Digital Commons Network^™

Assessing The Relationship Between Binding Kinetics And Subcellular Protection Of Ribosomes By Single-Domain Antibodies, Mara Bureau

Legacy Theses & Dissertations (2009 - 2024)

Assessing the ability of VHHs to protect ribosomes from the depurination activity of Ricin toxin’s(RT) enzymatic subunit, RTA, can provide insights regarding binding placement, epitopes of interest and role of affinity in neutralization is critical for the development of anti-toxin countermeasures. Determining the level of correlation between binding strength, binding location and elicited protection can be useful for future and ongoing research. Ricin is easily manufactured and considered one of the most toxic biological agents known. Without an approved vaccine, continued research to design and optimize therapeutic countermeasures is essential. Over the past decade single-domain antibodies (VHHs) have been recognized …

Maternal Exposure Of Perfluoroalkyl Substances (Pfas) During Pregnancy And Wheeze In Children : The Upstate Kids Study, Faria Sharmin

Legacy Theses & Dissertations (2009 - 2024)

Background: Prenatal exposure to perfluoroalkyl substances (PFASs), a group of persistent environmental chemicals with endocrine disrupting abilities, has been associated with immunomodulation and may contribute to the etiology of asthma in young children. The need for research and additional prospective analysis clearly exists to measure the impact of the chemicals (PFAS) on child wheeze or asthma. We used newborn dried blood spots to quantify two PFAS and their associations with infant wheeze in the Upstate KIDS population.Methods: We measured, perfluoro octane - sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in 2071 singleton and 1040 twin infants born to mothers in …

The Identification Of New Directions For The Research Of Adhd, Andrew Burkhardt

Legacy Theses & Dissertations (2009 - 2024)

ADHD is a disease commonly associated with childhood; however, recently adult cases of ADHD have been on the rise. The cause of ADHD is not yet known but can be treated. The issue with the treatment of ADHD is the use of heavily restricted stimulants. The use of these medications carry many health risks, most notability addiction. ADHD also has many co-morbidities like anxiety and autism. This makes ADHD a complex disorder, making the identification of a cause difficult. However, by identifying how drugs used to treat ADHD work, combined with genetic testing, areas of interest start to appear. An …

Examining The Association Between Childhood Adversity And Later Life Cardiometabolic Diseases, Shreya Shrinivas

Legacy Theses & Dissertations (2009 - 2024)

ACEs stands for Adverse Childhood Experiences, which are traumatic or stressful events that occur in childhood before the age of 18 (Wisner, 2022). These experiences can include physical, emotional, or sexual abuse; neglect; household dysfunction, such as parental separation, domestic violence, substance abuse, or incarceration; or exposure to community violence, racism, or discrimination. Research has shown that individuals who experience ACEs are at a higher risk for developing chronic diseases such as heart disease, diabetes, cancer, and mental health disorders later in life (Felitti, 2002). This is because ACEs can cause toxic stress, which is chronic activation of the stress …

Immune System Dysfunction To Toxicant Exposure: An Examination Of Mismatch Theory With Polychlorinated Biphenyls (Pcbs) And Dichlorodiphenyltrichloroethane (P,P'-Ddt), Florence Lee

Legacy Theses & Dissertations (2009 - 2024)

Exposure to environmental contaminants, including persistent organic pollutants (POPs) can disrupt normal immune function. As POPs, polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethane (p,p’-DDE, a metabolite of p,p’-DDT), and hexachlorobenzene (HCB) are synthetic chemicals with long half-lives and can bioaccumulate and biomagnify within organisms throughout the food chain. This dissertation proposes that pollutant exposure can affect the immune system based on a sample of Native American women, thereby influencing human biological variation, and the development of an autoimmune phenotype. Data was collected from a sample of Native American women utilizing anthropometric measurements, medical diagnoses of autoimmune disease, autoimmune dysfunction symptoms, and serum samples. …

Antibody Profiling Of An Elderly Cohort After Sars-Cov-2 Vaccination And Infection Using Dried Blood Spots, Gianna Mirabile

Legacy Theses & Dissertations (2009 - 2024)

Three years after the emergence of SARS-CoV-2 in Wuhan, China, COVID-19 remains a major public health emergency throughout the globe. Although major advancements have been made in terms of controlling the virus, such as the use of mRNA vaccines, SARS-CoV-2 infections from variants of concern (VoC) continue to persist and cause significant morbidity and mortality in vulnerable populations, including the elderly. The ability for public health entities to effectively gauge disease susceptibility across large swaths of the population is critical in deciding when to implement new vaccination recommendations. Dried blood spots (DBS) are an upcoming serological sample type being studied …

Refugia From White-Nose Syndrome: Ecology And Behavior Of Northern Myotis Coastal Populations, Samantha Hoff

Legacy Theses & Dissertations (2009 - 2024)

Recent increases in anthropogenic environmental change have been directly linked to the global loss of biodiversity and are a primary driver of disease emergence in wildlife populations. Infectious diseases interact with other threats to cause population declines and changes in community composition, potentially resulting in local or global extinctions. Yet, outcomes are variable across the landscape, leading some host populations to persist at low numbers. One of the biggest challenges in conserving species threatened by disease is determining whether persisting populations can remain viable into the future once they have been driven to low abundance. White-nose syndrome (WNS) is one …

College Athletes Rolling Up Their Sleeves: Is A Mandatory Covid Vaccine Policy Constitutional?, Clara C. Sporrer

Marquette Sports Law Review

No abstract provided.

Hoarding Lifesaving Knowledge While Millions Die: The Political Economy Of Global Covid-19 Vaccine Apartheid, Kenneth Stancil

Theses and Dissertations--Geography

Coronavirus vaccines saved millions of lives, but experts estimate that the suboptimal production and inequitable distribution of shots resulted in nearly 3 million preventable Covid-19 deaths in 2021 and 2022 as well as millions of indirect deaths during the pandemic. These avoidable fatalities are inseparable from the grotesquely unequal vaccination rates between rich and poor nations. Dose hoarding by high-income countries contributed to vaccine inequality, but the “vaccine apartheid” inflicted on low-income countries reflects an even more fundamental injustice: knowledge hoarding by profit-maximizing pharmaceutical corporations—aided and abetted by wealthy governments—which deprived generic manufacturers of the right to produce additional lifesaving …

Middle School Teacher Perceptions Of The Impact Of The Covid-19 Pandemic, Sherria La Vonne Grubbs

Doctor of Education Dissertations

This paper examines the perceptions of middle school teachers on the impact of the Covid-19 pandemic on student achievement, attendance and enrollment, mental health, and social and economic factors. Allowing the voices of the middle school teachers to be heard was important to this study because it helped to identify some key themes of the impact of the Covid-19 pandemic on education. For this qualitative research study, a survey was created with Google Forms and a focus group discussion was implemented using the zoom platform to gather and collect data for this study. 67 middle school teachers were invited to …

Pharmacological Management Of Oral Lesions, Tanishka Taori, Bhinika Wadher, Shefali Maheshwari, Swapnil Mohod, Suwarna Dangore

International Arab Journal of Dentistry

Oral ulcerations caused by aphtous lesions, leukoplakia, scarlet fever, syphilis, NOMA, mucormycosis herpetic lesions, candidiasis, discoid lupus erythematous, ulcerative lichen planus, mucous membrane pemphigoid, spongy nevus, oral submoucs fibrosis and pemphigus vulgaris are treated in a step-up fashion that may include topical, intralesional, and systemic pharmaceutical treatment. This page discusses the most often used therapy agents, methods, and dosages. Although the emphasis is on local pharmacologic therapy, systemic illnesses that frequently occur with such oral lesions are briefly discussed, as is the appropriate care.

C-Reactive Protein Level And Lipid Profile Among Sars-Cov-2 Recovered Patients In Baghdad / Iraq, Madha Mohammed Sheet Saleh, Abdulrazzak Jabbar Al-Shawi

Al-Nisour Journal for Medical Sciences

Serum markers in post-discharged SARS-CoV-2 patients and their relationship with disease severity among recovered patients are poorly described and, in many occasions, might be related to residual effects of the disease. To evaluate the C-reactive protein positivity and the lipid profile after 2-7 months of recovery in SARS-CoV-2 patients. The study also pointed out the frequency of clinical manifestations during the illness course. A total of 27 COVID-19 recovered patients (13 males and 14 females) with an age range of 21-40 year (mean 27.2) were participated in this study. Variable frequency of symptoms as high as fatigue (96.3%), neurological symptoms …

Co-Infection Of Covid -19 Patient With A. Baumnnii In Iraqi Patients, Maha E. Zidan, Hiba M. Nasir, Jaleel Samanje

Al-Nisour Journal for Medical Sciences

Acinetobacters.baumannii is an opportunistics pathogenshave a highs incidences through immunocompromised individuals, especially those who have experienced elongated hospital stay. To investigate the prevalence of antibiotics resistance genes of A. baumannii in Iraqi Covid -19 patients. Fifty clinical isolats of out of (86) isolate of A. baumannii were isolated patients attacked with Covid19 from different clinical sources and from different hopsitals. All the clinical samples primarily were cultured on Blood, MacConkey agar. For differentiation A. baumannii, the clinical samples were also streaked on Drigalski Lactose agar medium. Suspected colonies were confirmed by VITEK-2 system. Co infected A. baumannii sample with Covid …

Correlation Of Some Biomarker With Severity Of Infection In Covid19 Patients, Qais Hamid Jassim Nasir, Israa Saeed Abbas, Ahmed Ghazi Al-Qaisi

Al-Nisour Journal for Medical Sciences

104 patients. The participants were made up of 30 controls, patients with COVID-19 are, 37 severe patients, and 37 moderate patients (47 males and 57 females) with age range from (30 to 85) years, who were attending in Healing Specialist Center for Crisis in Medical City and Hospital Ibn AlKhatib. during the period from November 2021 to April 2022. in the study patients were divided into three groups based on the severity of their lung involvement as determined by their pulmonary computed tomography scores: severe, moderate, and control. The results showed that no significant Different between R1 and R2 with …

Pregnancy Risk And Coerced Interventions After Dobbs, Elizabeth Kukura

SMU Law Review

Only nine months after the Supreme Court eliminated the federal constitutional right to abortion in Dobbs v. Jackson Women’s Health Organization, fourteen states had banned abortion entirely, and experts estimate the ultimate number of states imposing complete or near-complete restrictions on abortion care will likely rise to twenty-four. Millions of people with the capacity for pregnancy now (or will soon) live in places where getting pregnant means there is no choice other than to carry the pregnancy to term and give birth. One underappreciated, though critically important, impact of Dobbs is the extent to which newly enacted abortion restrictions will …

A Type-2 Fuzzy Rule-Based Model For Diagnosis Of Covid-19, İhsan Şahi̇n, Erhan Akdoğan, Mehmet Emi̇n Aktan

Turkish Journal of Electrical Engineering and Computer Sciences

In this study, a type-2 fuzzy logic-based decision support system comprising clinical examination and blood test results that health professionals can use in addition to existing methods in the diagnosis of COVID-19 has been developed. The developed system consists of three fuzzy units. The first fuzzy unit produces COVID-19 positivity as a percentage according to the respiratory rate, loss of smell, and body temperature values, and the second fuzzy unit according to the C-reactive protein, lymphocyte, and D-dimer values obtained as a result of the blood tests. In the third fuzzy unit, the COVID-19 positivity risks according to the clinical …

Influencing Factors On Chinese Tourists’ Health Behavior Prevention Toward Post Covid-19 In Beijing, China, Sihang Li

Chulalongkorn University Theses and Dissertations (Chula ETD)

The global travel and tourism landscape has been profoundly impacted by the COVID-19 pandemic, requiring precautionary measures to keep travelers and local communities safe. In this context, it is of great significance to understand the factors that influence the adoption of healthy behavioral prevention among Chinese tourists. This study delves into the complex connections between risk perceptions, knowledge, attitudes, social norms, accessibility, communication, and cultural factors that influence mask-wearing behavior among tourists in China post-COVID-19. This study aims to identify the prevalence of preventive health behaviors among Chinese tourists during post-COVID-19 and investigate the association between influencing factors and tourists’ …

Presumptive Hepatogenous Photosensitization In Beef Cattle Winter Grazing A Cover Crop Containing Brassica Spp. Turnips, Matthew M. Hille, Scott A. Fritz, Breanna C. Brown

School of Veterinary and Biomedical Sciences: Faculty Publications

Over a period of ~2 wk, 5 adult beef cows developed severe necrotizing skin lesions on the face and neck shortly after being moved to a field with a cover crop of Brassica spp. turnips. We describe here the clinical signs, hematology, and serum chemistry results, as well as gross and histopathologic findings, from this outbreak. We made a presumptive diagnosis of Brassica-associated liver disease (BALD) based on the similarities in the history and diagnostic findings observed with previously reported cases of BALD from elsewhere in the world. BALD has not been reported previously in cattle in North America, …

Reconsidering The Good Of Improving Accountability, Roy L. Heidelberg

Faculty Publications

Among the rhetorical pleas that follow most instances of public dissatisfaction is the call for more or better accountability. Accountability is a lauded notion, a “golden concept” that is considered widely as critical to the success of democratic government. Such pleas, I will argue, are misplaced. Rather than starting from the premise of accountability as an idea that no one can be against, I consider the possibility that accountability undermines the very notion it ostensibly promotes: self-government. The concept of accountability in modern political theory is tied more closely to the emergence of an impersonal administrative state than it is …

Valuing Medical Innovation, Daniel J. Hemel, Lisa Larrimore Ouellette

Faculty Articles

Scholars and policymakers across the ideological spectrum agree that the U.S. drug pricing system is deeply flawed. Most reform proposals focus on one symptom: high prices for existing drugs. But high prices aren’t all that ails the U.S. drug pricing system: Current law also provides weak incentives for medical innovation across wide areas, including vaccines, antibiotics, cancer preventives and early-stage cancer treatments, and cardiovascular drugs. Impediments to pharmaceutical innovation not only slow the growth of U.S. life expectancy but also exacerbate racial disparities in health outcomes. High drug prices and slow pharmaceutical progress are two facets of the same problem: …

Public Health Interventions Guided By Houston’S Wastewater Surveillance Program During The Covid-19 Pandemic, Loren Hopkins, Katherine B Ensor, Lauren Stadler, Catherine D Johnson, Rebecca Schneider, Kaavya Domakonda, James J Mccarthy, Edward J Septimus, David Persse, Stephen L Williams

Faculty, Staff and Student Publications

Since the start of the COVID-19 pandemic, wastewater surveillance has emerged as a powerful tool used by public health authorities to track SARS-CoV-2 infections in communities. In May 2020, the Houston Health Department began working with a coalition of municipal and academic partners to develop a wastewater monitoring and reporting system for the city of Houston, Texas. Data collected from the system are integrated with other COVID-19 surveillance data and communicated through different channels to local authorities and the general public. This information is used to shape policies and inform actions to mitigate and prevent the spread of COVID-19 at …

Taxonomic Classification Of Viral And Bacterial Dna Following 2021 Avian Mass Mortality Event, Tessa Baillargeon

Honors Theses and Capstones

From May through July 2021, an unusual mortality event occurred along the eastern coast and Midwest of the United States. Thousands of birds, mostly from the order Passeriformes, were part of the die-off including blue jays (Cyanocitta cristata), common grackles (Quiscalus quiscula), European starlings (Sturnus vulgaris), American robins (Turdus migratorius). Clinical signs included crusted eyes, swollen conjunctiva, otitis, seizures, and ataxia.

The New Hampshire Veterinary Diagnostic Laboratory (NHVDL) received over 100 affected birds from various collaborators throughout the United States including Washington DC, NJ, CT, MD, and OH. Given the timing and geologic …

Investigating The Role Of Bromodomain Proteins On Histone Post-Translational Modifications In Toxoplasma Gondii, Joshua Steven Berthiaume

Honors Theses and Capstones

Toxoplasma gondii is a prevalent pathogenic parasite that infects approximately 25 percent of the US population. For the parasite to successfully establish and maintain infection in its host, properly controlled regulation of gene expression is critical. One way Toxoplasma regulates gene expression is through modification of histone proteins that bind to DNA and can control gene accessibility. Acetylation is a modification that is added to histones that changes chromatin structure to enhance gene activation. Histone acetylation can also regulate gene expression by recruitment of important regulators such as bromodomain proteins (BDP). A previous study showed that loss of the bromodomain …

Perspectives On The Use Of Molecular Hiv Data For Public Health, Margaret Watson

College of Graduate Studies: Theses & Dissertations

Background. Effective HIV treatment and pre-exposure prophylaxis can drastically reduce the risk of acquiring HIV and prevent most future transmission, but these advances are not accessible to many who could most benefit from them. Advances in use of molecular sequence data to inform prevention efforts, paired with supportive interventions, have the potential to identify clusters of rapid HIV transmission and focus prevention resources toward areas of highest need. Although molecular cluster detection has been successfully used in other areas of public health, advocates for people with HIV have raised concerns about the application of this approach because of HIV …

Risk Factors Of Human Papillomavirus Positive Oropharyngeal Cancer In Men, Kentress Davison

Walden Dissertations and Doctoral Studies

The human papillomavirus (HPV) is a leading domestic and global sexually transmitted disease. The purpose of this secondary quantitative, cross-sectional study is to investigate if there is an relationship between the rate of oral HPV-oropharyngeal squamous cell carcinoma (OPSCC) and race, exposure to smoking cigarettes (tobacco), risky sexual behavior, and participation in oral sex of male-to-male contact vs. male-to-female contact. The social cognitive theory grounded this study. The University of Alabama at Birmingham cancer database population supplied the study’s sample size of 337 males greater than 18 years of age with a diagnosis of OPSCC. I conducted descriptive analyses using …

Association Of Income, Education, Employment And Covid-19 Mortality In Brazil, Marcelina Machado

Walden Dissertations and Doctoral Studies

The increased mortality rates from COVID-19 in Brazil have adversely affectedvulnerable populations and placed a severe burden on its public health system as compared to other nations. Focusing on socioeconomic status as a risk factor in this retrospective cohort study, I investigated the association between Brazilian COVID-19 mortality rate, income, school enrollment rate, and employment rate after controlling for the demographics and immunization rate. This is an important issue as an increase in incidence and mortality rates affects how governmental and public health leaders can effectively control and prevent disease spread. Using the fundamental causes of disease theory as the …

Age, Race/Hispanic Origin, And Covid-19 Mortality Among Sickle Cell Disease Patients In The United States, Joe Lamont Ndula

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic remains a global health challenge, with 6.7 million deaths worldwide as of January 2023. It has illuminated the health iniquities in underserved communities and populations like those with sickle cell disease (SCD). Researchers have associated the COVID-19 outcome among SCD patients in other regions of the globe. The purpose of this retrospective cross-sectional observational study was to investigate the relationship between age, race/Hispanic origin, and COVID-19 mortality among persons with SCD in the United States from January 2020 to March 2021. The Krieger ecosocial theory of disease distribution framed the study. Data were drawn from an existing …

The Hidden Judicial Springs Of U.S. Foreign Policy, Mariano-Florentino Cuéllar, Aziz Z. Huq

Public Law and Legal Theory Working Papers

No abstract provided.

Norovirus Outbreaks In A Pediatric Hospital: Lessons Learned, Idaresit Umoh, Bethany Phillips, Michael Sebert

2023

No abstract provided.

Adolescent, Caregiver And Provider Perspectives On Tuberculosis Treatment Adherence: A Qualitative Study From Lima, Peru, Silvia S. Chiang, Liz Senador, Elmer Altamirano, Milagros Wong, Catherine B. Beckhorn, Stephanie Roche, Julia Coit, Victoria Elena Rapoport, Leonid Lecca, Jerome T. Galea

Social Work Faculty Publications

Objectives: To understand the perspectives of adolescents (10–19 years old), their caregivers and healthcare providers regarding factors that impact adherence to tuberculosis (TB) treatment among adolescents.

Design: We conducted in-depth interviews using semistructured interview guides based on the World Health Organization (WHO)’s Five Dimensions of Adherence framework, which conceptualises adherence as being related to the health system, socioeconomic factors, patient, treatment and condition. We applied framework thematic analysis.

Setting: Between August 2018 and May 2019, at 32 public health centres operated by the Ministry of Health in Lima, Peru.

Participants: We interviewed 34 adolescents who completed or were lost to …