Digital Commons Network^™

Preparation, Characterization, And Evaluation Of The Antioxidant Activity Of Chitosan Nano-Particles, Sura M. Abbood, Zahraa Raheem Murshidy, Aziz Y. H. Al-Ethari

Baghdad Science Journal

Nanotechnology is considered as a modern technique which provides useful characteristics to the nanomaterial including small size with high biological activity and the possibility to obtain novel nano-biohybrids through combining efficient and safe transport carriers with biological molecules. The nanohybrid chitosan has important applications in the food industry, due to its biochemical properties, such as biocompatibility, biodegradability, non-toxicity. The goal of this research is to develop environmentally friendly, economically feasible and a simple prepared natural nanohybrid antioxidant instead of artificial one, which is a main characteristic on a food industrial scale. The sol-gel ion exchange method was used to prepare …

Mechanism Of Immunotherapeutic And Anticancer Effects Of Moringa Peregrina Seed Extract On Non-Small-Lung Cancer, Nci-H460, Cell Line, Shaymaa Fadhel Abbas Albaayit, Maryam Kamel Mohammed, Ali Muhsin Ali, Rukesh Maharjan, Lubna M. Rasoul, Rasedee Abdullah, Mohd Hezmee Mohd Noor

Baghdad Science Journal

The Moringa peregrina plant possesses various therapeutic properties. This study determined the immunomodulatory and cytotoxic activities of M. peregrina seed ethanol extract (MPSE). Based on using gas chromatography-mass spectrometry analysis MPSE is rich in flavonoids, isothiocyanate, tocopherols, triterpenoids, and phenolics compounds. The immunomodulatory effect of MPSE was determined on whole blood and polymorphonuclear (PMNs) cells and macrophages. The in vitro antiproliferative effect was determined on the non-small-cell lung cancer, NCI-H460, cell line. Real-time quantitative PCR and flow cytometry were used to determine the expression of apoptotic genes in the MPSE-treated NCI-H460 cells. MPSE significantly (p < 0.001) suppressed whole blood, PMN cells and macrophage ROS production with IC50 values of 40.3 ± 0.3, 33.0 ± 0.6, and 26.1 ± 0.43 μg/mL, respectively. MPSE …

Isolation And Purification Of Phytosterols From Euphorbia Milii Plant Cultivated In Iraq By Phplc And Evaluation Of Anticancer Activity, Z. O. Salman, Bushra M.J. Alwash, E. J. Kadhim

Baghdad Science Journal

Combined, plant sterols and stanols, substances structurally similar to cholesterol, are referred to as phytosterols. In plants, phytosterols serve the same purposes as cholesterol does in animals and people. This study’s primary goal was to compare two different cell line types to the extracted steroid and nano-steroid. PHPLC was used to isolate the novel steroid molecule from the Euphorbia milii plant in its pure form, and FT.IR was used to confirm its identity. The chemical had a retention time of 13.87. By using the chitosan-maleic complex process, nano-steroids were created. To evaluate produced nanoparticles, the Philips PW1730 XRD instrument was …

In Vitro And In Vivo Evaluation Of Autochthonous Probiotics And Their Effects On The Mucosal Health Of Nile Tilapia (Oreochromis Niloticus), Sherilyn T. Abarra, Sahya Maulu, Sheu G. Odu-Onikosi, Taofik A. Momoh, Benjamin Eynon, Matthew Emery, Mark Rawling, Daniel L. Merrifield

School of Biological and Marine Sciences

The host microbiome is a promising source of probiotics for aquaculture species including Nile tilapia. In this study, the probiotic potential of autochthonous bacterial isolates from Nile tilapia and carp mid-intestines were screened in vitro. Two isolates (C61 and T70), closely related to Bacillus subtilis, exhibited antagonistic activity against multiple pathogen species and demonstrated multiple digestive enzyme activities. Their antagonistic activity in Aeromonas hydrophila assays remained even under simulated intestinal juice (SIJ) exposure. Subsequently, C61 (PT1) and T70 (PT2) were added to experimental diets at log 7 CFU/g of diet, and fed to Nile tilapia (5.32 ± 0.12 g) for …

Shu World Review- November 15th 2025, Diplolab

SHU World Review

No abstract provided.

Elgie "Lj" Raymond

African American Funeral Programs

No abstract provided.

Applied Research In Field Crop Pathology For Indiana, 2024, Darcy E. P. Telenko, Sujoung Shim

Purdue University Press Books

Applied Research in Field Crop Pathology for Indiana, 2024 serves as a summary of the applied field crop pathology research trials conducted in 2024 under the direction of the Purdue Field Crop Pathology program in the Department of Botany and Plant Pathology at Purdue University. In Indiana, there are more than 57,600 farms, 16,000 crop producers, and 900 certified crop advisers, Extension educators, and crop-protection industry representatives who manage more than 11.4 million crop-production acres with a total value of $6.3 billion annually. There are more than twenty diseases affecting corn, soybeans, and wheat that may decrease crop production and …

Artificial Light At Night Alters Seaweed Reproductive Phenology, Emma Moyse, Louise Firth, Tim Smyth, Thomas Davies

School of Biological and Marine Sciences

Artificial light at night (ALAN) is a growing, globally prevalent environmental stressor. It is known to disrupt biological processes across taxa and biomes, including reproductive phenology in terrestrial plants, but its potential to alter reproductive timings in marine macroalgae remains unexplored. We used reflectance spectrometry to quantitatively assess changes in receptacle ripeness of three fucoid macroalgae species at four field sites along an ALAN gradient in Plymouth Sound, UK over a six-month period. At sites with elevated ALAN (measured using Sky Quality Meters, range 16.15–18.76 mag arcsec ⁻², equivalent to 3.75 × 10 ⁻²–3.38 × 10 ⁻³ cd/m …

Unveiling Novel Bladder Cancer Associations From Multicentred Primary And Secondary Care Electronic Health Records By Machine Learning: A Case-Control Study, Xu Wang, Andrea Preston, Jonathan Aning, Shang-Ming Zhou

School of Nursing and Midwifery

ObjectiveThe rising incidence and mortality in bladder cancer (BC) underscore the importance of identifying asscociated features. Current reliance on haematuria as a primary indicator for BC proves inadequate. While mining electronic health records (EHRs) offer potential of identifying BC-related signals, traditional data-driven methods struggle with high-dimensional datasets. This study aims to uncover novel BC-associated clinical signals by developing Parsimony-driven cAtegory-balaNced binary Signal extractor for Primary Care EHRs (PanSPICE) tailored to extremely high-dimensional data linked from multi-centres.MethodsWe collected BC cases and control patients (n = 64,884) linked at patient-level from Welsh nationwide databases, yielding 48,261 features in primary care settings. The …

Multisite Assembly Of Gateway Induced Clones (Magic): A Flexible Cloning Toolbox For Use In Vertebrate Model Systems, William B Gillespie, Yuwen Zhang, Oscar E Ruiz, Juan Cerda, Joshua Ortiz-Guzman, Michelle Sherman, Williamson D Turner, Gabrielle Largoza, Lili E Mosser, Esther Fujimoto, Chi-Bin Chien, Kristen M Kwan, Benjamin R Arenkiel, W Patrick Devine, Joshua D Wythe

Duncan NRI Faculty and Staff Publications

Here, we present MultiSite Assembly of Gateway Induced Clones (MAGIC), which leverages Gateway-based recombinatorial cloning technology for rapid, modular assembly of plasmids to facilitate transgenesis in cells and vertebrate animal models. The MAGIC collection of plasmids spans a range of in vitro and in vivo uses, from tools for optically and chemically tunable gene expression, to simultaneous expression of microRNAs and fluorescent reporters, to a suite of distinct subcellular compartmental fluorescent reporters, to Cre and Dre recombinase-dependent gene expression. MAGIC system components are compatible with existing MultiSite Gateway Tol2 systems currently used in zebrafish and mammalian lentiviral and adenoviral Destination …

Image-Based Meta- And Mega-Analysis (Ibmma): A Unified Framework For Large-Scale, Multi-Site, Neuroimaging Data Analysis, Nick Steele, Ashley A Huggins, Rajendra A Morey, Ahmed Hussain, Courtney Russell, Benjamin Suarez-Jimenez, Elena Pozzi, Hadis Jameei, Lianne Schmaal, Ilya M Veer, Lea Waller, Neda Jahanshad, Sophia I Thomopoulos, Lauren E Salminen, Miranda Olff, Jessie L Frijling, Dick J Veltman, Saskia B J Koch, Laura Nawijn, Mirjam Van Zuiden, Li Wang, Ye Zhu, Gen Li, Dan J Stein, Jonathan Ipser, Yuval Neria, Xi Zhu, Orren Ravid, Sigal Zilcha-Mano, Amit Lazarov, Jennifer S Stevens, Kerry Ressler, Tanja Jovanovic, Sanne J H Van Rooij, Negar Fani, Sven C Mueller, Anna R Hudson, Judith K Daniels, Anika Sierk, Antje Manthey, Henrik Walter, Nic J A Van Der Wee, Steven J A Van Der Werff, Robert R J M Vermeiren, Christian Schmahl, Julia I Herzog, Ivan Rektor, Pavel Říha, Milissa L Kaufman, Lauren A M Lebois, Justin T Baker, Isabelle M Rosso, Elizabeth A Olson, Anthony King, Israel Liberzon, Michael Angstadt, Nicholas D Davenport, Seth G Disner, Scott R Sponheim, Thomas Straube, David Hofmann, Guangming Lu, Rongfeng Qi, Xin Wang, Austin Kunch, Hong Xie, Yann Quidé, Wissam El-Hage, Shmuel Lissek, Hannah Berg, Steven E Bruce, Josh Cisler, Marisa Ross, Ryan J Herringa, Daniel W Grupe, Jack B Nitschke, Richard J Davidson, Christine Larson, Terri A Deroon-Cassini, Carissa W Tomas, Jacklynn M Fitzgerald, Jeremy Elman, Matthew Panizzon, Carol E Franz, Michael J Lyons, William S Kremen, Brandee Feola, Jennifer U Blackford, Bunmi O Olatunji, Geoffrey May, Steven M Nelson, Evan M Gordon, Chadi G Abdallah, Ruth Lanius, Maria Densmore, Jean Théberge, Richard W J Neufeld, Paul M Thompson, Delin Sun

Faculty, Staff and Students Publications

The increasing scale and complexity of neuroimaging datasets aggregated from multiple study sites present substantial analytic challenges, as existing statistical analysis tools struggle to handle missing voxel-data, suffer from limited computational speed and inefficient memory allocation, and are restricted in the types of statistical designs they are able to model. We introduce Image-Based Meta- & Mega-Analysis (IBMMA), a novel software package implemented in R and Python that provides a unified framework for analyzing diverse neuroimaging features, efficiently handles large-scale datasets through parallel processing, offers flexible statistical modeling options, and properly manages missing voxel-data commonly encountered in multi-site studies. IBMMA successfully …

Characterizing The Metabolites Of The Tyrosine-Kinase Inhibitor Pexidartinib In Mouse Feces, Urine, Plasma, And Liver, Xuan Qin, Si Chen, John M Hakenjos, Jian Wang, Lei Guo, Ashish Dogra, Zhaoyong Hu, Kevin R Mackenzie, Feng Li

Faculty, Staff and Students Publications

Pexidartinib (PEX, TURALIO®), a tyrosine kinase inhibitor, is approved for treating tenosynovial giant cell tumor in adults. However, its potential to cause fatal liver injury has prompted the U.S. FDA to issue a black box warning, and the mechanisms underlying its hepatotoxicity remain largely unknown. As biotransformation may contribute to PEX-induced hepatotoxicity, understanding its metabolism is essential. Our previous research indicated that PEX forms reactive metabolites in human and mouse liver microsomes and in human hepatocytes. We investigated PEX metabolism and liver distribution in mice with a focus on metabolite characterization. Our data shows that PEX is mainly excreted into …

Comparing The Effects Of Ect And Intravenous Ketamine In Psychiatric Patients With Major Depressive Episodes, Julia Myerson, Katrina A Rufino, Sanjay J Mathew, Marie Fletcher, Neil Puri, Hyuntaek Oh

Faculty, Staff and Students Publications

Background: Electroconvulsive therapy (ECT) and intravenous (IV) ketamine are treatments used for severe depression and/or treatment-resistant depression (TRD). ECT is considered one of the most effective treatments for severe depression, although there is debate within the field regarding the effectiveness between ECT and IV ketamine in comparable TRD patient groups.

Methods: This retrospective chart review of open-label, nonrandomized treatment from a psychiatric hospital compared the effects of up to three weeks of ECT and IV ketamine in patients with major depressive episodes (MDEs). Our cohort included 146 inpatients and outpatients aged 18 to 74 years old. 94 patients received subanesthetic …

Forecasting Pediatric Emergency Department Arrivals: Evaluating The Role Of Exogenous Variables Using Deep Learning Models, Egbe Etu Etu, Jordan Larot, Kindness Etu, Joshua Emakhu, Sara Masoud, Imokhai Tenebe, Gaojian Huang, Satheesh Gunaga, Joseph Miller

Faculty Research, Scholarly, and Creative Activity

Background Forecasting pediatric emergency department (ED) demand remains a critical challenge in healthcare operations. This study aimed to identify exogenous variables influencing pediatric ED visits and evaluate the performance of different forecasting models. Method Using a retrospective observational design, we analyzed 192,347 pediatric ED visits across nine hospitals in Southeast Michigan between 2017 and 2019. Patient data were aggregated into daily arrival counts and enriched with exogenous variables such as weather, air quality, pollen, calendar, Google search trends, and chief complaints. Feature selection was performed using XGBoost and SHapley Additive exPlanations to identify the most influential predictors. Three forecasting models …

Image-Based Meta- And Mega-Analysis (Ibmma): A Unified Framework For Large-Scale, Multi-Site, Neuroimaging Data Analysis, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

The increasing scale and complexity of neuroimaging datasets aggregated from multiple study sites present substantial analytic challenges, as existing statistical analysis tools struggle to handle missing voxel-data, suffer from limited computational speed and inefficient memory allocation, and are restricted in the types of statistical designs they are able to model. We introduce Image-Based Meta- & Mega-Analysis (IBMMA), a novel software package implemented in R and Python that provides a unified framework for analyzing diverse neuroimaging features, efficiently handles large-scale datasets through parallel processing, offers flexible statistical modeling options, and properly manages missing voxel-data commonly encountered in multi-site studies. IBMMA successfully …

Short- And Mid-Term Outcomes Of The Extravascular Implantable Cardioverter-Defibrillator In Pediatric And Adolescent Patients: A Single-Center Experience., Nikola Dragisic, Emily R. Backes, Lindsey Malloy-Walton, Edo Bedzra, William Gibson, Philip M. Chang

Manuscripts, Articles, Book Chapters and Other Papers

Experience with the Aurora extravascular (EV) implantable cardioverter-defibrillator (ICD) (Medtronic, Minneapolis, MN, USA) remains limited among pediatric centers in contrast to its broader implantation in adults. We evaluated our single-center experience with the EV ICD as part of our standard ICD options for treatment of malignant ventricular arrhythmias in pediatric subjects. Following approval for EV ICD implantation at our center, five consecutive adolescent patients underwent implantation over a 7-month period. Patient characteristics, qualification for EV ICD placement, nuances in EV ICD implantation in each patient, and post-implant follow-up were reviewed. A total of six out of eight consecutive ICD candidates …

Evaluation Of The Impact Of Coriander Sativum Extract On The Modulation Of Inflammatory And Oxidative Enzymes In Ptz Induced Epilepsy In A Rat Model, Rusul Ali Kadhim, Zahraa Saleem Manji

Maaen Journal for Medical Sciences

Background

Recurrent and spontaneous seizures are a symptom of the epilepsy. It affects up to 65 million individuals globally, with lower-income nations accounting for 80% of cases. Since medicinal plants have special therapeutic qualities, they are frequently used to manage and cure epilepsy and convulsions. Because they have fewer side effects and stronger therapeutic results, medicinal plants are becoming more and more popular worldwide as a result of increased research and clinical use. The pharmaceutical industry is now concentrating heavily on the creation of novel plant-based antiepileptic/anticonvulsant drugs

Aims of the study:

Study the role of coriander sativum extraction in …

Torts And Pesticide Drift: Amending Right-To-Farm Acts In The Wake Of Widespread Dicamba Drift By Nicholas Brown** And Matt Roessing*

Journal of Legal Studies in Business

When crops die in a field prior to harvest, a farmer loses a portion of his salary for that year. When the cause of the crop loss is natural, farmers can usually seek compensation through crop insurance and government commodity support programs. When the crops were lost as a result of pesticide drift, these forms of compensation are not usually available to farmers.1 In order to make up for their losses, farmers can seek damages through judicial redress. For many decades, various state and federal laws have combined to complicate and at times prevent farmers adversely affected by pesticide drift …

Cover Page & Table Of Contents - Volume 23

Journal of Legal Studies in Business

JLSB vol. 23 Title Page & Table of Contents

Latine Doctoral Student Experiences In U.S. Counselor Education And Supervision Programs, Nayara Aparecida Da Costa Silva Beall, Lizbeth Duran Oden, Isabel C. Farrell, Mariaimeé Gonzalez, Stephanie Thorson-Olesen

Journal of Counselor Preparation and Supervision

This study explored the experiences of Latine doctoral students in Counselor Education and Supervision programs in the United States. The consensual qualitative research yielded five domains: cultural values, representation, racialized experiences, support, and social justice. The findings are discussed with direct applications for programs and recommendations for future research.

Evaluating Competencies In Counseling Students: Comparing Adjunct And Core Faculty Ratings, Mark D. Newmeyer, Kaitlyn C. Stafford, Peter J. Buckingham, Karen E. Fischer, Meredith D. Mcdaniel, Rhys P. Wilson

Journal of Counselor Preparation and Supervision

This study examines the differences in how adjunct and core faculty evaluate counseling students using a brief version of the Counselor Competencies Scale-Revised (CCS-R). Data from 647 evaluations of 433 students were analyzed. The results show that adjunct faculty, particularly those with master's degrees, tend to rate students significantly higher on professional counseling dispositions than core faculty, raising concerns about the consistency of gatekeeping in counselor training programs. These findings suggest a need for the standardization of counseling disposition evaluation practices to maintain high training standards. Implications for student-to-faculty ratio requirements are discussed.

Counselor Education: Digital Delivery With Confidence, Nicole Marie Arcuri-Sanders, Alisha Davis

Journal of Counselor Preparation and Supervision

Counselor education programs are required to demonstrate a clear framework, effective implementation, and overall program effectiveness. The pandemic’s surge in online instruction influenced CACREP’s (2024) digital delivery (DD) standards, addressing ethical and legal implications alongside student outcomes. Guidance from digital health initiatives, telemental health ethics and legal practices can be invaluable in clarifying DD protocols for counselor education programs. Understanding the parallels between DD and digital health regulations (e.g., HIPAA, ACA [2014], and NBCC [2023] ethical codes) provides a solid foundation for protecting both students and programs. Integrating technology and modeling digital health practices can enhance counselor education, benefiting both …

Training School Counselors In Anti-Racist Practices, Yenitza Z. Guzman, Tj Schoonover, Christy Tran

Journal of Counselor Preparation and Supervision

This study examines the lived experiences of school counselors-in-training and their development as anti-racist school counselors. Using a qualitative phenomenological approach, we conducted in-depth interviews with 17 school counselors-in-training with a focus on their development and training as anti-racist practitioners. The findings of the study included four themes: (a) education, (b) experiential learning, (c) suggestions for improvement, and (d) cultural competency. This article indicates implications for school counselor educators and school counselors-in-training.

A Holographic Approach: Counseling Skill Development At The Doctoral Level, Kelly Coker, Kristi Cannon, Robyn T. Simmons, Anjuli Corzine

Journal of Counselor Preparation and Supervision

This study examines the perceptions and attitudes of a six-person focus group of counselor educators about teaching advanced counseling skills in CACREP accredited Counselor Education and Supervision doctoral programs. Results of the framework analysis indicate that while counseling skills are valued at the doctoral level, there is a need for individualized and collaborative construction of both assessments for and activities within doctoral internships in counseling. A Holographic Model of Doctoral Skills Training is introduced, providing a comprehensive framework for enhancing doctoral-level counseling skills training in counselor education and supervision programs.

Practicing With Avatars: Exploring Mixed Reality Simulation To Develop Msjccs, Amy L. Cook, Lillian Day, Kristin M. Murphy, Taylor Healy, Julia Kausel, Lindsay M. Fallon, Christopher B. Denning

Journal of Counselor Preparation and Supervision

This study used qualitative content analysis (QCA) to explore perceptions of engaging in Mixed Reality Simulation (MRS) with avatars on the development of Multicultural and Social Justice Counseling Competencies (MSJCCs) for school counselors in training. Results suggested that MRS contributed to improving participants’ confidence in MSJCCs, and they would have valued additional practice with MRS to address implicit bias with clients. Results indicate the need for additional MRS research to advance the development of MSJCCs in school counselor training.

Mental Health Concerns Counselors Should Be Aware Of When Working With Women Experiencing Infertility, Corrina Harris, Kellie Forziat-Pytel

Journal of Counselor Preparation and Supervision

Women experiencing infertility (WEI) are a unique group that rarely receives acknowledgment in the literature as such. These women encounter physical, emotional, and financial burdens throughout their infertility journey. Counseling research is limited on information addressing the experiences of WEI. This article highlights this unique group by providing an overview of the infertility journey for women. Counselors will learn the common mental health concerns to be aware of when working with WEI and examine a case example of infertility with a counselor’s approach. In addition, the article will identify the research gaps related to this population. Implications are made for …

Life Balance For Counselors-In-Training: An Interpretative Phenomenological Investigation, Corey Olver

Journal of Counselor Preparation and Supervision

Life balance is an important yet understudied construct for counselors-in-training (CITs). Pursuing a graduate degree in counseling involves an investment of time and resources that may increase stress and adversely affect CIT wellbeing. This study explores the experience of ten CITs as they navigated life balance during their education. Analysis revealed that life balance was challenging as CITs managed their educational, personal, and work demands. Key findings reveal that satisfaction with life balance is related to alignment between real and ideal activity engagement, that students made important sacrifices to maintain balance, and their educational experience contributed to life balance perception. …

Incorporating Tax Law Into Legal And Regulatory Environment Of Business Courses

Journal of Legal Studies in Business

No abstract provided.

Too Much, Too Little, Or Just Right? Beyond The Perception (Or Reality) Of Law School Rigor In Teaching Undergraduate Copyright Law

Journal of Legal Studies in Business

No abstract provided.

In Vivo Pharmacokinetic Evaluation Of A Gastro-Retentive Triple Drug Delivery System Utilizing Natural Polymers For Enhanced Helicobacter Pylori Eradication, Edukulla Satheesh Kumar, Hindustan Abdul Ahad, Thirumalesh Naik Sugali Banoth

Bulletin of Faculty of Pharmacy Cairo University

This study evaluates the in vivo pharmacokinetics of triple-drug gastro-retentive formulation (metronidazole- Plantago ovata seed mucilage/ clarithromycin- Abelmoschus esculentus fruit mucilage/enteric-coated pantoprazole) for Helicobacter pylori eradication, with a focus on pharmacokinetic parameters (e.g., relative bioavailability vs. conventional doses) as the true contribution. In a cross over study using six rabbits, plasma concentrations of metronidazole, clarithromycin, and pantoprazole sodium were measured via High Performance Liquid Chromatography technique, and pharmacokinetic parameters were determined. A single dose of the optimized formulation (C-8) produced optimal drug levels, with a mean Cmax of 24.36 ± 0.84 μg/mL and tmax at 6 hours. The other pharmacokinetic …