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Assessment Of The Adequacy Of The Fast Healthcare Interoperability Resources (Fhir) Genomics Standard For The Representation Of Somatic Testing Reports., Robert H. Dolin, Bret S E Heale, James Patterson, Kevin Power, May Terry, Howard Anton, James Chen, Kashmira Sawant, Srikar Chamala Apr 2026

Assessment Of The Adequacy Of The Fast Healthcare Interoperability Resources (Fhir) Genomics Standard For The Representation Of Somatic Testing Reports., Robert H. Dolin, Bret S E Heale, James Patterson, Kevin Power, May Terry, Howard Anton, James Chen, Kashmira Sawant, Srikar Chamala

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: Enabling the unambiguous communication of cancer genetic testing results and the corresponding therapeutic implications of identified genetic variants is of major clinical importance. In this report, we assess the adequacy of the Health Level Seven Fast Healthcare Interoperability Resources (FHIR) Genomics Reporting Implementation Guide, version 3 (also known as "FHIR Genomics") for the structured communication of semantic objects typically appearing in real-world somatic testing reports.

MATERIALS AND METHODS: The GenomeX project team, part of the CodeX FHIR Accelerator, performed the following assessment: (1) gather a convenience sample of public somatic reports; (2) create a representative somatic report that includes …


Understanding Atomoxetine Exposure Variability In Children And Adolescents With Adhd Through Population Pharmacokinetics., Kevin V. Tobin, Addison M. Pritchett Ms, J Steven Leeder, Joga Gobburu, Allison Dunn Apr 2026

Understanding Atomoxetine Exposure Variability In Children And Adolescents With Adhd Through Population Pharmacokinetics., Kevin V. Tobin, Addison M. Pritchett Ms, J Steven Leeder, Joga Gobburu, Allison Dunn

Manuscripts, Articles, Book Chapters and Other Papers

Atomoxetine, a selective norepinephrine reuptake inhibitor, is a nonstimulant alternative to treat attention-deficit/hyperactivity disorder in children and adolescents. Atomoxetine exposure is highly variable due to cytochrome P450 polymorphism; however, the impact of these genetic variations has not been adequately characterized in the pediatric population. A population pharmacokinetic (PK) model was developed to evaluate steady-state atomoxetine exposures after oral administration in a large, heterogeneous population of children and adolescents with different metabolic phenotypes. Due to the highly variable and complex absorption between subjects and occasions, a two-stage approach was implemented, treating each participant/occasion as a separate individual. First, the individual atomoxetine …


Clostridioides Difficile Colonization And Infection In Pediatric Oncology And Stem Cell Transplant Patients, Daniel N. Willis, Erik R. Dubberke, Robert J. Hayashi, Phillip I. Tarr, David B. Haslam, Tiffany Hink, Jingqin Luo, Yu Tao, Amruta Padhye, Erin Hall, Gregory A. Storch Apr 2026

Clostridioides Difficile Colonization And Infection In Pediatric Oncology And Stem Cell Transplant Patients, Daniel N. Willis, Erik R. Dubberke, Robert J. Hayashi, Phillip I. Tarr, David B. Haslam, Tiffany Hink, Jingqin Luo, Yu Tao, Amruta Padhye, Erin Hall, Gregory A. Storch

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Pediatric oncology and hematopoietic stem cell transplant (HSCT) patients have elevated risk for Clostridioides difficile infection (CDI), which can prolong hospitalization and delay chemotherapy. Colonization is an important prelude to symptomatic CDI. We sought to characterize colonization status in these patients.

METHODS: We retrospectively studied 276 stools longitudinally collected over 34 months from 32 HSCT and 12 oncology patients treated at a single tertiary center. Specimens were cultured for C difficile and compared by whole genome sequencing. The fecal microbiome was characterized by 16S rRNA gene sequencing.

RESULTS: Baseline cultures were positive in 16 (50%) HSCT patients and 2 …


Cd8 Trm-Like T Cells Expressing Perforin And Ifn-Γ Define A Pediatric Activated T-Cell Acute Liver Failure Endotype., Tamir Diamond, Catherine A. Chapin, Caroline J. Diorio, Sarah Mccuaig, Michelle Lau, Niansheng Chu, Nora M. Gibson, Portia A. Kreiger, Simon Horslen, Kathleen M. Loomes, Anna M. Banc-Husu, Jaime Chu, M Kyle Jensen, Daniel H. Leung, Amrita Narang, Beth A. Carter, Scott Elisofon, Ryan T. Fischer, Steven J. Lobritto, Mike Leonis, Anna L. Peters, Norberto Rodriguez-Baez, Rene Romero, Philip Rosenthal, David Rudnick, James Squires, Shikha Sundaram, Kyla M. Tolliver, Pamela Valentino, Valerie Durkalski, Estella M. Alonso, Edward M. Behrens Apr 2026

Cd8 Trm-Like T Cells Expressing Perforin And Ifn-Γ Define A Pediatric Activated T-Cell Acute Liver Failure Endotype., Tamir Diamond, Catherine A. Chapin, Caroline J. Diorio, Sarah Mccuaig, Michelle Lau, Niansheng Chu, Nora M. Gibson, Portia A. Kreiger, Simon Horslen, Kathleen M. Loomes, Anna M. Banc-Husu, Jaime Chu, M Kyle Jensen, Daniel H. Leung, Amrita Narang, Beth A. Carter, Scott Elisofon, Ryan T. Fischer, Steven J. Lobritto, Mike Leonis, Anna L. Peters, Norberto Rodriguez-Baez, Rene Romero, Philip Rosenthal, David Rudnick, James Squires, Shikha Sundaram, Kyla M. Tolliver, Pamela Valentino, Valerie Durkalski, Estella M. Alonso, Edward M. Behrens

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Activated T-cell pediatric acute liver failure (TC-PALF) is the most common cause of non-acetaminophen PALF, with poor transplant-free survival. Livers in TC-PALF are infiltrated by effector cytotoxic T lymphocytes with markers of tissue-resident memory function (CD8 Trm) and an interferon gamma (IFNγ) transcriptional signature. The PALF-Immune Response Network (PALF-IRN) and the prospective TReatment for ImmUne-Mediated PathopHysiology (TRIUMPH) clinical trial (NCT04862221) aim to characterize the TC-PALF immune pathology and utility of T-cell directed therapy to improve transplant-free survival.

METHODS: TRIUMPH patients with TC-PALF were compared with healthy children and disease controls utilizing multiparameter flow cytometry and 3' single-cell RNA sequencing …


Ten Tips On How To Optimize Nutrition In Children With Chronic Kidney Disease Or On Dialysis., Nonnie Polderman, Vanessa Shaw, Caroline E. Anderson, An Desloovere, Louise Mcalister, Christina L. Nelms, Fabio Paglialonga, Pearl Pugh, Leila Qizalbash, Evelien Snauwaert, José Renken-Terhaerdt, Jetta Tuokkola, Larry A. Greenbaum, Rukshana Shroff Apr 2026

Ten Tips On How To Optimize Nutrition In Children With Chronic Kidney Disease Or On Dialysis., Nonnie Polderman, Vanessa Shaw, Caroline E. Anderson, An Desloovere, Louise Mcalister, Christina L. Nelms, Fabio Paglialonga, Pearl Pugh, Leila Qizalbash, Evelien Snauwaert, José Renken-Terhaerdt, Jetta Tuokkola, Larry A. Greenbaum, Rukshana Shroff

Manuscripts, Articles, Book Chapters and Other Papers

Optimal nutrition is central to growth and development in all children, and is particularly relevant in those with chronic illnesses. This document provides 10 practical, evidence-informed tips on the assessment and management of the nutritional prescription in children with chronic kidney disease (CKD) and those receiving dialysis. The 10 tips synthesize work of the Paediatric Renal Nutrition Taskforce, an international team of pediatric renal dietitians and pediatric nephrologists who develop clinical practice recommendations for the nutritional management of children with kidney diseases. We describe a comprehensive, three-dimensional nutritional assessment (anthropometry, dietary intake, biochemical markers) and regular monitoring tailored to age, …


Factors Associated With Child Protective Services Referrals In Young Children With Isolated Skull Fractures., Karli Breeden-Carino, Joanne N. Wood, Cindy W. Christian, Tagrid M. Ruiz-Maldonado, Daniel M. Lindberg, Angela Bachim, Lori Frasier, Terra N. Frazier, Nancy S. Harper, Sara E. Kruczek, Farah Brink, Jennifer E. Wolford, Jan Leonard, M Katherine Henry Apr 2026

Factors Associated With Child Protective Services Referrals In Young Children With Isolated Skull Fractures., Karli Breeden-Carino, Joanne N. Wood, Cindy W. Christian, Tagrid M. Ruiz-Maldonado, Daniel M. Lindberg, Angela Bachim, Lori Frasier, Terra N. Frazier, Nancy S. Harper, Sara E. Kruczek, Farah Brink, Jennifer E. Wolford, Jan Leonard, M Katherine Henry

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: Many young children with isolated skull fractures are referred to child protective services (CPS) despite being assessed to have a low likelihood of abuse. We sought to identify factors associated with CPS referrals in this population and to quantify hospital-level variation.

METHODS: We performed a multicenter retrospective cross-sectional study of children < 2 years with skull fractures with or without a small underlying intracranial hemorrhage (ICH) and no additional injuries undergoing a child abuse pediatrics (CAP) subspecialty evaluation. We explored associations between demographic factors, clinical characteristics, psychosocial risk factors, and hospital site with CPS referral status. We performed multivariable logistic regression, adjusting for transfer status and all significant covariates from unadjusted analyses. We utilized marginal standardization to calculate the estimated probability of CPS referrals at each site, adjusting for all factors in the final model.

RESULTS: Of 528 children, 303 (57.4%) were referred to CPS, with 86.5% referred before CAP consultation. In multivariable logistic regression, presence of psychosocial risk factors (OR 4.00; 95% CI 2.25, 7.11), in-person CAP consult (OR 3.93; 1.61, 9.62), inflicted or no trauma history provided (OR 6.15; 3.30, 11.45), …


Confessions In Cases Of Child Physical Abuse-A Capnet Study., Margaret R. Russell, Antoinette L. Laskey, Henry T. Puls, Suzanne P. Starling, Joanne N. Wood, Daniel M. Lindberg, Nancy S. Harper, Caitlin R. Mcnamara, Angela W. Bachim, Farah W. Brink, Lori D. Frasier, James Anderst, Porcia Vaughn, Kristine A. Campbell Apr 2026

Confessions In Cases Of Child Physical Abuse-A Capnet Study., Margaret R. Russell, Antoinette L. Laskey, Henry T. Puls, Suzanne P. Starling, Joanne N. Wood, Daniel M. Lindberg, Nancy S. Harper, Caitlin R. Mcnamara, Angela W. Bachim, Farah W. Brink, Lori D. Frasier, James Anderst, Porcia Vaughn, Kristine A. Campbell

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: Prior research on confessions of physical abuse (PA) has explored mechanisms of injury. Little is known about conditions supporting a confession of abuse or how confessions may influence case outcomes.

METHODS: This cross-sectional study of suspected PA in children aged < 10 years at 10 centers participating in CAPNET, a multicenter child PA research network, included children with in-person Child Abuse Pediatrics (CAP) consultations between February 2021 and December 2022 and excluded children without injury. Our focus was a confession of inflicted injury known to the CAP during clinical involvement. We compared child and clinical characteristics, out-of-home (OOH) placements, and arrests between cases with and without confessions. Multivariable models using generalized estimating equations (GEE) produced adjusted predicted probabilities (APP) clustering by CAPNET site.

RESULTS: Confessions were known to CAPs in 115/4297 (2.7%) cases, with significant site variability. In a multivariable GEE model, confessions were more likely in cases with injuries with high specificity for abuse (APP 6.0% vs 1.6%, P < .001), near-fatality (APP 5.6% vs 2.3%, P < .001), and older children (APP 4.8% vs 2.5%, P = .025). OOH placements and arrests were more common in cases with confessions. CAP awareness of confessions, OOH placements, and arrests did not follow racial or ethnic patterns seen in the US child welfare system. Lower socioeconomic status was associated with OOH placements and arrests but not with CAP awareness of confessions.

CONCLUSIONS: Our findings highlight differences in case characteristics and outcomes where a confession is known to the CAP and raise questions about …


Exploitive Adolescent Labor And Labor Trafficking: Clinical Perspectives For Adolescent Healthcare Providers., Romina Barral, Michele A. Kelley, Abigail English, Marissa Raymond-Flesch, Tonya Chaffee, Veronica Svetaz, Tamera Coyne-Beasley, Nuray Kanbur Apr 2026

Exploitive Adolescent Labor And Labor Trafficking: Clinical Perspectives For Adolescent Healthcare Providers., Romina Barral, Michele A. Kelley, Abigail English, Marissa Raymond-Flesch, Tonya Chaffee, Veronica Svetaz, Tamera Coyne-Beasley, Nuray Kanbur

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.


De Novo Rras2 Pathogenic Variant In A Fetus With Bilateral Radial Ray And Multisystem Anomalies., Nicole R. Legro, Lylach Haizler-Cohen, William Genthe, Victoria Greenberg Apr 2026

De Novo Rras2 Pathogenic Variant In A Fetus With Bilateral Radial Ray And Multisystem Anomalies., Nicole R. Legro, Lylach Haizler-Cohen, William Genthe, Victoria Greenberg

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.


Protocol For Non-Invasive Assessment Of Skeletal Muscle Structure And Function In Adolescents With Single Ventricle Heart Disease: A Cross-Sectional, Case-Control Study., Tyler A. Fick, Trent J. Herda, Emily Cramer, David A. White, Daniel Forsha Apr 2026

Protocol For Non-Invasive Assessment Of Skeletal Muscle Structure And Function In Adolescents With Single Ventricle Heart Disease: A Cross-Sectional, Case-Control Study., Tyler A. Fick, Trent J. Herda, Emily Cramer, David A. White, Daniel Forsha

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Congenital heart disease (CHD) is the most common congenital malformation, and the most severe type, single ventricle (SV) heart disease, requires the Fontan surgical palliation. Fontan palliation minimizes hypoxemia and volume overload by separating systemic and pulmonary circulations, resulting in the absence of a sub-pulmonary pump. Skeletal muscle health may have a greater relative contribution to overall functional capacity of those with SV physiology, via the skeletal muscle (SkM) pump mechanism and oxidative capacity. The purpose of this study is to comprehensively evaluate multiple domains of SkM in this population compared to those with normal cardiac anatomy.

METHODS: Forty …


Evaluating Human Rod Photoreceptor Function Using Pixelwise Intensity-Based Optoretinography, Gao Yang, Mina Gaffney, Robert F. Cooper Apr 2026

Evaluating Human Rod Photoreceptor Function Using Pixelwise Intensity-Based Optoretinography, Gao Yang, Mina Gaffney, Robert F. Cooper

Biomedical Engineering Faculty Research and Publications

Purpose: More than 50 inherited retinal diseases are known, with rod photoreceptor functional loss serving as an early indicator in nearly half of them. The “optoretinogram” is a relatively new assay that detects optical changes in cells in response to stimuli. This tool has excellent potential for providing insights into the earliest functional changes of rod photoreceptors, with the potential to assist in the early detection, monitoring, and treatment of retinal diseases.

Methods: In this work, we obtained intensity-based optoretinograms (iORGs) from rod photoreceptors using an adaptive optics scanning laser ophthalmoscope. We explore the necessity of both individual rod identification …


Herding Cats: The Behavioral Foundations Of Successful Multi-Sector Partnerships, Paul B. Olsen Apr 2026

Herding Cats: The Behavioral Foundations Of Successful Multi-Sector Partnerships, Paul B. Olsen

School of Public Service Theses & Dissertations

Multi-sector partnerships (MSPs) are problem-solving groups composed of government agencies, nonprofit organizations, private firms, community groups, and individuals. These partnerships have often struggled to achieve consistent success, with performance rates estimated at 30%–50%, largely because MSPs are tailored to the specific interests, resources, and implementation contexts of the constellation of stakeholders involved in each project. This situation raised important questions regarding how MSP performance can be predicted and whether the likelihood of success can be enhanced during the early planning stages of partnership formation.

Social value orientation (SVO) is a behavioral public administration theory that may help explain variation in …


Early Parenting Stress And Later Abuse Risk: Dyadic Mediation By Maternal And Paternal Negative Attributions, Jewelian N. Fairchild Apr 2026

Early Parenting Stress And Later Abuse Risk: Dyadic Mediation By Maternal And Paternal Negative Attributions, Jewelian N. Fairchild

Psychology Theses & Dissertations

Parenting stress and negative parental attributions are key contributors to child abuse risk. Early parenting stress may increase a parent’s risk of negatively appraising their child’s behaviors, which, in turn, may influence their likelihood of harsh or abusive parenting. Grounded in Social Information Processing (SIP) Theory, the present study explored how these processes evolve over time and differ between mothers and fathers. Specifically, this study investigated whether parental negative attributions mediated the relationship between early parenting stress and later abuse risk. A sample of 203 first-time mothers and 151 of their male partners were recruited prenatally as part of a …


Polyhydroxybutyrate (Phb) From Biofloc Systems Enhances The Growth And Immune Performance Of Genetically Improved Farmed Tilapia, Menaga Meenakshisundaram, Jimmy B. Mboya, Felix Sugantham Apr 2026

Polyhydroxybutyrate (Phb) From Biofloc Systems Enhances The Growth And Immune Performance Of Genetically Improved Farmed Tilapia, Menaga Meenakshisundaram, Jimmy B. Mboya, Felix Sugantham

All Peer-Reviewed Publications

This study characterised polyhydroxybutyrate (PHB)-producing bacteria from the culture water of genetically improved farmed tilapia (GIFT) in biofloc ponds and investigated the influence of PHB on the growth and immune performance of GIFT. Out of 40 bacterial isolates, Bacillus infantis, Exiguobacterium profundum, Bacillus subtilis, Bacillus megaterium, Klebsiella pneumoniae and Enterococcus hirae showed positive results for PHB against fluorescent stains. The PHB yield in the range of 5%–95.45% (w/w) was recorded, with the highest from K. pneumoniae (95.45% w/w). The experimental treatments included a basal diet as a control (C), a basal diet with PHB (5 g kg−1) from …


Spider Mite Response, Agronomic Performance, And Stability Of A Urochloa Spp. Diversity Panel Under Field Conditions, Adrian Mating’I Kimani, David Kariuki Muruu, Paula Espitia-Buitrago, Sylvia Henga, Catherine Muui, Frank Chidawanyika, Rosa Noemi Jauregui Apr 2026

Spider Mite Response, Agronomic Performance, And Stability Of A Urochloa Spp. Diversity Panel Under Field Conditions, Adrian Mating’I Kimani, David Kariuki Muruu, Paula Espitia-Buitrago, Sylvia Henga, Catherine Muui, Frank Chidawanyika, Rosa Noemi Jauregui

All Peer-Reviewed Publications

Spider mites (Oligonychus trichardti) are emerging as a major constraint to Urochloa forage productivity in East Africa; however, knowledge of genotypic variation and tolerance remains limited. Herein, 55 Urochloa genotypes were evaluated under field-infested and non-infested conditions across two seasons using an alpha-lattice design. Agronomic and physiological traits, including plant height (PH), tiller number (TN), the Normalized Difference Vegetation Index (NDVI), total dry weight (TDW), and mite damage indices (visual severity index (VSI) and stress tolerance index (STI)) were assessed. Infestation reduced biomass by 22.4% on average, with reductions of up to 45% in susceptible genotypes. Significant genotypic variation was …


Agronomic Practices For Climate-Resilient Okra Production In Agroecological Systems: A Review, Samuel Mathu Ndungu, Lokeshwar Kesamreddy, Mathieu A.T. Ayenan, Stephen Othim, Siyabusa Mkuhlani, Yu Hsiang Liu, Amha Besufkad, Wubetu Bihon Legesse, Eric C. Legba, Judith Honfoga, Lukas Pawera Apr 2026

Agronomic Practices For Climate-Resilient Okra Production In Agroecological Systems: A Review, Samuel Mathu Ndungu, Lokeshwar Kesamreddy, Mathieu A.T. Ayenan, Stephen Othim, Siyabusa Mkuhlani, Yu Hsiang Liu, Amha Besufkad, Wubetu Bihon Legesse, Eric C. Legba, Judith Honfoga, Lukas Pawera

All Peer-Reviewed Publications

Okra is increasingly recognized as a climate-resilient crop within diversified agroecological systems; however, an integrated synthesis of its biophysical, agronomic, and socioeconomic dimensions is lacking. This review consolidates the current knowledge on okra physiology, production ecology, and value chains, with a focus on climate resilience under heat, drought, salinity, pest, and disease pressures. Evidence across regions demonstrates that agroecological practices such as crop diversification, mulching, conservation tillage, integrated pest management, and the use of organic and biological inputs consistently improve soil health, stabilize yields under climatic stress, and reduce dependence on external inputs, although with trade-offs in labor demand and …


Dipl 6310 Research Methods For Policy Analysis, Prashant Hosur Suhas Ph.D. Apr 2026

Dipl 6310 Research Methods For Policy Analysis, Prashant Hosur Suhas Ph.D.

Diplomacy Syllabi

This class is an introduction to political science international relations research methodology. My main goal is to teach you the basics of creating and consuming research in the social sciences. The course will lead you through conceptualization and theory construction, the derivation of testable hypotheses, and a variety of methodologies that may be used to evaluate these hypotheses. We will discuss causal inference, observation and measurement, and other issues encompassing both qualitative and quantitative research methods. We will discuss the way in which academic articles in the social sciences are written, and how they should be read.

This course includes …


Postmarketing Safety Of Bimekizumab For Hidradenitis Suppurativa: An Early Pharmacovigilance Analysis Using The United States Food And Drug Administration Adverse Event Reporting System, Simona A. Alomary, Nicole J. Baker, Temitayo Ogunleye, Susan C. Taylor Apr 2026

Postmarketing Safety Of Bimekizumab For Hidradenitis Suppurativa: An Early Pharmacovigilance Analysis Using The United States Food And Drug Administration Adverse Event Reporting System, Simona A. Alomary, Nicole J. Baker, Temitayo Ogunleye, Susan C. Taylor

Student Papers, Posters & Projects

No abstract provided.


A Novel Nudt16-Based Strategy For Producing Defined Phosphoribosylated Substrates To Study Nampt Antiviral Activity Against Hsv-1, Steph Nivaggioli Apr 2026

A Novel Nudt16-Based Strategy For Producing Defined Phosphoribosylated Substrates To Study Nampt Antiviral Activity Against Hsv-1, Steph Nivaggioli

Bioengineering Master's Theses

Herpes simplex virus (HSV) is a highly prevalent human pathogen whose symptoms are characterized by the formation of painful blisters and ulcers. There are two major families of HSV: HSV-1, primarily transmitted through oral contact, and HSV-2, predominantly spread through sexual contact. Periodic reactivation of the virus enables continued transmission and recurrent disease. Antiviral drugs that suppress viral replication are available to the public; however, no curative therapy exists.

Recent studies suggest that HSV reprograms host cellular metabolism to support its replication. Notably, this includes the manipulation of nicotinamide adenine dinucleotide (NAD⁺) homeostasis. Under standard physiological conditions, NAD⁺ is consumed …


Quality Of Antenatal And Delivery Care And Postnatal Care Use: A Multi-Country Observational Study Of 400,000 Births, Jan E. Cooper, Hwa-Young Lee, Katherine Wright, Prashant Jaryan, Margaret E. Kruk Apr 2026

Quality Of Antenatal And Delivery Care And Postnatal Care Use: A Multi-Country Observational Study Of 400,000 Births, Jan E. Cooper, Hwa-Young Lee, Katherine Wright, Prashant Jaryan, Margaret E. Kruk

2020-Current year OA Pubs

BACKGROUND: Postnatal care (PNC) plays a crucial role in averting newborn mortality, yet its use remains low, particularly in regions with the highest mortality. While demographic and social determinants of PNC use have been well studied and have informed current strategies focused on changing care-seeking behaviors, the stagnating decline in neonatal mortality highlights the need for upstream and system-wide approaches to increase PNC uptake. Limited evidence exists to guide system-level reforms; therefore, we investigated whether health systems that ensure high-quality perinatal care are associated with increased use of PNC.

METHODS AND FINDINGS: We performed a cross-sectional observational study using Demographic …


Detailed Single-Cell Mapping Of The Transcriptional Response To A Virus Infection Driven By Copy-Back Viral Genomes, Yanling Yang, Emna Achouri, Munyaradzi Tambo, Carolina B. López Apr 2026

Detailed Single-Cell Mapping Of The Transcriptional Response To A Virus Infection Driven By Copy-Back Viral Genomes, Yanling Yang, Emna Achouri, Munyaradzi Tambo, Carolina B. López

2020-Current year OA Pubs

The antiviral response to several clinically significant viruses, including respiratory syncytial virus and parainfluenza virus, is driven by copy-back viral genomes (cbVGs) generated during virus replication. However, the broader impact of cbVGs on the functional states of host cells remains undefined. Here, we developed a single-cell RNA-sequencing and computational framework to map cbVG-driven host responses during Sendai virus infection. Unsupervised profiling identified distinct transcriptional states throughout the course of infection, highlighting a shift from early antiviral signaling to later inflammatory and remodeling programs. Stratifying infected cells by cbVG status demonstrated that cbVG-positive cells initiate interferon and chemokine programs, which later …


The Woah Global Wildlife Health Collaborating Centre Network (Woah-Wildnet): A Coordinated And Transformative Approach To Global Wildlife Health Challenges, David T.S. Hayman, Steve Unwin, Kelly Bateman, Casey Barton Behravesh, Charlotte Berg, Jemma Bergfeld, Cristina Casalone, Claire Cayol, Erin Davis, Sunday Ekesi, Johan Esterhuizen, Merid Getahun, Federica Giorda, Keith Hamilton, Damien O. Joly, Christa Kühn, Jean Claude Manuguerra, Daniel Masiga, Anita Michel, Paolo Mulatti, Misheck Mulumba, Annah Njui, Richard Paley, Antonio Fernández, Sascha Knauf, David P. Tchouassi, Youming Wang, Nathalie Vachiery, Jandouwe Villinger Apr 2026

The Woah Global Wildlife Health Collaborating Centre Network (Woah-Wildnet): A Coordinated And Transformative Approach To Global Wildlife Health Challenges, David T.S. Hayman, Steve Unwin, Kelly Bateman, Casey Barton Behravesh, Charlotte Berg, Jemma Bergfeld, Cristina Casalone, Claire Cayol, Erin Davis, Sunday Ekesi, Johan Esterhuizen, Merid Getahun, Federica Giorda, Keith Hamilton, Damien O. Joly, Christa Kühn, Jean Claude Manuguerra, Daniel Masiga, Anita Michel, Paolo Mulatti, Misheck Mulumba, Annah Njui, Richard Paley, Antonio Fernández, Sascha Knauf, David P. Tchouassi, Youming Wang, Nathalie Vachiery, Jandouwe Villinger

All Peer-Reviewed Publications

Introduction Wildlife health is integral to functioning, complex ecosystems [1], directly and indirectly influencing the health of people, animals, plants, and the environment [2–4]. Healthy wildlife populations are essential for ecosystem services and are at the heart of the One Health approach [3,4], which aims to sustainably balance and optimize the health of people, animals, and ecosystems through multisectoral and transdisciplinary collaboration [5]. Despite its importance, wildlife health initiatives often operate in silos, limiting capacity to address transboundary threats such as emerging diseases, pollution, and environmental changes. Anthropogenic changes, including habitat loss, degradation, fragmentation, and unsustainable harvesting, exacerbate wildlife health …


Relational Practices Underpinning Person-Centred Care In Long-Term Residential Care Settings., Gary Hodge, Sam Ebden, Susie Pearce Apr 2026

Relational Practices Underpinning Person-Centred Care In Long-Term Residential Care Settings., Gary Hodge, Sam Ebden, Susie Pearce

School of Nursing and Midwifery

Recent figures indicate that there are just over 441,000 people living in long-term residential care homes across the United Kingdom (UK) (Berg, 2025), of which 70% are living with dementia or a severe cognitive impairment (Alzheimer’s Society, 2024). The percentage of people living in permanent residential aged care with dementia in Australia is slightly lower (54%) but still represents most residents and is rising (AIHW, 2025; Dementia Australia, 2025).This article is based on the findings and reflections of a qualitative multiple-case study exploring person-centred care across seven residential care homes in the United Kingdom (UK; Hodge et al., 2023). Findings …


X-Linked Cancer-Associated Polypeptide (Xcp) From Lncrna1456 Modulates Phf8 Histone Demethylase Activity To Regulate The Epigenome, Gene Expression, And Cellular Pathways In Breast Cancer, Shrikanth S. Gadad, Cristel V. Camacho, Xuan Gong, Micah Thornton, Venkat S. Malladi, Anusha Nagari, Aishwarya Sundaresan, Tulip Nandu, Sneh Koul, Yan Peng, W. Lee Kraus Apr 2026

X-Linked Cancer-Associated Polypeptide (Xcp) From Lncrna1456 Modulates Phf8 Histone Demethylase Activity To Regulate The Epigenome, Gene Expression, And Cellular Pathways In Breast Cancer, Shrikanth S. Gadad, Cristel V. Camacho, Xuan Gong, Micah Thornton, Venkat S. Malladi, Anusha Nagari, Aishwarya Sundaresan, Tulip Nandu, Sneh Koul, Yan Peng, W. Lee Kraus

School of Medicine Publications

Recent studies have demonstrated that a subset of long “noncoding” RNAs (lncRNAs) produce functional polypeptides and proteins. In this study, we discovered a 132 amino acid protein in human breast cancer cells named XCP (X-linked Cancer-associated Polypeptide), which is encoded by lncRNA1456 (a.k.a. RHOXF1P3), a transcript previously thought to be noncoding. lncRNA1456 is a pancreas- and testis-specific RNA whose gene is located on chromosome X. We found that the expression of lncRNA1456 and XCP is highly upregulated in the luminal A, luminal B, and HER2 molecular subtypes of breast cancer. XCP modulates both estrogen-dependent and estrogen-independent growth of breast …


Platelet Rich Plasma Injection Treatment Outcomes In Patellar Tendinopathy, Hunter M. Butler, Aamir Ahmad Apr 2026

Platelet Rich Plasma Injection Treatment Outcomes In Patellar Tendinopathy, Hunter M. Butler, Aamir Ahmad

School of Medicine Publications

Background: Platelet rich plasma (PRP) refers to the processed product of autologous peripheral blood with a concentration of platelets higher than baseline. This product has garnered interest for 30 years as a potential method of regenerative medicine. PRP injections have shown to be an effective treatment for patellar tendinopathy. However, some concerns remain with regards to empiric treatment of tendinopathy with PRP injections.

Objective: This article aims to investigate the outcomes of platelet rich plasma injections in patients with patellar tendonitis.

Methods: A systematic literature search was conducted using the University of Texas Rio Grande Valley (UTRGV) online database. The …


Variation In Corneal Biomechanical Properties Following Continuous Cross-Linking Treatment, Chenhao Zhao, Xinyu Yao, Yewei Zhao, Hongjiang Wu, Xuanya Tong, Daniela Oehring, Lan Yang, Xiaofei Zhou, Ying Li, Yanjie Shen, Yufeng Ye, Shihao Chen, Jia Qu, Qinmei Wang, Ahmed Elsheikh, Fangjun Bao Apr 2026

Variation In Corneal Biomechanical Properties Following Continuous Cross-Linking Treatment, Chenhao Zhao, Xinyu Yao, Yewei Zhao, Hongjiang Wu, Xuanya Tong, Daniela Oehring, Lan Yang, Xiaofei Zhou, Ying Li, Yanjie Shen, Yufeng Ye, Shihao Chen, Jia Qu, Qinmei Wang, Ahmed Elsheikh, Fangjun Bao

School of Health Professions

Background: This retrospective study aimed to evaluate the efficacy of transepithelial accelerated corneal cross-linking (transEpi ACXL) when applied separately or combined with phototherapeutic keratectomy (transPTK ACXL) in keratoconic eyes using biomechanical parameters. Methods: The study included eyes with progressive keratoconus treated with either continuous transEpi ACXL or transPTK ACXL with 6 months follow-up. The following parameters were assessed preoperatively and 6 months postoperatively: biomechanically corrected intraocular pressure (bIOP), maximum and mean keratometry (K max and K m), minimum and central corneal thickness (MCT and CCT), corneal coma, best-corrected visual acuity (BCVA), deformation amplitude ratio at 2 mm nasal/temporal (DAR2), …


Internal Public Relations Influence On Organizational Citizenship Behaviors: Integrating Social Identity Perspectives In Organizational Contexts, Daewook Kim Mar 2026

Internal Public Relations Influence On Organizational Citizenship Behaviors: Integrating Social Identity Perspectives In Organizational Contexts, Daewook Kim

Asia Marketing Journal

This study examined how internal public relations encourages employees to participate in organizational citizenship behaviors. Using a national survey of employees (N = 339), we tested a conceptual model that proposed linkages among dialogic internal communication, organizational social capital, communal relationships, and organizational citizenship behaviors. The results suggest dialogic internal communication can enhance organizational social capital and encourage internal publics to participate in organizational citizenship behaviors. Additionally, organizational social capital mediated the effects of dialogic internal communication on communal relationships and organizational citizenship behaviors. The findings highlight a critical connection between public relations and social identity perspectives within organizational …


Temporal Dynamics Of Online Shopping: A Multidimensional Clustering Approach For Optimizing Time-Specific Advertising Strategies, Hye Ra Oh, Yunjae Cheong Mar 2026

Temporal Dynamics Of Online Shopping: A Multidimensional Clustering Approach For Optimizing Time-Specific Advertising Strategies, Hye Ra Oh, Yunjae Cheong

Asia Marketing Journal

This study clusters consumers according to their hourly online shopping consumption patterns and develops optimized advertising strategies that can be practically applied by companies. Specifically, we considered multidimensional variables related to consumers, including demographic characteristics, shopping frequency, information search and content consumption characteristics, and lifestyle traits. We explored consumer types by comparing various clustering algorithms and applying the optimal clustering method for each time period. The analysis results show significant differences in payment amounts according to payment time periods. Regarding consumer types, consumption tendencies are distinctly differentiated by payment time periods, with each cluster showing different characteristics. This study is …


Does Ai-Driven Empathy Work In Healthcare Marketing? The Impact Of Cognitive And Affective Empathy In Chatbots And The Moderating Role Of Illness Type, Jee Won Kim, Yeonsoo Kim, Jino Chung Mar 2026

Does Ai-Driven Empathy Work In Healthcare Marketing? The Impact Of Cognitive And Affective Empathy In Chatbots And The Moderating Role Of Illness Type, Jee Won Kim, Yeonsoo Kim, Jino Chung

Asia Marketing Journal

Recognizing the growing potential of AI-generated chatbots in healthcare and healthcare marketing, this study investigates how different types of chatbot-expressed empathy influence user responses in stigmatized versus non-stigmatized health contexts. Perceived authenticity is introduced as a key mediator. Drawing on Mind Perception Theory, a 3 (empathy: none, cognitive, affective) × 2 (illness type: stigmatized, non-stigmatized) online experiment was conducted. The findings show that affective empathy reduced perceived authenticity, which subsequently decreased user satisfaction, perceived understanding, reuse intention, and follow intention. These indirect effects varied by illness type: in stigmatized contexts, non-empathetic communication was viewed most favorably, whereas in non-stigmatized contexts, …


Stock Assessment Of The Dusky Spine Foot Siganus Luridus From The Gulf Of Aqaba, Egypt, Using A Length-Based Bayesian Biomass (Lbb) Method, Azza A. El-Ganainy, Abdel-Kader M. Hassan, Hussein A. El-Naggar, Hassan M. M. Khalaf-Allah, Ahmed M. El-Sadek Mar 2026

Stock Assessment Of The Dusky Spine Foot Siganus Luridus From The Gulf Of Aqaba, Egypt, Using A Length-Based Bayesian Biomass (Lbb) Method, Azza A. El-Ganainy, Abdel-Kader M. Hassan, Hussein A. El-Naggar, Hassan M. M. Khalaf-Allah, Ahmed M. El-Sadek

Blue Economy

The dusky spinefoot, Siganus luridus (Rüppel, 1829), stands as one of the most economically significant herbivorous species inhabiting the coral reefs of the Gulf of Aqaba, Egypt. Despite its prominence, our understanding of its biology and population structure remains limited. Thus, this study marks the first attempt to shed light on the demographic structure and stock assessment of S. luridus in the Aqaba Gulf. Over the span of January to December 2018, a total of 649 specimens were meticulously collected on a monthly basis from three landing sites (Nuwebaa, Dahab, and Abu Galum) within the Gulf of Aqaba, primarily utilizing …