Digital Commons Network^™

High-Salt Tumor Microenvironment: Not As Bad As It Sounds, Not As Good As It Seems, Umer Ali, Venkataswarup Tiriveedhi

Biology Faculty Research

Recent evidence suggests a high-sodium microenvironment in breast tumors. However, the exact role of this high-sodium microenvironment on tumorigenesis is unknown. Salt (sodium chloride, NaCl) is a well-known inflammatory molecule playing a significant role in various chronic ailments like cardiovascular and autoimmune diseases. Importantly, chronic inflammation is recognized as one of the major hallmarks of carcinogenesis. Breast cancer cell culture-based studies demonstrated that high-salt (HS) treatment (Δ35–50 mM NaCl) induced cancer cell proliferation. However, preclinical murine research showed reduced tumor progression kinetics in mice fed a short-term HS diet (4% NaCl diet, 0–2 weeks prior to the injection of tumor …

Improving Health Outcomes For Elderly Patients With Post-Stroke Depression: A Staff Education Project For Implementing A Collaborative Care Model In A Connecticut Behavioral Health Facility, Nneka Mcclane

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) project is a staff education program aimed at improving nursing care for elderly patients with post-stroke depression (PSD) through education on the collaborative care model (CCM). The practice concern addressed is the underrecognition and undertreatment of PSD in elderly patients in a rehabilitation setting due to a lack of staff knowledge and confidence in screening for PSD in the elderly. The aim of this DNP project was to provide staff with the knowledge necessary to engage PSD screening as a part of the CCM, which has the potential to enhance PSD management and improve …

Jean Prillman V. George Parsons

2025 Decisions

USDC for the Eastern District of Pennsylvania

Daniel Andrews,Sr. V. Pennsylvania Department Of Corrections

2025 Decisions

USDC for the Middle District of Pennsylvania

The Efficacy Of Open Educational Resources On Achievement Outcomes In Different Higher Education Institutions, Angela Grace Findlay

Theses and Dissertations

Students suffer from achievement gaps in higher education. Achievement gaps refer to differences in graduation rates, retention rates, persistence rates, and student's grades. Achievement gaps may negatively affect students who are culturally or ethnically diverse and/or have a lower socioeconomic status. The use of open educational resources (OER) may mitigate achievement gaps as OER assists student success through higher academic performance and cost savings for students. Average quiz scores were obtained at different higher education institutions using an Introduction to Psychology OER. The scores from each course were analyzed using hierarchical linear modeling. Colleges were nested by demographics to evaluate …

June 2025 General Education Council Minutes, University Of Nebraska At Kearney General Education Council

General Education Council

No abstract provided.

Measuring What Matters To Patients: A Multiple Methods Sequential Study Of Disease Burden, Quality Of Life, And The Alignment Of Patient-Reported Outcome Measurements For High-Risk Myelodysplastic Syndrome And Acute Myelogenous Leukemia Patients, Anthony J. Messina

Doctor of Philosophy in Translational Health Sciences Dissertations

Background

High-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are aggressive hematologic malignancies with poor prognoses, where extending survival often comes at the cost of substantial morbidity. This study was grounded in the quality of survival (QoS) framework, which emphasizes that treatment outcomes should balance longevity with the health-related quality of life (HRQoL) experienced during the period of survival. In this context, patient-reported outcomes are crucial to capturing what truly matters to patients. However, existing patient-reported outcome measures (PROMs) used in MDS/AML clinical trials may not fully reflect patient priorities. A complementary Wilson–Cleary model perspective, linking biological factors to …

Accessible And Inclusive Pathways To Higher Education: Outcomes From A Pilot Feasibility Study Of Irish Transition-Year Student Participation With University Pre-College Courses, Susan Lynott, Charlie Cullen, Kevin Mellon

Irish Journal of Academic Practice

The TYDE programme is a college-in-school initiative which aims to develop partnerships between Technological University Dublin (TU Dublin) and local schools. It provides second-level students with an authentic experience of what is required to succeed in university programmes within the familiar environment of school. This experience supports students in transitioning from secondary school to university life, encourages participation, and supports good college and career choices. Transition-year students (15–16 year-olds) take core university modules from engineering programmes running at TU Dublin. The students get to experience first-year modules under the same conditions as college students. In this paper we present the …

Report On 2024-2025 Compliance With Continuous Quality Improvement Legislation, University Of Northern Iowa

Institutional Effectiveness & Planning Documents

A report provided to the Iowa Board of Regents regarding continuous improvement processes in courses at the University of Northern Iowa.

Human Gut Commensal Alistipes Timonensis Modulates The Host Lipidome And Delivers Anti-Inflammatory Outer Membrane Vesicles To Suppress Colitis In An Il10-Deficient Mouse Model, Ethan Older, Mary K. Mitchell, Andrew Campbell, Xiaoying Lian, Michael Madden, Yuzhen Wang, Lauren E. Van De Wal, Thelma Zaw, Brandon N. Vanderveen, Rodney Tatum, E. Angela Murphy, Yan-Hua Chen, Daping Fang, Melissa Ellermann, Jie Li

Faculty Publications

Correlative studies have linked human gut microbes to specific health conditions. Alistipes is one such microbial genus negatively linked to inflammatory bowel disease (IBD). However, the protective role of Alistipes in IBD is understudied, and the underlying molecular mechanisms remain unknown. In this study, colonization of Il10-deficient mice with Alistipes timonensis DSM 27924 delays colitis development. Colonization does not significantly alter the gut microbiome composition, but instead shifts the host plasma lipidome, increasing phosphatidic acids while decreasing triglycerides. Outer membrane vesicles (OMVs) derived from Alistipes are detected in the plasma of colonized mice, carrying potentially immunomodulatory metabolites into the …

June 10, 2025 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

A Challenging Case Of Pyruvate Kinase Deficiency Complicated By Hemophagocytic Lymphohistiocytosis, Christopher Pope, Farah Ashraf, Jacqueline White, Akhilesh Sivakumar, Eric Behling, Tulin Budak-Alpdogan

Cooper Rowan Medical Journal

Pyruvate kinase deficiency (PKD) is an autosomal recessive disorder and the most common cause of chronic hemolytic anemia secondary to red blood cell (RBC) enzyme defects. Treatment is mainly supportive including splenectomy and transfusions. Mitapivat, an oral allosteric activator of defective pyruvate kinase, was approved by the FDA in February 2022 for treatment of adults with PKD. However, because Mitapivat undergoes liver metabolism, patients must have stable liver profiles prior to initiation of therapy. We present a case of PKD complicated by hemophagocytic lymphohistiocytosis (HLH). We initiated steroid therapy for his HLH with the intent to subsequently start Mitapivat. We …

Hollow Choices: The Choice Neighborhood Initiative (Cni) And The Performance Of Participation, Lena Kufferman

Geography Undergraduate Senior Theses

Since HUD Secretary Henry Cisneros' pledge in 1995 to “end public housing as we know it, ” the United States has seen the rapid depletion of public housing stock. Alongside this mass demolition, a new redevelopment paradigm emerged: a community-oriented planning model that requires resident participation. HUD’ s shift toward participatory planning began with HOPE VI in 1992, which sought private investment to demolish public housing, and was formalized in 2010 through the Choice Neighborhoods Initiative (CNI). This thesis examines a CNI planning phase—a stage overlooked in existing scholarship, which largely stresses post-occupancy outcomes like displacement, (im)mobility, socioeconomic integration, and …

Adolescent Preventive Care Outcomes Before And After Covid-19 Onset: What Is The Role Of Telehealth?, Sarah Hayden Knipper

Dissertations and Theses

Adolescents are a developmentally distinctive population with unique primary health care needs; they comprise about 10% of Oregon's population and more than half are covered by the Oregon Health Plan (OHP). This dissertation investigated significant declines in preventive care utilization (well visits and HPV immunizations) among adolescents enrolled in OHP during the COVID-19 pandemic and the relationship between the decline in utilization and the rise in telehealth availability. The study focused specifically on the role of race/ethnicity, geography, and access to health systems in mitigating or exacerbating decreases in preventive care. A mixed methods approach was employed to understand not …

A Fifty-Year Assessment Of Historical Planning Processes And Green Space Distribution (1975-2025): A Case Study Of Portland, Or, Usa, Quadri Olatunbosun Taiwo

Dissertations and Theses

The Portland study examined past planning regulations and greenspace distribution over the period of fifty years, with particular attention given to neighborhood differences between invested and non-invested neighborhoods. This research utilized a mixed-methods approach through the synthesis of qualitative themes from oral narratives and archival records. Furthermore, I examined spatial greenspace using Normalized Difference Vegetation Index (NDVI) imagery. I tested the study hypothesis using the GIS Ordinary Least Squares (OLS) regression test to predict how key sociodemographic characteristics affect the provision of greenspace in non-white disinvested neighborhoods. The key findings indicated a consistent trend of inequity in greenspace, heavily shaped …

Family Leadership Council Invests In Student Experience, Tina H. Hahn

University of Mississippi News

OXFORD, Miss. – The Ole Miss Family Leadership Council has invested more than $400,000 in the University of Mississippi to strengthen the student experience. The projects will help students maintain their physical and mental health, access career development resources and thrive even when facing financial challenges.

Hematopoietic Stem Cell Transplantation Outcomes For High-Risk Aml: A Report From The Children's Oncology Group., Benjamin J. Huang, Lauren K. Meyer, Todd A. Alonzo, Yi-Cheng Wang, Adam J. Lamble, Rhonda E. Ries, Weijie Wang, Betsy Hirsch, Gordana Raca, Xiaotu Ma, Alan S. Gamis, Richard Aplenc, E Anders Kolb, Todd M. Cooper, Katherine Tarlock, Michael R. Loken, Soheil Meshinchi, Joseph H. Chewning, William G. Woods, John T. Horan

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: Hematopoietic stem cell transplantation (HSCT) is used as consolidation for pediatric patients with high-risk AML in first complete remission (CR1). The definition of high-risk AML has evolved considerably over the past two decades with the successive identification of new unfavorable risk factors. We conducted a cross-study analysis to determine whether HSCT improves the outcomes of patients with contemporarily defined high-risk AML.

METHODS: We combined data from AAML0531 and AAML1031, the last two phase III clinical trials completed by the Children's Oncology Group (COG). These two trials established the prognostic importance of measurable residual disease (MRD) and several high-risk cryptic …

Real-World Outcomes For Young Adult Patients Receiving Cd19 Car T-Cell Therapy., Hannah Lust, Liora M. Schultz, Soyang Kwon, Gregory W. Roloff, Ibrahim Aldoss, Christina Baggott, Samuel John, Jenna E. Rossoff, Kevin O. Mcnerney, Vanessa A. Fabrizio, Julie-An Talano, Amy Moskop, Kevin J. Curran, Christine L. Phillips, Nicole Karras, Susanne H C Baumeister, Stacy L. Cooper, Michelle Hermiston, Prakash Satwani, Muna Qayed, Sunil S. Raikar, Margaret Macmillan, Erin Hall, Khanh Nguyen, Ryan D. Cassaday, Noam E. Kopmar, Vamsi K. Kota, John Mathews, Paul Shaughnessy, Marc S. Schwartz, Abdullah Ladha, George Yaghmour, Muthu V. Kumaran, Veronika Bachanova, Sean Tracy, Tamer Othman, Marlise R. Luskin, Evan C. Chen, Anjani S. Advani, Nikeshan Jeyakumar, Katharine Miller, Amy Zhang, Katherine C. Sutherland, Bijal D. Shah, Lori Muffly, Rawan Faramand

Manuscripts, Articles, Book Chapters and Other Papers

Tisagenlecleucel (tisa-cel) and brexucabtagene autoleucel (brexu-cel) are approved CD19 chimeric antigen receptor T-cell therapy (CAR T) products for young adults (YA) with relapsed/refractory B-cell acute lymphoblastic leukemia. A distinct analysis of YAs receiving commercial CD19 CAR T has not been reported. Using retrospective data from the Pediatric Real-World CAR T Consortium and the Real-World Outcomes of CAR T in Adult ALL collaboration, we describe the efficacy and safety of tisa-cel and brexu-cel in 70 YAs (18-26 years; tisa-cel, n = 50; brexu-cel, n = 20). Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) were observed more frequently …

Status Epilepticus Protocol Variation Across Accredited National Association Of Epilepsy Centers Members., Laura K. Lamberta, Melissa Asmar, Megan M. Fredwall, Stephanie M. Ahrens, Shasha Bai, Mariah Eisner, Fred Alexander Lado, Stephan U. Schuele, Dave F. Clarke, Ahmed Abdelmoity, Kathryn A. Davis, Jennifer L. Hopp, Mohamad Z. Koubeissi, Meriem K. Bensalem Owen, Susan T. Herman, Adam P. Ostendorf, Naec Center Director Study Group

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: Status epilepticus (SE) is a neurologic emergency that requires urgent recognition and medical management. SE management remains heterogeneous across centers.

METHODS: We analyzed SE treatment protocols from level 3 and level 4 epilepsy centers. Discrete data including stabilization measures, timing of treatment phases, medications, doses, and routes of administration were collected from each protocol and described using frequency for categorical variables and median for continuous variables. The distribution of treatment times and dosing were compared with the AES guideline.

RESULTS: A total of 256 SE treatment protocols were included. Only 66% of SE protocols detailed treatment times. Doses below …

Redeeming The Amazon: Development Discourses And Imaginaries In Manaus, Brazil, Beatriz Da Silva Falcao

Geography Undergraduate Senior Theses

In 1957, the Brazilian government approved Law No.1310, establishing a free port in the city of Manaus, the capital of the state of Amazonas. Politicians at the time argued that such a project was essential to help mitigate the unfortunate economic circumstances the state faced due to its geographical isolation. Ten years later, the military dictatorship that ruled Brazil expanded that mission through Decree No.288, thus creating what is now known as the Zona Franca de Manaus (ZFM, Free Trade Zone, or FTZ), an area with a series of fiscal incentives to foment industrialization in the Amazon region. The Zona …

Youth Activism And The City: An Urban Political Ecology Of Flooding In Porto Alegre, Brazil, Nadine Lorini Formiga

Geography Undergraduate Senior Theses

This thesis examines the catastrophic 2024 flooding in Rio Grande do Sul, Brazil—locally known as "The Flood"—through the lens of young environmental activists' experiences in Porto Alegre. Drawing on urban political ecology, disaster studies, and climate justice frameworks, this research examines how colonial-era urban planning and infrastructure influenced the socio-environmental conditions that led to The Flood, how the disaster affected young activists' relationships with their city, and what climate justice might entail in this context. Through (auto)ethnographic fieldwork conducted from July to August 2024, including semi-structured interviews, participant observation, walk-throughs, and social media analysis, this study engages primarily with Eco …

Edc 3100 Social Science In Childhood Education Spring 2025 Syllabus, Ivana Espinet

Open Educational Resources

This course is designed to provide students with an introduction to the standards, curricula, and methods of teaching social studies in a childhood setting. The students will learn pedagogical strategies and develop critical thinking skills concerning curriculum content and the creation and implementation of classroom activities.

Message From The Editors, Anis Zaman

Hatfield Graduate Journal of Public Affairs

No abstract provided.

Trainees’ Experience Of Videoconferencing Psychotherapy Training: A Consensual Qualitative Research Study, Tin Weng Mak

Dissertations (1934 -)

As videoconferencing psychotherapy (VCP) becomes an increasingly common component of mental health service delivery, little is known about how trainees experience VCP training during their graduate education. Gaining insight into trainees’ lived experiences is essential to understanding how they navigate virtual care and how training programs can better prepare future clinicians. This study employed Consensual Qualitative Research (CQR) methodology to explore how trainees experienced their VCP training and how it shaped their clinical development. Fifteen master’s- and doctoral-level trainees were interviewed and provided rich accounts of both the helpful and challenging aspects of VCP training. Through the use of CQR, …

The Impact Of Hazard Naming In Wireless Emergency Alerts: Enhancing Protective Action Decision Making And Organizational Attitudes, Micki Olson, Hugh Walpole, Jeannette Sutton, Lauren B. Cain, Nicholas Waugh

Emergency Preparedness, Homeland Security, and Cybersecurity Faculty Scholarship

Wireless Emergency Alerts are an important way people learn about impending threats. Yet, these messages typically lack information about the hazard that will endanger people. In this study, we examine how naming the hazard and its associated cues in a Wireless Emergency Alert influences people’s perceptions that help them make protective action decisions, including understanding, belief, personalization, deciding, response efficacy, and self-efficacy. We also measure the extent to which naming the hazard and its cues affects an organization’s reputation and perceived transparency. To do so, we conduct a 2 (message type: named hazard vs. unnamed hazard) × 3 (hazard type: …

Evaluating The Elder Justice Act: Challenges In Funding, Implementation, And Coalition Dynamics, Annabelle Weberg

Hatfield Graduate Journal of Public Affairs

The Elder Justice Act (EJA) was a significant policy that passed in 2010 as part of the Patient Protection and Affordable Care Act. The goal of the EJA was to provide public health and social service programs for preventing, detecting, and treating elder abuse. Due to limited federal discretionary spending, most programs authorized under the Elder Justice Act have not been fully funded or implemented as intended.

The paper seeks to answer this research question: What has caused the limited funding and implementation of the Elder Justice Act, and what role have coalitions played? It analyzes the factors that have …

Is Education Regulation The Solution To Help Lower Substance Use Rates And Substance Use Disorder In Oregon Youth?, Sophia R. Swain

Hatfield Graduate Journal of Public Affairs

How can we lower Oregon’s youth substance use disorder (SUD) and overdose rates? Oregon is third in the country for SUD, with 5.77% of adolescents (12-17) having documented SUD. Some claim that it is because of the decriminalization of drugs, like Senator Art Robinson, but another reason relies on how we are educating Oregon youth. Oregon education standards outline requirements for drug and alcohol education as well as Senate Bill 238. By analyzing school districts current prevention programs in high overdose-rate counties (Multnomah, Lane, and Josephine) and low overdose-rate counties (Washington, Yamhill, Linn, Deschutes, Marion, and Clackamas), a lack of …

Transportation Policy And Indigenous Ways Of Knowing: What Counts As Evidence In Tribal Policy Contexts?, Cole Grisham Aicp

Hatfield Graduate Journal of Public Affairs

Evidence-based policy making is the notion that policy decisions should be based on (1) rigorous data collection and research and (2) focus on ‘what works.’ This approach aligns with the broader theory of New Public Management (NPM), which contends that the public sector should adopt the practices of and operate more like the private sector, including a reliance on measuring performance. That said, the application of evidence-based policy approaches to Tribal contexts is often difficult, if not impossible, due to the reliance on oral traditions rather than data collection. The result is that Tribal contexts are often underrepresented in contemporary …

One Health Integration To Control And Prevent Zoonoses: Application Of Organizational Theory Literature, Lisset M. Dumet Poma, Sherril Gelmon, Julia M. Goodman, Seth E. O’Neal

Hatfield Graduate Journal of Public Affairs

Zoonoses are infectious diseases transmitted between animals and people that disproportionately affect low- and middle-income countries (LMICs). The One Health (OH) approach aims to integrate systems, incentivizing collaboration among animal, human, and environmental systems to address zoonoses and improve health. Innovative solutions for effectively and sustainably achieving systems integration are needed. Organizational theories can facilitate the study of the context of OH implementation, applying comprehensive approaches that recognize the interconnections among organisms, the environment, and social systems, including the diverse entities needing integration (e.g., policy, community, public organizations). This narrative review examines organization and systems literature to provide recommendations for …

Gen Z Hybristophilia: The Role Of Tiktok In Young Women’S Attraction To Deviant Men, Emma Virginia Treggia, Maria Ioannou, Calli Tzani, David Lester, Lucas Rogers, Thomas James Vaughan Williams, John Synnott, Michelle Drouin

Health Services and Informatics Research

This research explores hybristophilia (an individual’s sexual interest in and attraction to those who commit crimes) among Generation Z women, particularly through investigating how Gen Z female users interact with and feel about hybristophilic content and how this content impacts their attraction to offenders. Study 1 involved a content analysis of 66 videos and 91 comments on TikTok, identifying seven main themes: The Halo Effect, Actor-Offender Transference, Sympathy, Romance and APD, Protection and Loyalty, “I Can Fix Him,” Gen Z Irony, and Victim Fantasy. Study 2 used a cross-sectional survey with 95 women aged 18–27 to measure exposure to and …