Digital Commons Network^™

Concurrent Presentation Of An Anomalous Right Coronary Artery And An Unusual Bovine Arch: Case Report, Vasiliki Tasouli-Drakou, Jasmine Dugal, Divuansh Sharma, Kachon Lei, Chowdhury Ahsan

Department of Internal Medicine Faculty Research

Anomalous coronary arteries from the opposite sinus of Valsalva are rare but can increase the risk for life-threatening complications. We present the case of a 59-year-old man who was found to have an anomalous right coronary artery and a rare bovine arch variant with a single common brachiocephalic trunk, along with severe proximal left anterior descending artery stenosis on left heart catheterization. The patient underwent a minimally invasive coronary artery bypass graft and unroofing of the anomalous coronary artery. To our knowledge, this is the first reported case of these concurrent anomalies in an individual without tetralogy of Fallot.

Comparing The Mechanical Properties Of Conventional, Milled, And 3d-Printed Occlusal Splint Materials: An In Vitro Study, Sadeem Alzaghran

Master's Theses (2009 -)

Aim: Evidence on the mechanical properties of digitally manufactured occlusal splint materials remains scarce. The aim of this study was to evaluate and compare the mechanical properties of CAD/CAM fabricated occlusal splint materials versus conventionally heat-cured acrylic resin materials. Materials and Methods: A total of 100 specimens were manufactured for the present study. One CAD-CAM milled (ProArt CAD Splint), one heat-polymerized (SR IVOcap Clear), and three 3D-Printed (KeySplint Hard, NightGuard Firm2 and RoDIN Splint 2.0) resin materials were evaluated. Flexural strength, flexural modulus and surface hardness were measured. The three-point flexure test was used for the determination of flexural strength …

Illness Severity And Marital Communication In Young Couples: The Moderating Role Of Marital Satisfaction, Jaime Lea Dick

Theses and Dissertations

The emergence of a chronic physical illness is unexpected in emerging adulthood and is accompanied by stress. Additionally, married partners of individuals with physical illnesses are likewise affected by the new diagnosis. Marriage outcomes of couples facing chronic illnesses together vary, being sometimes positive and sometimes negative. The current study examined the relationship between the emergence of chronic physical illness in emerging adults and marital communication of both the patient and partner, with marital satisfaction as a moderator. Gender differences are also addressed. From the Couple Relationships and Transition Experiences (CREATE) study, a nationally representative dataset of newly married emerging …

Microrna Signatures In Dental Pulp Stem Cells Following Nicotine Exposure, David Vang, Leyla T. Hardin, Nabil Abid, Der Thor, Nan Xiao

Pacific Faculty Work

Background and Objectives: Nicotine is the most well-studied toxic substance in cigarette smoke and e-cigarette vape. However, smoke and vape are composed of other components that have a negative impact on health. The objective of this study is to investigate whether nicotine has a distinctive impact on molecular mechanisms in stem cells. Methods: The cellular impact of nicotine on the regenerative capacity of human dental pulp stem cells (DPSCs) and the microRNA (miRNA) profile was examined. Bioinformatic analysis was performed to identify miRNA-regulated cellular pathways associated with nicotine exposure. These pathways were then compared to those induced by cigarette smoke …

Teaching In Authentic Ways: Exhibit Work And Student Curators In Special Collections, Rebecca Fitzsimmons

Faculty and Staff Publications – Milner Library

Engaging students in exhibit work offers them a chance to learn new skills and grow as scholars while producing a tangible and public-facing project outcome from their coursework. From learning to communicate complex ideas to making research connections between rare and primary sources, exhibit curation relies on building research skills, sharpening writing and communication techniques, and developing critical thinking skills. Pushing and refining ideas is an essential part of the iterative process of research, and exhibit curation invites students to learn this practice in a real-world, project-based way. More specifically, it requires students to read, review, compare, and analyze more …

Cloud-Assisted Multi-Channel Data Broadcasting, Debabrata Maji

Master’s Dissertations

The convergence of Internet of Things (IoT) and cloud computing has transformed technology, impacting commerce, industrial production, data management, etc. Multi- Channel Broadcast Encryption (MCBE), first introduced by Phan et al. (ASIACCS 2013), is a cryptographic encryption primitive used for both IoT and Cloud that permits a sender to e!ciently and securely encrypt several messages for di”erent groups of receivers. After thoroughly exploring the existing literature, we observe that none achieves the robust provable security within the standard model. This paper addresses this gap, aiming to achieve adaptive INDistinguishable under full-IDentity Chosen-Ciphertext Attack (IND-ID-CCA) security by constructing an e!cient identity-based …

Infectious Scleritis: A Comprehensive Narrative Review Of Epidemiology, Clinical Characteristics, And Management Strategies, Hamidreza Ghanbari, Masoud Rahimi, Ali Momeni, Kiana Hassanpour, Nikoo Bayan, Karen E. Lee, Alex Hansen, Ali R. Djalilian, Christopher J. Rapuano, Mohammad Soleimani

Wills Eye Hospital Papers

This study aims to provide an update on infectious scleritis (IS). A comprehensive search was conducted using Google Scholar, Scopus, and PubMed. IS is a rare but critical condition that presents significant diagnostic challenges and often leads to poor visual outcomes. It accounts for approximately 5%-10% of scleritis cases and warrants significant attention due to its delayed diagnosis. Ocular surgery is the primary contributor to IS, accounting for a substantial proportion of cases ranging from 58% to 83%, followed by trauma contributing to approximately 10% of cases. IS can be caused by various microorganisms, including bacteria (86%-87%), fungi (11%-13%), viruses, …

Using The Safety Scissors: Dna Resection Regulation At Dna Double-Strand Breaks And Telomeres, Michael M, Soniat, Logan R. Myler

Department of Biochemistry and Molecular Biology Faculty Papers

DNA resection is a universal process in genome maintenance by which one strand of DNA is degraded, leaving the other strand intact. This sometimes highly processive process is critical for many forms of DNA damage repair, replication-coupled repair, meiotic recombination, and telomere maintenance. Therefore, resection must be tightly regulated to prevent genome instability and promote faithful and accurate repair. Here, we review what is known about how resection functions and how it is controlled, using DNA double-strand break repair and telomere maintenance as examples. We address how resection is regulated in three independent steps: resection initiation, long-range processing, and termination. …

Another Step In The Anti-Abortion Agenda, Aziza Ahmed

Shorter Faculty Works

Trump’s recently passed “One Big, Beautiful Bill” bars Medicaid reimbursements to Planned Parenthood for one year – a provision now temporarily blocked after Planned Parenthood filed suit. But the measure builds on, and must be read against, the backdrop of Medina v. Planned Parenthood, a recent and disastrous Supreme Court ruling initiated by South Carolina and now poised to inspire copycat efforts in other states. The case starkly illustrates the Court’s continued alignment with an anti-abortion agenda advanced through state governments. As Justice Jackson forcefully argued, the decision forms part of a broader assault on civil rights – and …

Enhancing Onboarding And Role Transition For Advanced Practice Clinicians Through The Development Of A Structured Mentorship Program, Christina Sternesky

Walden Dissertations and Doctoral Studies

The assimilation of advanced practice clinicians (APCs), nurse practitioners, and physician assistants into healthcare systems is significantly dependent on the quality of their onboarding experience and the availability of a structured mentorship program. Without mentorship programs, APCs often experience job dissatisfaction, reduced confidence, undefined role clarity, and increased burnout. In this quality improvement Doctor of Nursing Practice project, I conducted a comprehensive assessment of the needs of APCs and subsequently developed a structured, evidence-based mentorship program. The program, approved by an expert panel, was designed to support the onboarding of APCS, their role transition, and ongoing professional development within a …

Association Between Homelessness And Maternal Health Outcomes Among Non-Hispanic Black Women In Georgia, Miranda Weaver

Walden Dissertations and Doctoral Studies

Maternal health disparities among homeless non-Hispanic Black women in Georgia represent a critical public health concern, driven by inequitable access to care and elevated risks of adverse pregnancy outcomes. This study examined how homelessness influences perinatal care utilization (timing and frequency of prenatal visits and postpartum checkups) and pregnancy complications (gestational diabetes, hypertension, and depression), and whether these associations differ by geographic context (urban versus rural). Grounded in the Social Determinants of Health framework, the study used a quantitative cross-sectional design, analyzing secondary data (n = 1,540; weighted ≈ 203,571) from Phase 8 (2017–2021) of the Pregnancy Risk Assessment Monitoring …

The Covid-19 Lockdown And Diabetes Self-Management In Esan Northeast Area Of Edo State, Esther Ehivbaun Rapu

Walden Dissertations and Doctoral Studies

The COVID-19 lockdown impacted chronic diseases care globally, but there is limited research on how individuals in rural Nigerian communities managed diabetes during this period. This qualitative phenomenological study explored the lived experiences of self-management with diabetes during the COVID-19 lockdown among adults in Esan Northeast. The socioecological model (SEM) served as the guiding conceptual framework, allowing for the exploration of the impact of individual, interpersonal, community, and institutional factors on self-care behaviors. The research explored how cultural, social and economic factors impacted how adults with diabetes in Esan Northeast managed their condition during the COVID-19 lockdown. Semi-structured interviews via …

Effects Of Long Covid On Healthcare Utilization, Michael Gottlieb, Erica S. Spatz, Huihui Yu, Imtiaz Ebna Mannan, Michelle Santangelo, Caitlin Malicki, Nicole L. Gentile, Rachel E. Geyer, Alex Charlton, Jonathan W. Dyal, Joann G. Elmore, Kristyn Gatling, Mandy J. Hill, Juan Carlos C. Montoy, Kelli N. O'Laughlin, Kristin L. Rising, Sharon Saydah, Kari A. Stephens, Ralph C. Wang, Lauren E. Wisk, Arjun K. Venkatesh, Robert A. Weinstein

Jefferson Center for Connected Care Faculty Papers

BACKGROUND: While most research on Long COVID (LC) has focused on symptoms and quality of life, there remains a critical need to better understand the effect of LC on resource utilization. This study sought to determine the type and amount of healthcare utilization among participants with versus without LC.

METHODS: This was a secondary analysis of a prospective, longitudinal, multicenter U.S. study of adult participants with symptomatic COVID-19, confirmed with testing, who completed 3-month post-infection surveys and had electronic health record data for at least 180 days pre- and post-index testing. We excluded participants with any COVID-19 infections within the …

One-Year Clinical Outcomes In Patients With Acute Coronary Syndrome Treated With Clopidogrel Versus Prasugrel Versus Ticagrelor: Results Of The Polish Registry Of Acute Coronary Syndromes (Pl-Acs), Julia M. Umińska, Michał Skrzypek, Małgorzata Ostrowska, Piotr Adamski, Aldona Kubica, Piotr Niezgoda, Robert Gajda, Marek Gierlotka, Bartosz Hudzik, Wiktor Kuliczkowski, Diana A. Gorog, Paul A. Gurbel, Jolanta Siller-Matula, Łukasz Szarpak, Michael Savage, Grzegorz Skonieczny, Udaya Tantry, Przemysław Trzeciak, Eliano P. Navarese, Jacek Kubica, Mariusz Gąsior

Division of Cardiology Faculty Papers

BACKGROUND: Efficient dual antiplatelet therapy is crucial in reducing adverse cardiovascular events in patients with acute coronary syndrome (ACS). Comparative effectiveness between clopidogrel, prasugrel, and ticagrelor remains unclear in real-world settings.

AIMS: The objective was to evaluate one-year clinical outcomes in ACS patients treated with clopidogrel, prasugrel, or ticagrelor using data from the Polish Registry of Acute Coronary Syndromes (PL-ACS).

MATERIAL AND METHODS: This retrospective cohort study analyzed 381 278 ACS patients from the PL-ACS registry from 2009 to 2022, who were treated with clopidogrel, prasugrel, or ticagrelor during hospitalization with a 12-month consistent regimen. The primary outcome was one-year …

Multiscale Modeling And Dynamic Mutational Profiling Of Binding Energetics And Immune Escape For Class I Antibodies With Sars-Cov-2 Spike Protein: Dissecting Mechanisms Of High Resistance To Viral Escape Against Emerging Variants, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

The rapid evolution of SARS-CoV-2 has underscored the need for a detailed understanding of antibody binding mechanisms to combat immune evasion by emerging variants. In this study, we investigated the interactions between Class I neutralizing antibodies—BD55-1205, BD-604, OMI-42, P5S-1H1, and P5S-2B10—and the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein using multiscale modeling, which combined molecular simulations with the ensemble-based mutational scanning of the binding interfaces and binding free energy computations. A central theme emerging from this work is that the unique binding strength and resilience to immune escape of the BD55-1205 antibody are determined by leveraging a broad epitope …

Insights From The Front Line: Uplifting Stories Of The Covid-19 Pandemic Through The Eyes Of The Public Health Workforce In Iowa, Heidi Haines, Amanda Sursely, Hanh Pham, Rylee Beltran, Daniel K. Sewell, Lina Tucker Reinders, Natoshia Askelson, Sarah Dixon, Kaitlin Emrich, Christine Estle, Michelle Lewis, Jimmy Reyes

Faculty Publications

Introduction: SARS-CoV-2 was declared a pandemic in March 2020. Studies have characterized some of the negative impact of the pandemic on public health workers (PHW), but few have explored the strength and coping strategies used. Our study documents the experiences of PHW in Iowa during the pandemic. Methods: We used an innovative mixed methods data collection tool, SenseMaker^® to gather stories from PHW in Iowa between March and July 2022. Participants provided additional data about their story via structured follow-up questions. We conducted descriptive analyses of the quantitative questions. A qualitative thematic and sentiment analysis was applied to all …

Comparing Dosimetric Outcomes Of Static Imrt And Vmat In Accelerated Partial Breast Irradiation For Medially Located, Left-Sided Tumor Beds, Rani Jamil

Masters Projects

Abstract

Introduction: Accelerated partial breast irradiation (APBI) has emerged as a targeted alternative to whole-breast irradiation for early-stage breast cancer, particularly for patients with medially located, left-sided tumors. Static intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) offer advanced dose conformity, yet no direct comparisons between static IMRT and VMAT have been conducted specifically for medially located, left-sided APBI, a uniquely challenging anatomical subgroup. This study evaluates dosimetric differences between static IMRT and VMAT plans to determine which modality provides superior target coverage and organ-at-risk (OAR) sparing in left-sided APBI.

Methods: Ten patients with medially located left-sided breast …

Goddard V. Saunders

All Decisions

A landlord's holdover petition was dismissed after the court granted the tenant's motion for summary judgment. The court found that the landlord vitiated the predicate termination notice by accepting rent payments from the tenant for eight months between the filing of the petition and the service of the pleadings. Citing precedent from **92 Bergenbrooklyn, LLC v Cisarano**, the judge ruled that "commencement" for the purpose of vitiation is keyed to service, not filing, and that he was constrained to follow this precedent despite the significant delay in court scheduling.

Relapse Of Acute Myelogenous Leukemia With History Of Myeloproliferative Neoplasm And Exacerbation Of Pulmonary Hypertension, Maryam Kaous, Hyeon-Ju Ryoo Ali, Chi Y Ok, Cezar Iliescu, Lara Bashoura, Bela Patel, Zeev Estrov, Saadia A Faiz

Faculty, Staff and Student Publications

Background: Pulmonary hypertension (PH) has rarely been associated with myeloproliferative neoplasms (MPNs), classified as World Health Organization group 5 PH. Progression of MPN may result in acute myelogenous leukemia (AML).

Case summary: We describe a young woman with AML arising from MPN presenting with PH. Both the AML and PH were alleviated with pulmonary vasodilators and chemotherapy. The patient eventually underwent allogeneic hematopoietic stem cell transplantation, achieving remission. Several months later, she presented with respiratory symptoms and worsening of PH, signaling the relapse of her AML, subsequently confirmed with right heart catheterization and bone marrow biopsies.

Discussion: Our case highlights …

Optimizing Tobacco-Free Workplace Programs: Applying Rapid Qualitative Analysis To Adapt Interventions For Texas Healthcare Centers Serving Rural And Medically Underserved Patients, Hannah Wani, Maggie Britton, Tzuan A Chen, Ammar D Siddiqi, Asfand B Moosa, Teresa Williams, Kathleen Casey, Lorraine R Reitzel, Isabel Martinez Leal

Faculty, Staff and Student Publications

Background: Tobacco use is disproportionately high in rural areas, contributing to elevated cancer mortality, yet it often goes untreated due to limited access to care, high poverty and uninsured rates, and co-occurring substance use disorders (SUDs). This study explored the utility of using rapid qualitative analysis (RQA) to guide the adaptation of a tobacco-free workplace program (TFWP) in Texas healthcare centers serving adults with SUDs in medically underserved areas.

Methods: From September-December 2023 and May-July 2024, we conducted 11 pre-implementation, virtual semi-structured group interviews focused on adapting the TFWP to local contexts (N = 69); 7 with providers (n …

The Histone H3 Lysine 36 Demethylase Kdm2a/Fbxl11 Controls Polycomb-Mediated Gene Repression And Germ Cell Development In Male Mice, Michael T Bocker, Grigorios Fanourgakis, Kristie Wetzel, Pavel A Komarov, Hélène Royo, Alexia Rohmer, Sunwoo Chun, Ching-Yeu Liang, Hubertus Kohler, Taiping Chen, Xiaohong Mao, Mark A Labow, Reginald A Valdez, Michael B Stadler, Dirk G De Rooij, Paola Capodieci, John Tallarico, Antoine H F M Peters, Thomas B Nicholson

Faculty, Staff and Student Publications

KDM2A/FBXL11 is a Jumonji-domain containing lysine demethylase catalyzing the removal of mono- and di-methyl modifications of histone H3 lysine 36 (H3K36me1/2). While Kdm2a is required for mouse embryogenesis, its role in adult physiology has been largely unexplored. Using conditional deletion approaches, we demonstrate that Kdm2a deficiency leads to testicular atrophy and male infertility. Although spermatogonial stem cells remain unaffected, proliferating and differentiating spermatogonia exhibit delayed cell cycle progression and apoptosis. RNA-sequencing of purified spermatogonia and spermatocytes reveals Kdm2a-dependent repression of over 750 genes during spermatogonial differentiation. Chromatin immunoprecipitation followed by sequencing (ChIP-seq) demonstrates increased H3K36me2 levels at CpG-rich gene promoters …

The Microtubule-Severing Enzyme Spastin Regulates Spindle Dynamics To Promote Chromosome Segregation In Trypanosoma Brucei, Thiago Souza Onofre, Qing Zhou, Ziyin Li

Faculty, Staff and Student Publications

Microtubule-severing enzymes play essential roles in diverse cellular processes, including mitosis and cytokinesis, by modulating microtubule dynamics. In the early branching Trypanosoma brucei, microtubule-severing enzymes are involved in cytokinesis and flagellum length control, but none of them have been found to regulate mitosis. Here we report the characterization of the microtubule-severing enzyme spastin in the procyclic form of T. brucei. We demonstrate that spastin severs microtubule in vitro and overexpression of spastin disrupts spindle microtubules in vivo in trypanosomes, leading to defective chromosome segregation. Knockdown of spastin impairs spindle integrity and disrupts chromosome alignment and segregation. We further show that …

Influence Of Zinc Oxide Nanoparticles On The Efficiency Of Oxytetracycline Removal From Wastewater Using Continuous Catalytic Ozonation, Sarmad Al-Anssari, Hassanain A. Hassan, Maha K. Mohsin, Ahmed A. Mohammed

Research outputs 2022 to 2026

Antibiotics must be fully eliminated before they are released into the environment. In most cases, conventional wastewater treatment systems are not built to handle polar microcontaminants such as antibiotics. Oxytetracycline (OTC) is one of these antibiotics, an environmental hazard contaminant in aqueous solutions. Therefore, an advanced treatment method is needed for wastewater contaminated with antibiotics. In this study, we employed zinc oxide nanoparticles (ZnO), and the catalytic ozonation procedure was employed to increase the ozonation efficiency. A continuous experiment was carried out to compare the effectiveness of catalytic and single ozonation in degrading OTC in a continuous reactor. The flow …

Physical Activity Mediates Age Differences In Cognition Among Tsimane Forager-Horticulturalists, Phoebe E. Imms, Nikhil N. Chaudhari, Daniel Cummings, Daniel Eid Rodriguez, Giuseppe Barisano, Paul L. Hooper, M. Katherine Sayre, Edmond Seabright, Randall C. Thompson, M. Linda Sutherland, James D. Sutherland, Benjamin C. Trumble, Michael Gurven, Jonathan Stieglitz, Caleb E. Finch, Hillard S. Kaplan, Wendy J. Mack, Margaret Gatz, Andrei Irimia

ESI Publications

Background: The Tsimane and Moseten of the Bolivian Amazon are highly physically active and exhibit low rates of cognitive impairment and brain atrophy.

Methods: We use structural equation modelling to examine how their physical activity levels mediate the relationship between (1) age and cognition, and (2) age and cognition via brain volume (BV).

Results: Tsimane males (n = 305, mean ± SD age = 59.94 ± 9.68) and Tsimane females (n = 265, mean ± SD age = 59.28 ± 9.79) exhibit significantly higher levels of physical activity than Moseten males (n = 106, mean ± SD …

Full Issue, Iajbs Ateneo De Manila University

Journal of Management for Global Sustainability

No abstract provided.

Sbv_Dps: A Stacking-Bagging-Voting Nested Ensemble Based Diabetes Prediction System Using K-Fold Cross Validation, Sourabh Shastri, Sachin Kumar, Paramjit Kour, Vibhakar Mansotra

Mansoura Engineering Journal

With the advancement of machine learning techniques, the introduction of the most accurate model has become a necessity. In real-world scenarios, every model has some constraints and assimilates errors, so their performance is not always highly efficient; this sparked the development of ensemble learning. The ensemble approach aims to consolidate the strengths of existing approaches and minimize their weaknesses or decision-making risks. The proposed diabetes prediction system encases a resampling filter, applied to balance the dataset and model builder method, i.e., without the SBV ensemble and with the SBV ensemble method. The model is initially built without using the SBV …

Understanding The Health And Social Determinants Of Health Needs Of Resettled Afghan Refugees In Houston, Texas, Karissa Chesky, Angelica Garcia, Aaron Pathak, Imran Humza Hanif, Srijana Shrestha, Sophia Banu

Faculty, Staff and Students Publications

Purpose

Methods

Improving Door-In-Door-Out Times For Stemi Transfer Patients: Impact Of A Protocolized Autolaunch Process, Hashim Zaidi, Waleed Kayani, Eric Power, Hei Kit Chan, Sini Eapen, Benjamin Karfunkle

Faculty, Staff and Students Publications

Background: The timely transfer of patients with ST-segment elevation myocardial infarction (STEMI) to percutaneous coronary intervention-capable centers is critical for improving outcomes. Although the American Heart Association recommends a door-in-door-out (DIDO) time of ≤30 minutes, national compliance remains low.

Project rationale: At Harris Health, no patients with STEMI met this benchmark before 2022. We implemented a quality improvement (QI) initiative, including an "Autolaunch" process, to expedite STEMI transfers.

Project summary: During 2022-2023, we introduced QI initiatives, including the Autolaunch protocol, for patients with unequivocal STEMI. This process included rapid emergency medical services activation, direct catheterization laboratory transfer, and prearrival cardiologist …

Delphinium Cut Flower Production In Utah, Nick Volesky, Melanie Stock

All Current Publications

Delphinium is a perennial crop that produces tall racemes in two flushes per season. Its long stems serve as vertical line elements, adding height and balance to floral arrangements. Popular series are available in striking shades of blue, which are not commonly found among cut flowers, making delphinium an excellent choice for local market production. This fact sheet provides an overview of how to grow, harvest, and store delphinium, including yields for various cultivars. It also covers its common pests and diseases, and reviews its economic value for cut flower producers.

Constitutive Il-7 Signaling Promotes Car-Nk Cell Survival In The Solid Tumor Microenvironment But Impairs Tumor Control, Matthew Dysthe, Ishwar Navin, Dayenne Van Leeuwen, Josue Pineda, Corrine Baumgartner, Cliona M Rooney, Robin Parihar

Faculty, Staff and Students Publications

Background: Adoptive transfer of chimeric antigen receptor (CAR)-expressing natural killer (NK) cells has demonstrated success against hematological malignancies. Efficacy against solid tumors has been limited by poor NK cell survival and function in the suppressive tumor microenvironment (TME). To enhance efficacy against solid tumors, stimulatory cytokines have been incorporated into CAR-NK cell therapeutic approaches. However, current cytokine strategies have limitations, including systemic toxicities, exogenous dependencies, and unwanted TME bystander effects. Here, we aimed to overcome these limitations by modifying CAR-NK cells to express a constitutively active interleukin (IL)-7 receptor, termed C7R, capable of providing intrinsic CAR-NK cell activation that does …