV-2 and other chronic conditions, such as noncommunicable diseases. However, little is known about the impact of coinfection with tuberculosis. We aimed to compare the risk of death and recovery, as well as time-to-death and time-to-recovery, in COVID-19 patients with and without tuberculosis.

Methods: We created a 4:1 propensity score matched sample of COVID-19 patients without and with tuberculosis, using COVID-19 surveillance data in the Philippines. We conducted a longitudinal cohort analysis of matched COVID-19 patients as of May 17, 2020, following them until June 15, 2020. The …

Tlr Antagonism By Sparstolonin B Alters Microbial Signature And Modulates Gastrointestinal And Neuronal Inflammation In Gulf War Illness Preclinical Model, Dipro Bose, Ayan Mondal, Punnag Saha, Diana Kimono, Sutapa Sarkar, Ratanesh K. Seth, Patricia Janulewicz, Kimberly Sullivan, Ronnie Horner, Nancy Klimas, Mitzi Nagarkatti, Prakash Nagarkatti, Saurabh Chatterjee

Faculty Publications

The 1991 Persian Gulf War veterans presented a myriad of symptoms that ranged from chronic pain, fatigue, gastrointestinal disturbances, and cognitive deficits. Currently, no therapeutic regimen exists to treat the plethora of chronic symptoms though newer pharmacological targets such as microbiome have been identified recently. Toll-like receptor 4 (TLR4) antagonism in systemic inflammatory diseases have been tried before with limited success, but strategies with broad-spectrum TLR4 antagonists and their ability to modulate the host-microbiome have been elusive. Using a mouse model of Gulf War Illness, we show that a nutraceutical, derived from a Chinese herb Sparstolonin B (SsnB) presented a …

Summer Commencement Program, August 7 2020 (Virtual), Coastal Carolina University

Commencement Programs

Program of Commencement Exercises at Coastal Carolina University.

August 7, 2020: Covid-19 Campus Update, Kettering University

Communication Updates

No abstract provided.

2020-08-07_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Mediastinal Lymphadenopathy, Class-Switched Auto-Antibodies And Myocardial Immune-Complexes During Heart Failure In Rodents And Humans., Amalia Sintou, Catherine Mansfield, Alma Iacob, Rasheda A Chowdhury, Salomon Narodden, Stephen M Rothery, Robert Podovei, Jose L Sanchez-Alonso, Elisa Ferraro, Pamela Swiatlowska, Sian E Harding, Sanjay Prasad, Nadia Rosenthal, Julia Gorelik, Susanne Sattler

Faculty Research 2020

Mediastinal lymphadenopathy and auto-antibodies are clinical phenomena during ischemic heart failure pointing to an autoimmune response against the heart. T and B cells have been convincingly demonstrated to be activated after myocardial infarction, a prerequisite for the generation of mature auto-antibodies. Yet, little is known about the immunoglobulin isotype repertoire thus pathological potential of anti-heart auto-antibodies during heart failure. We obtained human myocardial tissue from ischemic heart failure patients and induced experimental MI in rats. We found that anti-heart autoimmunity persists during heart failure. Rat mediastinal lymph nodes are enlarged and contain active secondary follicles with mature isotype-switched IgG2a B …

Con Confianza: Using Community-Based Participatory Research Principles To Inform Community-Academic Partnership Practices And Build Trust In Hispanic Communities, Sharon Tafolla

Master's Projects and Capstones

Hispanic communities are at disproportionate risk for chronic diseases and researchers have cited the need for further community and culturally informed studies to improve research outcomes to either make treatments and interventions more generalizable or modify them to the needs of Hispanic communities. However, many of the same linguistic and cultural barriers to health care access and utilization also impact the ability for Hispanic groups to participate in research studies. Community Academic Partnerships (CAPs) are positioned to conduct culturally and linguistically competent research in Hispanic communities. For research in Hispanic communities to be effective, CAPs must prioritize practices that build …

When Two Health Emergencies Collide: Planning For The Crisis Health Needs Of Opioid Abusers And The Psychological Consequences Of Covid-19, Amanda Rehn

Master's Projects and Capstones

The COVID-19 pandemic has created new barriers for people suffering from mental illness and substance use disorders. From its expected major impact on mental health, social distance measures imposed worldwide are themselves risk factors for increased mental health problems, including opioid abuse. Since drug treatment for opioid use disorders is highly regulated by health authorities, people with opioid use disorders could experience difficulty accessing treatment, which should be considered an essential treatment during the COVID-19 pandemic. The accelerated transition away from in person appointments and group therapy because of social distancing calls for health systems and community collaborations and adjustments …

Emerging Infections: The World Is Not Safe Until Countries Invest In Public Health Infrastructure. A Closer Look At Sub Saharan Africa (Ssa) Public Health Infrastructure During Covid-19 Pandemic., Liziana Nyakubaya

Master's Projects and Capstones

COVID-19 pandemic threatens public health systems across the globe. The ravaging COVID-19 virus does not spare public health systems of large economies such as the US. There are global shortages of PPE, laboratory, and critical care capacity is overwhelmed by the pandemic. Well-resourced public health care infrastructure is essential in reducing mortality, and disease burden in an epidemic, promoting global health security and safeguarding the progress made in other health programs such as HIV/AIDS and TB.

When public health care systems in high-income countries are struggling to manage COVID-19, the situation is worse for under-funded public health systems in SSA. …

Covid-19 Lockdown And Its Effect On The Children With Disabilities In Albania, Nesila Koka

International Programs

When the World slowly started to get invaded by Covid-19 “an infectious disease caused by a newly discovered coronavirus" (Coronavirus n.d.), Albania was also one of the countries, that wasn’t prepared at all. The lockdown officially lasted for 2 months (Mid-March - First weeks May) but for the children with disabilities it lasted longer than that, as schools closed by the end of May and the protocols for the daily centers to provide therapeutically services didn’t come out till the end of June. Unpreparedness of government lead un directly to retardation of development for the children with disabilities, with …