Digital Commons Network^™

Tet2-Mutant Clonal Hematopoiesis Enhances Macrophage Antigen Presentation And Improves Immune Checkpoint Therapy In Solid Tumors, Shelley Herbrich, Mehdi Chaib, Swetha Anandhan, Samuel W Andrewes, Ashwat Nagarajan, Baoxiang Guan, Nishant Gandhi, Jared Gilliam, Milan Radovich, Padmanee Sharma

Faculty, Staff and Student Publications

Clonal hematopoiesis (CH) is detectable in upwards of 20% of patients with solid tumors and is associated with worsened prognosis; however, its role in tumor immunology and immune checkpoint therapy (ICT) is unknown. Using a bone marrow chimera model of Tet2+/mut CH in mice with solid tumors, we found the Tet2-mutant myeloid cells are abundant in the tumor microenvironment and contributed to an improved response to ICT. Mechanistically, Tet2+/mut macrophages inside the tumor act as immunogenic antigen-presenting cells that more effectively cross-prime naive CD8+ T cells in response to IFNγ. In human cohorts of 35,971 non-small cell lung cancer patients …

Adipose Stromal Cell-Derived Cancer-Associated Fibroblasts Promote Pancreatic Adenocarcinoma Progression Through Sfrp4 Signaling, Joseph Rupert, Lingyi Cai, Alexes C Daquinag, Dimitris Anastassiou, Mikhail G Kolonin

Faculty, Staff and Student Publications

Background/objectives: Progression of pancreatic ductal adenocarcinoma (PDAC) and other carcinomas relies on cancer-associated fibroblasts (CAFs). A subset of CAFs is derived from adipose stromal cells (ASCs) recruited by tumors and the ASC-CAF conversion has been associated with invasiveness and poor prognosis.

Methods: To explore the underlying molecular mechanisms, we used a model based on primary ASCs derived from human visceral adipose tissue co-cultured with human PDAC cell line Capan-1. To investigate cancer progression in vivo, we also used mice orthotopically grafted with mouse KPC cells.

Results: Genomic analysis revealed that Capan-1 co-culture induces Wnt and TGFβ signaling and extracellular matrix …

Arrhythmia Following Congenital Heart Disease Surgery In Oman: Incidence And Risk Factors – A Prospective Study, Shamsa Al Kaabi, Eslam Mohammed, Tamer Abosalem, Hilal Al Riyami, Ismail Al Abri, Mohammed Al Ghafri

Sultan Qaboos University Medical Journal

Objectives: This study aimed to determine the incidence, outcomes and risk factors of arrhythmia in children undergoing congenital heart disease (CHD) surgery in Oman. Methods: This prospective cohort study was conducted between 2023 and 2024 at the National Heart Centre, Muscat, Oman. Paediatric patients who underwent CHD surgery were included; those with preoperative arrhythmia or permanent pacemakers were excluded. Demographic, intraoperative and postoperative variables were collected. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of postoperative arrhythmia. Results: A total of 346 patients were included in this study, of which 49 (14.2%, 95% confidence …

2026-01-12 Message From The President, Morehead State University. Office Of The Provost.

Staff Congress Records

Message sent on January 12, 2026 by the President to the campus community regarding upcoming dates of importance, congratulatory recognitions, and the New Carnegie Designation.

Dynamic Fib-4 Score Changes And Hcc Risk In Patients With Masld And Elevated Liver Enzymes: A Nationwide Cohort Study, Yee Hui Yeo, Hsiu J Ho, Tsai-Wei Huang, Teng-Yu Lee, Ju Dong Yang, George Cholankeril, Chien-Jen Chen, Hawi-I Yang, Chuen-Fei Chen, Hung-Chuen Chang, Chun-Ying Wu

Faculty, Staff and Students Publications

Introduction: Hepatocellular carcinoma (HCC) can develop in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) without cirrhosis, especially in those with elevated liver enzymes. However, there is currently no low-cost, scalable screening tool for this population. To address this need, we investigated the association between serial changes in FIB-4 (fibrosis-4) scores over a 3-year period and the risk of developing HCC in a large, diverse cohort of patients with MASLD without cirrhosis.

Methods: This study utilized a nationwide cohort from the National Health Insurance Research Database (NHIRD), including 810,698 patients with MASLD who had demographic and laboratory data at baseline …

Investigating Age-Related Decline In Sensorimotor Control Using Robotic Tasks, Laura Alvarez-Hidalgo, Ellie Edlmann, Gunnar Schmidtmann, Ian S. Howard

School of Health Professions

Aging is associated with changes in sensorimotor control that contribute to functional decline, mobility limitations, and increased fall risk. Traditional motor assessments often rely on subjective measures, highlighting the need for objective, quantitative tools. We developed three robot-based tasks using the vBOT planar manipulandum to evaluate sensorimotor performance in healthy young (<35 years) and older (>60 years) adults. These tasks uniquely combined bimanual control and altered dynamic conditions to assess age-related differences. The first task required bimanual coordination to control a virtual 2D arm over 400 center-out and return trials, targeting de novo motor learning. The second task involved unimanual reaching with the …

Chek2 Loss Endows Chemotherapy Resistance To Hematopoietic Stem Cells, Jing Zhou, Tianyuan Hu, Dian Li, Sanming Li, Minhua Li, Xiangguo Shi, Daisuke Nakada

Faculty, Staff and Students Publications

Individuals with history of chemo- or radiotherapy frequently exhibit somatic mosaicism in the blood, often involving mutations in genes responsible for DNA damage responses (DDR), such as CHEK2. However, the mechanisms by which CHEK2 mutations promote the expansion of mutant cells following chemo- or radiotherapy remain poorly understood. Here, we demonstrate that loss of CHEK2 confers resistance to chemotherapy in hematopoietic stem and progenitor cells (HSPCs). Through a CRISPR-based screen, we identified CHEK2 as a gene whose loss enhances resistance to cytotoxic chemotherapies. A complementary drug screen revealed that CHEK2-mutant cells are also resistant to DNA hypomethylating agents. Chek2-deficient HSPCs …

Creating Sustainable School And Home Gardens: Misconceptions About Bees, Kaitlin U. Campbell, Kathy Cabe Trundle, Rita Hagevik

All Current Publications

Bees are fascinating creatures that play a crucial role in pollination and ecosystem health. However, misconceptions about bees are widespread. Understanding the facts about bees helps us appreciate their significance and take appropriate action to protect them. This fact sheet dispels common myths about bees and explains the facts behind the misconceptions.

Optimal Drought Management Actions For Cattle Operations On Navajo Nation, Tatiana Drugova, Kynda R. Curtis, Man-Keun Kim

All Current Publications

In this fact sheet, we examine the drought management options available to cattle operations on the Navajo Nation, the largest Native American reservation in the U.S. Specifically, we discuss the results of a study evaluating the economic outcomes of two common drought response strategies: herd reduction and supplemental hay purchases. We also provide recommendations for ranchers on optimal strategies, i.e., those that maximize profits, for two rancher types, differentiated by their willingness to accept (risk-neutral) or avoid risk (risk-averse).

Germline Hla Heterozygosity Is Associated With Decreased Lung Cancer Risk, Taotao Tan, Vikram R Shaw, Jinyoung Byun, Hyun-Sung Lee, Younghun Han, Yafang Li, Rayjean J Hung, David C Christiani, Xin-An Wang, Mattias Johansson, Xiangjun Xiao, David Zaridze, Stig Egil Bojesen, Sanjay Shete, Demetrios Albanes, Melinda C Aldrich, Adonina Tardon, Guillermo Fernandez-Tardon, Loïc Le Marchand, Gad Rennert, Heike Bickeböller, H-Erich Wichmann, Angela Risch, John K Field, Michael Davies, Penella Woll, Lambertus A Kiemeney, Aage Haugen, Shanbeh Zienolddiny, Stephen Lam, Mikael Johansson, Kjell Grankvist, Matthew B Schabath, Angeline Andrew, Philip Lazarus, Susanne M Arnold, Dakai Zhu, Maria Teresa Landi, James Mckay, Christopher Amos, Chao Cheng

Faculty, Staff and Students Publications

Heterozygosity at human leukocyte antigen (HLA) loci may improve lung cancer immunosurveillance by increasing recognition of the tumor by the immune system. Previous studies utilizing data from population-level biobanks, such as the United Kingdom Biobank and FinnGen, have identified an association between germline HLA class-II heterozygosity and reduced lung cancer risk in smokers. In the present study, we evaluate the association between HLA heterozygosity and lung cancer in a large case-control study (15,302 cases; 14,580 controls) with imputed HLA allele-type information, comparing differences in HLA heterozygosity between smokers and non-smokers, amongst lung cancer subtypes, and at 2- and 4-digit HLA …

Assessing Localized Recovery And Synchrony Of An Endangered Wetland Species., Aiyana Reissman

Theses

The state and federally endangered light-footed Ridgway’s rail (LFRR; Rallus obsoletus levipes) is central to regional conservation, yet the drivers of its population fluctuations remain poorly understood. The fragmented nature of coastal wetlands in Southern California is threatening the existence of endemic species like the LFRR. Tidal inundation, severe storms, and overpredation threaten the survival of LFRR. This study addresses population fluctuations by analyzing the spatial and temporal drivers of LFRR populations to inform effective, site-specific management.

To do this, a 45-year (1980–2024) LFRR census data set across 16 wetlands throughout its range in California was synthesized. A multi-faceted …

Excess Risk Of Fracture In Incident Parkinson's Disease Medicare Beneficiaries, Alejandra Camacho-Soto, Irene M Faust, Brittany Krzyzanowski, Jordan A Killion, Kassu M Beyene, Edward F Ellerbeck, Jacob J Sosnoff, Brad A Racette

2020-Current year OA Pubs

BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by both motor and non-motor symptoms. Falls and fractures are common in advanced PD but the risk of fractures in newly diagnosed people with PD and the impact of treatment with levodopa is understudied.

METHODS: We investigated the risk of fractures among Medicare beneficiaries with incident PD age ≥ 67 compared to controls. Among PD cases only with continuous Part D medication coverage, we examined the effect of levodopa treatment on fracture risk. We identified incident PD cases (N = 68,150) within a population-based sample of 2017 Medicare …

Andres Macias-Chamaidan V. Attorney General United States Of America

2026 Decisions

Agency

Social Prescribing Within Five European Countries: A Protocol Of A Cross-Country Qualitative Analysis, Stephanie Tierney, Debra Westlake, Farhad Rezvani, Daniela Rojatz, Juliane Köberlein-Neu, Trutz Bommhardt, Sónia Dias, Maria João Marques, Donata Kurpas, Hendrik Napierala, Wolfram Herrmann, K Husk

Peninsula Medical School

Introduction Social prescribing is an approach to addressing non-medical issues affecting people’s health and well-being (eg, loneliness, housing or financial problems). It has gained international traction over recent years as complementary to medical care. A larger research project, comparing social prescribing across European countries, is considering how to tailor provision for the following groups: (a) LGBTIQ+persons, (b) refugees and first-generation immigrants and (c) older adults living alone. As part of this research, a qualitative study will address the question: What are the enabling and limiting factors associated with implementing social prescribing, across different European countries, from the perspective of key …

The Phyrfly Opus: A Unified Standard For Hyperdimensional Time Vectors, Spectrally Isolated Coordination, Neural Hierarchies, And Distributed Proprioception, Steven Kirkland

Defensive Publications Series

This monograph establishes 264 prior art claims for a decentralized, connectionless timing and positioning architecture comprising the UTLP, RFIP, and SMSP protocol triad. It formalizes the PHYRFLY nomenclature to distinguish low-level, hardware-scheduled Physical-Layer synchronization primitives from higher-level application orchestration. The core novelty centers on a Vector Time Representation, encoding temporal state as 8 phase values (ticks modulo coprime integers 211–251) transmitted in 8 bytes, then expanded locally into ~10,000-dimensional hyperdimensional chord vectors for similarity computation and drift estimation. This cyclic encoding enables automatic phase-lock convergence within 5–10 beacon exchanges regardless of initial offset, with the Chinese Remainder Theorem guaranteeing unique …

Beyond The Classroom: Physiological Stress Of Academic Travel, Whitley J. Stone, Paula Upright, Stacey Forsythe

International Journal of Exercise Science: Conference Proceedings

Long-distance travel is often celebrated as an opportunity for growth, but its physiological and cognitive consequences are rarely addressed in academic contexts. PURPOSE: This study investigated the physiological and cognitive effects of long-distance travel on university students journeying from the Southeastern U.S. to Hawaii. METHODS: Using a repeated measures design, participants were assessed at baseline (pre-travel) and across the first four days on island (post-travel). RESULTS: Results from a repeated measures ANOVA revealed significant disruptions in cardiovascular and stress markers. Average daily heart rate increased markedly across the trip (F(4,56)=12.96, pn=38 participants for CRF, n=71 for PSS, n=124 …

A Multi-Stage Pilot Study To Develop Procedures To Examine Diversity, Equity & Inclusivity (Dei) Statements Within Kinesiology Journal Submission Guidelines, Vivianne Felker, Zoe Howard, Jafra D. Thomas, Shannon R. Siegel, Shiina Tsuchiya, Jorge Portillo, Deanna Jun, Alexis V. Willing, Jill M. Maples, James W. Navalta, Matthew J. Garver, Joel D. Reece, Dustin W. Davis

International Journal of Exercise Science: Conference Proceedings

While diversity, equity, and inclusivity (DEI) principles support ethically responsible, cost-effective, evidence-supported health promotion and performance interventions, they are rarely addressed within published biomedical/behavioral science research, including in kinesiology. PURPOSE: Because journal submission guidelines could increase integration of DEI principles’ application, we sought to develop a valid and reliable procedure to quantify DEI statements within kinesiology-related journal submission guidelines. METHODS: The pilot study was conducted between 2023 and 2025. Faculty investigators developed a codebook with good content validity (100% consensus achieved), then the primary faculty investigators produced a written protocol and coding form to standardize the coding process. …

Effects Of Acute And Multi-Day Beetroot Juice Supplementation On Power And Velocity Of Ncaa Division I Baseball Players, Justin M. Foster, Raymond T. Gerardo, Sydney N. Brennan, Trevor J. Molnar, Ryan Tran, Kyle S. Geppert, Christopher B. Sottile, Michael Egiazarian, Abigail F. Ballhagen, Stewart D. Gonzalez, Adam Pennell, Rachel Tan

International Journal of Exercise Science: Conference Proceedings

Dietary nitrate supplementation can enhance power via modulating type II muscle fiber contractility; however, no study has examined the ergogenic potential of nitrate in elite level power-based athletes that heavily rely on type II muscle fiber activation such as baseball players. Moreover, there are no nitrate dosing guidelines available for elite level athletes. PURPOSE: To investigate if acute and multi-day nitrate supplementation influences power and velocity during barbell back squat and barbell bench press in elite level baseball players. METHODS: Eighteen male collegiate baseball athletes (NCAA Division I) reported to the laboratory for 6 visits over ~8 weeks, and were …

Effect Of Sodium Bicarbonate On Gastrointestinal Injury During Repeated Sprints In The Heat, Ozan Kumbasar, Jonathan W. Specht, Marissa Ramirez, Jennifer Raef, Mackenzie Schwartz, Alyssa R. Bailly, Oscar Chavez Jr., Jade X. Dawson, Jessica Apodaca, Raul Freire, Withley C. Atkins, Flávio De Castro Magalhães, Jason Siegler, Fabiano T. Amorim

International Journal of Exercise Science: Conference Proceedings

Sodium bicarbonate (SB) is a widely used supplement that can enhance repeat sprint performance; however, a common side effect is gastrointestinal (GI) distress. Exercise in the heat can cause intestinal injury and endotoxemia, but no study has examined whether SB heightens this injury. PURPOSE: To determine whether SB ingestion exacerbates intestinal discomfort, injury, and endotoxemia during repeated sprints in the heat. METHODS: Ten endurance-trained athletes (6 male) completed randomized, counterbalanced, double-blind trials in which they ingested capsules containing SB (0.2 g·kg⁻¹ body mass) or placebo following a high-carbohydrate meal. The trials consisted of a 22-min warm-up followed by …

Dietary Nitrate Supplementation Worsens Resistance Exercise Performance In Resistance-Trained Females, Sydney N. Brennan, Raymond T. Gerardo, Trevor J. Molnar, Justin M. Foster, Ryan Tran, Kyle S. Geppert, Christopher B. Sottile, Michael Egiazarian, Abigail F. Ballhagen, Stewart D. Gonzalez, Adam Pennell, Rachel Tan

International Journal of Exercise Science: Conference Proceedings

Dietary nitrate supplementation appears to preferentially target type II muscle fibers for beneficial effects; however, research examining the efficacy of nitrate in females and resistance exercise is scarce. PURPOSE: To investigate if dietary nitrate, provided as concentrated nitrate-rich beetroot juice (BR), improved resistance exercise performance in back squat and bench press compared to nitrate-depleted beetroot juice (PL) in resistance-trained females. METHODS: Eighteen resistance-trained females aged reported to the lab for a total of four visits over a 2-week period. Participants performed a one repetition maximum protocol (1RM) and familiarization to the experimental protocol, and were assigned in a randomized, double-blind …

Acute And Chronic Dietary Nitrate Supplementation On Resistance Exercise Performance In Healthy Resistance-Trained Adults., Trevor J. Molnar, Sydney N. Brennan, Justin M. Foster, Ryan Tran, Raymond T. Gerardo, Kyle S. Geppert, Christopher B. Sottile, Michael Egiazarian, Abigail F. Ballhagen, Stewart D. Gonzalez, Adam Pennell, Rachel Tan

International Journal of Exercise Science: Conference Proceedings

The efficacy of dietary nitrate supplementation for enhancing resistance exercise remains unclear, and nitrate dosing guidelines are relatively unexplored. PURPOSE: To determine whether acute and chronic dietary nitrate supplementation, provided in the form of nitrate-rich beetroot juice (BR), can improve resistance exercise performance in resistance-trained males. METHODS: Thirty-six resistance-trained males and females will be recruited. Participants will complete a standardized one-repetition maximum (1RM) test in barbell back squat and barbell bench press and a familiarization prior to experimental visits. In a randomized, double-blind, controlled, fashion, participants will complete two conditions of 14-day supplementation periods to consume: (1) nitrate-depleted beetroot juice …

Muscle Damage Across Menstrual Cycle Phase, Jeromea "Jiji" Pollock Ph.D.

International Journal of Exercise Science: Conference Proceedings

The Muscle Damage Across Menstrual Cycle Phase (MuDAM) study examined estrogen’s critical role in muscle recovery after muscle damage to the knee flexors. Knee flexor strength plays a critical role as antagonist muscles to provide stability to the knee joint during the deceleration phase of sprinting, particularly during change of direction movements. PURPOSE: The purpose of the study was to identify the rate of delayed onset muscle soreness (DOMS), pain, and performance during Phase 1 (low levels of estrogen and low levels of progesterone); Phase 2 (peak levels of estrogen and low levels of progesterone); and Phase 4 (peak levels …

Anticipation Effects On Landing Error Scoring System Performance: Highlighting The Influence Of Athletic Status And Sex, Heather E. Hinton, Melanie D. Hernandez, Warren O. Forbes

International Journal of Exercise Science: Conference Proceedings

Removing the element of anticipation has previously shown to lead to worse performance on the Landing Error Scoring System (LESS) field test. It is unknown if sex or athletic status contributes to this phenomenon. PURPOSE: The purpose of this study was to investigate the influence of sex and athletic status on LESS performance with and without the element of anticipation. METHODS: Twenty-six participants performed five anticipated and five unanticipated trials of the LESS. For the anticipated LESS trials, participants were given specific instructions to perform a drop jump task, similar to the standard LESS assessment. Unanticipated LESS trials consisted of …

Effect Of Load Carriage On Grf, Lower Body Biomechanics, And Physiology, Oakley Slade, Megan Astle, Stetson Mcclellan, Brad Theel, Dallan Bye, Tyler Standifird, Shane Draper

International Journal of Exercise Science: Conference Proceedings

Rucking has gained in popularity over the past several years due to accessibility, affordability, functionality, and wide-ranging health benefits. Despite its popularity, there are several unknown biomechanical and physiological areas that remain underexplored. PURPOSE: Investigate the effects varying loads and inclines have on biomechanical and physiological factors. METHODS: Fifteen recreationally active individuals were randomly assigned to six different conditions on the treadmill. Treadmill conditions consisted of being unweighted or wearing a weighted pack while walking 1.5 m/s inclined (4.5 degrees), declined (-4.5), or flat. The weight of the ruck was relative to the participant's mass and heart rate (HR) in …

Stair Stepping And Peripheral Heating With Negative Pressure Improve Postprandial Glucose In Sleep Restricted Young Adults, Sabrina S. Stringfellow, Rachel Demonteverde, Jeff Moore, Jochen Kressler

International Journal of Exercise Science: Conference Proceedings

Sleep restriction (SR) impairs glycemic control, elevating the postprandial blood glucose (BG) response, an independent predictor of morbidity and mortality. Stair stepping and peripheral heating with negative pressure have been shown to acutely improve glycemic indices but have not been tested after SR. PURPOSE: To examine if stair stepping or peripheral heating with negative pressure improve postprandial BG after SR. We hypothesized 1-minute of brief, low-effort stair stepping and 60 min peripheral heating with negative pressure would improve postprandial glucose in sleep restricted (≤4 hours) young adults. METHODS: Participants (N=24; 22 (2) y; 13 female; 23.8 (5) kg/m2) performed a …

Isolation Of Mitochondrial Dna To Investigate Mitochondrial Genome Turnover In Skeletal Muscle, Kathryn Spry, Morgan Daniel, Clover D. Crenshaw, Robert Musci

International Journal of Exercise Science: Conference Proceedings

The quality of mitochondrial function is an essential part of cellular health. However, mutations occur within the cell during the metabolic processes of replication, repair, respiration and turnover. A build up of these mutations can cause mitochondrial dysfunction, which in turn leads to cell, tissue and eventually organismal dysfunction. Disease such as sarcopenia and cardiovascular disease are prime examples of the results of this process. Thus, better understanding mitochondrial DNA (mtDNA) turnover rates could contribute to a decreased risk of disease. PURPOSE: The purpose of this study was to 1) outline a procedure to isolate pure mtDNA from frozen …

The Physiological Responses To Cold-Water Immersion And Subsequent Rest Or Exercise, Yezica Ramirez, Aqueen Lenon, Shuto Tanaka, Matthew M. Minor, Ronnie Gonzalez, Ivan Farias-Martinez, Raffi Brodeyan, George H. Crocker

International Journal of Exercise Science: Conference Proceedings

Cold-water immersion (CWI) has increased in popularity – both as a recovery intervention after exercise and for possible chronic health benefits. In addition, a single CWI session evokes physiological responses that can be powerful tools to demonstrate core concepts of cardiorespiratory physiology. PURPOSE: The purpose of this study was to characterize the physiological responses to CWI and either light exercise or rest immediately afterwards. METHODS: Eight participants (29.4 ± 8.2 years old) were recruited from a graduate-level kinesiology course and paired based on sex (six men & two women) and body size (72.9 ± 11.2 kg). All participants …

Pilot Study: Impact Of Full-Body Muscle Contractions On Glucose Regulation By Activity Level, Charles Reyes, Erica Quillen, Christian Gonzalez, Rana Soussan, Janet Dionicio, Gabriela Oritz, Jermey Lohmann, Celeste Perez, Riley Garrett, Sebastian Castillo, Nathan Berio, Christian Ho, Anthony Pena, Anne Yang, Minhyuk Kwon

International Journal of Exercise Science: Conference Proceedings

Muscle contractions help regulate blood glucose by promoting uptake in the muscle cells. However, modern sedentary (low activity level) lifestyles significantly reduce opportunities for muscle contractions. PURPOSE: This study examined whether brief full-body muscle contractions could effectively alter glucose regulation with responses differing by activity level. METHODS: Three High-Active individuals (HA; 3100 ± 1002 MET-minute/week, 24 ± 5.7 years, 1 woman) and 3 Low-Active individuals (LA;129 ± 152 MET-minute/week, 19 ± 1.4 years, 1 woman) performed randomized and counterbalanced tasks involving brief full-body muscle contraction and non-contraction tasks. The contraction task consisted of 3 sets of 15s fully-body …

Relationships Between The Body Roundness Index, Bmi, And Waist Circumference With Visceral Adiposity As Assessed By The Inbody 770, Terrell Lee, Reed Muir, Elsie Call, Cole Affleck, Conner Harris, Abigail Larson

International Journal of Exercise Science: Conference Proceedings

Visceral adipose tissue (VAT) is strongly associated with metabolic disease risk; however, commonly used anthropometric measures, such as body mass index (BMI), waist circumference (WC), and percentage of body fat (%BF), may not accurately estimate VAT. The Body Roundness Index (BRI) is an anthropometric index that combines height and WC and relies on geometry and other statistically generated nonlinear models with the intent of estimating VAT. PURPOSE: As such, this study aimed to determine if the BRI is more highly correlated with VAT compared to BMI, WC, or %BF. METHODS: Height, weight, BMI, %BF, and visceral fat area …

Susceptibility To Eccentric Contractions-Induced Locomotor Muscle Injury In Cigarette Smoke-Exposed Mice, David Tran, Leonardo Nogueira

International Journal of Exercise Science: Conference Proceedings

Chronic exposure to tobacco cigarette smoke (CS) leads to pulmonary damage, inflammation, exercise intolerance, and skeletal muscle contractile and repair dysfunction, as our group has shown that CS exposure also delays muscle repair after eccentric contractions. This study investigated whether chronic CS exposure increases the susceptibility of locomotor muscles to injury from a session of eccentric contractions, as previous studies have shown that smokers have a greater risk of muscle injuries. Methods: Young adult (8 weeks old) wild-type mice (C57BL/6J, IACUC 25-071, n=24) were exposed to daily periods of CS or air (as controls) for eight consecutive weeks. After the …