Digital Commons Network^™

Taking A Load Off: User Perceptions Of Smart Offloading Walkers For Diabetic Foot Ulcers Using The Technology Acceptance Model, M G Finco, Gozde Cay, Myeounggon Lee, Jason Garcia, Elia Salazar, Tze-Woei Tan, David G Armstrong, Bijan Najafi

Center on Aging Staff Publications

People with diabetic foot ulcers (DFUs) are commonly prescribed offloading walkers, but inadequate adherence to prescribed use can be a barrier to ulcer healing. This study examined user perspectives of offloading walkers to provide insight on ways to help promote adherence. Participants were randomized to wear: (1) irremovable, (2) removable, or (3) smart removable walkers (smart boot) that provided feedback on adherence and daily walking. Participants completed a 15-item questionnaire based on the Technology Acceptance Model (TAM). Spearman correlations assessed associations between TAM ratings with participant characteristics. Chi-squared tests compared TAM ratings between ethnicities, as well as 12-month retrospective fall …

Bi-Allelic Tti1 Variants Cause An Autosomal-Recessive Neurodevelopmental Disorder With Microcephaly, Margaux Serey-Gaut, Marisol Cortes, Periklis Makrythanasis, Mohnish Suri, Alexander M R Taylor, Jennifer A Sullivan, Ayat N Asleh, Jaba Mitra, Mohamad A Dar, Amy Mcnamara, Vandana Shashi, Sarah Dugan, Xiaofei Song, Jill A Rosenfeld, Christelle Cabrol, Justyna Iwaszkiewicz, Vincent Zoete, Davut Pehlivan, Zeynep Coban Akdemir, Elizabeth R Roeder, Rebecca Okashah Littlejohn, Harpreet K Dibra, Philip J Byrd, Grant S Stewart, Bilgen B Geckinli, Jennifer Posey, Rachel Westman, Chelsy Jungbluth, Jacqueline Eason, Rani Sachdev, Carey-Anne Evans, Gabrielle Lemire, Grace E Vannoy, Anne O'Donnell-Luria, Frédéric Tran Mau-Them, Aurélien Juven, Juliette Piard, Cheng Yee Nixon, Ying Zhu, Taekjip Ha, Michael F Buckley, Christel Thauvin, George K Essien Umanah, Lionel Van Maldergem, James R Lupski, Tony Roscioli, Valina L Dawson, Ted M Dawson, Stylianos E Antonarakis

Faculty, Staff and Student Publications

Telomere maintenance 2 (TELO2), Tel2 interacting protein 2 (TTI2), and Tel2 interacting protein 1 (TTI1) are the three components of the conserved Triple T (TTT) complex that modulates activity of phosphatidylinositol 3-kinase-related protein kinases (PIKKs), including mTOR, ATM, and ATR, by regulating the assembly of mTOR complex 1 (mTORC1). The TTT complex is essential for the expression, maturation, and stability of ATM and ATR in response to DNA damage. TELO2- and TTI2-related bi-allelic autosomal-recessive (AR) encephalopathies have been described in individuals with moderate to severe intellectual disability (ID), short stature, postnatal microcephaly, and a movement disorder (in the case of …

Effects Of Protein-Coding Variants On Blood Metabolite Measurements And Clinical Biomarkers In The Uk Biobank, Abhishek Nag, Ryan S Dhindsa, Lawrence Middleton, Xiao Jiang, Dimitrios Vitsios, Eleanor Wigmore, Erik L Allman, Anna Reznichenko, Keren Carss, Katherine R Smith, Quanli Wang, Benjamin Challis, Dirk S Paul, Andrew R Harper, Slavé Petrovski

Faculty, Staff and Students Publications

Genome-wide association studies (GWASs) have established the contribution of common and low-frequency variants to metabolic blood measurements in the UK Biobank (UKB). To complement existing GWAS findings, we assessed the contribution of rare protein-coding variants in relation to 355 metabolic blood measurements-including 325 predominantly lipid-related nuclear magnetic resonance (NMR)-derived blood metabolite measurements (Nightingale Health Plc) and 30 clinical blood biomarkers-using 412,393 exome sequences from four genetically diverse ancestries in the UKB. Gene-level collapsing analyses were conducted to evaluate a diverse range of rare-variant architectures for the metabolic blood measurements. Altogether, we identified significant associations (p < 1 × 10

Hyperoxia Disrupts Lung Lymphatic Homeostasis In Neonatal Mice, Nithyapriya Shankar, Shyam Thapa, Amrit Kumar Shrestha, Poonam Sarkar, M Waleed Gaber, Roberto Barrios, Binoy Shivanna

Faculty, Staff and Students Publications

Inflammation causes bronchopulmonary dysplasia (BPD), a common lung disease of preterm infants. One reason this disease lacks specific therapies is the paucity of information on the mechanisms regulating inflammation in developing lungs. We address this gap by characterizing the lymphatic phenotype in an experimental BPD model because lymphatics are major regulators of immune homeostasis. We hypothesized that hyperoxia (HO), a major risk factor for experimental and human BPD, disrupts lymphatic endothelial homeostasis using neonatal mice and human dermal lymphatic endothelial cells (HDLECs). Exposure to 70% O2 for 24–72 h decreased the expression of prospero homeobox 1 (Prox1) and …

The Impact Of Case Management Intervention For Insured Asthma Patients In Louisiana, An Empirical Study, Mohamed Mohamed Ohaiba

LSU Doctoral Dissertations

Asthma is a chronic condition whose symptoms are managed/prevented using medication and interventions. The overarching objective of this study was to evaluate the impact of patients' demographics on case management enrollment and healthcare utilization, as well as to develop machine learning models to predict high-cost patients.

To accomplish these goals, the Man-Whiteness test, the chi-squares test, logistic regression and odds ratios, and machine learning models were implemented. The average cost of the non-enrolled CM group was significantly higher than the enrolled group (p-value .0001). In addition, the non-enrolled groups had considerably more visits to the emergency department than the other …

Adenoviral Gene Therapy For Bladder Cancer, Roland W Herzog, Masataka Suzuki

Faculty, Staff and Students Publications

Enhanced by polyamide surfactant Syn3, intravesical administration of rAd-IFNα2b results in transduction of the virus into the bladder epithelium, resulting in the synthesis and expression of local IFNα2b cytokine. Upon secretion, IFNα2b binds to the IFNα receptor on bladder cancer and other cells, resulting in signaling via the JAK-STAT pathway. A plethora of induced IFN-stimulated genes containing IFN-sensitive response elements that contribute to activation of pathways restrict cancer growth.

Insights Into Pulmonary Phosphate Homeostasis And Osteoclastogenesis Emerge From The Study Of Pulmonary Alveolar Microlithiasis, Yasuaki Uehara, Steven L Teitelbaum, Et Al.

2020-Current year OA Pubs

Pulmonary alveolar microlithiasis is an autosomal recessive lung disease caused by a deficiency in the pulmonary epithelial Npt2b sodium-phosphate co-transporter that results in accumulation of phosphate and formation of hydroxyapatite microliths in the alveolar space. The single cell transcriptomic analysis of a pulmonary alveolar microlithiasis lung explant showing a robust osteoclast gene signature in alveolar monocytes and the finding that calcium phosphate microliths contain a rich protein and lipid matrix that includes bone resorbing osteoclast enzymes and other proteins suggested a role for osteoclast-like cells in the host response to microliths. While investigating the mechanisms of microlith clearance, we found …

Georgia Academy Of Science 2023 Annual Meeting Program, Al Mead, Dominic Desantis, Hasitha Mahabaduge, Samuel Mutiti, Kristine White, Cason Kelley

Georgia Journal of Science

This is the program of the 2023 Annual Meeting of the Georgia Academy of Science.

Changes In Physical Activity During The Covid-19 Pandemic: A Mixed Methods Assessment, Andrew Corbett, Kathryn E. Wilson, Andrew Van Horn, Jessica D. Ayers, Hector Hurmuz, Athena Aktipis

International Journal of Exercise Science

International Journal of Exercise Science 16(5): 327-341, 2023. COVID-19 was declared a global pandemic in March 2020. Resulting containment protocols altered the day-to-day lives of people around the globe, impacting typical physical activity patterns. The purpose of this mixed-method study was to understand how physical activity changes occurred during the first few months of the COVID-19 pandemic. Participants (n = 271) completed a survey including a qualitative item asking for descriptions of how their physical activity had changed, as well as a categorical item asking whether they had become more active, stayed equally as active, or become less active …

The Effect Of A Division 1 Women’S Basketball Strength And Conditioning Protocol On Mental Toughness, Zach Olivan, Jeff Cherubini, Andreas Stamatis Dr.

International Journal of Exercise Science

International Journal of Exercise Science 16(5): 315-326, 2023. Mental toughness (MT) is a popularized term in sports since it has been found to be positively related to performance. Self-assessment is the most common method of MT data collection. In the strength and conditioning (S&C) context, MT research has focused on males with a notable lack of female participants. Division 1 NCAA strength and conditioning coaches (SCC) spend more hours with their athletes during offseason training than any other coach. The purpose of this study was to measure the perceived effectiveness of an off-season S&C training regimen on MT levels of …

Heart Rate Variability As A Neuroautonomic Marker To Assess The Impact Of Karate Training – An Observational Pediatric Study, Puneet Bhattacharya Ms, Sridip Chatterjee, Samiran Mondal, Dilip Roy

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 342-352, 2023. Habitual physical activity improves heart functions and parasympathetic tone; Karate training is considered as a moderate physical activity with rhythmical breathing patternology. Heart rate variability (HRV) is an electrophysiological tool which measures cardio autonomic homeostasis; is used in the present study as an indirect marker to measure neurocognitive development with karate training. The aim of the present study was to find out the impact of regular karate training on cardiac autonomic responses through Heart Rate Variability (HRV) between karate players and age-sex matched active controls. A total of 30 male school-going children …

Comparable Acute Metabolic Responses When Walking With Blood Flow Restriction And Walking With Load Carriage: Implication For Tactical Professionals, Nathan D. Dicks, Sean J. Mahoney, Allison M. Barry, Katie J. Lyman, Kyle J. Hackney

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 304-314, 2023. The current study aimed to investigate exercise with blood flow restriction (BFR) as a low-intensity conditioning strategy in tactical professionals with load carriage. During the low-intensity exercise, researchers examined the acute metabolic responses from low-intensity BFR walking, walking with load carriage, and walking with BFR and load carriage. Twelve healthy adult males (age = 21.8 ± 1.5 yrs, height = 181.3 ± 7.2 cm, body mass = 84.4 ± 11.1 kg and BMI = 25.6 ± 2.6 kg^.m²) completed five bouts of 3-min treadmill walking at 4.8 kmh …

The Process Of The Intergenerational Succession Of Leadership In A Family Business, Bojan Dolar, Roberto Biloslavo

Economic and Business Review

Background and objective: In this paper, we explore first-generation leadership succession in family businesses which, despite extensive literature on the subject, remains insufficiently understood. Our goal is to acquire new knowledge and understanding regarding this phenomenon with a view to making it more effective.

Method: The basis of our research is a qualitative multiple case study that includes six medium-sized manufacturing family businesses. We conducted semi-structured interviews with incumbents, successors and family representatives, and analysed the data obtained using the content analysis method.

Results: The data analysis and interpretation led to a definition of the category “The way ahead: the …

Corruption: A Review Of Issues, Sandra Damijan

Economic and Business Review

This paper provides a historical overview of the concept of corruption, the existing models for studying it, and the main costs that corruption imposes on the economy and society at large. Corruption was first understood as a disturbance of the balance of state power, and later as the immorality of political patronage and favouritism of certain groups. It evolved from the public sphere to the intertwining of the public and private spheres, from a political issue to the intertwining of political and economic issues. The fight against corruption evolved from the maintenance of necessary checks and balances, from moral struggles …

Senior Nutrition - Meeting An Essential Minnesota Need, Khunza Asma, David Beimers

The Chesley Center on Aging

Food insecurity and malnutrition are significant public health concerns among older adults. Over the past two decades, the number of older adults in the U.S. who are food insecure has more than doubled (Ziliak & Gunderson, 2022). During the first year of the COVID-19 pandemic, deaths among older adults due to malnutrition increased in Minnesota (Olson, 2023). Food insecurity among older adults is associated with numerous health issues, isolation, and increased health costs (ACL, 2021).

One prominent strategy to reduce food insecurity among older adults is to directly provide meals to those who may be food insecure. The State of …

Spontaneous Arterial Thrombus And Dissection Associated With Exercise And Exogenous Testosterone Use, Christopher R. Stewart, Cameron G. Hanson, Heather A. Cronovich

Emergency Medicine Articles

Spontaneous lower extremity arterial dissection has been linked to atherosclerotic and non-atherosclerotic causes. A 55-year-old male presented to the emergency department via emergency medical services for a chief complaint of right leg pain. He stated that he was performing leg exercises when he felt a sudden pop in his right leg followed by severe pain. His exam was remarkable for lack of ipsilateral distal popliteal or dorsalis pedis pulse by palpation or doppler. The patient was admitted to a three-year history of non-prescription testosterone injection use along with a history of prior portal vein thrombosis two years prior with anticoagulation …

Private Pete Fights Illiteracy At Fort Ontario: The Men In Charge, Christian Wright, Adrian Mandzy

2023 Celebration of Student Scholarship - Poster Presentations

From June of 1943 to February of 1944, the 1210th Special Training Unit at Fort Ontario in Oswego, New York taught pre-basic military training to thousands of illiterate, slow learning, and non-English-speaking soldiers in the United States Army. The training center at Fort Ontario conducted programs in disciplinary barracks, specialized military, technical, academic and vocational education.

Classification Of Road Objects Using Convolutional Neural Networks, Mann Patel, Heba Elgazzar

2023 Celebration of Student Scholarship - Poster Presentations

Driving is the primary means of transportation for many people around the world. Whether the use is to assist human drivers or create autonomous driving, the use of machine learning can create safer road conditions. Drivers must consider other objects on the road, most commonly other vehicles and pedestrians. These three components, road signs, pedestrians, and vehicles, make up a large majority of objects that a driver will encounter when on the road. This research applies machine learning algorithms, specifically Convolutional Neural Networks (CNN), to classify these road objects. The goal is to create a classification model that can reliably …

College Of Graduate Programs And Honors Studies Newsletter - March 2023, College Of Graduate Programs And Honors Studies, Wright State University

College of Graduate Programs and Honors Studies Newsletter

An eight page newsletter created by the College of Graduate Programs and Honors Studies at Wright State University. This newsletter includes a upcoming events, message from the dean, and more.

The Gazette March 1, 2023, Langston University

LU Gazette, 2020-2029

The student newspaper for Langston University

Statement Of The District Task Force On Jails & Justice Before The Committee On The Judiciary And Public Safety Of The Council Of The District Of Columbia Performance Oversight Hearing For The D.C. Department Of Corrections March 1, 2023, Katherine S. Broderick

D.C. Council Testimony

No abstract provided.

Community Justice Services: Models From Around The World, Lisa Moore

Canadian Forum on Civil Justice

This document examines community justice services. It highlights approaches and models for local justice outreach and legal assistance effectuated by organizations around the world. The organizations profiled in this document all provide legal assistance in some form to underserved, underprivileged, vulnerable, and/or marginalized populations. In many cases, geographic location is an important factor determining who can access legal help, but it is not the only factor or necessarily a prerequisite. Across the diverse community justice services included in this document, legal assistance is provided virtually, in-person, by phone, or in hybrid formats to individuals living within or beyond a given …

Tax Planning Under The Inflation Reduction Act Of 2022, Martin A. Goldberg, James N. Mohs

Accounting Faculty Publications

The Inflation Reduction Act of2022 (the "Act"), signed by President Biden on 8/16/2022, contained an array of tax provisions that should be considered in tax planning for clients.

The Act is a budget reconciliation bill whose origins can be traced back to the American Rescue Plan Act of2021, as well as the American Jobs Plan (AJP) and the American Families Plan (AFP). Each plan contained aspects of tax incentives for green energy construction, conservation, and infrastructure improvements, as well as for healthcare benefits. What we see in the Act is the last iteration of these developing tax incentives.

The Act …

Overcoming The Impostor Phenomenon: Exploring The Strategies Special Education Charter School Leaders Used To Cope During The Covid-19 Pandemic, Damaris Ocasio Owens

Dissertations

Purpose: The purpose of this descriptive mixed method study was to explore and describe the coping skills used to overcome the nine behavioral characteristics by special education charter school leaders who identified as experiencing impostor phenomenon (IP) by the Clance Impostor Phenomenon Scale (Clance,1985), while leading the transition to distance learning in response to the COVID-19 pandemic. Methodology: This descriptive mixed-methods research design used quantitative and qualitative data to identify special education leaders with IP and explore the coping skills they used during distance learning. The first phase of the study was a quantitative 20-question survey, the CIPS, used to …

Omss Newsletter, March 1 2023, Office Of Multicultural Student Success

OMSS Newsletter

No abstract provided.

Daily Announcements March 2023, Wofford College. Office Of Marketing And Communications

Communications Office Daily Announcements

No abstract provided.

Pan-Arctic Soil Moisture Control On Tundra Carbon Sequestration And Plant Productivity, Donatella Zona, Peter M. Lafleur, Koen Hufkens, Beniamino Gioli, Barbara Bailey, George Burba, Eugénie S. Euskirchen, Jennifer D. Watts, Kyle A. Arndt, Mary Farina, John S. Kimball, Martin Heimann, Mathias Göckede, Martijn Pallandt, Torben R. Christensen, Mikhail Mastepanov, Efrén López-Blanco, Albertus J. Dolman, Roisin Commane, Charles E. Miller, Josh Hashemi, Lars Kutzbach, David Holl, Julia Boike, Christian Wille, Torsten Sachs, Aram Kalhori, Elyn R. Humphreys, Oliver Sonnentag, Gesa Meyer, Gabriel H. Gosselin, Philip Marsh, Walter C. Oechel

Daugherty Water for Food Global Institute: Faculty Publications

Long-term atmospheric CO₂ concentration records have suggested a reduction in the positive effect of warming on high-latitude carbon uptake since the 1990s. A variety of mechanisms have been proposed to explain the reduced net carbon sink of northern ecosystems with increased air temperature, including water stress on vegetation and increased respiration over recent decades. However, the lack of consistent long-term carbon flux and in situ soil moisture data has severely limited our ability to identify the mechanisms responsible for the recent reduced carbon sink strength. In this study, we used a record of nearly 100 site-years of eddy covariance …

Young Professionals, Lehigh Valley Health Network

Young Professionals

No abstract provided.

We Keep Us Safe, Venmo Doesn't: The Impact On Peer-To-Peer Payment Apps On Mutual Aid And Community Organizing, Meghan G. Rankins

North Carolina Banking Institute

No abstract provided.

Molecular Peptide Grafting As A Tool To Create Novel Protein Therapeutics, Anton A. Komar

Biological, Geological, and Environmental Faculty Publications

The study of peptides (synthetic or corresponding to discrete regions of proteins) has facilitated the understanding of protein structure-activity relationships. Short peptides can also be used as powerful therapeutic agents. However, the functional activity of many short peptides is usually substantially lower than that of their parental proteins. This is (as a rule) due to their diminished structural organization, stability, and solubility often leading to an enhanced propensity for aggregation. Several approaches have emerged to overcome these limitations, which are aimed at imposing structural constraints into the backbone and/or sidechains of the therapeutic peptides (such as molecular stapling, peptide backbone …