Digital Commons Network^™

Contribution To The Chemotherapy Of Human Trypanosomiasis: Design, Synthesis, And Biological Evaluation Of Dimeric 2-Nitroimidazoles Against Trypanosoma Cruzi Amastigotes And Bloodstream Trypanosoma Brucei, Afonso Santine M.M. Velez, Otavio Augusto Chaves, Carlos Serpa, Fatma M. Salem, Bibo Li Ph.D., Bin Su Ph.D., Celio Geraldo Freire-De-Lima, Debra Decote-Ricardo, Marco Edilson Freire De Lima

Biological, Geological, and Environmental Faculty Publications

Effective and safe treatments for neglected tropical diseases caused by parasites, such as Chagas disease and sleeping sickness, remain lacking, posing a significant challenge for researchers worldwide. The rational design of dimeric compounds inspired solely by the pharmacophoric core of benznidazole (2-nitroimidazole) has proven to be a promising strategy for antiparasitic development. Thus, in the present work, it was increased the linker between the active units (2-nitroimidazole) to improve the interaction with TcNTR, facilitating the bioactivation of the longest dimers. Biological assays confirmed this, demonstrating that all compounds were active against replicative intracellular amastigotes of Trypanosoma cruzi (Tulahuen C2C4-LacZ). Notably, …

Investigating The Knowledge, Attitudes And Practices Towards Type 2 Diabetes Mellitus In A Student Population In The United Kingdom: A Quantitative Study, Philip Boadu Anim

Theses

Aim: To explore the knowledge on the risk factors, signs and symptoms, management, and complications of Diabetes, attitudes, and practices towards prevention of Diabetes Mellitus among university students in the United Kingdom.

Methods: The researcher utilised a quantitative study design in carrying out the study. The study was conducted at Cardiff Metropolitan University with Cardiff Met students being the target population. Thirty (30) participants were recruited through convenient sampling. Data was collected through questionnaires using closed ended questions. The Statistical Package for Social Science (SPSS) version 27 as used to analyse the data collected. Statics were performed to form a …

Neighborhood-Level Deprivation Measures In The United States: A Scoping Review And Reference Guide For Investigators, Jaesung Choi, Madeline R Horan, Mary G Nusloch, Yikyung Park, Gregory T Armstrong, Melissa M Hudson, Kirsten K Ness, I-Chan Huang

2020-Current year OA Pubs

PURPOSE: The extent to which existing measures cover the spectrum of neighborhood-level social determinants of health (SDOH) has not yet been assessed. This review compared the content of U.S.-based neighborhood-level SDOH measures and summarized the use of these measures in empirical research. METHODS: We conducted a comprehensive search on PubMed and Google Scholar, identifying review articles published from 1990–2023, and complemented this search by manually examining the original articles on measure development. We identified 85 measures and categorized them into two groups (42 with a specific name and 43 with no name) and used a framework including 14 domains of …

Impact Of Apitegromab On Motor Function In Spinal Muscular Atrophy, Jordyn Linfield, Ashley Jacob, Haylee Whyde, Owen Fox, Kaitlyn Bowden, Connor Dains, Brenna Hissong, Manoranjan D'Souza

Pharmacy and Wellness Review

Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder characterized by the progressive loss of alpha motor neurons in the anterior horn of the spinal cord, leading to muscle weakness, atrophy, and impaired motor function.¹ SMA remains an extensive and difficult-to-treat condition, with only three disease-modifying therapies currently available to patients. A new investigational agent with a unique mechanism of action, apitegromab (SRK-015), has shown promising results in recent clinical trials. The safety and efficacy of apitegromab in patients with SMA have been explored in several clinical trials, with the TOPAZ and SAPPHIRE studies being the most notable. This …

Fda Approval Of The Eversense 365 Continuous Glucose Monitoring System: A New Era In Long-Term Glucose Monitoring, Kiley Devoll, Alexander Defranco, Kennedy Kosikowski, Anna Spalvieri, Macy Davis, Connor Dains, Brenna Hissong, Emily Eddy

Pharmacy and Wellness Review

Eversense 365 is an implantable continuous glucose monitoring (CGM) system designed to provide accurate glucose measurements for up to 365 days. Current clinical guidelines recommend CGM use for patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), with evidence demonstrating benefit in patients with T2DM regardless of concurrent insulin use. Healthcare providers play a key role in patient education and are well-positioned to support the adoption of long-term CGM technologies, including Eversense 365. The safety and efficacy of the 365-day CGM have been evaluated across a series of clinical trials, which demonstrate clinically meaningful improvements in …

High-Dose Oral Pyrophosphate Inhibits Connective Tissue Calcification In Abcc6 Null Mice But May Affect Bone Structure, Ibtesam Rajpar, Nicholas Yancy, Jacob Beiriger, Christina Shao, Syed Naqvi, Deana Mancuso, Fatemeh Niaziorimi, Ryan E Tomlinson, Koen Van De Wetering

Department of Orthopaedic Surgery Faculty Papers

Pseudoxanthoma elasticum (PXE) is a rare inherited disorder marked by abnormal calcium phosphate deposition in soft connective tissues, particularly the skin, arteries, and eyes. It is caused by inactivating mutations in the ABCC6 gene, which encodes a hepatic efflux transporter. Loss of ABCC6 function leads to reduced plasma levels of pyrophosphate (PPi), a key inhibitor of calcification, thereby promoting ectopic mineralization. Oral PPi therapy has emerged as a potential treatment, but its effectiveness is uncertain. Most ingested PPi is hydrolyzed in the gut to inorganic phosphate, which may worsen calcification. Moreover, its impact on mineralized tissues remains largely unexplored. Abcc6−/− …

High School Dropout Rates Among Latin Students In The United States, Taryn T. Marriott

Student Works

An ongoing concern of educators and community members is the disproportionately high amounts of Latinx students dropping out of high school in the United States. Although there has been notable research done and action taken, the problem still remains. Lack of familial support, discrimination, and residence in low-income areas all contribute to the low retention rates of Latinx youth on track to graduate high school. As a result, youth who do not complete their education and set their sights on career goals have a harder time with employment, communicating in their society, and tend to show higher levels of engagement …

Clinical Practice Guideline: Self-Care Management For Patients With Chronic Obstructive Pulmonary Disease (Copd), Scholastica Nnedimma Ihejirika

Walden Dissertations and Doctoral Studies

Summary The DNP project is a clinical practice guideline (CPG) quality improvement project to guide nurses in caring for patients admitted with chronic obstructive disease (COPD). The quality issue identified was an increased readmission rate for patients with COPD in the facility, of which knowledge and awareness remain extremely low. An annual target of 19.36% was set by the facility to track the readmission rate of patients with COPD, and according to statistics from the facility, from July 2021 to June 2022, the rate was 25.7%; from July 2022 to June 2023, the readmission rate increased to 26%, thus necessitating …

Employing Ai Tools To Predict Features For Dental Care Use In The United States During The Global Respiratory Illness Outbreak, Preeti Pushpalata Zanwar, Hamid-Reza Kodan-Ghadr, Vijayakumar Thirumalai, Suad Ghaddar, Shuo Jim Huang, Beth Harkness, Eben Rey, Romanch Shah, Sairaja Reddy Kurelli, Jay S. Patel

Health & Biomedical Sciences Faculty Publications

No abstract provided.

Intouch Week Of January 12, 2026, New York Medical College

InTouch

• Department of Cell and Molecular Physiology Unites Three Disciplines
• Paul Arnaboldi, Ph.D., Receives More Than $500,000 NIH Grant to Support Respiratory Vaccine Development
• Action speaks louder than words in dealing with antisemitism and violence
• Celebrate the Publication of the 8th Edition Principles and Practice of Radiation Oncology
• Gabriel Project Mumbai, Welcomes Second Cohort of TCDM Students and Faculty
• Love at NYMC
• Student Spotlight: A Full-Circle Journey

Adaptable Psychopathic Traits: Military And Para-Military Organizations, Mariana Ramirez

Student Theses

Although culturally distinct, both military and law enforcement careers demand individuals to operate effectively in high-risk environments; a characteristic shaped through processes of military and para-military occupational socialization, reinforced by an adaptable personality. Understanding the distinctions between military and law enforcement cultures provides a foundation for examining individual-level factors such as personality, behavior, and mental health. Recent research (e.g. Anestis et al., 2019; Batastini et al., 2023; Falkenbach et al., 2017; Falkenbach et al., 2018; McKinley & Verona, 2023; Patton et al., 2018; Preston et al., 2020; Roșca et al., 2021) has increasingly applied a psychopathic framework to study these …

Systemic Risk And Macroprudential Regulation, Seraina Grünewald, Jeremy Kress

Law and Contemporary Problems

No abstract provided.

The Divergence Of Mandatory Climate Disclosure In The United States And European Union, Alessio M. Pacces, David Zaring

Law and Contemporary Problems

No abstract provided.

Sustainability Assurance, Luca Enriques, Alessandro Romano, Andrew F. Tuch

Law and Contemporary Problems

No abstract provided.

Report On A Self-Directed Pilot Study (For Students), Yoshihiko Ariizumi

Spiritual Proficiency

Level Up Your Life: The Science of Spiritual Growth

Ever feel like you're stuck in "mental noise" or struggling to stay focused? This study explores how a simple 4-week routine can literally "accelerate" your brain and emotional resilience. By using checklists and specific mental "switches," I found that we can turn daily frustrations into moments of gratitude and even boost our ability to learn complex subjects. This isn't just about faith; it's about a practical "system" to help you stay calm, sharp, and connected to your higher purpose in a busy world.

Alcohol And The Endocrine System: A Critical Review Of Disruptions, Potential Mechanisms, And Health Implications, Patricia E. Molina, Liz Simon

School of Graduate Studies Faculty Publications

The endocrine system coordinates and integrates cellular activity throughout the body by regulating cellular and organ function and maintaining homeostasis. Homeostasis, the dynamic maintenance of internal balance despite changing external or internal conditions, is essential for proper cellular function. The endocrine system achieves this through a complex regulatory network of hormone-mediated signaling among multiple endocrine organs, relying on precisely regulated synthesis and release of hormones and specific hormone-receptor interactions. Endocrine-mediated actions coordinate critical physiological processes, including growth, metabolism, reproduction, stress adaptation, and circadian rhythms throughout the lifespan. Endocrine glands—such as the hypothalamus, pituitary, thyroid, parathyroid glands, pancreas, adrenal glands, and …

The 2024 Carlisle Conference On The Pla: Protracted War Against The Prc, Joshua Arostegui

Books, Monographs & Collaborative Studies

The US Army War College’s 2024 Carlisle Conference on the People’s Liberation Army was held on October 16 and 17 at Carlisle Barracks, Pennsylvania. The conference featured keynote speakers from the US Department of Defense and the think-tank community, and panels focused on assessing the People’s Republic of China’s understanding of and capability to carry out a protracted war in the Indo-Pacific. The conference brought together over 100 participants from government, military, US Intelligence Community, academic, and think-tank organizations.

The conference papers were authored by expert speakers and panelists and were designed to provide insight into key People’s Republic of …

Kindergarten Teachers’ Experiences And Training With Critical Reflection To Support Adaptive Teaching, Tessa Cushman

Walden Dissertations and Doctoral Studies

The problem that was addressed in this study is that kindergarten teachers often lack training in critical reflection as part of their adaptive teaching practice. Despite much research on critical reflection, there was a lack of knowledge regarding training kindergarten teachers receive on critical reflection and how they use it to adapt their teaching. The purpose of this study was to explore the experiences of kindergarten teachers regarding the training they received on critical reflection and the support they felt they needed to implement critical reflection for an adaptive teaching practice. Schön’s reflective practice theory was the conceptual framework for …

Development Of An Educational Intervention To Enhance Nurses’ Knowledge And Intent To Implement Evidence-Based Diabetes Self-Management In Clinical Practice, Anne Marie Sieyou Ngouane

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) project was purposed with closing critical gaps in staff knowledge and adherence to diabetes self-management protocols in a busy primary care clinic. Rising readmission rates and uneven use of American Diabetes Association (ADA) standards signaled an urgent need for a structured approach to staff education. To address this, a one-hour interactive training session was created that blended teaching, evidence-based handouts, and a practical diabetes care checklist. Staff learning was measured through pretest and posttest, confidence and adherence used a 5-point Likert-scale survey, and 21day readmission data tracked patient outcomes. The project question asked if …

Enhancing Anxiety Identification In Adult Patients, Wonda Crump

Walden Dissertations and Doctoral Studies

In this Doctor of Nursing (DNP) project, I focused on implementing a staff education program for anxiety screening at a health and wellness clinic. Mental health conditions, particularly anxiety disorders, are common in primary care settings. Research shows that anxiety affects millions of adults, yet many cases remain undiagnosed. The practice problem that I identified was that many patients with anxiety disorders were going undiagnosed during regular clinic visits. The clinic had no standard process for screening anxiety, and staff members had a knowledge deficit on the proper use of anxiety assessment tools. This gap in practice led to missed …

Exploring Juvenile Justice System Social Workers’ Dual Role Conflicts, Tayler Janet Deggendorfer

Walden Dissertations and Doctoral Studies

Social workers working within the juvenile justice system face challenges in managing dual roles of providing social support for clients in a punitive environment of incarceration. The problem that was explored in this study is the ethical and practical dilemmas of dual roles for social workers—specifically the potential for burnout and mental health injury for social workers who work within the parameters of both roles. The purpose of this qualitative descriptive phenomenological study was to explore the lived experiences of a selected criterion sample of social workers. The study was framed by Goffman’s role theory. Oral narrative data were collected …

Evaluation Of Unmet Needs Of Vulnerable Populations And At-Risk Communities Through Disaster Management Planning, Ryan Austin Crowe

Walden Dissertations and Doctoral Studies

This community-based non-profit organization aimed to aid those most in need by providing critical social services. The client organization has been selected numerous times as a recipient of federal disaster case management programs, often not until a year after the disaster, resulting in distrust of the federal government and organizations contracted to perform recovery services. Providing services to areas impacted has been difficult due to contract delays. The practice research question addressed in this study was: How can a client organization address the one-year service gap frequently associated with federal contracts through a disaster management planning system? The purpose of …

High-Sensitivity Cardiac Troponin I And Frailty: Associations With The Frailty Index And Fried Phenotype In Older Women, Jedd Pratt, Abadi K. Gebre, Carlos J. Toro-Huamanchumo, Elsa Dent, Trent Bozanich, Wai E. Lim, Elizabeth Byrnes, Julee Mcdonagh, Caleb Ferguson, Craig Sale, Kun Zhu, Carl Schultz, Richard L. Prince, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Despite the nexus between cardiovascular health and frailty, the relevance of high-sensitivity cardiac troponin I (hs-cTnI), a biomarker of myocardial injury, to frailty is poorly understood. We examined whether hs-cTnI concentrations were associated with frailty in a well-characterized cohort of older women. A total of 1151 community-dwelling women from the Perth Longitudinal Study of Aging Women (mean age ± SD = 75.2 ± 2.7 years) were included. Frailty was operationalized using a validated frailty index (FI) of cumulative deficits and a modified Fried phenotype. Plasma hs-cTnI were categorized into quartiles. Cross-sectional associations between hs-cTnI quartiles and frailty were assessed using …

Self-Efficacy Change Among Diverse Family Caregivers In Dementia Care, Deborah M Oyeyemi, Erich J Greene, Yunshan Xu, David R Lee, Rafael Samper-Ternent, Maya L Lichtenstein, Alan Stevens, Jeff D Williamson, Arun S Karlamangla, Debra Saliba, David B Reuben

Faculty, Staff and Student Publications

Objectives: To determine whether changes in caregiver self-efficacy (beliefs about one's ability to manage dementia-related problems and access help) differed by caregiver race and ethnicity across all participants enrolled in a large pragmatic trial of comprehensive dementia care.

Methods: In the Dementia Care Study (D-CARE), community-dwelling older adults with dementia and their unpaid family caregivers were randomized to receive usual care, community-based, or health system-based comprehensive dementia care. Caregiver self-efficacy was assessed at baseline, 6 months, and 18 months using a 4-item scale (range 4-20, higher scores indicate greater self-efficacy). Among all caregivers, we compared least squares means for overall …

Usaid Grant Recipient Data Fy2002-2025, Susan Turner Haynes

Faculty Works

Grant recipient data from USAID from fiscal years 2002-2025.

Fda Policy Shift On Clinical Efficacy Study Requirements For Monoclonal Antibody Biosimilars, Rileigh Rahrig, Madilyn Paphanchith, Allie Honigford, Daniella Egbujor, Haley Brown, Jenny Magana Figueroa, Connor Dains, Brenna Hissong, Kyle W. Parker

Pharmacy and Wellness Review

Biologic products are widely used in the treatment of various disease states, including rheumatoid arthritis, inflammatory bowel disease, cancers, and genetic diseases. These products are derived from proteins and genes produced by living organisms and are subsequently used to treat specific disease states. Due to the complexity of biological products, the costs of research and production are high. Currently, the United States approval pathway requires extensive testing for biologics to be designated as biosimilars, meaning there are no clinically meaningful differences in safety or purity of their active components. These required tests can be redundant, as biosimilars are developed using …

Play-Based Curriculum, Marina E. Prawdzik

Masters Projects

This project addresses the drastic decline of play and play-based learning in public education early childhood settings. Kindergarten classrooms have shifted their focus more to academics in the form of lecture based learning and lessons, rather than play based learning techniques. Because of this, children are lacking in cognitive development, physical development and social and emotional development and growth. This project includes research from within the state of Michigan, research within the United States as a whole, and research about play based learning from other countries such as Nigeria, Mexico, South Africa, Kenya, Finland, and Germany.

Message From The President, Georgia Southern University

Messages from the President

No abstract provided.

Tumor-Infiltrating Bacteria Disrupt Cancer Epithelial Cell Interactions And Induce Cell-Cycle Arrest, Jorge Luis Galeano Niño, Falk Ponath, Victor A Ajisafe, Clara R Becker, Andrew G Kempchinsky, Martha A Zepeda-Rivera, Javier A Gomez, Hanrui Wu, Jessica G Terrazas, Heather Bouzek, Elizabeth Cromwell, Pritha Chanana, Matthew Wong, Ashish Damania, Michael G White, Y Nancy You, Scott Kopetz, Nadim J Ajami, Jennifer A Wargo, Christopher D Johnston, Susan Bullman

Faculty, Staff and Student Publications

Tumor-infiltrating bacteria are increasingly recognized as modulators of cancer progression and therapy resistance. We describe a mechanism by which extracellular intratumoral bacteria, including Fusobacterium, modulate cancer epithelial cell behavior. Spatial imaging and single-cell spatial transcriptomics show that these bacteria predominantly localize extracellularly within tumor microniches of colorectal and oral cancers, characterized by reduced cell density, transcriptional activity, and proliferation. In vitro, Fusobacterium nucleatum disrupts epithelial contacts, inducing G0-G1 arrest and transcriptional quiescence. This state confers 5-fluorouracil resistance and remodels the tumor microenvironment. Findings were validated by live-cell imaging, spatial profiling, mouse models, and a 52-patient colorectal cancer cohort. Transcriptomics reveals …

Spatial Omics At The Forefront: Emerging Technologies, Analytical Innovations, And Clinical Applications, Yunhe Liu, Yibo Dai, Linghua Wang

Faculty, Staff and Student Publications

Spatial omics transforms our understanding of cancer by revealing how tumor cells and the microenvironment are organized, interact, and evolve within tissues. Here, we synthesize advances in spatial technologies that map tumor ecosystems with unprecedented fidelity. We highlighted analytical breakthroughs-including multimodal integration and emerging spatial foundation models-that resolve functional niches and spatial communities, converting spatial patterns into mechanistic insights. We summarize how spatially organized features, from immune hubs to microbiota and neural interfaces, shape tumor evolution and clinical outcomes. We then outline how spatial approaches illuminate precancer biology, metastatic adaptation, and therapy response. Bridging discovery and translation, we provide a …