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Relationship Between Homelessness, Substance Use, Employment, Living On A Reservation And Tuberculosis Among Northern Plains Native Americans, Darla Mccloskey Jan 2023

Relationship Between Homelessness, Substance Use, Employment, Living On A Reservation And Tuberculosis Among Northern Plains Native Americans, Darla Mccloskey

Walden Dissertations and Doctoral Studies

Native Americans in the Northern Plains have a long history of tuberculosis (TB) infections. There is limited research on the causes of latent TB infections (LTBI) and TB in this population. The purpose of this quantitative study was to assess the relationship between latent TB and factors of homelessness, substance use, employment, living on a reservation, and active or latent TB among this population using the eco-social theory as the theoretical framework. Data from 146 TB cases of Native Americans living in the Northern Plains and diagnosed with TB from 1999 to 2019 were analyzed using chi-square tests that showed …

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The Relationship Between Chlamydia, Gonorrhea, Syphilis And Race, Gender, And Age, Johnny James Mcgrew Jan 2023

The Relationship Between Chlamydia, Gonorrhea, Syphilis And Race, Gender, And Age, Johnny James Mcgrew

Walden Dissertations and Doctoral Studies

The purpose of this quantitative correlational design using secondary data from Colorado Department of Public Health and Environment was to examine the relationship between different types of sexually transmitted infections (STIs), specifically, chlamydia, gonorrhea, and syphilis, and race, gender, and age in the United States. This study is significant because it could assist medical personnel to focus on more personally-based STI treatments. This study could also lead to a call for more research regarding sexual health programs across the nation, individuals’ willingness to share personal information regarding STIs, and how sexual health programs could increase testing for STIs. The study …

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Strategies To Mitigate Inappropriate Test Utilization By Physicians To Improve Efficiency In A Healthcare Setting, Christine C. Wood Jan 2023

Strategies To Mitigate Inappropriate Test Utilization By Physicians To Improve Efficiency In A Healthcare Setting, Christine C. Wood

Walden Dissertations and Doctoral Studies

Inappropriate test utilization by physicians for clinical decision-making in patient care is a significant problem facing some healthcare leaders. Healthcare leaders are concerned about inappropriate test utilization because it can increase healthcare costs and degrade patient outcomes. Grounded in the complex adaptive system and Lean Six Sigma conceptual frameworks, the purpose of this qualitative single-case study was to identify strategies seven hospital leaders in Maryland and Washington, DC. who implemented successful test utilization strategies for physicians. Data were collected from semistructured virtual interviews and organizational reports and analyzed using Yin’s 5 step process. Five themes emerged: (a) continuing physician education, …

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Primary Teacher Experiences With Kinesthetic And Tactile Learning In Virtual Settings, Audrey Lorraine Bryant Jan 2023

Primary Teacher Experiences With Kinesthetic And Tactile Learning In Virtual Settings, Audrey Lorraine Bryant

Walden Dissertations and Doctoral Studies

The primary grade levels traditionally consist of highly kinesthetic and tactile activities supporting learning and student engagement. During the COVID-19 pandemic, teachers urgently transitioned these learning activities to virtual settings. However, research shows a need for more literature on primary teacher experiences and their move toward innovative learning activities during the COVID-19 pandemic. The purpose of this study was to explore primary teacher experiences with kinesthetics and tactile activities in virtual settings. The combined conceptual framework of the study were Dewey’s theories on active learning and Siemens’ theory on the changing curriculum and learning in virtual settings. Eight primary teachers …

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The Impact Of Technology, Engagement, And Student Readiness On Student Learning In Blended Synchronous Learning Environments, Kirsten Passyn, Susan Wright Jan 2023

The Impact Of Technology, Engagement, And Student Readiness On Student Learning In Blended Synchronous Learning Environments, Kirsten Passyn, Susan Wright

Atlantic Marketing Journal

The authors investigate technology, engagement, and student readiness as determinants of student learning in a blended synchronous learning environment. The experiment was conducted in two sections of a principles of marketing course where in-person and remote students simultaneously completed short concept quizzes using a mobile polling app. In-person students achieved higher quiz scores than remote students. GPA is a predictor of scores in both environments, and the effect is more pronounced for lower GPA students in remote locations. Student surveys identify focus and engagement as primary challenges to remote learning. Technology issues are secondary.

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The Relationship Between Parasite Infection, Body Condition, And Migration In White-Crowned Sparrows And California Towhees, Madeline Galbraith Jan 2023

The Relationship Between Parasite Infection, Body Condition, And Migration In White-Crowned Sparrows And California Towhees, Madeline Galbraith

CMC Senior Theses

Long-distance animal migration plays a large role in the spread of infectious disease, potentially causing an increase or a decrease in infection. These outcomes can be serious, as infection has the ability to induce a variety of effects on the host, all which may impact their overall health. The consequences of infection on a host can be measured using body condition. Changes to an individual’s body condition are central to the mechanisms involved in migration’s ability to both increase (ex: susceptibility) and decrease infection (ex: migratory culling). Therefore, when assessing potential migratory effects, it is important to consider relationships between …

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Visualization And Characterization Of The Immunological Synapse Between Chlorotoxin Chimeric Antigen (Cltx-Car) Redirected T Cells And Targeted Glioblastoma Tumors, Arianna Livi Jan 2023

Visualization And Characterization Of The Immunological Synapse Between Chlorotoxin Chimeric Antigen (Cltx-Car) Redirected T Cells And Targeted Glioblastoma Tumors, Arianna Livi

CMC Senior Theses

Chimeric Antigen Receptor T (CAR-T) cells have demonstrated anti-tumor activity against aggressive and invasive cancers such as glioblastoma (GBM); however, clinical response rates remain low in clinical trial studies. Tumor heterogeneity and tumor microenvironment conditions pose significant challenges for treatment of GBM, thus continuous optimization of CAR-T cell therapies and identification of novel, widely expressed, and highly specific GBM antigens are vital to better patient outcomes. A newly developed CAR-T cell construct incorporating chlorotoxin (CLTX) as the targeting domain exhibited broad GBM-targeting capabilities and elicited potent cytotoxic effects during preclinical studies and is currently being tested in a phase I …

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Exploring How Determinants Of The Gender Wage Gap In The United States Have Changed Women’S Wages Over Time, Highlighting Changes During The Covid-19 Period, Vikram Chatterjee Jan 2023

Exploring How Determinants Of The Gender Wage Gap In The United States Have Changed Women’S Wages Over Time, Highlighting Changes During The Covid-19 Period, Vikram Chatterjee

CMC Senior Theses

Using IPUMS Current Population Survey (CPS) and CPS Annual Social and Economic Supplement (ASEC) microdata, new empirical evidence is presented on the changing levels and trends in the gender wage gap from 2009 to 2022, including a COVID-19 specific analysis. Based on the empirical research study performed in this paper, three main conclusions can be identified. First, when controlling for standard wage explanatory variables, the gender wage gap reduced during COVID-19, as women increased their wages by 3.12% relative to men. This is opposed to predictions from Alon et al. (2020) who projected the wage premium for men would rise …

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Stressors And Hormone Levels: Predictors Of Covid-19 Health Outcomes In Latine Adults, Wendy Rodriguez Jan 2023

Stressors And Hormone Levels: Predictors Of Covid-19 Health Outcomes In Latine Adults, Wendy Rodriguez

CMC Senior Theses

The Coronavirus 2019 Disease (COVID-19) has been shown by multiple studies to have disproportionate impacts on some individuals, especially minority populations. These may be attributed to differences in biological (sex), gender, social or cultural factors. In this study, we aim to identify and investigate the gender and social predictors that may be involved in the pathogenesis of the virus and its health outcomes. To achieve this, a literature review expands on relevant topics that better contextualize COVID-19’s complex nature. The potential role of hormones, estrogen, and testosterone is considered across different sexes and genders as protective agents against COVID-19. This …

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Chemotherapy Induced Myelosuppression After First Cycle Of Adjuvant Chemotherapy For Non- Metastatic Breast Cancer, Marwa Mohammed, Adil Al Aqabi Jan 2023

Chemotherapy Induced Myelosuppression After First Cycle Of Adjuvant Chemotherapy For Non- Metastatic Breast Cancer, Marwa Mohammed, Adil Al Aqabi

Iraqi Postgraduate Medical Journal

BACKGROUND: Breast cancer is the most common cancer in women. Chemotherapy makes cancer patients at risk of developing myelosuppression which may cause delay in treatment and dose reduction.AIM OF THE STUDY: To assess tendency for chemotherapy induced cytopenia after the first cycle of chemotherapy in non-metastatic breast cancer patients.PATIENTS AND METHODS: A prospective observational study included 152 patients diagnosed with breast cancer and planned to receive adjuvant chemotherapy in form of Adriamycin / cyclophosphamide (AC) based chemotherapy, all of them with normal complete blood count pre chemotherapy and were observed by recording their absolute neutrophil count, hemoglobin and platelet count …

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Food And Drug Regulation: Statutory And Regulatory Supplement (2023), Adam I. Muchmore Jan 2023

Food And Drug Regulation: Statutory And Regulatory Supplement (2023), Adam I. Muchmore

Faculty Scholarship

This Statutory and Regulatory Supplement is intended for use with its companion casebook, Food and Drug Regulation: A Statutory Approach (2021). This is not a traditional statutory supplement. Instead, it contains selected, aggressively edited provisions of the Federal Food, Drug and Cosmetic Act (FFDCA), related statutes, and the Code of Federal Regulations. The Supplement includes all provisions assigned as reading in the casebook, as well as a few additional provisions that some professors may wish to cover. The excerpts are designed to be teachable rather than

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‘A Most Equitable Drug’: How The Clinical Studies Of Convalescent Plasma As A Treatment For Sars-Cov-2 Might Usefully Inform Post-Pandemic Public Sector Approaches To Drug Development, Quinn Grundy, Chantal Campbell, Ridwaanah Ali, Matthew Herder, Kelly Holloway Jan 2023

‘A Most Equitable Drug’: How The Clinical Studies Of Convalescent Plasma As A Treatment For Sars-Cov-2 Might Usefully Inform Post-Pandemic Public Sector Approaches To Drug Development, Quinn Grundy, Chantal Campbell, Ridwaanah Ali, Matthew Herder, Kelly Holloway

Articles, Book Chapters, & Popular Press

Interventional clinical studies of convalescent plasma to treat COVID-19 were predominantly funded and led by public sector actors, including blood services operators. We aimed to analyze the processes of clinical studies of convalescent plasma to understand alternatives to pharmaceutical industry biopharmaceutical research and development, particularly where public sector actors play a dominant role. We conducted a qualitative, critical case study of purposively sampled prominent and impactful clinical studies of convalescent plasma during 2020-2021. We found that studies were mobilized and scaled at record pace due to well-connected investigators who engaged in widespread sharing of clinical trials resources, regulatory facilitators, and …

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Factors That Impact Assigned Female Sexual Minority Individuals Health Care Experiences: A Qualitative Descriptive Study, Maureen Rabbitte, Maithe Enriquez Jan 2023

Factors That Impact Assigned Female Sexual Minority Individuals Health Care Experiences: A Qualitative Descriptive Study, Maureen Rabbitte, Maithe Enriquez

Faculty Publications - Mennonite College of Nursing

This qualitative descriptive study identified factors that impact assigned female at birth (AFAB) cisgender and non-binary sexual minority individuals’ decision to engage, or not engage, in health-seeking behaviors and receive preventative health care services. AFAB sexual minority individuals were asked to describe their health care experiences to determine modifiable factors that could improve their intention to seek care and improve their health care experiences. Purposive sampling was used to recruit AFAB sexual minority individuals between 18 and 30 years of age in the Chicago metropolitan area. Three main themes emerged from data acquired through individual interviews: (1) “ask the right …

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Migrants, Covid-19, And Italy: A Multimodal Critical Discourse Analysis Of The Construction Of And Resistance To Nationalist Discourses, Alessia Barbici Wagner, Theresa Catalano, Bryan Meadows Jan 2023

Migrants, Covid-19, And Italy: A Multimodal Critical Discourse Analysis Of The Construction Of And Resistance To Nationalist Discourses, Alessia Barbici Wagner, Theresa Catalano, Bryan Meadows

Department of Teaching, Learning, and Teacher Education: Faculty Publications

Migration has historically been a controversial issue around the world and one that has often been harnessed by people in power (or people hoping to gain power) for their own political agendas. In times of a global pandemic, the scapegoating of migrants has only increased, often rooted in nationalist ideologies which lead to policies and practices that harm migrants and the larger society. The present paper employs multimodal critical discourse analysis to explore how nationalist ideologies supported by right-wing populism are constructed visually and verbally during COVID-19 on Italian social media in regard to migration. We analyze Giorgia Meloni’s (leader …

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The Effects Of Nausea And Vomiting On Mother And Child, Mayane Bensoussan Jan 2023

The Effects Of Nausea And Vomiting On Mother And Child, Mayane Bensoussan

The Science Journal of the Lander College of Arts and Sciences

Nausea and vomiting are common side effects that can occur during pregnancy. On one hand, it can lead to its severe form called hyperemesis gravidarum, which can lead to hospitalization for electrolyte imbalances, dehydration, muscle weakness, or arrhythmias. On the other hand, nausea and vomiting may be an indication of a statistically healthier fetus. Benefits of maternal nausea and emesis to the developing fetus include improved neural development, decreased risk for congenital heart defects, and decreased incidence of miscarriages. Additionally, benefits to the mother include decreased risk for lung, cervical, and rectal cancer. The mothers also had an overall decreased …

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Development Of A Chitosan Nano-Immersion Vaccine Against Aeromonas Veronii Infection In Red Tilapia (Oreochromis Sp.), Pimwarang Sukkarun Jan 2023

Development Of A Chitosan Nano-Immersion Vaccine Against Aeromonas Veronii Infection In Red Tilapia (Oreochromis Sp.), Pimwarang Sukkarun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Red tilapia (Oreochromis sp.) is a prominent freshwater fish in Thai aquaculture. It has long been afflicted by severe bacterial diseases, ulcerative syndrome, and hemorrhagic septicemia, primarily caused by Aeromonas veronii. Vaccination is a key strategy for control and prevention. In this study a chitosan nano-immersion vaccine has been developed using a nanoemulsion technique and surface modification method with chitosan polymers. The physicochemical properties, mucoadhesive properties, immune response assays, and vaccine efficacy were investigated. The results showed that the vaccine is spherical-shaped, nanometer-sized, and having monodispersed positive charge. The mucoadhesive characterization, observed by SEM and fluorescence microscope imaging, demonstrated that …

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Development Of A Latex Agglutination Test Based On Vh Antibody Fragment For Detection Of Streptococcus Suis Serotype 2, Kiratika Chidkoksung Jan 2023

Development Of A Latex Agglutination Test Based On Vh Antibody Fragment For Detection Of Streptococcus Suis Serotype 2, Kiratika Chidkoksung

Chulalongkorn University Theses and Dissertations (Chula ETD)

Streptococcus suis serotype 2 (S. suis 2) is an important porcine pathogen that causes diseases in both swine and humans. For rapid S. suis 2 identification, a novel latex agglutination test (LAT) based on heavy-chain variable domain antibody (VH) was developed. Firstly, the soluble 47B3 VH antibody fragment from a phage display library, in which cysteine residues were engineered at the C-terminus, was expressed in Escherichia coli. The purified protein was then gently reduced to form monomeric soluble 47B3 VH subsequently used to coat with latex beads by means of site-specific conjugation. The detection sensitivity was found to be as …

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Factors Affecting The Decision Making To Use Thai Traditional Medical Postpartum Care Services Among Pregnant And Postpartum Women In Bangkok, Thailand, Lunlalin Sirichai Jan 2023

Factors Affecting The Decision Making To Use Thai Traditional Medical Postpartum Care Services Among Pregnant And Postpartum Women In Bangkok, Thailand, Lunlalin Sirichai

Chulalongkorn University Theses and Dissertations (Chula ETD)

After giving birth, there will be changes in the body during the postpartum period to return to the normal state as before pregnancy. Postpartum women often have common problems, such as lower back pain, breast engorgement, plugged milk ducts, mastitis, and not having enough breast milk. In Thai traditional medicine, there has been postpartum care for a long time. Thai traditional medicine postpartum care services, also referred to as Yu-Fai, can assist in easing postpartum discomfort. But at present, the number of people receiving postpartum care services with Thai traditional medicine is still low. Therefore, this study aimed to determine …

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Association Between Related Factors And Communication Channels Among Women With Abortion Service At Private Clinics In Thailand, Xiao Wang Jan 2023

Association Between Related Factors And Communication Channels Among Women With Abortion Service At Private Clinics In Thailand, Xiao Wang

Chulalongkorn University Theses and Dissertations (Chula ETD)

In February 2021, abortion was officially permitted in Thailand. In the delivery of abortion services, communication channel is a key factor in assisting clients to access services. Research on clients' choices of communication channels is important for increasing clients' access to legal abortion services. This secondary data cross-sectional study aims to identify the association between factors related to communication channels among the clients who receive abortion services at The Planned Parenthood Association of Thailand (PPAT)’s clinic. The study samples covered 3,734 clients who get abortion service at PPAT’s clinic from February 2021 to December 2022. The researcher employed socio-demographic characteristic, …

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M2 Macrophages In Human Periapical Lesions In Relation To Histopathological Diagnosis, Clinical Features, And Lesion Volume, Supanant Visarnta Jan 2023

M2 Macrophages In Human Periapical Lesions In Relation To Histopathological Diagnosis, Clinical Features, And Lesion Volume, Supanant Visarnta

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study evaluated M1 and M2 macrophage polarization in human periapical cysts and granulomas through an immunohistochemical analysis and investigated the correlation between the macrophage polarization and histopathological diagnosis, clinical features and lesion volume using cone-beam computed tomography. The periapical biopsies histopathologically diagnosed as radicular cyst (n=52) and periapical granuloma (n=51) were analyzed by immunohistochemical method. Immuno-expressions of CD68 and CD163 were quantified. The CD68/CD163 ratio was adopted to represent M1 or M2 macrophage polarization. Pathological diagnosis, patients’ age, gender, clinical signs and symptoms, tooth location of the periapical lesion, and history of root canal treatment were obtained from treatment …

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Equity In Maternal And Child Health In Myanmar: Benefit Incidence Analysis On Utilization Of Health Services, Myint Si Thu Jan 2023

Equity In Maternal And Child Health In Myanmar: Benefit Incidence Analysis On Utilization Of Health Services, Myint Si Thu

Chulalongkorn University Theses and Dissertations (Chula ETD)

Utilization of maternal and child health services plays a crucial role in preventing pregnancy related deaths and child deaths. High levels of maternal and child mortalities are remaining as public health problems in Myanmar. Therefore, this study aims to examine the effects of socio-economic and geographical factors on utilization of maternal and child health services at public health facilities in Myanmar, and analyze the levels of benefit that go to the people in different wealth status. Secondary data analysis is conducted using maternal and child health data from Myanmar Demographic and Health Survey (MDHS) 2015- 16. Marginal effects of multinomial …

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Contamination Of Antimicrobial-Resistant Escherichia Coli, Salmonella Spp., Enterococcus Faecalis, And Enterococcus Faecium In Commercial Raw Meat-Based Diets For Cats And Dogs, Rusmin Indra Jan 2023

Contamination Of Antimicrobial-Resistant Escherichia Coli, Salmonella Spp., Enterococcus Faecalis, And Enterococcus Faecium In Commercial Raw Meat-Based Diets For Cats And Dogs, Rusmin Indra

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to investigate the contamination of third-generation cephalosporin (3GC)-resistant Escherichia coli, Salmonella spp., Enterococcus faecalis, and E. faecium in commercial raw meat-based diets (RMBDs) for cats and dogs in Thailand. Fifty RMBD products from ten brands were included for total plate count and bacterial isolation. Antimicrobial susceptibility testing was conducted for the targeted bacteria. Extended-spectrum β-lactamase (ESBL) production and the presence of blaCTX-M and mcr genes were detected. Additionally, E. coli phylogroups and Salmonella serovars were identified. The RMBD samples were contaminated by 3GC-resistant E. coli (80.0%), Salmonella spp. (70.0%), E. faecalis (100%), and E. faecium (84.0%). All …

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Genome Characterization And Significant Gene Annotation Of Mycobacteria Based On Data From High-Throughput Dna Sequencing Technology, Ajala Prommi Jan 2023

Genome Characterization And Significant Gene Annotation Of Mycobacteria Based On Data From High-Throughput Dna Sequencing Technology, Ajala Prommi

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mycobacteria encompass a variety of species, including pathogenic strains such as Mycobacterium tuberculosis complex (MTBC) and nontuberculous mycobacteria (NTM). These organisms are responsible for significant health challenges globally and in Thailand, particularly due to tuberculosis (TB) and its drug-resistant forms. This dissertation aims to characterize the whole genome of various Mycobacterium species and annotate significant genes utilizing high-throughput DNA sequencing technology. Key objectives include investigating the mutations in Mycobacterium tuberculosis responsible for resistance to primary anti-TB drugs, specifically isoniazid, and analyzing the resistome of Mycobacterium abscessus, a rapidly growing NTM, isolated from patients in Thailand. The study also seeks to …

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Genetic Diversity Of Influenza A Viruses In Live Bird Markets And Free-Grazing Ducks In Thailand, Supanat Boonyapisitsopa Jan 2023

Genetic Diversity Of Influenza A Viruses In Live Bird Markets And Free-Grazing Ducks In Thailand, Supanat Boonyapisitsopa

Chulalongkorn University Theses and Dissertations (Chula ETD)

Influenza A viruses (IAVs) can infect birds and a wide variety of mammals. Live bird markets (LBMs) and free-grazing ducks (FGDs) are the important reservoirs of influenza A viruses in Thailand. This study aims to gain the overall information of IAVs circulated in LBMs in Bangkok and in FGD flocks in Thailand. IAVs surveillance in LBM in Bangkok was conducted to identified the IAVs in LBM during 2019-2020. The IAV-H9N2 (n=8) and IAV-H9Nx (n=2) were isolated from 1,178 swab samples. The IAVs of the previous CU-EIDAs’ LBM surveillance programs during 2014-2018 were included for overall genetic analysis. Total 6 subtypes …

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A Comprehensive Study Of African Horse Sickness Outbreak In The Northeastern Region Of Thailand: Outbreak Investigation, Genetic Characterization, And Longitudinal Serological Monitoring, Napawan Bunpapong Jan 2023

A Comprehensive Study Of African Horse Sickness Outbreak In The Northeastern Region Of Thailand: Outbreak Investigation, Genetic Characterization, And Longitudinal Serological Monitoring, Napawan Bunpapong

Chulalongkorn University Theses and Dissertations (Chula ETD)

African horse sickness (AHS) results from infection with the African horse sickness virus (AHSV). The AHSV is a non-contagious and belongs to genus Orbivirus, family Reoviridae and primarily by Culicoides midges. AHS caused the devastating infection in equine population, including horses, ponies, European donkeys, and mules. AHS maintains its occurrence in southern African countries, it may possess threatening impact to the naïve regions such as Asia or Southeast Asia. The objectives of this study are 1) To investigate the emerging AHS outbreak in the Northeastern region of Thailand, 2) To characterize emerged AHSV in Thailand and 3) To monitor serological …

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Gene Expression Of Soft Tissue Covering Bone Grafted With Xenograft In Human, Atithan Termworasin Jan 2023

Gene Expression Of Soft Tissue Covering Bone Grafted With Xenograft In Human, Atithan Termworasin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Soft tissue is one of many factors that influence the esthetic success of dental implants. This study explores soft tissue reaction between soft tissue covering bone grafted with xenograft and soft tissue in normal healing by analyzing the levels of inflammatory cytokine including TNF-α, IL-6, IL-8 and NF-kB1. Soft tissues are collected after 4 to 6 months of healing and analyzed by reverse transcription quantitative polymerase chain reaction (RT-qPCR). The result shows that the relative gene expression of TNF-α, IL-6, IL-8, and NF-kB1 are not significantly different in soft tissue covering xenograft compared to the ones in soft tissue covering …

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Correlation Of The Malassezia Spp. Prevalence And Inflamed Seborrheic Keratosis, Nirin Seatamanoch Jan 2023

Correlation Of The Malassezia Spp. Prevalence And Inflamed Seborrheic Keratosis, Nirin Seatamanoch

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Seborrheic keratosis (SK) is a common benign skin tumor. Patients often seek medical assistance due to cosmetic concerns and irritation. From pathological examination, yeasts are commonly found in the stratum corneum layer. Malassezia spp. is a commensal fungus on human skin. It is associated with various inflammatory skin diseases. Objectives: This study aimed to determine links between inflammation in SK and Malassezia spp. presence as well as other different features of SK pathological findings that may be associated with inflammation. Materials and Methods: Two hundred sixty-one hematoxylin and eosin histology SK slides were recruited in our study. Patients with …

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การเปลี่ยนแปลงของไขมันในเลือดหลังจากเปลี่ยนเป็นสูตรยาที่มียาโดลูเทกราเวียร์เป็นยาหลักแทน ยายับยั้งเอนไซม์โปรติเอสในผู้ป่วยเอชไอวีที่ใช้ยาต้านไวรัสเอชไอวีสูตรที่สอง, ณัฐพล เกียรติกังวานชน Jan 2023

การเปลี่ยนแปลงของไขมันในเลือดหลังจากเปลี่ยนเป็นสูตรยาที่มียาโดลูเทกราเวียร์เป็นยาหลักแทน ยายับยั้งเอนไซม์โปรติเอสในผู้ป่วยเอชไอวีที่ใช้ยาต้านไวรัสเอชไอวีสูตรที่สอง, ณัฐพล เกียรติกังวานชน

Chulalongkorn University Theses and Dissertations (Chula ETD)

ที่มาและความสำคัญ: การรักษาผู้ป่วยเอชไอวีด้วยยาต้านไวรัสเอชไอวีด้วยยายับยั้งเอนไซม์โปรติเอสมีประสิทธิภาพในการกดปริมาณเชื้อไวรัสได้ดี แต่ก็ส่งผลให้เกิดการเปลี่ยนแปลงของระบบการเผาพลาญในร่างกาย เช่น ความผิดปกติของระดับไขมันในเลือดและความเสี่ยงต่อโรคหัวใจและหลอดเลือดที่เพิ่มขึ้น การเปลี่ยนยาต้านไวรัสไปเป็นสูตรยาโดลูเทกราเวียร์เป็นยาหลัก อาจช่วยให้ลดปัญหาดังกล่าวได้ งานวิจัยนี้มีวัตถุประสงค์เพื่อศึกษาการเปลี่ยนแปลงระดับไขมันในเลือด ซึ่งเป็นปัจจัยเสี่ยงต่อโรคหัวใจและหลอดเลือด วิธีการวิจัย: ทำการวิจัยแบบเก็บข้อมูลไปข้างหน้าในผู้ป่วยเอชไอวีที่ใช้ยาต้านไวรัสเอชไอวีสูตรที่สองเป็นยายับยั้งเอนไซม์โปรติเอส เพื่อประเมินระดับไขมันในเลือด และระบบการเผาพลาญในร่างกายอื่นๆ หลังจากเปลี่ยนเป็นยาโดลูเทกราเวียร์เป็นยาหลักแทน เป็นเวลา 48 สัปดาห์ ผลการศึกษา: มีผู้เข้าร่วมวิจัย 144 ราย การเปลี่ยนไปใช้ยาโดลูเทกราเวียร์เป็นยาหลักแทนยายับยั้งเอนไซม์โปรติเอสที่ 48 สัปดาห์ ทำให้ระดับไขมันชนิดไตรกลีเซอไรด์ลดลง และไขมันชนิดความหนาแน่นสูงเพิ่มขึ้น อย่างมีนัยสำคัญทางสถิติ (p < 0.001, p = 0.004 ตามลำดับ) ในขณะที่ไขมันชนิดความหนาแน่นต่ำและคอเลสเตอรอลยังคงที่ และพบว่าทำให้ดัชนีมวลกายเพิ่มขึ้นอย่างมีนัยสำคัญทางสถิติ (p < 0.001) อย่างไรก็ตามยังมีประสิทธิภาพในการกดไวรัสได้ดีไม่แตกต่างกัน สรุปผล: การเปลี่ยนไปใช้สูตรยาโดลูเทกราเวียร์เป็นยาหลักในผู้ป่วยเอชไอวีทำให้ไขมันในเลือดของผู้ป่วยเปลี่ยนแปลงไปในทิศทางที่ดีขึ้นจากขณะที่ใช้ยายับยั้งเอนไซม์โปรติเอส และสามารถลดความซับซ้อนจากรักษาเอชไอวีได้เป็นอย่างดี

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ปัจจัยเสี่ยงของการเกิดโรคข้ออักเสบติดเชื้อซัลโมเนลลาเมื่อเปรียบเทียบกับเชื้อแบคทีเรียอื่น: การศึกษาแบบเก็บข้อมูลย้อนหลัง, กรัณย์ ประสพสันติ Jan 2023

ปัจจัยเสี่ยงของการเกิดโรคข้ออักเสบติดเชื้อซัลโมเนลลาเมื่อเปรียบเทียบกับเชื้อแบคทีเรียอื่น: การศึกษาแบบเก็บข้อมูลย้อนหลัง, กรัณย์ ประสพสันติ

Chulalongkorn University Theses and Dissertations (Chula ETD)

ที่มาและปัญหาของงานวิจัย โรคข้ออักเสบติดเชื้อซัลโมเนลลาพบได้บ่อยในประชากรที่มีความผิดปกติของระบบภูมิคุ้มกัน การศึกษานี้เป็นการศึกษาแรกที่เปรียบเทียบปัจจัยเสี่ยง อาการและอาการแสดง ผลตรวจทางห้องปฏิบัติการ และแนวทางการรักษาโรคข้ออักเสบติดเชื้อซัลโมเนลลาเมื่อเปรียบเทียบกับข้ออักเสบติดเชื้อแบคทีเรียอื่น ระเบียบวิธีการวิจัย ศึกษาแบบเก็บข้อมูลย้อนหลังในผู้ป่วยโรคข้ออักเสบติดเชื้อแบคทีเรียในโรงพยาบาลจุฬาลงกรณ์ตั้งแต่ 1 มกราคม พ.ศ.2556 ถึง 31 ธันวาคม พ.ศ.2565 แบ่งเป็นกลุ่มข้ออักเสบติดเชื้อซัลโมเนลลา 30 ราย และกลุ่มข้ออักเสบติดเชื้อแบคทีเรียอื่น 120 ราย เพื่อเปรียบเทียบปัจจัยเสี่ยงและข้อมูลอื่น ๆ ข้างต้นระหว่างทั้งสองกลุ่ม ผลการศึกษา ผู้ป่วยโรคข้ออักเสบติดเชื้อซัลโมเนลลามีอายุที่น้อยกว่า (ค่ามัธยฐานคือ 54 ปีและ 63 ปีตามลำดับ; p<0.001) การติดเชื้อซัลโมเนลลา พบมากที่สุดที่ข้อสะโพก ร้อยละ 36.67 แตกต่างจากเชื้อแบคทีเรียอื่นซึ่งพบเพียงร้อยละ 7.50 (p<0.001) สรุป โรคข้ออักเสบติดเชื้อซัลโมเนลลาเมื่อเทียบกับเชื้อแบคทีเรียอื่นมีปัจจัยเสี่ยงคืออายุน้อยและการใช้ยาคอติโคสเตียรอยด์มีระยะเวลาก่อนมาโรงพยาบาลที่นานกว่าและข้ออักเสบที่พบบ่อยคือข้อสะโพก

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Molecular Survey Of Enterocytozoon Bieneusi In Bat Feces Collected From Various Areas Of Thailand, Chatuthanai Savigamin Jan 2023

Molecular Survey Of Enterocytozoon Bieneusi In Bat Feces Collected From Various Areas Of Thailand, Chatuthanai Savigamin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Enterocytozoon bieneusi is a microsporidian pathogen that can cause gastrointestinal diseases such as chronic diarrhea, abdominal pain, and nausea in humans, particularly in immunocompromised individuals. This pathogen has been found in the feces of various animals, from wildlife to domestic animals, but there have been no reports of its detection in bats in Thailand. Given that bat feces are widely used as fertilizers in agriculture and that bat-infested caves are tourist destinations where people may encounter bat feces, there is a need to study the presence of Enterocytozoon bieneusi in bat feces in these areas. In this study, 16 out …

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