Digital Commons Network^™

Social Well-Being Moderates Behavioral Therapy Response For Generalized Anxiety Disorder., Jacob D. Armstrong, Nicole R. Baughman, Ricardo A. Wilhelm, Dalia El-Shafie, Hannah Berg, Hung-Wen Yeh, Elisabeth Akeman, Christopher Martell, Kate B. Wolitzky-Taylor, Michelle G. Craske, Martin P. Paulus, Robin Aupperle

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Identifying moderators of treatment outcome for depression and anxiety offers promise for personalizing treatment or providing novel intervention targets. Indices of social well-being have emerged as candidate moderators due to their robust impact on mental health and quality of life. Here, we examine whether measures of social support, isolation, and loneliness moderate outcomes to behavioral activation (BA) and exposure-based therapy (EXP) for individuals with GAD.

METHODS: This secondary analysis of a randomized clinical trial included 69 participants (31 EXP, 38 BA). Participants completed the GAD-7, along with NIH PROMIS (Depression; Social Isolation; and Emotional, Instrumental, and Informational Support) and …

Left And Right Ventricular Strain Mechanics In Fetal Tachyarrhythmia., Rukmini Komarlu, Janelle R. Noel-Macdonnell Phd, Neha Chellu, Geetha Haligheri

Manuscripts, Articles, Book Chapters and Other Papers

Introduction: Assessment of myocardial function in fetuses with supraventricular tachyarrhythmia is challenging. Speckle-tracking echocardiography (STE) is a newer sensitive method to assess ventricular systolic function. We sought to assess left (LV) and right (RV) ventricular myocardial strain mechanics in fetuses with tachyarrhythmia and hypothesized that strain mechanics are impaired in this patient population even after conversion to sinus rhythm.

METHODS: This was a single-center retrospective review. LV and RV strain parameters were assessed using STE in tachyarrhythmia and after conversion to sinus rhythm and, compared to gestational age (GA), matched control fetuses in sinus rhythm.

RESULTS: Eighteen fetuses with tachyarrhythmia …

Clinical Pharmacogenetics Implementation Consortium Guideline For Nat2 Genotype And Hydralazine Therapy., Michael T. Eadon, David W. Hein, Michael A. Andersen, Arlene B. Chapman, Rhonda M. Cooper-Dehoff, Zeruesenay Desta, Julio D. Duarte, Amanda L. Elchynski, Andrea Gaedigk, Seth E. Karol, Nita A. Limdi, Christelle Lteif, Laura Sosinski, Pablo Zubiaur, Michelle Whirl-Carrillo, Teri E. Klein, Kelly E. Caudle, Roseann S. Donnelly, José A G Agúndez

Manuscripts, Articles, Book Chapters and Other Papers

Hydralazine is a vasodilator typically used in the treatment of resistant hypertension and heart failure. N-acetyltransferase 2 (NAT2) catalyzes the metabolism of hydralazine into inactive metabolites. NAT2 poor metabolizers (historically referred to as "slow acetylators") are predicted to have increased plasma hydralazine concentrations compared with NAT2 rapid and intermediate metabolizers (historically referred to as "rapid acetylators" and "intermediate acetylators," respectively), which may lead to both increased clinical efficacy and adverse effects, including drug-induced systemic lupus erythematosus. This guideline summarizes the evidence from the literature relevant to NAT2/hydralazine and provides recommendations for hydralazine prescribing based on NAT2 genotype-predicted acetylator phenotype (updates …

Adenovirus Types In Us Children Hospitalized Or Seen In The Emergency Department With Acute Respiratory Illness, 2016-2019., Tess Stopczynski, Varvara Probst, Adam Gailani, Justin Z. Amarin, Olla Hamdan, Haya Hayek, Laura S. Stewart, Herdi K. Rahman, Rangaraj Selvarangan, Jennifer E. Schuster, Christopher J. Harrison, Mary E. Moffatt, Marian G. Michaels, John V. Williams, Julie A. Boom, Leila C. Sahni, Vasanthi Avadhanula, Mary Allen Staat, Elizabeth P. Schlaudecker, Christina Quigley, Geoffrey A. Weinberg, Peter G. Szilagyi, Janet A. Englund, Eileen J. Klein, Aaron T. Curns, Heidi L. Moline, Ariana P. Toepfer, James D. Chappell, Andrew J. Spieker, Natasha B. Halasa

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Human adenovirus (HAdV) is a common cause of pediatric acute respiratory illness (ARI), contributing to 5-13% of cases worldwide. Clinical manifestations vary by HAdV species and type; therefore, delineating type-specific disease presentations and understanding severity of specific HAdV types' disease may help develop targeted interventions.

METHODS: We conducted a multicenter, prospective study within the New Vaccine Surveillance Network to characterize HAdV types. Children < 18 years old with ARI were enrolled in the emergency department or inpatient setting at 7 US children's hospitals from 1 December 2016 to 30 November 2019. Respiratory specimens were collected and tested for HAdV and other viruses. Subsequently, typing was conducted on HAdV specimens using single-plex real-time PCR assays targeting sequences in the hexon gene. Comparisons between HAdV types were performed to determine differences in characteristics and outcomes. Generalized linear mixed effects models were used to evaluate severity.

RESULTS: Among the 1843 HAdV-positive cases, 1402 specimens (76%) were typed. The most common types detected were HAdV-C1 (n = 439), HAdV-C2 (n = 393), and HAdV-B3 (n = 221). Children with HAdV-B7 (n = 78) …

The Effect Of Shared Decisions On Intertemporal Choice, Rosemarie M. Davidson

Masters Theses

Substance use disorders are a significant public health concern, and improving treatment outcomes requires a better understanding of the behavioral processes that influence drug consumption. Delay discounting, or the tendency to overvalue immediate reinforcers, is reliably more severe among individuals with substance use disorders. Recent work suggests that shared decision-making may increase tolerance for delayed rewards; however, prior studies used procedures that confounded delay to token delivery with delay to token exchange, limiting conclusions. The present study evaluates delay discounting across individual and social decision-making contexts using a traditional delay discounting paradigm.

Ten undergraduate participants completed sessions involving choices between …

Elevated Serum Bile Acids Predict Poor Liver Outcomes In Children With Alagille Syndrome: Results From The Gala Study Group., Carla Fiorella Murillo Perez, Shannon M. Vandriel, Emmanuel M. Gonzales, Jian-She Wang, Li-Ting Li, Huiyu She, Irena Jankowska, Piotr Czubkowski, Dorota Gliwicz-Miedzińska, Emmanuel Jacquemin, Jérôme Bouligand, Lorenzo D'Antiga, Emanuele Nicastro, Björn Fischler, Henrik Arnell, Susan M. Siew, Michael Stormon, Kathleen M. Loomes, David A. Piccoli, Elizabeth B. Rand, James E. Squires, Saul J. Karpen, Rene Romero, Mureo Kasahara, Zerrin Önal, Étienne Sokal, Tanguy Demaret, Sabina Wiecek, Florence Lacaille, Dominique Debray, Winita Hardikar, Sahana Shankar, Pamela L. Valentino, Shikha S. Sundaram, Noelle H. Ebel, Jeffrey A. Feinstein, Orith Waisbourd-Zinman, Henry C. Lin, Nathalie Rock, Henkjan J. Verkade, M Kyle Jensen, Catalina Jaramillo, Kyung Mo Kim, Seak Hee Oh, Jernej Brecemiclj, Seema Alam, Giuseppe Indolfi, Niviann Blondet, Rima Fawaz, Silvia Nastasio, Pier Luigi Calvo, Gabriella Nebbia, Cigdem Arikan, Catherine Larson-Nath, Andréanne N. Zizzo, Thomas Damgaard Sandahl, Christos Tzivinikos, Nehal M. El-Koofy, Mohamed A. Elmonem, Amal A. Aqul, Wikrom Karnsakul, Pinar Bulut, Nanda Kerkar, Victorien M. Wolters, Amin J. Roberts, Helen M. Evans, Maria Camila Sanchez, Maria Lorena Cavalieri, Deirdre A. Kelly, Jane Hartley, Way Seah Lee, Christina Hajinicolaou, Chatmanee Lertudomphonwanit, Ryan T. Fischer, Jesus Quintero Bernabeu, Ruben E. Quiros-Tejeira, Cristina Targa Ferreira, Elisa Carvalho, John Eshun, Aglaia Zellos, Antal Dezsőfi, Raquel Borges Pinto, Kathleen Schwarz, Maria Rogalidou, Jennifer Garcia, María Legarda Tamara, Marisa Beretta, Quais Mujawar, Ermelinda Santos-Silva, Cristina Molera Busoms, Eberhard Lurz, Cristina Gonçalves, Carolina Jimenez-Rivera, Jesus M. Banales, Richard J. Thompson, Bettina E. Hansen, Binita M. Kamath, Global Alagille Alliance (Gala) Study Group

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND AND AIM: Alagille syndrome (ALGS) is a rare disorder characterised by cholestasis and extrahepatic manifestations. Given the current era of ileal bile acid transporter (IBAT) inhibitor therapies that reduce serum bile acid (SBA) levels, we evaluated whether SBA predicts liver disease outcomes in ALGS.

METHODS: Patients were ascertained from the Global ALagille Alliance (GALA) cohort. A prognostic threshold of SBA 102 μmol/L was assessed as a time-dependent covariate in Cox regression analyses for native liver survival (NLS) and event-free survival (EFS), while adjusting for total bilirubin (TB) levels.

RESULTS: 570 GALA patients were included (348 [61%] male). There was …

Clinical Long-Read Sequencing Test For Genetic Disease Diagnosis., Isabelle Thiffault, Emily G. Farrow, Cassandra Barrett, Meadow Scott, Amy Ross, John C. Means, Warren A. Cheung, Adam F. Johnson, Boryana Koseva, Rebecca Mclennan, Elin Grundberg, Chengpeng Bi, Carl F. Schreck, Byunggil Yoo, Jeffrey J. Johnston, Florencia Del Viso, Vitoria Paolillo, John Herriges, Lei Zhang, Margaret Gibson, Ana S A Cohen, Joseph Alaimo, Carol J. Saunders, Tomi Pastinen

Manuscripts, Articles, Book Chapters and Other Papers

This diagnostic study examines the diagnostic yield and turnaround time of long-read sequencing compared to standard-of-care approaches.

Halo Gravity Traction And Temporary Internal Distraction, Nicholas D. Fletcher, Anson G. Bautista, Joshua S. Murphy, K Aaron Shaw

Manuscripts, Articles, Book Chapters and Other Papers

Severe pediatric spinal deformities may require staged correction strategies to mitigate neurologic risk and optimize cardiopulmonary outcomes. This paper reviews two adjunctive techniques—halo gravity traction (HGT) and temporary internal distraction (TID)—used in the management of rigid scoliosis. HGT enables gradual preoperative spinal elongation and coronal/sagittal realignment, improving pulmonary function and nutritional status while reducing the need for three-column osteotomies. TID offers an internal, staged distraction approach for patients contraindicated for external traction, allowing incremental correction via posterior instrumentation followed by definitive fusion. Clinical studies report Cobb angle reductions of 30–80 %, with low rates of neurologic complications when neuromonitoring and …

Overview Of Huntington's Disease And Emerging Treatment Strategies: A Narrative Review, Alexis J. Vega, Gabriel V. Hernandez, Pearse A. O'Malley, Connor J. Robin, Amanda N. Parra, Giustino Varrassi, Sahar Shekoohi, Alan D. Kaye

School of Medicine Faculty Publications

Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disorder caused by a cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin (HTT) gene. The symptoms of HD include severe motor dysfunction, cognitive issues, and emotional dysregulation. These combined issues are not only debilitating but also lead to depression/anxiety, increased suicide rates, and caregiver burnout. Our narrative review summarizes several recent studies examining the efficacy and differences among emerging treatment strategies for HD. A systematic search of peer-reviewed literature was conducted, focusing on recent studies that describe molecular genetic manipulation of the HTT gene/huntingtin protein. The results of our narrative review reveal …

Effective Transfer Of Tumor Annotations From Hematoxylin And Eosin To Fluorescence Images Of Breast And Lung Tissues, Tianling Niu, Emi Ampo, Julie M. Jorns, Mollie Patton, Tongtong Lu, Dong Hye Ye, Tina Yen, Bing Yu

Biomedical Engineering Faculty Research and Publications

Significance: Accurate transfer of annotations from histological images to fluorescence images is essential in developing deep learning (DL)-based optical imaging systems for intraoperative assessment of tumor margins. Manual annotation is time-consuming, prone to interobserver variability, and impractical for large-scale datasets.

Aim: We present a semi-automated method that can effectively transfer tumor annotations from pathologist-annotated hematoxylin and eosin (H&E) images to fluorescence images captured using microscopy with ultraviolet surface excitation (MUSE). This method is not intended for intraoperative use but rather to facilitate the creation of annotated datasets for DL model development.

Approach: Our semi-automated method consists of nonrigid image registration, …

Schema, Stigma, And The “We-Them” Divide: Perspectives On Ageism From Everyday Life To Healthcare, Temple D. West

English Theses & Dissertations

Ageism remains a pervasive and often underexamined form of discrimination, affecting older adults across both everyday and clinical contexts. This paper explores how cognitive schemas—mental frameworks that shape perception and experience—and stigma interact to reinforce a “we–them” divide between and older patients and healthcare providers, as well as between older and younger individuals in broader society. Through focus groups and listening to the voices of older patients, this study examines how assumptions of age-based decline are embedded in society and inform schemas of ageism. It considers how those schemas shape the spoiled identity of older people as a stigmatized group, …

When Nonbinary Becomes Binary: Exploring Transnormativity Experiences Of Gender Diverse Individuals, Yusuf Barburoğlu

Counseling & Human Services Theses & Dissertations

Transnormativity is a within-group framework that positions trans and nonbinary (TNB) individuals in a hierarchy of legitimacy based on adherence to binary gender norms (Johnson, 2016). Nonbinary individuals, who comprise 38% of U.S. transgender adults, face unique challenges, including systemic invalidation, misgendering, and erasure both within and outside LGBTQIA+ communities (James et al., 2024; Matsuno et al., 2024). These experiences intersect with internalized stigma and rejection expectations, contributing to mental health disparities (Budge et al., 2014; Lefevor et al., 2019). This study explores how nonbinary individuals navigate, resist, and embody transnormative pressures, using Sarah Ahmed’s Queer Phenomenology and Interpretative Phenomenological …

Examining The Perceptions Of Economics And Personal Finance Teachers' Preparedness To Teach Financial Literacy, Tasha L. Wearren

Educational Leadership & Workforce Development Theses & Dissertations

Financial literacy has become an important topic in our society. Despite an increased focus in financial literacy education, there is limited research assessing teachers’ ability to teach financial literacy by examining their endorsement area. According to Soroko (2021), research is limited regarding teachers’ beliefs and practices as it relates to financial literacy. As O’Neill and Hensley (2016) indicated, “Teachers cannot teach personal finance well if they do not understand it themselves and/or cannot engage their students” (p. 639). This qualitative multiple case study examined how Economics and Personal Finance teachers perceive their preparedness to teach financial literacy with different endorsements. …

Examining Social And Intrapersonal Factors Among Youth Crisis Line Volunteers, Sunday Hull

Psychology Theses & Dissertations

Crisis lines provide a free crisis response service that is highly accessible to individuals who are at elevated risk of suicide and may not be otherwise connected with care. In order to best tailor crisis line interventions to youth populations, a number of youth-to-youth crisis lines invite youth callers to connect with trained youth volunteers. While prior research has examined adult crisis lines workers’ experience and well-being and identified key factors that predict positive and negative volunteering outcomes, far less is known about similar determinants of experience and well-being among adolescent volunteers on youth-to-youth crisis lines. The purpose of this …

Exploring The Microbiomes Of Camel Ticks To Infer Vector Competence: Insights From Tissue-Level Symbiont-Pathogen Relationships, Rua Khogali, Armanda Bastos, Dennis Getange, Joel L. Bargul, Shewit Kalayou, Nehemiah Ongeso, Joost Theo Petra Verhoeven, James Kabii, John Ngiela, Daniel Masiga, Jandouwe Villinger

All Peer-Reviewed Publications

Ticks are blood-feeding ectoparasites that harbor diverse pathogens and endosymbionts. Their microbial communities vary based on tick species, stage, sex, geographical location, surrounding environment, and tissue type. Understanding tick microbiota at the tissue level is crucial for unraveling how microbiomes are distributed in tick tissues and influence pathogen transmission. We used V1-V2 16 S rRNA gene sequencing to analyze tissue-specific bacterial compositions (hemolymph, saliva, salivary glands, and midgut) of Amblyomma gemma, Rhipicephalus pulchellus, Hyalomma dromedarii, and Hyalomma rufipes ticks collected from camels in Marsabit County, northern Kenya. The V1-V2 region of the 16 S rRNA gene effectively differentiated 43 Rickettsia …

The Lived Experiences Of Black Female Leaders At An Hbcu Whose Predecessors Are Non-Black Females, Patricia Pearsall Williams

All Dissertations

This study used a rigorous qualitative hermeneutic phenomenological approach to examine the lived experiences of eight Black female leaders at Historically Black Colleges and Universities (HBCUs) in one of the following geographic regions in the United States: the South Atlantic, Eastern South Central, and West South Central (U.S. Census Bureau, 2022). The leadership roles for this study included, but were not limited to, president, senior vice president, assistant provost, vice president, dean, executive director, director, assistant director, associate director, department head, manager, or supervisor.

By examining the essences, nuances, and differences of these experiences, the researcher aimed to understand how …

The Role Of Administrative Leadership And Strategic Management In Improving The Responsiveness Of Health Systems To Pandemics: An Analysis Of The Covid-19 Pandemic Experience, Naseem Abdulghaffar Saeed Bazuhair

University of Tabuk Journal for Humanities and Social Sciences

This study aims to understand the role of strategic administrative leadership in responding to the COVID-19 pandemic, focusing on the health policies and strategic planning adopted by health systems to ensure the continuity of medical services and adapt to the rapid changes of the pandemic. The research addresses key strategies such as establishing emergency centres, coordinating between hospitals, developing standardized care and isolation protocols, and ensuring the availability of medical supplies and vaccines. It also emphasizes practices for maintaining the continuity of health services, including separating COVID-19 departments from other services, enhancing the use of digital solutions and telemedicine, and …

Presenteeism Among Health Care Personnel With Covid-19, James C. Crosby, Eliezer Santos Leon, Brian Chinnock, Karisa K. Harland, Anusha Krishnadasan, Nicholas M. Mohr, Ian D. Plumb, Melissa Briggs Hagen, Kelli Wallace, David A. Talan, Anne Zepeski, Tracy Young, Howard A. Smithline, Lilly C. Lee, Stephen C. Lim, Gregory J. Moran, Mark T. Steele, David G. Beiser, John P. Haran, Peter C. Hou, Brett Faine, Utsav Nandi, Walter A. Schrading, Anne Chipman, Frank Lovecchio, Alysia Powers, Lisandra Uribe, Kavitha Pathmarajah, Dean M. Hashimoto, Chloe Namias, Efrat Kean, Elizabeth Krebs, Amy Stubbs, Sara Roy, Lucia Solis, Mary Mulrow, Nathan Graff, Jillian M Tozloski, William Mower, Jacqueline Caldera, Michelle Huber, Jacob Hampton, Abigail Lopes, Katherine Elkort, Stephanie A. Eucker, Carla Kingsbury, Jonathan Femling, Silas Bussmann, Jane Yee, Joseph Stuppy, Richard E. Rothman, Gaby Dashler, Marcel E. Curlin, Mastura Wahedi, Laurie Kemble

Department of Medicine Faculty Papers

IMPORTANCE: Presenteeism-defined as continuing to work during an illness-poses a public health risk in the workplace and is especially hazardous within health care institutions where vulnerable patients may be exposed to nosocomial infections. Understanding the frequency and characteristics of health care personnel (HCP) who report presenteeism while ill with COVID-19 may help mitigate SARS-CoV-2 spread in hospitals and other health care institutions.

OBJECTIVES: To determine the frequency of presenteeism among HCP with symptomatic COVID-19, and to evaluate the demographic, occupational, and clinical factors associated with it.

DESIGN, SETTING, AND PARTICIPANTS: This is an observational cohort study that uses data from …

Physics-Guided Strategies For Enhancing Neural Networks Trained With Limited Data, Jose Guadalupe Perez Zamora

Open Access Theses & Dissertations

Deep neural networks excel at a wide range of processing tasks across various disciplines. However, the quantity and quality of data significantly impact network performance. In specialized domains, high-quality datasets are often difficult to gather, interpret, and curate for effective learning. Few-shot learning techniques, including transfer learning, data augmentation, and meta-learning, have emerged to address these constraints.

We propose three physics-guided strategies for enhancing neural networks trained with limited data: (1) combining existing models like LSTMs with Physics-Informed Neural Networks through two-branch architectures that merge their outputs, (2) deriving custom physics-informed data augmentation algorithms to expand limited datasets, and (3) …

De Novo Genome Assembly, Annotation, And Characterization Of Chemosensory Genes In The Camel Ked (Hippobosca Camelina), Fredrick Kebaso, Souleymane Diallo, Caleb Kibet, Suhaila Hashim, John Mark O. Makwatta, Merid Getahun, Dennis Getange, Jean Baka Domelevo Entfellner, Daniel Masiga

All Peer-Reviewed Publications

Background: Hippobosca camelina (camel ked) is an obligate hematophagous ectoparasite that infests camels. Hematophagy inflicts painful bites leading to myiasis, anemia and pathogen transmission such as Candidatus Anaplasma camelii. A genome assembly for this biting flies is currently unavailable, limiting understanding of its genetics, including the chemosensory system.

Results: The assembly size for Hippobosca camelina female is 135.6 Mb with 17.08% repeated regions, an N50 of 1.2 Mb, a total of 2,182 contigs, a GC content of 33.5% and compleasm (Busco) completeness of 95.38% with the diptera_odb10 lineage (S:95.83%, 3148, D:0.30%, 10, F:0.30%, 10, I:0.00%, 0, M:3.56%, 117, N:3285) …

Pretreatment Methods For Organic Waste Management As Feed For Black Soldier Fly, Mube K. Hervé, Gatchueng F. Lionel, Ndomou C.H. Serge, Dzepe Daniel, Shaphan Y. Chia, Kana Jean Raphael, Kenfack Augustave, Djouaka Rousseau, Sali A. Ndindeng

All Peer-Reviewed Publications

Amidst escalating global urbanization and population growth, revolutionizing food systems and redefining waste management strategies has become essential. This study contributes to protein resource diversification in animal feed and offers a sustainable solution for organic waste management using black soldier fly larvae (BSFL) in Bafia, Cameroon. A survey characterized waste production in restaurants and households to assess quantity and quality. Collected organic wastes underwent two pre-treatments: heating, (60°C) and fermentation (4 days), while another batch was used fresh as a feeding substrate for BSFL, in contrast to a broiler starter diet over a 17-day larval feeding experimental period. Various parameters …

Opportunities For Expansion Of Push-Pull Technology As An Agroecological And Sustainable Intensification Approach In Africa, Gudeta W. Sileshi, Shem Kuyah, Meredith C. Schuman, Frank Chidawanyika, Beatrice W. Muriithi, Charles A.O. Midega, Adewole Olagoke, Michael H. Otim, Paramu L. Mafongoya, Emily A. Martin

All Peer-Reviewed Publications

The push-pull technology (PPT) has often been presented as a management strategy for stemborers and witchweed. However, its value as an agronomic practice and an agroecological approach remains largely underappreciated. This review aims to appraise the PPT used in eastern Africa, synthesize evidence for its ecological and economic benefits, and identify barriers to its adoption and opportunities for its expansion to other crops and farming systems in sub-Saharan Africa.

Endoscopic Retrograde Cholangiopancreatography And Primary Sclerosing Cholangitis: A Retrospective Study Of A High-Volume Program, Kristel Leung, Michael Youssef, Yasi Xiao, Catherine Streutker, Aliya Gulamhusein, Bettina Hansen, Natalia Calo, Gary May, Jeffrey Mosko, Gideon Hirschfield

Division of Gastroenterology and Hepatology Faculty Papers

BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) is valuable in management of primary sclerosing cholangitis (PSC). Herein, we characterize individuals with PSC who underwent ERCP on-demand at a high-volume quaternary centre, with evaluation of pathology results and short-term postprocedural outcomes.

METHODS: This retrospective cohort study evaluated patients with PSC who underwent ERCP at St Michael's Hospital between April 2011 and July 2021. Chart review was conducted to collect clinical, procedural, and pathology data, and reported post-ERCP complications within 90 days. Logistic regression analyses were conducted to evaluate factors associated with post-ERCP complications and placement of a biliary stent.

RESULTS: One hundred and …

Advancing Trypanosoma Cruzi N-Myristoyltransferase As A Drug Target For Chagas Disease Through In Silico Discovery And Biochemical Evaluation, Diana Citlali González García

Open Access Theses & Dissertations

Chagas disease remains one of the most persistent and neglected parasitic infections in the Americas, advancing silently through the intracellular replication of Trypanosoma cruzi amastigotes and the invasive spread of trypomastigotes. The survival of the parasite is critically reliant on protein N-myristoylation, a lipid modification catalyzed by N-myristoyltransferase (NMT). This dissertation aims to advance beyond prior studies by systematically investigating NMT inhibition across multiple biological levels, spanning from the characterization of the purified enzyme, through cellular infection models, to the global proteomic remodeling induced within the parasite, thereby evaluating TcNMT as a potential therapeutic vulnerability in T.cruzi.Recombinant TcNMT was expressed, …

Calibration Of Low-Cost Pm2.5 Sensors Using Data Continuously Generated At A Reference Station In El Paso, Texas, Brenda Lizbeth Hernandez

Open Access Theses & Dissertations

Low-cost sensors (LCS) offer a cost-effective way to expand air-quality monitoring networks, but they require strong calibration methods to ensure reliable performance under changing environmental conditions. In this study, Clarity LCSs were co-located with a state reference monitor for 6 months to evaluate fixed-time (2-, 3-, 4-, and 6-week) and rolling (2- and 3-week) calibration approaches. A multivariate regression model using PM1, PM2.5, PM10, and relative humidity was used to generate calibration coefficients for a “base sensor.” Data from two additional sensors were normalized to the base unit using linear regression, and their calibration coefficients were applied across the network. …

Our Trajectories As We Leave The Teaching Profession: Pláticas With Former Bilingual Teachers On The U.S.-Mexico Border In Texas- An Explanatory Sequential Mixed-Methods Study, Carla Medina Jaquez

Open Access Theses & Dissertations

Teacher attrition has had a negative impact on the educational system for many years. New and experienced teachers have been leaving the classroom. Although the reasons appear repetitive, we know relatively little about what teachers must go through when deciding to leave the profession and what happens to them afterward. A teacher shortage is occurring along the U.S.-Mexico border, as in many other cities across the United States. Despite undergoing a lengthy certification process, teachers continue to leave the classroom. This research employed an explanatory sequential mixed-methods design to explore how new and experienced teachers navigate their transition out of …

Exploring Intergenerational Conflicts Association Among Cultural Values, Bicultural Identity Integration, And Alcohol Use Severity Within Hispanic College Student Drinkers, Ashley Marie Lindquist

Open Access Theses & Dissertations

Hispanic college students are at higher risk of experiencing family conflict [i.e., intergenerational conflict (IGC)] and engaging in increased alcohol use as they begin adopting values aligned with higher education institutions. Furthermore, minoritized students often develop an additional cultural identity influenced by mainstream values, resulting in a form of biculturalism. Research has sought to understand the navigation of values and identity through the concept of Bicultural Identity Integration (BII). However, limited research has examined the effects of BII on cultural values, IGC, and subsequent alcohol use among Hispanic college students. The current study explored the direct and indirect effects of …

Exploring Intersectional Risks Of Substance Use Disorder, Mental Health, Hiv/Aids, And Hepatitis C Among Hispanic Adults On The Tx-Mx Border: A Mixed-Methods Study, Md Mohsin

Open Access Theses & Dissertations

Purpose: The purpose of this study was to explore intersectional risks of substance use disorders, mental health, HIV/AIDS, and HCV among Mexican-origin Hispanic adults on the Texas-Mexico border. Methods: The study employed an exploratory sequential mixed-methods approach, which involved collecting and analyzing qualitative data first, followed by quantitative data collection. Selected purposively, 15 in-depth interviews were conducted among the target population. Using convenient sampling, 106 cross-sectional surveys were conducted. Qualitative interview data were analyzed manually using thematic analysis. Quantitative data analyses included univariate descriptive analysis, bivariate, and multivariable penalized logistic regression, negative binomial, and zero-inflated negative binomial regression. Results: The …

Further Insights Into The Network Link Outlier Factor's (Nlof) Light-Load Penalty, Sunday Oluwaleke Ogundele

Open Access Theses & Dissertations

This research investigates the performance of the Network Link Outlier Factor with Most Likely Links (NLOF:MLL), under varying network load conditions. Earlier studies reported that the NLOF:MLL algorithm experienced a noticeable drop in fault-localization accuracy when operating in lightly loaded networks. To further examine this limitation, 240 experiments were carried out to observe how the algorithm responds as overall network load increases. The evaluation focused on the classification performance metrics: precision, recall, and F1-score. The results show that NLOF:MLL’s effectiveness improves as network load increases but that the rate of improvement slows progressively, eventually stabilizing in a pattern consistent with …

Decoupling Piezoelectric And Pyroelectric Effects In Anisotropic Polymer-Ceramic Lattices Produced Via Fused Filament Fabrication, Sofia Alexandra Perez

Open Access Theses & Dissertations

This thesis investigates how multi-material fused filament fabrication (FFF) can be used to engineer lattice structures that decouple piezoelectric and pyroelectric responses within a single polymer–ceramic composite. A hybrid ABS–BaTiO3/PLA lattice—referred to as the Hybrid PIZCAL—was designed to direct mechanical strain along the Z-axis while suppressing deformation in the transverse directions. After thermal poling, the lattice exhibited a 293% increase in Z-axis voltage sensitivity compared to a monolithic ABS–BaTiO3 cube and significantly reduced off-axis electromechanical output. Finite element simulations and directional compression testing confirmed that geometric anisotropy and material zoning produce strong, axis-selective piezoelectric behavior. The second part of this …