Digital Commons Network^™

Almajiri Health; A Scoping Review On Disease, Health Literacy And Space For Participatory Research, Muzzammil Imran Muhammad

Yale Medicine Thesis Digital Library

Introduction

Almajirai are male children who leave the care of their parents to learn the Qur’an and study Islam under the tutelage of a Mallam or Imam at a Tsangaya. Almajiranci refers to the system of education based on this relationship between almajiri and mallam, and which was the dominant mode of education in precolonial Hausaland – Northern Nigeria and Southern Niger. This system remains widespread and popular in both countries. In recent years, discourse around almajirai has featured prominently in media from and about this region, and has associated almajiranci with non-participation in formal education, abuse, poverty, and underdevelopment. …

“I Was Reaching Out For Help And They Did Not Help Me”: Mental Healthcare In The Carceral State, Anna Grace Preston

Yale Medicine Thesis Digital Library

Background: Despite the limitations the carceral environment may impose on mental wellness, mental healthcare is increasingly becoming a carceral endeavor. Over the course of the last several decades, prisons and jails have become the de facto mental healthcare provider for thousands of incarcerated individuals. Furthermore, practices like mandated mental healthcare for supervised individuals further broaden the population experiencing mental healthcare within the criminal legal system at large. This study examines the perspectives of nine individuals who experienced mental healthcare within the carceral state, whether in prison or on parole or probation, with a special focus on how attributes of the …

Active Adult Communities, A Master Plan Design For Independent Living Communities In Arlington, Texas, Cooper Begis

Landscape Architecture Masters & Design Theses - Archive

The purpose of this qualitative study is to design a master plan for independent living communities that will include the development of amenities, natural features, and connections, which encourage physical and social engagements within their living arrangements.

Creating landscapes that promote Active Living has been a trending topic explored over the last couple of decades. The World Health Organization defines this as, “A way of life in which physical, social, mental, emotional and spiritual activities are valued and are integrated into daily living.” (WHO, 2023) Providing these spaces encourages opportunities to interact and engage with others of similar ability. In …

A Qualitative Study Of Moral Distress In Physicians During The Covid-19 Pandemic, William Washington

Walden Dissertations and Doctoral Studies

Abstract The spread of Coronavirus (COVID-19) created a pandemic and had a world-shattering effect on healthcare organizations. As a result, many healthcare professionals were exposed to health situations that stretched them beyond their professional ethics, mental health, and emotional capacity. Throughout the last 30 years, moral distress has been understood as the type of stress that medical professionals experience. Research has substantially grown regarding COVID-19 and moral distress, exposing gaps in the ability of experts to care as they should. Moral distress was a term created to define the emotional disruption that occurs when a professional cannot work within their …

A Quantitative Study On Molecular Cluster Detection In Virally Suppressed Communities, Mariska Belinda Osborne-Wells

Walden Dissertations and Doctoral Studies

Viral suppression within human immunodeficiency virus (HIV) care and treatment planning is the gold standard of care for most providers when engaging with their patients. In many settings, the patient has received a positive lab that is indicative of HIV antibodies being detected; this in turn means they need additional medical attention to manage the infection. Upon receiving linkage to care services and attending an initial appointment, an initial genetic sequence is usually completed to assess the patient’s strain of HIV and how antiretroviral medications may antagonize or complement the HIV strain. It is possible that access, bias, and colorism …

Covid-19 And Its Impact On Nursing Care Facility Business Operations: A Phenomenological Inquiry, Lashonda Bonsu

Walden Dissertations and Doctoral Studies

AbstractThe research problem was the lack of knowledge regarding how nursing care facility leaders sustained business operations within the climate of adversity created by the COVID-19 pandemic. The purpose was to explore and understand the essence of nursing care facility leaders’ perceptions and experiences in maintaining business operations during the COVID-19 pandemic. The conceptual framework was based on resiliency theory. The central research question and subquestion for this qualitative transcendental, phenomenological study focused on what strategies nursing care facility leaders use to sustain business operations during the COVID-19 pandemic, as well as their perceptions and experiences regarding their response to …

Digital Twins For Ancillary Transportation Asset Data Management, Ashtarout Ammar

Theses and Dissertations--Civil Engineering

Transportation Asset Management (TAM) is a data-driven decision-making process to maintain and extend the serviceability of transportation assets throughout their lifecycle. TAM is an extensive data process requiring accurate, high-quality information for better decision-making. A significant challenge that state Departments of Transportation (DOTs) face is allocating limited funds to optimize their assets’ performance. The criticality of this challenge increases when state DOTs need to manage a wide variety of assets distributed along with a vast network; thus, they prioritize the management of high-value assets and visible ones such as bridges, and they pay less attention to ancillary assets even though …

Investigating The Relationship Between Metabolic Reprogramming And Peripheral Cd4+ T-Cell Inflammation In Human Type 2 Diabetes Pathogenesis, Gabriella Kalantar

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

Chronic, low-grade systemic inflammation rises in obesity and promotes type 2 diabetes (T2D). Circulating immune cells are key indicators of obesity and T2D pathogenesis. T cells outnumber monocytes, in blood, suggesting that T cells might fuel peripheral inflammation in obesity/T2D. Our lab’s work supports this idea by identification of a Th17 cytokine profile in T2D from T-cell stimulated peripheral blood mononuclear cells. Work described herein further supported this work by demonstrating that T cells dominate peripheral inflammation over monocytes across the spectrum of obesity and glycemic control. Our lab has also recently shown that inflammation changes during prediabetes (preT2D), identified …

Striving For Appropriate Antibiotic Use: A Biomarker Initiative, And Outcomes Associated With Azithromycin Exposure, Amanda Gusovsky

Theses and Dissertations--Pharmacy

The introduction of antibiotics into clinical practice is considered the greatest medical breakthrough of the 20^thcentury. However, the use of antibiotics can contribute to the development of resistance. In the United States (U.S.), approximately 2.8 million people are infected with antibiotic-resistant bacteria each year, and more than 35,000 people die as a result. Moreover, some antibiotics are known to cause cardiac side effects including QT prolongation, hypotension, and ventricular arrythmias. The U.S. Centers for Disease Control and Prevention (CDC) defines appropriate antibiotic use as the effort to use “the right antibiotic, at the right dose, for the right …

Investigation Of Folate-Poly(Glutamic Acid)/Polyethylenimine/Dna Complexes For In Vitro Gene Delivery, Caleb Akers

Theses and Dissertations--Pharmacy

Gene therapy is currently being studied as a treatment for a variety of indications, including cancer, infectious disease, and cardiovascular diseases, among others. While many of the early treatments in the field involved the use of viral delivery methods, various safety, ethical, and financial concerns limit the potential uses of this methodology. As such, more recent research has focused on developing non-viral delivery platforms to alleviate some of the issues inherent in viral delivery. Recently, the release of the COVID-19 vaccines from Pfizer and Moderna represents a promising use of non-viral delivery as both utilized a lipid-based delivery vector.

Despite …

Developing A Biocatalytic Toolbox To Aid In Understanding Nucleoside Antibiotics, Jasmine Brianna Woods

Theses and Dissertations--Pharmacy

Antibiotic resistance happens when bacteria develop the ability to survive medications that normally terminate them. Instead, these super germs are able to survive in the body and produce a community of antibiotic resistance germs which can cause human fatalities. It is important to discover and develop new compounds and molecules that will improve this clinical obstacle. This research focused on analyzing the biosynthesis that incorporates distinctive chemical characteristic of various nucleoside antibiotics, ß-hydroxy amino acids and α-methyl-amino acids. ß-hydroxy amino acids and α-methyl-amino acids are considered an important class of industrially useful compounds, particularly for pharmaceutical development, and are found …

Relative Adrenal Insufficiency In Sepsis, Dan Hao

Theses and Dissertations--Pharmacology and Nutritional Sciences

Sepsis is a leading cause of death in children. Glucocorticoid (GC) therapy had been strongly recommended for the pediatric sepsis (grade 1A). However, the recommendation was changed to grade 2C in 2020 due to weak evidence. Relative adrenal insufficiency (RAI) is a condition characterized by impaired inducible glucocorticoid (iGC) production in response to stress. It develops in 32.8% of pediatric septic patients. Unfortunately, little is known about the pathogenesis of RAI in pediatric sepsis, and whether GC therapy should be based on the status of RAI is controversial. In this study, we utilized 21-day-old SF1CreSRBI^fl/fl mice as the first …

Age-Associated Increase Of Gamma Delta T Cells In Visceral Adipose Tissue And Mechanisms Of Their Accumulation, Sujata Mukherjee

Theses and Dissertations--Pharmacology and Nutritional Sciences

Chronic systemic inflammation, known as inflammaging is considered a hallmark of aging and associated diseases. While adipose tissue has long been considered only as a caloric reservoir regulating systemic energy homeostasis, research in the past couple of decades substantiate its endocrine function to secrete an array of inflammatory mediators and hormones, which have physiological effects on multiple organ systems, and contribute to inflammaging. Redistribution of adipose tissue from subcutaneous to visceral depots, changes in the immune profile and the chronic inflammatory state are among the major sources of adipose tissue dysfunction with aging.

This dissertation is focused on identifying and …

Sex Dimorphisms Of Aldosterone And High Salt Induced Aortic Aneurysms In Mice, Xufang Mu

Theses and Dissertations--Pharmacology and Nutritional Sciences

Aortic aneurysms, a permanent enlargement in the aorta, is a devastating disease with a high mortality rate after rupture. Aortic aneurysms exhibit strong sex dimorphisms: men are at higher risk than women while women experience worse outcomes if diagnosed. Currently, the only intervention is by open surgery or endovascular repair, and no drugs are approved for blunting the disease progression. This highlights the needs for mechanistic studies for sex-specific therapeutic targets.

Our lab established the mouse model in which mineralocorticoid receptor (MR) agonist aldosterone induces aortic aneurysms in the presence of high salt in male mice age-dependently, mimicking the aging …

Exploring The Distinction Between Support And Enabling In Families With Substance Use Disorder, Krystal N. King

Theses and Dissertations--Family Sciences

Substance use disorders (SUD) are a pervasive public health problem facing families in the United States. Although families are frequently urged to support loved ones who have SUD and cautioned against enabling them, there is a dearth of literature that distinguishes between supporting and enabling. Through qualitative interviews, this phenomenological study examined the experiences of eight parents with adult children with SUD who were currently in recovery. Five themes emerged from the data including: (a) living in despair, (b) addiction and recovery knowledge, (c) support group philosophy, (d) coping with addiction, and (e) differentiation. The results from this study suggest …

Equine Fecal Microbiota Response To Short Term Antibiotic Administration, Jordan Lacey Parker

Theses and Dissertations--Veterinary Science

Though generally regarded as safe, research continues to demonstrate negative side effects of antibiotic administration on the gastrointestinal (GIT) microbiota across species. In horses, antibiotic associated diarrhea (AAD) is a life-threatening side effect linked to the GIT microbiota. This study tested the hypothesis that short term antibiotic administration to healthy horses would negatively impact the fecal microbiota as measured by their ability to digest nutrients and produce short chain fatty acids (SCFAs). Twenty-four horses were assigned to one of four treatments: control (CO); potassium penicillin/gentamicin sulfate (KPG); ceftiofur crystalline free acid (EX); trimethoprim/sulfamethoxazole (SMZ); and treated for 4 days. Fecal …

Receptor Usage And Infection Biology Of Influenza D Virus, Tirth Uprety

Theses and Dissertations--Veterinary Science

Influenza D virus (IDV) utilizes bovines as a primary reservoir with periodical spillover to other hosts. We have previously demonstrated by the traditional hemagglutination assay coupled with sialoglycan microarray and functional assays that IDV can recognize and bind both 9-O-acetylated N-acetylneuraminic acid (Neu5,9Ac₂) and 9-O-acetylated N-glycolylneuraminic acid (Neu5Gc9Ac). Agricultural animals such as cattle can produce both Neu5,9Ac₂ and Neu5Gc9Ac, while humans are genetically unable to synthesize Neu5Gc9Ac. The bifunctional enzyme, glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE) is a master regulator of de-novo sialic acid synthesis while 9-O-Acetylation of sialic acids is catalyzed by …

The Effect Of Land-Cover/Land-Use And Habitat Fragmentation On Spatial Patterns Of Lyme Disease In The Eastern United States, Maria Elizabeth Topmiller

Theses and Dissertations--Forestry and Natural Resources

Lyme disease has been of national concern for the past few decades. As our understanding of the role of landscape structure in epidemiology expands, it is essential to apply the principles of landscape ecology to the research of vector-borne and zoonotic disease. This study examined the strength of the relationship between land-cover class, degree of habitat fragmentation and county-level Lyme disease cases. Forest, agricultural, and urban land cover types were the categories of interest, while percent cover, edge density, and patch density were the landscape metric used to measure habitat amount and fragmentation. The general linear trends were modelled with …

Fate And Transport Of Emerging Contaminants Entering, Leaving, And Flowing Past Wastewater Treatment Plants In Central Kentucky, Kyra Sigler

Theses and Dissertations--Biosystems and Agricultural Engineering

Per- and polyfluoroalkyl substances (PFAS) and neonicotinoid insecticides are two classes of emerging contaminants that have been recently detected in many environmental compartments. Both have been associated with negative impacts on humans and the environment. Wastewater treatment plants (WWTPs) have been identified as likely hotspots for introduction of these contaminants into the environment. Thus, the aim of this study was to investigate the occurrence of PFAS and neonicotinoids in two WWTPs in Central Kentucky. Polar organic chemical integrative samplers (POCIS) were deployed in WWTP influent and effluent and placed upstream and downstream of the effluent mixing zone (EMZ) for two …

Surveillance For Ticks And Tick-Borne Pathogens In Kentucky, Anna Rosalee Pasternak

Theses and Dissertations--Entomology

Tick-borne diseases are an emerging threat to human and animal health. In Kentucky, tick-borne disease surveillance has identified rising incidences of spotted fever rickettsiosis, ehrlichiosis, and Lyme disease. Since these diseases occur through the bites of infected ticks, effective prevention efforts are reliant upon knowing where the risk of exposure to tick bites exists. Historical data on tick distribution in Kentucky is variable, with very little reported on a statewide scale, leaving vector control workers, public health personnel, physicians, veterinarians, and others to rely on outdated, intermittent, or out-of-state information. In my dissertation, I surveyed ticks and select tick-borne pathogens …

Trauma-Informed Care: A Collaborative Strategy To Address Hiv-Infection Rates Among Black Gay And Bisexual Men, Willie T. Boddie Jr.

DSW Capstone Projects

The Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (HIV/AIDS) continues to be an epidemic among gay and bisexual men or men who have sex with men (MSMs). For Black MSMs, the HIV infection rate is disproportionate compared to the number of Black or African American citizens in the U.S. Black MSMs have the highest HIV infection rate in the U.S. This Capstone Project seeks to explore the possible impact of trauma experiences among this group and determine how providing trauma-informed care, along with the standard HIV education and awareness can be used to effectively reduce this disparity and ultimately …

Childhood Vaccination Crisis: A Constitutional Analysis Of New York’S Response To Abuse Of The Religious Exemption, Megan O’Boyle

Student Works

No abstract provided.

Digital Contact Tracing – Is It Worth The Hype?#, Miruh Linda Jeon

Student Works

No abstract provided.

Taking Care Of Business: An Empirical Examination Of The Top S&P 500 Companies And Their Role As Public Health Regulators During The Covid-19 Pandemic, Megan M. O’Malley

Student Works

No abstract provided.

Examining The Immune Regulation Of Nlrp12 Through Novel Protein Interactions, Catherine Rippe

Graduate Theses/Dissertations

NOD-like receptors (NLRs) are intracellular proteins that play an important role in the regulation of the innate immune response to pathogens. Since being identified, various functions for NOD-like receptor pyrin domain containing 12 (NLRP12) have been suggested. It has been shown to negatively regulate the inflammatory response through canonical and noncanonical NF-kB signaling pathways, control tumorigenesis and gut homeostasis and exacerbate inflammation through the formation of a multi-protein complex called an inflammasome. Due to the varying roles established for NLRP12, the mechanisms by which it functions remain poorly understood. In this study, I sought to confirm a novel protein-protein interaction …

The Impact Of Social Connection And Psychological Resilience On Covid-19 Pandemic- Related Mental Health Outcomes, Shelby Lee Powers

Doctor of Psychology (PsyD)

The COVID-19 pandemic has had wide reaching, well-documented impacts on mental health across demographics. Among these impacts are higher rates of depression and anxiety in adults. Several factors have been shown to mitigate the experience of depression and anxiety, including social connection and psychological resilience. The present study examined social connection and psychological resilience as predictors of depression and anxiety on a U.S. adult sample (n = 535) during the COVID-19 pandemic. Participants were recruited using Qualtrics. Results of this study described that over 30% of the variance in anxiety and depression was predicted by a person’s levels of social …

Modeling Behavior And Vaccine Hesitancy For Predicting Daily Vaccination Inoculations Using Trends, Case, Death, And Twitter Sentiment Data, Talal Daghriri

Electronic Theses and Dissertations, 2020-2023

Over the past 100 years, epidemiological models have evolved to incorporate greater facets of the process. With the advent of social networking, massive computational power, population sentiment analysis can now be added to the epidemiological modeling process. Sentiment analysis is greater understanding of the fears, uncertainties, motivation, and trends of the public with respect to vaccination and associated events. Lack of public confidence in the efficacy of models, safety of vaccines, and appropriateness of policies confounds vaccine inoculation prediction. Sentiment analysis of social media is a seminal technique that accesses shared users' contents and tweets on the Twitter platform for …

The Role Of K-12 Schools As Essential Public Health Partners, Wendy Kutten, Naa-Amy Wayne, Samuel T. Opoku, Bettye Apenteng

Eagles Talking About the Public’s Health

No abstract provided.

Covid-19 Vaccination And Alcohol Consumption: Justification Of Risks, Pavel A. Solopov

Bioelectrics Publications

Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, pharmaceutical companies and research institutions have been actively working to develop vaccines, and the mass roll-out of vaccinations against COVID-19 began in January 2021. At the same time, during lockdowns, the consumption of alcoholic beverages increased. During the peak of vaccination, consumption remained at high levels around the world, despite the gradual relaxation of quarantine restrictions. Two of the popular queries on search engines were whether it is safe to drink alcohol after vaccination and whether this will affect the effectiveness of vaccines. Over the past two …

Artificial Intelligence In Public Health Dentistry, Bhinika Wadher, Priyanka Paul Madhu, Abhinn Miglani, Janhavi Buldeo

International Arab Journal of Dentistry

The creation of the relevant technology must be driven by educational demands. Even so, the human factor must always be taken into consideration. Exciting new technology and potent cures will continue to be produced by scientific research. The capacity of a digital computer, computer-controlled robot to carry out actions closely identified with intelligent beings is known as artificial intelligence (AI). The evolution of AI has been clearly accelerating over the past ten years, and dentistry has not been an exception. Dental AI is important for diagnosing patients, storing patient data, and evaluating genetic information to improve patient treatment. This applies …