Digital Commons Network^™

Helping Families Learn About Social Emotional Learning, Madalyn Ross

Masters Projects

Having developmentally appropriate social-emotional skills is an essential component of a growing child, yet many children lack the social-emotional skills necessary to be successful in the classroom. Families play an important role in the development of a child, but research shows that there are significant gaps in the knowledge and use of social-emotional learning (SEL) that families have. This project explores the importance of family involvement and knowledge surrounding SEL by looking at certain aspects that hinder SEL growth, such as trauma and excessive screen time, and aspects that help children excel in SEL development, such as teacher education and …

Crafting Research That Resonates, Vishnu S. Pendyala

Open Educational Resources

A short presentation made to the students of SJSU’s Gateway PhD Program with Manchester Metropolitan University on August 5, 2025, at their annual research workshop. It serves as some general advice and inspiration to aspiring doctoral students.

More about the program here: https://ischool.sjsu.edu/gateway-phd-library-and-information-management

Information Theory Optimization Of Signals From Small-Angle Scattering Measurements, Robert P Rambo, John A Tainer

Faculty, Staff and Student Publications

Small-angle X-ray scattering (SAXS) of particles in solution informs on the conformational states and assemblies of biological macromolecules (bioSAXS) outside of cryo- and solid-state conditions. In bioSAXS, the SAXS measurement under dilute conditions is resolution limited, and through an inverse Fourier transform, the measured SAXS intensities directly relate to the physical space occupied by the particles via the P(r)-distribution. Yet, this inverse transform of SAXS data has been historically cast as an ill-posed, ill-conditioned problem requiring an indirect approach. Here, we show that through the applications of matrix and information theories, the inverse transform of SAXS intensity data is a …

Phase 2 Study Of Zilovertamab Vedotin In Participants With Metastatic Solid Tumors, Funda Meric-Bernstam, Martin Gutierrez, Enrique Sanz-Garcia, Diego Villa, Jun Zhang, Jennifer Friedmann, Fengting Yan, Mark A Socinski, John Sarantopoulos, Luis E Raez, Quincy S Chu, Maxime Chénard-Poirier, Manash Chatterjee, Hong Ren, Qi Liu, Douglas A Levine, Komal L Jhaveri

Faculty, Staff and Student Publications

Purpose: Zilovertamab vedotin, an antibody‒drug conjugate targeting receptor tyrosine kinase‒like orphan receptor 1 (ROR1), had manageable safety and promising antitumor activity in participants with relapsed or refractory non-Hodgkin lymphomas. We evaluated zilovertamab vedotin in participants with previously-treated metastatic solid tumors.

Methods: This phase 2, open-label, nonrandomized study (NCT04504916) enrolled participants with metastatic triple-negative breast cancer, hormone receptor‒positive (HR+) breast cancer, nonsquamous non‒small-cell lung cancer, platinum-resistant ovarian cancer, or pancreatic cancer. Participants received zilovertamab vedotin ≤2.5 mg/kg once every 3 weeks (Q1/3W) or < 1.75 mg/kg twice every 3 weeks (Q2/3W). Primary endpoint was objective response rate (ORR) per RECIST v1.1 by blinded independent central review. ROR1 protein expression was correlated with clinical outcomes.

Results: 102 participants were enrolled (Q1/3W, n=70; Q2/3W, n=32). ORR was 1% (95% CI, 0%‒8%) with …

The Neurosurgeon's Role In The Brain Economy: How Strategic Investment In Neurosurgical Care And Innovation Will Improve Global Outcomes, Daniela A Perez-Chadid, Riya M Dange, Harris A Eyre, Graham Fieggen, Kerry A Vaughan, Sameer A Sheth, Jafri Malin Abdullah, Bello B Shehu, Daniel Donoho, Samuel Browd, Agustin Ibanez, Saksham Gupta, Frederick Lang, Anil Nanda, Gail Rosseau

Faculty, Staff and Student Publications

No abstract provided.

Interactive 3d Segmentation For Primary Gross Tumor Volume In Oropharyngeal Cancer, Mikko Saukkoriipi, Jaakko Sahlsten, Joel Jaskari, Lotta Orsmaa, Jari Kangas, Nastaran Rasouli, Roope Raisamo, Jussi Hirvonen, Helena Mehtonen, Jorma Järnstedt, Antti Mäkitie, Mohamed Naser, Clifton Fuller, Benjamin Kann, Kimmo Kaski

Faculty, Staff and Student Publications

Radiotherapy is the main treatment modality of oropharyngeal cancer (OPC), in which an accurate segmentation of primary gross tumor volume (GTVt) is essential but also challenging due to significant interobserver variability and the time consumed in manual tumor delineation. For such a challenge an interactive deep learning (DL) based approach offers the advantage of automatic high-performance segmentation with the flexibility for user correction when necessary. In this study, we investigate an interactive DL for GTVt segmentation in OPC by introducing a novel two-stage Interactive Click Refinement (2S-ICR) framework and implementing state-of-the-art algorithms. Using the 2021 HEad and neCK TumOR dataset …

Association Between Allostatic Load And Accelerated White Matter Brain Aging: Findings From The Uk Biobank, Li Feng, Zhenyao Ye, Zewen Du, Yezhi Pan, Travis Canida, Hongjie Ke, Song Liu, Shuo Chen, L Elliot Hong, Peter Kochunov, Jie Chen, David K Y Lei, Edmond Shenassa, Tianzhou Ma

Faculty, Staff and Student Publications

White matter (WM) brain age, a neuroimaging-derived biomarker indicating WM microstructural changes, helps predict dementia and neurodegenerative disorder risks. The cumulative effect of chronic stress on WM brain aging remains unknown. In this study, we assessed cumulative stress using a multi-system composite allostatic load (AL) index based on inflammatory, anthropometric, respiratory, lipidemia, and glucose metabolism measures, and investigated its association with WM brain age gap (BAG), computed from diffusion tensor imaging data using a machine learning model, among 22 951 European ancestries aged 40 to 69 (51.40% women) from UK Biobank. Linear regression, Mendelian randomization, along with inverse probability weighting, …

Metabolic Dysfunction-Associated Steatotic Liver Disease In People With Type 1 Diabetes., Brynlee Vermillion, Yuanjie Mao

Ambulatory and Primary Care Articles

Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized as a significant comorbidity in individuals with type 1 diabetes (T1D), despite its historical association with type 2 diabetes. This review focuses on summarizing current findings regarding the role of insulin resistance in the development of MASLD in T1D, as well as examining the relationship between MASLD and diabetes-related complications. We will also briefly discuss the prevalence, diagnostic challenges, associated complications, and potential mechanisms underlying MASLD in T1D. Although insulin resistance is well established in MASLD among those with type 2 diabetes, its role in T1D requires further clarification. Emerging markers, …

Socioeconomic Determinants Of Depression And Anxiety Disorders In Puerto Ricans Living On The Island And The Mainland, Herman Alvarado

Walden Dissertations and Doctoral Studies

Research shows that, among Hispanics, depression and anxiety disorders are the two most prevalent mental disorders, particularly for Puerto Ricans. The socioecological model approaches mental health conditions from a perspective where multiple levels in society influence health-related behaviors. Based on this approach, this quantitative study looked at how socioeconomic factors - marital status, education, employment, and residential status were related to a diagnosis of depression or anxiety in Puerto Ricans. This study also explored whether there were differences between two groups of Puerto Ricans: those living on the island compared to those living in the 50 states. Analysis was conducted …

Perceptions Of Nonclinical Healthcare Executives On Advancing Physical Therapists Into Executive Healthcare Leadership Positions, Lindsey Johnston

Walden Dissertations and Doctoral Studies

Healthcare professionals often aspire to transition beyond clinical roles into organizational leadership. In particular, physical therapists may seek executive leadership opportunities beyond rehabilitation departments. However, there is limited understanding of how nonclinical healthcare executives perceive physical therapists advancing into these roles. This qualitative study aimed to understand nonclinical healthcare executives' perceptions regarding physical therapists’ advancement to executive healthcare leadership positions. The study was guided by new institutional theory and Level 5 leadership theory and addressed four research questions to explore these perceptions in depth. A general qualitative methodology was employed, with data collected through semistructured, virtual interviews with eight nonclinical …

Rare Variants In Bmal1 Are Associated With A Neurodevelopmental Syndrome, Vishnu Anand Cuddapah, Dechun Chen, Bumsik Cho, Rebecca Moore, Mohnish Suri, Hana Safraou, Frederic Tran-Mau-Them, Ashley Wilson, Jacqueline Odgis, Atteeq U Rehman, Carol Saunders, Shiva Ganesan, Vaidehi Jobanputra, Stephen W Scherer, Ingo Helbig, Amita Sehgal

Duncan NRI Faculty and Staff Publications

Children with neurodevelopmental disorders exhibit highly penetrant sleep and circadian dysfunction, but the underlying mechanisms are unclear. We asked whether a subset of individuals with neurodevelopmental disorders might have genetic variants in genes known to drive circadian rhythms. Through international collaboration, we identified ten individuals with very rare genetic variants in BMAL1, a core component of the molecular clock. These individuals exhibited overlapping signs and symptoms including developmental delay, autism spectrum disorder, and variably penetrant marfanoid features. We functionally tested the identified BMAL1 variants in cell culture and in vivo and found disrupted BMAL1 function. These findings demonstrate that …

Real-Time Temperature Estimation Of The Machine Drive Sic Modules Consisting Of Parallel Chips Per Switch For Reliability Modelling And Lifetime Prediction, Tamer Kamel, Olamide Olagunju, Temitope Johnson

School of Engineering, Computing and Mathematics

This paper presents a new methodical procedure to monitor in real time the junction temperature of SiC Power MOSFET modules of parallel-connected chips utilized in machine drive systems to develop their reliability modelling and predict their lifetime. The paper implements the on-line measurements of temperature-sensitive electrical parameters (TSEP) approach, particularly the quasi-threshold voltage and the on-state drain to source voltage, to estimate the junction temperature in real time. The proposed procedure firstly applied computational fluid dynamics analysis on the module under study to determine the chip which undergoes the maximum junction temperature during typical operation of the module. Then, a …

Rapid And Sustainable Deep Testosterone Reduction Predicts Effective Androgen Deprivation Therapy For Metastatic Hormone-Sensitive Prostate Cancer., Ze Wang, Haiyang Xiao, Chongliang Zheng, Jian Chen, Qiming Chen, Zhenzhen Chen, Dianzheng Zhang, Luofu Wang, Weihua Lan, Qiuli Liu, Jun Jiang

PCOM Scholarly Works

The testosterone (TT)/androgen receptor axis plays a crucial role in the initiation and progression of prostate cancer (PCa). We aimed to investigate the predictive value of serum TT levels on metastatic PCa progression. A total of 219 patients with metastatic PCa were included in this study. Analyses performed included Pearson's correlation test, Wilcoxon rank test, Chi-square test, Cox regression, and Kaplan-Meier analysis. High serum TT levels (> 405 ng/dL) before ADT treatment, deep testosterone reduction (DTR) within the first year of ADT, rapid DTR within 3 months of ADT, and sustained DTR in the first year of ADT are associated …

Development And Validation Of Venous Thromboembolism-Bidirectional Encoder Representations From Transformers (Vte-Bert) Natural Language Processing Model, Omid Jafari, Shengling Ma, Barbara D Lam, Jun Y Jiang, Emily Zhou, Mrinal Ranjan, Justine Ryu, Raka Bandyo, Arash Maghsoudi, Bo Peng, Christopher I Amos, Abiodun Oluyomi, Nathanael R Fillmore, Jennifer La, Ang Li

Faculty, Staff and Students Publications

Background: Accurate and rapid phenotyping of venous thromboembolism (VTE) in longitudinal studies is important. A natural language processing (NLP) tool externally validated in representative patients is lacking.

Objectives: To train and validate an efficient NLP model to detect incident VTE event.

Methods: We designed a novel NLP platform, NLPMed, to assist thrombosis researchers with data preprocessing, phenotype annotation, language model finetuning, and NLP application. Using clinical notes, discharge summaries, and radiology reports from patients with cancer at 2 healthcare institutions, we finetuned Bio_Clinical Bidirectional Encoder Representations from Transformers (BERT) to develop VTE-BERT. The new model was trained to detect acute …

Three Things We Can Do Now To Reduce The Risk Of Avian Influenza Spillovers, Kenneth B Yeh, William P Bahnfleth, Elaine Bradford, Carol Cardona, Kristen K Coleman, Peter J Hudson, Bernadeta Dadonaite, Rebecca J Hutchins, Anthony Maresso, C Raina Macintyre, Matthew Scotch

Faculty, Staff and Students Publications

No abstract provided.

Survival To Hospital Discharge In The Fetus With Moderate To Severe Mitral Regurgitation Either In Isolation Or In Combination With Aortic Valve Stenosis Or Atresia, A Fetal Heart Society Collaborative Study, Betul Yilmaz Furtun, Kavitha Pundi, Anita Moon-Grady, Nicole Cresalia, Asela Nieuwsma, Sarah K Gelehrter, Bhawna Arya, Mary T Donofrio, Christopher Statile, Ann Kavanaugh-Mchugh, Lindsay Freud, Elijah Bolin, Megan Warner, Sowmya Balasubramanian, James Strainic, Carol Wittlieb-Weber, Nelangi M Pinto, Lisa Hornberger, Shaine A Morris

Faculty, Staff and Students Publications

Background: Case series report high mortality after fetal diagnosis of moderate to severe mitral regurgitation in combination with left atrial dilation, hydrops, or restrictive atrial septum. However, overall outcomes and specific high-risk features remain unclear.

Methods: We performed a multicenter retrospective cohort study of fetuses with ≥moderate mitral regurgitation and normal cardiac connections evaluated January 1, 2005 to January 31, 2016. Fetuses undergoing fetal cardiac intervention (FCI) were described separately. We assessed associations between fetal echocardiographic features and discharge mortality using mixed logistic regression and classification and regression tree modeling, stratified by studies performed < 28 and ≥28 weeks gestational age (GA).

Results: Of 67 fetuses, 96% had …

Leishmania In Texas: A Contemporary One Health Scoping Review Of Vectors, Reservoirs, And Human Health, Morgan H Jibowu, Richard Chung, Nina L Tang, Sarah Guo, Leigh-Anne Lawton, Brendan J Sullivan, Dawn M Wetzel, Sarah M Gunter

Faculty, Staff and Students Publications

Leishmaniasis, a vector-borne neglected tropical disease, affects over 6.2 million people globally. Case acquisition is increasingly recognized in the United States, and in Texas, most reported cases are locally acquired and speciated to Leishmania mexicana. We conducted a scoping literature review to systematically assess contemporary research on Leishmania in humans, animals, reservoir hosts, or vectors in Texas after 2000. Out of 22 eligible studies, the most prevalent themes were case reports, followed by studies on domestic animals, reservoirs, and vectors, with several studies bridging multiple disciplines. Climate change, urbanization, and habitat encroachment appear to be driving the northward expansion …

Rescue Of Male Infertility By Human Prss55 In Transgenic Mice Establishes A Contraceptive Research Model, Courtney M Sutton, Kohei Umezu, Daisuke Mashiko, Masahito Ikawa, Irina V Larina, Thomas X Garcia, Martin M Matzuk

Faculty, Staff and Students Publications

The development of non-hormonal male contraceptives requires validated preclinical models. This study investigated whether human orthologs of two mouse testis-specific serine proteases, PRSS55 and TMPRSS12, both essential for male fertility in mice, could functionally rescue the infertility phenotypes of their respective knockout mouse lines. We generated transgenic mouse lines expressing human PRSS55 with either an extracellularly or intracellularly positioned C-terminal 3xFLAG tag (RES GPI or RES TM), and a line expressing human TMPRSS12 with a C-terminal 3xFLAG tag (T12 RES), all on their respective mouse null backgrounds. Fertility was assessed through continuous mating trials, and sperm parameters were evaluated. Both …

Grade Concept Paper 9: Rationale And Process For Creating A Grade Ontology, Paul Whaley, Brian Alper, Joanne Dehnbostel, Carlos Alva-Diaz, Stavros Antoniou, Antonio Bognanni, Javier Bracchiglione, Therese Kristine Dalsbø, Sean Grant, Jennifer Hunter, Alfonso Iorio, Malgorzata Lagisz, Harold Lehmann, Sheyu Li, Joerg Meerpohl, Saphia Mokrane, Cauê Monaco, Ignacio Neumann, Kevin Pottie, Shahab Sayfi, Nigar Sekercioglu, Jasvinder Singh, Bernardo Sousa-Pinto, Janice Tufte, Lenny Thinagaran Vasanthan, Li Wang, Jun Xia, Xiaomei Yao, Holger Schünemann

Faculty, Staff and Students Publications

Context: As the rate of research production accelerates, the ability to efficiently and unambiguously communicate judgments relating to the synthesis, evaluation, and use of scientific information becomes paramount.

Perspective: Scientific information can be viewed as a "layered infrastructure" of data, evidence, knowledge, and use. The GRADE approach serves as a de facto data standard for this infrastructure, supporting movement between layers by reducing ambiguity in claims to knowledge (in the form of judgements of certainty in the evidence when answering research questions) and level of commitment to possible solutions to problems (in the form of strength of recommendations for interventions). …

A Rapid, Simple, And Economical Method For The Isolation Of Ribosomes And Translational Machinery For Structural And Functional Studies, Jessey Erath, Danielle Kemper, Elisha Mugo, Alex Jacoby, Elizabeth Valenzuela, Courtney F Jungers, Wandy L Beatty, Yaser Hashem, Marko Jovanovic, Sergej Djuranovic, Slavica Pavlovic Djuranovic

2020-Current year OA Pubs

Ribosomes are RNA-protein complexes essential for protein synthesis and quality control. Traditional methods for ribosome isolation are labor-intensive, expensive, and require a substantial amount of biological material. In contrast, our method, RNA affinity purification using poly-lysine (RAPPL), provides a rapid, simple, and cost-effective alternative applicable to various species and types of starting material (cell lysates, whole cells, organs, or whole organisms). It is also compatible with traditional isolation techniques. Here, we describe the use of RAPPL for rapid isolation, functional screening, and structural analysis of ribosomes and associated factors. We also demonstrate the application of RAPPL in investigating ribosome-associated resistance …

Three Positively Charged Binding Sites On The Eastern Equine Encephalitis Virus E2 Glycoprotein Coordinate Heparan Sulfate- And Protein Receptor-Dependent Infection, Maria D H Alcorn, Chengqun Sun, Theron C Gilliland Jr, Tetyana Lukash, Christine M Crasto, Saravanan Raju, Michael S Diamond, Scott C Weaver, William B Klimstra

2020-Current year OA Pubs

Naturally circulating strains of eastern equine encephalitis virus (EEEV) bind heparan sulfate (HS) receptors and this interaction has been linked to neurovirulence. Previous studies associated EEEV-HS interactions with three positively charged amino acid clusters on the E2 glycoprotein. One of these sites has recently been reported to be critical for binding EEEV to the very-low-density lipoprotein receptor (VLDLR), an EEEV receptor protein. The proteins apolipoprotein E receptor 2 (ApoER2) isoforms 1 and 2, and LDLR have also been shown to function as EEEV receptors. Herein, we investigate the individual contribution of each HS interaction site to EEEV HS- and protein …

Conservative Oxygen Therapy In Mechanically Ventilated Critically Ill Adult Patients: The Uk-Rox Randomized Clinical Trial, Uk-Rox Investigators, Daniel S Martin, Doug W Gould, Tasnin Shahid, James C Doidge, Alex Cowden, Zia Sadique, Julie Camsooksai, Walton N Charles, Miriam Davey, Amelia Francis-Johnson, Roger M Garrett, Michael P W Grocott, Joanne Jones, Lamprini Lampro, Diane M Mackle, B Ronan O'Driscoll, Alvin Richards-Belle, Anthony J Rostron, Tamás Szakmány, Alex Warren, Paul J Young, Kathryn M Rowan, David A Harrison, Paul R Mouncey

Peninsula Medical School

IMPORTANCE: Supplemental oxygen is frequently given to patients in intensive care units (ICUs); however, there is insufficient evidence to guide its therapeutic use and to minimize the potential harm caused by administering too little or too much.

OBJECTIVE: To determine whether reducing exposure to supplemental oxygen through a strategy of conservative oxygen therapy by using a peripheral oxygen saturation (Spo2) target of 90% (range, 88%-92%) reduces mortality at 90 days in mechanically ventilated adult patients receiving supplemental oxygen in the ICU.

DESIGN, SETTING, AND PARTICIPANTS: Multicenter, pragmatic, randomized clinical trial conducted in 97 ICUs in the UK including 16 500 …

Examining The Factor Structure And Correlates Of The Flourishing-At-Work Scale In United States School Psychologists, Nikita Pike

Electronic Theses and Dissertations Archive

Despite moderate levels of stress and burnout in their work, school psychologists in the United States tend to be satisfied with their jobs. Although researchers have addressed why school psychologists view their work as important, there is yet another important feature of the workplace that has not been examined in this population: flourishing at work. This study aimed to enhance the understanding of flourishing at work in school psychologists by examining an existing scale, the Flourishing-at-Work Scale, completed online by a national sample of United States school psychologists. Data from a sample of 369 practicing school psychologists were used in …

Examining The Active Ingredients In An Anti-Stigma Intervention For Individuals With A Criminal History, Kaylee Cook

Electronic Theses and Dissertations Archive

Obtaining employment is key to successful reintegration for people who have been incarcerated. However, employers are often hesitant to hire formerly incarcerated persons due to general negative attitudes toward them and concern that they will not exhibit positive work behaviors. Interventions to reduce general types of stigma exist, with primary strategies involving education and/or contact. Most research examining the effectiveness of stigma-reducing strategies largely focus on reducing identity-based stigma (e.g., race, mental illness), with limited research on reducing choice-based stigma, such as those with criminal histories. However, regardless of targeted stigma, there is no consensus regarding which intervention format (i.e., …

A Critical Seat At The Table: A Qualitative Examination Of Resiliency And Retention Among Black School Psychologists, Jasric Bland

Electronic Theses and Dissertations Archive

As discussions on systemic racism, diversity, equity, and inclusion in education increase, advocacy for Black students is essential, as their voices are often undervalued (Anderson & Graham, 2015). School psychologists play a crucial role in decisions that affect students’ academic, social, and emotional well-being, yet the challenge of increasing Black representation in the field persists (Goforth et al., 2021; Grapin et al., 2016; Proctor et al., 2017), making advocacy and representation a challenge. This raises an important question about retaining Black practitioners within school psychology, however, research on the resiliency and retention of Black school psychologists remains limited. Further studies …

Predictors Of Sanction Length Following Correctional Disciplinary Hearings: The Role Of Individual Characteristics, Misconduct Type, And Placement In Segregation, Jade Renee Horton

Electronic Theses and Dissertations Archive

Misconduct by incarcerated individuals is a significant threat to institutional safety. While research has highlighted discrepancies in who engages or who is reported as engaging in misconduct and suggests staff biases may impact disciplinary decisions, available research tends to narrowly focus on the use of disciplinary segregation as an outcome and often neglects other potential disciplinary outcomes that are less serious and the predictors of those outcomes. The current study examined predictors of the seriousness of outcomes, measured in length (weeks) of imposed sanction, of disciplinary hearings. It was hypothesized that those who are identified as Black, with a serious …

Gender And Sexuality In Homeschooling: An Analysis Of Gender Constructs And Sexual Behaviors Within Homeschooling Communities, Hannah Grace Badley

Electronic Theses and Dissertations Archive

Homeschooling has grown increasingly popular as a form of alternative education both in the United States and globally. However, research examining the public health implications of this homeschooling is minimal, especially research focusing on sexual behaviors and gender identity development. Similarly, research on homeschooling tends to focus on the caregivers' or parents' perceptions or motivations to homeschool, as opposed to centering the experiences and voices of those who are or were homeschooled. Because of this, very little is known about the ways homeschooled youth experience sexual health education, how gender identity development occurs, and how homeschoolers access reproductive healthcare. To …

Matters Of The Heart And Mind: Cardiovascular And Psychosocial Risk Factors For Cognitive Impairment And Dementia Among Older Adults In The Us, Markquest Jarius Ajoku

Electronic Theses and Dissertations Archive

Cognitive function decline has been associated with cardiovascular and psychosocial factors. The resulting cognitive impairment and dementia (CID), including Alzheimer’s disease and other related dementia, impose a significant burden among older adults (aged 65 or older), which is expected to increase by 55% or more. CID affected 20% of older adults in the US, and the risk of CID doubles every five years after age 65. This study examined the impact of heart diseases or stroke, depressive symptoms in middle-age, and loneliness on the risk of CID among older adults in the US. We conducted a longitudinal study using the …

Integrating The Simplified Silhouette Score Into The Vector In Partition (Vip) Algorithm For Cluster Validation, Luke Xavier Pirrotta

Electronic Theses and Dissertations Archive

Clustering analysis is a fundamental technique in machine learning, with K-means and its variants being widely used for their interpretability and efficiency. The Vector in Partition (VIP) algorithm extends K-means by incorporating a multi-dimensional distance measure for nested genetic data structures. Still, it inherits the challenge of selecting the optimal number of clusters (k). This thesis proposes integrating the simplified silhouette score (SSI) into VIP’s optimization options to improve k selection. Through simulation studies comparing SSI with currently implemented methods (Elbow, Slope, and Minimum AIC and BIC), we demonstrate that SSI consistently performs on par or better than existing methods, …

A School Nursing A Delight For Design

University press releases and calendars

No abstract provided.