Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (326225)
- Social and Behavioral Sciences (259467)
- Law (183275)
- Education (154022)
- Arts and Humanities (123248)
-
- Life Sciences (116495)
- Medical Specialties (77144)
- Physical Sciences and Mathematics (64912)
- Higher Education (59385)
- Public Health (55696)
- Business (51313)
- History (50487)
- Psychology (48893)
- Medical Sciences (45267)
- Sociology (44002)
- Communication (43627)
- Engineering (41102)
- Nursing (34192)
- Public Affairs, Public Policy and Public Administration (33235)
- Library and Information Science (25740)
- Environmental Sciences (24959)
- Religion (21836)
- United States History (21835)
- Diseases (21765)
- Journalism Studies (21680)
- Mass Communication (21326)
- Economics (18010)
- Educational Administration and Supervision (18004)
- Rehabilitation and Therapy (16651)
- Social History (16395)
- Institution
-
- University of New Mexico (56072)
- University of New Hampshire (43700)
- University of Nebraska - Lincoln (37650)
- University of Montana (27880)
- The Texas Medical Center Library (27510)
-
- University of Colorado Law School (24806)
- University of Mississippi (24700)
- University of South Florida (22929)
- Murray State University (21735)
- Washington University School of Medicine (20231)
- University of Kentucky (18292)
- Georgia Southern University (18177)
- San Jose State University (17421)
- Chulalongkorn University (17318)
- Walden University (16849)
- Utah State University (16524)
- Western Kentucky University (16401)
- Thomas Jefferson University (16394)
- Western Michigan University (16145)
- Gallaudet University (15146)
- Eastern Illinois University (15079)
- Sigma Theta Tau International Honor Society of Nursing (14747)
- Nova Southeastern University (14547)
- University of Central Florida (14426)
- University of Alabama at Birmingham (14418)
- Virginia Commonwealth University (14284)
- University of North Dakota (14258)
- California Polytechnic State University, San Luis Obispo (13719)
- Brigham Young University (12773)
- Bowling Green State University (12540)
- Keyword
-
- Newspaper (30168)
- Humans (28572)
- Female (13601)
- Education (13407)
- COVID-19 (12866)
-
- Student newspaper (12365)
- Male (11840)
- Newspapers (10319)
- Newsletter (9999)
- Animals (9219)
- Bowling Green State University (8945)
- Spartan Daily (8774)
- EIU (8524)
- Michigan (7935)
- History (7331)
- United States (7298)
- Higher education (7292)
- Eastern Illinois University (7250)
- Daily Eastern News (7142)
- Adult (7043)
- BG News (7010)
- Faculty (6315)
- N.M. (6305)
- Mental health (6230)
- Pennsylvania (6209)
- B.G. News (5981)
- Mice (5910)
- Collegeville (5821)
- Middle Aged (5780)
- Students (5688)
- Publication Year
-
- 2026 (49320)
- 2025 (75696)
- 2024 (79574)
- 2023 (77322)
- 2022 (76362)
-
- 2021 (76678)
- 2020 (74490)
- 2019 (65574)
- 2018 (62001)
- 2017 (60668)
- 2016 (57413)
- 2015 (53355)
- 2014 (48977)
- 2013 (45582)
- 2012 (44658)
- 2011 (38432)
- 2010 (35762)
- 2009 (32225)
- 2008 (29313)
- 2007 (26436)
- 2006 (24613)
- 2005 (22455)
- 2004 (20430)
- 2003 (18915)
- 2002 (17907)
- 2001 (16948)
- 2000 (16447)
- 1999 (15100)
- 1998 (14752)
- 1997 (14302)
- Publication
-
- Theses and Dissertations (30814)
- Walden Dissertations and Doctoral Studies (15656)
- Electronic Theses and Dissertations (15365)
- Faculty Publications (14391)
- Faculty, Staff and Student Publications (13689)
-
- Dissertations (12717)
- Session Laws 1951-2000 (12443)
- Faculty Scholarship (10234)
- Spartan Daily (School of Journalism and Mass Communications) (8078)
- Faculty, Staff and Students Publications (7785)
- Daily Mississippian (all digitized issues) (7637)
- Articles (7470)
- 2020-Current year OA Pubs (7430)
- Open Access Publications (7412)
- BG News (Student Newspaper) (7107)
- Santa Fe New Mexican, 1883-1913 (6966)
- Master's Theses (6844)
- Montana Kaimin, 1898-present (6764)
- Theses (6566)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (6481)
- Browse All News (6430)
- Masters Theses (6389)
- The Murray Ledger & Times (6370)
- Honors Theses (5931)
- Doctoral Dissertations and Projects (5817)
- Session Laws 2001-Present (5710)
- USF Tampa Graduate Theses and Dissertations (5473)
- International Nursing Research Congress (INRC) (5330)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (5148)
- Saudi Medical Journal (5073)
- Publication Type
Articles 72301 - 72330 of 1793363
Full-Text Articles in Entire DC Network
How Much Has The Recognition Of Women Artists’ Contributions To Art History Changed In The Past Half Century And Why?, Roger Clark
How Much Has The Recognition Of Women Artists’ Contributions To Art History Changed In The Past Half Century And Why?, Roger Clark
Sociology Between the Gaps: Forgotten and Neglected Topics
No abstract provided.
Three Essays In International Trade And Macroeconomics, Jun Nie
Three Essays In International Trade And Macroeconomics, Jun Nie
Economics Theses and Dissertations
This dissertation examines the impact of international trade and trade policy on key economic outcomes, including income and productivity. The first chapter investigates the role of trade-induced technology diffusion in shaping global income inequality. When bilateral trade facilitates technology transfer, such diffusion can account for up to 85% of the income gap across countries. The second chapter focuses on the determinants of international trade in services. It highlights a significant link between service and manufacturing trade, conditional on the presence of foreign direct investment (FDI) relationships between trading partners. The third chapter evaluates the 2020 U.S. presidential election, aiming to …
Leadership Self-Efficacy: Exploring Social Workers’ Perceived Ability To Serve On School Boards, Jessica Zavalza
Leadership Self-Efficacy: Exploring Social Workers’ Perceived Ability To Serve On School Boards, Jessica Zavalza
Walden Dissertations and Doctoral Studies
The low representation of social workers serving on school boards is a social work practice problem because it limits their leadership ability to advocate for student mental health and influence policy change at the local and state levels of education. Therefore, addressing this practice problem within the context of clinical social work is crucial for improving student mental health outcomes and overall student well-being. Guided by Bandura’s self-efficacy theory, this qualitative study was conducted to explore the connection between social workers’ leadership self-efficacy and their willingness to pursue policymaking roles at the local and state school board levels. With the …
Statistical Methods For Joint Outcome Modeling And Dynamic Assessment Of Recurrent Events, Zifang Kong
Statistical Methods For Joint Outcome Modeling And Dynamic Assessment Of Recurrent Events, Zifang Kong
Statistical Science Theses and Dissertations
Recurrent event data frequently arise in clinical studies where individuals experience repeated, possibly related, events over time. These data are often accompanied by sparse and irregular longitudinal measurements, creating challenges for traditional joint modeling approaches that struggle to account for time-dependent associations and within-subject correlations. We propose FRAILTY (Functional Regression with AutoRegressIve fraiLTY), a novel two-step framework that integrates functional principal component analysis (PACE) with a dynamic frailty model featuring autoregressive structure. FRAILTY accommodates both scalar and functional predictors and captures within-subject dependence across recurrent events. To further extend its utility, we develop a multivariate joint modeling framework that simultaneously …
Towards Reliable Clinical Applications Of Ai Models In Radiotherapy, Biling Wang
Towards Reliable Clinical Applications Of Ai Models In Radiotherapy, Biling Wang
Statistical Science Theses and Dissertations
Over the past decade, artificial intelligence (AI), particularly through deep learning (DL) techniques, has made significant strides in fields like computer vision (CV) and natural language processing (NLP), leading to transformative advancements across numerous applications. This progress has sparked considerable enthusiasm within the medical field, where DL-related research has grown exponentially since 2015. However, despite these promising developments, the real-world deployment of DL models in healthcare remains limited, especially in safety-critical domains such as radiotherapy (RT), where reliability, safety, and sustained performance are critical. This thesis addresses three core challenges associated with the clinical application of DL models: (1) post-deployment …
Establishing Operational Foundations In A Faculty-Led Clinic: Workflow Design, Role Development, And Service Planning, Rebecca Wensmann
Establishing Operational Foundations In A Faculty-Led Clinic: Workflow Design, Role Development, And Service Planning, Rebecca Wensmann
DNP Projects
A Central Minnesota College, in collaboration with local community partners, sought to provide access to medical care for an underserved population while offering opportunities for graduate and undergraduate nursing education. They achieved this by establishing a faculty-led clinic in a high-poverty level area in Central Minnesota, where nearly 7% of the population under the age of 65 lacked health insurance (U.S. Census Bureau, 2024). Research was completed on clinic workflows and processes, as well as many interviews with clinics and community members throughout Minnesota. With this data, a clinic workflow, job description list, and services offered were created. This information …
A Dosimetric Comparison Of 6 Mv And 10 Mv Beam Energies For Adrenal Sbrt, Mariel A. Lewis
A Dosimetric Comparison Of 6 Mv And 10 Mv Beam Energies For Adrenal Sbrt, Mariel A. Lewis
Masters Projects
Purpose This study aims to compare the dosimetric performance of 6 MV and 10 MV photon beam energies in stereotactic body radiation therapy (SBRT) for adrenal tumors. Given the anatomical complexity of the adrenal region and its proximity to critical organs, optimizing beam energy selection is essential to maximize tumor control while minimizing normal tissue toxicity. Methods and Materials A retrospective study analysis was conducted using treatment plans from ten patients with adrenal metastases. Each case was planned with volumetric modulated arc therapy (VMAT) using both 6 MV and 10 MV beam energies. Dosimetric metrics assessed included target coverage, conformity …
Improving Medication Adherence Among Patients With Anxiety, Abong Miyeh
Improving Medication Adherence Among Patients With Anxiety, Abong Miyeh
Walden Dissertations and Doctoral Studies
Addres+D14sing medication non-adherence among patients with anxiety disorders is crucial in nursing practice due to its significant impact on patient outcomes and healthcare costs. This doctoral project explores the effectiveness of staff education in enhancing nurses' skills in promoting medication adherence within this population. The practice-focused question for this project is "What evidence supports the effectiveness of a staff education program in increasing nursing staff knowledge about evidence-based strategies for improving medication adherence among patients with anxiety disorders?" The purpose of this doctoral project is to investigate the effectiveness of staff education interventions in improving medication adherence among individuals with …
Faculty And Administrators' Perspectives Of Generative Artificial Intelligence At An Online Higher Education Institution, Devon Edmund
Faculty And Administrators' Perspectives Of Generative Artificial Intelligence At An Online Higher Education Institution, Devon Edmund
Walden Dissertations and Doctoral Studies
The problem addressed in this study was that faculty and administrators in higher education are not prepared to address the use of generative artificial intelligence (GAI) innovations in institutional policies and practices. The pace of advancement of GAI in higher education (HE) left institutions to determine policies and practices without industry best practices or guidelines established by accreditors or regulatory bodies. The purpose of this qualitative study was to explore the perspectives of faculty and administrators at an online HE institution on how to respond to the emergence of GAI through institutional policies and practices. The theory supporting the study …
The Benefits Of High Phosphate Concentration (10n : 1p) And Diagonal Orientation On The Ex Situ Grow-Out Of Caribbean Coral Juveniles, Ashley Shen
All HCAS Student Capstones, Theses, and Dissertations
As coral reefs keep declining, it is imperative to increase coral production ex situ for restoration, but this requires culture protocols to be optimized. This study examined the impacts of grow-out orientation and phosphate concentration (and nitrate (N): phosphate (P) ratio) on the survival and growth of Montastraea cavernosa and Pseudodiploria clivosa juveniles from 3 to 9 months old. Pristine reefs typically have low nitrate (0.12μmol/L) and low phosphate (0.03μmol/L) concentrations, leading to N:P ratios of 4-16 N: 1P. In recirculating tanks, it is difficult to lower nitrate concentrations below 25μmol/L. Here we hypothesized that increasing the phosphate concentration in …
Staff Education To Improve Staff Knowledge On Preeclampsia, Doris Wanmban Fombo
Staff Education To Improve Staff Knowledge On Preeclampsia, Doris Wanmban Fombo
Walden Dissertations and Doctoral Studies
Preeclampsia is a disorder that usually develops after 20 weeks of pregnancy and can lead to serious adverse outcomes or death for the mother and fetus if not promptly diagnosed and managed. Hence, a staff education project was designed and implemented to enhance staff knowledge of preeclampsia. The practice problem was limited staff knowledge of preeclampsia a pregnancy complication that can affect both the mother and fetus. The practice-focused question explored whether a staff education project on preeclampsia affected office staff knowledge. The purpose of the project was to develop and implement a staff education program to improve staff knowledge …
Rare Variants In Bmal1 Are Associated With A Neurodevelopmental Syndrome, Vishnu Anand Cuddapah, Dechun Chen, Bumsik Cho, Rebecca Moore, Mohnish Suri, Hana Safraou, Frederic Tran-Mau-Them, Ashley Wilson, Jacqueline Odgis, Atteeq U. Rehman, Carol J. Saunders, Shiva Ganesan, Vaidehi Jobanputra, Stephen W. Scherer, Ingo Helbig, Amita Sehgal
Rare Variants In Bmal1 Are Associated With A Neurodevelopmental Syndrome, Vishnu Anand Cuddapah, Dechun Chen, Bumsik Cho, Rebecca Moore, Mohnish Suri, Hana Safraou, Frederic Tran-Mau-Them, Ashley Wilson, Jacqueline Odgis, Atteeq U. Rehman, Carol J. Saunders, Shiva Ganesan, Vaidehi Jobanputra, Stephen W. Scherer, Ingo Helbig, Amita Sehgal
Manuscripts, Articles, Book Chapters and Other Papers
Through international gene-matching efforts, we identified 10 individuals with ultrarare heterozygous variants, including 5 de novo variants, in BMAL1, a core component of the molecular clock. Instead of an isolated circadian phenotype seen with disease-causing variants in other molecular clock genes, all individuals carrying BMAL1 variants surprisingly share a clinical syndrome manifest as developmental delay and autism spectrum disorder, with variably penetrant sleep disturbances, seizures, and marfanoid habitus. Variants were functionally tested in cultured cells using a Per2-promoter driven luciferase reporter and revealed both loss-of-function and gain-of-function changes in circadian rhythms. The tested BMAL1 variants disrupted PER2 mRNA …
Supporting Young Learners With Disabilities In Inclusive Classrooms: A Toolkit For General Education Teachers, Emily M. Raleigh
Supporting Young Learners With Disabilities In Inclusive Classrooms: A Toolkit For General Education Teachers, Emily M. Raleigh
Masters Projects
Many young elementary students with disabilities often experience difficulty maintaining engagement in their learning and managing their emotions in general education classrooms. These challenges can have a negative influence on their ability to interact with their peers, develop foundational academic skills, and feel a sense of belonging. At the same time, many general educators report a lack of effective training, strategies, and confidence in implementing supports to students with disabilities, particularly in the areas of self-regulation and engagement. This project responds to this issue through the creation of a visual support toolkit developed for use in inclusive early elementary classrooms. …
Comparison Of 10 Mv Flattening Filter And Flattening Filter-Free Volumetric Modulated Art Therapy (Vmat) Radiation Plans In Partial Breast Irradiation: Evaluating Dose Sparing To The Left Anterior Descending Coronary Artery, Jillian Beliew
Masters Projects
Importance Minimizing radiation dose to the heart, particularly the left anterior descending coronary artery (LAD), is essential in left-sided partial breast irradiation (PBI). Flattening filter-free (FFF) beam configurations may improve organ-at-risk (OAR) sparing and treatment efficiency.
Objective To compare dosimetric outcomes between 10 MV flattening filter (FF) and 10 MV flattening filter-free (FFF) VMAT plans in patients receiving accelerated partial breast irradiation (APBI), focusing on LAD dose sparing.
Design, Setting, and Participants This retrospective dosimetric study included 10 patients with early-stage, left-sided breast cancer. Each patient had two VMAT plans generated using identical geometry and constraints in Eclipse v16.01: one …
A Call To Action To Include Disability In Intersectional Health Equity Research And Policy, Susan M. Havercamp, Gloria L. Krahn, Alexa J. Murray, Ilhom Akobirshoev, Chyrell D. Bellamy, Alexandra Bonardi, Mary Lou Breslin, Ly Xīnzhèn Zhǎngsūn Brown, Mark Costa, Marjorie Mcgee, Multiple Additional Authors
A Call To Action To Include Disability In Intersectional Health Equity Research And Policy, Susan M. Havercamp, Gloria L. Krahn, Alexa J. Murray, Ilhom Akobirshoev, Chyrell D. Bellamy, Alexandra Bonardi, Mary Lou Breslin, Ly Xīnzhèn Zhǎngsūn Brown, Mark Costa, Marjorie Mcgee, Multiple Additional Authors
School of Social Work Faculty Publications and Presentations
Summary:
Disability status is rarely included in health research and policy, including intersectional research, perpetuating health inequities for this population. This paper calls on researchers and policymakers to take concrete steps to advance health equity for disabled people, including those at the intersections of disability, race, ethnicity, poverty, and other marginalized identities. We propose four strategies with recommendations to promote: a) meaningful engagement of disabled and multiply marginalized people in research and policy planning; b) cohesive, systemic disability data collection and analyses; c) use of intersectional approaches to examine structural drivers of health inequities; and d) leveraging of administrative data …
Method For Target Detection In A High Noise Environment Through Frequency Analysis Using An Event-Based Vision Sensor, Will Johnston, Shannon Young, David Howe, Rachel Oliver, Zachary Theis, Brian Mcreynolds, Michael L. Dexter
Method For Target Detection In A High Noise Environment Through Frequency Analysis Using An Event-Based Vision Sensor, Will Johnston, Shannon Young, David Howe, Rachel Oliver, Zachary Theis, Brian Mcreynolds, Michael L. Dexter
Faculty Publications
Event-based vision sensors (EVSs), often referred to as neuromorphic cameras, operate by responding to changes in brightness on a pixel-by-pixel basis. In contrast, traditional framing cameras employ some fixed sampling interval where integrated intensity is read off the entire focal plane at once. Similar to traditional cameras, EVSs can suffer loss of sensitivity through scenes with high intensity and dynamic clutter, reducing the ability to see points of interest through traditional event processing means. This paper describes a method to reduce the negative impacts of these types of EVS clutter and enable more robust target detection through the use of …
Implementation Of A Standardized Onboarding Program, Sarah J. Wall
Implementation Of A Standardized Onboarding Program, Sarah J. Wall
Doctor of Nursing Practice Final Project Abstract
Purpose: To evaluate the impact of a standardized onboarding program on Advanced Practice Provider (APP) retention and productivity within an academic department.
Background: High APP turnover in specialized settings disrupts care and leads to financial losses. Previously, onboarding lacked structure, leading to early attrition and delayed productivity. A 24-week phased, competency-based orientation program was developed to improve retention, job satisfaction, and clinical performance.
Methods: The program, implemented in April 2024, included clinical precepting, didactic modules, and mentorship. Retention and Relative Value Units (RVUs) were measured before and after implementation. Qualitative data was collected through mentorship surveys and APP focus groups. …
Opening The Black-Box Of Mental Disorders: An Actor-Network Theory Analysis Of Schizophrenia, Brandalyn Morris
Opening The Black-Box Of Mental Disorders: An Actor-Network Theory Analysis Of Schizophrenia, Brandalyn Morris
McNair Scholars Manuscripts
Schizophrenia is a poorly understood mental dysfunction. It is culturally specific and encompasses several disease entities that defy robust classification. Using a few of the methodological notions from Bruno Latour’s Actor-Network Theory (ANT), this research seeks to disambiguate schizophrenia. The scope and focus of this examination will be restricted to three actors/actants within the assemblage of this mental disorder. By appropriating tools and terminology from ANT to reveal human and non-human actors and actants within the DSM classification system, the medical model of mental illness, and psychopharmacology, the objective of this research is to describe how the current concept of …
The Emergence Of An Object Of Regulatory Concern: The European Union’S Artificial Intelligence Act, Galán, Alexis, Schmidt, Rebecca
The Emergence Of An Object Of Regulatory Concern: The European Union’S Artificial Intelligence Act, Galán, Alexis, Schmidt, Rebecca
Santa Clara Journal of International Law
No abstract provided.
Acquisitions Unit Annual Report 2024-2025, Andrée J. Rathemacher
Acquisitions Unit Annual Report 2024-2025, Andrée J. Rathemacher
Technical Services Reports and Statistics
Annual Report of the Acquisitions Unit, University Libraries, University of Rhode Island for FY2025. Covers personnel, work flow, special projects, and serial, monograph, and e-resource acquisitions. Supplemental files include data on library materials expenditures by a number of variables as well as important working documents from the year.
Recreation Effects On Soil Carbon, Biocrust Presence, Soil Stability, And Invasive Species In Indian Creek, Bears Ears National Monument, Elisabeth M. Currit
Recreation Effects On Soil Carbon, Biocrust Presence, Soil Stability, And Invasive Species In Indian Creek, Bears Ears National Monument, Elisabeth M. Currit
Theses and Dissertations
Desert ecosystems perform essential ecosystem services, including playing a crucial role in the global carbon cycle. Because of this, it is important to understand how recreational activities, common in desert environments, impacts dryland ecosystems' ability to perform ecosystem services. The growing popularity of outdoor recreation in Western US poses a threat to desert ecosystems, and unregulated activities can harm soil health, particularly the presence and functioning of biological soil crusts (biocrusts). This study uses the Indian Creek Special Recreation Management area in Bears Ears National Monument, Utah, USA, as a case study for recreation impacted desert ecosystems. It examines the …
Consequences Of The Double Empathy Problem Within The Clinical Environment: A New Model For Neuroinclusive Care, Sofia Jimenez
Consequences Of The Double Empathy Problem Within The Clinical Environment: A New Model For Neuroinclusive Care, Sofia Jimenez
Theses and Dissertations
As diagnoses of autism spectrum disorder (ASD) rise, the neurodiversity and autistic self-advocacy movements have challenged traditional deficit-based clinical models and called for more inclusive, affirming approaches to care. Recent research disputes the long-held belief that autistic individuals have deficits in perspective-taking, revealing that miscommunication between autistic and neurotypical individuals results from mutual misunderstanding, a concept known as the double empathy problem (DEP; Milton, 2012), with the triple empathy problem (TEP) extending this framework to healthcare settings. Our study investigates the consequences of the DEP and TEP within clinical environments, focusing on interactions between neurotypical speech-language pathologists (SLPs) and adult …
Exploring Soil-Derived Antimicrobials For Inhibiting Dairy-Associated Pathogens And Spoilage Bacteria, Michael Joseph Moran
Exploring Soil-Derived Antimicrobials For Inhibiting Dairy-Associated Pathogens And Spoilage Bacteria, Michael Joseph Moran
Theses and Dissertations
Spore-forming bacteria are among the most problematic contaminants in fluid milk. They can survive pasteurization, grow at refrigeration temperatures, and secrete heat-stable enzymes, making them a major cause of spoilage in both pasteurized and reconstituted milk products. Current nonthermal strategies for reducing spore counts, including microfiltration and bactofugation, are often costly and inconsistent. The increasing consumer demand for natural additives in food products has sparked interest in the use of bacterially-derived antimicrobial compounds, particularly those from generally recognized as safe (GRAS) organisms, as an alternative method of dairy preservation. This study explores the antimicrobial potential of ten soil-derived Bacillus and …
Perspectives On Career Advising At A Large Private Religious Institution, Lane Toshio Muranaka
Perspectives On Career Advising At A Large Private Religious Institution, Lane Toshio Muranaka
Theses and Dissertations
This study examines the role of career advising at Brigham Young University (BYU), a faith-based institution where professional guidance focuses on spiritual development and purpose-driven learning. Through qualitative interviews with career advisors across various disciplines, the research explores how advisors define student success, integrate faith into their advising practices, and support students in aligning their career aspirations with personal meaning and the university's religious mission. Grounded in the belief that holistic education fosters lifelong success, BYU emphasizes the development of the "total person," including moral and spiritual dimensions. Findings reveal that student success is not solely measured by employment outcomes …
Genetic Overlap Between Functional Impairment And Depression And Anxiety Symptom Severity: Evidence From The Glad Study, Megan Skelton, Jessica Mundy, Abigail Ter Kuile, Brett Adey, Cherie Armour, Joshua Buckman, Jonathan Coleman, Molly Davies, Colette R. Hirsch, Matthew Hotopf, Ian Jones, Gursharan Kalsi, Georgina Krebs, Sang Hyuck Lee, Yuhao Lin, Andrew M. Mcintosh, Alicia J. Peel, Christopher Rayner, Katharine Rimes, Daniel J. Smith, Katherine N. Thompson, David Veale, James T.R. Walters, Christopher Hübel, Gerome Breen, Thalia C. Eley
Genetic Overlap Between Functional Impairment And Depression And Anxiety Symptom Severity: Evidence From The Glad Study, Megan Skelton, Jessica Mundy, Abigail Ter Kuile, Brett Adey, Cherie Armour, Joshua Buckman, Jonathan Coleman, Molly Davies, Colette R. Hirsch, Matthew Hotopf, Ian Jones, Gursharan Kalsi, Georgina Krebs, Sang Hyuck Lee, Yuhao Lin, Andrew M. Mcintosh, Alicia J. Peel, Christopher Rayner, Katharine Rimes, Daniel J. Smith, Katherine N. Thompson, David Veale, James T.R. Walters, Christopher Hübel, Gerome Breen, Thalia C. Eley
School of Psychology
BACKGROUND: Functional impairment in daily activities, such as work and socializing, is part of the diagnostic criteria for major depressive disorder and most anxiety disorders. Despite evidence that symptom severity and functional impairment are partially distinct, functional impairment is often overlooked. To assess whether functional impairment captures diagnostically relevant genetic liability beyond that of symptoms, we aimed to estimate the heritability of, and genetic correlations between, key measures of current depression symptoms, anxiety symptoms, and functional impairment.
METHODS: In 17,130 individuals with lifetime depression or anxiety from the Genetic Links to Anxiety and Depression (GLAD) Study, we analyzed total scores …
Nuak Kinases: Signaling Mechanisms And Therapeutic Applications, Nicole M. Cullen, Peter Rosston, Bakhtawar Tufail, Anne E. D'Armond, Ayushi Patel, Dara H. Khosravi, Bridgette M. Collins-Burow, Van T. Hoang, Elizabeth C. Martin, David H. Drewry, Matthew E. Burow, Suresh K. Alahari
Nuak Kinases: Signaling Mechanisms And Therapeutic Applications, Nicole M. Cullen, Peter Rosston, Bakhtawar Tufail, Anne E. D'Armond, Ayushi Patel, Dara H. Khosravi, Bridgette M. Collins-Burow, Van T. Hoang, Elizabeth C. Martin, David H. Drewry, Matthew E. Burow, Suresh K. Alahari
School of Medicine Faculty Publications
The novel (nua) kinases 1 and 2 are two of 12 AMP-activated protein–related kinases whose signaling pathways are involved in cancer progression, as well as neurologic, fibrotic, and inflammatory diseases. Currently, there are 80 Food and Drug Administration-approved kinase inhibitors which target roughly 24 of the 500+ known human kinases, leaving most kinases underexplored, including NUAK1 and NUAK2. Thus, there is a critical need for selective inhibition of NUAK1 and NUAK2 signaling. Here, we review the protein structure, known upstream regulators and downstream targets, and expression profiles of NUAK1 and NUAK2 in cancerous compared to noncancerous tissue. We also delineate …
“I Laughed Along For Years But Hated It Inside:” Understanding Nuance In Peer Teasing Experiences Using A Thematic Analysis, Naomi C.Z. Andrews, Molly Dawes Ph.D.
“I Laughed Along For Years But Hated It Inside:” Understanding Nuance In Peer Teasing Experiences Using A Thematic Analysis, Naomi C.Z. Andrews, Molly Dawes Ph.D.
Faculty Publications
Introduction
Peer teasing is ubiquitous, yet ambiguous in nature. Despite recent attempts to delineate and clarify differences in teasing experienced as playful versus harmful, there remains overlap and complexity in these interactions. In the current study, we present a conceptual model of teasing, which includes many nested features that dynamically interact within a teasing episode. Using this conceptual model to guide our work, the goal of the current study was to use qualitative inquiry to bring further conceptual clarity to the overlap between teasing that is experienced as playful versus harmful.
Method
Using semi-structured interviews, we asked university students ( …
Cone Vs. Vmat Srs Planning For Dual Targets: Effects Of Target Size, Separation, And Isocenter Displacement, Hannah Angeli
Cone Vs. Vmat Srs Planning For Dual Targets: Effects Of Target Size, Separation, And Isocenter Displacement, Hannah Angeli
Masters Projects
Objective: This study compares cone-based and volumetric modulated arc therapy (VMAT) stereotactic radiosurgery (SRS) planning for dual intracranial targets, examining the effects of target size, inter-target separation, and isocenter displacement on dosimetric outcomes. Methods: Plans were generated for spherical targets of 8.0 mm, 10.0 mm, and 12.0 mm diameters using both VMAT and cone-based techniques with single-isocenter configurations. Key metrics including maximum dose, volumes of normal brain receiving 12 Gy and 50% of the prescription dose (V12Gy, V50%), high-dose volume (V100%), gradient index, and target coverage were evaluated. Results: Cone-based plans demonstrated superior dose conformity and reduced normal tissue exposure …
Increased Fungal Burden In The Gastrointestinal Tract Of Brain-Dead Organ Donors, Erika J Nachman, Colleen K Ardis, A Kyle B Ardis, Javier Nieto, Madeline M Bresson, Clare M Robertson, Maggie N Seale, Nora M Villafuerte, Zhe Lyu, Eva C Preisner, Heather A Danhof, Sara C Di Rienzi, Yolanda T Becker, Robert A Britton
Increased Fungal Burden In The Gastrointestinal Tract Of Brain-Dead Organ Donors, Erika J Nachman, Colleen K Ardis, A Kyle B Ardis, Javier Nieto, Madeline M Bresson, Clare M Robertson, Maggie N Seale, Nora M Villafuerte, Zhe Lyu, Eva C Preisner, Heather A Danhof, Sara C Di Rienzi, Yolanda T Becker, Robert A Britton
Faculty, Staff and Students Publications
Approximately 3% of organ transplant recipients will be diagnosed with an invasive fungal infection (IFI), with 10%-47% being fatal. The source of IFI is typically not known, but Candida spp. cause the majority of IFI cases. We obtained intestines from two types of organ donors, brain-dead (BD) (n = 7) and donation after circulatory death (DCD) (n = 5), to sample microbes from the mucosal surface and the lumen. BD donors were parenterally fed and treated with corticosteroids in the days before procurement, whereas DCD donors were enterally fed and not given corticosteroids. We found fungi present in …
Real-Time Experiences Of Racism And Stress In Association With Postpartum Weight Retention: A Longitudinal Ecological Momentary Assessment Study, Dara M Méndez, Amanda L Tapia, Sarah A Sanders, Andrea D Casas, Marquita Smalls, Esa M Davis, Stephen L Rathbun, Tiffany L Gary-Webb, Lora E Burke, Serwaa S Omowale, Linda A Adodoadji, John J Gianakas, Y Lai, Maisa Feghali, Meredith L Wallace
Real-Time Experiences Of Racism And Stress In Association With Postpartum Weight Retention: A Longitudinal Ecological Momentary Assessment Study, Dara M Méndez, Amanda L Tapia, Sarah A Sanders, Andrea D Casas, Marquita Smalls, Esa M Davis, Stephen L Rathbun, Tiffany L Gary-Webb, Lora E Burke, Serwaa S Omowale, Linda A Adodoadji, John J Gianakas, Y Lai, Maisa Feghali, Meredith L Wallace
Faculty, Staff and Student Publications
Racial inequities in postpartum weight have been documented with limited studies on the influences of racism and other forms of discrimination. In a prospective longitudinal study applying ecological momentary assessment (EMA) and ambulatory assessment of weight, we measured the association between discrimination, stress, and postpartum weight change. The Postpartum Mothers Mobile Study is a cohort of 313 pregnant and birthing individuals who were followed during their second and third trimesters through 1 year postpartum. They were recruited in clinical settings between 2017 and 2020 in a major city center in Pennsylvania. Measures of racism and gender-based discrimination were collected via …