Digital Commons Network^™

Climate Change: The World In Uncharted Waters – Exploring The Nexus Of Human-Rights Based Legal Instruments And Climate Change, Emma V. Wilson

Richmond Public Interest Law Review

The framework of human rights is based on a “fundamental and irrevoca- ble belief in the dignity and worth of every individual.”! While many differ- ent channels have emerged for protecting human rights in the face of global climate change, there is still significant room for improvement. For decades, there was no formal recognition of human-centered environmental rights.? The recent United Nations General Assembly (“UNGA”) acknowledgement of a right to a clean, healthy, and sustainable environment is a tool that can “facilitate the reconceptualization of human rights law to better adapt to the negative impacts of climate change.” It represents …

Academic Policies Committee Minutes Of The Academic Senate 2025-10-06, University Of Dayton. Academic Senate. Academic Policies Committee

All Committee Minutes

Approved minutes of a meeting of the Academic Policies Committee of the Academic Senate of the University of Dayton

Apoe-Calypse Tau: Apoe-Tau Synergy In Alzheimer's Disease, Matthew Paul Lennol, Chiara Bordier, Léana Kamelher, Jason D Ulrich, David M Holtzman, Maud Gratuze

2020-Current year OA Pubs

Alzheimer's disease (AD), the most common cause of dementia, is characterized by the accumulation of amyloid-β (Aβ) in senile plaques and abnormally hyperphosphorylated tau proteins in neurofibrillary tangles. While much of the research has focused on Aβ, tau-mediated neurodegeneration is more closely associated with synaptic loss and cognitive decline in AD, emphasizing the need for a deeper understanding of tau pathology. In this context, the interaction between tau and APOE, particularly the main genetic risk factor for AD APOE ε4, remains underexplored. APOE encodes apolipoprotein E (apoE), a protein important in lipid metabolism. In addition to promoting Aβ deposition, emerging …

Investigation Of Lncrna Expression In Newly Diagnosed Multiple Myeloma Reveals A Linc01432-Celf2 Axis As An Inhibitor Of Apoptosis, Richa Mishra, Prasanth Thunuguntla, Dhanusha Duraiyan, Alani Perkin, Katelyn Bagwill, Savannah Gonzales, Catheryn Sizemore, Vanessa Brizuela, Jaiyana King, Stephen Daly, Yoon Jae Chang, Mahdote Abebe, Yash Rajana, Kelly Wichmann, Christ Enyan, Shruthi Rangineni, Mark Fiala, Julie Fortier, Reyka Jayasinghe, Mark Schroeder, Li Ding, Ravi Vij, John Dipersio, Jessica Silva-Fisher

2020-Current year OA Pubs

Multiple myeloma (MM) is an incurable malignancy of plasma cells, with over 35,000 new cases diagnosed annually in the United States. Despite an expanding arsenal of approved therapies, nearly all patients relapse, and mechanisms underlying disease progression remain poorly understood. In particular, the role of long non-coding RNAs (lncRNAs) in MM progression and treatment response is largely unexplored. To address this gap, we performed transcriptome sequencing of newly diagnosed MM (NDMM) patient samples and compared individuals with short progression-free survival (PFS; < 24 months) to those with prolonged PFS (>24 months) following standard first-line therapy. We identified 157 lncRNAs upregulated in patients with short PFS, and prioritized the …

10.06.2025 Ored Connect, Liz Williamson

ORED Newsletter

• Field Fest
• AAAS Membership
• MIG Application Opportunity
• Contest to Promote Safe Lab Practices

The Free Press Vol. 57, Issue 4, 10-06-2025, Julz Levesque, Caraline Squires

Free Press, The

Shutdown Stalemate--College Dreams at Risk--The Portland Farmer's Market Is in Full Bloom--First Pingo of the School Year--Common Ground Country Fair--USM Honors POW-MIA Recognition Day with Flag Raising Ceremony

Examining Student Resource Choice, Perception, And Self-Regulation In A Flipped Undergraduate Microbiology Lecture Course, Sarah Sletten

Biomedical Sciences Faculty Publications

This study examines student resource choice, perceptions, and self-regulated learning (SRL) in preparation for a flipped undergraduate microbiology course. Drawing on Expectancy-Value Theory, the investigation explored whether students prefer video lectures or complete note sets for pre-class preparation, how SRL strategies evolve over time, and the relationship between flipped classroom perceptions and in-class engagement. Data were collected across multiple course units using surveys—including a modified Motivated Strategies for Learning Questionnaire—and analysis of resource selection and classroom participation. The results indicate a strong and increasing preference for slides over video lectures. Additionally, significant increases in higher-order cognitive strategies were observed alongside …

Improving Icu Nurses’ Knowledge Of Early Mobility Through An Educational Intervention, Mohini Chand

Walden Dissertations and Doctoral Studies

This doctoral project sought to close a critical knowledge gap in the implementation of early mobility (EM) practices among intensive care unit (ICU) nurses. Guided by the ADDIE instructional design model, the initiative centered on developing and delivering a six-week educational intervention aimed at enhancing nurses’ comprehension and application of EM strategies for critically ill patients. Despite robust evidence supporting EM’s role in mitigating ICU-acquired weakness, reducing delirium, and improving functional outcomes, its clinical adoption remained inconsistent prior to this intervention. The project was anchored by the practice-focused question: “To what extent does an educational intervention improve ICU nurses’ knowledge …

Prep-Related Medical, Structural And Institutional Mistrust Among A Socioeconomically Diverse Sample Of Black, Latine, Asian, And White Young Sexual Minority Men: Lived Experiences Of Intersectional Inequity, Jessica Jaiswal, Marybec Griffin, Steven Meanley, Jerel Ezell, Yahya Alnashri, Kevin Hascher, Benjamin Grin, Perry N. Halkitis

Faculty and Staff Publications

Mistrust among marginalized populations has been shown to negatively impact health behaviors and outcomes. Young sexual minority men (YSMM) experience many health inequities, including those related to HIV. Understanding how YSMM think about and experience medical, structural, and institutional mistrust is critical to effectively promoting engagement in preventive services like pre-exposure prophylaxis (PrEP). The study recruited 43 YSMM (ages 25-27) from diverse racial, ethnic, and socioeconomic backgrounds in New York City. Semi-structured interviews were conducted from July- November 2018 and focused on sexual health, HIV-related beliefs, PrEP, and experiences with healthcare systems and providers. Three main themes were identified: (1) …

Intouch Week Of October 6, 2025, New York Medical College

InTouch

• NYMC Goes Pink for Breast Cancer Awareness Month
• Summer Research Fellowships Empower Medical Students to Explore, Innovate, and Lead
• International Symposium on Adolescent and Young Adult NHL Has Far Reach
• A Look Inside NYMC with the 2025-2026 Social Media Ambassadors
• SOM Welcomes New Faculty
• Pet the Stress Away Brings Joy to NYMC
• Stay Warm with Savings on Hoodies
• In The Community: College Joins Forces at Westchester Heart Walk to Fight Heart Disease and Stroke
• In The Community: SHSP Students and Faculty Partner with the White Plains Youth Bureau for Community Health and Wellness Day
• Faculty Spotlight: Christopher Whitehurst, Ph.D., Cracks …

Effective Strategies Oil And Gas Business Organizations’ Project Managers Use To Complete Information Technology Projects, Kenneth Uwalaka

Walden Dissertations and Doctoral Studies

The inability to complete information technology (IT) projects remains a significant concern for project managers in oil and gas industry. These are keen on discovering effective strategies to successfully complete IT projects, as any failures could significantly impact their organization's revenue and future. Grounded in the strategic alignment model, the purpose of this qualitative pragmatic inquiry project was to identify and explore successful strategies project managers of oil and gas business organizations use to complete IT projects to avoid a negative impact on organizational revenue and survival. The participants included seven project managers from different oil and gas business organizations …

Dieticians’ Perceptions Of Pediatric Obesity Education In Children’S Hospitals Located In Northeast Maryland, Constance Bartu

Walden Dissertations and Doctoral Studies

Dieticians play a vital role in the fight against pediatric obesity in the United States. The purpose of this qualitative study was to explore dieticians’ perceptions of internal and external reinforcements and barriers to childhood obesity interventions in children’s hospitals within Northeast Maryland. The study was framed by the social cognitive theory described by Bandura. As applied to this study, the theory focuses on prevention and intervention strategies used by dieticians working in children’s hospitals while offering educational interventions and other health care services. Interviews were conducted with eight dieticians with a minimum of 4 years working in children’s hospitals …

Strategies To Improve Access To Clinical Informatics Specialist Consultations In An Acute Care Hospital System, Holli Miller

Walden Dissertations and Doctoral Studies

Access to clinical informatics specialist (CIS) consultations is essential for optimizing electronic health record (EHR) use in acute care hospital systems. Limited availability of CIS support contributes to clinician burnout, workflow inefficiencies, and patient safety risks. The purpose of this integrative review was to identify strategies to improve access to CIS consultations in acute care settings. A comprehensive literature search across multiple databases yielded 656 articles, with 24 meeting inclusion criteria based on relevance and methodological rigor, evaluated using the Johns Hopkins Nursing Evidence-Based Practice appraisal tools. These studies, published between 2019 and 2024, underwent thematic analysis guided by the …

Perceptions Of Whole Plant-Based Diets And Weight Among Hispanics In Miami, Florida, Zoraida Powell

Walden Dissertations and Doctoral Studies

Being overweight or obese poses major public health concerns and contributes to the development of chronic illnesses. While researchers have explored how a total plant-based diet impacts excess body weight or obesity, there is still a lack of clarity about how Hispanics living in Miami, FL, perceive or understand this diet concerning overweight and obesity. Using a generic qualitative approach, this study was conducted on how Hispanics in Miami, FL, understand and view a whole plant-based diet (WPBD) for preventing and reducing overweight and obesity. Through interviews with 14 diverse Hispanic participants, the study revealed that they see WPBD as …

Rurality’S Impact On Alaska Native Elders’ Levels Of Physical Activity And Obesity, Jessie Doherty

Walden Dissertations and Doctoral Studies

While there have been studies on obesity levels and physical activity levels across many populations and age groups, few studies have focused on Alaska Native Elders. The purpose of this study was to examine rurality (urban vs. rural counties), physical activity, and obesity level while controlling for sex, self-reported loneliness, and self-reported stress. The theoretical foundation for this study was based on the socio-ecological model (SEM), and the research questions in this study explored how rurality impacted obesity levels and how rurality impacted physical activity levels in Alaska Native Elders. The methodology of this study was a quantitative cross-sectional design …

Effective Organizational Succession Planning Strategies For Retaining Knowledge From Retiring Employees, Rodriquez Tremayne Brown

Walden Dissertations and Doctoral Studies

A lack of succession planning to retain critical knowledge from retiring employees poses significant risks to organizational revenue and long-term survival. Organizational leaders are particularly concerned about succession planning because failure to capture employee knowledge threatens organizational performance and survival. Grounded in the 7-step model for succession planning theory, the purpose of this qualitative pragmatic inquiry project was to identify and explore effective succession planning strategies that some organizational leaders use to retain knowledge from retiring employees to avoid a negative impact on organizational revenue and survival. The participants included eight senior human resource managers from different organizations in the …

An Examination Of Successful Reentry And Recidivism For Drug-Involved Offenders In Rural Areas, Jacqueline Cottle

Walden Dissertations and Doctoral Studies

In rural communities, treatment and supportive resources are limited, putting ex-offenders (EXOs) at an increased risk for relapse or recidivism. The purpose of this qualitative study was to understand, through semistructured interviews, the experiences of EXOs who completed the court residential treatment center, intermediate sanction facility, or substance abuse felony punishment facility, and returned to a rural county in Texas, along with the perspectives of 11 community supervision officers who worked closely with the EXOs. This study was guided by Agnew’s general strain theory, which posits that drug-involved offenders achieve successful reentry in rural areas when positive supports are present, …

Rescue Epilepsy Medication And Training: A Comparison Between Midazolam Use, Guidelines, Clinical Practice, And Possibilities In The Uk And Norway, Rohit Shankar

Peninsula Medical School

Objectives: Status epilepticus (SE) is a prolonged epileptic seizure carrying significant risk of long-term disability and death. Rescue therapies are prescribedfor prehospital administration to terminate SE. This study compared prescribingpractices of rescue therapies of midazolam in the UK and Norway.Methods: A cross-sectional, online, 21-item Likert-style survey was administeredto epilepsy professionals in the UK circulated via ILAE/ESNA and in Norway viaILAE/Epilepsinet using a non-discriminatory exponential snowballing techniqueleading to non-probability sampling. Data were collected anonymously and analyzed using descriptive statistics, Mann–Whitney, Chi-square, and Fisher's exact tests. Significance was accepted at p<0.05.Results: All 86 UK and 53 Norway respondents identified buccal midazolam as the first-line rescue medication choice in the community for prolonged and/or generalized tonic–clonic seizures. Norwegian respondents had significantly more experience in epilepsy-related work (p=0.002), were more likely to have a larger caseload on buccal midazolam (p<0.001), prescribed higher midazolam doses (p<0.001), and provided training yearly (p<0.001). UK respondents were more likely to delegate rescue medication prescribing to primary care (p=0.006) and reviewed emergency management plans more frequently (p=0.006). There was an inter-country difference in the period of midazolam non-use that respondents required before withdrawing from treatment plans (p<0.001). Concern about inappropriate use of buccal midazolam was similarly high in both countries.Significance: This study compared epilepsy professionals in two neighboringhigh-income countries. Findings suggest an urgent need for international guidelines to recommend best practices on prescribing doses and withdrawal of buccal midazolam. The potential abuse of buccal midazolam by patients and carers warrants further investigation.

Phytochemisty And Antioxidant Activity Of Ethanol, Ethyl Acetate, And N-Hexane Extracts Of Suruhan Leaves (Peperomia Pellucida), Ade Arsianti, Steven Gill, Diyah Kristanty

Indonesian Journal of Medical Chemistry and Bioinformatics

Background: Free radicals are natural byproducts of cellular metabolism, in which, their excessive accumulation can lead to oxidative stress, which plays a key role in the development of various chronic diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions. Antioxidants are compounds capable of scavenging free radicals and minimizing oxidative damage. Peperomia pellucida, commonly known as Suruhan leaves, is a tropical herb traditionally used in folk medicine that contain bioactive compounds correlated with a strong radical-scavenging activity, suggesting its potential as a natural antioxidant source. This study aims to conduct a phytochemical analysis and evaluate the antioxidant activity of ethanol, …

The Rider (2025-10-06), Daniela Martinez Salazar

The Rider Archives

Vol. 11, No. 6

Retrospective, Single-Center Assessment Of A Pharmacist-Led Anti-Methicillin-Resistant Staphylococcus Aureus (Mrsa) Therapy Bundle To Enhance Antimicrobial Stewardship, Jeyma Fernandez, Alice Margulis Landayan, Jorge Murillo, Stephen Breazeale, Timothy Gauthier

All Publications

No abstract provided.

Re: Butte Priority Soils Operable Unit (Bpsou) Final Reclamation Improvement Sites Field Sampling And Investigation Plan (Fsp): Bres No. 45 – Garfield, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Atg16l1 Controls Mammalian Vacuolar Proton Atpase, Thabata L A Duque, Masroor Paddar, Einar Trosdal, Ruheena Javed, Lee Allers, Michal H Mudd, Prithvi Akepati, Soumya R Mishra, Michelle Salemi, Brett Phinney, Shawn B Bratton, Thomas Wileman, Vojo Deretic

Faculty, Staff and Student Publications

The mechanisms governing mammalian proton pump V-ATPase function are of fundamental and medical interest. The assembly and disassembly of cytoplasmic V1 domain with the membrane-embedded V0 domain of V-ATPase is a key aspect of V-ATPase localization and function. Here, we show that the mammalian protein ATG16L1, primarily appreciated for its role in canonical autophagy and in noncanonical membrane atg8ylation processes, controls V-ATPase. ATG16L1 knockout elevated V-ATPase activity, increased V1 presence on endomembranes, and increased the number of acidified intracellular compartments. ATG16L1's ability to efficiently bind V-ATPase was required for its inhibitory role in endolysosomal acidification and for control of Mycobacterium …

Squamous Non-Small Cell Lung Cancer: Current And Emerging Treatment Options, Paul K Paik, Jianjun Zhang, Howard Jack West, Jonathan W Riess

Faculty, Staff and Student Publications

Although the pharmacologic management of non-small cell lung cancer (NSCLC) has advanced substantially in the past 2 decades, disparities in the applicability to different histologic subtypes remain. Several treatment options are not suitable for squamous NSCLC, with use restricted to nonsquamous NSCLC (eg, bevacizumab and pemetrexed) because of safety concerns or comparative activity. Differences in mutational landscapes and a lack of matched targeted therapies specific to squamous NSCLC oncogenic aberrations present additional limitations. In the absence of suitable targeted therapies, immunotherapy with or without chemotherapy is the mainstay of squamous NSCLC treatment; however, survival-related outcomes remain poorer for patients with …

Inflammation And Mutational Burden Differentially Associated With Nivolumab Or Ipilimumab Combination Efficacy In Colorectal Cancer, Ming Lei, Michael J Overman, Jin Yao, Thierry André, Sara Lonardi, Heinz-Josef Lenz, Massimo Aglietta, Fabio Gelsomino, Ray Mcdermott, Ka Yeung Mark Wong, Michael A Morse, Eric Van Cutsem, Alain Hendlisz, Dana B Cardin, Bart Neyns, Andrew Hill, Anuradha Krishnamurthy, Franklin Chen, Samith Kochuparambil, Robert R Jenq, Sandzhar Abdullaev, Beilei He, Ruslan Novosiadly, Scott Kopetz

Faculty, Staff and Student Publications

Nivolumab alone and in combination with ipilimumab demonstrated durable clinical benefit in patients with previously treated microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer in the phase 2 CheckMate 142 study. Here, we report exploratory biomarker analyses from CheckMate 142 evaluating associations between various tissue biomarkers and the efficacy of nivolumab monotherapy and nivolumab plus ipilimumab combination in these patients. Higher expression of inflammation-related gene expression signatures is associated with improved response per investigator assessment and survival benefit with nivolumab monotherapy. In contrast, higher tumor mutational burden, tumor indel burden, and degrees of microsatellite instability are associated with improved response per investigator …

Quantitative Proteomics Identifies Conserved Proteins And Altered Regulation Of Mucin-16 In Low Grade Serous Ovarian Cancers, Christopher M Tarney, Paulette Mhawech-Fauceglia, Jonathan D Ogata, Julie Oliver, Tamara Abulez, Philip A Branton, Saeid Movahedi-Lankarani, Brian L Hood, Kelly A Conrads, Kendal Rosalik, Kwong-Kwok Wong, David M Gershenson, Sanghoon Lee, Anil K Sood, Robert C Bast, Kathleen M Darcy, Neil T Phippen, G Larry Maxwell, Thomas P Conrads, Nicholas W Bateman

Faculty, Staff and Student Publications

BACKGROUND: Low-grade serous ovarian carcinoma (LGSOC) is a rare and largely chemoresistant subtype of epithelial ovarian cancer. Unlike treatment for high-grade serous ovarian cancer (HGSOC), management options for LGSOC patients are limited, in part, due to a lack of deep molecular characterization of this disease. To address this limitation, we aimed to define highly conserved proteome alterations in LGSOC by performing deep quantitative proteomic analysis of tumors collected from LGSOC and HGSOC patients or normal fallopian tube tissues and validating proteins within two independent proteomic datasets of LGSOC and HGSOC tumors.

METHODS: Formalin-fixed, paraffin-embedded LGSOC (n = 12), HGSOC (n …

Assessing A Community Health Worker-Facilitated, Digitally Delivered, Family-Centered Diabetes Management Program: Single-Arm Quasi-Experimental Study, Zenong Yin, Vanessa L Errisuriz, Heather Cuevas, Bertha E Flores, Laura Delfausse, Christina Galvan, Jing Wang, Chengdong Li, Renata Morfin, Shiyu Li, Maysa Sapargeldiyeva, Giliane Yza Muyna, Minyu Zhang, Vanessa Sweet, Deborah Parra-Medina

Faculty, Staff and Student Publications

Background: The high prevalence of type 2 diabetes (T2D) and associated complications disproportionately affect low-income Latino populations, who also experience disparities in diabetes self-management (DSM), including poor medication adherence, physical activity, diet, and glycemic control.

Objective: This study examined, through an academic-community partnership, the effectiveness of ¡Salud, Salud! (an evidence-based, family-centered diabetes self-management education and support [DSMES] program) on primary (glycemic control and quality of life) and secondary (social, psychological, and behavioral factors related to T2D management) outcomes among low-income Latino adults with T2D or prediabetes.

Methods: In total, 81 adults (mean age 48.90 years, SD 12.57; n=57, 70.4%, female; …

Exploring The Correlation Between Pupil Distance And Myopia Prevalence: An Observational Bioanthropology Study In Surabaya, Anggitha Hayuning Kinasih, Dwi Martha Nur Aditya, Y Adhimas Setyo Wicaksono

Folia Medica Indonesiana

Bioanthropology integrates biological and cultural perspectives, thereby enhancing our understanding of human health across populations. Myopia is a significant refractive error affecting potentially 2.5 billion people globally by the end of the decade. Bioanthropological theories suggest that pupil diameter and distance contribute to axial elongation and the progression of myopia. Nevertheless, current literature lacks empirical validation through rigorous hypothesis testing, highlighting a gap in comprehension. The research explores the relationship between pupil distance and the incidence of myopia via empirical assessments in Surabaya. An observational cross-sectional study was conducted, which involved pupil distance measurements and eye refraction assessments. Inclusion criteria …

Practicing With Intent: How To Teach An Old Dogma New Tricks, Matthew C Phillips, Kusha Davar, Sarah Freling, Steven Y C Tong, Todd C Lee, Emily G Mcdonald, Travis B Nielsen, Noah Wald-Dickler, Alfredo J Mena Lora, Rachael A Lee, Fergus Hamilton, Daniel M Musher, Rodrigo P L Costa, Bassam Ghanem, Rachel Baden, Brad Spellberg

Faculty, Staff and Students Publications

Clinicians are constantly bombarded with an onslaught of newly published data, yet they must make clinical decisions despite a dearth of clinical data. Sometimes, they may fall back on clinical practices entrenched by experience, unaware that they are upheld by dogmatic tradition rather than robust evidence. Ideally, the totality of evidence must be assessed and utilized for clinical decision-making, irrespective of entrenched orthodoxy. Here, we explore the questions, how much evidence is needed to revise established clinical practices and, more fundamentally, can data alone truly catalyze such shifts.

Atg Conjugation-Dependent/Independent Mechanisms Underlie Lysosomal Stress-Induced Tfeb Regulation, Shiori Akayama, Takayuki Shima, Tatsuya Kaminishi, Mengying Cui, Jlenia Monfregola, Kohei Nishino, Andrea Ballabio, Hidetaka Kosako, Tamotsu Yoshimori, Shuhei Nakamura

Duncan NRI Faculty and Staff Publications

TFEB, a master regulator of autophagy and lysosomal biogenesis, is activated by several cellular stresses including lysosomal damage, but its underlying mechanism is unclear. TFEB activation during lysosomal damage depends on the ATG conjugation system, which mediates lipidation of ATG8 proteins. Here, we newly identify ATG conjugation-independent TFEB regulation that precedes ATG conjugation-dependent regulation, designated Modes I and II, respectively. We reveal unique regulators of TFEB in each mode: APEX1 in Mode I and CCT7 and/or TRIP6 in Mode II. APEX1 interacts with TFEB independently of the ATG conjugation system, and is required for TFEB stability, while both CCT7 and …