Regulation Of Innate Immune Responses To Rift Valley Fever Virus Infection Through Alternative Splicing Of Riok3, Thomas Charles Bisom

Graduate Student Theses, Dissertations, & Professional Papers

Work in this dissertation focuses on how innate immune responses are activated, dysregulated, evaded, and co-opted during Rift Valley fever virus (RVFV) infection. To better understand how innate immune responses are affected during RVFV infection, we placed a particular emphasis on understanding the functions of the atypical kinase RIOK3 in innate immune responses. RIOK3 was previously shown by our group and other groups to be involved in the antiviral type 1 interferon (IFN) and the inflammatory NFκB innate immune responses, but its exact functions in these responses were not clear. Prior research in our group also showed that RIOK3 mRNA …

Unm Health Sciences Center Data Book 2022-23, University Of New Mexico - Health Sciences Center

Health Sciences Center Databook (1990-ongoing)

No abstract provided.

Corrigendum: Characterization Of A Novel Transitional Group Rickettsia Species (Rickettsia Tillamookensis Sp. Nov.) From The Western Black-Legged Tick, Ixodes Pacificus, David T. Gauthier, Sandor E. Karpathy, Stephanie L. Grizzard, Dhwani Batra, Lori A. Rowe, Christopher D. Paddock

Biological Sciences Faculty Publications

No abstract provided.

Who Cares About Virtual Campus Tours? Virtual Tours In The College Choice Model And Perceived Student-Institution Fit, Christopher Thompson

Graduate Thesis and Dissertation 2023-2024

College recruitment practices have remained stagnant for quite some time. However, due to decreases in state funding and hypercompetitive applicant pools colleges must adapt their recruitment practices to remain competitive. Due to precautions and social distancing guidelines which occurred in 2020 caused by the coronavirus pandemic, college information sessions, college fairs, campus tours and other recruitment events were suspended. As such, admissions administrators were forced to rely on virtual recruitment practices, including virtual campus tours, to recruit applicants. Virtual campus tours allow colleges to expand their applicant pool by engaging with prospective students, who may not possess the required finances …

Analyzing Pulmonary Abnormality With Superpixel Based Graph Neural Networks In Chest X-Ray, Ronaj Pradhan

Dissertations and Theses

In recent years, the utilization of graph-based deep learning has gained prominence, yet its potential in the realm of medical diagnosis remains relatively unexplored. Convolutional Neural Network (CNN) has achieved state-of-the-art performance in areas such as computer vision, particularly for grid-like data such as images. However, they require a huge dataset to achieve top level of performance and challenge arises when learning from the inherent irregular/unordered nature of physiological data. In this thesis, the research primarily focuses on abnormality screening: classification of Chest X-Ray (CXR) as Tuberculosis positive or negative, using Graph Neural Networks (GNN) that uses Region Adjacency Graphs …

Privacy For Student-Patients: A Call To Action, Stacey A. Tovino

Emory Law Journal

Consider a law student who has a mental or reproductive health issue that the student wishes to keep private. If the student seeks care at an off-campus health clinic that is not affiliated with the student’s law school or university, the student typically has a number of federally enforceable privacy rights. For example, the federal HIPAA Privacy Rule will typically apply and prohibit the clinic from disclosing the student’s protected health information to professors, parents, and other third parties without the student’s prior written authorization. The law student also will have the right to receive a notice of privacy practices, …

A Systematic Review To Study The Global Patterns And Policies Of Hiv Harm Reduction Programs And Their Impact Among People Who Inject Drugs, Noura Shaltout, Rania Soliman, Lamia Refaey, Rim Ghazal, Mirna Atteya, Nahla Elmedany

Papers, Posters, and Presentations

Aim: This study aims to provide an updated estimate of HIV prevalence among people who inject drugs (PWID) globally, as well as investigate different policies and methods for applying harm reduction. This article focuses on the two major and the most frequently used harm reduction techniques, Syringe-Service Programs (SSPs) and Opioid Agonist Therapy (OAT). Methods: A comprehensive systematic review was undertaken across multiple international databases during the period of (August-December 2021). For studies conducted before 2005, we used data from a previous published systematic review. Thirty-six studies were included, including studies that had performed HIV testing and had a confirmed …

Placental Histopathological Changes In Covid-19 And Their Associated Effects On Adverse Pregnancy Outcomes, Eric Mugambi

Master of Medicine in Obstetrics and Gynecology

Introduction: Coronavirus disease (COVID-19) is a significant cause of morbidity and mortality among pregnant women. Pregnant women infected with SARS-CoV-2 are at a greater risk of pre-eclampsia/eclampsia, non-iatrogenic preterm birth, stillbirth, and small for gestational age infants/fetal growth restriction (SGA/FGR), which share a common placental etiology. Placental histopathological changes attributed to COVID-19 have been demonstrated but there is a knowledge gap in how these changes impact pregnancy outcomes particularly those of placental origin. Objectives: To investigate if there is an association between placental histopathology (maternal vascular malperfusion (MVM), fetal vascular malperfusion (FVM), acute and chronic inflammatory pathology, and other findings …

Effect Of Poor Menstrual Health On Uti Diagnosis, Michelle Muturi

Pitzer Senior Theses

Urinary Tract infections (UTIs) are microbial invasions of the urinary tract because of abnormal pathogen growth. They have short term symptoms like abdominal pain, fever and urinary frequency. Khayelitsha is a township that has a population of 2.4 million, 52% of which are women. This area is shaped by poor governance in South Africa that exacerbated medical issues due to a lack of resources. With lack of sanitary pad accessibility and knowledge of proper hygiene practices during the menstrual cycle, women are getting infected with UTIs 2-3 times a year. With an increase in antimicrobial resistance patterns, areas like Khayelistsha …

Health Behavior And Outlooks In An Altered Microbial Diversity: Changes In Parental Attitudes On ‘Building Immunity’ Throughout The Covid-19 Pandemic, Jennifer Vidal

Pitzer Senior Theses

The Covid-19 Pandemic in a short amount of time put into action disease control measures. Current literature has sought to address the long-term effects of sanitization efforts and social isolation on the diversity of the microbiome and the future of infectious diseases. Microbes – microorganisms such as bacteria, protozoa, algae, fungi, and viruses – inhabit the natural environment and human microbiome with our immune system, playing an essential role in immune regulation. The interplay between humans and microbes forms early immune development that has impacted parents’ attitudes toward microbes shown through their participation in Covid-19 preventative health practices. Using the …

Using Wastewater-Based Epidemiology To Study Chlamydia Occurrence On A College Campus, Jessie E. Chin Quee

Honors Undergraduate Theses

Chlamydia is a sexually transmitted disease caused by Chlamydia trachomatis, commonly affecting sexually active college-aged adults. Presently, opportunistic testing, self-testing, and information campaigns are methods to screen vulnerable populations and raise awareness about chlamydia. Chlamydia remains underdiagnosed and undertested due to a lack of participation by individuals who may have been exposed to it. Wastewater-based epidemiology is a rising biomonitoring tool that detects the presence of disease- and drug-specific biomarkers in a community's wastewater. In this study, wastewater-based epidemiology was used to detect the presence of C. trachomatis on the University of Central Florida campus. Wastewater samples were collected …

Trends In Antibiotic Susceptibility Of Staphylococcus Aureus Isolates In A Pediatric Hospital: An Analysis Of The Impact Of The Sars-Cov-2 Pandemic, Juan Miguel S. Gonzalez Rivero

Honors Undergraduate Theses

Infections caused by the organism Staphylococcus aureus are one of the most common causes for community-associated and healthcare-acquired infections (HAI). Isolates of this bacterium found within the healthcare setting often demonstrate a higher prevalence of antibiotic resistance making these infections difficult to treat. Historically, considerable focus has been placed on methicillin-resistant S. aureus (MRSA), which are strains resistant to β-lactam antibiotics like penicillin, oxacillin and cephalosporins; however, methicillin-sensitive (MSSA) strains may also possess resistance to several first-line antibiotics. Resistance to antibiotics can be acquired through horizontal gene transfer (HGT) by means of mobile genetic elements or by random DNA mutations …

Preparing College Students With Adhd For Online Job Interviews: Self-Regulation & Psychophysiology, Tahnee L. Wilder

Graduate Thesis and Dissertation 2023-2024

This dissertation investigates the complex dynamics of digital communication, highlights the unique stressors it places on college students with attention-deficit/hyperactivity disorder (ADHD), and advocates for adopting interdisciplinary methods to enhance their participation in online communication environments. While online interviewing has become increasingly common in the employment domain, it poses unique difficulties for individuals with ADHD, who may struggle with self-regulation and communication skills. Due to the absence of physical presence, online interviews pose a significant challenge to individuals in perceiving and responding to the nuanced range of non-verbal cues, which can greatly impact the effectiveness of their communication. To advance …

Use Of Seaweeds, Direct-Fed Microbial, And Nitrate To Mitigate Enteric Methane Emissions And Improve Health And Performance Of Dairy Cows, Diana Carolina Reyes Gomez

Doctoral Dissertations

Enteric methane (CH4) emissions from ruminants contribute significantly to global warming and represent a loss of dietary energy for the animal. Dietary manipulation is a promising approach for CH4 mitigation. Nitrate can effectively reduce CH4, but it can also be toxic in non-adapted ruminants. Supplementing with Paenibacillus fortis, a denitrifying probiotic strain, is a potential strategy to prevent toxicity. The interest in using macroalgae to mitigate CH4 emissions while improving animal health and production in ruminants has increased in recent years. The overall objective of this dissertation is to investigate nutritional-based strategies to mitigate enteric methane emissions and improve the …

Therapeutic Neutralizing Monoclonal Antibody Administration Protects Against Lethal Yellow Fever Virus Infection, Michael J. Ricciardi, Lauren N. Rust, Nuria Pedreño-Lopez, Sofiya Yusova, Sreya Biswas, Gabriela M. Webb, Lucas Gonzalez-Nieto, Thomas B. Voigt, Johan J. Louw, Fernanda D. Laurino, John R. Dibello, Hans-Peter Raué, Aaron M. Barber-Axthelm, Kimberly Chun, Samantha Uttke, Lidiane M. S. Raphael, Aaron Yrizarry-Medina, Brandon C. Rosen, Rebecca Agnor, Lina Gao, Caralyn Labriola, Michael Axthelm, Jeremy Smedley, Justin G. Julander, Myrna C. Bonaldo, Laura M. Walker, Ilhem Messaoudi, Mark K. Slifka, Dennis R. Burton, Esper G. Kallas, Jonah B. Sacha, David I. Watkins, Benjamin J. Burwitz

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Yellow fever virus (YFV) is a reemerging global health threat, driven by several factors, including increased spread of the mosquito vector and rapid urbanization. Although a prophylactic vaccine exists, vaccine hesitancy, supply deficits, and distribution difficulties leave specific populations at risk of severe YFV disease, as evidenced by recent outbreaks in South America. To establish a treatment for patients with severe YFV infection, we tested 37 YFV-specific monoclonal antibodies isolated from vaccinated humans and identified two capable of potently neutralizing multiple pathogenic primary YFV isolates. Using both hamster and nonhuman primate models of lethal YFV infection, we demonstrate that a …

Nsu Huizenga College Of Business And Entrepreneurship 2023-2024 Graduate Catalog, Nova Southeastern University

Huizenga Postgraduate Course Catalogs

No abstract provided.

Restorative Justice Diversion As A Structural Health Intervention In The Criminal Legal System, Thalia González

Journal of Criminal Law and Criminology

A new discourse at the intersection of criminal justice and public health is bringing to light how exposure to the ordinariness of racism in the criminal legal system—whether in policing practices or carceral settings—leads to extraordinary outcomes in health. Drawing on empirical evidence of the deleterious health effects of system involvement coupled with new threats posed by COVID-19, advocates and academics have increasingly called for race-conscious public health-driven reforms to carcerality in the United States. Recognizing the significance of health to carceral reform, the initiation of a health justice grounded lexicon in criminal justice has opened the doorway to new …

Barriers To Help-Seeking For Minority College Students During The Covid-19 Pandemic, Jasminder Bains

Public Health Theses

Background: The COVID-19 pandemic has profoundly impacted US college student mental health, but it is unclear how racial/sexual/gender minority students have specifically been affected. Traditional barriers to help-seeking such as mental health stigma do not necessarily hold the same influence in college student populations, and there is mixed evidence on what barriers are the most significant in this population. Therefore, the present study aims to ascertain the effects of the COVID-19 pandemic on the mental health outcomes of racial/sexual/gender minority college students and identify the largest barriers to care for college students.

Methods: Data were obtained from the 2020-21 Healthy …

Social Vulnerability And Viral Respiratory Infections In Connecticut (2018-2021): A Modeling Approach To Identify Salient Measures, Sarah C. Katsandres

Public Health Theses

The social vulnerability index (SVI) measure was developed by the Centers for Disease Control and Prevention to characterize a community’s vulnerability level. Recently, SVI has been used to predict risk of COVID-19, in order to understand which communities may be most vulnerable. This analysis aims to understand what factors are driving the relationship between census tract-level vulnerability and risk of hospitalization with a viral respiratory pathogen. A statistical analysis and modeling study of surveillance data was conducted, analyzing the incidence of hospitalization with influenza, respiratory syncytial virus (RSV), and COVID-19, by census tract, in two counties in Connecticut between 2018–2021. …

Scoping Review On Gonorrhea Vaccines, Linyang Li

Public Health Theses

Gonorrhea infection is caused by Neisseria gonorrhoeae and it is the second most common bacterial sexually transmitted infection around the globe. Although gonorrhea infection is treatable with antibiotics, the level of antimicrobial resistance continues to increase and has become a major public health concern. As options of available treatments are reduced by the emergence of AMR, it has become urgent to develop effective vaccines against gonorrhea infection. The purpose of this scoping review is to describe existing epidemiological evidence in support of gonorrhea vaccine development, to discuss the current vaccine candidates in clinical stages, and to evaluate the theoretical impact …

Shiga Toxin Producing Escherichia Coli (Stec) In Connecticut, Usa, 2017-2021, Angelo Raymond Lodato

Public Health Theses

Introduction: Shiga-toxin producing Escherichia coli (STEC) is a common foodborne pathogen known to cause significant gastrointestinal illness in humans and often results after contact with animals and/or consumption of food that has been contaminated. STEC is a major contributor of foodborne outbreaks in the US. Understanding major contributors of infection is important to improving prevention. Methods: Cases of STEC reported in routine Connecticut FoodNet surveillance were included. Trends in demographic features, serotypes, and exposure histories were used to assess whether there was variation among cases between 2017 and 2021, and pre (2017-2019) and post (2020-2021) COVID-19 pandemic. CT respondents of …

Cost-Effective Analysis Of Rotavirus Vaccination In Dhaka, Bangladesh Using A Dynamic Model Of Rotavirus Transmission, Anher Pinky

Public Health Theses

Background: Despite the global introduction of rotavirus vaccinations across countries, Rotavirus infections continue to be a

leading cause of severe, dehydrating gastroenteritis in children under the age of 5 (Crawford et al., 2017). Bangladesh

experiences an extremely high burden where rotavirus infections contribute to 6,000–14,000 deaths each year in children <5

years of age (Rahman et al., 2007). A cost-effective analysis can aid decision-makers in determining the pros and cons of

introducing a rotavirus vaccination program in limited-resource countries.

Objective: A cost-effectiveness analysis was developed to evaluate the potential benefits of introducing rotavirus vaccination.

The analysis performed aims to inform key …

“I Was Reaching Out For Help And They Did Not Help Me”: Mental Healthcare In The Carceral State, Anna Grace Preston

Public Health Theses

Background: Despite the limitations the carceral environment may impose on mental wellness, mental healthcare is increasingly becoming a carceral endeavor. Over the course of the last several decades, prisons and jails have become the de facto mental healthcare provider for thousands of incarcerated individuals. Furthermore, practices like mandated mental healthcare for supervised individuals further broaden the population experiencing mental healthcare within the criminal legal system at large. This study examines the perspectives of nine individuals who experienced mental healthcare within the carceral state, whether in prison or on parole or probation, with a special focus on how attributes of the …

The Undercurrents Of Disease In Armed Conflict: An Analysis Of Aggregate National Dstb And Mdr/Xdr Tb Screening & Diagnosis Trends During The 2022 War In Ukraine, Sakina Erika Reames

Public Health Theses

​​Tuberculosis (TB) is the second leading cause of death by an infectious disease worldwide after COVID-19. Extensive efforts have been made for decades to tackle this disease through bolstering healthcare systems especially in countries experiencing a disproportionate burden of TB. Ukraine is considered by the WHO to be one of the 30 high burden countries in the world with a notably high burden of MDR TB. In addition, Ukraine has the second largest HIV epidemic in Eastern Europe and Central Asia as well as the fifth largest number of extensive drug resistant cases in the world. Ukraine has made extensive …

Developing And Using Cholera Models In Northwest Syria, Emily Rose Tobik

Public Health Theses

Researchers have utilized transmission dynamic modeling to determine interactions between hosts and pathogens in many humanitarian settings. However, modeling for the cholera outbreak in Northwest Syria (NWS) has yet to be completed. This thesis presents a path towards cholera model building in NWS by investigating the current cholera outbreak, outlining how to create a compartmental model in this region given its complexities, and determining ways potential cholera models could be utilized in NWS. Intricacies involving the region's ongoing civil war, significant internally displaced persons (IDP) population, and the February 2023 earthquake add complexities to modeling in this region. For the …

Diversity Of Blood-Sucking Insects And Vector-Borne Diseases In Pig Farms In Thailand, Kritsada Thongmeesee

Chulalongkorn University Theses and Dissertations (Chula ETD)

Vector-borne diseases (VBDs) have been recognized as important diseases in humans and animals across the globe. Blood-sucking insects, such as mosquitoes, tabanid flies, and stable flies may carry pathogens, transmit, and cause VBDs in hosts, including pigs. In Thailand, most of the pig farms have backyard system implying that pigs could be easily exposed to blood-sucking insects and lead to infection with vector-borne pathogens (hemoplasmas, Japanese encephalitis virus (JEV), and Trypanosoma (T.) evansi). However, the information about vector-borne pathogens in pigs in Thailand needs to be updated. The objectives of this dissertation were to study the occurrence and genetic diversity …

Utilizing Outpatient Telehealth As A Treatment Approach For Patients With Substance Use Disorder: A Quality Improvement Project, Veronica Kwegyir-Afful

DNP Scholarly Projects

Background: The issue of substance use disorder (SUD) has demonstrated a growing prevalence both in the United States (U.S.) and globally. Effective treatment modalities have been devised for individuals afflicted by SUD, thereby enabling their post-treatment prognosis to be parallel to that of patients with other chronic diseases, such as diabetes. However, several factors or barriers impede individuals with SUD from assessing treatment. These barriers encompass financial constraints stemming from inadequate insurance coverage and high cost, the stigma surrounding SUD, which results in patient's hesitancy to seek treatment treat, adverse societal attitudes, collateral social percussions like work hour losses and …

Epidemiology Of Sars-Cov-2 Breakthrough Infections In Kentucky March 1st 2021 - December 31st, 2022, Harrison Hynes

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Objective: Provide epidemiologic overview of SARS-CoV-2 breakthrough infections in Kentucky considering both demographic and geographic variables.

Background: We believe descriptive information of breakthrough cases for a defined population will provide public health practitioners with useful information relating to SARS-CoV-2 infection control and vaccination efforts.

Methods: We obtained SARS-CoV-2 case data from the Kentucky Department for Public Health COVID-19 case repository, which mirrors National Electronic Disease Surveillance System (NEDSS) data. The study sample used for analysis comprised 147,000 individuals who tested positive for SARS-CoV-2 in Kentucky between the dates of March 1^st, 2021 and December 31^st, 2022. …

Strategies To Mitigate Nurse Turnover, James Edward Cooper Jr

Walden Dissertations and Doctoral Studies

Registered nurse turnover is a severe problem for all healthcare organizations because it negatively affects financial growth, patient care, and reputation, ultimately resulting in financial losses. Grounded in Herzberg’ two-factor theory, the purpose of this qualitative multiple-case study was to explore strategies hospital leaders use to mitigate RN turnover. The participants included three hospital leaders from three different hospitals in the southeastern United States who mitigated RN turnover. Data were collected from semistructured interviews and company documents and analyzed using Yin’s five-phase data analysis process. Three themes emerged: nurse engagement, job satisfaction, and trust in leadership mitigated RN turnover. A …

An Association Of The Transgenerational Implications Of Redlining And Obesity On Pediatric Type Ii Diabetes, Carlin Dexter Nelson

Walden Dissertations and Doctoral Studies

s the prevalence and incidence of childhood obesity has increased, so has the number of cases of pediatric Type 2 diabetes mellitus (T2DM). Although made unconstitutional in 1968, the transgenerational implications of redlining can be observed in disinvestments resulting in neighborhood detraction. Utilizing the 2019–2020 National Children’s Health Survey, the purpose of the study was to evaluate the relationship between obesity, T2DM, and neighborhood detraction elements as well as assessed indicators of T2DM in non-institutionalized children 6 through17 years of age (N = 34,725). The social determinants of health perspective served as the conceptual framework for the study. Results indicated …