Digital Commons Network^™

Arid4b: An Orchestrator From Stem Cell Fate To Carcinogenesis, Rakhee Rathnam Kalari Kandy, Madan Kumar Arumugam, Mukesh Pratap Yadav, Bibhuti Bhusan Mishra, Jyotika Sharma

Faculty, Staff and Student Publications

All biological processes, from embryonic development to cancer, are tightly controlled by the interactions between genetics and epigenetics. An array of epigenetic modifications, such as DNA methylation, histone/chromatin modifications, and noncoding RNA-mediated targeting, are essential to regulate the heritable changes that occur during multiple cellular processes. A failure in proper regulation results in inappropriate gene expression that ultimately leads to pathological states. Groundbreaking advances in genomics and transcriptomics have revealed the potential involvement of epigenetics in various physiological and pathological states. The promising clinical and preclinical results shown by epigenetics drugs further underscore the central role of epigenetics in multiple …

Sickle Cell Disease Induces Chromatin Introversion And Ferroptosis In Cd8+ T Cells To Suppress Anti-Tumor Immunity, Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin

Faculty, Staff and Student Publications

Understanding how genetic disorders affect CD8

Virtual Reality’S Impact On Tourist Attitudes In Islamic Religious Tourism: Exploring Emotional Attachment And Vr Presence, Eman Alkhalifah, Ramy Hammady, Mahmoud Abdelrahman, Alyaa Darwish, Ella Cranmer, Ons Al-Shamaileh, Aikaterini Bourazeri, Timothy Jung

All Works

This study explores the integration of immersive technologies, specifically virtual reality (VR), to enhance tourist experiences in the rapidly expanding religious tourism sector. Despite VR’s potential, limited research has examined its impact on religious tourism. This study addresses this gap by investigating the role of emotional attachment in influencing VR presence during pre-, on-site, and postexperiences of VR-mediated religious tourism. A quantitative survey was conducted with 201 respondents who participated in VR religious tourism activities. The empirical analysis, conducted using SPSS and AMOS structural equation modeling (SEM), assessed how VR-mediated religious tourism impacts VR presence and tourist attitudes before actual …

Exploring The Feasibility Of Using Virtual Reality With Children With Autism, Gemma Leighton

Theses and Dissertations

This study explored the feasibility and social validity of teenagers with autism spectrum disorder (ASD) using a virtual reality (VR) head-mounted display (HMD). VR is emerging as a promising tool for teaching and therapeutic intervention among ASD. Therefore, this study serves to contribute to the field's development by comprehensively evaluating the accessibility for young people with ASD to independently using a VR HMD in a meaningful way. Five teenagers participated (four female, aged 13-15, with mild and mild to moderate support needs) and independently completed tutorials in a virtual environment when learning to operate the VR HMD controllers and hand-tracking …

Holistic Student Discipline: How A Proactive Empathetic Approach To Discipline Combined With Restorative Practices Can Change The Discipline Landscape, Melissa A. Dunworth

Education Dissertations

Student discipline in the United States consists of a myriad of methods, including suspension, corporal punishment, isolation, seclusion, and restraint. Since the onset of COVID-19, students and staff have experienced an increase in trauma which has impacted the social-emotional skills of students and teacher burnout. Post-COVID student discipline requires a different approach to discipline combined with restorative practices, which can alter the discipline landscape. This qualitative case study investigates the impact of proactive empathetic discipline and Restorative Practices on student discipline, executive functioning, and school culture.

Grounded in Social Learning Theory, Self-Regulation Theory, and Respect for Children, this study examines …

Re: Comment Letter For Butte Priority Soils Operable Unit (Bpsou) Superfund Operation And Maintenance (O&M) Request For Maintenance – Kelley Stormwater Channels (Dated April 22, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Role Of Autonomic Dysfunction In Initiating Postoperative Atrial Fibrillation In A Canine Sterile Pericarditis Model, Seungyup Lee, Don W. Wallick, Celeen Khrestian, Dragan Juzbasich, Daniel Laurita

Faculty Scholarship

Background: Autonomic dysfunction plays a significant role in initiating postoperative atrial fibrillation (POAF) by causing atrial ectopic triggers, potentially through mechanisms such as increased sympathetic activity and altered vagal tone. These atrial ectopic triggers can easily induce POAF, especially in the presence of vulnerable substrates such as pericardial inflammation or structural remodeling. Objective: To test the hypothesis that autonomic dysfunction causes atrial ectopic triggers or POAF in the canine sterile pericarditis model. Methods: Ten sterile pericarditis dogs were studied on postoperative Days 2−3. Autonomic dysfunction was induced by stellate ganglion nerve stimulation (SNS, 5–15 mA; 4–10 Hz; pulse width 0.5–5 …

Insights Into The Floral Senescence Effects Of Nanoparticles, Vuk Uskoković

Administration and Staff Articles and Research

Flowers could be valuable addenda to nanomedicine labs as in vivo models crossing the gap between the cell culture and small mammals. However, as it is shown here, floral models continue to be predominantly utilized within resource-limited research environments and remain largely underrepresented in mainstream biomedical investigations conducted by well-funded institutions in the developed world. The ability to delay the senescence of Orange Jubilee wildflowers was tested here on three types of nanoparticles: selenite-doped hydroxyapatite (HAp), citrate-stabilized HAp, and superparamagnetic iron oxide. Integration of selenite into the HAp crystal lattice produced a mild increase in the senescence rate …

2025 Hillsborough County Agricultural Fair 4-H Animal Shows, Carrie A. Finke

UNH Cooperative Extension

No abstract provided.

Loss Of Methyltransferase And Hypomethylated M6a Sarcomere Transcripts Leading To Early-Onset Dilated Cardiomyopathy, Sophie Marie Hand, Yi Zhao, Donna Li, Savanna Burke, Hee-Woong Lim, Jessie Yester, Vidu Garg, Federica Accornero, Xiao Li, Deqiang Li, Jihyun Jang

Faculty, Staff and Students Publications

No abstract provided.

Parallel Use Of Low-Complexity Automated Nucleic Acid Amplification Tests And Lateral Flow Urine Lipoarabinomannan Assays To Detect Tuberculosis Disease In Adults And Adolescents Living With Hiv, Stephanie Bjerrum, Bada Yang, Johanna Åhsberg, Laura Olbrich, Mathias Weis Damkjær, Ruvandhi R Nathavitharana, Tobias Broger, Ioana Diana Olaru, Brittney Sweetser, Hayley Poore, Alia Razid, Alexander W Kay, Claudia M Denkinger, Ian Schiller, Nandini Dendukuri, Devan Jaganath, Andreas Lundh, Maunank Shah

Faculty, Staff and Students Publications

Background: Low-complexity automated nucleic acid amplification tests (LC-aNAATs) are molecular World Health Organization (WHO)-recommended rapid diagnostic tests (also known as mWRDs) widely used to diagnose tuberculosis disease. The lateral flow urine lipoarabinomannan assay (LF-LAM) is recommended by the WHO to assist in diagnosing tuberculosis disease amongst people with HIV. Previous systematic reviews have assessed the diagnostic accuracy of LC-aNAATs and LF-LAM used in isolation for the detection of tuberculosis, but in clinical practice the tests may be used in parallel (i.e. LC-aNAAT in combination with LF-LAM).

Objectives: To compare the diagnostic accuracy of the parallel use of LC-aNAAT on respiratory …

Histotripsy: A Novel Non-Invasive Ultrasound Technology For Precision Thrombolysis In Acute Ischemic Stroke Management, Ameer E. Hassan, Thomas Dreyer, Yousef Khalili

School of Medicine Publications

BackgroundStroke remains a major cause of morbidity and mortality worldwide. Traditional treatments for ischemic stroke such as mechanical thrombectomy and pharmacological thrombolysis are often less effective or inaccessible for certain patient populations, particularly those with delayed hospital arrival, contraindications to thrombolytics, or in regions with limited access to endovascular care. This study investigates the feasibility of using histotripsy, a non-invasive ultrasound technology, to precisely liquefy thrombi in an artificial experimental setup.MethodsClot analogs were introduced into sample tubes, and focused ultrasound was applied using optimized parameters, including pulses per burst, repetition rates, and output amplitudes. These parameters were systematically adjusted to …

Exposure-Response Relationship Of Household Air Pollution On Body Mass Index Among Women In Rural Areas Of Guatemala, India, Peru And Rwanda: Household Air Pollution Intervention Network Trial, Adolphe Ndikubwimana, Lisa De Las Fuentes, Victor G Dávila-Román, Et Al.

2020-Current year OA Pubs

BACKGROUND: Household air pollution from burning biomass materials, the main cooking fuel in low- and middle-income countries, may be linked to metabolic dysfunction. We assessed cross-sectional associations between household air pollution and body mass index (BMI), expecting to see increased BMI with higher pollution concentrations.

METHODS: We analyzed data from 414 women aged 40 to 79 years who resided in the households using biomass fuel and were enrolled in the multi-country Household Air Pollution Intervention Network (HAPIN) Trial. We explored associations of 24-h average personal exposure to fine particulate matter (PM

RESULTS: We observed mixed evidence of associations between household …

Symbiotic International Law: Combatting Uyghur Forced Labor, Preston Jordan Lim

Faculty Publications

Since 2017, the Chinese government has launched a campaign of repression against the Muslim Turkic minorities of Xinjiang, a region located in China’s Northwest. While most scholars have focused on the mass internment of Uyghurs and other minorities, this Article highlights an under-discussed aspect of China’s campaign: the construction of a sophisticated forced labor system. Minority forced labor supplies key sectors of the global economy—from the automotive to the energy sectors—and allows Chinese companies to outcompete foreign firms. The unprecedented scope and sophistication of what I term the “modern Xinjiang forced labor system” imperils the very future of the international …

Middle Meningeal Artery Embolization For Chronic Subdural Hematoma: Meta-Analysis Of Three Randomized Controlled Trials And Review Of Ongoing Trials., Gillespie Cs, M Veremu, Cook Wh, M Ashraf, Lee Ks, Y Chedid, Alam Am, Y Karepov, Davies Bm, E Edlmann, P Papanagiotou, S Korfias, T Santarius, A Kolias

Peninsula Medical School

Background: Middle Meningeal Artery Embolization (MMAE) has been proposed as adjunct and stand-alone treatment for Chronic Subdural Hematoma (CSDH). We aimed to meta-analyze three recently published randomized controlled trials, to reliably estimate the effect of MMAE. We also carried out a systematic review of ongoing trials and their key outcomes. Methods: A PRISMA-compliant meta-analysis was conducted (PROSPERO ID CRD42024618816). Three published RCTs (MAGIC-MT, EMBOLISE, and STEM) assessing MMAE in CSDH were included. Trial primary outcomes were pooled for analysis using random effects models. Primary and secondary outcomes (recurrence/surgical rescue, functional outcome) were obtained, stratified by treatment group (undergoing surgery, and …

Structure-Function Coupling In The First Month Of Life: Associations With Age And Attention, Ursula A Tooley, Jeanette K Kenley, M Catalina Camacho, Aidan Latham, Dimitrios Alexopoulos, Ashley N Nielsen, Tara A Smyser, Barbara B Warner, Joshua S Shimony, Jeffrey J Neil, Joan L Luby, Deanna M Barch, Cynthia E Rogers, Christopher D Smyser

2020-Current year OA Pubs

How brain structure relates to function is a critical and open question in neuroscience. Here, we characterize regional variation in structure-function coupling, capturing the degree to which a cortical region's structural connections relate to patterns of coordinated neural activity in healthy, term-born neonates (

High Prevalence Of Co-Infections With Latent Tuberculosis, Syphilis And Hepatitis B And C Among People With Hiv In Ghana: A Call For Integrating Screening Into Routine Care, Helena Lamptey, James Odame Aboagye, Christopher Zaab-Yen Abana, Anthony Twumasi Boateng, Ephraim Mawufemor Kofi Kanda, Dzidzor Aku Attoh, Araba Abaidoo-Myles, Charlotte Borteley Bortey, Jonathan Klutse, Peter Puplampu, Gloria Ansa, Vincent Jessey Ganu, Joseph Oliver-Commey, Evelyn Yayra Bonney, George Boateng Kyei

2020-Current year OA Pubs

BACKGROUND: People with HIV (PWH) are at risk of co-infections, such as latent tuberculosis (LTBI), hepatitis B (HBV), hepatitis C (HCV), and syphilis; hence, routine screening is critical. However, evaluation of routine screening is not being fully implemented in Ghana. This study assessed the prevalence of these co-infections among PWH in Accra, Ghana.

METHODS: The HIV Cure Research Infrastructure Study (H-CRIS) followed 390 PWH from three HIV treatment centres in Accra. A cross-sectional study was conducted within this cohort, and participants were screened for LTBI, hepatitis B, hepatitis C, and syphilis using standardized assays. LTBI was detected using the QuantiFERON-TB …

A Library Of Lineage-Specific Driver Lines Connects Developing Neuronal Circuits To Behavior In The Drosophila Ventral Nerve Cord, Jelly H M Soffers, Erin Beck, Daniel J Sytkowski, Marianne E Maughan, Devasri Devarakonda, Yi Zhu, Beth A Wilson, Yu-Chieh David Chen, Ted Erclik, James W Truman, James B Skeath, Haluk Lacin

2020-Current year OA Pubs

Understanding developmental changes in neuronal lineages is crucial to elucidate how they assemble into functional neural networks. Studies investigating nervous system development in model systems have only focused on select regions of the CNS due to the limited availability of genetic drivers that target specific neuronal lineages throughout development and adult life. This has hindered our understanding of how distinct neuronal lineages interconnect to form neuronal circuits during development. Here, we present a split-GAL4 library composed of genetic driver lines, which we generated via editing the genomic locus of lineage-specific transcription factors and demonstrate that we can use this library …

Impact Of Vein-To-Vein Time In Patients With R/R Lbcl Treated With Axicabtagene Ciloleucel, Frederick L Locke, Armin Ghobadi, Et Al.

2020-Current year OA Pubs

Chimeric antigen receptor (CAR) T-cell products axicabtagene ciloleucel (axi-cel), tisagenlecleucel (tisa-cel), and lisocabtagene maraleucel (liso-cel) are approved for relapsed/refractory (R/R) large B-cell lymphoma (LBCL). Emerging evidence indicates that delayed CAR T-cell infusion, including prolonged time from leukapheresis to infusion, known as vein-to-vein time (V2Vt), may adversely impact clinical outcomes. We conducted a systematic literature review (SLR) and meta-analysis to identify differences in V2Vt in patients with R/R LBCL treated with axi-cel, tisa-cel, or liso-cel. The impact of V2Vt (< 28 days vs ≥28 to < 40 days vs ≥40 days) on effectiveness and safety outcomes was evaluated in patients treated with axi-cel enrolled in a post-authorization safety study using the Center for International Blood and Marrow Transplant Research data. SLR and meta-analysis showed that patients treated with axi-cel had the shortest median V2Vt (30.6 days) compared with tisa-cel (48.4 days) or liso-cel (35.9 days). Real-world analysis of patients treated with axi-cel demonstrated that V2Vt ≥40 days was associated with significantly lower complete response rate than V2Vt < 28 days (odds ratio [OR], 0.61) or ≥28 to < 40 days (OR, 0.66) and significantly worse overall survival than V2Vt < 28 days (hazard ratio [HR], 1.33) or ≥28 to < 40 days (HR, 1.36). Higher prolonged thrombocytopenia rates were observed in patients with axi-cel V2Vt ≥28 to < 40 days or ≥40 days compared with < 28 days (OR, 1.44 or 1.95, respectively). Together, these results show the impact of V2Vt on patient outcomes with axi-cel therapy and that earlier infusion with CD19-CAR therapies may be beneficial.

Source-Specific Nitrate And Nitrite Intake And Association With Colorectal Cancer In The Danish Diet, Cancer And Health Cohort, Dorit W. Erichsen, Nicola P. Bondonno, Pratik R. Pokharel, Susanne M. Rosthoj, Catherine P. Bondonno, Liezhou M. Zhong, Jorg Schullehner, Torben L. Sigsgaard, Peter Fjeldstad Hendriksen, Frederik Dalgaard, Ole Raaschou-Nielsen, Jonathan M. Hodgson, Christina C. Dahm, Anja Olsen, Anne Tjonneland, Cecilie Kyro

Research outputs 2022 to 2026

Introduction: Nitrate and nitrite, present in food and drinking water, may contribute to colorectal cancer (CRC) through the formation of carcinogenic N-nitroso compounds (NOCs). This study examined source-specific associations with CRC and subtypes, considering potential dietary and lifestyle factors that influence NOC formation. Methods: In the Danish Diet, Cancer, and Health Cohort (N=54,610), nitrate/nitrite intake was estimated from comprehensive databases and national monitoring data. Over 27 years, 2245 CRC cases (1508 colon and 737 rectal) were identified via the Danish Cancer Registry. Cox proportional hazards models adjusted for sociodemographic, diet, and lifestyle factors were used to examine associations, with stratified …

The Impact Of Blue Economy Factors On Morocco's Economic Growth, Lqamar Youssef, El Amine Youness Mr, Smouni Rachid Pr

Journal of Ocean and Coastal Economics

Purpose - This study examines the influence of blue economy factors on Morocco's economic growth.

Design/methodology/ approach - Using secondary data from 1980 to 2022, the analysis focuses on fishery production and its various sectors as contributing factors to economic growth. The study employs the Autoregressive Distributed Lag (ARDL) method and aims to highlight the impact of deep-sea fishing and coastal fishing in the context of a transition to a sustainable and inclusive blue economy.

Findings - The results suggest that coastal fishing has more potential for creating inclusive economic value within the development of the blue economy, thus promoting …

Geoxo Ocx Prelaunch And On-Orbit Calibration, Alexandra Ocasio, Lauren Aycock, Sandra Collins, Meghan Knudtzon

The Characterization and Radiometric Calibration for Remote Sensing Annual Meeting (CALCON)

BAE will build the Ocean Color (OCX) instrument for NOAA’s next-generation Geostationary Extended Observations (GeoXO) satellite network. The OCX design provides high spatial resolution, moderate spectral resolution, high radiometric sensitivity, and calibration accuracy data at an unprecedented area collection rate to enable significant advances in Ocean Color science. This presentation addresses the OCX prelaunch and on-board calibration approach that will provide hyperspectral measurements with high absolute radiometric accuracy and stability.

Innovation Highlight - Human Trafficking And Disability, Elizabeth Bowman Phd

SMU Human Trafficking Data Conference

No abstract provided.

Evaluating The Physiological Effects Of A Spacesuit While Performing Cpr, Marielle Lenehan

Beyond: Undergraduate Research Journal

Limited research exists on the challenges of performing cardiopulmonary resuscitation (CPR) while wearing a spacesuit/pressure suit; but, during a space mission or following spacecraft egress, astronauts may need to perform Basic Life Support (BLS) on a crewmember. BLS consists of CPR and External Chest Compressions (ECC). In an emergency, astronauts may not have time to remove their intravehicular (IVA) spacesuits/pressure suits or wait for their heart rates to return to resting conditions and, therefore, would have to perform CPR while physically exerted. This study sought to evaluate the physiological exertion on rescuer performance while performing ECCs over 6 minutes while …

The Biblical Foundations Of Conservation Biology, Aaron G. Corbit Phd

The Journal of Biblical Foundations of Faith and Learning

The purpose of this essay is to contextualize the biological discipline of conservation biology within the Seventh-day Adventist Biblical worldview. It does so by evaluating, from a Biblical perspective, the four “normative postulates” of the discipline that were advanced by one of the fathers of modern conservation biology, Michael E. Soulé. Soulé’s normative postulates were that 1) Diversity of organisms is good, 2) Ecological complexity is good, 3) Evolution is good, and 4) Biotic diversity has intrinsic value. I will argue that the Bible affirms Soulé’s first two postulates because the account of creation in Genesis affirms that God created …

Benefits Of A Faculty Mentored Personalized Instructional Program For Dental Students, Terry E. Hoover, Parvati H. Iyer Dr.

Pacific Journal of Health

The rigors and focus required of dental education often leaves students without time to pursue in-depth learning experiences in areas of personal interest related to dentistry/healthcare. In response to student interest in such learning and enrichment opportunities, a Personalized Instructional Program (PIP) course was created at the Arthur A. Dugoni School of Dentistry to allow students to engage in a faculty-mentored experiential learning project of their own creation. With its already condensed three-year curriculum, there was initial concern at Pacific Dugoni about whether an additional self-regulated experience could fit into students’ already busy schedules. Thirty hours of curricular time was …

A Participatory Approach To Case Management: Co-Creation Of Effective Anti-Trafficking Programming Based On The Self-Identified Strengths, Needs, And Priorities Of Survivors, Angela Robinson Phd, Kelsey Morgan Phd

SMU Human Trafficking Data Conference

Some estimates claim the existence of 50 million victims of human trafficking and the U.S. Department of State suggests that less than 1% of survivors received services to prevent further exploitation. This presentation shares processes for co-creating knowledge with case management tools that empower survivors while gathering data to improve their care, assist service providers in effectively targeting supportive services, and strengthen anti-trafficking initiatives. Findings will be shared from Freedom Lifemap, a self-assessment used by human trafficking survivors to identity their own strengths, needs, and priorities to prevent the risk of re-exploitation and attain lasting freedom. Global patterns in data …

Effects Of Elevated Temperatures On Tooth Structure During Polymerization Of Composite Resin With A Variety Of Light Sources, Enas G. Yonis

Al-Bahir

This study investigated the impact of high temperatures on dental tissues during the polymerization of optical fillings using a diode laser and two types of pulsed and continuous LED devices. Three distinct light source units were employed: a laser diode, an LEDition, and a LED.B. Temperature increases were measured at a distance of 1 mm from the thermocouple to the tip of the device. To create an experimental model, we fixed the operational voltage of the polymerization device and maintained a 1 mm gap between the terminal and the thermocouple wire. Temperature readings and thermal background (TO) measurements were taken …

The Rhetoric Of Responsibilization: A Rhetorical Analysis Of Pre-Exposure Prophylaxis Campaigns For Hiv Prevention, Catherine M. Pabalate

Kentucky Undergraduate Journal for the Health Humanities

Responsibilization refers to the process by which patients are made accountable for their health and wellbeing, which is determined by their habits and behaviors. Though responsibilization affords greater agency to patients, it can also result in anxiety and guilt when the patient appears "deviant" or "noncompliant." Because sexual behavior is attributed to the causality of HIV/AIDS, patients’ sexual patterns and choices are included within their medical decision-making. This rhetorical analysis focuses on pharmaceutical campaigns and commercials for pre-exposure prophylaxis (PrEP), which were released between 2012 and 2024 and are targeted towards patients at-risk for HIV/AIDS. Findings suggest that specific rhetorical …

Across Generations Of Time: Institutional Memory And Individual Memory Of The Kwangju Uprising Regarding The Hong Family, Seung Hong

Undergraduate Honors Theses

On May 18, 1980, the Kwangju Uprising took place in Kwangju, a city in the Chŏlla province of South Korea. Though it was initially a student demonstration against Chun Doo Hwan’s martial law, it grew to involve thousands of Kwangju civilians who united to fight against vicious paratroopers and Chun’s unjust rule. After nine days, state troops recaptured Kwangju and arrested the remaining demonstrators. Years later, as a response to popular demand, the South Korean government compensated victims and began celebrating May 18 as a turning point for democracy in the nation. The institutional memory of the Kwangju Uprising has …