Digital Commons Network^™

Ketogenic Metabolic Therapy For Treatment Refractory Mental Illness, Mackenzie R. Ketterhagen

Summer Interdisciplinary Research Symposium

This project explores the potential of Ketogenic Metabolic Therapy (KMT) as adjunctive therapy for refractory mental illness. Evidence suggests that ketogenesis can reverse mitochondrial dysfunction, a pathophysiological feature commonly associated with major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia disorder (SD), leading to measurable improvements in psychiatric symptoms, metabolic biomarkers, and body composition. While preliminary results are promising, current data are based on small sample sizes and short study durations, limiting the generalizability of findings. Therefore, KMT cannot yet be considered a broadly validated adjunctive treatment for severe mental illness. Continued research, particularly longitudinal studies, is essential to determine …

The Effectiveness Of Hypoglossal Nerve Stimulation Compared To Cpap In Obstructive Sleep Apnea, Jared L. Roland

Summer Interdisciplinary Research Symposium

Objective:
This study evaluates whether hypoglossal nerve stimulation (HNS) yields superior improvements in reducing apnea episodes, alleviating daytime sleepiness, and enhancing quality of life compared with continuous positive airway pressure (CPAP) among adult patients with obstructive sleep apnea (OSA) who are intolerant of CPAP therapy.

Methods:
A systematic literature search was conducted in PubMed, MEDLINE and Google Scholar using combinations of “hypoglossal nerve stimulation,” “obstructive sleep apnea,” and “CPAP.” PubMed yielded 337 records; MEDLINE, 105; Google Scholar, 1,080. After duplicate removal, titles and abstracts were screened against inclusion criteria: adults (≥18 years) with body mass index (BMI) < 32 kg/m², documented CPAP intolerance or failure, apnea–hypopnea index (AHI) 15–65 events/hour, English-language full texts published since 2019. Exclusion criteria were prior upper‐airway surgery, BMI > 35 kg/m², AHI …

Retinal Imaging As An Innovative Modality For Ckd Screening, Evan Minger

Summer Interdisciplinary Research Symposium

Abstract

Objective: This study evaluates the potential use of retinal imaging as a screening tool for chronic kidney disease (CKD). Since CKD is often caused by systemic conditions such as diabetes and hypertension, the microvascular damage found in the kidneys may also appear in the retina. This research explores whether retinal microvascular changes correlate with CKD indicators, potentially offering a non-invasive alternative or adjunct to traditional laboratory screening.

Methods: A structured literature search was conducted using PubMed, MEDLINE with full text, and Google Scholar. Search terms included combinations of "Retinal Imaging," "Retinopathy," "CKD," and "Risk." PubMed yielded 39 results for …

Mortality Outcomes In Traumatic Brain Injury: Mannitol Vs. Hypertonic Saline, Abigail G. Gemeinhart

Summer Interdisciplinary Research Symposium

Abstract

Objective: To evaluate whether mannitol or hypertonic saline (HS) is associated with a lower mortality rate in the management of increased intracranial pressure (ICP) in patients with traumatic brain injuries (TBI).

Methods: A systematic literature search was conducted using Google Scholar and the Valparaiso University Library database to identify studies comparing mannitol and hypertonic saline in the treatment of elevated ICP due to TBI. Search terms included variations of “mannitol,” “hypertonic saline,” “intracranial pressure,” “traumatic brain injury,” and “mortality.” A total of 3,280 results were retrieved from an initial Google Scholar search, 2,350 from a more specific …

Reviving Heritage, Soreya Ganda

Bachelor of Architecture Theses - 5th Year

Niger’s cultural identity is shaped by a rich mosaic of ethnic groups, including the Hausa, Zarma-Songhai, Tuareg, and Fulani, each with distinct traditions, building practices, and relationships to the land. For centuries, these communities lived according to their own social and spatial systems, rooted in environment-specific knowledge and craftsmanship. This balance was disrupted during the French colonial period, which began in the late 19th century and lasted until Niger’s independence in 1960. Colonial administration redrew territorial boundaries, centralized authority, and introduced foreign materials, aesthetics, and construction standards, redefining how people built and interacted with their environments. While Niger now appears …

The Parthenon, July 23, 2025, Baylee Parsons, Kaitlyn Fleming, Ashton Pack, Nate Harrah, Soleil Woolard

The Parthenon

No abstract provided.

Ibrutinib In Combination With Lenalidomide Revlimid/Dexamethasone In Relapsed/Refractory Multiple Myeloma (Aft-15)., Yvonne Efebera, Vera Suman, Shira Dinner, Taylor O'Donnell, Ashley Rosko, John Mckay, Peter Barth, Patrick Hagen, Saad Usmani, Paul Richardson, Jacob Laubach

Oncology Articles

BACKGROUND: Studies have suggested a synergism between lenalidomide (LEN) and ibrutinib (IBR) in multiple myeloma (MM). Both downregulate IRF4, a key target and master transcriptional factor regulating myeloma cell survival.

METHOD: A 3 + 3 phase I trial was conducted to determine the maximum tolerated dose (MTD) of IBR in combination with LEN + dexamethasone (DEX) in patients with relapsed/refractory (RR) MM who had at least one prior line of therapy. Three dose levels (DLs) were planned. The cycle length was 28 days. IBR was administered orally daily in doses of 560 mg on DL1-2 and 840 mg on DL3, …

The Evolving Future Of Work: Implications For Newcomer Adaptability And Connectivity During Organizational Socialization, Talya N. Bauer, Berrin Erdogan, Allison M. Ellis, Donald M. Truxillo, Grant M. Brady, Julie M. Mccarthy

Business Faculty Publications and Presentations

Organizational socialization and the practice of onboarding new hires are central human resources functions. However, traditional socialization theory and practice were built on assumptions that are increasingly misaligned with today's work context. We identified four current, emerging, and future work trends that characterize the evolving landscape surrounding organizational socialization: technological advancement, the expansion of remote work arrangements, rising societal loneliness and mental health challenges, and aging workforce demographics. Collectively, these trends have contributed to dramatic shifts in the context and performance of work, as well as the expectations that employees and organizations hold for one another. Accordingly, we argue that …

Temporal And Generational Changes In Depression Among Young American Adults, Ashley W. Kranjac, Dinko Kranjac, Valentine Chung

Sociology Faculty Articles and Research

The prevalence of depression among young American adults has risen significantly over the past two decades, but the mechanisms that underlie the population-level changes in depressive symptoms severity remain unclear. We used data from the 2005–2023 National Health and Nutrition Examination Survey (NHANES) and hierarchical age–period–cohort (HAPC) analysis to examine developmental (i.e., age), life stage (i.e., period), and generational (i.e., cohort) distribution of depressive symptoms among American adults aged 20–30 years old over an 18-year period. Our model results indicate that the probability of either mild, moderate, or severe depression increased among young adult females and males between 2005 and …

The Influence Of Underwriter Reputation And Firm Age On Ipo Pricing Decision: A Study On Companies Conducting Ipos On The Indonesia Stock Exchange In 2021–2024, Daniel Nathan, Prima Yusi Sari

Journal of Accounting Auditing and Business

This study aims to analyze the effect of underwriter’s reputation and firm age on IPO pricing decision among companies that went public on the Indonesia Stock Exchange (IDX) during the period 2021 to 2024. A quantitative approach was employed using multiple linear regression to examine the relationships between variables. The study’s sample consists of 229 companies that conducted IPOs within the specified period. The independent variables include underwriter’s reputation, categorized based on transaction volume rankings, and firm age, calculated as the difference between the year of establishment and the IPO year. The dependent variable is IPO pricing decision, represented by …

Investigating The Impact Of Agent Openness On Planning In Multi-Agent Systems, Bala Subramanyam Duggirala

School of Computing: Dissertations, Theses, and Student Research

Multi-agent systems (MAS) possess significant potential for modeling real-world scenarios requiring coordinated actions (like wildfire fighting or ridesharing) among autonomous entities or agents (e.g., wildfire fighting agents) in complex, dynamic environments. Effective decision-theoretic planning (where each agent must carefully consider both the immediate and the future situations or states, and coordinate with the other agents (neighbors) to evaluate what needs to be done at present) within MAS, especially multiagent planning, where the planning agent directly models its neighbors in order to estimate their optimal actions, is critical, yet challenged by factors like partial observability, openness, and diverse agent types with …

Longitudinal Associations Between Waking Movement Behaviors And Health-Related Quality Of Life In Older Adults: A Compositional Data Analysis Approach, Jaclyn P. Maher, Alexander Jochim, Yeongjun Seo, Brynn L. Hudgins, Iman F. Khan, Peyton A. Greco, Emily M. Postlehwait, Om L. Patel, Krista S. Leonard, Chih-Hsiang Yang, Denver M. Y. Brown

Faculty Publications

Objectives

Movement behaviors, such as sedentary behavior (SB), light intensity physical activity (LPA), and moderate to vigorous intensity physical activity (MVPA) are mutually exclusive, in that time spent in one behavior inevitably displaces time spent in another. Yet, few studies have simultaneously considered these health behaviors and their association with health-related quality of life (HRQoL), an important indicator of health and well-being in aging populations. This study aimed to explore the role of waking movement behaviors (i.e., SB, LPA, MVPA) in prospectively predicting HRQoL in older adults. The study further aimed to cross-validate associations between movement behaviors and HRQoL using …

An Ai-Driven Framework For Real-Time Fake News Detection: Developing A Machine Learning-Based Filter For News Platforms In The United States, Umma Twaha, Yeasin Arfin

Engineering and Technology

The proliferation of fake news across digital platforms poses a significant threat to democratic processes, public health, and social cohesion in the United States. Manual fact-checking and traditional moderation approaches are increasingly inadequate due to the scale, speed, and sophistication of misinformation campaigns. This presents an AI-driven framework for real-time fake news detection, designed to serve as an intelligent filter for news platforms operating within the US media ecosystem. Leveraging natural language processing (NLP) techniques and machine learning algorithms—including supervised classifiers and deep learning models such as BERT and LSTM—the framework identifies deceptive content with high precision and low latency. …

Gene Therapy Ameliorates Neuromuscular Pathology In Cln3 Disease, Ewa A Ziółkowska, Albina Jablonka-Shariff, Letitia L Williams, Matthew J Jansen, Sophie H Wang, Elizabeth M Eultgen, Matthew D Wood, Daniel A Hunter, Jaiprakash Sharma, Marco Sardiello, Robyn Reese, Alan Pestronk, Mark S Sands, Alison K Snyder-Warwick, Jonathan D Cooper

2020-Current year OA Pubs

CLN3 disease is a neuronopathic lysosomal storage disorder that severely impacts the central nervous system (CNS) while also inducing notable peripheral neuromuscular symptoms. Although considerable attention has been directed towards the neurodegenerative consequences within the CNS, the involvement of peripheral tissues, including skeletal muscles and their innervation, has been largely neglected. We hypothesized that, CLN3 deficiency could directly influence peripheral nerves and investigated the neuromuscular system in Cln3

Zero Trust Architecture For Electric Transportation Systems: A Systematic Survey And Deep Learning Framework For Replay Attack Detection, Grace Muriithi, Behnaz Papari, Ali Arsalan, Laxman Timilsina, Alex Muriithi, Elutunji Buraimoh, Asif Khan, Gokhan Ozkan, Christopher Edrington, Akram Papari

Montclair State University Scholarship & Creative Works

Modern and autonomous hybrid electric vehicles (HEVs), as complex cyber-physical systems, represent a key innovation in the future of transportation. However, the increasing interconnectivity and reliance on digital components expose these vehicles to significant cybersecurity risks. To address these challenges, Zero Trust Architecture (ZTA) has emerged as a promising security framework. Operating on the principle of ‘never trust, always verify,’ ZTA offers a comprehensive approach to ensuring continuous trust verification in HEV systems. Despite its potential, the application of ZTA within cyber-physical vehicular systems remains underexplored, and its practical benefits and limitations are not yet fully understood by the engineering …

New Paradigms In E. Coli Hemolysin Function And Pathogenesis, Hunter Winston Kuhn

Arts & Sciences Graduate Student Theses and Dissertations

Bacterial pore-forming toxins are potent secreted protein effectors that disrupt cellular ion homeostasis by integrating into the plasma membrane. Among them, the RTX toxin alphahemolysin (HlyA) from uropathogenic Escherichia coli (UPEC) has been extensively studied for its hemolytic activity, broad cell tropism, and role in virulence. HlyA was identified as the first type 1 secreted substrate, with β2 integrin CD18/LFA-1 proposed as its receptor. However, its diverse mechanisms of cellular toxicity and impact on outcomes of urinary tract infection (UTI) have remained incompletely defined. During pyelonephritis, renal epithelial cells are at the front line of infection, directly contacting ascending UPEC …

Prediction Of Underground Cable Health Index Based On Iga‑Bp Neural Network, Jinbo Huang, Guoping Zou, Jiange Jiao, Xiangrong Chen, Tianjian Zhao

Journal of Electric Power Science and Technology

With cable equipment being widely deployed, cable faults have threatened the safe operation of the power grid. Traditional operation and maintenance work has difficulty in accurately predicting the current health status of cable insulation. To address this issue, a cable health index prediction method based on an improved genetic algorithm-back propagation (IGA-BP) neural network model is proposed. Since the rate of parameter change in underground cables varies at different aging stages, the method incorporates recent aging trend characteristics into both the fitness function and mutation operator during parameter optimization. By distinguishing individuals based on these aging characteristics, the model enhances …

The Influence Of Myocardin Effector Genes On The Tgf-Beta Smad3 Signaling Pathway In Human Pleural Mesothelial Cells, Hema Chandra Hrushi Dusharla

Biotechnology Theses

Pleural Fibrosis (PF) involves excessive extracellular matrix (ECM) deposition, mainly by myofibroblasts, leading to pleural thickening and impaired lung function. Pleural mesothelial cells (PMCs) contribute via mesothelial and mesenchymal transition (MesoMT), triggered by cytokines like TGF-β. Our lab identified Myocardin (MyoCD), a transcriptional co-activator of cardiac and smooth muscle, is a master regulator of pleural fibrosis through interactions with serum response factor (SRF) and Smad2/3 transcription factors which initiate fibrosis signaling. RNA sequencing and qPCR analysis revealed that silencing MyoCD decreased the expression of CTNNB1, MDFI, and Tspan2. MDFI emerged as a potent candidate, as this gene affecting the expression …

Staff Education To Outpatient Healthcare Staff On Managing Patients With Aggressive Behaviors, Adeline Fonkem Asonganyi

Walden Dissertations and Doctoral Studies

The aim of this staff educational project was to improve staff knowledge by educating healthcare staff on how to minimize patients’ aggressiveness and provide a safer, more therapeutic environment for patients and healthcare providers. Patients with mental health problems can exhibit violent behavior, posing threats to patient safety and the safety of healthcare workers. To address this practice gap, I conducted a literature review; 509 articles were identified and then narrowed to 23 articles specific to this topic. The project question for my study was: Does implementing an educational program for nurses and mental health specialists on strategies to reduce …

The Influence Of Sociodemographic Factors On Opioid Mortalities In The U.S. State Of Georgia, Theresa Highsmith

Walden Dissertations and Doctoral Studies

Since the late 1990s, the United States has been in the midst of an opioid epidemic that continues to present significant public health challenges. Opioid-related mortality, particularly involving fentanyl, has disproportionately affected vulnerable populations. The purpose of this quantitative study was to examine the associations between educational level, homelessness, and alcohol use with opioid-related overdose deaths involving fentanyl, while controlling for age, gender, and marital status, among Black and White populations in the U.S. state of Georgia. The theoretical framework was Bronfenbrenner’s socioecological model, which recognizes that individual behavior is influenced by multiple levels of factors, including interpersonal, community, and …

Discord From Within: Challenges Facing Catholicism In The United States And The Road Ahead, Amber Montgomery

Say Something Theological: The Student Journal of Theological Studies

As membership in the Catholic Church continues to decline in the United States, there are less parishioners or those interested in religious life. Two contributing reasons for this include the Church’s stance on the use of contraception and the role of women within ministry. Explored here is a brief survey of these issues based on Scripture, papal documents, feminist theology, and the perspective of clergy and lay persons. These two topics are of particular interest as the United States grapples with women’s rights over their bodies and wrestle with women’s place within the Church. While the Church has taken an …

Re: Comment Letter For The Draft Final Butte Priority Soils Operable Unit (Bpsou) 2022 Unreclaimed Sites Sampling: Ur-20 Site Evaluation Summary Report (Dated March 19, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Effects Of Oxygen Manipulation On Myofibroblast Phenotypic Transformation In Patients With Radiation-Induced Fibrosis, Eric Mastrolonardo, Sarah Sussman, Bo Yun, Victor Jegede, Dev Amin, Joel Rosenbloom, Andrew P. South, Voichita Bar-Ad, Peter J Wermuth, Adam J. Luginbuhl

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

We tested if hyperoxic conditions can reduce the proportion of active myofibroblasts, which are assumed to be a major driver of head and neck radiation-induced fibrosis, as measured by expression levels of pro-fibrotic genes. Radiated, non-cancerous soft tissue from the head and neck and skin/soft tissue from non-radiated flap donor site were collected from each patient. Myofibroblast density was quantified using immunofluorescence staining with α-SMA and DAPI and visualisation under confocal microscopy and compared between baseline non-radiated and radiated tissue from the same patient. From each tissue specimen, fibroblast cell lines were cultured and exposed to either normoxic, hypoxic, or …

Analog Chip May Be Key To Unlocking Ai Power, Jordan Karnbach

University of Mississippi News

OXFORD, Miss. – Most computers use digital systems that separate memory, where data is stored, and processing, where it is used. This setup wastes energy because the computer must constantly move data back and forth, but a University of Mississippi professor is working to develop a more efficient alternative.

Macrophage-T Cell Interactions Promote Slamf1 Expression For Enhanced Tb Defense, G V R Krishna Prasad, Steven J Grigsby, Gideon A Erkenswick, Cynthia Portal-Celhay, Ekansh Mittal, Guozhe Yang, Samuel M Fallon, Fengyixin Chen, Thais Klevorn, Neharika Jain, Yuanyuan Li, Makedonka Mitreva, Amanda J Martinot, Joel D Ernst, Jennifer A Philips

2020-Current year OA Pubs

CD4+ T cells are crucial for protective immunity to intracellular pathogens. In addition to secreting cytokines, CD4+ T cells promote control of Mycobacterium tuberculosis infection through cognate interactions with macrophages, but the mechanism has been unclear. Here, we show that SLAMF1/CD150 is highly and uniquely induced in macrophages by antigen-specific interactions with CD4+ T cells. In macrophages, SLAMF1 enhances the generation of reactive oxygen species and restricts Mtb replication. Mtb-infection of mice promotes SLAMF1 expression specifically on infected macrophages, not uninfected bystanders. SLAMF1 expression depends on adaptive immunity and also autophagy. Moreover, Slamf1

Sepsis Restructures The Mitochondrial Calcium Uniporter Complex In The Lymphoid Tissues Of Mice And Humans, Xianghong Zhang, Jianguo Lin, Baobo Zou, Jack R Killinger, Andrew C Sayce, Thiagarajan Meyyappan, Zeyu Xiong, Melanie J Scott, Janet S Lee, Matthew R Rosengart

2020-Current year OA Pubs

Survivors of sepsis suffer from an elevated risk of premature death that is not explained by a higher burden of chronic diseases prior to the infection. Nearly 1 out of 4 survivors have persistent elevations of inflammation biomarkers, such as interleukin (IL) 6. These observations suggest that sepsis imparts durable changes to organismal biology. Eukaryotic life depends upon ATP and calcium (Ca

Environmental, Social, And Molecular Regulation Of Foraging Behavior In The Formosan Subterranean Termite, Arjun Khadka

LSU Doctoral Dissertations

Foraging is a critical activity in social insects, essential for resource acquisition and colony sustenance. In termites, this behavior is shaped by environmental, social, and genetic factors, yet the underlying regulatory mechanisms remain poorly understood. In this study, we examined how environmental food and moisture availability, and the age of termites affected foraging activities, along with the molecular regulation of foraging in the Formosan subterranean termite, Coptotermes formosanus, using a combination of behavioral assays, transcriptomics, and molecular biology approaches. First, we demonstrate that food and moisture deprivation (FMD) significantly affects foraging, with termites under deprivation conditions exhibiting increased foraging …

Public Support For Puma Reintroduction In The Eastern United States, L. Mark Elbroch, Jazmin J. Murphy, Shelby C. Carlson, John A. Vucetich, Richard E.W. Berl, Lexi Galiardi, Shelby Perry, Tom Butler, Neil Carter, Joseph W. Hinton, Axel Moehrenschlager, Emily Carrollo, Rana Bayrakcismith, Jeremy T. Bruskotter

Michigan Tech Publications

Pumas (Puma concolor) are among the species identified as having the potential to enhance ecosystem function. Previous research highlights sufficient ecological habitat to support pumas in the eastern United States; however, their reintroduction requires social and institutional support as well. To this end, we conducted research to assess attitudes about puma reintroduction among key constituencies like hunters, rural residents, and young people. We sampled 2756 respondents across seven states (Massachusetts, Maine, New Hampshire, New York, Pennsylvania, Vermont, and West Virginia). Ratios of strong support (for puma reintroduction) to strong opposition across states ranged from 4:1 to 13:1, and support outweighed …

Uncharted Territory: The First Case Of Cardiac Myxoma In A Patient With Nf2, Muhammad Sabri, Zinya Talukder, Naila Ijaz, Joseph Neri

Rothman Institute Papers

BACKGROUND: Cardiac myxoma is a benign tumor, typically originating in the left atrium, and is often linked to Carney complex. In our literature review, there are no case reports of cardiac myxoma in patients with neurofibromatosis type 2 (NF2).

CASE SUMMARY: A 60-year-old man presented with dizziness and was found to have meningioma and vestibular schwannoma, consistent with NF2. Cardiac myxoma was incidentally diagnosed through echocardiography and confirmed by cardiac magnetic resonance imaging and tissue pathology. The mass was surgically resected. The patient was offered genetic testing; however, he decided to not undergo further testing.

DISCUSSION: NF2 is an inherited …

Causes Of Mortality In Patients With Inborn Errors Of Immunity: An 18-Year Retrospective Cohort Study, Salem Al-Tamemi, Musab Al Jabri, Eiman Abdalla, Ibrahim Al-Busaidi, Khalfan Al-Zeedy, Laila Al Yazidi

Sultan Qaboos University Medical Journal

Objectives: Inborn errors of immunity (IEI) are a diverse group of disorders arising from defects in the development and/or function of the immune system. However, data concerning the microbiological aspects of infections and direct causes of mortality in patients with IEI are limited and fragmented. This study aimed to elucidate the causes of disease and terminal events leading to death in a cohort of patients with IEI. Methods: This retrospective study included deceased patients who were diagnosed with primary immunodeficiency at Sultan Qaboos University Hospital in Muscat, Oman, over an 18-year period between 2005 and 2023. Data on clinical features, …