Digital Commons Network^™

Human Genetic Engineering: Should Indonesia Regulate It?, Hari Sutra Disemadi

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Human genetic engineering raises pros and cons. Despite the potential to contribute to the health sector, it can cause several problems. While, in theory, it goes against nature and against other conservative beliefs, human genetic engineering gains important support from Transhumanism—a philosophy promoting the scientific evolution of the human race. This study determines the relevancy regulation of human genetic engineering on a global scope and how it affects the prospects of regulating human genetic engineering in Indonesia. The study aims to provide consideration for Indonesia in determining the legality status of human genetic engineering, through analyses of legal constructions surrounding …

Non-Invasive Real-Time Pulsed Doppler Assessment Of Blood Flow In Mouse Ophthalmic Artery, Iraida Sharina, Radwa Awad, Soren Cobb, Emil Martin, Sean P Marrelli, Anilkumar K Reddy

Faculty, Staff and Student Publications

Non-invasive and high-temporal resolution methods for characterizing blood flow in mouse cranial arteries, such as the ophthalmic artery (OphA), are lacking. We present an application of pulsed Doppler ultrasound to provide real-time, non-invasive measurement of blood flow velocity in the OphA through an identified soft tissue window in the mouse head. We confirmed the identity of the artery and mapped its origin from the internal carotid artery by a combination of microcomputed tomography (microCT) vascular imaging and transient occlusion of the internal carotid artery. Application of our approach demonstrated sex differences in the OphA vasodilative response to agonists. We also …

Learn By Doing: A Flipped Classroom Approach To Teaching Exercise Testing And Prescription, Zakkoyya H. Lewis

Educational Practices in Kinesiology

The purpose of this paper is to describe a case-study based flipped classroom approach for teaching exercise testing and prescription. The goal of this approach is to provide students with supervised “real world” experience while also exposing students to diverse populations (e.g. health, age, culture, employment, ability). Students will complete a client interview, conduct a complete fitness assessment included a graded exercise test, and develop an individualized exercise prescription. The flipped classroom is intended to be incorporated into an in-person advanced level course, ideally less than 20 students per section. Completion of an introductory level exercise testing and prescription course …

Minutes, Curriculum Committee Meeting, Tuesday, February 18, 2025, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.

Sustainability Considerations For End-Of-Life Fibre-Reinforced Plastic Boats, Ruadan Geraghty, Jasper Graham-Jones, Richard Pemberton, John Summerscales, Simon Bray

School of Engineering, Computing and Mathematics

In the 1950s, glass fibre-reinforced polyester resin (GRP, also known as fibreglass or glassfibre) composites replaced wood and metal as the material for small recreational and work boats. The changes resulted from relative ease of manufacture, durability, and low maintenance. New fibres and resins then became available to create a wider range of Fibre-Reinforced Plastics (FRP). Vessels remain serviceable beyond design life: 10 years for inflatables, 20 years for motorboats and 30 years plus for sailboats. Many vessels have now reached end-of-life (EoL) and become Abandoned or Derelict Vessels (ADV). Given that thermosetting resin is not easy to recycle, these …

Vertex-Based Analysis Of Cerebral Blood Flow And Fractional Amplitude Of Low-Frequency Fluctuations (Cbf-Falff) Coupling In Moderate-To-Severe Traumatic Brain Injury During The First Year Post-Injury, Vaidehi Hemkumar Patel

Dissertations, Theses, and Capstone Projects

Traumatic brain injury (TBI) is known to involve damage in the neurovascular unit. TBI may disrupt the brain’s neurovascular coupling–the relationship between cerebral blood flow and neural activity–that can lead to cognitive and functional impairments. This study attempted to non-invasively investigate neurovascular coupling in patients with moderate to severe TBI (msTBI) during the first year post-injury using a combined metric of cerebral blood flow (CBF) and fractional amplitude of low-frequency fluctuations (fALFF), a proxy for spontaneous neural activity. Using arterial spin labeling (ASL) and functional MRI sequences, CBF and fALFF were measured in 29 msTBI patients 3-, 6- and 12-months …

Endogenous And Fluorescent Sterols Reveal The Molecular Basis For Ligand Selectivity Of Human Sterol Transporters, Laura Depta, Hogan P Bryce-Rogers, Nienke J Dekker, Anna Wiehl Bønke, Nicolò Camporese, Mingxing Qian, Yuanjian Xu, Douglas F Covey, Luca Laraia

2020-Current year OA Pubs

Sterol transport proteins (STPs) play a pivotal role in cholesterol homeostasis and therefore are essential for healthy human physiology. Despite recent advances in dissecting functions of STPs in the human cell, there is still a significant knowledge gap regarding their specific biological functions and a lack of suitable selective probes for their study. Here, we profile fluorescent steroid-based probes across ten STPs, uncovering substantial differences in their selectivity, aiding the retrospective and prospective interpretation of biological results generated with those probes. These results guided the establishment of an STP screening panel combining diverse biophysical assays, enabling the evaluation of 42 …

The Impact Of Using A Step-Counting Wristband On Promoting Physical Activity Before And During The Blessed Month Of Ramadan, Saleh M. Hammad, Sief Addeen Saqr

An-Najah University Journal for Research - B (Humanities)

Objectives: This study aimed to investigate the impact of using a step-counting wristband on motivating physical activity before and during the holy month of Ramadan. Methods: The researchers used the experimental method in its quasi-experimental form due to its suitability for the nature and objectives of the study. The International Physical Activity Questionnaire (IPAQ) was used to collect study data, along with the health app from Apple to calculate step counts over the six months preceding the study and during the application period. Additionally, a dummy technological wristband was utilized, explained to the sample participants as functioning to count steps …

Heartdj - Music Recommendation And Generation Through Biofeedback From Heart Rate Variability, Egemen Şahin

Dartmouth College Master’s Theses

This study investigates the integration of real-time physiological data with AI-generated music to enhance emotional well-being, stress regulation, and focus, using Heart Rate Variability (HRV) as a biomarker of autonomic function. Conducted in two phases—Stable Audio Open (SAO) and Suno (SUNO)—the research evaluates biofeedback-driven music interventions across varying daily music-listening habits.

In the SAO phase, short AI-generated instrumental tracks were compared with Spotify recommendations and guided meditation. Modest HRV improvements were observed in biofeedback conditions, but participants noted emotional limitations, citing short track lengths and abrupt transitions.

The SUNO phase addressed these limitations with longer, more complex AI-generated compositions combined …

Comparing 17Β-Estradiol And Progesterone Concentrations In Young, Physically Active Females: Insights From Plasma Versus Serum Analysis, Samantha N. Rowland, Mariasole Da Boit, Rachel Tan, Liam M. Heaney, Stephen J. Bailey

All Faculty Open Access Publications

Serum measurements of 17β-estradiol and progesterone are widely used to verify menstrual cycle status and confirm contraceptive use, often through commercially available immunoassay kits. However, no studies have investigated whether blood collection tube chemistries influence hormone concentrations in young females, despite assays permitting the use of different biofluids with similar reference ranges. In this study, venous blood was sampled from physically active females (n = 25) using Ethylenediaminetetraacetic acid (EDTA) and serum vacutainers, and 17β-estradiol and progesterone concentrations were measured using competitive immunoenzymatic assays. Median plasma concentrations of 17β-estradiol and progesterone were 44.2% (plasma 40.75 vs. serum 28.25 pg/ml) and …

Exploring The Role Of Cyclin D1 In Regulating Thermogenic Program In Brown Adipose Tissue, Chengrui Qiu

Biomedical Sciences ETDs

Abstract Adipose tissue plays a multifaceted role in regulating metabolic health and contributing to the pathophysiology of various diseases. Brown Adipose Tissue (BAT), a vital organ that senses different environmental cues such as cold stress and diet and then undergoes non-shivering thermogenesis in mammalian animals, enhancing energy expenditure to combat obesity. In our recent published study, we found that the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway exhibits doubleedge effects in regulating thermogenic function, with opposite role in BAT and white adipose tissue (WAT). To further investigate the molecular mechanisms underlying the dual role of mTORC1 in thermogenic …

Minerals And Human Health: From Deficiency To Toxicity, Mohammed S. Razzaque, Sunil J. Wimalawansa

School of Medicine Publications

Minerals are essential nutrients that play critical roles in human health by regulating various physiological functions. Examples include bone development, enzyme function, nerve signaling, and the immune response. Both the deficiencies and toxicities of minerals can have significant health implications. Deficiencies in macrominerals such as calcium, magnesium, and phosphate can lead to osteoporosis (associated with falls and fractures), cardiovascular events, and neuromuscular dysfunction. Trace mineral deficiencies, such as iron and zinc. Selenium deficiency impairs oxygen transport, immune function, and antioxidant defenses, contributing to anemia, delaying wound healing, and increasing susceptibility to infectious diseases. Conversely, excessive intake of minerals can have …

The Architecture Of Disability: Buildings, Cities, And Landscapes Beyond Access [Book Review], Shannon Marie Robinson

Disability in LIS (DisLIS)

This isn’t another critique of accessibility standards in design. Rather, Gissen revolutionizes approaches to architecture, public landscape, and urban planning by centering impairment, allowing for a radical interpretation of the historical built environment, and thereby provides a more inclusive approach to its future.

How Did Covid-19 Impact Physiology Research Globally? – Lessons Learned And Future Recommendations, Jeet Patel, Santanu De

Mako: NSU Undergraduate Student Journal

The Coronavirus Infectious Disease 2019 (COVID-19) pandemic caused massive changes in the medical field across the globe. As the whole world moved from in-person to remote activities, students found themselves in a predicament where they were compelled towards schooling and work online from home. This would mean that all projects, research, tests, and meetings were conducted over Zoom or other online meeting platforms. Laboratories were shut down or only a limited number of people were allowed to enter to conduct the necessary research. This paper discusses how the COVID-19 pandemic affected research process and experiments within various aspects of the …

A Decade Of Research Exploring Biology And Communication, Justin P. Boren, Alice E. Veksler

Communication Research Trends

No abstract provided.

Exploring The Role Of Cyclin D1 In Regulating Thermogenic Program In Brown Adipose Tissue, Chengrui Qiu

Biochemistry and Molecular Biology Scholarship

Adipose tissue plays a multifaceted role in regulating metabolic health and contributing to the pathophysiology of various diseases. Brown Adipose Tissue (BAT), a vital organ that senses different environment cues such as cold stress and diet and then undergoes non-shivering thermogenesis in mammalian animals, enhancing energy expenditure to combat obesity. In our recent published study, we found that the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway exhibits doubleedge effects in regulating thermogenic function, with opposite role in BAT and white adipose tissue (WAT). To further investigate the molecular mechanisms underlying the dual role of mTORC1 in thermogenic regulation, …

Strength Training Can Modulate Urinary Adipokine Levels In Healthy Young Males, Marcelo Henrique Salviano De Faria, Lucélia Scarabeli Silva Barroso, Antonio Felipe Souza-Gomes, João Luís Vieira Monteiro De Barros, Adriana Maria Kakehasi, Erica Leandro Marciano Vieira, Ana Cristina Simões E Silva, Albená Nunes Silva

International Journal of Exercise Science

International Journal of Exercise Science 18(2): 107-118, 2025. Adipose tissue stores energy in fat-rich adipocytes, which can produce and release several adipokines and modulate body metabolism. Exercise may induce adipokine production in adipocytes; however, the relationship between the two remains unclear. Few studies have shown the relationship between adipokines and strength training. Thus, we aimed to evaluate the acute and chronic effects of strength training (ST) on urinary adiponectin, leptin, and resistin levels. Twelve untrained young men (23.42 ± 2.67 years) were included in this study. Body composition was evaluated at baseline and after completing of the training protocol using …

A New Approach: Using Biometric Technology To Explore The Physiological Stress Of Working In Child Welfare, Austin Griffiths, Kim Link, Kara Haughtigan, Oliver Beer, Lindsey Powell, David Royse

School of Health Professions

Job stress among child welfare professionals affects their mental and physical health and is associated with negative outcomes. Researchers have used self-report measures to document the stress experienced by those in the child welfare field, and this is the first study to use biometric technology across 72 h to identify physiological indicators of stress, recovery, and sleep in frontline child welfare workers in mostly rural areas (n = 32). A stress profile of the participants is presented on their heart rates, mean time-stressed, percent of time stressed, mean time relaxed, percent of time relaxed, mean sleep time, mean RMSSD in …

Central Washington University 2025-2026 University Catalog, Central Washington University

Course Catalogs

No abstract provided.

"Dental Health For Mental Wealth": A Comprehensive Analysis Of The Underexplored Impact Of Oral Health And Behaviors On Neurobiology And Psychological Well-Being, Brooke C. Beck

Mahurin Honors College Capstone Experience/Thesis Projects

This thesis explores the link between oral health and psychological state, specifically, the effect of oral health on psychological state and how appropriate oral health impacts this relationship. A review of the literature was conducted and studies interpreted within the scope of oral health’s impact on psychological health and detailing some of the pathways proposed for such a link. The literature search was limited to the English language from well-known databases mainly from 2015 to 2025. A few outliers are present to include foundational information.

The effects of oral disease and oral self-care behaviors were dissected through a biochemical perspective, …

Serotonin-Mediated Sickness Behavior, Audrey Harnagel

Student Theses and Dissertations

Serotonin is an ancient and powerful neuromodulator that regulates diverse processes from fundamental physiology to complex emotions. Due to the many functions of serotonin distributed throughout the body and brain, governing principles of serotonin signaling have remained elusive. There is particular interest in how serotonin modulates internal states given that serotonin dysregulation is a feature of many psychiatric diseases. In this thesis, I use the simplified serotonergic system of C. elegans to explore how serotonin governs the internal state of sickness. In addition to activating the immune system and remodeling physiology, pathogenic infection results in adaptive behavioral changes that promote …

Optimal Tissue Clearing Of Gastric Cancerous Organoids Imaged Via High Resolution Light Sheet Microscopy, Lauren D. Lieu

2025 Fall Honors Capstones Projects - Archive

While the rate of surviving a myocardial infarction has increased in the past 60 years from 60% to 90%, the rate of Americans developing chronic heart disease such as heart failure, arrhythmias, and hypertensive heart disease has risen. This has led to the development of imaging technology such as Light Sheet Microscopy (LSM) and Light Field Microscopy (LFM) to study heart contractility and congenital heart disease via models such as cancerous organoids or Zebrafish. However, LSM and LFM results are highly dependent on the quality of the staining and cleared samples. This study looks to add to the growing field …

Development Of Human Neuronal Microphysiological Models And Subsequent Integration Into Multi-Organ Platforms For Evaluation Of Therapeutic Efficacy And Off-Target Toxicity, Aakash Patel

Graduate Thesis and Dissertation post-2024

Microphysiological systems are a rapidly growing field of research for modeling of physiological processes and disease in an in vitro environment. The translatability and cost effectiveness of these platforms make them a valuable tool for drug discovery, allowing investigation of both efficacy and off-target toxicity either as a replacement or supplement to traditional animal models. Neurological disorders in particular are often difficult to emulate in an animal model, making the development of these models a highly useful area of research for both elucidation of brain function, as well as neurological disorders. Taking these models and integrating them into a multi-organ …

Analysis Of Kcnj2 Variants Associated With Wolff-Parkinson-White Syndrome, Elaine Vanterpool, Kerenlaime Bautista

Student Posters

Wolff-Parkinson-White (WPW) syndrome is a cardiac disorder characterized by an accessory electrical pathway, leading to tachycardia and arrhythmias. It is diagnosed via electrocardiogram (ECG), showing a shortened PR interval and delta wave. WPW is typically managed with medications, catheter ablation, or surgery. Although primarily caused by anatomical anomalies, emerging research suggests genetic factors, including ion channel mutations, may contribute to the condition. The KCNJ2 gene encodes an inward-rectifier potassium channel critical for cardiac excitability. Mutations in KCNJ2 are linked to Andersen-Tawil syndrome, a disorder featuring arrhythmias and muscle weakness, raising questions about its role in WPW. This study investigates whether …

Marmosets As Model Systems For The Study Of Alzheimer's Disease And Related Dementias: Substantiation Of Physiological Tau 3r And 4r Isoform Expression And Phosphorylation., Hasi Huhe, Sarah M Shapley, Duc M Duong, Fang Wu, Seung-Kwon Ha, Sang-Ho Choi, Julia Kofler, Yongshan Mou, Thais Rafael Guimaraes, Amantha Thathiah, Caroline M Watson, Lauren K H Schaeffer, Gregory W. Carter, Nicholas T Seyfried, Afonso C Silva, Stacey J Sukoff Rizzo

Faculty Research 2025

INTRODUCTION: Marmosets spontaneously develop pathological hallmarks of Alzheimer's disease (AD) including amyloid beta plaques. However, tau expression in the marmoset brain has been understudied.

METHODS: Isoforms of tau were examined by western blot, mass spectrometry, immunofluorescence, and immunohistochemical staining.

RESULTS: 3R and 4R tau isoforms are expressed in marmoset brains at both the transcript and protein levels across ages. Mass spectrometry analysis revealed that tau peptides in marmoset corresponded to the 3R and 4R peptides in human brain, with 3R predominating at birth and an ≈40%:60% 3R:4R ratios in adolescents and adults; tau was distributed widely in neurons, with localization …

The Association Of Vitamin D Supplement Intake On Cardiovascular Health Outcomes Among U.S. Adults, Using Nhanes Data., Lamisa Tanzim Ruhin

Graduate Research Theses & Dissertations

Background: Vitamin D, a fat-soluble nutrient essential for bone health and calcium homeostasis, has also been implicated in cardiovascular health outcomes. Despite extensive observational studies suggesting an inverse association between vitamin D deficiency and cardiovascular diseases (CVD), randomized controlled trials (RCTs) have yielded inconsistent findings regarding the efficacy of vitamin D supplementation in reducing cardiovascular risk.

Objective: This study investigated the association between reported vitamin D supplement intake and cardiovascular health biomarkers, specifically focusing on non-HDL cholesterol, among U.S. adults using NHANES 2021-2023 data.

Methods: A cross-sectional, quantitative analysis was conducted utilizing secondary data from NHANES. Participants aged 18 and …

International Society Of Sports Nutrition Position Stand: Nutritional Concerns Of The Female Athlete, Ralf Jäger, Jeffery L. Heileson, Sidney Abou Sawan, Broderick L. Dickerson, Megan Leonard, Richard B. Kreider, Chad M. Kerksick, Stephen M. Cornish, Darren G. Candow, Dean M. Cordingley, Scott C. Forbes, Grant M. Tinsley, Tindaro Bongiovanni, Roberto Cannataro, Bill I. Campbell, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak, Jeffrey R. Stout, Douglas S. Kalman, Jose Antonio

Faculty Publications

Position Statement: The International Society of Sports Nutrition (ISSN) presents this position based on a critical examination of the literature surrounding the effects of long-chain omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on exercise performance, recovery, and brain health. This position stand is intended to provide a scientific foundation for athletes, dietitians, trainers, and other practitioners regarding the effects of supplemental ω-3 PUFA in healthy and athletic populations. The following conclusions represent the official position of the ISSN: Athletes may be at a higher risk for ω-3 PUFA insufficiency. Diets rich in ω-3 PUFA, including supplements, are effective strategies for …

Ai-Infused Discussion Boards: Enhancing Engagement, Reflection, And Academic Integrity In Anatomy And Physiology Education, Wade Dauberman

Teaching Repository of AI-Infused Learning

This paper presents the design, implementation, and evaluation of an AI-infused discussion board assignment that promotes ethical AI engagement, enhances student learning in anatomy and physiology, and addresses academic integrity concerns in higher education.

Presumptions Of Ai Malfunction: A Judicial Response To Ai Harms, Janine S. Hiller, Destynie J.L. Sewell

American University Law Review

In stark contrast to the recently revoked federal policy meant to incentivize the adoption of safe, secure, and trustworthy artificial intelligence systems, the July 2025 Winning the Race, America’s AI Action Plan succinctly summarizes its approach as “Build, Baby, Build!” Public discourse, as well, vacillates between artificial intelligence (AI) as a savior or an existential threat to society. To make effective decisions about AI governance, policy makers and regulators must not fail to recognize AI systems’ inherent weaknesses. Furthermore, whether citizens have recourse from harmful AI applications will also turn upon judicial balancing of competing interests between technological advancement and …

Program And Proceedings: Nebraska Academy Of Sciences 1880–2025, 145th Anniversary Year, One Hundred-Thirty-Fifth Annual Meeting

Nebraska Academy of Sciences: Programs and Proceedings

Program

Aeronautics and Space Science

Biological and Medical Sciences

Biology

Chemistry

Earth Sciences

Science Education

Anthropology

Applied Science and Technology

Physics and Engineering

Forensic Sciences

Ecology, Sustainability, and Environmental Science

Maiben Lecture: Mary Ann Vinton, "State of the Academy"

Friends of Science Awards: David Crouse and Daniel Sitzman