Digital Commons Network^™

Development And Internal Validation Of A Pretransplant Biomarker Panel For Mortality Prediction Following Liver Transplant, Guergana G Panayotova, Sopio Simonishvili, Lianhua Jin, Duc T Nguyen, Edward A Graviss, Yong Qin, Anastasia Xynogala, Tumininu Ayorinde, Laurie J Minze, Alexander Lemenze, Krupa R Mysore, Julie M Corkrean, Linda W Moore, Flavio Paterno, Ashish Saharia, Constance M Mobley, Arpit Amin, Mark J Hobeika, Xian C Li, Paul J Gaglio, R Mark Ghobrial, James V Guarrera, Keri E Lunsford

Faculty, Staff and Students Publications

Importance: Current pretransplant clinical scoring systems fail to accurately estimate post-liver transplant (LT) survival, making recipient selection challenging. Persistent immune dysfunction contributes to early LT recipient mortality but is not captured by existing models.

Objective: To identify plasma biomarkers of pretransplant immune dysfunction and to develop a biomarker-based pre-LT risk stratification tool to predict post-LT mortality.

Design, setting, and participants: Prospective biomarker analysis of consecutively enrolled adult LT recipients was conducted. Healthy controls were included for baseline comparison. Patients undergoing LT at Houston Methodist Hospital (October 1, 2013, to December 31, 2017) and Rutgers/University Hospital (January 1, 2019, to March …

Long-Term Outcomes Of Left Bundle-Branch Pacing Vs Biventricular Pacing In Heart Failure: The Heartsync-Lbbp Randomized Clinical Trial, Xueying Chen, Xi Liu, Ruogu Li, Zhongkai Wang, Yixiu Liang, Lei Zhang, Wei Wang, Jin Bai, Jingfeng Wang, Shengmei Qin, Weiwei Zhang, Tianbao Yao, Dong Huang, Ting Chen, Xianxian Zhao, Dening Liao, Jingbo Li, Jialiang Mao, Mihail G Chelu, Yangang Su, Kenneth A Ellenbogen, Junbo Ge

Faculty, Staff and Students Publications

Importance: Left bundle-branch pacing (LBBP) has been proposed as an alternative to biventricular pacing (BiVP) for patients with heart failure with left bundle-branch block (LBBB). However, robust clinical evidence from randomized clinical trials is lacking.

Objective: To evaluate the long-term clinical outcomes of LBBP and BiVP.

Design, setting, and participants: This multicenter, prospective, randomized clinical trial enrolled 200 patients at 6 centers in China with a left ventricular ejection fraction (LVEF) of 35% or less and LBBB from October 2020 to March 2022. This study was took place from October 2020 to September 2024. These data were analyzed September 2024 …

Phenome-Wide Analysis Of Copy Number Variants In 470,727 Uk Biobank Genomes, Xueqing Zoe Zou, Fengyuan Hu, Haiyi Lou, Oliver S Burren, Xiaoyin Li, Karyn Megy, Eleanor Wheeler, Qiang Wu, Santosh S Atanur, Marcin Karpinski, Douglas Loesch, Zammy Fairhurst-Hunter, Sri V V Deevi, Erin Oerton, Sean Wen, Xiao Jiang, Cecilia Salvoro, Jonathan Mitchell, Abhishek Nag, Ben Hollis, Amanda O'Neill, Jen Harrow, Stewart Macarthur, Sebastian Wasilewski, Sean O'Dell, Lifeng Tian, Katherine R Smith, Guillermo Del Angel, Margarete Fabre, Ryan S Dhindsa, Quanli Wang, Slavé Petrovski, Keren Carss

Duncan NRI Faculty and Staff Publications

Copy number variants (CNVs) are key drivers of human diversity and disease risk1. Here we evaluate the role of CNVs across a broad range of human phenotypes and diseases by analysing CNVs from 470,727 UK Biobank whole-genome sequences and conducting a variant- and gene-level phenome-wide association study (PheWAS) with 2,941 plasma protein abundance measurements, 13,336 binary clinical phenotypes and 1,911 quantitative traits. Proteomic analyses validated functional associations of CNVs with nearby genes (cis-protein quantitative trait loci; cis-pQTLs)—with deletions and duplications typically associated with reduced and increased protein levels, respectively—and uncovered previously unknown protein–protein interactions …

Leadless Pacing And The Emerging Era Of Combined Procedures In Adult Congenital Heart Disease, Srikant Das, Brock A Karolcik, Taylor S Howard

Faculty, Staff and Students Publications

No abstract provided.

Methodological Progress Note: Logic Models, Molly J Horstman, Kyler M Godwin

Faculty and Staff Publications

Logic models are an accessible tool to organize the planning, management, and evaluation of programs across healthcare disciplines. This methodological progress note describes the five standard components of a logic model (Inputs, Activities, Outputs, Outcomes, and Impact) and provides guidance for developing a logic model. Logic models offer a visual representation of the work and theory of a program and should be created with input from all interested parties. Logic models are living tools that need to be revised as programs evolve and new information becomes available.

Tfeb Degradation Is Regulated By An Ikk/Β-Trcp2 Phosphorylation-Ubiquitination Cascade, Yan Xiong, Jaiprakash Sharma, Meggie N Young, Wen Xiong, Ali Jazayeri, Karl F Poncha, Ma Xenia G Ilagan, Qing Wang, Bei Gao, Hui Zheng, Nicolas L Young, Marco Sardiello

Center on Aging Staff Publications

Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and cellular clearance pathways. TFEB activity is tightly controlled by multiple post-translational mechanisms, but the exact molecular mechanism controlling its stability has remained elusive. Here, we identify the IκB kinase (IKK) complex as a key regulator of TFEB protein stability through a phosphorylation-ubiquitination cascade. A high-content kinase inhibitor screen reveals that IKK inhibition increases TFEB protein levels, and genetic ablation of IKK components increases TFEB stability, upregulates lysosomal genes, and enhances lysosomal biogenesis and degradative capacity. Mechanistically, we show that IKK phosphorylates TFEB on a cluster of serine residues …

Copley Connects | Fall 2025/Spring 2026, University Of San Diego

Copley Connects Library Newsletter

Message From the Dean | 3
Writing in Visual Form: noé olivas’ Neon Art Installation | 4
San Diego’s French Connection | 6
Instagrammable Moments: A Librarian’s Reflections on San Diego and USD | 8
Copley Celebrates the 3rd Annual Filipino American History Month Event | 10
Banned Books Week | 10
Copley Library Hosts the Inaugural Student Success Symposium | 11
Veterans/Armistice Day: Veterans for Peace Visit Copley Library | 11
UDEM and USD Sign Sister Libraries MOU | 12
Cruising Through History: The Lowrider Stamp Unveiling | 13
Copley Reads | 14
Cultural Mosaic: Celebrating Asian American and …

University Of San Diego Magazine Spring 2026, Publications Department

University of San Diego Magazine (1992- )

Beauty, Goodness and Truth; Dear Toreros; Around Alcalá Park; Roads Less Traveled; Faith in Action; Asking Better Questions in an Age of Easy Answers; Shaping the Next Generation of Science Leaders; At the Edge of It All; Global Perspectives; Torero Athletics; Toreros Making Waves; In Memoriam; Leading With Love

From Theory To Practice: Splint Fabrication Through Occupational Therapy Video Library, Caitlyn Mccaughey

Capstone Projects

This doctoral capstone experience (DCE) highlights the need for educational resources on occupational therapy splint fabrication by producing a comprehensive video library to aid skill acquisition among students and new graduates. This project involved developing 21 tutorial videos featuring detailed, step-by-step demonstrations designed to accommodate visual, auditory, and kinesthetic learning styles amongst individuals. A literature review emphasized the growing popularity of video-based education and the lack of accessible, high-quality splinting resources, with a needs assessment revealing low confidence levels among occupational therapy students due to limited educational support. Through collaboration and integration of evidence-based practices, this project successfully produced an …

Draft Final 2025 Bpsou Subdrain Data Summary Report (Dsr), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Giving Meaningful Effect To Victims’ Rights: The Canadian Victims Bill Of Rights As Quasi-Constitutional Legislation, Benjamin Perrin

All Faculty Publications

This research paper is the first detailed examination of the quasi-constitutional status of the Canadian Victims Bill of Rights ("CVBR") and the implications for its interpretation and application. It aims to provide a doctrinal account of this extraordinary legal recognition and to serve as a resource for scholars, judges, lawyers, and other justice system participants to ensure that the CVBR is interpreted and applied consistently with its aim of serving as a catalyst for transformative change to how the criminal justice system has historically treated victims.

Bridging The Gap: A Trauma-Informed Approach To Real-Time Counselor Support Training At Kesem, Elizabeth Fallon

Capstone Projects

This capstone project involved the development and implementation of a trauma-informed care training program for college-aged counselors within Kesem, a nonprofit organization supporting children affected by a parent or caregiver’s cancer. The project addressed gaps in existing counselor training related to recognizing and responding to trauma in real time. The literature identified increased risk for psychosocial challenges in this population, including anxiety, depression, as well as the importance of peer support, safe environments, and developmentally appropriate communication.

The training program included different modules on trauma, grief, and child development, as well as interactive role-play scenarios tailored to different age groups …

Creation And Implementation Of Nature And Sensory Based Therapy Programming To Support The Health And Well-Being Of Catholic Dominican Sisters, Sydney Payne

Capstone Projects

As the older generation ages, diseases such as dementia can cause sensory processing systems to be less efficient. When they become less efficient, it can create confusion and undermine one’s sense of safety (Champagne, 2018 pg 29-30). Engaging in sensory experiences provides support for these deficits while fostering participation in everyday life activities (Champagne, 2018 pg 30). This capstone project included a sensory garden (nature-based therapy) and associated multi-sensory activities. This was done through creation of nature and sensory-based programming, implementation of this programming one-on-one with sisters, two group sensory, dementia-friendly activities, and formation of a sustainability binder. Occupational therapy …

Implementation Of A Cardio Drumming Program To Promote Health And Wellbeing In Community-Dwelling Older Adults, Amanda Moyer

Capstone Projects

This doctoral capstone experience focused on implementation of a cardio drumming program at the Ecumenical Senior Center (ESC), a day center for older adults, in Kalamazoo Michigan. Cardio drumming is a unique way of exercise that combines drumming to upbeat music with an exercise ball, laundry basket, and drumsticks. Cardio drumming is low impact and can be adapted to many different abilities. This form of exercise can be done in a seated or standing position. The program began once a week for 30 minutes but soon increased to two times a week for 35 minutes and lasted 9 weeks due …

The Bronco Well: An Educational Podcast For Pediatric Caregivers’ Wellbeing & Quality Of Life, Molly Veldheer

Capstone Projects

Pediatric caregivers of children with increased and complex physical, cognitive, and emotional needs are an often-overlooked population. Though their children may be involved in many essential services including occupational therapy, the needs of these caregivers largely go unmet. Occupational therapists are equipped to provide valuable care and education to the entire family and not just their pediatric clients. In efforts to fill the unmet needs, this occupational therapy-based podcast was created as resource for pediatric caregivers about pediatric caregivers. The development of this capstone considered the time, energy, and financial strains that are often placed on pediatric caregivers and determined …

Creative Art-Based Program To Address Body Image In Cancer Survivors And Caregivers, Tisa Lightfoot

Capstone Projects

This doctoral capstone experience (DCE) explored the role of occupational therapy in promoting the use of creative art-based interventions to address body image in cancer survivors and caregivers. Within the oncology population, body image concerns are a prevalent psychosocial factor that affects survivors’ self-perception, emotional well-being, and occupational engagement in their daily lives. To address this gap, a six-week program was developed to promote art as a meaningful occupation to support the psychosocial well-being related to body image in cancer survivors and caregivers. Additional initiatives of the program included resource development and integration of education on current literature on the …

Social Skill Program Development: Social Thinking Curriculum, Anna Holman

Capstone Projects

This capstone project examined the implementation of the Social Thinking It: Tweens and Teens curriculum to support adolescent social participation within a group-based setting. Social participation is a core domain of occupational therapy; however, many adolescents experience challenges with communication, emotional regulation, and peer relationships. This project addressed a gap in structured, evidence-based social skills programming at the capstone site. Primary objectives included implementing the Social Thinking curriculum, facilitating weekly group sessions, evaluating participant engagement, and skill development. Intervention strategies included role-playing, guided discussion, modeling, and reflective activities embedded within the curriculum framework. Outcomes demonstrated increased participant engagement and improved …

Developing And Implementing Pediatric Pelvic Health Education Groups For Autistic Youth Focused On Toilet Training, Sasha Poland

Capstone Projects

Occupational therapists (OTPs) have a crucial role in treating pelvic health conditions as toileting is an activity of daily living. However, pelvic health research is primarily focused through a physical therapy lens and doesn’t always address challenges pertaining to children, and even more so neurodivergent youth. Furthermore, there is a gap in the literature in how specifically OTPs can assist in providing pelvic health care to all individuals including neurodivergent youth. The goal of this doctoral capstone was to create and provide educational sessions to educate parents, educators, and BCBAs on the role of pelvic health OT in solving their …

The Importance Of Holistic Care: The Development And Implementation Of Spiritual Resources For Caregivers And Staff At Joni’S House El Salvador, Chloe Veilleux

Capstone Projects

It is within the occupational therapy (OT) scope of practice to not only address client needs related to mind, body, and spirit, but also those of caregivers as a means of fostering overall improved quality of life. Additionally, when OTs address spirituality and implement spiritual/spirituality-informed interventions, correlations of improved psychosocial factors such as well-being, motivation, and reduced stress have been shown, as well as improved hope and reduced burden for caregivers. There remains, however, a gap in the research and implementation of spiritually informed care and resources specifically as it pertains to caregivers of those with disabilities. To address this …

Occupational Therapy & Zoo Exhibit Design: Embedding Accessibility Within, Jacqui Randall

Capstone Projects

This doctoral capstone project was completed at the Indianapolis Zoo. Zoos and museums infrequently contract, but very few employ an occupational therapist to assist with exhibit design development. An occupational therapy consultant could assess exhibit accessibility and provide potential solutions to make them more accessible and inclusive for individuals with disabilities. The goal of the project was to create a list of refined recommendations to make the oceans building more accessible and incorporate more multisensory experiences when it is renovated in the spring of 2027. Also, the Accessibility and Sensation Among Zoo Exhibits and Interactives: Checklist and Application Guide was …

Occupational Therapy And Grief: Building Knowledge, Justifying Scope, And Supporting Practice, Jessica Jacques

Capstone Projects

Grief can disrupt individuals’ ability to participate in meaningful daily occupations (Hoppes & Segal, 2010), yet occupational therapy (OT) remains underutilized in grief support. Given OT’s focus on occupational performance, practitioners are uniquely positioned to address the functional and emotional challenges associated with grief. Despite this alignment, a gap exists in structured, occupation-based grief support, as well as limited integration of OT within community-based grief services. This capstone aimed to address this need by developing and implementing grief-informed, occupation-based resources and educational materials. Objectives included revising a grief resource manual, creating evidence-based handouts for community and school settings, promoting sensory …

Sensory Processing At A Children’S Advocacy Center: Staff Education And Resource Development To Support Trauma-Informed Care, Hayley Jackson

Capstone Projects

This capstone addresses a critical gap in understanding sensory processing within trauma-informed care for children who have experienced sexual abuse. Occupational therapy (OT) offers a unique perspective for supporting children’s sensory processing and regulation needs; however, OT is not utilized in Children’s Advocacy Center (CAC) settings. This project aimed to enhance understanding of OT's scope within trauma-informed care, provide education on sensory-based strategies, and develop resources to support regulation in clinical, home, and school settings. Project objectives were achieved through the development of caregiver and educator handouts, a SMART room sensory binder, a visual schedule binder, SMART movement cards, and …

Designing Inclusive Dog Training Opportunities For Handlers With Diverse Access Needs: An Occupational Therapy Approach, Lauren Huffman

Capstone Projects

This doctoral capstone focused on designing inclusive dog training opportunities in the community by integrating occupational therapy approaches to empower meaningful participation and increase carryover of skills into daily life. The project addressed a need for options that are supportive of dog owners (typically referred to as “handlers” in the dog training setting) who experience health and learning barriers impacting human-dog interactions and the ability to attend dog training classes in a group setting. Occupational Therapy’s role in adaptive recreation and use of occupation-based practice guided the development of a foundations-level accessible small group class, individual adaptive sessions, and educational …

Enhancing Feeding Skills: Development And Implementation Of A Pediatric Feeding Group Program In An Outpatient Setting, Alexia Spyrka

Capstone Projects

Children with autism spectrum disorder are five times more likely to present with feeding difficulties when compared to the general pediatric population (Baraskewich,et.al., 2021). Pediatric feeding difficulties can include picky eating, restrictive diets, limited independence with feeding skills, and limited food repertoire. Not only can this effect the child’s nutrition and growth but can affect family members as they are additionally focusing on their child's socialization, communication, and regulation. When addressing feeding difficulties, occupational therapy services are provided 1:1 with clients while educating and supporting family members to improve carry over into the home. However, there is a gap in …

Beyond Baby: How Occupational Therapy Supports Families In The Prenatal And Postpartum Period, Taylor Maysonet

Capstone Projects

This doctoral capstone project focuses on the role of occupational therapy in maternal and infant health, supporting families during the prenatal and postnatal period. While occupational therapy has a strong foundation in promoting health, independence, participation and roles and routines, there remains a gap in community awareness of available support for families during this life transition. Many caregivers report feeling underprepared, overwhelmed, and disconnected from resources that could support their physical, emotional, and occupational wellbeing.

The objective of this project was to identify gaps within the interdisciplinary team during the prenatal and postpartum period. From there, I was able to …

Pivot: Plan For Institutional Vitality And Organizational Transformation, 2025-2026 Report, Office Of Academic Affairs, Research And Graduate Studies, Richard Tankersley, Shelly Chabon

Office of Academic Affairs Publications

This report documents the conduct and results of PIVOT's first review cycle, from its September 2025 launch through the submission of recommendations to President Ann Cudd on February 23, 2026. Track 1 reviewed 293 academic programs, each by three to five academic leaders, with calibration by the Deans' Council and feedback from units before classifications were finalized. Resulting classifications were 25 Grow, 85 Sustain, 112 Revitalize, and 71 Sunset. Track 2 reviewed 163 units through a Core Review Team, producing 7 Invest, 61 Sustain, 54 Reassess, 28 Restructure/Consolidate, and 13 Phase Out classifications. The report presents financial modeling projecting approximately …

Alterations In Ascending Aortic Hemodynamics And Aortic Length Correlate With Sex-Specific Thoracic Aortic Aneurysm Dilation And Lifespan In A Mouse Model Of Severe Marfan Syndrome, Krashn Kr Dwivedi, Yufan Wu, Marisa S Bazzi, Hadi Wiputra, Jacob Rother, James D Quirk, Victor H Barocas, Jessica E Wagenseil

2020-Current year OA Pubs

Thoracic aortic aneurysm (TAA) is a dilation of the aorta that may eventually dissect and/or rupture. It is associated with genetic disorders such as Marfan syndrome (MFS) and is a life-threatening cardiovascular condition if left untreated. Current clinical guidelines for TAA management are primarily based on maximum diameter thresholds that are often inadequate, particularly in MFS patients. Moreover, the diameter thresholds are not sex-specific, despite growing evidence that TAA outcomes in MFS are influenced by sex. The aim of this study was to identify non-invasive biomarkers for better management of TAA using male and female mice that are a genetic …

Life Skills To Promote Independence Following Discharge From Inpatient Psychiatric Care, Alli Bammert

Capstone Projects

This doctoral capstone experience focused on program development through the creation and implementation of a structured life skills program and the initial planning of a simulated life skills training space within an inpatient psychiatric setting at Kalamazoo Psychiatric Hospital. Individuals with serious mental illness often experience barriers to community reintegration following hospitalization and benefit from opportunities to practice daily living skills prior to discharge (Gibson et al., 2011). In response to this need, a 12-week life skills curriculum was developed and piloted to address topics including daily routines, medication management, emotional regulation, grocery shopping, cooking, employment readiness, technology use, and …

An Occupational Therapy Approach To Sensory Education: Training Paraprofessionals To Support Students’ Sensory Needs, Sophia Hubber

Capstone Projects

Sensory processing plays an important role in the development and participation across the lifespan and is a key focus of occupational therapy (OT) in school settings. This doctoral capstone project addresses the gap in sensory education and training among paraprofessionals, who spend much of the day supporting students with the highest level of needs. While occupational therapists have extensive knowledge in sensory processing, their large caseloads often limit the opportunities to provide direct education to staff.

To address this gap, the project involved collaborating with the occupational therapy department, conducting research on sensory processing, and developing five educational videos with …

Draft Final Butte Priority Soils Operable Unit (Bpsou) Insufficiently Reclaimed Sites Sister Dump (Bres No. 38) Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.