Digital Commons Network^™

Association Of Germline Variants With Kras-Mutation Status In Colorectal Cancer, Nijole Pollock Tjader, Yin Cao, Et Al.

2020-Current year OA Pubs

Somatic mutations in KRAS are a common driver of colorectal cancer (CRC) and present at different frequencies by race, sex, tumor site, ethnicity, and genetic similarity. Inherited germline variants may influence tumor somatic mutation frequency by altering mutation or DNA repair processes or altering cellular, immunological and/or microenvironmental responses after a mutation. We hypothesized that the germline genetic background modifies somatic KRAS mutation frequency in CRC. To test this, we performed a genome-wide association study (GWAS) in 7071 individuals with CRC, using KRAS mutation status as the phenotype. Single-nucleotide variants were chosen for validation analyses based on P values from …

Reliability Of Existing Measures And Classification Systems For Trochlear Dysplasia, Sean R. Waldron, Nihar S. Shah, Matthew W. Veerkamp, Brendan A. Williams, John A. Schlechter, Lauren H. Redler, Matthew D. Ellington, Shital N. Parikh

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: Patellofemoral instability (PFI) is common in adolescent patients and can lead to a reduction in quality of life and function, as well as long-term arthritis. Treatment of PFI involves assessing and, at times, surgically correcting underlying anatomic abnormalities. Trochlear dysplasia is the most common anatomic risk factor present in PFI.

PURPOSE: To determine the interrater reliability of existing measures and classification systems for the assessment of trochlear dysplasia.

STUDY DESIGN: Cohort study (diagnosis); Level of evidence, 3.

METHODS: As part of the PRISM (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) patellar instability Research Interest Group (RIG) project, a …

Leo Ii...A Remembrance, The Flor-Ala

Documents

A special edition issue of The Flor-Ala in remembrance of Leo II.

New Honor For Leo Ii: May Be First In Nation, Cheri Shipper, Dr. J. R. Holladay, Dr. Wayne Cotton

Documents

This news release announces the exciting news that Leo II was selected as "Honorary ChairAnimal for National Pet Week" May 7-13 in the Shoals.

Tv Helps Leo Overcome Boredom, Karen Jackson

Documents

TV always makes people (and animals) happy!

*Article from The TimesDaily*

See The Lion At Una, Vacation Guide

Documents

A short write-up about the only African lion which serves as a school mascot-Leo II.

King Of The Jungle, Scott Burcham/Staff

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Leo II playing with his new toy pig on the eve of UNA's game against Texas A & M Kingsville in Florence.

Leo I Versus Leo Ii, Dr. Joe Wallace

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Personal account of Leo I versus Leo II written by Dr. Joe Wallace in Shoal Magazine.

Lion Talk: Vocabulary 101, Elise Cofield

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Information about the Lions Fund at the University of North Alabama in the Spring edition of the UNA Magazine.

Leo Ii's Passing Leaves Large Void Around Una Campus, Una Sports Information

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A fitting tribute to Leo II in the Lion's Roar.

The Story Of Leo The Lion, Joe Wallace

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This souvenir edition magazine details the relationship between author Joe Wallace and Leo I at UNA.

Watching Our Family Grow, Una Magazine

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A typical day for 10 months old Leo III and Una at the George H. Carroll Lion Habitat.

The Pride Of Una, Michelle Rupe Eubanks

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Fun facts about Leo III and Una.

Una's Leo Put To Sleep, Lori Allen Dendy

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Breaking the news that Leo I has passed away at 14 years old.

*Article from The TimesDaily. *

Leo Recalled With Fondness, Lori Allen Dendy

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Remembering Leo I.

*Article from The TimesDaily. *

College Mascot Dies, Montgomery Advertiser

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Write up from The Montgomery Advertiser about Leo I's passing.

Tv Time, Matt Mckean/Staff

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Blurb about the joy TV brings to Leo II in The TimesDaily.

Leo Ii Dies Of Heart Failure At Auburn, Office Of University Relations And Staff Reports

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News of Leo II's passing in The Flor-Ala.

Party Animal, Matt Mckean/Staff

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Leo II and kids from First United methodist Church daycare enjoy celebrating his birthday.

*Article from The TimesDaily*

Leo Ii...King Of Una, Steven Compton

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Shoals Magazine article on Leo II

Pressure Injury Prevention And Education, Maria T. Gonzales, Tammy Tyree, Kari Johnson, Crystelle Johnson

Creating Healthy Work Environments (CHWE)

Background: Increased age is a significant risk factor for hospital-acquired pressure injuries (HAPI) due to increased morbidities, decreased mobility, reduced nutrition, sensory impairments, reduced circulation, incontinence, and decreased immunity.

Purpose: Determine if focused education related to the Braden Scale (BS), pressure injuries (PI), and pressure injury prevention (PIP) will increase bedside staff knowledge of PI prevention and decrease HAPI incidence over three months.

Method: Pre/post-test design - Pre-intervention questionnaire, Educational Intervention, and Post-intervention questionnaire

Setting: 28-bed Orthopedic-Spinal Surgical Unit

Sample: Up to 38 nurses (RNs), four nursing supervisors, one director, and 14 patient care technicians (PCTs). Inclusion criteria: All full-time/part-time …

Powering Up Clinical Scholarship In Dental Journal Club On February 13, 2026, Evelyn Wang

HSLIC Faculty and Staff Instructional Resources

Instruction session for a dental journal club introducing common biases through critical appraisal of three article types: a systematic review (observer bias and blinding), a retrospective study (selection bias, information bias, and confounding), and a prospective pre‑post study (lack of a control group and residual confounding) in clinical research.

Burnout, Perceived Organizational Support, And Spirituality: In Msd Special Educators, Bianca Grider Fisher

Doctoral Dissertations and Projects

This quantitative correlational research study explored whether burnout (BO) is correlated with perceived organizational support (POS) in special education teachers (SETs) working with moderate to severe disabilities (MSDs) students during distress, and whether spirituality moderates the correlation. SETs working with MSD students face a heightened risk of BO, yet there is little literature exploring how organizational or spiritual resources help. Exploring these factors is necessary to strengthen SETs’ well-being. Guided by the Organizational Support Theory, theoretical frameworks on BO, Maslow's Theory on Spirituality and Hierarchy of Needs, the Cognitive Appraisal Approach, and biblical truths, this study explored how internal and …

Primary Membranoproliferative Glomerulonephritis: Natural History, Pathogenesis, And Treatment, Edward J. Filippone, John L. Farber

Division of Nephrology Faculty Papers

Primary membranoproliferative glomerulonephritis (MPGN) is an ultrarare disease characterized by immunofluorescence microscopy as either immune-complex mediated (IC-MPGN) or C3 glomerulopathy (C3), the latter subdivided by electron microscopy to C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). Both IC-MPGN and C3G typically have obvious C3 staining differentiating them from other causes of MPGN histology. Secondary causes must be excluded, including infections, autoimmune disease, and neoplasia. Clinical presentations are variable, including urinary sediment abnormalities, nephrotic syndrome, or a rapidly progressive course. The prognosis is unfavorable with about 50% reaching kidney failure by 10 years. Recurrence following transplantation is frequent, and allograft survival …

Examining The Influence Of High School Work-Based Learning Experiences On Post-Secondary Employment For Adults With Disabilities: A Case Study, Sarah Denhartog

Doctoral Dissertations and Projects

The purpose of this case study was to discover how work-based learning during high school was utilized to support successful post-secondary employment outcomes for young adults with high-incidence disabilities in a suburban area of a southeastern state. The theory guiding this study was Albert Bandura's social cognitive theory as it explains how observational learning, self-efficacy, self-regulation, and reciprocal determination affect the learning process. The central research question for this study was: How was work-based learning utilized to support successful post-secondary employment for young adults with high-incidence disabilities in a suburban area of a southeastern state. To answer the research questions, …

The Missed Education Of Mtss: A Phenomenological Study Of Cross-Cultural Counseling With African American Students, Whitney L. Towns

Doctoral Dissertations and Projects

The purpose of this qualitative study was to explore how secondary school counselors experience and implement cross-cultural counseling practices with African American students during the Multi-Tiered System of Supports (MTSS) process. African American students disproportionately face systemic barriers that influence their academic, behavioral, and social-emotional outcomes, and counselors are often underprepared to provide culturally responsive and trauma-informed care within the constraints of MTSS. Guided by Ecological Systems Theory, Intersectionality Theory, and the Trauma-Informed Practice Framework, this transcendental phenomenological study examined how counselors understood and carried out their roles across MTSS tiers while navigating issues of trust, culture, trauma, and equity. …

Volunteer Leaders Of Young Adult Ministries In Protestant Churches In The Midwest, Usa, Miriam S. Midzi

Doctoral Dissertations and Projects

Developing and retaining young adult ministry volunteers helps engage young adults and foster church growth. An article in Lifeway Research states that “Two-thirds (66%) of those who attended church regularly in high school dropped out for at least a year as a young adult” (Earls, 2019). Understanding the views and experiences of church ministry volunteers of this age group is essential as these young men and women are integral to reaching, discipling, and retaining them in the church. The purpose of this phenomenological study was to explore the lived experiences of volunteer leaders of young adult ministries in Midwest Protestant …

School Social Workers In Practice: A Transcendental Phenomenological Study On Understanding Role Navigation And Providing Mental Health Support In Educational Settings, Jennifer J. Bowers

Doctoral Dissertations and Projects

This transcendental phenomenological study examined the lived experiences of school social workers as they navigated their professional roles in supporting student mental health within educational settings. Grounded in Organizational Role Theory and Ecological Systems Theory, the study explored the meanings participants assigned to their roles, the challenges they encountered, and factors that supported or hindered their work. Purposeful sampling was used to recruit 11 licensed and unlicensed school social workers employed in the South Florida Tri-County area. Data were collected through in-depth, semi-structured interviews and analyzed using epoché, horizontalization, and thematic clustering. Findings revealed four interrelated themes: navigating roles and …

Childhood Emotional Abuse And Effects On Adult Behavioral Health, Motivation, And Resilience, Jonathan Pawson

Doctoral Dissertations and Projects

Childhood emotional abuse (CEA) is a frequently overlooked form of maltreatment that disrupts attachment formation and increases vulnerability to depression, anxiety, and other internalizing symptoms in adulthood. Because the harm is relational and often invisible, its long-term effects can persist without recognition. This study examined how CEA related to adult internalizing behaviors, resilience, and motivation, and whether resilience and motivation moderated these relationships. Attachment theory guided the framework for understanding how early emotional deprivation shapes later functioning.

A quantitative correlational design was used with 249 adults who completed the Childhood Trauma Questionnaire–Short Form (CTQ-SF), Beck Depression Inventory-II (BDI-II), Generalized Anxiety …

Autistic Mothers And Intimate Partner Violence (Ipv): An Intersectional Analysis Of Vulnerability And Systemic Barriers, Rachel D. Bailey

Doctoral Dissertations and Projects

The purpose of this qualitative phenomenological study was to explore how autistic mothers raising children with autism describe the support they received and the barriers they faced when leaving an IPV environment. The guiding theory for this study was Ecological Systems Theory, which was utilized to explore vulnerability to exploitation through aggressive abuse histories, normalization of violence, and the inability to see red flags in potential relationship partners. Intersectionality was utilized to examine how the interplay of abuse, autistic traits, race, socioeconomic states, and gender created a complex and challenging situation for autistic mothers affected by intimate partner violence. Eight …