Digital Commons Network^™

Functional Characterization Of Uhrf1 Variants In Facilitating Dna Methylation, Bigang Liu, Kaila Nayvelt, Swanand Hardikar, Kimie Kondo, Marcos R Estecio, Xiaodong Cheng, Taiping Chen

The Brown Foundation: Institute of Molecular Medicine

Ubiquitin-like with plant homeodomain (PHD) and really interesting new gene (RING) finger domains 1 (UHRF1) is essential for DNA methylation inheritance. However, the functional impacts of several natural and engineered UHRF1 variants are either insufficiently characterized or obscured by conflicting results, with some discrepancies likely stemming from cellular toxicity and adaptive responses induced by DNA methylation changes. In this study, we utilized mouse embryonic stem cells (mESCs)-which uniquely tolerate the complete loss of DNA methylation-to evaluate the functional consequences of clinical mutations, isoform variation, and epitope tagging. Using rescue experiments in Uhrf1-deficient mESCs, we characterized two UHRF1 mutations identified in …

Da Mosang Tarsier Series: Developing Digital Bullying Prevention Materials For Filipino Parents Of Grade School Students, Rudy M. Danganan Jr., Ann Christine V. Braga, Maria Kristina S. Alfonso, Romelito Manuel D.S. Clorina, Ma. Regina Hechanova

Children and Families

Bullying remains a significant public health and educational concern worldwide and is particularly prevalent in Philippine public schools, with Grade 7 students identified as a vulnerable group. Although the Anti-Bullying Act of 2013 (Republic Act No. 10627) mandates school-based policies and procedures, persistent implementation gaps underscore the need to strengthen home–school partnerships and equip parents with practical, culturally grounded response strategies. This paper describes the development of the Da Mosang Tarsier Series, a set of digital psychoeducational comic strips designed for Filipino parents of Grade 7 students. Guided by a user-centered design (UCD) framework, the project began with a Generative …

Medical, Socioeconomic, And Geographic Disparities In Primary Health Care Access And Utilization: A Population-Based Study Of 8038 Individuals Aged One Year And Older In Rural Uganda, Saadiyah Mayet, Christin Puthur, Betty Nabatte, Benjamin Tinkitina, Christopher Opio, Yin-Cong Zhi, Narcis Kabatereine, Goylette Chami

Internal Medicine, East Africa

Background There is limited data on trends in primary health care (PHC) access and utilisation in rural sub-Saharan Africa, with a particular lack of knowledge on disparities beyond geographic barriers.

Methods A cross-sectional study was conducted within the community-based cohort, SchistoTrack. 2191 households were randomly sampled from 52 rural villages in Pakwach, Buliisa, and Mayuge Districts in Uganda. All household members aged one year and older were surveyed between 2022–2024, resulting in 8038 individuals with baseline health access information. Key outcomes included any care sought within the month preceding the study, type of care sought, and usual source of care. …

Just Opt For Caesarean Section And Pick The Birthdate': A Qualitative Study Exploring Women's Delivery Preferences After Caesarean Section In Urban Tanzania, Daudi Gidion, Columba Mbekenga, Miriam Mgonja, Marleen Temmerman, Muzdalfat Abeid

Obstetrics and Gynaecology, East Africa

Objectives To explore perspectives, preferences and decision-making regarding mode of delivery after a previous caesarean section among women in urban Tanzania.

Design A descriptive qualitative study using semi-structured in-depth interviews. Data were analysed using thematic analysis.

Setting A private tertiary hospital in Dar es Salaam, Tanzania.

Participants 11 women with one previous caesarean section who delivered at the study site were interviewed on the third day after delivery. Participants were purposively sampled to include both modes of delivery: five women underwent repeat caesarean section and six attempted a trial of labour after caesarean (TOLAC).

Results Thematic analysis identified four key …

Health Beliefs And Lung Cancer Screening Uptake Among Eligible Asian Americans In Philadelphia, Pennsylvania, United States, Julia G. Katcher, Kuang-Yi Wen, Christine S. Shusted, Jessica Liang, Kyunghee Koh, Hee-Soon Juon, Julie Barta

Department of Medical Oncology Faculty Papers

OBJECTIVE: Asian Americans experience disproportionately late-stage lung cancer diagnoses and lower lung cancer screening (LCS) rates than other racial groups. This study evaluated the association between the

METHODS: This pilot randomized controlled trial, conducted April 2023-January 2024 within a Philadelphia health system, tested a culturally and linguistically tailored intervention led by community health workers. LCS completion and LCS-Health Belief Scale (LCS-HBS) responses were compared between control and intervention participants (

RESULTS: LCS completion was higher in the intervention group (45%) than in the control (31.3%). Control participants who completed LCS reported higher perceived lung cancer risk, greater perceived benefits, and …

2026 July, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for July of 2026.

The Razorback Educator, Carole Shook Dr., Lynn Meade, Sheri Deaton, Faith Lessner, Karl Schubert, Gretchen Scroggins, Rachel Glade, Treisha Peterson, Flint Harris, Tamara Snyder, Kim Mccomas, Kim Mccomas, Auston Jones, Eric Button

The Teaching Academy Publications

The Razorback Educator is a joint publication of the University of Arkansas Teaching Academy and the Wally Cordes Teaching and Faculty Support Center.  It is designed to share teaching innovations related to the Scholarship of Teaching and Learning.  Faculty from multiple disciplines author the publication.

Aadej Comm 12 2 2026

AADEJ - The Communicator

The Communicator is the official publication of the American Association of Dental Editors & Journalists (AADEJ), promoting awareness of the association’s activities and offering valuable insights for dental editors and journalists to enhance their publications. It is published quarterly, distributed digitally via email to members, and posted on the Association’s website at aadej.org, with archives on ADA Commons. Regular contributions from the Editor-in-Chief, Executive Director, President, and Associate Editor cover various topics.

How Do Different Food Influents Affect Biogas Production, Process And Operational Stability, And System Performance In The Armfield W8, A Bench-Scale Anaerobic Digester, Jarko Rumbaoa, Anahita Adhikari

Rose-Hulman Undergraduate Research Publications

No abstract provided.

Economic Background And The Role Of Self-Compassion, Dixy Melendez

Psychology and Counseling Theses

Although self-compassion is established as a buffer against psychological distress, few studies examine its protective role alongside socioeconomic discrimination. This study used hierarchical multiple regressions and a hierarchical logistic regression to examine subjective social status, downward classism, self-compassion, and internalized shame as predictors of distress, academic anxiety, and academic task choice among college students, controlling for demographic variables. Greater self-compassion predicted less internalized shame, and greater downward classism predicted greater shame and distress. Self-compassion showed only marginal protective effects against distress after accounting for other variables. Internalized shame was the strongest, most consistent predictor, robustly relating to academic anxiety and …

The Neuropsychological Analysis Of The Effect Of Shame And Traumatic Memories In Paranoia: A Network Analysis, Anwesha Maitra

Clinical Psychology Dissertations

Paranoia is increasingly recognized as a multidimensional psychological phenomenon influenced by trauma-related distress, shame, maladaptive interpersonal experiences, and emotional functioning. Although these factors have been extensively associated with paranoia, their relationships with neurocognitive functioning, social cognition, and global functioning remain less well understood. The present study examined these relationships using traditional statistical analyses, network analysis, and machine-learning approaches in a non-clinical sample of 42 adults.

Participants completed self-report measures assessing trauma-related distress, childhood interpersonal experiences, shame, paranoia, depressive symptoms, fear of negative evaluation, self-esteem, and hostile attribution bias, in addition to a comprehensive neurocognitive battery, an emotion recognition task, and …

Mosaic Loss Of Y Chromosome Associates With Lung Function, Emphysema, And Epigenetic Aging, Woei-Yuh Saw, Kangjin Kim, Yichen Huang, Jeong H Yun, Xiaolong Ma, Jason Bacon, Yash Pershad, Daniel Levy, George T O'Connor, Eric Boerwinkle, R Graham Barr, Stephen S Rich, Jerome I Rotter, April P Carson, Laura M Raffield, Sina A Gharib, Traci M Bartz, Bruce M Psaty, Tamar Sofer, Kari E North, Robert C Kaplan, Elizabeth C Oelsner, Ani Manichaikul, Alexander G Bick, Paul Scheet, Alexander P Reiner, Nhlbi Trans-Omics For Precision Medicine Consortium, Yasminka A Jakubek, Paul L Auer, Michael H Cho, Dawn L Demeo

Faculty, Staff and Student Publications

Rationale: As the global population ages, identifying risk factors for age-related diseases, such as COPD, is crucial for public health. Mosaic loss of Y chromosome (mLOY) in blood cells is an age-related somatic mosaicism event, but its relationship with pulmonary health remains undercharacterized.

Objectives: To examine the association between mLOY and pulmonary outcomes in men.

Methods: Leveraging mLOY assessment (cell fraction ≥ 5%) in over 12 000 men, including 5097 from the COPDGene Study and 7235 from six additional cohorts in the Trans-Omics for Precision Medicine program, we investigated mLOY associations with respiratory outcomes and epigenetic aging using multivariable cross-sectional, …

Current Adoption Of The Prosthodontic Diagnostic Index For Clinical Care-A Cross-Sectional Survey Study, Esther O Kuyinu, Joseph B Breitman, Arthur Nimmo, Jay S Patel

Faculty, Staff and Student Publications

Purpose: To assess current utilization of the Prosthodontic Diagnostic Index (PDI), identify perceived benefits and limitations, and evaluate support for future updates.

Materials and methods: A survey regarding the use of the PDI was made available through email invitations to 68 US dental school prosthodontic/restorative department chairs (PD), 48 graduate prosthodontic program directors (GP), and 1834 private practice prosthodontists (PP) from the American College of Prosthodontists (ACP) member database. The results of this initial survey were inconclusive due to low response rates. The survey was also administered during the 2024 ACP Annual Session with an improved response rate for educators. …

Kras G12c And Kras G12d Respond To Lipid Metabolism In An Allele-Specific Manner, Neha Arora, Hong Liang, Walaa Kattan, Wantong Yao, Haoqiang Ying, Junchen Liu, Yong Zhou

Faculty, Staff and Student Publications

KRAS mutated at hotspots G12, G13, and Q61 possess profound allele-specific oncogenesis. Signaling of KRAS mutants is mostly compartmentalized to the proteolipid nanoclusters on the plasma membrane (PM), illustrating critical roles of spatiotemporal organization in KRAS cancer signaling. The activated GTP-bound KRAS molecules, including the wild type and mutants, have been traditionally thought to favor similar lipids. We recently reported distinct lipid sensing capabilities of different KRAS mutants, especially with KRASG12D favoring unsaturated lipids and KRASG12C gaining additional enrichment of saturated lipids. As such, KRAS mutants may respond to lipid acyl chain remodeling in an allele-specific manner. Lysophosphatidylcholine acyltransferase 1 …

Quantitative Analysis Of Peri-Implant Collagen Fiber Orientation Around External Hexagon And Morse Taper Implant Connections: A Dog Model Study, Daniel Sartorelli Marques De Castro, Jefferson David Melo De Matos, Jozely Francisca Mello Lima, Maria Angelica Rehder De Araujo, Mário Alexandre Coelho Sinhoreti, Daher Antonio Queiroz, Adriano Piattelli, Carlos Dos Reis Pereira De Araújo

Faculty, Staff and Student Publications

Background: Peri-implant soft tissue stability depends on the implant-abutment interface and collagen fiber organization. Unlike natural teeth, peri-implant fibers exhibit a less favorable orientation, potentially weakening the biological seal. Implant connection design may influence this collagen arrangement and tissue integrity.

Materials and methods: Eighteen immediately loaded implants (n = 9 per group) were placed in nine mongrel dogs. Group I received external hexagon implants, while Group II received Morse taper implants. After a 4-month healing period, animals were euthanized and specimens were processed for histological evaluation. Collagen fiber orientation was analyzed using polarized light microscopy and quantified with ImageJ software. …

Erk-Mediated Phosphorylation Of Yap Defines A Noncanonical Fgf Signaling Mechanism In Stem Cells, Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang-Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang

Faculty, Staff and Student Publications

While Fgf and Hippo-Yap signaling are fundamental for proper development, homeostasis, and disease, their crosstalk remains largely unknown. Here, we identified that Yap and Taz, canonical Hippo effectors, function as noncanonical effectors of Fgf signaling to maintain the proper function of neural crest (NC) lineages. NC cells are a multipotent stem cell population during vertebrate embryogenesis that contribute to numerous structures and diverse cell lineages, including craniofacial and cardiac tissues, neurons, and suture mesenchymal cells (SMCs), a specified cell population required for cranial bone growth and repair. We observed that activation of Fgf signaling in NC cells and NC-derived SMCs …

July 2026, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

Community & Connection Month

July is Community & Connection Month, a time to focus on building relationships, strengthening connections, and supporting one another. Whether it’s with friends, family, coworkers, or your campus community, meaningful connections play an important role in overall wellness. Strong social connections can improve mood, reduce stress, and help you feel more supported in everyday life.

Precise-Dyad: A Prospective Cohort Study Linking Maternal And Infant Health Trajectories In Sub-Saharan Africa, Marie-Laure Volvert, Robin Owino, Angela Koech, Onesmus Wanje, Isaac Mwaniki, Joseph Mutunga, Emily Mwadime, Geoffrey Omuse, Moses Mukhanya, Marvin Ochieng, Grace Mwashigadi, Agnes Mutua, Marleen Temmerman, Melissa Gladstone, Amina Abubakar, Helen Nabwera

Centre of Excellence in Women and Child Health

Purpose The PREgnancy Care Integrating Translational Science, Everywhere (PRECISE)-DYAD Study is a prospective observational cohort designed to investigate health outcomes among mother-child pairs (dyads) over the first 3 years of life in two contexts from sub-Saharan Africa. The primary objective of the study was to explore the effects of selected placenta-related complications, such as pregnancy hypertension, fetal growth restriction and preterm birth, on (1) Child health and development, and (2) Women’s health and well-being, including outcomes after stillbirth.

Participants The PRECISE-DYAD Study enrolled women (and their children) originally recruited into the PRECISE pregnancy cohort study in The Gambia and Kenya …

Automated Machine Learning And Satellite Image Data Fusion For Monitoring Water Quality In Mosaicked Landscapes, Sahar Rezaei

Graduate Theses and Dissertations

Despite the ecological, economic, and social importance of inland water bodies, they are increasingly impacted by human and natural drivers. Harmful algal blooms (HABs) and total suspended solids (TSS) are key indicators of water quality, and elevated concentrations pose significant ecological and public health risks. The spatiotemporal dynamics of these variables remain insufficiently understood in major river systems, including the Upper Mississippi River (UMR) and the Illinois River Basin (IRB). While in situ measurements provide accurate observations, they are costly and offer limited spatial and temporal coverage, restricting basin-scale monitoring. Remote sensing offers a powerful alternative; however, single-sensor approaches are …

His 127 Microhistories: A Lens Into The Past — Apartheid In South Africa Syllabus, Marta Millar

Open Educational Resources

The microhistory course introduces students to the study of history by exploring a particular event, individual, or issue, and its legacy. Students will read both primary source documents and modern texts to examine how the topic under consideration was shaped by, and in turn shaped contemporary culture.

This syllabus is for a course focusing on the history of apartheid in South Africa. Students will analyze the political, social, economic, and cultural aspects of the apartheid era. This includes understanding how segregationist policies developed in South Africa, what political transformations led to the implementation of the apartheid system, how different policies …

Using The Consolidated Framework For Implementation Research (Cfir) To Evaluate Complex School Settings, Carlie P. Coerver, Tricia A Zucker

Summer Research Program Abstracts

No abstract provided.

Hpv Vaccination Status And Associated Factors Among Postpartum Patients, Morgan L. Malonson, Sandhya B. Avula, Mary B. Rysavy

Summer Research Program Abstracts

No abstract provided.

Long-Term Quality Of Life For Patients With Merkel Cell Carcinoma Receiving Standard-Of-Care Adjuvant Radiation Therapy, Christian Paul D. Denolan, Kelsey N. Nordlund, Aya F. Salem, Devarati Mitra

Summer Research Program Abstracts

No abstract provided.

Anesthetic Considerations In Geriatric Oncological Patients: A Case Series, Allison Chen, Edward H. Tsai

Summer Research Program Abstracts

No abstract provided.

Optimizing Biomechanical Conditioning For Human Intestinal Organoids With An Enteric Nervous System, Cash L. Davis, Rachel Bordelon, Madushani Herath, Younus A Zuberi, Allison L. Speer

Summer Research Program Abstracts

No abstract provided.

Clinical Observation Of Glp-1ra And Substance Use (Cogs) Study Preliminary Data Outcomes, Akshara S. Narahari, Nzingha Johnson

Summer Research Program Abstracts

No abstract provided.

Neuroinflammatory Profiles In The Hippocampus Of Cognitively Resilient Alzheimer's Disease Patients, William H. Otte, Avery Matthews, Hongyu Wu, Ashlee Arizmendez, Michael E. Maniskas, Xinhai (Robert) Zhang, Chunfeng (Sheryl) Tan

Summer Research Program Abstracts

No abstract provided.

Jenny E. Carroll, Jenny E. Carroll

Faculty CVs

No abstract provided.

Milan Markovic, Milan R. Markovic

Faculty CVs

No abstract provided.

Joan Stringfellow, Joan Stringfellow

Faculty CVs

No abstract provided.