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Articles 73771 - 73800 of 1791781
Full-Text Articles in Entire DC Network
Keynote Address: Community Over Constitution, Riddhi Mukhopadhyay
Keynote Address: Community Over Constitution, Riddhi Mukhopadhyay
Seattle University Law Review
In this keynote address, Riddhi Mukhopadhyay challenges the veneration of the U.S. Constitution by highlighting its origins in exclusion and its continued failure to protect marginalized communities. Drawing from her experience in civil legal aid and gender justice, she argues that the Constitution was drafted to consolidate power among white, wealthy men and continues to reflect that legacy through racial, gender, and class-based inequities. While acknowledging the significance of constitutional amendments and landmark cases, Mukhopadhyay emphasizes that meaningful change has always come from community-led action, not top-down reform. Additionally, Mukhopadhyay calls on lawyers and legal advocates to center community, practice …
The Lost Child: A Critique On Transracial Adoption Rhetoric, Hallie Conyers-Tucker
The Lost Child: A Critique On Transracial Adoption Rhetoric, Hallie Conyers-Tucker
Seattle University Law Review
Transracial adoption in the United States reflects a deeply rooted history of colonialism, cultural assimilation, and racial hierarchy, masked by rhetoric focused on the “best interest of the child.” The author critiques that rhetoric and traces how adoption practices and policies, both domestic and international, have evolved to reinforce systemic inequities. Through historical analysis of the forced adoption of Native American, Black, and Asian children, it reveals how the best interest standard has been wielded not to protect children but to uphold political and racial ideologies. The author argues that the prevailing adoption framework relies on child-saving and color-blind narratives …
A Global Reconstruction: Black Internationalism And The Human Rights Regime, Britta Redwood
A Global Reconstruction: Black Internationalism And The Human Rights Regime, Britta Redwood
Seattle University Law Review
Black American advocates for civil, political, and economic rights have long taken an internationalist approach and fostered connections with international organizations and transnational movements. This engagement has also been a generative force and played role in shaping international law. Beginning in the early years of the twentieth century, Black intellectuals and leaders, spearheaded by the NAACP and the UNIA, focused on human rights as a means for addressing and repairing the harms wrought by slavery, Jim Crow, and racism. From the Paris Peace Conference of 1919 through the Universal Declaration of Human Rights, the Genocide Convention, and the drafting of …
The Gap: Addressing The Missing Piece In HawaiʻI’S Anti-Discrimination Laws On Credit And Lending, Wendy Mun
The Gap: Addressing The Missing Piece In HawaiʻI’S Anti-Discrimination Laws On Credit And Lending, Wendy Mun
Seattle University Law Review
This author addresses the significant gap in Hawaiʻi’s anti-discrimination laws, specifically the lack of explicit protections for LGBTQ+ individuals against credit and lending discrimination. Although federal laws like the Equal Credit Opportunity Act (ECOA) and recent interpretations by the Consumer Financial Protection Bureau (CFPB) extend some protections, they remain vulnerable to shifting federal priorities and interpretations. The author explores how other states, particularly California and Washington, have enacted robust statutory protections that clearly prohibit credit discrimination based on sexual orientation and gender identity. They argue that Hawaiʻi, despite its large LGBTQ+ population, must amend its credit protection laws to reflect …
The U.S. Drug Policy Hamster Wheel: A Critical Discourse Analysis Of Seattle’S New Drug Ordinance, Hallie Conyers-Tucker
The U.S. Drug Policy Hamster Wheel: A Critical Discourse Analysis Of Seattle’S New Drug Ordinance, Hallie Conyers-Tucker
Seattle University Law Review
The author critically examines Seattle’s new drug ordinance using Critical Discourse Analysis (CDA) to reveal how legislative language influences the policy's actual effect. Although the ordinance claims to prioritize diversion and community health, the use of permissive language such as “may” and “shall” grants broad discretionary power to law enforcement and undermines the stated intent. The author situates the ordinance within a broader historical context, highlighting how drug policy in the United States has consistently been shaped by racialized and stigmatizing narratives. Additionally, the author argues that meaningful reform requires reframing the discourse around substance use to support public health …
Something Concrete: How Labor Advocates Can Best Respond To The Ambiguity Of Glacier Northwest, Ateş Serifsoy
Something Concrete: How Labor Advocates Can Best Respond To The Ambiguity Of Glacier Northwest, Ateş Serifsoy
Seattle University Law Review
The Supreme Court’s much-anticipated decision in Glacier North-west, Inc. v. International Brotherhood of Teamsters Local No. 174 (Glacier) marked a critical moment for workers’ rights under the National Labor Relations Act (NLRA) and the longstanding practice of Garmon preemption. Yet, initial fears of a significant rollback of workers’ rights, driven by sensational headlines, were met with an unexpectedly narrow Court opinion. This Comment examines Glacier’s implications for Gar-mon preemption and the right to strike. It offers the historical background of the doctrine of labor law preemption before Glacier; presents a detailed analysis of Glacier itself, including its …
Ai-Based Walkability Ecosystem: A Personalized, Social And Adaptive Solution To Urban Mobility And Public Health, Diya Singh, Gaurav Nanda, Xinran Lehto, Elizabeth A. Richards, Mark R. Lehto, Jaeil Lee
Ai-Based Walkability Ecosystem: A Personalized, Social And Adaptive Solution To Urban Mobility And Public Health, Diya Singh, Gaurav Nanda, Xinran Lehto, Elizabeth A. Richards, Mark R. Lehto, Jaeil Lee
Discovery Undergraduate Interdisciplinary Research Internship
Urban environments pose significant barriers to physical activity and public health, often due to a lack of motivation, insufficient adaptability to environmental factors, the uniformity of features in existing fitness apps, and limited opportunities for meaningful interpersonal interaction. This project proposes an AI-powered Walkability Assistant — a mobile application designed to foster healthier, more active lifestyles by addressing these challenges through personalized, adaptive, and community-oriented solutions. This project adopts two research methods—text mining and open-ended surveys—to identify latent user needs and areas for improvement in walkability applications. We conducted large-scale text mining and analyzed over two million user reviews from …
Season 2 Episode 4: The Upsides, Sara Gras
Season 2 Episode 4: The Upsides, Sara Gras
Season 02
With all the negative coverage of sports betting – concerns about gambling harms, cheating scandals, bad behavior directed towards athletes – the casual observer to wonder why we ever wanted it in the first place or why state legislators continue to push sports betting forward. The reality is that the sports betting industry has benefits, both economic and social, that make it hard to quit.
Features excerpts of interviews with:
Matt Holt, CEO (former)
IC360
Prof. Marc Edelman, Law Professor, Attorney and Sports Business Expert
Zicklin School of Business, Baruch College
Jacob Coin, Executive Advisor
San Manuel Band of …
A New Exclusionary Rule To Protect Bodily Integrity And Discourage Pretext Stops, Josephine Ross
A New Exclusionary Rule To Protect Bodily Integrity And Discourage Pretext Stops, Josephine Ross
Seattle University Law Review
The author proposes a novel state-level exclusionary rule to reduce racial profiling and protect bodily autonomy during police encounters. The current Fourth Amendment jurisprudence fails to deter pretextual stops and frisks because the exclusionary rule often turns on officer fault and "good faith," allowing racially motivated practices to go unchecked. As federal rollbacks on diversity and data collection hinder efforts to track racial bias, the author argues for a statutory evidentiary rule that automatically excludes drug evidence found during (1) traffic stops, (2) pat-downs for weapons, and (3) consent searches, regardless of an officer’s intent or the legality of the …
Navahine V. HawaiʻI Dept. Of Transportation: The Keiki Will Lead Us, Catherine Smith
Navahine V. HawaiʻI Dept. Of Transportation: The Keiki Will Lead Us, Catherine Smith
Seattle University Law Review
The author analyzes the landmark case Navahine v. Hawaiʻi Department of Transportation, which culminated in the world’s first constitutional climate settlement. Catherine Smith, serving as an expert for the youth plaintiffs, situates the case within Hawaiʻi’s legal tradition of prioritizing children’s rights and intergenerational equity. She explores the evolution of children’s constitutional protections, contrasting Hawaiʻi’s progressive jurisprudence with the dominant adult-centric legal framework on the mainland. She critiques four recurring analytical missteps in U.S. courts that marginalize children’s interests and highlights Hawaiʻi’s public trust doctrine and cultural values, such as the Aloha Spirit, as models for addressing climate-related harms. …
Generative Ai–Powered Mental Wellness Chatbot For College Student Mental Wellness: Open Trial, Jazmin A. Reyes-Portillo, Amy So, Kelsey Mcalister, Christine Nicodemus, Ashleigh Golden, Colleen Jacobson, Jennifer Huberty
Generative Ai–Powered Mental Wellness Chatbot For College Student Mental Wellness: Open Trial, Jazmin A. Reyes-Portillo, Amy So, Kelsey Mcalister, Christine Nicodemus, Ashleigh Golden, Colleen Jacobson, Jennifer Huberty
Department of Psychology Faculty Scholarship and Creative Works
Background: Colleges have turned to digital mental health interventions to meet the increasing mental health treatment needs of their students. Among these, chatbots stand out as artificial intelligence–driven tools capable of engaging in human-like conversations that have demonstrated some effectiveness in reducing depression and anxiety symptoms.
Objective: This study aimed to assess the feasibility and acceptability of using Wayhaven, an artificial intelligence chatbot, among college students with elevated depression or anxiety symptoms. We also aimed to examine the preliminary effectiveness of Wayhaven in improving symptoms of anxiety and depression, hopelessness, agency, and self-efficacy among students.
Methods: Participants were 50 racially …
House Finches Lose Feeding Preferences During Infection: Behavioral Changes With Implications For Pathogen Spread, Francis Edward Tillman
House Finches Lose Feeding Preferences During Infection: Behavioral Changes With Implications For Pathogen Spread, Francis Edward Tillman
Electronic Theses and Dissertations Archive
Foraging is a fundamental behavior that animals use to acquire food resources. Because these resources are critical for survival and reproduction, animals are often thought to forage optimally, maximizing resource intake per unit of time. While the foraging behaviors of healthy animals often align with such predictions, we know little about how or if these predictions hold true in sick animals. This is especially relevant when considering sickness behaviors, or changes in behavior that accompany infection and frequently include lethargy and anorexia, both of which may alter foraging decisions or ability. Because food resources often cause animals to aggregate, a …
Enhancing Public Transit By Integrating On-Demand And Fixed Route Transit Services: A Focus On Implementation, Adaption, Equity, And Acceptance, Avani Aravind
Electronic Theses and Dissertations Archive
As cities seek to build inclusive, efficient, and sustainable transportation systems, the integration of on-demand mobility services with traditional fixed-route transit (FRT) offers a promising solution to enhance coverage and connectivity. However, challenges persist in evaluating the cost-effectiveness, accessibility, and user acceptance of such integrated systems. This dissertation presents a comprehensive, three-part framework that addresses these gaps by (1) developing a simulation-based, pre-implementation cost evaluation model, (2) assessing the accessibility and equity outcomes of integrated systems, and (3) exploring the effectiveness of behavioral nudges in influencing transit adoption. The first study introduces an agent-based simulation model to evaluate generalized system …
Fathers Using Light Touch On Their Infants And Its Effects On Postnatal Paternal Depression, Christopher Dirkes
Fathers Using Light Touch On Their Infants And Its Effects On Postnatal Paternal Depression, Christopher Dirkes
DNP Projects
Background:
During the postpartum period there are multiple resources available to address maternal postpartum depression. However, there are limited resources available to help fathers during this transition period. Currently, limited data is available for best practice to decrease postnatal paternal depression, and increase paternal bonding and comfortability when caring for the infant.
Method:
Fathers were recruited from a Midwestern Public Health Department. After recruitment, fathers were provided with in-home education on how to perform a light touch intervention. Pre-intervention qualitative and quantitative surveys were provided at this time. Fathers were then asked to record their emotions as well as infant …
Use Of A Shoulder-Mounted Wearable Sensor Prototype Designed To Detect Opioid-Related Overdose: A Qualitative User Experience Study, Alexis M. Roth, Ally K. D'Angelo, David Gordon, Benjamin Cocchiaro, Anush Lingamoorthy, Rose Laurano, Matthew Salzman, Jacob S. Brenner, Cameron Baston
Use Of A Shoulder-Mounted Wearable Sensor Prototype Designed To Detect Opioid-Related Overdose: A Qualitative User Experience Study, Alexis M. Roth, Ally K. D'Angelo, David Gordon, Benjamin Cocchiaro, Anush Lingamoorthy, Rose Laurano, Matthew Salzman, Jacob S. Brenner, Cameron Baston
SKMC Student Presentations and Publications
BACKGROUND: For over a decade, drug overdose has been the leading cause of injury and accidental death in the United States. Most fatal overdoses involve opioids and occur during solitary drug use events when no one is available to initiate lifesaving responses (eg, naloxone). While there is a growing interest in devices providing early overdose detection and automated responses, little research has engaged end users in a device design process.
OBJECTIVE: This study aimed to describe user experience, perceived harms and benefits, and the acceptability of a shoulder-mounted wearable sensor among people who inject drugs who wore a device prototype …
Implementation Of Intimate Partner Violence Education To Improve Practice And Attitude Amongst Healthcare Providers, Abigail Nguyen, Breanna Carpenter
Implementation Of Intimate Partner Violence Education To Improve Practice And Attitude Amongst Healthcare Providers, Abigail Nguyen, Breanna Carpenter
DNP Projects
Background
Intimate partner violence (IPV) is a serious and costly public health issue. It is vital that patients are screened at least annually for intimate partner violence. Screening increases disclosure of abuse and allows primary care clinicians to provide comfort, education, and resources to patients experiencing IPV. Evidence strongly suggests that a major barrier to regular screening for IPV is a lack of knowledge and comfort amongst healthcare providers.
Purpose
This project’s purpose was to provide educational tools for healthcare providers related to the importance of screening for IPV, guidelines for most effective screening, common IPV misconceptions, and local resources. …
Evaluating Dosimetric And Treatment Efficiency In Esophageal Cancer: A Comparative Study Of Volumetric Modulated Arc Therapy, Modified Volumetric Modulated Arc Therapy, And Hybrid Radiotherapy Techniques, Julia Frost
Masters Projects
This study evaluated and compared the dosimetric outcomes and treatment efficiency of three radiation therapy techniques, Hybrid volumetric arc therapy (H-VMAT), Modified volumetric arc therapy (M-VMAT), and traditional Three-Arc volumetric arc therapy (T-VMAT), in the treatment of lower-third esophageal cancer. Ten patients with esophageal cancer located in the lower third of the esophagus were retrospectively replanned using each technique. H-VMAT combined 3-dimensional anterior-posterior/posterior-anterior (AP/PA) fields with two partial VMAT arcs. The M-VMAT technique included two full arcs and one arc with avoidance sectors. The T-VMAT technique used three full arcs. Each plan was prescribed 5040 cGy in 28 fractions using …
Association Between Sociocultural Factors, Obesity, And Depression In The Hispanic/Latino Population, Maia Junco
Association Between Sociocultural Factors, Obesity, And Depression In The Hispanic/Latino Population, Maia Junco
Walden Dissertations and Doctoral Studies
The increasing prevalence of obesity and mental health disparities among Hispanic/Latino populations in the United States underscores the need to understand how sociocultural factors shape physical and psychological health. The purpose of this study was to examine how acculturation, diet quality, and fiber intake affect BMI and depressive symptoms over time. The study was guided by acculturation theory and the biopsychosocial model. The study used longitudinal secondary data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) with a sample of N=8,816, including adults who completed examination visits, 1 (2008–2011) and 2 (2014–2017). Path analysis was conducted to assess direct …
The Impact Of Non-Athletic, Flat-Soled Sneakers On Gait Kinematics: A Comparative Analysis With Socks, Aaron Aguilar, Kharen Bautista, Juan Claros, Raquel Dimaano, Ciara Franke, Mason Huber, Evan Kurishige, Anton Lam, Kevin Le, Alohi Sheung, Raj Kumar Chauhan, Sivakumar Rajagopal, Seong Hyun Moon, Michael Shiraishi, Rahul Soangra
The Impact Of Non-Athletic, Flat-Soled Sneakers On Gait Kinematics: A Comparative Analysis With Socks, Aaron Aguilar, Kharen Bautista, Juan Claros, Raquel Dimaano, Ciara Franke, Mason Huber, Evan Kurishige, Anton Lam, Kevin Le, Alohi Sheung, Raj Kumar Chauhan, Sivakumar Rajagopal, Seong Hyun Moon, Michael Shiraishi, Rahul Soangra
Physical Therapy Faculty Articles and Research
This study investigates the kinematic effects of non-athletic, flat-soled sneakers on lower extremity joints during walking. Ten healthy gym-goers (24.4 ± 1.7 years) underwent treadmill gait analysis under two conditions: wearing non-athletic sneakers and walking with only socks. Gait was captured using the Gait Real-time Analysis and Interactive Lab (GRAIL). Dependent variables included cadence, support times, and stride length. Walking with socks significantly increased cadence (p < .0001) and single support time (p = .0103), and decreased initial (p = .018), terminal (p = .0056), and total double support times (p = .0092). No significant difference in stride length was observed. These …
Explore Toolkit, Kimberly Page, Janet Page Reeves, Ivan De La Rosa, Marie Alice Scott, Christina Phillips, Maria Sanchez, Andrew Gorvetzian, Joe Albright, Cynthia Killough, Randall Benalli
Explore Toolkit, Kimberly Page, Janet Page Reeves, Ivan De La Rosa, Marie Alice Scott, Christina Phillips, Maria Sanchez, Andrew Gorvetzian, Joe Albright, Cynthia Killough, Randall Benalli
Epidemiology, Biostatistics, and Preventive Medicine
Welcome to the Exploring Health Beliefs for Community Engagement and Diversity in Clinical Trials (EXPLORE) Toolkit, a resource designed to support researchers and frontline workers addressing substance use in the Borderlands. The EXPLORE Toolkit was designed by an interdisciplinary team of epidemiologists, social workers, anthropologists, and public health professionals to enhance the engagement of underrepresented communities in substance use clinical trials. Utilizing a strength-based approach, the toolkit addresses equity, stigma, and participation barriers, promoting culturally sensitive and community-centered research practices. This toolkit is an ideal tool for clinical trials researchers and community health workers who are interested in learning more …
Table Of Contents
Journal of the South Carolina Academy of Science
No abstract provided.
Effects Of Perfluorooctanoic Acid (Pfoa) And Elevated Salinity On Growth, Reproduction, And Movement Of Physa Acuta, Juana Baudrix, Andrea Rizzo, Samuel Richardson, Jason Doll, Daniel Elias
Effects Of Perfluorooctanoic Acid (Pfoa) And Elevated Salinity On Growth, Reproduction, And Movement Of Physa Acuta, Juana Baudrix, Andrea Rizzo, Samuel Richardson, Jason Doll, Daniel Elias
Journal of the South Carolina Academy of Science
Freshwater ecosystems face increasing threats from pollutants such as perfluorooctanoic acid (PFOA) and elevated salinity. This study examined the effects of PFOA (1.69 µg/L) and elevated salinity (2.5 g/L) on Physa acuta growth, reproduction, and movement over a 21-day exposure. Movement increased across treatments, and reproductive output also increased with salinity and salinity + PFOA, with increased egg sac production in the combined treatment (p < 0.05), while PFOA alone reduced total egg production. Growth was higher with PFOA but decreased in the salinity and salinity + PFOA treatments. Our results suggest that P. acuta increases reproductive output when exposed to combined stressors, prioritizing egg sac production at the cost of movement and growth. These trade-offs may influence P. acuta population dynamics and freshwater ecosystem processes. While this study provides insights into the effects of PFOA and salinity, further research is necessary to understand the long-term ecological consequences in field conditions.
Metabolic Consequences Of Sleep Disorders: A Comprehensive Analysis Of Their Role In Diabetes, Victoria S. Parma
Metabolic Consequences Of Sleep Disorders: A Comprehensive Analysis Of Their Role In Diabetes, Victoria S. Parma
Journal of the South Carolina Academy of Science
The prevalence of type 2 diabetes continues to grow globally, and more strategies are needed to combat this public health problem. Considering the link between sleep problems and risk of type 2 diabetes, the objective of this review is to discuss the experimental and epidemiological evidence underlying the link between sleep disturbances (such as insomnia, circadian rhythm disorders, and obstructive sleep apnea), and the development of insulin resistance and glucose intolerance, which are impairments that can eventually result in type 2 diabetes. In order to explore this, PubMed and Google Scholar were utilized to find pertinent peer-reviewed publications, reviews, and …
Dosimetric Effects Of Pinnacle³ Version 18.0 Advanced Auto-Planning Settings In Oropharyngeal Vmat Optimization, Emily Sanden
Dosimetric Effects Of Pinnacle³ Version 18.0 Advanced Auto-Planning Settings In Oropharyngeal Vmat Optimization, Emily Sanden
Masters Projects
This study evaluated the impact of Pinnacle³ version 18.0 auto-planning advanced settings modulation amount, monitor unit (MU) level, and dose fall-off priority on volumetric modulated arc therapy (VMAT) plan quality for bilateral oropharyngeal cancer. A total of 64 plans were generated using all possible combinations of low, medium, high, and very high settings for each parameter. A standardized base of tongue case was optimized once per plan using a single-time point approach, with planned target volume 1 (PTV1) (6996 cGy) and planned target volume 2 (PTV2) (5412 cGy) coverage evaluated. Each parotid gland, the spinal cord, brainstem, and the oral …
Ai-Based Object Detection And Risk Identification For Enhanced Construction Site Safety, Mahdi Bonyaniakbarabadi
Ai-Based Object Detection And Risk Identification For Enhanced Construction Site Safety, Mahdi Bonyaniakbarabadi
LSU Master's Theses
Recent advancements in computer vision for construction site safety have encountered significant hurdles, especially in the nuanced tasks of object detection and the identification of unsafe worker behaviors. These challenges are often exacerbated by complex and cluttered backgrounds, wide variations in object scale, and inconsistent image quality. While existing methodologies have utilized attention mechanisms to analyze spatial and temporal features, they frequently neglect the benefits of adaptive sampling and channel-wise feature adjustments, thereby failing to exploit potential spatiotemporal redundancies. This thesis introduces a two-pronged approach to address these limitations. First, we propose the Optimized-Position Network (OP-Net), a novel architecture for …
Seven Um Graduates Earn Fulbright Scholarships, Clara Turnage
Seven Um Graduates Earn Fulbright Scholarships, Clara Turnage
University of Mississippi News
OXFORD, Miss. – Seven recent University of Mississippi graduates have a chance to teach English around the world through the Fulbright U.S. Student Program.
Testing The Utility Of The Three Good Things Intervention For Cannabis Misuse Among College Students, Paige Morris
Testing The Utility Of The Three Good Things Intervention For Cannabis Misuse Among College Students, Paige Morris
LSU Doctoral Dissertations
College students experience high rates of cannabis use and use-related problems. Existing brief online interventions for cannabis misuse among college students do not significantly reduce cannabis use and use-related problems relative to control conditions. This may be due to limited consideration of the role of affect, given that cannabis is frequently used for managing affect, especially among individuals with greater depression and social anxiety. The present study sought to improve the efficacy of brief online interventions for cannabis misuse among college students by testing the efficacy of the Three Good Things (3GT; Seligman et al., 2005) intervention, a daily exercise …
Essays On Stablecoins’ Stability, Ravi Joshi
Essays On Stablecoins’ Stability, Ravi Joshi
LSU Doctoral Dissertations
In this dissertation, I present three independent essays that contribute to the literature on stablecoins, the run-on stablecoin (Terra), and the information narrative surrounding the run. The first essay offers a comprehensive overview of the stablecoin ecosystem, the structural frictions that challenge peg maintenance, and the evolving regulatory landscape governing stablecoin issuance and use. In the second essay, I investigate the collapse of the TerraUSD (UST) algorithmic stablecoin and provide evidence that the collapse mimicked a run by demonstrating liquidity shortages on centralized exchanges. I show that Terra’s arbitrage mechanism broke on May 7, 2022, and that sustained price deviations …
The 18s Rrna Methyltransferase Dimt-1 Regulates Lifespan In The Germline Later In Life, M Hafiz Rothi, Gautam Chandra Sarkar, Joseph Al Haddad, Wayne Mitchell, Kejun Ying, Nancy Pohl, Roberto G Sotomayor-Mena, Julia Natale, Scarlett Dellacona, Vadim N Gladyshev, Eric Lieberman Greer
The 18s Rrna Methyltransferase Dimt-1 Regulates Lifespan In The Germline Later In Life, M Hafiz Rothi, Gautam Chandra Sarkar, Joseph Al Haddad, Wayne Mitchell, Kejun Ying, Nancy Pohl, Roberto G Sotomayor-Mena, Julia Natale, Scarlett Dellacona, Vadim N Gladyshev, Eric Lieberman Greer
2020-Current year OA Pubs
Specialized ribosomes help determine which proteins are synthesized, however, the influence of age on ribosome heterogeneity and whether dysregulation of this process drives organismal aging is unknown. Here we examined the role of ribosomal RNA (rRNA) methylation in maintaining appropriate translation as organisms age. In a directed RNAi screen, we identified 18S rRNA N6'-dimethyl adenosine (m
The Biophysical Basis For Karyopherin-Dependent Ebola Virus Vp24 Nuclear Transport, Junjie Zhao, Bojie Zhang, Olivia Vogel, Benjamin W Walker, Leonard W Ma, Nicole D Wagner, Christopher F Basler, Daisy W Leung, Michael L Gross, Gaya K Amarasinghe
The Biophysical Basis For Karyopherin-Dependent Ebola Virus Vp24 Nuclear Transport, Junjie Zhao, Bojie Zhang, Olivia Vogel, Benjamin W Walker, Leonard W Ma, Nicole D Wagner, Christopher F Basler, Daisy W Leung, Michael L Gross, Gaya K Amarasinghe
2020-Current year OA Pubs
Nucleocytoplasmic trafficking is a highly regulated process that allows the cell to control the partitioning of proteins and nucleic acids between the cytosolic and nuclear compartments. The Ebola virus minor matrix protein VP24 (eVP24) hijacks this process by binding to a region on the NPI-1 subfamily of karyopherin alpha (KPNA) nuclear importers. This region overlaps with the activated transcription factor STAT1 binding site on KPNAs, preventing STAT1 nuclear localization and activation of antiviral gene transcription. However, the molecular interactions of eVP24-KPNA5 binding that lead to the nuclear localization of eVP24 remain poorly characterized. Here, we show that trafficking of eVP24 …