Digital Commons Network^™

Draft 2025 Butte Priority Soils Operable Unit Residential Metals Abatement Program Construction Completion Report, Abby Peltomaa

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Final Quarterly Operations And Maintenance Report: Butte Treatment Lagoon System – Third Quarter 2025, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Final Quarterly Operations And Maintenance Report Butte Treatment Lagoon System – First Quarter 2025, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Implications Of The Midyear Departure Of Residence Directors In Housing And Residential Life, Chelsea Titus

Electronic Theses and Dissertations

High attrition rates among entry-level student affairs professionals have been documented for decades, yet little research has examined the implications of midyear departures within housing and residential life. Residence directors serve as live-in professionals responsible for crisis response, student conduct, staff supervision, and community development. When a midyear departure occurs, the disruption extends beyond the vacancy and affects supervisors, colleagues, and residential communities. The problem addressed in this study was the organizational and supervisory impact of midyear residence director departures. The purpose of this qualitative narrative inquiry was to examine the factors contributing to midyear departures and to explore how …

Reducing Humpty Dumpty Syndrome In Pediatric Inpatients, Jeanene Burns

Electronic Theses and Dissertations

The Doctor of Nursing Practice project examined pediatric inpatient falls. The healthcare agency involved in the project identified concerns regarding pediatric inpatient falls. Data were collected on pediatric inpatient falls that occurred on two nursing units at this agency based on the Generalized Risk Assessment for Pediatric Inpatient Falls and the Humpty Dumpty Falls Prevention Scale. Results from the project indicated marginal statistical significance, with approximately a 60% reduction in falls after the implementation of the Humpty Dumpty Falls Prevention Scale. A recommendation for future research is a comparison of the two pediatric fall risk assessment tools after the Humpty …

Exploring The Way Up: Career Paths, Challenges, And Resilience Among Women Leaders In Higher Education, Angela M. Brown

Electronic Theses and Dissertations

Women represent the majority of students and faculty in higher education students in higher education in the United States, yet they remain underrepresented in executive leadership positions. Women pursuing these roles encounter unique challenges, and institutions have increasingly recognized the value of mentoring and sponsoring women who aspire to leadership. Guided by Kumar’s CR8 resilience theory, this qualitative descriptive study explored how women leaders in higher education in the United States describe their career pathways to leadership, the challenges they encounter, and the impact of mentoring/sponsoring in developing their resilience for career progression. Semistructured interviews were conducted with 11 women …

Bridging The Divide: Exploring Stigma And Enhancing Belonging For Online Faculty In Higher Education, Stephanie L. Wanamaker

Electronic Theses and Dissertations

Online faculty in higher education experience stigma and negative perceptions regarding online education in academia. Despite the rapid growth and success of online education, negative perceptions and stigma have not evolved at the same pace as the success of online institutions. Many online faculty members frequently experience skepticism, criticism, and marginalization from their residential counterparts within their academic communities. As a result of these experiences, online faculty are experiencing a reduced level of belonging, contributing to increased levels of burnout, poor satisfaction, and struggles with professional identity. Despite these experiences, little is known about the problem or how online faculty …

How Can Learning Management Systems Positively Impact Student Engagement In Online Courses?, Jerald P. Wilson

Electronic Theses and Dissertations

The topic of this dissertation is learning management systems, specifically Canvas. Research has proven that student engagement is a strong factor in student achievement in both online and inperson courses. The COVID-19 pandemic highlighted a deficit in instructors’ ability to acquire and maintain student engagement in online courses. This study details why this problem exists and how instructors have successfully addressed it in higher-level online courses. The primary purpose of this qualitative descriptive study was to examine how learning management systems, specifically Canvas, can increase student engagement in online courses in higher education. Qualitative research was the chosen paradigm for …

African American Male Dual Enrollment Graduates Perceptions Of The Transition To The 4-Year University, Kendra L. Harrison

Electronic Theses and Dissertations

The purpose of this qualitative exploratory case study was to explore how African American men who earned an associate degree from dual enrollment programs in Texas perceive the transition to a 4-year university to pursue a bachelor’s degree. The 4S model of Schlossberg’s transition theory was the conceptual framework that undergirded the study. Purposive sampling was used to recruit 20 participants. The researcher collected and triangulated data using a questionnaire and semistructured interviews and analyzed it using six-step thematic analysis. Results revealed competence and confidence from dual enrollment program resulted in a smooth transition to college, participants’ African American male …

Two-Year Outcomes Following Delandistrogene Moxeparvovec Treatment In Ambulatory Patients With Duchenne Muscular Dystrophy: Phase 3 Embark Trial, Jerry R Mendell, Craig M Zaidman, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Delandistrogene moxeparvovec is a recombinant adeno-associated virus rhesus isolate serotype 74 vector-based gene therapy that addresses the absence of functional dystrophin in Duchenne muscular dystrophy (DMD). EMBARK is a phase 3, two-part, crossover, randomized, placebo-controlled trial assessing the safety and efficacy of delandistrogene moxeparvovec (single intravenous dose 1.33 × 10

METHODS: As a result of the crossover study design, 2-year functional outcomes of patients receiving delandistrogene moxeparvovec in part 1 of EMBARK were compared, by pre-specified analysis, with a matched propensity score-weighted external control (EC).

RESULTS: At 2 years, EMBARK patients showed statistically significant benefit versus the EC cohort …

Tfeb Degradation Is Regulated By An Ikk/Β-Trcp2 Phosphorylation-Ubiquitination Cascade, Yan Xiong, Jaiprakash Sharma, Meggie N Young, Wen Xiong, Ali Jazayeri, Karl F Poncha, Ma Xenia G Ilagan, Qing Wang, Bei Gao, Hui Zheng, Nicolas L Young, Marco Sardiello

2020-Current year OA Pubs

Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and cellular clearance pathways. TFEB activity is tightly controlled by multiple post-translational mechanisms, but the exact molecular mechanism controlling its stability has remained elusive. Here, we identify the IκB kinase (IKK) complex as a key regulator of TFEB protein stability through a phosphorylation-ubiquitination cascade. A high-content kinase inhibitor screen reveals that IKK inhibition increases TFEB protein levels, and genetic ablation of IKK components increases TFEB stability, upregulates lysosomal genes, and enhances lysosomal biogenesis and degradative capacity. Mechanistically, we show that IKK phosphorylates TFEB on a cluster of serine residues …

When Birth Control Turns Biliary: A Rare Case Of Profound Hyperbilirubinemia From Oral Contraceptives, Taiwo Ajani, Aura Calderon, Jose J. Loayza Pintado, Nayiri Derian, Catherine Matos, Ivan Mogollon, Andres Suarez Parraga

School of Medicine Publications

Oral contraceptives (OCs) are extensively utilized and generally considered safe (reference); nonetheless, infrequent hepatobiliary complications such as cholestasis and hyperbilirubinemia have been documented, particularly among individuals with a genetic predisposition. We present a case involving a 19-year-old female who exhibited significant conjugated hyperbilirubinemia shortly after the commencement of OC therapy. Comprehensive investigations ruled out alternative causes, and the findings from liver biopsy, in conjunction with the clinical context, indicated an estrogen-induced cholestatic injury, likely revealing an underlying Dubin–Johnson syndrome. This case underscores the critical necessity of acknowledging hepatic adverse effects associated with estrogen as well as the influence of genetic …

Predictors Of Total Hip Arthroplasty Among Patients With Chronic Comorbidities: A Multivariate Analysis Of A Medically Underserved Region, Blake C. Martin, Manoj Peiris

School of Medicine Publications

Background

THA is a common orthopedic procedure that is expected to increase in the coming years. Obesity and osteoarthritis are major factors that increase the risk of individuals requiring THA. The Rio Grande Valley (RGV) is a distinctive health professional shortage area with high rates of obesity, arthritis, and diabetes. This study aims to examine the relationship between chronic medical conditions and the need for THA in this at-risk, medically underserved population.

Methods

This investigation employed a retrospective chart review encompassing patient records from January 1, 2018, through January 1, 2025, using the University of Texas Rio Grande Valley electronic …

Trends In Meningioma-Related Mortality Among U.S. Adults: A Cdc Wonder Analysis From 2000 To 2023, Tirath Patel, Rai Muhammad Umar Khan, Fatima Hussain, Meer Murtaza, Muhammad Shayan Tariq, Abuzar Khan, Sara Aleem, Maryam Athar, Sharoz Shahid, Nikhilesh Anand

School of Medicine Publications

Background: Meningiomas are the most common primary intracranial tumors in the United States, comprising nearly 41% of central nervous system tumors. While the majority are benign, atypical (World Health Organization Grade II) and malignant (Grade III) subtypes are clinically significant due to their aggressive biology, higher recurrence, and increased mortality risk. Despite their burden, national mortality trends and demographic disparities in meningioma-related deaths remain underexplored.

Methods: We conducted a population-based analysis of meningioma-related mortality among U.S. adults aged ≥65 years from 1999 to 2023 using the centers for disease control and prevention (CDC) wide-ranging online data for epidemiologic research (WONDER) …

Staying Power: A Case Study Of Teacher Retention In A Rural District, Amanda F. Mclellan, Amanda F. Mclellan

Electronic Theses and Dissertations

Teacher attrition continues to be a significant challenge in K-12 education, particularly in rural school districts where limited resources and geographic isolation can intensify staffing instability. While much research has focused on teacher attrition, little research examines why tenured teachers choose to remain in rural districts. The purpose of this qualitative, single-case study was to examine the experiences and insights of tenured teachers regarding their decision to continue teaching in a small, rural Texas school district. Guided by Mason and Matas’s fourcapital framework for teacher retention, this study examined how human, social, structural, and positive psychological capital influenced teachers’ decisions …

Implementing Hypertension Guidelines Into Clinical Practice, Misti Michele Mays

Electronic Theses and Dissertations

Hypertension is a complex chronic disease process, and it is essential to educate the patient on the disease process, as well as on all aspects of self-management. It is essential that providers choose an evidence-based guideline by which they will manage their hypertensive patients. In addition, providers must schedule regular follow-up appointments with their patients, along with a wide variety of other multifactorial components in regard to the management of patients diagnosed with hypertension. In addition, providers have a responsibility to stay informed on new approaches to blood pressure management by reviewing the professional literature on a regular basis. Much …

Leading The Charge: A Qualitative Descriptive Study Exploring How Public Middle School Principals Perceive And Enact Their Role As Advocates For School-Based Mental Health, Tanya Irby Tucker

Electronic Theses and Dissertations

Adolescent mental health concerns have increased significantly during the middle school years, requiring school leaders to expand their role in supporting students’ social, emotional, and psychological well-being. Although schools are uniquely positioned to deliver comprehensive mental health services, how public middle school principals perceive and enact their role as advocates for school-based mental health services remains underexplored. The purpose of this qualitative descriptive study was to explore how public middle school principals perceive and enact their role as advocates for school-based mental health services. Guided by social cognitive theory (SCT), this study examined how personal beliefs, behavioral practices, and environmental …

Influence Of Restorative Justice Practices On Student Behavior, Shawn N. Clemons

Electronic Theses and Dissertations

The purpose of this qualitative exploratory case study was to explore how teachers in culturally diverse suburban U.S. elementary schools perceive the implementation of restorative justice practices as an influence on student behavior. The researcher collected data through questionnaires and semistructured interviews of 14 elementary teachers currently employed in a suburban elementary school who actively use restorative justice with students. Findings from the study indicated the restorative justice practices contribute positively to school culture by prioritizing relationship building, structured conflict resolution, and inclusive practices. The findings from this study can be used with teachers, administrators, district support, and school board …

Propaganda Ai: An Analysis Of Semantic Divergence In Large Language Models, Nay Myat Min, Long H. Pham, Yige Li, Jun Sun

Research Collection School Of Computing and Information Systems

Large language models (LLMs) can exhibit concept-conditioned semantic divergence: common high-level cues (e.g., ideologies, public figures) elicit unusually uniform, stance-like responses that evade token-trigger audits. This behavior falls in a blind spot of current safety evaluations, yet carries major societal stakes, as such concept cues can steer content exposure at scale. We formalize this phenomenon and present RAVEN (Response Anomaly Vigilance), a black-box audit that flags cases where a model is simultaneously highly certain and atypical among peers by coupling semantic entropy over paraphrastic samples with cross-model disagreement. In a controlled LoRA fine-tuning study, we implant a concept-conditioned stance using …

Reasoning On Time-Series For Financial Technical Analysis, Kelvin J. L. Koa, Jan Chen, Yunshan Ma, Huanhuan Zheng, Tat-Seng Chua

Research Collection School Of Computing and Information Systems

While Large Language Models have been used to produce interpretable stock forecasts, they mainly focus on analyzing textual reports but not historical price data, also known as Technical Analysis. This task is challenging as it switches between domains: the stock price inputs and outputs lie in the time-series domain, while the reasoning step should be in natural language. In this work, we introduce Verbal Technical Analysis (VTA), a novel framework that combine verbal and latent reasoning to produce stock time-series forecasts that are both accurate and interpretable. To reason over time-series, we convert stock price data into textual annotations and …

Neighborhood Physical Disinvestment And Incident Diabetes Between Visits 1 And 2 Of The Hispanic Community Health Study/Study Of Latinos (Hchs/Sol)., Cara M. Smith, Elizabeth W. Spalt, Linda C. Gallo, Jordan A. Carlson, Matthew Allison, Bharat Thyagarajan, Earle C. Chambers, Amber Pirzada, Martha Daviglus, Christina Cordero, Qibin Qi, Elena Austin, Amanda M. Fretts, India Ornelas, Robert Kaplan, Joel D. Kaufman, Stephen J. Mooney

Manuscripts, Articles, Book Chapters and Other Papers

Neighborhood-scale environmental factors, including disinvestment in infrastructure, may impact cardiometabolic disease risk. To our knowledge, no prior studies have investigated the association between neighborhood disinvestment and incident diabetes. We used a virtual street audit of Google Street View Imagery to generate a neighborhood disinvestment score for participants' residential addresses in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). An item response theory model was fit to indicators (litter, graffiti, under-maintained buildings, bars on windows, and abandoned buildings) to form a scale measuring a latent level of disinvestment. Ordinary kriging was used to estimate levels for each residential address within the …

A Comparative Analysis Estimating Aspergillosis And Histoplasmosis Encounters Among Inpatients In The United States Using Multi-Regional Electronic Health Record And National Discharge Data, 2014-2020., Brittany L. Morgan Bustamante, Juliana G E Bartels, Aidan Lee, Natalie J. Kane, Rose Reynolds, Theodore C. White, Mark A. Hoffman, Jennifer Head, Justin V. Remais

Manuscripts, Articles, Book Chapters and Other Papers

Fungal diseases are an emerging public health threat, yet their epidemiology remains poorly understood due to limited surveillance. Electronic health record (EHR) datasets offer opportunities for studying fungal diseases, but their national representativeness is unclear. We compared inpatient encounters for aspergillosis and histoplasmosis between Oracle EHR Real World Data (OERWD) and the Healthcare Cost and Utilization Project National Inpatient Sample (HCUP NIS), a nationally representative discharge-derived database. We analyzed inpatient encounters from both databases and applied calibration weights to OERWD to improve alignment with national benchmarks. Relative differences (RDs) in encounter counts were compared using Wald tests. Survey-weighted quasibinomial models …

Electromyography, Prosthetic Properties, And Running Biomechanics In Recreationally Active Persons With Lower Extremity Amputation, Paige M. Agnew

Rehabilitation Sciences Theses & Dissertations

Lower extremity loss affects nearly 150,000 individuals in the United States yearly yielding extreme health care costs annually. Typically, prosthetic devices are prescribed for 5-8 years despite known changes to an individual’s gait as time progresses. Patients can expect to undergo approximately 8-12 weeks of gait retraining to improve their comfort and efficiency. Biomechanical changes occur when running with a specific running prosthetic including considerable biomechanical and neuromuscular interlimb asymmetries and alterations in loading patterns. The purpose of this dissertation was to investigate the biomechanical demands for lower extremity prosthesis users during running. The first study synthesized peer reviewed evidence …

Dna Methylation Of Slc6a4 And Nr3c1 In Term And Preterm Infants: A Pilot Study Of Nicu-Associated Stress, Kathryn J. Malin, Yvette P. Conley, Aleigha Barry, Rosemary White-Traut

College of Nursing Faculty Research and Publications

Background: Preterm infants requiring prolonged hospitalization in the neonatal intensive care unit (NICU) are often exposed to early-life stress, which may contribute to long-term health consequences. Epigenetic markers, particularly DNA methylation (DNAm) of stress-related genes such as SLC6A4 and NR3C1, have been identified as potential biomarkers of early-life stress. Limited research has compared DNAm patterns between term and preterm infants or examined associations between NICU-related stress and DNAm in preterm populations. Objectives: This pilot study aimed to (1) compare DNAm patterns between preterm and term infants, (2) examine relationships between NICU-related stress and DNAm alterations in preterm infants, and …

Secondary Dual Language And Immersion Content Teachers And Their Instructional Materials, Curtis Larsen

School of Education and Leadership Student Capstone Theses and Dissertations

Secondary dual language and immersion (DLI) teachers who teach content courses, such as social studies or science, balance two central responsibilities: meeting content-area standards and supporting students’ language development (Cammarata & Tedick, 2012). Managing these responsibilities presents challenges when preparing and using instructional materials in languages other than English (Moate, 2014; Morton, 2013; Skinnari, 2020; Sun, 2017). While existing research shows that DLI teachers expend enormous energy seeking and preparing instructional materials for their content-area classes (Mathieu, 2022), little is known about the factors that guide this work or how well existing materials meet teachers’ needs. This dissertation sought to …

What Works In Martial Education: How The Experience Of Martial Educators Defines Living Muay Thai’S Place In An Evolving Martial Community, Justin Markus

School of Education and Leadership Student Capstone Theses and Dissertations

Martial education, particularly Muay Thai, rarely offers formal educator training, and what does exists is rarely backed by research. Educators frequently develop in isolation, within communities lacking evidence-based frameworks. Some practitioners may find their way to pedagogical knowledge, but most do not. Living Muay Thai (LMT) was founded in 2020 to address these gaps. This qualitative phenomenological study evaluated LMT’s impact on martial educators after its first five years (April 2020-July 2025) and identified 11 areas for future development. Seven Muay Thai educators participated in semi-structured interviews and a focus group. An emergent phenomenological analysis generated findings; a reflexive thematic …

Development And Acceptability Of A Patient Decision Aid For People With Degenerative Cervical Myelopathy: An International Mixed-Methods Study, Andrew R. Gamble, David B. Anderson, Marnee J. Mckay, Benjamin M. Davies, Sophie Macpherson, James Van Gelder, Tammy Hoffmann, Kirsten Mccaffery, Samuel X. Stevens, Carlo Ammendolia, Rohil V. Chauhan, Carl M. Zipser, Timothy F. Boerger, Lindsay A. Tetreault, Michael G. Fehlings, Elanor Dustan, Carolyn Nugent, Helen Holmgren, Andreas K. Demetriades, Justin M. Lantz, Rana Dhillon, Chris G. Maher, Joshua R. Zadro

Biomedical Engineering Faculty Research and Publications

Objectives To develop and user-test a patient decision aid for people diagnosed with degenerative cervical myelopathy and who are considering surgery.

Design Mixed-methods study describing the development of a patient decision aid.

Setting A draft decision aid was developed by a multidisciplinary steering group (including study authors with degenerative cervical myelopathy, health professionals and researchers) informed by the best available evidence, authorship consensus and existing patient decision aids.

Participants Patient-participants and health professional-participants who manage people with degenerative cervical myelopathy were recruited through social media and the steering group’s research and practice network. Quantitative questionnaires were used to gather baseline …

Resilience Factors For Physical Activity After Completion Of Intensive Interdisciplinary Pain Treatment: A Qualitative Analysis., William R. Black, Lora L. Black, Jennifer Christofferson, Liesbet Goubert, Cara M. Hoffart, Dustin Wallace

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: This study explored potential resilience factors that facilitate engagement in physical activity (PA) among adolescents with chronic musculoskeletal pain after completing intensive interdisciplinary pain treatment.

METHODS: Ten adolescents aged 13 to 17 years with a history of chronic musculoskeletal pain from a mid-western pediatric hospital in the United States participated in this qualitative study. Participants provided demographic information and completed semistructured virtual interviews. The interviews focused on their pain experiences, resilience, and engagement in PA. Transcripts were analyzed using primarily directed content analysis based on a pain resilience framework.

RESULTS: Participants highlighted several key resilience factors that influenced their …

Cardiac Medication Use In Action For Duchenne Muscular Dystrophy Cardiomyopathy., Carol A. Wittlieb-Weber, Brian Birnbaum, Chesney D. Castleberry, Tyler W. Cunningham, Paul Esteso, Katheryn E. Gambetta, Emily A. Hayes, Daphne T. Hsu, Beth D. Kaufman, Benjamin Kroslowitz, Ashwin K. Lal, Angela Lorts, Hugo Martinez, Deepa Mokshagundam, Deipanjan Nandi, John J. Parent, Frank Raucci, Nelia Soares, Jonathan H. Soslow, Renata Shih, Svetlana Shugh, Chet R. Villa, Sarah J. Wilkens, Bethany L. Wisotzkey, Jennifer Conway

Manuscripts, Articles, Book Chapters and Other Papers

This study seeks to understand cardiac medication use in a large cohort of males with Duchenne Muscular Dystrophy (DMD) followed prospectively with focus on current practices and adherence to consensus directed medical therapy (CDMT). DMD patients have been enrolled in the Advanced Cardiac Therapies Improving Outcomes Network (ACTION) Dystrophinopathy Registry since 2021. Cardiac medication use was analyzed at enrollment and most recent follow-up. CDMT was defined as concurrent use of angiotensin-converting-enzyme inhibitor (ACEi)/angiotensin II receptor blocker (ARB) /angiotensin receptor-neprilysin inhibitor (ARNI) plus beta-blocker (BB) plus mineralocorticoid receptor antagonist (MRA). Two hundred sixty-five males with DMD (median age 17.5 (IQR 14.5-21.5) …

Proximal And Distal Factors Associated With Obesity In Childhood: An Exploratory Structural Equation Model., Joseph A. Skelton, Erinn T. Rhodes, Sarah Hampl, Ihuoma Eneli, Edward H. Ip, Sit Study Research Group

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Obesity in childhood is complex; structural equation modeling (SEM) offers an approach to ascertain complicated relationships between weight and proximal (health behaviors, child health) and distal (family/household, community) variables. The objective of the study was to use SEM to map the influence of different etiological clusters on obesity in childhood.

METHODS: Secondary analysis of baseline data from patients and parents enrolled in a multi-site study of pediatric weight management was conducted. The primary outcome was weight status (utilizing percentage above the 95th percentile BMI, %95BMI). SEM was used to evaluate the influences of variables proximal and distal to child …