Digital Commons Network^™

Gen Z Hybristophilia: The Role Of Tiktok In Young Women’S Attraction To Deviant Men, Emma Virginia Treggia, Maria Ioannou, Calli Tzani, David Lester, Lucas Rogers, Thomas James Vaughan Williams, John Synnott, Michelle Drouin

Health Services and Informatics Research

This research explores hybristophilia (an individual’s sexual interest in and attraction to those who commit crimes) among Generation Z women, particularly through investigating how Gen Z female users interact with and feel about hybristophilic content and how this content impacts their attraction to offenders. Study 1 involved a content analysis of 66 videos and 91 comments on TikTok, identifying seven main themes: The Halo Effect, Actor-Offender Transference, Sympathy, Romance and APD, Protection and Loyalty, “I Can Fix Him,” Gen Z Irony, and Victim Fantasy. Study 2 used a cross-sectional survey with 95 women aged 18–27 to measure exposure to and …

Introduction To Clinical Psychology Syllabus (Psych 347), Valentina Nikulina

Open Educational Resources

No abstract provided.

Leveraging An Arts-Based Approach To Foster Engagement, Nurture Kindness, And Prevent Violence, Yok-Fong Paat, Diego Garcia Tovar, Nathan W. Myers, Max C. E. Orezzoli, Anne M. Giangiulio, Sarah L. Ruiz, Angela V. Dorado, Luis R. Torres-Hostos

School of Social Work Faculty Publications

Drawing from the insights of community partners, this study explored the roles and benefits of arts-based approaches to foster civic learning, critical media literacy, and community engagement. It also uncovered approaches to promote kindness, prevent violence, and combat online extremism, offering insights into strategies that may enhance community engagement and create a positive impact. We presented our model framework, a detailed case study of our project, and qualitative methods incorporating 15 interviews with our community partners to capture a broad range of perspectives and experiences. Interviewees were community partners who collaborated with our project in organizing events and activities using …

Pluriversal Energy Justice Through An Intersectional Feminist Lens: Analyzing Rural Electrification Injustices And Policy Pathways At Kenya's Garissa Solar Park, Carolyne M. Musyoka

Dartmouth College Master’s Theses

Located approximately 4 km from Raya village in Garissa County, the Garissa Solar Park spans

85 hectares and was envisioned as a flagship renewable energy project. Yet, despite its scale and proximity, the marginalized pastoralist community of Raya continues to face acute energy poverty, limited irrigation capacity, and exclusion from the material and socio-ecological benefits of the green energy project. This study critically examines the systemic energy injustices embedded within the Garissa Solar Park—specifically procedural, distributive, and recognition-based inequalities—and critiques the project’s failure to deliver on principles of equity, local meaningful and democratic participation, and gender inclusion.

The research assesses …

Olfaction And Plasma Biomarkers Of Alzheimer Disease And Neurodegeneration In The Atherosclerosis Risk In Communities Study, Srishti Shrestha, Xiaoqian Zhu, Michael E Griswold, Priya Palta, Kevin J Sullivan, Honglei Chen, Andrea Lauren Christman Schneider, Abhay Moghekar, Megan L Grove, Bharat Thyagarajan, James Russell Pike, Rebecca F Gottesman, B Gwen Windham, Thomas H Mosley, Jennifer A Deal, Vidyulata Kamath

Faculty, Staff and Student Publications

Background and objectives: Investigation of olfactory impairment, an early manifestation of Alzheimer disease (AD), in relation to plasma biomarkers of AD and neurodegeneration could provide insights into the disease's pathophysiology. Because few such studies based on large, diverse, community-based populations exist, we investigated associations of odor identification ability with plasma biomarkers of AD and other neurodegenerative pathologies in community-dwelling Black and White older adults.

Methods: This cross-sectional investigation included participants from the Atherosclerosis Risk in Communities study who attended visit 5 (2011-2013) and who completed olfactory testing and brain MRI examinations and had plasma biomarkers measured (namely, amyloid-beta [Aβ]42/Aβ40 ratio, …

Securing Americans' Genetic Information: Privacy And National Security Concerns Surrounding 23andme's Bankruptcy Sale. Hearing Before The House Committee On Oversight And Government Reform, United States House Of Representatives, 119th Congress, First Session., Margaret Hu

Congressional Testimony

No abstract provided.

Structural Basis For The Substrate Specificity Of Helix Pomatia Amp Deaminase And A Chimeric Adgf Adenosine Deaminase, Gundeep Kaur, John R Horton, George Tzertzinis, Jujun Zhou, Ira Schildkraut, Xiaodong Cheng

Faculty, Staff and Student Publications

Helix pomatia AMP deaminase (HPAMPD), an enzyme enriched in the foot muscle of the mollusk H. pomatia, exhibits deaminase activity on adenosine-5'-monophosphate (AMP). HPAMPD is the first member of the adenosine deaminase-related growth factor (ADGF) family to prefer the nucleotide AMP over the nucleoside adenosine. To investigate the substrate selectivity of HPAMPD, we determined its structure in both the apo form and in complex with the adenosine analogs pentostatin and pentostatin-5'-monophosphate. Structurally, HPAMPD adopts a fold similar to human ADA2, an ADGF family member. HPAMPD has acquired the ability to interact with the 5'-monophosphate group of AMP through polar and …

Enhancing Dementia Classification For Diverse Demographic Groups: Using Vision Transformer-Based Continuous Scoring Of Clock Drawing Tests., Mengyao Hu, Yi Lu Murphey, Tian Qin, Edmundo R Melipillán, Laura B Zahodne, Richard Gonzalez, Vicki A Freedman

Faculty, Staff and Student Publications

Objectives: Alzheimer's disease and related dementias significantly affect older adults' quality of life. The clock-drawing test (CDT) is a widely used dementia screening tool due to its ease of administration and effectiveness. However, manual CDT-coding in large-scale studies can be time-intensive and prone to coding errors and is typically limited to ordinal responses. In this study, we developed a continuous CDT score using a deep learning neural network (DLNN) and evaluated its ability to classify participants as having dementia or not.

Methods: Using a nationally representative sample of older adults from the National Health and Aging Trends Study (NHATS), we …

Engineering Lipid–Polymer Nanoparticles For Sirna Delivery To Cancer Cells, Arthur Manda, Abdulelah Alhazza, Hasan Uludağ, Hamidreza Montazeri Aliabadi

Pharmacy Faculty Articles and Research

Background: RNA interference (RNAi) is a powerful tool that can target many proteins without the expensive and time-consuming drug development studies. However, due to the challenges in delivering RNA molecules, the potential impact of RNAi approaches is yet to be fully realized in clinical settings. Lipid nanoparticles (LNPs) have been the most successful delivery system for nucleic acids, but targeted delivery to a solid tumor still eludes the developed LNPs. We hypothesized that specially designed low-molecular-weight PEIs can partially or completely replace the ionizable lipids for more accommodating vehicles due to the structural flexibility offered by polymers, which could …

Staff Education On Uti Screening, Antimicrobial And Antibiotic Resistance, And Poor Regimen Adherence, Shereen Robinson

Walden Dissertations and Doctoral Studies

This staff education project focused on enhancing nurses’ knowledge of urinary tract infections (UTIs) and antibiotic and antimicrobial resistance intended to promote screening for UTIs. The practice problem addressed was lack nurses’ knowledge of UTI screening and antibiotic resistance. Inadequate screening contributed to increased UTI rates, re-occurrences, and complications such as delirium. It was essential to address the issue because nurses are at the frontline regarding educating, screening, and providing care to patients with UTIs. Knowledgeable nurses can implement standard practices to ensure adequate screening for UTIs. Effective screening would enhance early treatment and minimize misuse and unnecessary antibiotic prescriptions. …

Exploring The Lived Experiences Of Rural Women Of Color Seeking Police Intervention During An Intimate Partner Violence Crisis, Michelle Angelica Perez

Walden Dissertations and Doctoral Studies

Exploring the lived experiences of rural women of color in the United States who seek police intervention during an intimate partner violence crisis is a necessity. In rural regions, many African American and Caribbean Blacks in rural communities endure physical assaults perpetrated by their partners throughout their lives. IPV among women of color, especially the obstacles that they face in requesting police intervention. The findings of this research study provide valuable insights that can support the establishment of intervention centers for rural women of color by involving key stakeholders, such as police departments in these regions. This study used semi-structured …

Effective Adapted Psychotherapy Approaches For Autistic Adults: Perspectives From Clinical Psychologists, Emily Morgan Hilton

Walden Dissertations and Doctoral Studies

Autistic adults face a high risk of co-occurring mental health challenges, yet standard psychotherapy often fails to meet their unique needs, raising concerns about treatment effectiveness. This qualitative study aimed to understand how clinical psychologists decide on therapeutic approaches and adaptations for their autistic adult clients through three research questions: RQ1: How do clinical psychologists decide on the appropriate therapeutic approach they use with their autistic adult clients? RQ2: How do clinical psychologists decide which adaptations are appropriate to implement in psychotherapy with their autistic adult clients? RQ3: Does the therapeutic approach affect how a clinical psychologist chooses appropriate adaptations …

The Mediating Role Of Intellectual Humility On The Relationship Between Perspective-Taking And Affective Polarization, Daniel Smith

Walden Dissertations and Doctoral Studies

Affective polarization, a phenomenon characterized by animosity between opposing political parties, has emerged as a growing and intractable problem in the United States. Affective polarization threatens American democracy, as polarized citizens become increasingly unwilling to trust cross-partisans, hold their political leaders accountable, or support the results of free and fair elections. While prior research has investigated the mitigating effect of intellectual humility and perspective-taking on affective polarization, researchers have yet to investigate whether intellectual humility and perspective-taking work synergistically to mitigate affective polarization. Informed by social identity theory, this quantitative study determined if intellectual humility mediated the relationship between perspective-taking …

Optimal Well Being Of Those Recovering From Alcohol Use Disorder: An Exploration Of Individual Difference Factors And Treatment Outcomes, Jared Davis

USF Tampa Graduate Theses and Dissertations

Harmful alcohol use has continued to be one of the largest negative impact factors of daily living worldwide. Despite the pervasive use of alcohol and negative impacts that it has on the individual and society there is large disagreement on how to know when someone has “recovered” from AUD (El-Guebaly, 2012), with much of the literature focused narrowly on negative indicators (e.g., return to heavy drinking, re-occurrence of AUD symptoms). Such views have not only restricted definitions of recovery but has also created public perception that those with AUD will continue to struggle even when cessation of drinking has occurred. …

Real Estate Board Of New York, Inc. V. The City Of New York

All Decisions

The court denied a preliminary injunction against New York City's FARE Act, which shifts broker fee payment from tenants to landlords. The judge granted in part the City's motion to dismiss, striking down plaintiffs' First Amendment, New York State Constitution, and state law preemption claims. However, the Contracts Clause claim was allowed to proceed. The court emphasized that it cannot overturn legislation based on policy disagreements.

Application Of Claims-Based Frailty Index To A Structured Electronic Health Record Data, Min Ji Kwak, Caroline Schaefer, Youngran Kim, Sunyang Fu, Chan Mi Park, Abhijeet Dhoble, Nahid Rianon, Holly M Holmes, Dae Hyun Kim

Faculty, Staff and Student Publications

Background: The Claims-based Frailty Index (CFI) has been developed and validated using Medicare claims data. However, whether CFI can be applied to structured electronic health record data has not been studied.

Methods: We applied the CFI to a structured electronic health record dataset (Explorys dataset) and a Medicare fee-for-service 5% sample data and compared the prevalence of frailty from each dataset, using the cohort of older adults. Then, we assessed the odds ratio and area under the curve of the frailty predicting adverse clinical outcomes, any hospital or emergency room visit, or any adverse drug events related encounter within 1 …

Sickle Cell Disease Induces Chromatin Introversion And Ferroptosis In Cd8+ T Cells To Suppress Anti-Tumor Immunity, Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin

Faculty, Staff and Student Publications

Understanding how genetic disorders affect CD8+ T cells in the tumor microenvironment is key to improving cancer immunotherapy. Individuals with sickle cell disease (SCD), the most prevalent inherited blood disorder, have a higher risk of developing certain cancers than the general population, but the mechanisms driving this increased risk remain unclear. Our study revealed that SCD altered CD8+ T cell 3D genome architecture, triggering ferroptosis and weakening anti-tumor immunity, thereby promoting tumor growth. Using murine and humanized SCD models, we found that disrupted chromosomal interactions in CD8+ T cells reduced the expression of anti-ferroptotic genes, including SLC7A11 and hydrogen sulfide …

Optimized Genomic Editing Of A Common Duchenne Muscular Dystrophy Mutation In Patient-Derived Muscle Cells And A New Humanized Mouse Model, Mateusz Z Durbacz, Yu Zhang, Hui Li, Takahiko Nishiyama, Efrain Sanchez- Ortiz, John R Mcanally, Damir Alzhanov, Ning Liu, Eric N Olson

Faculty, Staff and Student Publications

Duchenne muscular dystrophy (DMD) is a fatal X-linked, recessive disease caused by mutations in the DMD gene encoding dystrophin, a membrane-associated protein necessary for maintaining muscle structure and function. One of the common DMD mutations is the deletion of exon 52 (Δ52), which introduces a premature stop codon in exon 53, preventing the expression of functional dystrophin protein. Patients with this mutation could benefit from skipping or reframing exon 53 to restore the dystrophin open reading frame. In this study, we investigated the efficacy of single-cut CRISPR gene editing with Staphylococcus pyogenes Cas9 (SpCas9)-LRVQR to restore dystrophin expression …

Arid4b: An Orchestrator From Stem Cell Fate To Carcinogenesis, Rakhee Rathnam Kalari Kandy, Madan Kumar Arumugam, Mukesh Pratap Yadav, Bibhuti Bhusan Mishra, Jyotika Sharma

Faculty, Staff and Student Publications

All biological processes, from embryonic development to cancer, are tightly controlled by the interactions between genetics and epigenetics. An array of epigenetic modifications, such as DNA methylation, histone/chromatin modifications, and noncoding RNA-mediated targeting, are essential to regulate the heritable changes that occur during multiple cellular processes. A failure in proper regulation results in inappropriate gene expression that ultimately leads to pathological states. Groundbreaking advances in genomics and transcriptomics have revealed the potential involvement of epigenetics in various physiological and pathological states. The promising clinical and preclinical results shown by epigenetics drugs further underscore the central role of epigenetics in multiple …

Sickle Cell Disease Induces Chromatin Introversion And Ferroptosis In Cd8+ T Cells To Suppress Anti-Tumor Immunity, Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin

Faculty, Staff and Student Publications

Understanding how genetic disorders affect CD8

Virtual Reality’S Impact On Tourist Attitudes In Islamic Religious Tourism: Exploring Emotional Attachment And Vr Presence, Eman Alkhalifah, Ramy Hammady, Mahmoud Abdelrahman, Alyaa Darwish, Ella Cranmer, Ons Al-Shamaileh, Aikaterini Bourazeri, Timothy Jung

All Works

This study explores the integration of immersive technologies, specifically virtual reality (VR), to enhance tourist experiences in the rapidly expanding religious tourism sector. Despite VR’s potential, limited research has examined its impact on religious tourism. This study addresses this gap by investigating the role of emotional attachment in influencing VR presence during pre-, on-site, and postexperiences of VR-mediated religious tourism. A quantitative survey was conducted with 201 respondents who participated in VR religious tourism activities. The empirical analysis, conducted using SPSS and AMOS structural equation modeling (SEM), assessed how VR-mediated religious tourism impacts VR presence and tourist attitudes before actual …

Exploring The Feasibility Of Using Virtual Reality With Children With Autism, Gemma Leighton

Theses and Dissertations

This study explored the feasibility and social validity of teenagers with autism spectrum disorder (ASD) using a virtual reality (VR) head-mounted display (HMD). VR is emerging as a promising tool for teaching and therapeutic intervention among ASD. Therefore, this study serves to contribute to the field's development by comprehensively evaluating the accessibility for young people with ASD to independently using a VR HMD in a meaningful way. Five teenagers participated (four female, aged 13-15, with mild and mild to moderate support needs) and independently completed tutorials in a virtual environment when learning to operate the VR HMD controllers and hand-tracking …

Holistic Student Discipline: How A Proactive Empathetic Approach To Discipline Combined With Restorative Practices Can Change The Discipline Landscape, Melissa A. Dunworth

Education Dissertations

Student discipline in the United States consists of a myriad of methods, including suspension, corporal punishment, isolation, seclusion, and restraint. Since the onset of COVID-19, students and staff have experienced an increase in trauma which has impacted the social-emotional skills of students and teacher burnout. Post-COVID student discipline requires a different approach to discipline combined with restorative practices, which can alter the discipline landscape. This qualitative case study investigates the impact of proactive empathetic discipline and Restorative Practices on student discipline, executive functioning, and school culture.

Grounded in Social Learning Theory, Self-Regulation Theory, and Respect for Children, this study examines …

Re: Comment Letter For Butte Priority Soils Operable Unit (Bpsou) Superfund Operation And Maintenance (O&M) Request For Maintenance – Kelley Stormwater Channels (Dated April 22, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Role Of Autonomic Dysfunction In Initiating Postoperative Atrial Fibrillation In A Canine Sterile Pericarditis Model, Seungyup Lee, Don W. Wallick, Celeen Khrestian, Dragan Juzbasich, Daniel Laurita

Faculty Scholarship

Background: Autonomic dysfunction plays a significant role in initiating postoperative atrial fibrillation (POAF) by causing atrial ectopic triggers, potentially through mechanisms such as increased sympathetic activity and altered vagal tone. These atrial ectopic triggers can easily induce POAF, especially in the presence of vulnerable substrates such as pericardial inflammation or structural remodeling. Objective: To test the hypothesis that autonomic dysfunction causes atrial ectopic triggers or POAF in the canine sterile pericarditis model. Methods: Ten sterile pericarditis dogs were studied on postoperative Days 2−3. Autonomic dysfunction was induced by stellate ganglion nerve stimulation (SNS, 5–15 mA; 4–10 Hz; pulse width 0.5–5 …

Insights Into The Floral Senescence Effects Of Nanoparticles, Vuk Uskoković

Administration and Staff Articles and Research

Flowers could be valuable addenda to nanomedicine labs as in vivo models crossing the gap between the cell culture and small mammals. However, as it is shown here, floral models continue to be predominantly utilized within resource-limited research environments and remain largely underrepresented in mainstream biomedical investigations conducted by well-funded institutions in the developed world. The ability to delay the senescence of Orange Jubilee wildflowers was tested here on three types of nanoparticles: selenite-doped hydroxyapatite (HAp), citrate-stabilized HAp, and superparamagnetic iron oxide. Integration of selenite into the HAp crystal lattice produced a mild increase in the senescence rate …

2025 Hillsborough County Agricultural Fair 4-H Animal Shows, Carrie A. Finke

UNH Cooperative Extension

No abstract provided.

Loss Of Methyltransferase And Hypomethylated M6a Sarcomere Transcripts Leading To Early-Onset Dilated Cardiomyopathy, Sophie Marie Hand, Yi Zhao, Donna Li, Savanna Burke, Hee-Woong Lim, Jessie Yester, Vidu Garg, Federica Accornero, Xiao Li, Deqiang Li, Jihyun Jang

Faculty, Staff and Students Publications

No abstract provided.

Parallel Use Of Low-Complexity Automated Nucleic Acid Amplification Tests And Lateral Flow Urine Lipoarabinomannan Assays To Detect Tuberculosis Disease In Adults And Adolescents Living With Hiv, Stephanie Bjerrum, Bada Yang, Johanna Åhsberg, Laura Olbrich, Mathias Weis Damkjær, Ruvandhi R Nathavitharana, Tobias Broger, Ioana Diana Olaru, Brittney Sweetser, Hayley Poore, Alia Razid, Alexander W Kay, Claudia M Denkinger, Ian Schiller, Nandini Dendukuri, Devan Jaganath, Andreas Lundh, Maunank Shah

Faculty, Staff and Students Publications

Background: Low-complexity automated nucleic acid amplification tests (LC-aNAATs) are molecular World Health Organization (WHO)-recommended rapid diagnostic tests (also known as mWRDs) widely used to diagnose tuberculosis disease. The lateral flow urine lipoarabinomannan assay (LF-LAM) is recommended by the WHO to assist in diagnosing tuberculosis disease amongst people with HIV. Previous systematic reviews have assessed the diagnostic accuracy of LC-aNAATs and LF-LAM used in isolation for the detection of tuberculosis, but in clinical practice the tests may be used in parallel (i.e. LC-aNAAT in combination with LF-LAM).

Objectives: To compare the diagnostic accuracy of the parallel use of LC-aNAAT on respiratory …

Histotripsy: A Novel Non-Invasive Ultrasound Technology For Precision Thrombolysis In Acute Ischemic Stroke Management, Ameer E. Hassan, Thomas Dreyer, Yousef Khalili

School of Medicine Publications

BackgroundStroke remains a major cause of morbidity and mortality worldwide. Traditional treatments for ischemic stroke such as mechanical thrombectomy and pharmacological thrombolysis are often less effective or inaccessible for certain patient populations, particularly those with delayed hospital arrival, contraindications to thrombolytics, or in regions with limited access to endovascular care. This study investigates the feasibility of using histotripsy, a non-invasive ultrasound technology, to precisely liquefy thrombi in an artificial experimental setup.MethodsClot analogs were introduced into sample tubes, and focused ultrasound was applied using optimized parameters, including pulses per burst, repetition rates, and output amplitudes. These parameters were systematically adjusted to …