Digital Commons Network^™

Developing Consensus On Clinical Outcomes For Children With Mild Pneumonia: A Delphi Study, Todd A Florin, Joy Melnikow, Melissa Gosdin, Ryan Ciuffetelli, Jillian Benedetti, Dustin Ballard, Marianne Gausche-Hill, Matthew P Kronman, Lisa A Martin, Rakesh D Mistry, Mark I Neuman, Debra L Palazzi, Sameer J Patel, Wesley H Self, Samir S Shah, Sonal N Shah, Susan Sirota, Andrea T Cruz, Richard Ruddy, Jeffrey S Gerber, Nathan Kuppermann

Faculty, Staff and Students Publications

BACKGROUND: The absence of consensus for outcomes in pediatric antibiotic trials is a major barrier to research harmonization and clinical translation. We sought to develop expert consensus on study outcomes for clinical trials of children with mild community-acquired pneumonia (CAP).

METHODS: Applying the Delphi method, a multispecialty expert panel ranked the importance of various components of clinical response and treatment failure outcomes in children with mild CAP for use in research. During Round 1, panelists suggested additional outcomes in open-ended responses that were added to subsequent rounds of consensus building. For Rounds 2 and 3, panelists were provided their own …

Clinical Reasoning In Experienced Nurses, Barbara Simmons

Dissertations

This qualitative descriptive study was designed to explore the cognitive strategies used by experienced nurses as they think about assessment findings on their assigned patients. As an essential component of nursing practice, clinical reasoning is used to assimilate information, analyze data, and make decisions regarding patient care. Changes in health care settings and patient acuity challenge nurses to make complex decisions under conditions of uncertainty and risk. With fewer expert nurses available to act as mentors, experienced nurses who are not yet experts must utilize varied reasoning strategies to care for acutely ill patients. Few studies of nurses' clinical reasoning …

Impact Of Penicillin Allergy Labels On Children Treated For Outpatient Respiratory Infections, Torsten Joerger, Margaret G Taylor, Yun Li, Debra L Palazzi, Jeffrey S Gerber

Faculty, Staff and Students Publications

BACKGROUND: Penicillin allergy is the most common antibiotic allergy, yet most children labeled as allergic tolerate penicillin. The impact of inaccurate penicillin allergy labels (PALs) on pediatric outpatients is unknown. The objective of this study was to compare outcomes between children with and without a PAL after treatment for outpatient respiratory tract infections (RTI).

METHODS: A retrospective, longitudinal birth cohort study was performed in children who received care in 90 pediatric primary care practices in Philadelphia and Houston metropolitan areas. Prescribing and clinical outcomes of children with a PAL at the time of an RTI were compared to non-allergic children, …

Alumni Spotlight: Jordan Eyal ’17 Wants To Speak Your Language, Julia Sonenshein

NYLS Community News

No abstract provided.

Phytochemicals Profiling Of Blue-Green Alga Nostoc Sp. Hanl07: Antioxidant, Antibacterial Activity And Gc-Ms Analysis, Ritu Chauhan, Ashutosh Tripathi, Abhishek Chauhan, Anuj Ranjan, Hardeep Singh Tuli, Hadi Sajid Abdulabbas, Subhash C. Chauhan, Tanu Jindal

School of Medicine Publications

In recent years, studies on phytochemicals, antioxidants, and antibiotics using blue green algae from harsh environments has become increasingly prevalent. The search for novel bioactive molecules exhibiting diverse biological activity is one of the most important strategies for addressing the issue of rising concerns regarding bacterial antibiotic resistance. In present study, the phytochemicals, antioxidant potentiality and antibacterial assessment of organic solvent extracts of blue-green alga isolated from Naini lake water were characterized. From the mass culture of alga, extracts were prepared in MeOH, EtOH, acetone, AcOEt, hexane and DCM and antioxidant potential and antibacterial properties were studied against multiple antibiotic-resistant …

Mecp2 Regulates Gdf11, A Dosage-Sensitive Gene Critical For Neurological Function, Sameer S Bajikar, Ashley G Anderson, Jian Zhou, Mark A Durham, Alexander J Trostle, Ying-Wooi Wan, Zhandong Liu, Huda Y Zoghbi

Faculty, Staff and Students Publications

Loss- and gain-of-function of MeCP2 causes Rett syndrome (RTT) and MECP2 duplication syndrome (MDS), respectively. MeCP2 binds methyl-cytosines to finely tune gene expression in the brain, but identifying genes robustly regulated by MeCP2 has been difficult. By integrating multiple transcriptomics datasets, we revealed that MeCP2 finely regulates growth differentiation factor 11 (Gdf11). Gdf11 is down-regulated in RTT mouse models and, conversely, up-regulated in MDS mouse models. Strikingly, genetically normalizing Gdf11 dosage levels improved several behavioral deficits in a mouse model of MDS. Next, we discovered that losing one copy of Gdf11 alone was sufficient to cause multiple neurobehavioral …

Parasitoid Wasps Of The Invasive Brown Marmorated Stink Bug In Utah, Zachary R. Schumm, Kate V. Richardson, Mark Cody Holthouse, Yota Mizuno, Diane G. Alston, Lori R. Spears

All Current Publications

The brown marmorated stink bug (BMSB, Halyomorpha halys Stål), an invasive insect from eastern Asia, is causing nuisance problems and agricultural damage in northern Utah. Insecticide applications to control this pest are not sustainable, and therefore the focus is on biological control through the use of parasitoid wasps that sting and kill stink bug eggs. Surveys are underway in Utah to search for Samurai wasp (Trissolcus Japonicus [Ashmead]), a parasitoid wasp native to BMSB’s home range that has been found in 12 U.S. States, and is highly effective at killing BMSB eggs. While Samurai wasp has not been found, …

Uncovering Novel Regulators Of Memory Using C Elegans Genetic And Genomic Analysis, Katie L Brandel-Ankrapp, Rachel N Arey

Faculty, Staff and Students Publications

How organisms learn and encode memory is an outstanding question in neuroscience research. Specifically, how memories are acquired and consolidated at the level of molecular and gene pathways remains unclear. In addition, memory is disrupted in a wide variety of neurological disorders; therefore, discovering molecular regulators of memory may reveal therapeutic targets for these disorders. C. elegans are an excellent model to uncover molecular and genetic regulators of memory. Indeed, the nematode's invariant neuronal lineage, fully mapped genome, and conserved associative behaviors have allowed the development of a breadth of genetic and genomic tools to examine learning and memory. In …

The Tfiis N-Terminal Domain (Tnd): A Transcription Assembly Module At The Interface Of Order And Disorder, Katerina Cermakova, Vaclav Veverka, H Courtney Hodges

Faculty, Staff and Students Publications

Interaction scaffolds that selectively recognize disordered protein strongly shape protein interactomes. An important scaffold of this type that contributes to transcription is the TFIIS N-terminal domain (TND). The TND is a five-helical bundle that has no known enzymatic activity, but instead selectively reads intrinsically disordered sequences of other proteins. Here, we review the structural and functional properties of TNDs and their cognate disordered ligands known as TND-interacting motifs (TIMs). TNDs or TIMs are found in prominent members of the transcription machinery, including TFIIS, super elongation complex, SWI/SNF, Mediator, IWS1, SPT6, PP1-PNUTS phosphatase, elongin, H3K36me3 readers, the transcription factor MYC, and …

Comparison Of Oxygen Supplementation In Very Preterm Infants: Variations Of Oxygen Saturation Features And Their Application To Hypoxemic Episode Based Risk Stratification, Pravitha Ramanand, Premananda Indic, Colm P. Travers, Namasivayam Ambalavanan

Electrical Engineering Faculty Publications and Presentations

Background: Oxygen supplementation is commonly used to maintain oxygen saturation (SpO2) levels in preterm infants within target ranges to reduce intermittent hypoxemic (IH) events, which are associated with short- and long-term morbidities. There is not much information available about differences in oxygenation patterns in infants undergoing such supplementations nor their relation to observed IH events. This study aimed to describe oxygenation characteristics during two types of supplementation by studying SpO2 signal features and assess their performance in hypoxemia risk screening during NICU monitoring. Subjects and methods: SpO2 data from 25 infants with gestational age  0.80, F1 score > 0.60 and specificity …

A Systematic Review To Explore How Exercise-Based Physiotherapy Via Telemedicine Can Promote Health Related Benefits For People With Cystic Fibrosis., B Bowhay, J Latour, Ow Tomlinson

School of Nursing and Midwifery

No abstract provided.

A Systematic Review And Meta-Analysis Of Self-Guided Online Acceptance And Commitment Therapy As A Transdiagnostic Self-Help Intervention, Korena S. Klimczak, Guadalupe G. San Miguel, Miriam N. Mukasa, Michael P. Twohig, Michael E. Levin

Psychology Student Research

Online Acceptance and Commitment Therapy (ACT) interventions use websites and smartphone apps to deliver ACT exercises and skills. The present meta-analysis provides a comprehensive review of online ACT self-help interventions, characterizing the programs that have been studied (e.g. platform, length, content) and analyzing their efficacy. A transdiagnostic approach was taken, including studies that addressed a range of targeted problems and populations. Multi-level meta-analyses were used to nest multiple measures of a single construct within their respective studies. A total of 53 randomized controlled trials were included (n = 10,730). Online ACT produced significantly greater outcomes than waitlist controls at …

Care Of Bullet-Related Injuries: A Cross-Sectional Study Of Instructions And Prescriptions Provided On Discharge From The Emergency Department, Jane M. Hayes, L J. Punch, Kristen L. Mueller

2020-Current year OA Pubs

INTRODUCTION: There are more than 80,000 emergency department (ED) visits for non-fatal bullet-related injuries (BRI) per year in the United States. Approximately half of these patients are discharged home from the ED. Our objective in this study was to characterize the discharge instructions, prescriptions, and follow-up plans provided to patients discharged from the ED after BRI.

METHODS: This was a single-center, cross-sectional study of the first 100 consecutive patients who presented to an urban, academic, Level I trauma center ED with an acute BRI beginning on January 1, 2020. We queried the electronic health record for patient demographics, insurance status, …

Orthodenticle Homeobox 2 Is Transported To Lysosomes By Nuclear Budding Vesicles, Jun Woo Park, Eun Jung Lee, Eunyoung Moon, Hong-Lim Kim, In-Beom Kim, Didier Hodzic, Namsuk Kim, Hee-Seok Kweon, Jin Woo Kim

2020-Current year OA Pubs

Transcription factors (TFs) are transported from the cytoplasm to the nucleus and disappear from the nucleus after they regulate gene expression. Here, we discover an unconventional nuclear export of the TF, orthodenticle homeobox 2 (OTX2), in nuclear budding vesicles, which transport OTX2 to the lysosome. We further find that torsin1a (Tor1a) is responsible for scission of the inner nuclear vesicle, which captures OTX2 using the LINC complex. Consistent with this, in cells expressing an ATPase-inactive Tor1aΔE mutant and the LINC (linker of nucleoskeleton and cytoskeleton) breaker KASH2, OTX2 accumulated and formed aggregates in the nucleus. Consequently, in the mice expressing …

Long-Term Intensive Endurance Exercise Training Is Associated To Reduced Markers Of Cellular Senescence In The Colon Mucosa Of Older Adults, Marco Demaria, Beatrice Bertozzi, Nicola Veronese, Francesco Spelta, Edda Cava, Valeria Tosti, Laura Piccio, Dayna S Early, Luigi Fontana

2020-Current year OA Pubs

Regular endurance exercise training is an effective intervention for the maintenance of metabolic health and the prevention of many age-associated chronic diseases. Several metabolic and inflammatory factors are involved in the health-promoting effects of exercise training, but regulatory mechanisms remain poorly understood. Cellular senescence-a state of irreversible growth arrest-is considered a basic mechanism of aging. Senescent cells accumulate over time and promote a variety of age-related pathologies from neurodegenerative disorders to cancer. Whether long-term intensive exercise training affect the accumulation of age-associated cellular senescence is still unclear. Here, we show that the classical senescence markers p16 and IL-6 were markedly …

Trpv1-Mediated Sonogenetic Neuromodulation Of Motor Cortex In Freely Moving Mice, Kevin Xu, Yaoheng Yang, Zhongtao Hu, Yimei Yue, Yan Gong, Jianmin Cui, Joseph P Culver, Michael R Bruchas, Hong Chen

2020-Current year OA Pubs

No abstract provided.

A Semiotic Paradox: Scientific Language In The Narrative Of Tv Advertisement-, Maria Jesus De Prada Vicente

CLCWeb: Comparative Literature and Culture

The narrative we find in TV advertisement especially abounds in scientific terms that the　viewers hardly understand. The apparently ‘scientific’ language induces them to believe in the modern myth of science as absolute truth, which inevitably produces alienation from reality. The more such language triumphs, the more alienation they suffer without knowing it. Such is our situation today that reminds us of the time of Nazi in which alienating language was dominant. However, whether the use of scientific language on TV advertisement becomes alienating or not depends on the socio-cultural context of the viewers. For example, in Japan where the …

Language, Science And Literature, Hitoshi Oshima

CLCWeb: Comparative Literature and Culture

The creativity of language Chomsky puts so much importance on must be questioned because the same creativity has produced lethal weapons such as atomic bombs. Modern science developed by the power of language has certainly produced many beneficial things, but we should not overlook its destructive side. Besides, language capable of inventing a new reality leads us to believe in it blindly. Let us remember philosophers such as Wittgenstein or Nagarjuna who warned us not to believe in the construct called “reality” made up by language power.Now, is it better and safer then to use a metaphorical language that composes …

Ultrasound-Assisted Air-Jet Spinning Of Silk Fibroin-Soy Protein Nanofiber Composite Biomaterials., Futian Yang, Fang Wang, Janine Mazahreh, Xiao Hu

College of Science & Mathematics Departmental Research

Ultrasound utilizes a non-radiation technology that can meet modern standards to gain access to cheap, reliable and sustainable modern energy. Ultrasound technology can be implemented in the field of biomaterials for its exceptional potential in controlling the shape of nanomaterials. This study presents the first example of the production of soy and silk fibroin protein composite nanofibers in various ratios via combining ultrasonic technology with air-spray spinning. Characterization of ultrasonic spun nanofibers was performed by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric (TG) analysis, water contact angle, water retention, enzymatic …

Ambient Electromagnetic Radiation As A Predictor Of Honey Bee (Apis Mellifera) Traffic In Linear And Non-Linear Regression: Numerical Stability, Physical Time And Energy Efficiency, Vladimir Kulyukin, Daniel Coster, Anastasiia Tkachenko, Daniel Hornberger, Aleksey V. Kulyukin

Computer Science Faculty and Staff Publications

Since bee traffic is a contributing factor to hive health and electromagnetic radiation has a growing presence in the urban milieu, we investigate ambient electromagnetic radiation as a predictor of bee traffic in the hive’s vicinity in an urban environment. To that end, we built two multi-sensor stations and deployed them for four and a half months at a private apiary in Logan, Utah, U.S.A. to record ambient weather and electromagnetic radiation. We placed two non-invasive video loggers on two hives at the apiary to extract omnidirectional bee motion counts from videos. The time-aligned datasets were used to evaluate 200 …

The Evolution Of The Institution Of Waqf In Its Historical Context In The Middle East: An Alternative View, Sobir Komilov

Journal of King Abdulaziz University: Islamic Economics

This paper studies the concept of waqf in its historical evolution in order to understand its role as a substitute for government in providing social services to the most vulnerable parts of the population in Islamic history since the 7th century. In the literature, there are mainly two schools that explain why awqaf flourished during the medieval period with some ups and downs until the end of Ottoman rule with the fall and near disappearance of awqaf in the Middle East after the fall of the Ottoman Empire. The first school, among which orientalists constitute the majority, consider awqaf as …

Muhammad Abdul Mannan: Reading Into His Contributions On Islamic Economics, Foyasal Khan

Journal of King Abdulaziz University: Islamic Economics

This paper examines the major theoretical and practical contributions of Muhammad Abdul Mannan (1938-2021) to Islamic economics. The paper uses primarily the library research method and some interviews. Muhammad Abdul Mannan was a pioneering figure who made enormous contributions to Islamic economics to establish it as a distinct social science and a separate discipline of study. His unique perspective on Islamic approaches to consumption, production, and distribution, as well as the state's role and the social security system in an Islamic economy, enriched theoretical knowledge in Islamic economics. In addition, as a visionary, lifelong educator, and philanthropist, he left his …

Florawear: Wearable Living Interface, Hye Yeon Nam, Janiece Campbell, Andrew M. Webb, Brendan Harmon

Faculty Publications

While nature can benefit people both mentally and physically, contemporary society has become increasingly disconnected from nature. To rebuild a stronger connection with nature in our everyday life, we introduce FloraWear, a do-it-yourself, wearable living interface, that enables people to easily and closely connect with plants. This pictorial introduces how knowledge is built and shared with others using hybrid craft and fabrication, illustrates the material experiments and design development for FloraWear, and discusses how it affects wearers. Then we summarize how FloraWear can help catalyze a shift in people's perspectives towards nature. By developing emotional ties to their wearable plants, …

Socio-Demographic, Clinical Characteristics And Risk Factors Of Crystal Meth Use In Baghdad/Iraq, Noor Emad Chachan‍, Nesif J. Al-Hemiary

Muthanna Medical Journal

Major amphetamines include dextroamphetamine, methamphetamine, a combined dextroamphetamine amphetamine salt, and methylphenidate. The narcotics are called crystal or crystal meth. Amphetamines are used to boost performance and produce euphoria by students preparing for exams, long-distance truck drivers on travels, businesspeople with significant deadlines, athletes in competition, and troops in combat. Little is known regarding Iraqi crystal usage. The aim of study is to find out the sociodemographic and clinical characteristic of patient crystal meth use in Iraq and the risk factors of this use. Method: A cross sectional study conducted among 100 patients who were attending Ibn Rushid Psychiatric Training …

Heart Rate Variability (Hrv) Loss And Other Ekg Changes Prior To A Cardiopulmonary Event In Children Admitted To The Icu At A Tertiary Care Children’S Hospital, Sabrina R. Orta, Shreya Chandran, Utpal Bhalala

MEDI 9331 Scholarly Activities Clinical Years

Introduction: HRV and EKG changes prior to cardiopulmonary events (CPEs) occurring in children in intensive care unit (ICU) settings is not well documented. We assess if substantial losses of HRV and/or other EKG changes, if any, may be detectable prior to a CPE occurring in children admitted to the ICU.

Methods: A prospective observational cohort study was conducted in the ICU from January to February of 2023 at Driscoll Children’s Hospital. A “CPE” was defined as a change in the clinical status of a child warranting a cardiopulmonary intervention. Demographic and clinical data from each patient was collected, …

Islamic Human Development Index (I-Hdi) And Poverty Reduction In Oic Countries, Maizura Md Isa, Mohamed Ariff Abdul Kareem, Mohamed Eskandar Shah, Nasim S. Shirazi

Journal of King Abdulaziz University: Islamic Economics

The fight against poverty requires a broader perspective than simply focusing on the issue of income insufficiency. Thus, adopting human development strategies is relevant to poverty alleviation because it provides an incentive to broaden the database on poverty by studying the deprivation of a human being's functioning and capabilities. The United Nations Development Program (UNDP) has developed the Human Development Index (HDI), considered the most comprehensive indicator. However, it is not fully compatible and sufficient to measure human development from the Islamic perspective. This study attempts to explore the Islamic Human Development Index (i-HDI) based on the five pillars of …

Kras-Mutant Lung Cancer: Targeting Molecular And Immunologic Pathways, Therapeutic Advantages And Restrictions, Nastaran Karimi, Seyed Javad Moghaddam

Faculty, Staff and Student Publications

RAS mutations are among the most common oncogenic mutations in human cancers. Among RAS mutations, KRAS has the highest frequency and is present in almost 30% of non-small-cell lung cancer (NSCLC) patients. Lung cancer is the number one cause of mortality among cancers as a consequence of outrageous aggressiveness and late diagnosis. High mortality rates have been the reason behind numerous investigations and clinical trials to discover proper therapeutic agents targeting KRAS. These approaches include the following: direct KRAS targeting; synthetic lethality partner inhibitors; targeting of KRAS membrane association and associated metabolic rewiring; autophagy inhibitors; downstream inhibitors; and immunotherapies and …

The Association Between Time Spent On Screens And Reading With Myopia, Premyopia And Ocular Biometric And Anthropometric Measures In 6- To 7-Year-Old Schoolchildren In Ireland, Síofra Harrington, Veronica O'Dwyer

Articles

Purpose More time spent on near tasks has consistently been associated with the promotion of myopia. The World Health Organization advises limiting daily screentime to less than 2 h for children aged five and over. This study explored the relationship between time spent on screens and reading/writing with refractive status, ocular biometric and anthropometric factors in 6-to 7-year- olds in Ireland.

Methods Participants were 723 schoolchildren (377 boys [51.8%]), mean age 7.08 (0.45) years. The examination included cycloplegic autorefraction (1% cyclopentolate hydrochloride), ocular biometry (Zeiss IOLMaster), height (cm) and weight (kg). Screentime and reading/writing time were reported by parents/legal guardians …

Creativity, Craftsmanship, And Connection: Large-Format Sculpture Design, Jacqueline L. Puga, Gordon Hoople

The Transdisciplinary STEAM+ Journal

Artistry is a concept that is not usually explored in engineering yet is an invaluable skill that touches everything from product design to systems thinking. This past summer I developed conceptual designs for a large format sculpture that required connecting engineering knowledge with artistic vision. The initial phase required constant inspiration and creativity. The first step was to look at previous sculptures showcased throughout the world, such as at venues like “Burning Man,” to understand the possibilities or limitations of the space provided. Sketching varied and numerous ideas was essential in our design process. Next, we took our favorite ideas …

Integrating Theatre And Biology: How Embodied Performance Can Enhance Empathy Among College Science Students, Annika C. Speer, Begona Echeverria

The Transdisciplinary STEAM+ Journal

In these field notes, we examine the integration of the arts into a 20-person honors biology seminar at UC Riverside “Beyond Science: Being Humane Amid Human Rights Crises.” We held a four-hour workshop to examine the ways in which performance and theatrical storytelling can enhance science learning. The workshop provided a unique avenue for exploring how human activities result in downward consequences including refugee displacement, one of the course objectives. In addition to the workshop, we conducted surveys and a focus group with the students to better understand their experience incorporating the arts into their science class. A key concept …