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The Free Press Vol. 57, Issue 2, 09-08-2025, Julz Levesque, Caraline Squires

Free Press, The

ESPORTS Arena Opening--Will Susan Collins Lose?--MovieTalk and Events--World Cup in America--Letters from the Editors

Synthesis, Pharmacokinetic Studies, And Metabolite Analysis Of Meridianin C In Rats Using A Validated Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry Method, Liangyu Xu, Zhaogen Wu, Karna Ramachandraiah, Guihun Jiang, Guozhe Zhang

School of Graduate Studies Faculty Publications

Introduction: Meridianin C (MC) is a marine-derived indole alkaloid that has demonstrated kinase inhibitory and anti-tumor activities. Despite its diverse biological properties, no previous reports have systematically evaluated the in vivo quantitative analysis of MC and its metabolites. Methods: In this study, MC was synthesized following a previously reported procedure with slight modifications. A sensitive, accurate, and reliable ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC–MS/MS) method was developed to simultaneously detect MC and its five major metabolites (MC-1-N-O-GluA, MC-1-N-O-SO3H, MC-2′-N-O-GluA, MC-2′-N-O-SO3H, and MC-O-GluA-didehydration) in rat plasma. Rats received a single oral dose of MC (100 mg/kg), and pharmacokinetic analysis was …

Postoperative Fluid Restriction To Prevent Delayed Hyponatremia After Endoscopic Transsphenoidal Surgery, Doriann Klaassen, Shinghei Mok, Jenie Y Hwang, Kelley J Williams, Brendan M Fong, Ralph G Dacey, Nyssa F Farrell, Joshua W Osbun, Keith M Rich, Lauren T Roland, John S Schneider, Gregory J Zipfel, Chongliang Luo, Albert H Kim, Julie M Silverstein, Et Al.

2020-Current year OA Pubs

BACKGROUND: Readmission following endoscopic endonasal transsphenoidal surgery (EETS) for pituitary neuroendocrine tumor (PitNET) and other sellar pathology is most commonly due to delayed hyponatremia. Studies suggest postoperative fluid restriction (FR) reduces delayed hyponatremia. We present a prospective randomized controlled study evaluating post-EETS FR.

METHODS: 300 participants were scheduled for EETS (2016-2023) at a single institution. Patients with CKD, CHF, arginine vasopressin deficiency on postoperative day (POD) 3, chronic hyponatremia, and untreated adrenal insufficiency or hypothyroidism were excluded. Groups included control (ad-lib, n = 94), moderate FR (1.8 L/day or 2 L/day weight > 100 kg, n = 39), and strict FR …

September 8, 2025

The Gavel Gazette

No abstract provided.

Anthracycline-Induced Cardiomyopathy In Breast Cancer Patients In Oman: A Retrospective Study, Hussain A. Al-Lawati, Khalid Al Baimani, Mohammed N. Al Rawahi

Sultan Qaboos University Medical Journal

Objectives: Anthracyclines are widely used in the treatment of breast cancer. One of the known adverse effects of anthracyclines is anthracycline-induced cardiomyopathy. Studies done worldwide showed that the prevalence of chemotherapy-induced cardiomyopathy is approximately 9%. However, studies evaluating this complication prevalence, risk factors and cumulative dose are lacking in Oman. This study aimed to investigate the prevalence of anthracycline-induced cardiomyopathy among breast cancer patients in Oman. Methods: This retrospective study included all breast cancer patients who received anthracycline-based chemotherapy exclusively between September 2008 and December 2020 at Sultan Qaboos University Hospital in Muscat. Patients with partial treatment, coexisting …

Detecting Electrical Submersible Pump (Esp) Failures And Estimating Run Life Using Artificial Neural Networks, Mostafa Ahmed Sobhy

Theses and Dissertations

Electric Submersible Pumps (ESPs) are one of the important artificial lift methods for sustaining production in mature and high-water-cut wells; but may suffer frequent failures due to mechanical, electrical, hydraulic, chemical, and operational failures. These failures can yield substantial deferred production and intervention costs. Plenty of ESP installations are fitted with downhole sensors. Yet, it is observed that the current industry practice underutilizes the wealth of available sensor and operational data and lacks standardized, explainable failure-type identification and classification.

In this thesis, a comprehensive Machine Learning (ML) and Deep Learning (DL) framework was introduced for ESPs that simultaneously estimates remaining …

A Qualitative Study Of Cash Welfare Assistance Recipients’ Preparedness For Economic Self-Sufficiency, Kimberly Pickens

Walden Dissertations and Doctoral Studies

Single mothers receiving cash welfare assistance through the Temporary Assistance for Needy Families (TANF) program, may not be prepared for economic self-sufficiency due to TANF’s primary focus on employment and limited focus on self-sufficiency barriers. Past studies have found that cash welfare assistance recipients may not become self-sufficient due to low-wage employment, limited education, and the lack of a public policy-based standardization of the concept of economic self-sufficiency. The purpose of this study was to examine the experiences of single mother TANF recipients pursuing economic self-sufficiency through the lens of the capabilities approach, life chances theory, and the feminization of …

Coping Self-Efficacy, Acculturation, Gender, Socioeconomic Status, And Perceived Discrimination As Predictors Of Depression Among Nigerian Immigrants In The United States, Olatunde O. Osibote

Walden Dissertations and Doctoral Studies

Nigerian immigrants represent one of the fastest-growing immigrant populations in the United States. Relocating to a new country can be a major source of stress, often increasing individuals’ vulnerability to mental health challenges. While considerable research has examined predictors of depression in the general population and among certain immigrant groups, limited attention has been given to these factors in the context of Nigerian immigrants in the U.S. This study aimed to address that gap by applying Berry’s acculturation theory to investigate predictors of depression within this population. A quantitative, cross-sectional, correlational survey design was used to examine whether acculturation, socioeconomic …

Social Service Supervisors' Perceptions Of Professional Development Training, Jaida Elaine Patterson

Walden Dissertations and Doctoral Studies

Chafee Independent Living Skills and Goals Program (CILSGP) is a federally mandated program for public child welfare organizations that provide services to adolescents and young adults in the foster care system. The problem that was addressed through this study was that program administrators are unsure of the additional professional development (PD) needs of the social service supervisors at the study site, a foster care independent living program for youth. The purpose of this basic qualitative study was to investigate social service supervisors’ perceptions on the PD they receive; the influence the PD has on their self-concept as a learner, their …

Impacts Of Environmental Distractions And Interruptions On Unsupervised Digital Cognitive Assessments In Older Adults: Cognitive Ecological Momentary Assessment Study, Matthew Welhaf, Hannah Wilks, Andrew J Aschenbrenner, Samhita Katteri, John C Morris, Jason J Hassenstab

2020-Current year OA Pubs

BACKGROUND: Unsupervised cognitive assessments are becoming commonly used in studies of aging and neurodegenerative diseases. As assessments are completed in everyday environments and without a proctor, there are concerns about how common distractions may impact performance and whether these distractions may differentially impact those experiencing the earliest symptoms of dementia.

OBJECTIVE: We examined the impact of self-reported interruptions, testing location, and social context during testing on remote cognitive assessments in older adults.

METHODS: Participants from the Ambulatory Research in Cognition smartphone study were classified as cognitively normal (n=380) or as having very mild dementia (n=37). Participants completed daily tests of …

Tiny Particles, Big Stakes: The Strategic Implications Of Micro‑ And Nanoplastics, James Giordano, Ashok Vaseashta

Strategic Insights

This commentary explores how micro- and nanoplastics, tiny plastic fragments present throughout the environment, pose emerging strategic challenges beyond environmental and health concerns. While micro- and nanoplastics are now found in water, soil, plants, animals, and even human bodies, their long-term effects on ecosystems, food and water safety, and human health remain poorly understood. These particles can infiltrate critical systems, potentially affecting troop readiness, infrastructure resilience, and national food security. Nanoplastics may also serve as vectors for biological or chemical contaminants, complicating detection and mitigation. The article argues that micro- and nanoplastics should be treated as a strategic security issue, …

Impact Of Composite Materials Research On Underrepresented Communities, Neil Mahesh Bedagkar, Ramanan Sritharan, Wyatt Barnes

Mechanical Engineering

This research assesses how advancements in composites material research affect communities from lower socioeconomic backgrounds, using a dual track strategy to quantitatively and qualitatively examine their impact. A keyword-based classification algorithm was applied to a sample of research papers from ScienceDirect spanning the last 24 years to quantify which engineering industries benefit most from this research. The findings indicate that the construction industry benefits the most, followed by the automotive, defense, renewable energy, and biomedical sectors. A broader qualitative analysis of the social implications of these industries was also conducted to provide context. Each sector were found to have either …

Budget Recommendations Fy2026-2027, Tennessee. Commission On Children And Youth.

Annual Report

No abstract provided.

Sex-Specific Associations Between Early Life Unpredictability And Trajectories Of Body Mass Index From Infancy To Adolescence, Emily M. Melnick, Lilybelle K. Deer, Jenalee R. Doom, Hal S. Stern, Curt A. Sandman, Laura M. Glynn, Elysia P. Davis

Psychology Faculty Articles and Research

Objective:

Unpredictability in early life is an understudied aspect of early life adversity that provides important signals to the child about their environment. Recent work shows the predictability of patterns of parental signals on a moment-to-moment timescale sculpts the developing brain during sensitive windows, offering a potential pathway through which early life experiences shape child development. Both experimental non-human animal models and observational human research show sex-specific links between early life exposure to unpredictable patterns of parental sensory signals and aberrant offspring development. The impact of predictability of sensory signals on physical health outcomes, such as BMI, remains unknown. Here …

Staff Education To Implement The Phq-9 For Depression Screening, Lydia Emuobosa Opara

Walden Dissertations and Doctoral Studies

Depression is common yet frequently underdiagnosed in group home settings serving adult and geriatric residents. This Doctor of Nursing Practice (DNP) project aimed to improve staff knowledge and promote routine use of the Patient Health Questionnaire-9 (PHQ-9), a validated depression screening tool, through an evidence-based educational intervention. A practice gap was identified at the project site due to inconsistent use and documentation of the PHQ-9, primarily linked to staff knowledge deficits. The project explored whether educating staff on PHQ-9 administration, scoring, and documentation would lead to improved knowledge, as measured by pre- and post-intervention assessments. Guided by the ADDIE instructional …

First-Generation College Students' Perceptions Of Undergraduate Degree Completion, Melinda Dianna Howard

Walden Dissertations and Doctoral Studies

The problem explored in this study was the low graduation rate of first-generation college students at the university study site. Using Bandura’s self-efficacy theory, the purpose of this basic qualitative study was to explore first-generation college graduates’ beliefs about their educational experience as students upon entering a bachelor’s degree program, identify obstacles, and understand ways to master those obstacles to successfully graduate. Six first-generation college graduates from the study site were recruited from FIRST, an on-campus support organization, for semistructured interviews using purposeful sampling. Due to COVID and the closing of the university study site at the time of recruitment, …

The Rider (2025-09-08), Daniela Martinez Salazar

The Rider Archives

Vol. 11, No. 2

Cyclical Matters: Black Labor, Temporality, And The Incomplete Reconstructions Within African American Literature, Courtney Walton

Dissertations

This dissertation examines the role literature plays in understanding black life post-reconstruction and post-civil rights movement. Specifically, I explore the continuation of injustices and mistreatment for black workers, the role black labor plays during the first and second post-reconstructions, and how literature can be used in framing this discussion. The similarities between these periods help us to better understand the cycle of racist societal expectations and the challenges black workers face integrating into society, discriminatory mandates required of black workers, the unfair job market, and forced labor. These periods interact cyclically in that the second post-reconstruction models the first post-reconstruction. …

Give People Money: The Effect Of Perceived Inequality In Everyday Life And Previous Cash-Transfer Programs On Support For Universal Basic Income, David Thomas Igliozzi

Dissertations

Economic inequality is a global concern with many adverse consequences for people across class divides. These consequences vary in scope—from negative effects on individual’s physical, mental, and social health to large-scale economic shifts which result from climate change (Galbraith & Hale, 2008; Hiesh & Pugh, 1993; Kaplan et al., 1996; La Ferrara & Alesina, 2000; Solt, 2008; Vilhjalmsdottir et al., 2016; Wilkinson & Pickett, 2007). Policy solutions meant to address the negative effects of economic inequality include government redistribution of wealth. Universal Basic Income (UBI), a specific and actionable policy of government redistribution, is a promising method of economic inequality …

“The Wonderful Swiftness Of The Soul”: Mental Movement And Religious Ethics In Medieval English Literature, Abigail Palmisano

Dissertations

This dissertation analyzes conceptual metaphors of psychological motion and stability in medieval English religious literature. I trace how language itself structures cultural approaches to epistemology, spiritual knowing, and virtue. Chapter One examines Alfred’s translation of Neoplatonic metaphors of psychological movement in the OE translations of The Consolation of Philosophy and Augustine’s Soliloquies. I argue that the reconfiguration of these metaphors into images of stability reveals an epistemology centered on certainty. Chapter Two compares the omission of motive psychological metaphor in Cynewulf’s Juliana and Ælfric’s “St. Agatha and St. Lucy” in process of translation. While Cynewulf’s depiction of virtue through stability …

Defining Breast Epithelial Cell Types In The Single-Cell Era, G Kenneth Gray, Eric G Carlson, Tatyana Lev, Bailey Marshall, Austin D Reed, Alex P Sánchez-Covarrubias, Alecia-Jane Twigger, Aleix Puig-Barbe, Aatish Thennavan, Ayodele Omotoso, Lyndsay M Murrow, Deeptiman Chatterjee, Siyuan He, Sara Pensa, Brian Aevermann, Norbert K Tavares, Natalie Chen, Jason A Hilton, Kerrigan Blake, Yunlong Liu, Kiet Phong, Zev J Gartner, Devon A Lawson, Alexander Swarbrick, Camila O Dos Santos, Sophia H L George, Joan S Brugge, Mark A Labarge, Harikrishna Nakshatri, Nicholas Navin, Kai Kessenbrock, Walid T Khaled

Faculty, Staff and Student Publications

Single-cell studies on breast tissue have contributed to a change in our understanding of breast epithelial diversity that has, in turn, precipitated a lack of consensus on breast cell types. The confusion surrounding this issue highlights a possible challenge for advancing breast atlas efforts. In this perspective, we present our consensus on the identities, properties, and naming conventions for breast epithelial cell types and propose goals for future atlas endeavors. Our proposals and their underlying thought processes aim to catalyze the adoption of a shared model for this tissue and to serve as guidance for other investigators facing similar challenges.

Drills Or Distress? Understanding The Psychological Effects Of Active Shooter Drills On Adolescents, Jeff R Temple, Elizabeth Baumler, Christian Paige Owen, Leila Wood

Faculty, Staff and Student Publications

Background: We sought to better understand the impact of exposure to active shooter drills (ASDs) on students' perceived stress, including those with disabilities and prior experiences with trauma.

Methods: We used data from a longitudinal study of ethnically diverse students (n = 2,033; 53.5% female) originally recruited in 2018 and followed annually thereafter. In addition to self-reporting on their perceived stress with ASDs, participants responded to questions about adverse childhood experiences, anxiety, suicidal ideation, and disability.

Results: Female students and those with a disability, probable anxiety, and suicidal ideation were more likely to be anxious after an ASD.

Conclusion: While …

Author Correction: Functional Mechanisms Underlying Pleiotropic Risk Alleles At The 19p131 Breast-Ovarian Cancer Susceptibility Locus, Kate Lawrenson, Siddhartha Kar, Karen Mccue, Karoline Kuchenbaeker, Kyriaki Michailidou, Jonathan Tyrer, Jonathan Beesley, Susan J Ramus, Qiyuan Li, Melissa K Delgado, Janet M Lee, Kristiina Aittomäki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Banu K Arun, Brita Arver, Elisa V Bandera, Monica Barile, Rosa B Barkardottir, Daniel Barrowdale, Matthias W Beckmann, Javier Benitez, Andrew Berchuck, Maria Bisogna, Line Bjorge, Carl Blomqvist, William Blot, Natalia Bogdanova, Anders Bojesen, Stig E Bojesen, Manjeet K Bolla, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Fiona Bruinsma, Joan Brunet, Shaik Ahmad Buhari, Barbara Burwinkel, Ralf Butzow, Saundra S Buys, Qiuyin Cai, Trinidad Caldes, Ian Campbell, Rikki Cannioto, Jenny Chang-Claude, Jocelyne Chiquette, Ji-Yeob Choi, Kathleen B M Claes, Linda S Cook, Angela Cox, Daniel W Cramer, Simon S Cross, Cezary Cybulski, Kamila Czene, Mary B Daly, Francesca Damiola, Agnieszka Dansonka-Mieszkowska, Hatef Darabi, Joe Dennis, Peter Devilee, Orland Diez, Jennifer A Doherty, Susan M Domchek, Cecilia M Dorfling, Thilo Dörk, Martine Dumont, Hans Ehrencrona, Bent Ejlertsen, Steve Ellis, Christoph Engel, Eunjung Lee, D Gareth Evans, Peter A Fasching, Lidia Feliubadalo, Jonine Figueroa, Dieter Flesch-Janys, Olivia Fletcher, Henrik Flyger, Lenka Foretova, Florentia Fostira, William D Foulkes, Brooke L Fridley, Eitan Friedman, Debra Frost, Gaetana Gambino, Patricia A Ganz, Judy Garber, Montserrat García-Closas, Aleksandra Gentry-Maharaj, Maya Ghoussaini, Graham G Giles, Rosalind Glasspool, Andrew K Godwin, Mark S Goldberg, David E Goldgar, Anna González-Neira, Ellen L Goode, Marc T Goodman, Mark H Greene, Jacek Gronwald, Pascal Guénel, Christopher A Haiman, Per Hall, Emily Hallberg, Ute Hamann, Thomas V O Hansen, Patricia A Harrington, Mikael Hartman, Norhashimah Hassan, Sue Healey, Florian Heitz, Josef Herzog, Estrid Høgdall, Claus K Høgdall, Frans B L Hogervorst, Antoinette Hollestelle, John L Hopper, Peter J Hulick, Tomasz Huzarski, Evgeny N Imyanitov, Kconfab Investigators, Australian Ovarian Cancer Study Group, Claudine Isaacs, Hidemi Ito, Anna Jakubowska, Ramunas Janavicius, Allan Jensen, Esther M John, Nichola Johnson, Maria Kabisch, Daehee Kang, Miroslav Kapuscinski, Beth Y Karlan, Sofia Khan, Lambertus A Kiemeney, Susanne Kruger Kjaer, Julia A Knight, Irene Konstantopoulou, Veli-Matti Kosma, Vessela Kristensen, Jolanta Kupryjanczyk, Ava Kwong, Miguel De La Hoya, Yael Laitman, Diether Lambrechts, Nhu Le, Kim De Leeneer, Jenny Lester, Douglas A Levine, Jingmei Li, Annika Lindblom, Jirong Long, Artitaya Lophatananon, Jennifer T Loud, Karen Lu, Jan Lubinski, Arto Mannermaa, Siranoush Manoukian, Loic Le Marchand, Sara Margolin, Frederik Marme, Leon F A G Massuger, Keitaro Matsuo, Sylvie Mazoyer, Lesley Mcguffog, Catriona Mclean, Iain Mcneish, Alfons Meindl, Usha Menon, Arjen R Mensenkamp, Roger L Milne, Marco Montagna, Kirsten B Moysich, Kenneth Muir, Anna Marie Mulligan, Katherine L Nathanson, Roberta B Ness, Susan L Neuhausen, Heli Nevanlinna, Silje Nord, Robert L Nussbaum, Kunle Odunsi, Kenneth Offit, Edith Olah, Olufunmilayo I Olopade, Janet E Olson, Curtis Olswold, David O'Malley, Irene Orlow, Nick Orr, Ana Osorio, Sue Kyung Park, Celeste L Pearce, Tanja Pejovic, Paolo Peterlongo, Georg Pfeiler, Catherine M Phelan, Elizabeth M Poole, Katri Pylkäs, Paolo Radice, Johanna Rantala, Muhammad Usman Rashid, Gad Rennert, Valerie Rhenius, Kerstin Rhiem, Harvey A Risch, Gus Rodriguez, Mary Anne Rossing, Anja Rudolph, Helga B Salvesen, Suleeporn Sangrajrang, Elinor J Sawyer, Joellen M Schildkraut, Marjanka K Schmidt, Rita K Schmutzler, Thomas A Sellers, Caroline Seynaeve, Mitul Shah, Chen-Yang Shen, Xiao-Ou Shu, Weiva Sieh, Christian F Singer, Olga M Sinilnikova, Susan Slager, Honglin Song, Penny Soucy, Melissa C Southey, Marie Stenmark-Askmalm, Dominique Stoppa-Lyonnet, Christian Sutter, Anthony Swerdlow, Sandrine Tchatchou, Manuel R Teixeira, Soo H Teo, Kathryn L Terry, Mary Beth Terry, Mads Thomassen, Maria Grazia Tibiletti, Laima Tihomirova, Silvia Tognazzo, Amanda Ewart Toland, Ian Tomlinson, Diana Torres, Thérèse Truong, Chiu-Chen Tseng, Nadine Tung, Shelley S Tworoger, Celine Vachon, Ans M W Van Den Ouweland, Helena C Van Doorn, Elizabeth J Van Rensburg, Laura J Van't Veer, Adriaan Vanderstichele, Ignace Vergote, Joseph Vijai, Qin Wang, Shan Wang-Gohrke, Jeffrey N Weitzel, Nicolas Wentzensen, Alice S Whittemore, Hans Wildiers, Robert Winqvist, Anna H Wu, Drakoulis Yannoukakos, Sook-Yee Yoon, Jyh-Cherng Yu, Wei Zheng, Ying Zheng, Kum Kum Khanna, Jacques Simard, Alvaro N Monteiro, Juliet D French, Fergus J Couch, Matthew L Freedman, Douglas F Easton, Alison M Dunning, Paul D Pharoah, Stacey L Edwards, Georgia Chenevix-Trench, Antonis C Antoniou, Simon A Gayther

Faculty, Staff and Student Publications

No abstract provided.

Increased Risk Of Postoperative Complications In Patients With Hypertension Undergoing Mohs Micrographic Surgery, Alexandra Elder, Henry Yang, Megan O'Donnell-Capelli, Jenna Mandel, Molly Wallace, Lauren Banner, Ramsay Hafer, Thomas Rohan, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

Hypertension has been previously associated with higher intraoperative bleeding risk in patients undergoing Mohs micrographic surgery. However, the risks of common postoperative Mohs micrographic surgery complications have not been substantiated by large studies. Our study aimed to assess the risks of common Mohs micrographic surgery complications for patients with hypertension utilizing the TriNetX database, a global health records database encompassing over 105 million patients' data, from January 2009 to January 2024. After 1:1 propensity score matching for age, sex, race, diabetes, nicotine dependence, obesity, and anticoagulant use, the final analysis included 80,739 patients in each cohort of patients with hypertension …

Analysis Of Health Policy Impacts On Adolescent Tobacco And Alcohol Consumption In Asean: An Ecological Descriptive Study, Marzalyla Putri Hendriansyah, Syifa Azzahra Setiawan, Sabrina Aprilia Putri, Falah Nur Chusniati, Rizka Maulida

Journal of Indonesian Health Policy and Administration

The prevalence of tobacco and alcohol consumption among adolescents in Southeast Asia remains a public health concern despite the introduction of several national policies. This study assessed the relationship between policy implementation and consumption trends of tobacco and alcohol in selected ASEAN countries. Using a descriptive ecological design, we analyzed secondary data from the Global School-based Student Health Survey (GSHS) and policy documents from official government sources. We observed a rise in tobacco consumption in Indonesia (+4.2%) and Brunei (+5.5%), while Thailand experienced a slight increase (+0.3%). Conversely, alcohol consumption decreased marginally in Indonesia (-0.7%) and Brunei (-0.8%), but increased …

The Effects Of Input And Characteristic Factors On Contact Rate Achievement Among Puskesmas In Indonesia, Iqbal Andri Makarim, Pujiyanto Pujiyanto

Journal of Indonesian Health Policy and Administration

The contact rate is the lowest-performing indicator in the Performance-Based Capitation Payment system initiated by BPJS Kesehatan. Analysis of the 2019 National Health Facility Research (Rifaskes) data showed that less than half of Puskesmas in Indonesia achieved the target. This cross-sectional study analyzed 5,384 Puskesmas from the 2019 Rifaskes to examine the effect of input and characteristic factors on achieving the contact rate. Independent variables included health worker ratios (doctors, nurses, midwives per 5,000 participants), completeness of essential medical equipment, communication facilities, P-Care application use, and Puskesmas characteristics. Multivariate logistic regression identified four significant factors: doctor ratio (OR=1.06; p<0.0001), midwife ratio (OR=1.01; p=0.033), completeness of essential medical equipment (OR=1.16; p=0.029), and BLUD-based financial management (OR=1.13; p=0.029). These factors explained only 2.6% of the variance (Nagelkerke R²=0.026), suggesting other unmeasured influences. Policy implications include equitable distribution of health personnel, targeted procurement of essential equipment, strengthening financial autonomy through BLUD, and optimizing P-Care data utilization to improve service accessibility and performance.

Gene Context Drift Identifies Drug Targets To Mitigate Cancer Treatment Resistance, Amir Jassim, Birgit V Nimmervoll, Sabrina Terranova, Erica Nathan, Linda Hu, Jessica T Taylor, Katherine E Masih, Lisa Ruff, Matilde Duarte, Elizabeth Cooper, Gunjan Katyal, Melika Akhbari, Reuben J Gilbertson, Jennifer C Coleman, Joseph S Toker, Colton Terhune, Gabriel Balmus, Stephen P Jackson, Hailong Liu, Tao Jiang, Michael D Taylor, Kui Hua, Jean E Abraham, Mariella G Filbin, Anthony Hill, Anarita Patrizi, Neil Dani, Aviv Regev, Maria K Lehtinen, Richard J Gilbertson

Faculty, Staff and Students Publications

Cancer treatment often fails because combinations of different therapies evoke complex resistance mechanisms that are hard to predict. We introduce REsistance through COntext DRift (RECODR): a computational pipeline that combines co-expression graph networks of single-cell RNA sequencing profiles with a graph-embedding approach to measure changes in gene co-expression context during cancer treatment. RECODR is based on the idea that gene co-expression context, rather than expression level alone, reveals important information about treatment resistance. Analysis of tumors treated in preclinical and clinical trials using RECODR unmasked resistance mechanisms -invisible to existing computational approaches- enabling the design of highly effective combination treatments …

Results Of Tor001: An Open-Label Single Patient Study Using Targeted Bacteriophage Therapy For The Treatment Of A Chronic Urinary Tract Infection, Jonathan D Cook, Payton B Hooey, Keiko C Salazar, Justin R Clark, Umesh Jain, Carlos Fernando, Hanjeong Harvey, Alexander Cervantes, Stephanie Omagari, Udi Blankstein, Andrew M Kropinski, Alan R Davidson, Karen L Maxwell, Lori L Burrows, Austen L Terwilliger, Anthony W Maresso, Greg J German

Faculty, Staff and Students Publications

Chronic urinary tract infections are persistent bacterial infections with the potential to drive antibiotic resistance. Like other persistent bacterial infections, intracellular bacterial reservoirs and biofilm formation hinder the clearance of pathogens despite long courses of antibiotic therapy. New strategies for treatment of these persistent infections are needed. Here we describe the results of an open-label individual patient study using bacteriophage therapy to treat a chronic urinary tract infection in an immunocompetent 72-year-old woman without underlying urolithiasis or indwelling devices. We co-administered HP3.1, HP3, and ES19 bacteriophages with demonstrated in vitro activity via bladder instillation, orally, and as a topical formulation. …

Reasons For Maintaining The Classification Of Esmethadone As An Investigational Uncompetitive Nmdar Antagonist Rapid Antidepressant: Reply To Ferré And Michaelides, Sara De Martin, Stefano Comai, Andrea Mattarei, Thomas R Kosten, Frank J Vocci, Charles W Gorodetzky, Marco Pappagallo, Paolo L Manfredi

Faculty, Staff and Students Publications

No abstract provided.

Integrative Analysis Of Lung Adenocarcinoma Across Diverse Ethnicities And Exposures, Shankha Satpathy, Natalie M Clark, Yi-Ju Chen, Noshad Hosseini, Ya-Hsuan Chang, Yi Hsiao, Jonathan T Lei, Francesca Petralia, Jin-Shing Chen, Yifat Geffen, David I Heiman, Indranil Paul, Hanbyul Cho, Michelle Hollenberg, Giacomo B Marino, Kuen-Tyng Lin, Rahul Mannan, C Jackson White, Joe Allen, Shayan C Avanessian, M Harry Kane, Ashley Wolfe, Miloni Kinarivala, Wenke Liu, Shankara Anand, Mong-Wei Lin, Moe Haines, Erik J Bergstrom, Grant Hussey, Ginny Xiaohe Li, Deepak C Mani, Hao Fang, Eric J Jaehnig, Hasmik Keshishian, Brecca Miller, Kang-Yi Su, Yi-Jing Hsiao, Hsao-Hsun Hsu, Min-Shu Hsieh, Kuo-Hsuan Hsu, Alexi Monovoukas, Simone Gohsman, John R Thorup, Yamei Deng, Yo Akiyama, Eden Deng, Eric Sheng-Wen Chen, Azra Krek, Rodrigo Espinoza, Weiping Ma, Daniel Charytonowicz, Robert Sebra, Jyun-Hong Lin, Yan-Si Chen, Yin-Chen Hsu, Ze-Shiang Lin, Kun-Chieh Chen, Chang-Wei Yeh, Yu-Tai Wang, Alexander J Lazar, Mehdi Mesri, Eunkyung An, Xu Zhang, Karl R Clauser, David Fenyö, Arul M Chinnaiyan, Bing Zhang, Li Ding, Kelly Ruggles, Chelsea Newton, Hui Zhang, Pei Wang, Galen Hostetter, Gilbert S Omenn, Chandan Kumar-Sinha, Mathangi Thiagarajan, Ramaswamy Govindan, Paul Paik, Abhijit Parolia, Qing K Li, Avi Ma'ayan, Gad A Getz, Saravana M Dhanasekaran, Ana I Robles, Gee-Chen Chang, Pan-Chyr Yang, Sung-Liang Yu, Hsuan-Yu Chen, Alexey I Nesvizhskii, Steven A Carr, D R Mani, Marcin P Cieslik, Yu-Ju Chen, Michael A Gillette, Taiwan Cancer Moonshot Program, Clinical Proteomic Tumor Analysis Consortium

Faculty, Staff and Students Publications

Lung adenocarcinomas (LUAD) are a pressing global health problem with enduring lethality and rapidly shifting epidemiology. Proteogenomic studies integrating proteomics and post-translational modifications with genomics can identify clinical strata and oncogenic mechanisms, but have been underpowered to examine effects of ethnicity, smoking and environmental exposures, or sex on this heterogeneous disease. This comprehensive proteogenomic analysis of LUAD tumors and matched normal adjacent tissues from 406 patients across diverse geographic and demographic backgrounds explores the impact of understudied driver mutations, prognostic role of chromosomal instability, patterns of immune signaling, differential and sex-specific effects of endogenous mutagens and environmental carcinogens, and pathobiology …