Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 61561 - 61590 of 1791773

Full-Text Articles in Entire DC Network

Jose Montanez V. Paula Price Oct 2025

Jose Montanez V. Paula Price

2025 Decisions

USDC for the Middle District of Pennsylvania


October 8, 2025 Blazer Weekly, University Of Alabama At Birmingham Oct 2025

October 8, 2025 Blazer Weekly, University Of Alabama At Birmingham

Blazer Weekly (student newsletter)

No abstract provided.


Correction: Magnetized Chitosan Hydrogel And Silk Fibroin, Reinforced With Pva: A Novel Nanobiocomposite For Biomedical And Hyperthermia Applications, Reza Eivazzadeh-Keihan, Zeinab Pajoum, Hooman Aghamirza Moghim Aliabadi, Adibeh Mohammadi, Amir Kashtiaray, Milad Salimi Bani, Banafshe Pishva, Ali Maleki, Majid M. Heravi, Mohammad Mahdavi, Elaheh Ziaei Ziabari Oct 2025

Correction: Magnetized Chitosan Hydrogel And Silk Fibroin, Reinforced With Pva: A Novel Nanobiocomposite For Biomedical And Hyperthermia Applications, Reza Eivazzadeh-Keihan, Zeinab Pajoum, Hooman Aghamirza Moghim Aliabadi, Adibeh Mohammadi, Amir Kashtiaray, Milad Salimi Bani, Banafshe Pishva, Ali Maleki, Majid M. Heravi, Mohammad Mahdavi, Elaheh Ziaei Ziabari

Rothman Institute Papers

The authors regret that they omitted a citation to ref. 1 in their original article. This citation should be included in Section 3 (Result and discussion) before Section 3.1 (FT-IR spectroscopy and XRD analysis). The authors wish to add the following paragraphs to the discussion section of the original article, to be read in Section 3 (Result and discussion) before Section 3.1 (FT-IR spectroscopy and XRD analysis), after the sentence “.Finally, hyperthermia application was appraised and all results were evaluated.” in order to clarify the novelty of this work over ref. 1. In the previous work, we developed a multifunctional …


Daily Eastern News: October 08, 2025, Eastern Illinois University Oct 2025

Daily Eastern News: October 08, 2025, Eastern Illinois University

Daily Eastern News: 2025-2026

No abstract provided.


Enhancing Evidence-Based Practice: Board Vitals Resource Integration In Clinical Learning, Evelyn Wang Oct 2025

Enhancing Evidence-Based Practice: Board Vitals Resource Integration In Clinical Learning, Evelyn Wang

HSLIC Faculty and Staff Instructional Resources

This presentation was delivered at the Evidence-Based Practice Council Monthly Meeting, focusing on integration of Board Vitals, an online resource for medical and nursing exam preparation, into clinical learning. It highlights practical use of Board Vitals for clinician professional development and features resources for nurse practitioners, physician assistants, pharmacy, dental hygiene, radiology, USMLE, NCLEX, and more. The session covers access procedures, featured study materials, and library service links for advanced practice and nursing exam preparedness at UNM HSLIC.


Westport Ins Adversary Action Re: Coverage Oct 2025

Westport Ins Adversary Action Re: Coverage

Catholic Dioceses in Bankruptcy

No abstract provided.


Demographic And Biomechanical Factors Associated With Knee Excursion Angles Outside The Accepted Range, Karly Mendez Oct 2025

Demographic And Biomechanical Factors Associated With Knee Excursion Angles Outside The Accepted Range, Karly Mendez

Doctorate in Kinesiology

The knee is one of the most frequently injured musculoskeletal systems among long-distance runners, and these injuries may be explained by biomechanical inefficiencies and imbalances between the quadriceps and hamstrings. Common knee injuries in runners include patellofemoral pain syndrome, iliotibial band syndrome, and meniscal irritation. These injuries have the potential to interfere with training, reduce the number of races runners partake in, and affect performance in the long-term. The aim of this study was to investigate the relationship between quadriceps and hamstring strength and biomechanics of the knee involving long-distance runners experiencing knee pain or discomfort. Specifically, two-dimensional (2D) gait …


Re: Butte Priority Soil Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Bres No. 177 – North Alice Culvert, Mike Mcanulty Oct 2025

Re: Butte Priority Soil Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Bres No. 177 – North Alice Culvert, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Strengthening The Future: Sparking Growth And Connection Among Early Career Librarians, Alex Henigman, Brandon Kennedy Oct 2025

Strengthening The Future: Sparking Growth And Connection Among Early Career Librarians, Alex Henigman, Brandon Kennedy

Library Staff Publications

Description: This presentation highlights innovative programming created to support early career librarians as they develop and grow in their professional roles. Using a case study of an Early Career Librarian Task Force specifically for medical librarians, led by early career librarians themselves, it will showcase the programs developed, share lessons learned, and offer preliminary insights into the unique needs of early career librarians. Learning Objectives: The audience will gain insight into the needs of the next generation of librarians, learn about ways to support early career librarians at their library, and leave with practical guidance for creating their own social …


Pathologist-Like Explainable Ai For Interpretable Gleason Grading In Prostate Cancer, Gesa Mittmann, Nidia Messias, Et Al. Oct 2025

Pathologist-Like Explainable Ai For Interpretable Gleason Grading In Prostate Cancer, Gesa Mittmann, Nidia Messias, Et Al.

2020-Current year OA Pubs

No abstract provided.


Gabaergic Interneurons Contribute To The Fatal Seizure Phenotype Of Cln2 Disease Mice, Keigo Takahashi, Nicholas R. Rensing, Elizabeth M. Eultgen, Letitia L. Williams, Sophie H. Wang, Hemanth R. Nelvagal, Steven Q. Le, Marie S. Roberts, Balraj Doray, Edward B. Han, Patricia I. Dickson, Michael Wong, Mark S. Sands, Jonathan D. Cooper Oct 2025

Gabaergic Interneurons Contribute To The Fatal Seizure Phenotype Of Cln2 Disease Mice, Keigo Takahashi, Nicholas R. Rensing, Elizabeth M. Eultgen, Letitia L. Williams, Sophie H. Wang, Hemanth R. Nelvagal, Steven Q. Le, Marie S. Roberts, Balraj Doray, Edward B. Han, Patricia I. Dickson, Michael Wong, Mark S. Sands, Jonathan D. Cooper

2020-Current year OA Pubs

The cellular etiology of seizures in CLN2 disease, a childhood-onset neurodegenerative lysosomal storage disorder caused by a deficiency of tripeptidyl peptidase 1 (TPP1), remains elusive. Given that Cln2R207X/R207X mice display fatal spontaneous seizures and an early loss of several cortical GABAergic interneuron populations, we hypothesized that these 2 events might be causally related. To study the cell-autonomous effects of interneuron-specific TPP1 deficiency, we first generated transgenic mice expressing loxP-flanked lysosomal membrane-tethered TPP1 (TPP1LAMP1 mice) on the Cln2R207X/R207X genetic background, and then crossed TPP1LAMP1 mice with Vgat-Cre mice. These Vgat-Cre; TPP1LAMP1 mice accumulated storage material in cortical and striatal interneurons. Vgat-Cre; …


Transcriptional Responses Of Mouse Proximal Colon And Colonoids During Early Whipworm Infection, Hyeim Jung, Joseph F Urban, Bruce A Rosa, Makedonka Mitreva Oct 2025

Transcriptional Responses Of Mouse Proximal Colon And Colonoids During Early Whipworm Infection, Hyeim Jung, Joseph F Urban, Bruce A Rosa, Makedonka Mitreva

2020-Current year OA Pubs

Trichuriasis, caused by the parasitic nematode


Messages From The Provost, Georgia Southern University Oct 2025

Messages From The Provost, Georgia Southern University

Messages from the Provost

  • Message from the Provost
  • GS professor awarded NSF grant to advance protein imaging research

  • GS students partner with NASA to develop tech for deep-space missions

  • GS post-baccalaureate program helps next generation of coastal scientists wade into research

  • Fashion Merchandising student tailors her future following Tyler Perry Studios internship


Multimodal Reprogramming Of The Tumor Microenvironment By Mmr And Dual Checkpoint Blockade In Hepatocellular Carcinoma Models, Mulu Z. Tesfay, Aleksandra Cios, Khandoker Usran Ferdous, Randal S. Shelton, Bahaa Mustafa, Camila C. Simoes, Murat Gokden, Isabelle R. Miousse, Kimberly J. Krager, Marjan Boerma, Alicja Urbaniak, Anuradha Kunthur, Sri Obulareddy, Joshua M. Eichhorn, Steven R. Post, Jean Christopher Chamcheu, Omeed Moaven, Chiswili Y. Chabu, Dan G. Duda, Matteo Conti, Bruno Nardo, Rang Govindarajan, Martin E. Fernandez-Zapico, Lewis R. Roberts, Mitesh J. Borad, Martin J. Cannon, Alexei G. Basnakian, Bolni M. Nagalo Oct 2025

Multimodal Reprogramming Of The Tumor Microenvironment By Mmr And Dual Checkpoint Blockade In Hepatocellular Carcinoma Models, Mulu Z. Tesfay, Aleksandra Cios, Khandoker Usran Ferdous, Randal S. Shelton, Bahaa Mustafa, Camila C. Simoes, Murat Gokden, Isabelle R. Miousse, Kimberly J. Krager, Marjan Boerma, Alicja Urbaniak, Anuradha Kunthur, Sri Obulareddy, Joshua M. Eichhorn, Steven R. Post, Jean Christopher Chamcheu, Omeed Moaven, Chiswili Y. Chabu, Dan G. Duda, Matteo Conti, Bruno Nardo, Rang Govindarajan, Martin E. Fernandez-Zapico, Lewis R. Roberts, Mitesh J. Borad, Martin J. Cannon, Alexei G. Basnakian, Bolni M. Nagalo

School of Graduate Studies Faculty Publications

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, thus, there is an urgent need to develop more effective therapeutic options for this dismal condition. Tumor-infiltrating lymphocytes (TILs) are associated with improved response to immune checkpoint blockade in HCC, but their low abundance in most cases limits their therapeutic efficacy. Here, we demonstrate, in mice, that low-dose intratumoral immunovirotherapy with the trivalent measles, mumps, and rubella vaccine (MMR) induces superior tumor-growth delay and extended host survival compared to individually administered vaccines for measles, mumps, or rubella viruses. Further, our results show that MMR therapy synergizes with PD-1 and …


Synthetically Expressive: Evaluating Gesture And Voice For Emotion And Empathy In Vr And 2d Scenarios, Haoyang Du, Kiran Chhatre, Christopher Peters, Brian Keegan, Rachel Mcdonnell, Cathy Ennis Oct 2025

Synthetically Expressive: Evaluating Gesture And Voice For Emotion And Empathy In Vr And 2d Scenarios, Haoyang Du, Kiran Chhatre, Christopher Peters, Brian Keegan, Rachel Mcdonnell, Cathy Ennis

Research Outputs: 2025-Present

The creation of virtual humans increasingly leverages automated synthesis of speech and gestures, enabling expressive, adaptable agents that effectively engage users. However, the independent development of voice and gesture generation technologies, alongside the growing popularity of virtual reality (VR), presents significant questions about the integration of these signals and their ability to convey emotional detail in immersive environments. In this paper, we evaluate the influence of real and synthetic gestures and speech, alongside varying levels of immersion (VR vs. 2D displays) and emotional contexts (positive, neutral, negative) on user perceptions. We investigate how immersion affects the perceived match between gestures …


Comparison Of Anterior And Posterior Surgical Approaches For Cervical Ossification Of The Posterior Longitudinal Ligament Stratified By Spinal Levels: A Systematic Review And Meta-Analysis, Seyed Danial Alizadeh, Sepehr Khosravi, Farzin Farahbakhsh, Vali Baigi, Moein Khormali, Mohsen Hajiqasemi, Zahra Eskandari, Mahgol Sadat Hassan Zadeh Tabatabaei, Amirmahdi Khayyamfar, Mohammad-Rasoul Jalalifar, Sepehr Armaghan, Masoud Pourghahramani Koltapeh, Zahra Ghodsi, Michael G. Fehlings, Alex R. Vaccaro, Vafa Rahimi-Movaghar Oct 2025

Comparison Of Anterior And Posterior Surgical Approaches For Cervical Ossification Of The Posterior Longitudinal Ligament Stratified By Spinal Levels: A Systematic Review And Meta-Analysis, Seyed Danial Alizadeh, Sepehr Khosravi, Farzin Farahbakhsh, Vali Baigi, Moein Khormali, Mohsen Hajiqasemi, Zahra Eskandari, Mahgol Sadat Hassan Zadeh Tabatabaei, Amirmahdi Khayyamfar, Mohammad-Rasoul Jalalifar, Sepehr Armaghan, Masoud Pourghahramani Koltapeh, Zahra Ghodsi, Michael G. Fehlings, Alex R. Vaccaro, Vafa Rahimi-Movaghar

Rothman Institute Papers

OBJECTIVE: To compare the outcomes of anterior and posterior surgical approaches for treating cervical ossification of the posterior longitudinal ligament across multiple spinal levels, including 1-2 spinal levels, ≥ 3 levels, or studies that operated on both spinal levels, called mixed spinal levels.

METHODS: A search strategy using pertinent keywords was employed in the MEDLINE, Embase, Scopus, and Web of Science databases. Data on Modified Japanese Orthopaedic Association (mJOA) scores, radiographic outcomes, and complications were extracted. A random-effects meta-analysis, subgroup meta-analysis, and sensitivity analysis were performed.

RESULTS: Among 13 included studies, the anterior approach was statistically associated with improved C2-C7 …


Peer Education Programme To Improve Adolescent Sexual And Reproductive Health In Rwanda, Aimable Nkurunziza, Michael Habtu, Germaine Tuyisenge, Nadja Van Endert, Godfrey Katende, Assumpta Yamuragiye, Justine Bagirisano, B.H. Jean Hitayezu, Olive Tengera, Edward Rwagasore Oct 2025

Peer Education Programme To Improve Adolescent Sexual And Reproductive Health In Rwanda, Aimable Nkurunziza, Michael Habtu, Germaine Tuyisenge, Nadja Van Endert, Godfrey Katende, Assumpta Yamuragiye, Justine Bagirisano, B.H. Jean Hitayezu, Olive Tengera, Edward Rwagasore

School of Nursing & Midwifery, East Africa

Background: A peer education programme was developed in response to the tendency of high school students in Rwanda to seek sexual and reproductive health information from peers who are often inadequately informed.

Aim: To assess the effect of Sexual and Reproductive Health Peer Education Programme (SRH PEP) on knowledge and the attitudes of SRH among high school adolescents in Rwanda. Setting: The study was conducted at selected high schools in Rwanda.

Methods: This pre-test and post-test design study was conducted in two selected high schools. The pre-test data were collected in February 2020, followed by the post-test data in May …


Vavili Realty, Llc V. Vargas Oct 2025

Vavili Realty, Llc V. Vargas

All Decisions

In this holdover proceeding, the tenant moved to dismiss, arguing the landlord waived its right to enforce the no-pet provision under NYC Administrative Code § 27-2009.1. The tenant claimed openly and notoriously harboring a dog, and the landlord failed to commence an eviction proceeding within 90 days of knowledge. The court found the landlord's emails and notices proved actual knowledge of the pet's presence more than 90 days before commencing the suit. Consequently, the landlord waived its right to enforce the no-pet clause, and the tenant's motion to dismiss was granted.


Social Determinants Of Self-Reported Health In Vulnerable Populations During A Polycrisis In Lebanon, Rindala Fayyad, Marie Elizabeth Ragi, Hala Ghattas Ph.D., Stephen J. Mccall Oct 2025

Social Determinants Of Self-Reported Health In Vulnerable Populations During A Polycrisis In Lebanon, Rindala Fayyad, Marie Elizabeth Ragi, Hala Ghattas Ph.D., Stephen J. Mccall

Faculty Publications

Importance: In the context of a polycrisis, which is characterized by multiple interconnected and mutually reinforcing crises, humanitarian and health needs increase. It is therefore crucial to identify social determinants impacting health and well-being of vulnerable populations to better inform appropriate interventions.

Objective: To assess the association between social determinants and pain frequency, self-rated health, and depression over time among vulnerable populations during a polycrisis in Lebanon.

Design, Setting, and Participants: In this population-based longitudinal cohort study, data were collected in Sin-El-Fil, a suburb of Beirut, Lebanon, in 4 waves: June 28 to October 26, 2022; September 8 to December …


Disclosure And The Pace Of Drug Development, Colleen Cunnningham, Florian Ederer, Charles Hodgson, Zhichun Wang Oct 2025

Disclosure And The Pace Of Drug Development, Colleen Cunnningham, Florian Ederer, Charles Hodgson, Zhichun Wang

Cowles Foundation Discussion Papers

Policies that mandate disclosure of innovative project outcomes aim to increase innovation by limiting wasteful duplicative innovation. Yet, such policies change not only the ex-post information environment but also firms' ex-ante innovation incentives. Firms may slow down their own innovation efforts in anticipation of increased disclosure by others. We examine the innovation-related impacts of the 2017 FDA Final Rule amendment, which mandates disclosure of clinical trial results for pharmaceutical firms. We show that the policy hastened and increased disclosure of results for clinical trials post-completion, but also increased the time to completion of clinical trials, the time between early phases …


Hydroxyapatite Microspheres Induce Durable Pleurodesis And Are Rapidly Cleared By Pleural Osteoclasts, Yusuke Tanaka, Yuki Takahashi, Yuma Shindo, Lori B. Pitstick, Steven L. Teitelbaum, Wei Zou, Xiangning Wang, Jason C. Woods, Kathryn A. Wikenheiser-Brokamp, Francis X. Mccormack Oct 2025

Hydroxyapatite Microspheres Induce Durable Pleurodesis And Are Rapidly Cleared By Pleural Osteoclasts, Yusuke Tanaka, Yuki Takahashi, Yuma Shindo, Lori B. Pitstick, Steven L. Teitelbaum, Wei Zou, Xiangning Wang, Jason C. Woods, Kathryn A. Wikenheiser-Brokamp, Francis X. Mccormack

2020-Current year OA Pubs

Talc pleurodesis is highly effective for preventing recurrence of pneumothorax and pleural effusion, but it can be complicated by dissemination, acute lung injury, lead exposure, and foreign body-induced chronic inflammation and pain. Our objective is to develop a safe, biodegradable, contaminant-free particle for pleurodesis. We used mouse models of pneumothorax and malignant pleural effusion to compare the efficacy and safety of pleurodesis with talc and hydroxyapatite microspheres (HAM). Intrapleural instillation of microspheres induced pleural adhesions, fibrosis, and symphysis as effectively as talc and resulted in more durable protection from experimental pneumothorax. HAM and talc both induced an osteoclastogenic, inflammatory, and …


Completion Rates For Ecological Momentary Assessments Of Food Intake During Pregnancy And Post Partum: Descriptive Study, Sarah Annalise Sanders, Serwaa Omowale, Andrea Casas, Alexis Kiyanda, Abigail Smith Kosbie, Yu-Hsuan Lai, Meredith Wallace, Stephen Rathbun, Tiffany Gary-Webb, Esa Davis, Lora Burke, Dara Méndez Oct 2025

Completion Rates For Ecological Momentary Assessments Of Food Intake During Pregnancy And Post Partum: Descriptive Study, Sarah Annalise Sanders, Serwaa Omowale, Andrea Casas, Alexis Kiyanda, Abigail Smith Kosbie, Yu-Hsuan Lai, Meredith Wallace, Stephen Rathbun, Tiffany Gary-Webb, Esa Davis, Lora Burke, Dara Méndez

Faculty, Staff and Student Publications

Background: The collection of dietary behavior data is crucial in childbearing populations. In addition to observed inequities in perinatal dietary intake and quality, burdensome assessment methods (eg, 24-h dietary recall) may limit research participation for some groups. Ecological momentary assessment (EMA) is associated with reduced recall bias and participant convenience, but there is a dearth of studies with diverse cohorts.

Objective: Our aim is to describe participant completion of food intake items in EMA surveys, overall and across individual characteristics (eg, prepregnancy BMI).

Methods: Using secondary EMA data from participants in a longitudinal study, we report average completion rates of …


Spectrum, Volume 55, Issue 5, Sacred Heart University Oct 2025

Spectrum, Volume 55, Issue 5, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: SHU Alumni’s Film “Flyway of Life” -- Debut of the School of Performing Arts -- Joining the Brotherhood -- How Students are Tackling Financial Literacy -- Stepping into the Spotlight -- Six Pioneers Swim Towards Nationals


Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Ur- 19 – Butte, Anaconda & Pacific Railway From Montana Street To South Arizona Avenue – Montana Street Adjacent Parcel (Dated August 13, 2025), Molly Roby Oct 2025

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Ur- 19 – Butte, Anaconda & Pacific Railway From Montana Street To South Arizona Avenue – Montana Street Adjacent Parcel (Dated August 13, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Mental Health Week, Nyls Office Of Student Life, The Organization For Health Minds, Legal Association For Women, Restorative Justice Law Student Association Oct 2025

Mental Health Week, Nyls Office Of Student Life, The Organization For Health Minds, Legal Association For Women, Restorative Justice Law Student Association

Student Organizations

OCTOBER 8 – 14, 2025


Failure To Rescue After Surgery For Pancreatic Cancer: A Systematic Review And Narrative Synthesis Of Risk Factors And Safety Strategies, Masashi Uramatsu, Yoshikazu Fujisawa, Paul Barach, Hiroaki Osakabe, Moe Matsumoto, Yuichi Nagakawa Oct 2025

Failure To Rescue After Surgery For Pancreatic Cancer: A Systematic Review And Narrative Synthesis Of Risk Factors And Safety Strategies, Masashi Uramatsu, Yoshikazu Fujisawa, Paul Barach, Hiroaki Osakabe, Moe Matsumoto, Yuichi Nagakawa

College of Population Health Faculty Papers

Background: Failure to rescue (FTR), defined as death after major postoperative complications, is a critical quality indicator in pancreatic cancer surgery. Despite advances in surgical techniques and perioperative care, FTR rates remain high and vary across institutions. Methods: This systematic review uses a narrative synthesis followed by PRISMA 2020. A PubMed search (1992-2025) identified 83 studies; after screening, 52 studies (2010-2025) were included. Eligible designs were registry-based, multicenter, single-center, or prospective audits. Given substantial heterogeneity in study designs, FTR definitions, and outcome measures, a narrative synthesis was performed; no formal risk-of-bias assessment or meta-analysis was conducted. Results: …


Spartan Daily, October 8, 2025, San Jose State University, School Of Journalism And Mass Communications Oct 2025

Spartan Daily, October 8, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 20


A Neuroimmune Cerebral Assembloid Model To Study The Pathophysiology Of Familial Alzheimer's Disease, Andrea Becerra-Calixto, Anik Banerjee, Huihui Fan, Chunfeng Tan, Eunyoung Lee, Louise D Mccullough, Juneyoung Lee Oct 2025

A Neuroimmune Cerebral Assembloid Model To Study The Pathophysiology Of Familial Alzheimer's Disease, Andrea Becerra-Calixto, Anik Banerjee, Huihui Fan, Chunfeng Tan, Eunyoung Lee, Louise D Mccullough, Juneyoung Lee

Faculty, Staff and Student Publications

Alzheimer's disease (AD) is the leading cause of dementia globally. The accumulation of amyloid and tau proteins, neuronal cell death and neuroinflammation are seen with AD progression, resulting in memory and cognitive impairment. Microglia are crucial for AD progression as they engage with neural cells and protein aggregates to regulate amyloid pathology and neuroinflammation. Recent studies indicate that microglia contribute to the propagation of amyloid beta (Aβ) via their immunomodulatory functions including Aβ phagocytosis and inflammatory cytokine production. Three-dimensional cell culture techniques provide the opportunity to study pathophysiological changes in AD in human-derived samples that are difficult to recapitulate in …


Structural Variation, Selection, And Diversification Of The Npip Gene Family From The Human Pangenome., Philip C. Dishuck, Katherine M. Munson, Alexandra P. Lewis, Max L. Dougherty, Jason G. Underwood, William T. Harvey, Pinghsun Hsieh, Tomi Pastinen, Evan E. Eichler Oct 2025

Structural Variation, Selection, And Diversification Of The Npip Gene Family From The Human Pangenome., Philip C. Dishuck, Katherine M. Munson, Alexandra P. Lewis, Max L. Dougherty, Jason G. Underwood, William T. Harvey, Pinghsun Hsieh, Tomi Pastinen, Evan E. Eichler

Manuscripts, Articles, Book Chapters and Other Papers

The NPIP gene family is among the most positively selected gene families in humans/apes and drives independent duplication in primate lineages. These duplications promote genetic instability, leading to recurrent disease-associated microduplication and microdeletion syndromes. Despite its importance, little is known about its function or variation in humans, as short-read sequencing cannot distinguish high-identity duplications. Using long-read assemblies of 169 human haplotypes, we find extreme variation in the content and organization of NPIP loci. We identify fixed and polymorphic paralogs and observe ongoing positive selection. With long-read RNA sequencing (RNA-seq), we create paralog-specific gene models, the majority of which were not …


Synaptic Transmission Promotes Brain Metastatic Outgrowth In Breast Cancer, Jayanta Mondal, Patrick Nylund, Prit Benny Malgulwar, William E Johnson, Jason T Huse Oct 2025

Synaptic Transmission Promotes Brain Metastatic Outgrowth In Breast Cancer, Jayanta Mondal, Patrick Nylund, Prit Benny Malgulwar, William E Johnson, Jason T Huse

Faculty, Staff and Student Publications

This work demonstrates that normal neuron-to-neuron signaling machinery is hijacked by metastasizing cancer cells during their outgrowth in the central nervous system.