Digital Commons Network^™

Genetic Study Of Von Willebrand Factor Antigen Levels ≤ 50 Iu/Dl Identifies Variants Associated With Increased Risk Of Vwd And Bleeding, Rachel K. Friedman, Adam S. Heath, Jennifer E. Huffman, James T. Baker, Natalie R. Hasbani, Sarah A. Gagliano Taliun, Ming-Huei Chen, Tom Howard, Joanne E. Curran, John Blangero

School of Medicine Publications

Background: von Willebrand disease (VWD) is a common inherited bleeding disorder caused by low levels or activity of circulating von Willebrand factor (VWF). Genetic susceptibility to VWF antigen (VWF:Ag) below normal (≤50 IU/dL) in the general population is underexplored.

Methods: To identify genetic variants influencing VWF:Ag levels ≤50 IU/dL, we performed a genome-wide association study in 926 cases with VWF:Ag levels ≤50 IU/dL and 12,846 controls from 7 studies from the TOPMed program. We then examined whether genome-wide significant findings were also associated with clinical diagnosis of VWD in 5 biobanks with 708 VWD cases and 1,286,069 controls, and with …

Ambulatory Blood Pressure Monitoring, European Guideline Targets, And Cardiovascular Outcomes: An Individual Patient Data Meta-Analysis, Dong-Yan Zhang, De-Wei An, Yu-Ling Yu, Jesus D. Melgarejo, José Boggia, Dries S. Martens, Tine W. Hansen, Kei Asayama, Takayoshi Ohkubo, Gladys E. Maestre

School of Medicine Publications

Background and aims: Hypertension is the predominant modifiable cardiovascular risk factor. This cohort study assessed the association of risk with the percentage of time that the ambulatory blood pressure (ABP) is within the target range (PTTR) proposed by the 2024 European Society of Cardiology (ESC) guidelines for blood pressure (BP) management.

Methods: In a person-level meta-analysis of 14 230 individuals enrolled in 14 population cohorts, systolic and diastolic ABPs were combined to assess 24-h, daytime, and nighttime PTTR with thresholds for non-elevated ABP set at < 115/65, < 120/70, and < 110/60 mmHg, respectively.

Results: Median 24-h PTTR was 18% (interquartile range 5-33) corresponding to 4.3 h (1.2-7.9). Over …

Opportunistic Short-Term Water Uptake Dynamics By Subalpine Trees Observed Via In Situ Water Isotope Measurements, Matthias Sprenger, Stefan Seeger, Max Berkelhammer, Nathaniel A. Bogie, Raymond J. Hess, Wendy S. Brown, Sylvain Kuppel, James Knighton

Faculty Research, Scholarly, and Creative Activity

Variations in tree water sources are important to understand in semi-arid ecosystems because climatic shifts towards lower snowpack and increased drought affect water availability in subalpine forests of the western US. Here, we use daily in situ measurements of stable isotopes (²H & ¹⁸O) in soil and tree stem water, soil matric potential and sap flow to study tree water uptake dynamics. We instrumented three soil profiles down to 90 cm, as well as three aspen and engelmann spruce trees near Gothic, Colorado, in the East River watershed. We observed the fate of natural isotopic variations in …

Beyond Peak Water Security: Household-Scale Experiential Metrics Can Offer New Perspectives On Contemporary Water Challenges In The United States, Wendy Jepson, Amber Wutich, Amber L. Pearson, Melissa Beresford, Alexandra Brewis, Alicia Cooperman, Jeremiah Osborne-Gowey, Jenny Rempel, Asher Y. Rosinger, Justin Stoler

Faculty Research, Scholarly, and Creative Activity

The U.S. has moved beyond peak water security. Infrastructural degradation, institutional inertia, and climate change are reducing the ability of households and communities to benefit from near-universal safe, adequate, affordable, sustainable water services. Yet, current supply-side research tools, that focus largely on system performance, are not equipped to measure the prevalence and lived experiences of household water insecurity, thus limiting the evidence available to policymakers, utilities, and communities to make decisions about water services. We discuss how demand-side metrics, such as household-level water insecurity scales validated for high-income contexts, such as the U.S., can help stakeholders to better identify local …

Anticolonialism And Qualitative Methods For Culture-Centered Interventions, Mohan Jyoti Dutta, Ambar Basu, Satveer Kaur-Gill, Debalina Dutta, Mahuya Pal, Iccha Basnyat, Selina Metuamate, Venessa Pokaia, Phoebe Elers, Indranil Mandal, Rabindranath Mandi, Pankaj Baskey, Devalina Mookerjee, Shaunak Sastry, Jaime Robb, Andrew Carter

Faculty Research, Scholarly, and Creative Activity

In this essay, we a collective of Indigenous, Black, and migrant Global South scholars engaged in experiments with the culture-centered approach (CCA) draw on our lived experiences amidst struggles against land grab, neoliberal extractivism, and capitalist exploitation to outline a framework for qualitative methods as anticolonial politics. We begin by exploring the interplays of colonialism, imperialism, and racial capitalism that have shaped the origins and uses of qualitative methods toward serving extractive agendas of global capital. This critique serves as the basis for outlining the key principles of the CCA, turning to voice, storytelling, and embodied action as the basis …

A Protocol For The Development Of A Validated Scale Of Household Water Insecurity In The United States: Hwise-Usa, Amber L. Pearson, Wendy Jepson, Alexandra Brewis, Jeremiah Osborne-Gowey, Amber Wutich, Melissa Beresford, Asher Y. Rosinger, Adam M. Enders, Justin Stoler, Ellis Adjei Adams, Linda Mendez Barrientos, Laura A. Bray, Alida Cantor, Jennifer S. Carrera, Alicia Cooperman, Laura Castro Diaz, Valerisa Magnon Joe Gaddy, Leila M. Harris

Faculty Research, Scholarly, and Creative Activity

Background New metrics of household water insecurity have been validated for low- to middle-income countries, but it is unclear how these measurements apply to the experiences of people living in high-income countries. This project aims to develop and validate a novel metric for household water insecurity experiences in the United States (HWISE-USA) using a cross-sectional design and data from the Southwest, Midwest, and Western regions. Methods We outline the protocol for the development and validation of a novel household water insecurity scale for the United States to address this scientific need, including the following key steps: (1) item development through …

Visual Analog Of Temporal Envelope Benefits Speech Processing In Cochlear Implant Users: A Pilot Functional Near-Infrared Spectroscopy Study On The Associations Between Audiovisual Benefit, Listening Environment, And Peripheral Neural Health, Zi Gao, Yi Yuan, Christopher R. Mueller, Ross A. Aiello, Yingying Wang, Shuman He

Faculty Research, Scholarly, and Creative Activity

Objectives: This study compared the benefit of visual analog of temporal envelope for speech processing across listening environments in postlingually deafened adult cochlear implant users. Associations between cortical activities and peripheral neural health were explored. Design: Speech perception was measured using Harvard/IEEE sentences in quiet and noise with a visually presented sphere whose size was synchronized with the temporal envelope of the sentences. Cortical activities were recorded concurrently using functional near-infrared spectroscopy. Audiovisual benefit was evaluated using sentence scores, activation additivity, and functional connectivity. Peripheral neural health was measured using electrically evoked compound action potentials. Results: Behavioral results showed the …

Electronic Health Record Downtime, Grace R. Baldauf

Electronic Theses and Dissertations

Electronic health record (EHR) downtime presents significant challenges to patient safety and care quality in acute care settings, particularly regarding timely medication administration. This project addressed the problem of late or absent medication doses during planned or unplanned EHR downtime. The investigator aimed to evaluate the effectiveness of a structured downtime plan in improving nurses’ ability to administer medications on time during periods of EHR unavailability. The investigator used a quantitative design to implement a downtime plan evaluation paradigm. Data were collected using retrospective chart reviews of medication administration records pre-implementation and postimplementation of the downtime plan. The sample included …

Institutional Betrayal And Military Vaccine Mandates: An Inquiry Into Loss Of Health Autonomy Concerning Unlimited Liability Contractual Employment In The Covid-19 Era, Aaron G. Dehaven

Electronic Theses and Dissertations

The balance between government control and personal liberty is a growing concern in the modern world. Nowhere is this more evident than in discussions surrounding government policy in public health and individual health autonomy. The Covid-19 pandemic forced many institutions to change their standard operating procedures by adapting to rapidly changing health guidance instituted to protect public health. These changes highlighted the role of health autonomy and individuals’ rights to refuse medical treatments. The Department of Defense changed many aspects of how it operated during the pandemic, including the mandate of the Covid-19 vaccine for all service members. For various …

Consistent Client Simulation For Motivational Interviewing-Based Counseling, Yizhe Yang, Palakorn Achananuparp, Heyan Huang, Jing Jiang, Nicholas Gabriel Lim, Cameron Shi Ern Tan, Phey Ling Kit, Jenny Xiuhui Giam, John Pinto, Ee-Peng Lim

Research Collection School Of Computing and Information Systems

Simulating human clients in mental health counseling is crucial for training and evaluating counselors (both human or simulated) in a scalable manner. Nevertheless, past research on client simulation did not focus on complex conversation tasks such as mental health counseling. In these tasks, the challenge is to ensure that the client’s actions (i.e., interactions with the counselor) are consistent with with its stipulated profiles and negative behavior settings. In this paper, we propose a novel framework that supports consistent client simulation for mental health counseling. Our framework tracks the mental state of a simulated client, controls its state transitions, and …

Developing Targets To Control Multiple Pest Fly Species: Violet Polyester Targets Effectively Attract Tsetse (Diptera: Glossinidae), Stable Flies (Diptera: Muscidae), And House Flies (Diptera: Muscidae), Michael N. Okal, Sheillah J. Akinyi, Roger D. Santer

All Peer-Reviewed Publications

Tsetse (Glossina spp.), stable (Stomoxys spp.), and house flies (Musca domestica L.) impact humans and animals through bites and/or disease transmission. Tsetse are controlled using insecticide-coated fabric targets that are traditionally blue and/or black, but a violet polyester has now been engineered for greater attractiveness. Here, we investigate whether violet targets are also effective against stable and house flies. We sampled flies by electrocution at 1.0 (H) × 0.5 m (W) targets in Kenya, comparing catches at violet targets, and blue and black targets made from polyesters used in commercial traps and targets. Catches of female but not male Glossina …

Invited Review: Effects Of Management On Performance Of Stocker Cattle And Subsequent Feedlot Performance: A Review Within Applied Animal Science, M.A. Snider, M.S. Gadberry, J.D. Rivera

Animal Science Faculty Publications and Presentations

Purpose: The purpose of this review is to summarize relevant research from the journal Applied Animal Science (formerly known as The Professional Animal Scientist) between 1995 and 2024, that explores management practices and concepts as they relate to stocker calf performance and subsequent feedlot performance. A secondary objective of this review is to describe research trends and identify knowledge and research gaps within existing literature. Sources: Sources for this article included peer-reviewed scientific literature obtained from the journal Applied Animal Science, formerly known as The Professional Animal Scientist. Literature used in this review included original research, short communications, technical notes, …

Factors Influencing Healthcare Cybersecurity Effectiveness: An Empirical Investigation, Machuria Mallette Johnson

All Dissertations

The healthcare sector faces escalating cybersecurity risks due to its reliance on electronic health records, legacy systems, medical devices, and health information exchanges. These interconnected technologies expand attack surfaces and create vulnerabilities that threaten patient data, operational continuity, and public trust. These challenges cause many healthcare organizations to struggle to implement effective cybersecurity strategies.

The purpose of this study was to investigate the factors that influence healthcare cybersecurity effectiveness by integrating Institutional Theory, Dynamic Capabilities Theory, Top Management Support, and IT Infrastructure Quality. A survey was administered to healthcare IT, cybersecurity, and executive professionals across the United States. The final …

Axicons For Improved Resolution And Depth Of Focus In Adaptive Optics Scanning Light Ophthalmoscopy, Ruth E. Woehlke, Robert F. Cooper

Biomedical Engineering Faculty Research and Publications

Adaptive optics scanning light ophthalmoscopes are instrumental for studying the eye, yet they use truncated Gaussian illumination and are limited by diffraction, restricting resolution and depth of focus (DOF). Non-diffractive Bessel beams have emerged as an alternative. Here, we use two axicons configured as: (1) an extended DOF beam for resolving multiple retinal layers; and (2) an annular beam for increasing lateral resolution. We compare both approaches to truncated Gaussian illumination using a variety of metrics. Using Configuration 1, we successfully observed multiple retinal layers simultaneously. Using Configuration 2, we observed enhanced lateral resolution but decreased signal-to-noise ratio.

School Counselor Burnout And Self-Efficacy And Their Impact On The Degree Of Implementation Of A Comprehensive School Counseling Program, Rebecca Pierre-Louis

Counseling & Human Services Theses & Dissertations

School Counselors are educators who are vital in supporting students’ educational development. School Counselors do this by delivering a comprehensive, developmentally appropriate, and prevention-oriented school counseling programs that provide direct, indirect, and responsive services to support students’ career, academic, and social/emotional development. School Counselors do this while often experiencing an expanded definition of their role within a school building. While research supports the benefits of comprehensive school counseling programs to schools and students, school counselors often face large student caseloads. As well, they are tasked with many non-school counseling duties, which hampers the delivery of a comprehensive school counseling program. …

Advanced Analytical Biosensing For Cancer Detection And Neural Diagnostics Using Tapered Optical Fiber (Tof), Protonic, And High Throughput Microplate –Based Technologie, Bayan Hassan Alharbi

Chemistry & Biochemistry Theses & Dissertations

This dissertation investigates the development and application of advanced biosensing technologies to enhance early disease detection, neurological diagnostics, and bioactive compound evaluation. The research spans four key areas. First, it introduces tapered optical fiber (TOF)-based plasmonic biosensors for the non-invasive detection of prostate cancer, demonstrating high sensitivity and specificity compared to conventional diagnostic methods.

Second, it explores the use of fluorescent biosensors to test the Transmembrane Electrostatically Localized Proton (TELP) theory, shedding light on the role of localized protons in neuronal signaling and energy transfer. Third, the work presents a high-throughput, microplate-based biosensing platform for analyzing mitochondrial function under nanosecond …

Empowering The User Through Inclusive Technical Writing, Robert Enriquez

English Theses & Dissertations

This thesis examines the issues in technical writing due to a disconnect between writer and reader/user. I am basing this study on my real-life job. I am a manager at a well-known sneaker retailer. In August 2024, there was a Workforce Management (WFM) software that the sneaker retailer launched in the retail stores. The WFM itself was glitched and unfinished. Not much disclaimer, training or preparation was given other than these procedural documents the sneaker retailer gave. If all the store managers had to depend on was technical documentation to prepare for this already glitched WFM, then I argue there …

Good And Safe: Exploring The Impact Of Mindfulness And Primal World Beliefs On Psychological Well-Being, Katelyn J. Haschke

Psychology Theses & Dissertations

Dispositional mindfulness refers to the ability to intentionally focus on the present moment, which positively affects psychological well-being (PWB). Mindfulness can be practiced through formal interventions—such as meditation or body scan, where individuals engage in structured activities to cultivate awareness—or informal practices, such as focusing on one task at a time where mindfulness is integrated into routine activities. A person’s phenomenological perspective, shaped by their core beliefs about the world (primals), also influences PWB. For instance, those who view the world as mostly safe or good may be more likely to form close relationships and engage more deeply with their …

Intersecting Realities And Evolving Landscapes: Mapping Generative Ai Within The Framework Of Digital Rhetoric, Joshua Troy Nieubuurt

English Theses & Dissertations

The increased usage of [Generative] AI technologies (GenAI) in the 21st century has called into the question the rhetorical agency of these digital things. [Gen]AI has historically been framed within a Heideggerian “readiness-to-hand” dynamic in which it has been unilaterally conceived as a tool to be used by humans. This dissertation proposes that the GenAI assemblage is capable of being a co-actor in rhetorical spaces. To provide evidence for this stance This dissertation utilizes Actor Network Theory to map the actants within a GenAI assemblage. In doing so it allows for an understanding of the stakeholders (both human and non-human) …

Systems Statistical Engineering – Hierarchical Fuzzy Constraint Propagation, Hengameh Fakhravar

Engineering Management & Systems Engineering Theses & Dissertations

Driven by the growing need in the 21st century for integrating rigorous statistical analysis into engineering research, there is a movement to develop an integrated statistical engineering science within statistics and quality communities (Hoerl & Snee, 2010; Anderson-Cook et al., 2012). Systems Statistical Engineering research seeks to integrate the Causal Bayesian hierarchical modeling (Pearl, 2009) and cybernetic control theory within Beer’s Viable System Model (1972, 1979, 1985) and the Complex Systems Governance framework (Keating, 2014; Keating & Katina, 2015, 2016) to produce multivariate systemic models for robust dynamic systems mission performance. Cotter & Quigley (2018) set forth the Bayesian systemic …

Effects Of Sediment Composition On Spartina Alterniflora And Juncus Roemerianus Productivity In Coastal Virginia: A Thin-Layer Sediment Placement Experiment, Caitlin Hemphill

Biological Sciences Theses & Dissertations

Climate change poses a major threat to the health of estuaries and their coastal wetland systems. The Chesapeake Bay’s coastal salt marshes are at high risk of inundation due to sea-level rise and land subsidence. Restoration techniques for maintaining coastal marsh resistance to sea-level rise are being developed and refined, with thin layer placement (TLP) emerging as a feasible solution in many areas of the United States. Despite TLPs use across the country, additional research is needed on species-specific responses, sediment types, and geographically focused studies in the lower Chesapeake Bay. My research addresses these gaps by combining both greenhouse …

A Three-Stage Matheuristic For The Blood Stochastic Inventory Routing Problem, Vincent F. Yu, Nabila Salsabila, Aldy Gunawan, Aldy Gunawan, Nurhadi Siswanto

Research Collection School Of Computing and Information Systems

This research introduces a blood distribution system under vendor-managed inventory that considers uncertain supply and demand. We present it as the Blood Stochastic Inventory Routing Problem, formulating it as a two-stage stochastic programming model. To solve this problem, this study proposes a three-stage matheuristic that combines a perturbation heuristic, Adaptive Large Neighborhood Search, and an exact approach. From historical data of Surabaya Blood Center in Indonesia, six sets of new instances are generated under different settings. Computational results show that our proposed three-stage matheuristic outperforms CPLEX and a two-stage matheuristic by gaining optimal or better solutions within a significantly shorter …

Learning Frame-Level Classifiers For Video-Based Real-Time Assessment Of Stroke Rehabilitation Exercises From Weakly Annotated Datasets, Ana Rita Cóias, Min Hun Lee, Alexandre Bernardino, Asim Smailagic, Mariana Mateus, David Fernandes, Sofia Trapola

Research Collection School Of Computing and Information Systems

Autonomous rehabilitation support solutions, such as virtual coaches, should provide real-time feedback to improve motor function and maintain patient engagement. However, fully annotated dataset collection for real-time exercise assessment is time-consuming and costly, posing a barrier to evaluating proposed methods. In this work, we present a novel framework that learns a frame-level classifier using weakly annotated videos for real-time assessment of compensatory motions in stroke rehabilitation exercises by generating pseudo-labels at a frame level. We consider three approaches: 1) a baseline approach that uses a source dataset to train a frame-level classifier, 2) a transfer learning approach that uses target …

Ai-Assisted Triage And Decision Support Of Head And Neck Cancer Screening And Diagnosis In Low-Resourced Settings, Min Hun Lee, Sean Shao Wei Lam, Shaun Xin Hong Liew, Michael Dorosan, Nicholas Graves, Jonas Karlström, Hiang Khoon Tan, Walter Tsong Lee

Research Collection School Of Computing and Information Systems

The mortality burden of head and neck cancer (HNC) is increasing globally and disproportionately affects people in low-and middle-income countries with limited medical workforce. To address this issue, artificial intelligence (AI) algorithms are increasingly being explored to process medical imaging data, demonstrating competitive performance. However, the clinical adoption of AI remains challenging as clinicians struggle to understand how complex AI works and trust it to use in practice. In addition, AI may not perform well on varying data qualities of endoscopy videos for HNC screening and diagnosis from multiple sites.In this project, our international and interdisciplinary team will collaborate with …

Colloquial Singaporean English Style Transfer With Fine-Grained Explainable Control, Jinggui Liang, Dung Vo, Yap Hong Xian, Hai Leong Chieu, Kian Ming A. Chai, Jing Jiang, Lizi Liao

Research Collection School Of Computing and Information Systems

Colloquial Singaporean English (Singlish) is an informal English marked by a unique blend of languages reflecting Singapore’s multicultural identity. Style transfer between Singlish and Standard (formal) English is vital for various applications, yet existing methods often lack explainability and fine-grained control. To fill this gap, we contribute in two key ways. First, we construct a large, high-quality dataset of formal and informal sentences, annotated across six linguistic aspects—Syntax, Lexical Borrowing, Pragmatics, Prosody/Phonology, Emoticons/Punctuation, and Code-Switching—with detailed explanations. Starting with manually annotated cases, we scaled the dataset to 140K with ensured quality. Second, inspired by the “Society of Mind” theory, we …

Inference-Time Gaze Refinement For Micro-Expression Recognition: Enhancing Event-Based Eye Tracking With Motion-Aware Post-Processing, Panahetipola Mudiyanselage Nuwan Bandara, Thivya Kandappu, Archan Misra

Research Collection School Of Computing and Information Systems

Event-based eye tracking holds significant promise for fine-grained cognitive state inference, offering high temporal resolution and robustness to motion artifacts, critical features for decoding subtle mental states such as attention, confusion, or fatigue. In this work, we introduce a model-agnostic, inference-time refinement framework designed to enhance the output of existing event-based gaze estimation models without modifying their architecture or requiring retraining. Our method comprises two key post-processing modules: (i) Motion-Aware Median Filtering, which suppresses blink-induced spikes while preserving natural gaze dynamics, and (ii) Optical Flow-Based Local Refinement, which aligns gaze predictions with cumulative event motion to reduce spatial jitter and …

Effect Of Amino Acid Derivatives And Polyphenol Supplementation On Skeletal Muscle Growth In-Vitro And In-Vivo, Gabriella C. Iheanacho

All Theses

Background

Satellite cells (SCs) are myogenic precursor cells that play a crucial role in muscle growth, and their activity can be influenced by nutrient supplementation. Muscle growth can also be stimulated using growth-promoting hormones; however, there are no approved growth hormones for use in sheep in the United States (Qaid & Abdoun, 2022). This limitation highlights a need to identify alternative compounds that would serve as nutrient supplements to enhance muscle growth and thereby improve meat production. Amino acid derivatives such as guanidinoacetic acid (GAA) and 5-hydroxytryptophan (5-HTP), along with the polyphenol quercetin, are naturally derived compounds that have shown …

Computational Study Of Nonlinear Electrokinetic Phenomena In Shear-Thinning Fluids, Wai Yuen Leung

All Theses

Electrokinetic phenomena have been widely used for fluid pumping and particle manipulation in micro/nanofluidic systems. They refer to the motion of fluids or particles in response to an electric field because of the spontaneous formation of an electric double layer at the fluid-solid interface. Understanding electrokinetic phenomena in micro/nanochannels is critical for a wide range of applications across various engineering fields, such as disease diagnostics, contaminant treatment and cell analysis. To date, numerous studies have been reported on electrokinetic phenomena in Newtonian fluids, where the classical Helmholtz-Smoluchowski theory indicates a linear relationship between fluid electroosmosis/particle electrophoresis and electric field. However, …

Machine Learning Based Medical Ultrasound Image Classification And Grad-Cam Interpretation, Victoria C. Hemphill

All Theses

This work takes a step in creating a diagnostic tool for the classification decision process of Achilles tendinopathy using ultrasound images. An attention-based multiple instance learning model is developed to classify the images. Typically, doctors capture multiple ultrasound images of the Achilles tendon during a study to determine a complete diagnosis. Multiple instance models adopt this behavior by providing a single label for a set of instances (images). The images are grouped into ”bags” at the study level and passed into the model. The MIL model then uses its attention property to assign an importance score to each image to …

Visor-Zt: A Visibility, Simulation, And Operational Resilience Framework For Zero Trust Security In Ros 2, Noah Tinker

All Theses

Robotic systems are becoming more and more prevalent in modern society, with Robot Operating System 2 (ROS 2) being the dominant operating system for these implementations. Its popularity can be attributed to its design, which is purpose-built for distributed systems and asynchronous communications. However, ROS 2 security is static and therefore less capable of responding to contemporary threats and network behavior. This becomes a greater issue when considering its applications in the military and defense sectors, where security is of the highest importance. In recent years, the U.S. Department of Defense (DoD) has implemented zero trust (ZT) security based on …