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Urethral Caruncle With Associated Renoureteric Anomalies, Sohail Ahmad, Akash B. Pati, Santosh K. Mahalik, Kanishka Das Feb 2023

Urethral Caruncle With Associated Renoureteric Anomalies, Sohail Ahmad, Akash B. Pati, Santosh K. Mahalik, Kanishka Das

Sultan Qaboos University Medical Journal

A urethral caruncle is a rare differential diagnosis for a prolapsed mass at the urethral meatus. The aetiopathogenesis of this entity is unclear. We report a three-year-old female patient who presented to a tertiary care teaching hospital in India in 2019 with intermittent bleeding from the introitus for a month. Investigations revealed a urethral caruncle and associated renal anomalies which has not been described in the previous literature. The patient was discharged with a prescription of a Sitz bath twice daily and advised to apply betamethasone (0.1%) cream locally once daily. There was a significant improvement after six weeks of …


Leukocytoclastic Vasculitis: A Peculiar Presentation Of Scrub Typhus, Anila Vasireddy, Kanthilatha Pai, Varsha M. Shetty, Raviraja V. Acharya, Ramamoorthi Kusugodlu, Akhila Doddamani, Sharath P. Madhyastha Feb 2023

Leukocytoclastic Vasculitis: A Peculiar Presentation Of Scrub Typhus, Anila Vasireddy, Kanthilatha Pai, Varsha M. Shetty, Raviraja V. Acharya, Ramamoorthi Kusugodlu, Akhila Doddamani, Sharath P. Madhyastha

Sultan Qaboos University Medical Journal

Scrub typhus is a disease endemic to the Indian subcontinent caused by the obligate intracellular pleomorphic organism, Orientia tsutsugamushi. Scrub typhus, among other acute febrile illnesses, manifests as prodromal symptoms of fever, malaise, myalgia and anorexia followed by a distinct maculopapular rash, hepatosplenomegaly and lymphadenopathy. We report the case of a patient presenting to tertiary care hospital in southern India in 2021 who developed a rare cutaneous vasculitis secondary to infection with Orientia tsutsugamushi. After performing the Weil-Felix test, a diagnostic titre of >1:640 against OXK was obtained. Furthermore, a skin biopsy was carried out which confirmed the diagnosis of …


20230223_Hslic's Biomedical Informatics Seminar Series Presents- Glyneva Bradley-Ridout, Ba, Mi, And Elena Springall, Bsc, Mlis, Brandon Carroll Feb 2023

20230223_Hslic's Biomedical Informatics Seminar Series Presents- Glyneva Bradley-Ridout, Ba, Mi, And Elena Springall, Bsc, Mlis, Brandon Carroll

HSLIC Blog Post

No abstract provided.


The Montclarion, February 23, 2023, The Montclarion Feb 2023

The Montclarion, February 23, 2023, The Montclarion

The Montclarion

Student Newspaper of Montclair State University


Association Between Serum Vitamin D And Metabolic Syndrome In A Sample Of Adults In Lebanon, Myriam Abboud, Rana Rizk, Suzan Haidar, Nadine Mahboub, Dimitrios Papandreou Feb 2023

Association Between Serum Vitamin D And Metabolic Syndrome In A Sample Of Adults In Lebanon, Myriam Abboud, Rana Rizk, Suzan Haidar, Nadine Mahboub, Dimitrios Papandreou

All Works

The evidence on the association between vitamin D and metabolic syndrome (MetS) is inconclusive. This was a cross-sectional study to explore the relationship between vitamin D serum levels and MetS in a sample of Lebanese adults (n = 230), free of diseases that affect vitamin D metabolism, recruited from an urban large university and neighboring community. MetS was diagnosed according to the International Diabetes Federation criteria. A logistic regression analysis was performed taking MetS as the dependent variable, and vitamin D was forced into the model as an independent variable. The covariates included sociodemographic, dietary, and lifestyle variables. The mean …


The Colby Echo (2023-02-23), Colby College Feb 2023

The Colby Echo (2023-02-23), Colby College

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly during the academic year, 1898-present.


Application Of E-Learning In The Smart City Projects, Asma Ghanim Al Arai Feb 2023

Application Of E-Learning In The Smart City Projects, Asma Ghanim Al Arai

Theses

The concept of smart city is getting popular over time. It uses communication of technology and information to maximize operational organization. It shares information among the public to improve citizen welfare and the services of the government. Smart learning or E-learning is also one of the components of a smart city. Cities are the crucible hub of human innovation. Through smart cities, the community strives to integrate and cover environmental, bio, digital and financial technologies to solve urban problems. The E-learning process is based on formalized teaching, and it enhances with the help of electronic resources. Internet and computers play …


College Of Health Professions News, Georgia Southern University Feb 2023

College Of Health Professions News, Georgia Southern University

College of Health Professions: News & Publications (2012-2023)

  • HSK Faculty Develop No-Cost HAP Library Guide


Hochberg, Marc, Sophia Maier Garcia Feb 2023

Hochberg, Marc, Sophia Maier Garcia

Bronx Jewish History Project

Marc Hochberg was born 1949. He grew up with parents, both the children of immigrants, in a six story apartment building on Holland Avenue, off the south side of Pelham Parkway. The area is remembered as 90% Jewish, with one Italian friend from elementary school. He attended Castle Hill Junior High School in Parkchester, which still had few non-white students at the time, and the Bronx High School of Science. When he was in high school his parents moved to Grand Concourse and 165th Street. Bronx Science is remembered as a top education, and he would go to Franklin and …


Bispecific T-Cell Engagers Therapies In Solid Tumors: Focusing On Prostate Cancer, Diana C Simão, Kevin K Zarrabi, José L Mendes, Ricardo Luz, Jorge A Garcia, William Kevin Kelly, Pedro C Barata Feb 2023

Bispecific T-Cell Engagers Therapies In Solid Tumors: Focusing On Prostate Cancer, Diana C Simão, Kevin K Zarrabi, José L Mendes, Ricardo Luz, Jorge A Garcia, William Kevin Kelly, Pedro C Barata

Department of Medical Oncology Faculty Papers

Over the past decade, immunotherapy has demonstrated an impressive improvement in treatment outcomes for multiple cancers. Following the landmark approvals for use of immune checkpoint inhibitors, new challenges emerged in various clinical settings. Not all tumor types harbor immunogenic characteristics capable of triggering responses. Similarly, many tumors' immune microenvironment allows them to become evasive, leading to resistance and, thus, limiting the durability of responses. To overcome this limitation, new T-cell redirecting strategies such as bispecific T-cell engager (BiTE) have become attractive and promising immunotherapies. Our review provides a comprehensive perspective of the current evidence of BiTE therapies in solid tumors. …


Family Caregivers Of Older Adults With Physical Disabilities In Rural Thailand, Denis Tuttle, Jiranan Griffiths, Anuchart Kaunnil Feb 2023

Family Caregivers Of Older Adults With Physical Disabilities In Rural Thailand, Denis Tuttle, Jiranan Griffiths, Anuchart Kaunnil

The Qualitative Report

Thailand is one of many countries experiencing changes in the demographics of its population. People are living longer and having fewer children resulting in an increasing percentage of older adults in the general population. This presents a challenge in providing care for older adults, especially in countries where there is a culture of family caregiving. This study aims to investigate the experience of family caregivers, exploring the problems of caring for older people with physical disabilities and the needs of family caregivers. This is done to better understand ways to support caregivers. Using a descriptive qualitative approach, 15 family caregivers …


A Comparative Study Of Texas–Mexico Border Vs. Non-Border Students’ Achievement On High-Stakes State Test: A Propensity Score Matching Method, Zhuoying Wang, Shifang Tang, Feng Luo Feb 2023

A Comparative Study Of Texas–Mexico Border Vs. Non-Border Students’ Achievement On High-Stakes State Test: A Propensity Score Matching Method, Zhuoying Wang, Shifang Tang, Feng Luo

Faculty Publications

Texas–Mexico border region is a unique place where two countries and culture connected. We sought to investigate border school district students’ academic performance as measured by Texas standardized test: the State of Texas Assessments of Academic Readiness (STAAR). To do so, we first used propensity score matching (PSM) techniques to analyze data collected from a public database: Texas Assessment Management System (TAMS). Specifically, we provided a PSM analysis of nonborder and border school districts regarding their demographic characteristics [i.e., identified as a rural district, percentage of economically disadvantaged (ED) students, percentage of English learners (ELs), mobility rate, instructional hours, principal …


Cytotoxic And Genotoxic Effects Of Waterpipe On Oral Health Status: Systematic Review And Meta-Analysis, Ricardo Grillo, Mehdi Khemiss, Yuri S. Da Silva Feb 2023

Cytotoxic And Genotoxic Effects Of Waterpipe On Oral Health Status: Systematic Review And Meta-Analysis, Ricardo Grillo, Mehdi Khemiss, Yuri S. Da Silva

Sultan Qaboos University Medical Journal

This systematic review and meta-analysis aimed to assess the cytotoxic and genotoxic impacts of waterpipe smoking on oral health. The databases MEDLINE, Cochrane Library and Dimensions were searched to find studies evaluating whether waterpipe smokers exhibited any cytotoxic or genotoxic effects on their oral cells compared to non-smokers, with regard to mouth neoplasms. Particularly, changes in DNA methylation and p53 expression were assessed. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were adopted for the systematic review. Review Manager was utilised for statistical analysis with a significance level at P <0.05. To assess the grades of the included articles, a risk of bias analysis was summarised. A forest plot, including some of the included articles included, was created regarding the different grades. A total of 20 studies were included in this review. The results showed that waterpipe smoking has cytotoxic and genotoxic effects on oral cells, with a risk difference of 0.16. Although the published articles are few in number, all confirm the devastating effects of waterpipe smoking related to the carcinogenicity. Waterpipe smoking is harmful to oral health. It causes a series of detrimental cellular and genetic modifications such as acanthosis, epithelial dysplasia and hyperparakeratosis. In addition, waterpipe smoke contains several carcinogenic compounds. As it releases many harmful organic compounds, waterpipe smoking increases the incidence of oral cancer.


Social Relationships And Onset Of Functional Limitation Among Older Adults With Chronic Conditions: Does Gender Matter?, Dandan Jiao, Kumi W. Miura, Yuko Sawada, Munenori Matsumoto, Ammara Ajmal, Emiko Tanaka, Taeko Watanabe, Yuka Sugisawa, Sumio Ito, Rika Okumura, Yuriko Kawasaki, Tokie Anme Feb 2023

Social Relationships And Onset Of Functional Limitation Among Older Adults With Chronic Conditions: Does Gender Matter?, Dandan Jiao, Kumi W. Miura, Yuko Sawada, Munenori Matsumoto, Ammara Ajmal, Emiko Tanaka, Taeko Watanabe, Yuka Sugisawa, Sumio Ito, Rika Okumura, Yuriko Kawasaki, Tokie Anme

Sultan Qaboos University Medical Journal

Objectives: This study aimed to examine the longitudinal association between social relationships and physical functioning among community-dwelling older adults with chronic conditions. Methods: Self-reported questionnaires were distributed and collected between 2014 and 2017 from participants ≥65 years old. The Index of Social Interaction was used to evaluate social relationships and the instrumental activities of daily living (IADL) subscale of the Tokyo Metropolitan Institute of Gerontology Index of Competence was used to examine functional status. Results: A total of 422 participants (190 males and 232 females) were included in the final analysis. High social relationships demonstrated significant adverse effects (odds ratio …


Patterns Of Movement Performance Among Japanese Children And Effects Of Parenting Practices: Latent Class Analysis, Zhu Zhu, Cunyoen Kim, Dandan Jiao, Xiang Li, Ammara Ajmal, Munenori Matsumoto, Yuko Sawada, Toshiyuki Kasai, Taeko Watanabe, Etsuko Tomisaki, Emiko Tanaka, Sumio Ito, Rika Okumura, Tokie Anme Feb 2023

Patterns Of Movement Performance Among Japanese Children And Effects Of Parenting Practices: Latent Class Analysis, Zhu Zhu, Cunyoen Kim, Dandan Jiao, Xiang Li, Ammara Ajmal, Munenori Matsumoto, Yuko Sawada, Toshiyuki Kasai, Taeko Watanabe, Etsuko Tomisaki, Emiko Tanaka, Sumio Ito, Rika Okumura, Tokie Anme

Sultan Qaboos University Medical Journal

Objectives: This study aimed to examine the long-term effects of parenting practice during preschool years on children’s movement performance in primary school. Methods: This three-year longitudinal study included 225 children aged 3–6-years-old. Parents reported baseline parenting practice and evaluated children’s movement performance three years later. Latent class analysis was used to explore latent classes of movement performance. A post hoc test was used to identify the characteristics of different patterns. Finally, adjusted multinomial logistic regression models were used to test the influence of parenting practice on identified patterns of movement performance. Results: Children in this study were grouped into three …


Acquired Uterine Vascular Anomaly: Experience From A Tertiary Care Centre In Pakistan, Kulsoom Fatima, Mustafa Ba Zubairi, Muhammad Azeemuddin, Raza Sayani Feb 2023

Acquired Uterine Vascular Anomaly: Experience From A Tertiary Care Centre In Pakistan, Kulsoom Fatima, Mustafa Ba Zubairi, Muhammad Azeemuddin, Raza Sayani

Sultan Qaboos University Medical Journal

Objectives: This study aimed to retrospectively review imaging findings and the outcomes of uterine artery embolisation (UAE) in symptomatic uterine vascular anomalies (UVA). Methods: This study included a total of 15 patients with acquired UVA admitted to the Aga Khan University Hospital in Karachi, Pakistan, from 2010 to 2020. These patients were evaluated using ultrasound, computed tomography and magnetic resonance imaging, either alone or in combination. All patients had a history of dilatation and curettage or uterine instrumentation and underwent angiography and embolisation of the uterine arteries. The primary outcome post embolisation was assessed clinically and/or in combination with ultrasound. …


Radiologic Assessment Of Orbital Dimensions Among Omani Subjects: A Computed Tomography Imaging-Based Study At A Single Tertiary Centre, Eiman Al Ajmi, Marwa Al Subhi, Mallak Al Maamari, Humoud Al Dhuhli, Srinivasa R. Sirasanagandla Feb 2023

Radiologic Assessment Of Orbital Dimensions Among Omani Subjects: A Computed Tomography Imaging-Based Study At A Single Tertiary Centre, Eiman Al Ajmi, Marwa Al Subhi, Mallak Al Maamari, Humoud Al Dhuhli, Srinivasa R. Sirasanagandla

Sultan Qaboos University Medical Journal

Objectives: This study aimed to determine the orbital dimensions of Omani subjects who had been referred for computed tomography (CT) of the brain at Sultan Qaboos University Hospital, Muscat, Oman. Good knowledge of the normal orbital dimensions is clinically essential for successful surgical outcomes. Racial, ethnic and regional variations in the orbital dimensions have been reported. Methods: A total of 273 Omani patients referred for CT scans of the brain were retrospectively evaluated using an electronic medical records database. The orbital dimensions were recorded using both axial and sagittal planes of CT images. Results: The mean orbital index (OI) was …


Cilia Ultrastructure Associated With Primary Ciliary Dyskinesia In Omani Patients, Kawther Al Adawi, Taher Baomar, Marwa Al Riyami, Nawal Al Shamli, Khoula Al Shidhani, Aliya Al Ansari, Hussein Al Kindi Feb 2023

Cilia Ultrastructure Associated With Primary Ciliary Dyskinesia In Omani Patients, Kawther Al Adawi, Taher Baomar, Marwa Al Riyami, Nawal Al Shamli, Khoula Al Shidhani, Aliya Al Ansari, Hussein Al Kindi

Sultan Qaboos University Medical Journal

Objectives: Primary ciliary dyskinesia (PCD) is a disorder affecting the structure and function of the motile cilia of the respiratory system. Transmission electron microscopy is one method that can be used to examine ciliary ultrastructure in airway biopsies. Although the role of ultrastructural findings in PCD has been described in the literature, this role has not been well-studied in the Middle East or, specifically, Oman. This study aimed to describe ultrastructural features in Omani patients with high suspicion of PCD. Methods: This retrospective cross-sectional study included 129 adequate airway biopsies obtained from Omani patients attending pulmonary clinics at Sultan Qaboos …


Establishing Trimester-Specific Haemoglobin A1c Reference Intervals In Pregnant Women: A Retrospective Study Of Healthy South Asian Women With Normal Pregnancy Outcomes, John Punnose, Rajeev K. Malhotra, Komal Sukhija, Rashika M. Rijhwani, Asha Sharma, Naimaa Choudhary, Prassan Vij, Renuka Joseph Feb 2023

Establishing Trimester-Specific Haemoglobin A1c Reference Intervals In Pregnant Women: A Retrospective Study Of Healthy South Asian Women With Normal Pregnancy Outcomes, John Punnose, Rajeev K. Malhotra, Komal Sukhija, Rashika M. Rijhwani, Asha Sharma, Naimaa Choudhary, Prassan Vij, Renuka Joseph

Sultan Qaboos University Medical Journal

Objectives: This study aimed to define trimester-specific haemoglobin A1c (HbA1c) reference intervals in healthy, pregnant South Asian women. Methods: This retrospective study was conducted at St. Stephen’s Hospital, Delhi, India, between January 2011 and December 2016. Healthy pregnant women were compared to a control group of healthy non-pregnant women. Pregnant participants had term deliveries of babies with appropriate gestational weights. The HbA1c levels were calculated in terms of non-parametric 2.5 and 97.5 percentiles for women in first (T1), second (T2) and third (T3) trimester groups. Statistical tests were used to obtain the normal HbA1c reference values and were considered significant …


Knowledge, Attitudes And Practices Regarding Traditional And Complementary Medicine In Oman, Hassan Al-Riyami, Ahmed Al-Maskari, Sunil K. Nadar, Mohammed Almaskari Feb 2023

Knowledge, Attitudes And Practices Regarding Traditional And Complementary Medicine In Oman, Hassan Al-Riyami, Ahmed Al-Maskari, Sunil K. Nadar, Mohammed Almaskari

Sultan Qaboos University Medical Journal

Objectives: This study aimed to assess the knowledge, attitudes and practices regarding traditional medicine (TM) in Oman and examine the factors that necessitate its use. Methods: This cross-sectional, questionnaire-based study was conducted among the general population from November 2019 and March 2020. All Omani nationals above the age of 18 were eligible to be enrolled. The questionnaire consisted of questions on the knowledge, attitudes and use regarding traditional medicine in Oman. Results: A total of 598 responses to the questionnaire were received (response rate: 85.4%), of which 552 were deemed complete. Most responses were received from males (62.5%) and the …


Loeffler's Syndrome And Multifocal Cutaneous Larva Migrans: Case Report Of An Uncommon Occurrence And Review Of The Literature, Abheek Sil, Dibyendu B. Bhanja, Atanu Chandra, Surajit K. Biswas Feb 2023

Loeffler's Syndrome And Multifocal Cutaneous Larva Migrans: Case Report Of An Uncommon Occurrence And Review Of The Literature, Abheek Sil, Dibyendu B. Bhanja, Atanu Chandra, Surajit K. Biswas

Sultan Qaboos University Medical Journal

Cutaneous larva migrans (CLM) is a zoonotic skin disease that is frequently diagnosed in tropical and subtropical countries. Loeffler’s syndrome (LS) is a transient respiratory ailment characterised by pulmonary infiltration along with peripheral eosinophilia and commonly follows parasitic infestation. We report a 33-year-old male patient who presented to a tertiary care hospital in eastern India in 2019 with LS that was attributed secondary to multifocal CLM. Treatment with seven-day course of oral albendazole (400 mg daily) coupled with nebulisation (levosalbutamol and budesonide) led to complete resolution of cutaneous lesions and respiratory complaints within two weeks. There was complete resolution of …


Standardized Exclusion: A Theory Of Barrier Lock-In, Andrew Tisinger Feb 2023

Standardized Exclusion: A Theory Of Barrier Lock-In, Andrew Tisinger

Duke Law Journal

The United States has relaxed antitrust scrutiny of private standard-setting organizations in recognition of their potential procompetitive benefits. In the meantime, however, the growing importance of network industries—and the coinciding move toward vendor-led standards consortia—has welcomed new, insidious anticompetitive risks. This Note proffers one such risk: barrier lock-in. A theory of barrier lock-in recognizes that dominant vendors can capture and control standards consortia to keep standardized equipment complex and costly. These practices are exclusionary. This Note situates barrier lock-in within the existing antitrust literature and jurisprudence, provides a potential example of barrier lock-in in the 5G network equipment standardization process, …


Legal Strategies To Minimize Subway Air Pollution In The United States, Maia Foster Feb 2023

Legal Strategies To Minimize Subway Air Pollution In The United States, Maia Foster

Duke Law Journal

Air pollution in U.S. subway systems poses a major threat to public health. People in subway stations breathe in dangerously high levels of dusts, called particulate matter. Current legislation does not effectively address this problem; in fact, the United States does not have a comprehensive indoor air quality law at all. Left unregulated, people regularly exposed to subway air pollution could suffer respiratory and cardiovascular issues and even premature death.

To mitigate these health effects, some countries have imposed PM standards in subway systems and underground spaces. Others have standards covering all indoor spaces. In the United States, many subway …


Neutrosophic Critic Mcdm Methodology For Ranking Factors And Needs Of Customers In Product's Target Demographic In Virtual Reality Metaverse, Ahmed Sleem, Nehal Mostafa, Ibrahim Elhenawy Feb 2023

Neutrosophic Critic Mcdm Methodology For Ranking Factors And Needs Of Customers In Product's Target Demographic In Virtual Reality Metaverse, Ahmed Sleem, Nehal Mostafa, Ibrahim Elhenawy

Neutrosophic Systems with Applications

Affective design has come to place a premium on customer-centric creativity, which ultimately results in the creation of a product tailored to the requirements of a certain demographic. Designing a fresh and original item that appeals to clients remains challenging, despite the abundance of literature on customer-centric creativity and impact product design. This is so because optimizing technological and aesthetical design aspects and variables for a group of consumers is highly complicated, and for the same reasons that it is hard to know a customer's choice, enable the product's functioning, etc. One of the most important parts of creating cutting-edge …


Epidemiology Of Common Ocular Manifestations Among Patients On Haemodialysis In West Bank, Palestine, Yousef Shanti, Hamza Hamayel, Anas Yasin, Abdul-Raheem Abu Shanab, Osama Hroub, Zakaria Hamdan, Mujahed Shraim Feb 2023

Epidemiology Of Common Ocular Manifestations Among Patients On Haemodialysis In West Bank, Palestine, Yousef Shanti, Hamza Hamayel, Anas Yasin, Abdul-Raheem Abu Shanab, Osama Hroub, Zakaria Hamdan, Mujahed Shraim

Sultan Qaboos University Medical Journal

Objectives: This study aimed to assess the prevalence of ocular manifestations and associated factors in patients on haemodialysis. Methods: A cross-sectional study of patients on haemodialysis from a haemodialysis unit in Nablus, Palestine, was conducted. Medical examination for ocular manifestations (intraocular pressure, cataract, retinal changes and optic neuropathy) was performed using Tono-Pen, portable slit-lamp and indirect ophthalmoscope. Predictor variables were age, gender, smoking, medical comorbidities (diabetes, hypertension, ischaemic heart disease [IHD], peripheral arterial disease [PAD]) and use of antiplatelet or anti-coagulation medications. Results: A total of 191 patients were included in this study. The prevalence of any ocular manifestation in …


Faculty Senate Agenda, Georgia Southern University, Faculty Senate Feb 2023

Faculty Senate Agenda, Georgia Southern University, Faculty Senate

Faculty Senate Agendas

No abstract provided.


The Kenyon Collegian - February 23, 2023 Feb 2023

The Kenyon Collegian - February 23, 2023

The Kenyon Collegian

No abstract provided.


Addressing Barriers In Fair Data Practices For Biomedical Data, Laura D Hughes, Ginger Tsueng, Jack Digiovanna, Thomas D Horvath, Luke V Rasmussen, Tor C Savidge, Thomas Stoeger, Serdar Turkarslan, Qinglong Wu, Chunlei Wu, Andrew I Su, Lars Pache, Niaid Systems Biology Data Dissemination Working Group Feb 2023

Addressing Barriers In Fair Data Practices For Biomedical Data, Laura D Hughes, Ginger Tsueng, Jack Digiovanna, Thomas D Horvath, Luke V Rasmussen, Tor C Savidge, Thomas Stoeger, Serdar Turkarslan, Qinglong Wu, Chunlei Wu, Andrew I Su, Lars Pache, Niaid Systems Biology Data Dissemination Working Group

Faculty, Staff and Students Publications

No abstract provided.


Macroh2a Histone Variants Modulate Enhancer Activity To Repress Oncogenic Programs And Cellular Reprogramming, Wazim Mohammed Ismail, Amelia Mazzone, Flavia G Ghiraldini, Jagneet Kaur, Manvir Bains, Amik Munankarmy, Monique S Bagwell, Stephanie L Safgren, John Moore-Weiss, Marina Buciuc, Lynzie Shimp, Kelsey A Leach, Luis F Duarte, Chandandeep S Nagi, Saul Carcamo, Chi-Yeh Chung, Dan Hasson, Neda Dadgar, Jian Zhong, Jeong-Heon Lee, Fergus J Couch, Alexander Revzin, Tamas Ordog, Emily Bernstein, Alexandre Gaspar-Maia Feb 2023

Macroh2a Histone Variants Modulate Enhancer Activity To Repress Oncogenic Programs And Cellular Reprogramming, Wazim Mohammed Ismail, Amelia Mazzone, Flavia G Ghiraldini, Jagneet Kaur, Manvir Bains, Amik Munankarmy, Monique S Bagwell, Stephanie L Safgren, John Moore-Weiss, Marina Buciuc, Lynzie Shimp, Kelsey A Leach, Luis F Duarte, Chandandeep S Nagi, Saul Carcamo, Chi-Yeh Chung, Dan Hasson, Neda Dadgar, Jian Zhong, Jeong-Heon Lee, Fergus J Couch, Alexander Revzin, Tamas Ordog, Emily Bernstein, Alexandre Gaspar-Maia

Faculty, Staff and Students Publications

Considerable efforts have been made to characterize active enhancer elements, which can be annotated by accessible chromatin and H3 lysine 27 acetylation (H3K27ac). However, apart from poised enhancers that are observed in early stages of development and putative silencers, the functional significance of cis-regulatory elements lacking H3K27ac is poorly understood. Here we show that macroH2A histone variants mark a subset of enhancers in normal and cancer cells, which we coined 'macro-Bound Enhancers', that modulate enhancer activity. We find macroH2A variants localized at enhancer elements that are devoid of H3K27ac in a cell type-specific manner, indicating a role for macroH2A at …


Montana Kaimin, February 23, 2023, Students Of The University Of Montana, Missoula Feb 2023

Montana Kaimin, February 23, 2023, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.