Digital Commons Network^™

Effects Of Hyperglycemia In Cognition And Sex, Erin E. Mcdonald

Senior Honors Theses

An empirical study tested the effects of Type 1 Diabetes (T1D) on cognitive function in a hyperglycemic mouse model. Strong correlations between mental illnesses, such as major depressive disorder, neuropathologies like Alzheimer’s disease, and diabetes suggest comorbid pathology. Considering the prevalence of both T1D and cognitive decline within the general population, the findings were relevant and aimed to identify early signs of cognitive decline in diabetic patients. Behavioral tests and immunohistochemical staining were utilized to determine the cognitive function of the mice, revealing decline or deterioration caused by hyperglycemia. Data gathered from the hyperglycemic or control mice were analyzed based …

Comparative Analysis Of Human And Drosophila Melanogaster Circadian Rhythms Using Dam Software, Maria Eduarda Couto Dourado, Alessia Zedde, Melissa Lehman, Kimberly D. Rowland

Student Publications and Presentations

This study aims to analyze human sleep patterns and compare them to Drosophila melanogaster (fruit fly) circadian rhythms using Drosophila Activity Monitoring (DAM) software. The primary objective is to determine the similarities between human and Drosophila sleep-wake cycles under controlled conditions. Human subject data will be collected through an anonymous survey assessing sleep duration, bedtime, wake-up time, mood variations, and lifestyle factors such as work schedule and caffeine intake. The collected data will be processed using DAM software to analyze human sleep-wake cycle patterns. To compare circadian rhythms, human-derived sleep patterns will be integrated into the DAM system to regulate …

Exploring The Essence Of Teacher Retention In A Christian School: A Multiple Case Study, Philip Rey Regualos

Doctoral Dissertations and Projects

The purpose of this exploratory multiple case study was to understand the factors that contributed to teacher retention at two pre-K–12 Christian school associations of three schools, the Midwest Evangelical Christian School Association (MECSA) and the Rural Area Christian School Association (RACSA). In the research, teacher retention was generally defined as a teacher who is currently employed and intends to return next academic year as a teacher at this association. The theory guiding this study was Maslow’s hierarchy of needs. The central research question guiding the study is: How do teachers describe the factors that motivate them to return to …

Seg-Swin: A Dual-Attention Transformer Model For Advanced Amd Classification And Lesion Detection Using Color Fundus Imaging, Niveen Nasr El-Den, Mohamed Elsharkawy, Ibrahim Saleh, Ali H. Mahmoud, Mohammed Ghazal, Ashraf Khalil, Ashraf Sewelam, Hani Mahdi, Ayman El-Baz

All Works

Age-related macular degeneration (AMD) is a prevalent retinal disorder in the elderly, often leading to significant vision impairment. The diagnosis of AMD is confirmed through various medical imaging modalities, with color fundus photography (CFP) being a primary tool. The detection and staging of AMD-severity depend on several factors, including the number and size of drusen, the presence of pigmentary changes, geographic atrophy, and neovascularization, all of which are identifiable through CFP. In this study, we introduce an innovative dual-vision transformer-based network designed to automatically detect AMD and classify its severity into either dry AMD or wet AMD using CFP. Early …

The Implications Of The Scientific Developments Behind Oxidative Stress, Heat-Shock Proteins, And Antioxidants On Neurodegenerative Pathology, Nolan Wilbourn

Honors Theses

Homeostasis is essential for the health and development of all organisms, serving as a universal defense mechanism that ensures the stability of physiological processes faced with external and internal stimuli in the form of health challenges (Archana et al., 2017). Maintaining homeostasis is crucial for our health, as it helps keep the body's internal balance. However, this delicate equilibrium is challenged by various environmental factors, such as diet, exposure to chemicals, and fluctuations in temperature (Collier et al., 2017). These disruptions can lead to dysfunction in cellular processes, particularly affecting the production and regulation of proteins vital for biological functions. …

Fd&C Red Dye No. 40 (Allura Red) Effects On Non-Human Animal Testing: A Systematic Review, Vilate Winfrey

Honors Theses

Artificial food dye is added to foods to enhance their color and appearance for consumers. This systematic review aims to review the literature on Red Dye No. 40 and its effects on non-human animals. Studies were included if (a) exposure to Red Dye No. 40 was the independent variable, (b) nonhuman animals were the subjects, and (c) at least one behavioral, neurological, or physiological dependent variable was reported. An article search was conducted with Scopus Elsevier. An abstract review was conducted to determine whether the articles met all inclusion criteria. The author conducted a multi-stage application of inclusion criteria to …

Age Of Anaerobic, Aerobic, And Skill-Based Olympic Athletes 1988 - 2024, Corban J. Ruiz, Iliana G. Hernandez, Edward K. Merritt

International Journal of Exercise Science

International Journal of Exercise Science 18(3): 404-414, 2025. The age at which athletes compete at a high-level provides understanding of human physiology, development, aging and skill refinement. The Olympics, with high-level performances across events with differing metabolic demands, provide unique data for analysis of optimal performance age given the type of performance required. The aim of this study was to classify Olympic events from 1988-2024 into aerobic, anaerobic, mixed, or skill, and compare male and female athlete ages in each classification. Events of maximal effort under 2-minutes duration were classified as anaerobic. Events longer than 5 minutes were classified as …

Understanding Strain-Level Dynamics In Gut Commensal-Pathogen-Host Interactions, Anna Louise Deveaux

Arts & Sciences Graduate Student Theses and Dissertations

The human gut microbiome is a consortium of trillions of bacteria, archaea, fungi, and viruses that colonizes the gastrointestinal tract and promotes health under homeostatic conditions. This microbial community trains the immune system, modulates inflammation and anticancer immunity, promotes cardiometabolic health, enables nutrient extraction, and prevents pathogen overgrowth. The latter function manifests through colonization resistance, in which microbes occupy spatial and nutritional niches thereby excluding pathogens from the community entirely, and through limiting pathogen population growth if colonization occurs. These roles are facilitated by complex host-microbe and microbe-microbe interactions that underlie differences in susceptibility to microbiome-mediated infectious diseases. The strain-level …

Creatine Supplementation Is Safe, Beneficial Throughout The Lifespan, And Should Not Be Restricted, Richard Kreider, Andrew Jagim, Jose Antonio, Douglas Kalman, Chad Kerksick, Jeffrey R. Stout, Robert Wildman, Rick Collins, Diego A. Bonilla

Faculty Scholarship

As researchers investigating creatine supplementation, we have become increasingly concerned about reports that government agencies are attempting to restrict the sale of dietary supplements, including dietary supplements containing creatine, to children and adolescents. Creatine is a naturally occurring compound found in every cell in the human body that plays a critical role in cellular metabolism. The daily turnover of creatine is about 2–4 grams/day, depending on muscle mass and physical activity levels (1, 2). About half of the daily need for creatine is synthesized in the body from amino acids (arginine, glycine, methionine) and stored as free creatine or phosphocreatine …

Food For Thought: The Impact Of The Gut-Brain Axis On Mental Health, Emily S. Miiller

Honors Thesis

Research regarding the role of the human microbiome has grown over the years as professionals develop a better understanding of the gut-brain axis. New studies and expanding knowledge on the relationship between the nervous system and gut microbiome promote a deeper understanding of the impact of diet on mental health. Diet plays a crucial role in maintaining a healthy balance between the gut and the brain. Incorporating nutritional modulators, such as probiotics, prebiotics, and vitamins, is crucial for supporting the gut-brain axis by influencing neurotransmitter production, managing inflammation, and promoting the growth of beneficial gut bacteria. On the other hand, …

Automated Plant Morphological Assessment And Microbial Community Monitoring In Simulated Lunar Regolith, Collin R. Topolski

Doctoral Dissertations and Master's Theses

Upcoming lunar bases will need to leverage in-situ resources to ensure long-term sustainability and reduce mission costs. One key challenge is food production, which could be addressed by growing crops in lunar regolith-based substrates. However, lunar regolith lacks essential nutrients, requiring organic amendments to support continuous plant cultivation. This study examined the impact of manure-amended lunar regolith simulant on Mizuna mustard growth while assessing microbial community diversity and functionality. To support this effort, a custom software pipeline utilizing an open-source library, PlantCV, was developed to automatically track plant leaf area and height via image analysis. Results indicated that amended rhizosphere …

Turbulence And Energetic Ion Production In The Partially Magnetized Hollow Cathode Plume, Margaret Mary Mooney

Dissertations

Hall effect thrusters (HETs) are the most widely used electric propulsion (EP) device for in-space satellite propulsion. EP devices provide high efficiencies for extended mission lifetimes and low thrust for precision maneuvers. The hollow cathode is a critical HET component and undergoes extensive lifetime testing in addition to the lifetime testing of the full HET. Significant density gradients, non-Maxwellian electron behavior, and magnetic fields sufficiently strong enough to magnetize electrons in hollow cathode plumes create favorable conditions for the formation of plasma instabilities, which have an impact on cathode lifetime. Cathode qualification testing is typically conducted independently and includes a …

The Short-Term Effects Of Fluctuating Sleep Timing On Cardiovascular And Metabolic Health, Gabe Dennett

Inquiry Journal Spring 2025

This study investigates the short-term effects of an acute circadian fluctuation protocol on the cardiovascular and metabolic health of young recreationally active college students. While the deleterious effects of sleep deprivation on a person’s health are wide reaching and well established, circadian misalignment—the discrepancy between biological clocks and external cues—remain under investigated. This research highlights “social jet lag,” a common phenomenon among young people wherein inconsistent sleep and wake times driven by social, school, work, or other commitments creates irregularity in hormonal rhythms, autonomic, and metabolic processes; emphasizing the emerging recognition that not just how much we sleep, but when …

Therapeutic Role Of Bioactive Peptides Derived From Hemoglobin, Priya Antony Pereppadan

Dissertations

Bioactive peptides are peptide fragments derived from the proteolytic cleavage or maturation of functional proteins that have shown promising therapeutic potential in addressing major health challenges, including type 2 diabetes, hypertension, and pain management. Diabetes is characterized by high blood glucose levels due to insufficient insulin production or utilization. There are several therapeutic targets for managing diabetes, and one key target is dipeptidyl peptidase IV (DPP IV) due to its role in glucose metabolism. In hypertension, angiotensin-converting enzyme 1 (ACE1) is critical for regulating blood pressure by forming angiotensin II, and its inhibition represents an established treatment strategy. Additionally, the …

Human-Aware Reinforcement Learning For Adaptive Human-Robot Teaming, Saurav Singh

Theses

The rise of Industry 5.0 has shifted robotic systems toward human-centric design, emphasizing collaboration between humans and machines. While collaborative robots (cobots) are equipped with sensors for safety, they typically overlook human internal states such as fatigue, stress, and workload—factors that significantly impact performance. This lack of awareness limits their ability to adapt and collaborate effectively, particularly in dynamic, real-time environments where human conditions fluctuate. This thesis introduces a novel framework that integrates human internal states into robot decision-making to enhance human-robot collaboration. This research leverages reinforcement learning (RL) to develop methods that enable robots to adapt their behavior based …

The Cellular Trafficking And Targeting Of Angiotensin-Converting-Enzyme-2 (Ace2) And Neutral-Amino-Acid-Transporter (B0at1) Variants: Implications For The Pathogenesis Of Associated Diseases And Therapy, Nesreen Fayyad Alkhofash

Dissertations

Angiotensin-converting enzyme 2 (ACE2) and the neutral amino acid transporter B0AT1, encoded by SLC6A19, are membrane proteins with pivotal roles in human physiology. ACE2 is involved in regulating blood pressure and serves as the cellular entry receptor for SARS-CoV-2, while B0AT1 facilitates amino acid absorption in the intestine. The interplay between ACE2 and B0AT1, particularly their physical interaction and co-expression in the intestine, underscores their relevance in both normal physiology and disease. Dysregulation of these proteins has been implicated in conditions such as hypertension, and Hartnup disease and they have been usurped by SARS-CoV-2 to cause COVID-19. Despite their …

19th Annual Research In The Capitol [Program], March 31, 2025, University Of Northern Iowa. University Honors Program. Iowa State University. Honors Program. University Of Iowa. Honors Program.

Research in the Capitol Programs

Program of research presentations given at the Capitol by students from the University of Northern Iowa, Iowa State University, and the University of Iowa.

The Shorthorn: February 07, 1939

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

Effects Of Prebiotic Phytocompound Administration In Gestational Diabetic Dams And Its Influence On Offspring Cognitive Outcomes, Gayathri Jagadeesan, Tushar K Das, Jennifer M Mendoza, Ghalya Alrousan, Maria P Blasco-Conesa, Parimelazhagan Thangaraj, Bhanu Priya Ganesh

Faculty, Staff and Student Publications

Gestational diabetes mellitus (GD)-induced gut dysbiosis in pregnant mothers may increase the risk of cognitive impairment and neurological disorders in both the mother and offspring as they age. Restoring gut balance could improve cognitive outcomes for both. Despite advancements in GD treatment, side effects have increased, and long-term neurocognitive impacts on offspring born to GD mothers remain underexplored. This study uses a GD mouse model, inducing pancreatic dysfunction in 3-month-old pregnant C57BL/6J mice with Streptozotocin. The efficacy and mechanism of the prebiotic phytocompound green leaf extract (

Transgenerational Impacts Of Covid-19: Exploring The Epigenetic Impacts Of Sars-Cov-2 Infection On Parental Reproductive Health And Offspring Development, Isaac Mckay Stirland

Theses and Dissertations

The mechanisms and consequences of SARS-CoV-2 infection, including clinical manifestations, immune response, pathogenicity, long-term sequelae, etc., have been studied in detail following the 2019 pandemic however, very little has been done to explore the interplay between SARS-CoV-2 and host DNA methylation. Given the role of DNA methylation in genetic regulation, genomic imprinting, and induction of transgenerational effects, an understanding of viral interaction(s) with the host methylome is imperative in promoting reproductive and developmental health. Numerous reports describe infections with similar pathogenicity to SARS-CoV-2 and their correlation to altered host tissues at the epigenetic, physiologic, and macroscopic level. These reported epigenetic …

Grounded In Touch: The Science Behind Anxiety Relief And Human Connection, Misty Rhoads Ph.D. Czb, Mary Murphy M.A., Lmt, Czb, Mary L. Behrens Pt, Czb, Rhonda Salvo Pt, Czb, Sarah-Elizabeth Anderson Lmt, Czb, Clare Gowen Pt, Czb, Dawn Humbles Lsh, Czb, Veronica Quarry Pt, Czb, Deborah Rosene Ph.D., Czb, Wendy Tribelhorn Lmt, Czb, Jared Urcheck L.Ac, Czb, Deanna Waggy Otr, Czb

Journal of Transformative Touch

Background: Anxiety disorders are among the most pervasive mental health challenges worldwide, affecting individuals across all demographics and socioeconomic backgrounds. As a leading contributor to disability and diminished quality of life, anxiety continues to rise in prevalence, exacerbated by global crises and societal stressors. This study explored how Zero Balancing (ZB) supports individuals with anxiety. Researchers hypothesized that ZB would lower the perceived severity of general anxiety and reduce perceived anxiety symptoms.

Methods: A concurrent mixed-methods phenomenological research design was utilized to honor the holistic nature of bodywork and explore participants' lived experiences. This national study involved 320 ZB sessions …

Bone Turnover Markers Response To Aerobic Versus Resistance Exercise Among Postmenopausal Saudi Women, Shehab Mahmoud Abd El-Kader, Shehab Mahmoud Abd E-Kader, Subhi Mustafa Neveen Refaey, Amany Gomaa Atiaa, Qawagzah

Journal of Medical Rehabilitation Science

Background: Menopause is characterized with low bone turnover biomarkers (BTMs) with faster reduction of bone mass and high fracture risk. Osteoporosis is considered as a major health related problem among Asian postmenopausal women. Physical exercise is an accepted modality in both primary and secondary prevention fracture related to osteoporosis. However, our understanding regarding the best exercise training program to prevent osteoporosis among postmenopausal women is incomplete.  Objective: The present study was designed to examine aerobic versus resisted exercise training effects upon postmenopausal Saudi women markers of bone turnover. Material and Methods: One hundred Saudi postmenopausal women, their age ranged from …

Doc 2025-02 Neuroscience Co-Major, Full Program Proposal, University Of Dayton. Department Of Biology, College Of Arts & Sciences

Senate Documents

The Department of Biology in the College of Arts & Sciences (CAS) proposes to establish an innovative Co-Major in Neuroscience program. This Co-Major will comprise a new program offering in the Department of Biology complementing the existing Minor in Neuroscience.

2025-3-14 Minutes Of The Academic Senate, University Of Dayton. Academic Senate

Academic Senate Minutes

Approved minutes of a meeting of the Academic Senate of the University of Dayton.

Academic And Non-Academic Barriers Impacting Student Success And Retention In Corequisite English, Stephanie Tolliver Hyman

Morehead State Theses and Dissertations

A capstone submitted in partial fulfillment of the requirements for the degree of Doctor of Education in the Ernst and Sara Lane Volgenau College of Education at Morehead State University by Stephanie Tolliver Hyman on March 13, 2025.

Exploring The Effects Of Indoor Plants On Executive Function, Jose David Romero Silva, Aj Heritage

Master's Theses & Other Graduate Student Works

The link between greenery in schools and cognitive performance is underexplored, even with evidence of its benefits in other settings. Research indicates that adding green plants to an office can improve mood and lower stress (Bergefurts et al., 2021). This study explored the factors behind the psychological benefits of indoor plants on executive function in college students. The study proposed two competing hypotheses based on Attention Restoration Theory (ART) and Enrichment Theory. Hypothesis I: Based on the Attention Restoration Theory, integrating plants into the classroom benefits students’ executive function by giving them a sense of relief from fatigue. Hypothesis II: …

Dementia In A Resource-Constrained Sub-Saharan African Setting: A Comprehensive Retrospective Analysis Of Prevalence, Risk Factors, And Management At The Only Neuropsychiatric Facility In Northeastern Nigeria, Ibrahim Abdu Wakawa, Umar Baba Musami, Suleiman Hamidu Kwairanga, Placidus Nwankuba Ogualili, Mohammed Yusuf Mahmood, Muhammad Abba Fugu, Mohammed Mala Gimba, Muktar Mohammed Allamin, Zaharadeen Umar Abbas, Chinedu Momoh

Brain and Mind Institute

INTRODUCTION: Dementia prevalence is increasing in sub-Saharan Africa, poten-tially due to population growth and aging. Resource-constrained settings such asNortheastern Nigeria face challenges in dementia management.

METHODS: We assessed dementia burden and management at the Federal Neuropsy-chiatric Hospital Maiduguri, the only neuropsychiatric facility in Northeastern Nigeria.This retrospective analysis included patient records from 1999 to 2023 for individuals60 year of age and older with a dementia diagnosis.

RESULTS: Of the 1216 cases reported, Alzheimer’s disease (60.5%) was the mostcommon subtype, followed by vascular dementia (24.5%). Hypertension (41.6%) wasthe most frequent comorbidity. Memory loss was present in all cases, whereasbehavioral …

Healthcare Systems-Based Exercise Oncology Programs: Emphasizing And Speaking The Language Of The Clinic And Patient, Jessica S. Gorzelitz, Mary A. Kennedy, Kim Dittus, Sami Mansfield, Karen Wonders, Pamela A. Hansen, Adriana M. Coletta, Neil M. Iyengar, Kelley Covington Wood, Anna L. Schwartz, Melanie Potiaumpai, Anna Campbell, Kathryn H. Schmitz

Research outputs 2022 to 2026

Introduction Exercise oncology services are evidence based and aim to reduce symptom burden and potentially improve outcomes in adults living with and beyond cancer. Healthcare system-based exercise oncology programs include exercise prior to, during, and after treatment, but the implementation and maintenance of these programs are not well documented. We aimed to describe five healthcare system-based exercise oncology programs in the United States, including service information and barriers to and facilitators of program success. Methods This was a qualitative case study of five healthcare-based exercise oncology programs in the United States informed by the Exploration, Preparation, Implementation, Sustainment framework. We …

A Reinforcement Learning Approach For Maneuvering And Firing Decisions In Sead Operations, Nathaniel Garcia

Theses and Dissertations

The integration of automated processes in defense continues to expand, enhancing the lethality of military forces. Artificial intelligence accelerates decision-making cycles, removes the constraints of human-operated hardware, and improves coordination by enabling seamless integration across multiple systems. Suppression of Enemy Air Defenses (SEAD) missions are critical to the United States (U.S.) military, as they neutralize hostile air defense systems, ensuring air superiority and enabling safe and effective operations for aircraft in contested environments. Therefore, it is necessary to pair emerging autonomous capabilities with an important mission set in defense. This research investigates the Autonomous Unmanned Air-to-Ground Strike (AUAGS) problem, modeling …

Relationships Between Brain Glucose Metabolism Patterns And Impaired Glycemic Status: A Systematic Review Of Fdg-Pet Studies With A Focus On Alzheimer's Disease, Setareh Soltani, Mahsa Dolatshahi, Sara Soltani, Kian Khazaei, Maryam Rahmani, Cyrus A Raji

2020-Current year OA Pubs

It is well-established that individuals with type 2 diabetes have an increased risk of developing cognitive impairment and Alzheimer's disease (AD). However, it is not fully determined how insulin resistance and type 2 diabetes are related to AD-related brain glucose metabolism abnormalities. For this aim, we performed a systematic review of the studies investigating the association between cerebral glucose metabolism and glycemic status, including diabetes, insulin resistance, or hyperglycemia. Medline, Embase, and Cochrane databases were searched (till February 2, 2025). All English full-text papers studying 18F-FDG-PET that investigated the association between cerebral FDG uptake or cerebral metabolism rate and glycemic …