Digital Commons Network^™

Quiescent Oxphos-High Triple-Negative Breast Cancer Cells That Persist After Chemotherapy Depend On Bcl-Xl For Survival, Slawomir Andrzejewski, Marie Winter, Leandro Encarnacao Garcia, Olusiji Akinrinmade, Francisco Madeira Marques, Emmanouil Zacharioudakis, Anna Skwarska, Julio Aguirre-Ghiso, Marina Konopleva, Guangrong Zheng, Susan A Fineberg, Daohong Zhou, Evripidis Gavathiotis, Tao Wang, Eugen Dhimolea

Faculty, Staff and Student Publications

The persistent residual tumor cells that survive after chemotherapy are a major cause of treatment failure, but their survival mechanisms remain largely elusive. These cancer cells are typically characterized by a quiescent state with suppressed activity of MYC and MTOR. We observed that the MYC-suppressed persistent triple-negative breast cancer (TNBC) cells are metabolically flexible and can upregulate mitochondrial oxidative phosphorylation (OXPHOS) genes and respiratory function ("OXPHOS-high" cell state) in response to DNA-damaging anthracyclines such as doxorubicin, but not to taxanes. The elevated biomass and respiratory function of mitochondria in OXPHOS-high persistent cancer cells were associated with mitochondrial elongation and remodeling, …

Synthetically Expressive: Evaluating Gesture And Voice For Emotion And Empathy In Vr And 2d Scenarios, Haoyang Du, Kiran Chhatre, Christopher Peters, Brian Keegan, Rachel Mcdonnell, Cathy Ennis

Conference papers

The creation of virtual humans increasingly leverages automated synthesis of speech and gestures, enabling expressive, adaptable agents that effectively engage users. However, the independent development of voice and gesture generation technologies, alongside the growing popularity of virtual reality (VR), presents significant questions about the integration of these signals and their ability to convey emotional detail in immersive environments. In this paper, we evaluate the influence of real and synthetic gestures and speech, alongside varying levels of immersion (VR vs. 2D displays) and emotional contexts (positive, neutral, negative) on user perceptions. We investigate how immersion affects the perceived match between gestures …

Stock Market Reaction To Outbreak Of Covid-19: An Empirical Study Of Indian Sectoral Indices, Ruchita Verma, Dhanraj Sharma, Pranav Raghavan

Bulletin of Monetary Economics and Banking

The study examines COVID-19’s effect on the Indian stock market. According to the study’s findings, the pandemic significantly smashed Indian sectoral indices. The highest abnormal loss is observed in the Private Bank Index (-14.62 per cent) and the lowest in the Pharma Index (-6 per cent). The results of panel regression analysis depict that real return, profitability, and size have a substantial impact on the abnormal returns of the sectoral indices. The findings provide valuable insights to policymakers, to navigate market volatility and develop effective risk management strategies during pandemic.

The Social Impact Of Unconditional Cash Transfer: A Quasi-Experimental Approach, Andar Ristabet Hesda

Bulletin of Monetary Economics and Banking

This study investigates the social effects of the unconditional cash transfer program and analyzes the underlying mechanism. The empirical analysis indicates that those who consistently participated as program beneficiaries own greater social capital than those who did not maintain continuous enrollment in the program. One mechanism of this impact is enhanced personality, particularly in social behavior. Furthermore, the characteristic of social capital most impacted is heightened participation in communal activities. This study indicates that the program neither displaces private aid nor promotes altruism. These data contradict the claim that the targeted cash transfer program could incite societal discord by fostering …

Rtgs Determinant & Sub-Transaction Behavior During Covid-19 In Indonesia, Bastian Muzbar Zams, Akhmad Ginulur Pangersa, Gemala Srihati, Primitiva Febriarti, Nur Annisa Hasniawati

Bulletin of Monetary Economics and Banking

This paper investigates external factors affecting Indonesia’s Real Time Gross Settlement (RTGS) transactions by applying machine learning regularization to identify key variables from a large dataset. A Vector AutoRegression (VAR) model analyzes dynamic links among RTGS sub-transactions, while Impulse Response Function (IRF) analysis examines system behavior during COVID-19 shocks. Using monthly data on 75 economic indicators, we show that 21 variables most accurately capture the movement of Bank Indonesia Real Time Gross Settlement System (BIRTGS) transactions. The study shows that monetary operation sub-transactions most strongly affect other BI-RTGS sub-transactions. Impulse Response Function analysis also finds that shocks in customer transfers …

Bacillus Sp. Sw14 Isolated From Arid Mangroves Sediments Enhances Tomato Plant Growth: Insights From Genome Analysis And Greenhouse Evaluation, Balamurugan Sadaiappan, Qurban Ali, Mahideen Afridi, Munawwar Ali Khan, Sunil Mundra

All Works

Mangroves grow in arid regions with high temperatures, low precipitation, and evaporation. Despite low humidity and high salt concentration, these arid mangroves support diverse microorganisms, including salt-and temperature tolerant. The bacteria isolated from these arid mangroves have potential applications in arid agronomy, which alleviate plant stress and enhance plant growth. In this study, we characterize the genome of previously reported PGP and stress-tolerating bacteria, Bacillus sp. SW14, isolated from mangrove sediments of Umm Al Quwain, United Arab Emirates. Further, we investigated its effects on tomato seed germination and plant growth. Genome size of the strain SW14 is 4.25 MB, with …

Interoperability As A Catalyst For Digital Health And Therapeutics: A Scoping Review Of Emerging Technologies And Standards (2015–2025), Kola Adegoke, Abimbola Adegoke, Deborah Dawodu, Akorede Adekoya, Ayoola Bayowa

Health & Biomedical Sciences Faculty Publications

Background: Interoperability is fundamental for advancing digital health and digital therapeutics, particularly with the integration of technologies such as artificial intelligence (AI), blockchain, and federated learning. Low- and middle-income countries (LMICs), where digital infrastructure remains fragmented, face specific challenges in implementing standardized and scalable systems. Methods: This scoping review was conducted using the Arksey and O’Malley framework, refined by Levac et al., and the Joanna Briggs Institute guidelines. Five databases (PubMed, Scopus, IEEE Xplore, ACM Digital Library, and Google Scholar) were searched for peer-reviewed English language studies published between 2015 and 2025. We identified 255 potentially eligible articles and selected …

Documents From The October 8, 2025 Meeting Of The Associated Students Of The University Of Montana (Asum), Associated Students Of The University Of Montana, Kate Austin Payne

Senate Meeting Agendas and Minutes, 2007-Present

Agenda and meeting minutes from the October 8, 2025 meeting of the Associated Students of the University of Montana (ASUM).

Mechanistic Study Of Pexidartinib-Induced Toxicity In Human Hepatic Cells, Si Chen, Yuxi Li, Xilin Li, Nan Mei, Xiaobo He, Matthew S Bryant, Xuan Qin, Feng Li, Lei Guo

Faculty, Staff and Students Publications

Pexidartinib, a tyrosine kinase inhibitor, was approved by the U.S. Food and Drug Administration in 2019 for treating adult patients with symptomatic tenosynovial giant cell tumors. Because of its hepatotoxicity risks, pexidartinib received a boxed warning; however, mechanistic studies on this hepatotoxicity remain limited. In this study, we demonstrate that pexidartinib decreases cell viability in primary human hepatocytes and hepatic HepG2 cells. A 24-h treatment with pexidartinib led to apoptosis in HepG2 cells, as evidenced by increased caspase 3/7 activity and the induction of cleaved PARP and γ-H2A.X. Pexidartinib-induced endoplasmic reticulum (ER) stress was observed at early time points of …

One-Sided Matching Portal (Osmp): A Tool To Facilitate Rare Disease Patient Matchmaking., Matthew Osmond, E Magda Price, Orion J. Buske, Mackenzie Frew, Madeline Couse, Taila Hartley, Conor Klamann, Hannah G B H Le, Jenny Xu, Delvin So, Anjali Jain, Kevin Lu, Kevin Mo, Hannah Wyllie, Erika Wall, Hannah G. Driver, Warren A. Cheung, Ana S A Cohen, Emily G. Farrow, Isabelle Thiffault, Care Rare Canada Consortium, Andrei L. Turinsky, Tomi Pastinen, Michael Brudno, Kym M. Boycott

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Genomic matchmaking-the process of identifying individuals with overlapping phenotypes and rare variants in the same gene-is an important tool facilitating gene discoveries for unsolved rare genetic disease (RGD) patients. Current approaches are two-sided, meaning both patients being matched must have the same candidate gene flagged. This limits the number of RGD patients eligible for matchmaking. One-sided matchmaking, in which a gene of interest is queried in the genome-wide sequencing data of RGD patients, would make matchmaking possible for previously undiscoverable individuals. However, platforms and workflows for this approach have not been well established.

RESULT: We released a beta version …

Complications Of Ovarian Metastases From Well-Differentiated Small Bowel Neuroendocrine Neoplasms: A Focus On Bowel And Ureteral Obstruction, Sydney J. Wellens, Nicholas J. Skill, Kevin M. Sullivan, Mary A. Maluccio, Kristen E. Limbach

School of Medicine Faculty Publications

Ovarian metastasis from small bowel neuroendocrine neoplasms (SBNENs) was traditionally considered rare, but more recent series have suggested a higher prevalence. This case series seeks to examine the features and outcomes of patients with neuroendocrine ovarian metastases (NOM). Female patients with histologically confirmed well-differentiated SBNENs were identified using a prospectively maintained database (2014–2024). The electronic medical record was reviewed for details of diagnosis, histopathology, biomarkers, and outcomes among patients with and without NOM. 175 patients met inclusion criteria. 35 patients (20 %) had ovarian metastasis; for this group, 31.4 % had small bowel obstruction only, 5.7 % had ureteral obstruction …

Higher Mortality Following Sars-Cov-2 Infection In Rural Versus Urban Dwellers Persists For Two Years Post-Infection, A. Jerrod Anzalone, Michael T. Vest, Makayla E. Schissel, Bradley Price, William B. Hillegass, Ronald Horswell, San Chu, Clifford J. Rosen, Lucio Miele, Susan L. Santangelo, Gordon S. Smith, Sally L. Hodder, Christopher G. Chute

School of Medicine Faculty Publications

Previous studies demonstrated higher short-term mortality among rural compared with urban residents infected with SARS-CoV-2. However, whether this difference persists remains uncertain. This retrospective cohort study analyzed two-year post-COVID-19 mortality by rurality using the National Clinical Cohort Collaborative COVID-19 Enclave, a United States-based longitudinal electronic health record repository. We analyzed mortality among patients infected with SARS-CoV-2 between April 2020 and December 2022, with follow-up until December 2024. Patients were categorized into urban, urban-adjacent rural (UAR), and nonurban-adjacent rural (NAR) groups based on residential ZIP Code. Mortality differences were assessed using Kaplan-Meier analysis and weighted multivariable Cox regression, with weights derived …

A Case Of Granuloma Annulare Mimicking Candidal Intertrigo In The Groin, Scotty Smith, Patrice Perche, Leonard Gately

School of Medicine Faculty Publications

Granuloma annulare (GA) is a benign, non-infectious granulomatous skin condition of uncertain etiology, often presenting as annular erythematous plaques. While commonly localized to the hands and feet, GA has multiple clinical variants and can mimic other dermatologic conditions, leading to diagnostic challenges. We report a rare case of GA localized to the inguinal region in a 55-year-old female initially treated empirically for candidal intertrigo without improvement. Biopsy demonstrated interstitial histiocytic infiltrates dissecting between collagen bundles with increased dermal mucin, confirming a diagnosis of interstitial GA. The patient was subsequently treated with triamcinolone 0.1% ointment and hydroxychloroquine 200 mg twice daily …

Clinical Utility Of Diffusion Tensor Imaging In Sport-Related Concussion: A Systematic Review, Shiv Patil, Rithvik Kata, Serhat Aydin, Mert Karabacak, Konstantinos Margetis, Sotirios Bisdas

Student Papers, Posters & Projects

OBJECTIVE: Sport-related concussion (SRC) is a prevalent form of traumatic brain injury that is associated with long-term neurological and psychiatric impairment, particularly among athletes with a history of repetitive concussions. The biological variability of SRC's impact on the brain, as well as a lack of objective biomarkers to diagnose and prognosticate concussion, has prompted interest in advanced neuroimaging methods such as diffusion tensor imaging (DTI). By measuring disruptions in water diffusivity due to head trauma, DTI can detect alterations in white matter integrity that are not visualized by conventional imaging methods. This systematic review aims to synthesize major trends and …

Neighborhood Social Cohesion Associated With Chronic Liver Disease Prevalence And All-Cause Mortality, Tiange P. Zhang, Jennifer L. Dodge, Divya Ayyala-Somayajula, Norah A. Terrault

Division of Gastroenterology and Hepatology Faculty Papers

Background and Aims: Neighborhood social cohesion (NSC)—the degree of trust and solidarity within a community—may influence health through multiple pathways including shaping healthy norms, perception of safety, and stress. Whether NSC influences chronic liver disease (CLD) prevalence and associated mortality in the United States is unknown. Methods: Using 172,047 adults from the 2013–2018 National Health Interview Survey with linkage to National Death Index mortality data, NSC was measured using questions on help availability, accountability, trustworthiness, and connectedness among neighbors, with composite scores (4–16) categorized as minimal (4–7), low (8–10), moderate (11–13), and high (14–16). Logistic and Cox regression tested the …

What Can Bird Poop Teach Us About The History Of U.S. Imperialism?: Guano Islands And Manifest Destiny Beyond Continental Borders, Eliot Fackler

The Councilor: A National Journal of the Social Studies

In high school and college history courses, Manifest Destiny is often taught as a period when the United States expanded across the North American continent in the decades before the Civil War. This article outlines an inquiry-driven lesson examining the Antebellum guano rush and its devastating consequences to show that Manifest Destiny was also characterized by extracontinental imperial ambitions. It highlights the lasting impacts of the 1856 Guano Islands Act and links the guano rush to subsequent empire-building efforts, U.S. militarism, and ecological destruction. The article provides relevant background history, descriptions of possible class activities and assessments, and options for …

Navigating “Divisive” Issues In Social Studies Education: Practical Guidance For Teachers, Taylor M. Kessner, Sarah J. Kaka, Anthony Tuf Francis, Katrina Kennett

The Councilor: A National Journal of the Social Studies

Social studies classrooms and curricula have long been localized battlegrounds of broader cultural and political conflicts (Nash et al., 2000). These proxy conflicts—about what counts as history and whose history is taught to whom and why—have more recently evolved from brushfire conflicts to full-scale hot wars as local and state governmental actors have become more involved. Several state legislatures have introduced restrictions on teaching race, gender, and identity and increased demands for transparency in instructional content. More recently, in a 2024 executive order, President Donald Trump issued an executive order prohibiting governmental support for diversity, equity, inclusion, and justice efforts. …

2023 - Appalachian Student Research Forum Poster Award Winners, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2023 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

Bowers, Lawrence And Obergefell: A Case-By-Case Analysis, Hailey Moran

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

What does Bowers v. Hardwick, Lawrence v. Texas, and Obergefell v. Hodges all have in common? Each of these Supreme Court cases chronicles the passage of time and advancement in LGBTQ+ rights in America. Not only, however, do they chronicle the rights that have been achieved for LGBTQ+ individuals, but they also chronicle the evolution of the Justices on the bench. These cases here help us understand the influences that encourage the Justice’s decision-making, whether it be the state of the law or the Court’s environment. By analyzing each case, we can understand not only how these cases were decided, …

A Deep Dive Into The Nazis’ Animal World: Facilitating The Holocaust Through Symbolization, Filippa V. Frogner

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

This paper examines the use of animal symbolism in Nazi propaganda as a tool to dehumanize Jewish individuals and facilitate the Holocaust. Through an analysis of propaganda posters, films, and literature, it highlights how Jews were consistently depicted as animals such as rats, cockroaches, and monkeys—symbols associated with filth, disease, and inferiority. These portrayals, often reinforced by explicit textual messages, stripped Jews of their humanity and encouraged widespread acceptance of their persecution and extermination.

By exploring the methods, extent, and consequences of this dehumanizing propaganda, the paper sheds light on the critical role of animal symbolism in shaping public perception …

The Influence Of Religion On Gender Roles, Julianna R. Cutcher

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

Religion plays a pivotal role in shaping cultural norms, values, and power structures within societies. Religious discourse, as a socially constructed form of knowledge, defines gender roles, norms, and stereotypes, often reinforcing systems of privilege that favor straight, cisgender, white, and male individuals. This paper explores how religious teachings contribute to gender inequality, limiting opportunities for women and marginalized groups while enforcing rigid expectations of gender identity and sexual orientation. The analysis highlights the intersection of religion and power, exploring the topic through four lenses: systems of privilege and inequality, gender, social implications, and media and culture; it also presents …

Diverse Presentations Of Aphasia: A Comparative Analysis Of Polysynthetic And Analytic Languages Through Kanien'keha (Mohawk) And English Morphology And Syntax, Halle L. Elder

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

This paper looks to compare two linguistically diverse languages, English and Kanien'keha, a native American language commonly known as Mohawk. The comparison will revolve around the morphology and syntax typologies of these two languages. In addition to the morphological and syntactic comparison, I will discuss how aphasia presents itself in different language typologies, placing this comparison onto English and Kanien'keha. The research questions I look to answer are: How does word formation and sentence structure differ between English and Kanien'kéha? Does aphasia present differently in analytic and polysynthetic languages like English and Kanien'kéha? The morphological data and syntactic data are …

Review Of Fourierist Networks Of Reform: The Social Networks Of Nineteenth Century Reformers, Mitchell K. Jones

Communal Societies

No abstract provided.

Review Of Foodtopia: Communities In Pursuit Of Peace, Love & Homegrown Food, Etta M. Madden

Communal Societies

No abstract provided.

Interpersonal Elements Of Social Sustainability In Intentional Communities, Caitlyn R. Charles, Alison A. Ormsby

Communal Societies

No abstract provided.

Review Of The Business Of Marketing, Entrepreneurship, And Architecture Of Communal Societies In The 1960s And 1970s, Marc A. Rhorer

Communal Societies

No abstract provided.

Review Of How God Found Me: Memoirs Of An American Guru, Jennifer Greene

Communal Societies

No abstract provided.

The Value In Imperfect Endeavors: Exploring Postcapitalist And Prefigurative Practices At East Wind Intentional Community, Olivia Chandler

Communal Societies

No abstract provided.

Relationship Between Musculoskeletal Disorders And Productivity Loss Among Hospital Nurses: An Analytical Cross-Sectional Study With Secondary Data Analysis, Minkyung Kang, Inah Kim, Chang Park, Ari Min

Individual Articles

Aim: To identify the prevalence of musculoskeletal disorders among hospital nurses and explore their effects on productivity loss.

Design: An analytical cross-sectional study with secondary data analysis was conducted.

Methods: Data were collected via an online survey of 607 registered nurses working in general and tertiary hospitals in South Korea. Multivariate logistic regression analysis was performed to examine the association between musculoskeletal disorders and four productivity loss indicators: absenteeism, presenteeism, perceived productivity loss, and work limitations.

Results: Musculoskeletal disorders were highly prevalent among hospital nurses, with 83.9% of participants reporting muscu-loskeletal disorder symptoms in the past week. Lower back complaints …