Digital Commons Network^™

A Narrative Review Of The Lesser Known Medications For Treatment Of Restless Legs Syndrome And Pathogenetic Implications For Their Use, Paul Gerardo Yeh, Karen Spruyt, Lourdes M. Delrosso, Arthur S. Walters

Physician Assistant Studies Faculty Publications

Background: There are several well-known treatments for Restless Legs Syndrome (RLS), including dopamine agonists (pramipexole, ropinirole, rotigotine), anticonvulsants (gabapentin and its analogs, pregabalin), oral or intravenous iron, opioids and benzodiazepines. However, in clinical practice, treatment is sometimes limited due to incomplete response or side effects and it is necessary to be aware of other treatment options for RLS, which is the purpose of this review.

Methods: We performed a narrative review detailing all of the lesser known pharmacological treatment literature on RLS. The review purposefully excludes well-established, well-known treatments for RLS which are widely accepted as treatments for …

Misrepresentation And Contract, Gregory Klass

Georgetown Law Faculty Publications and Other Works

Contract theorists naturally focus on the duty to perform. This chapter argues they should also pay attention to duties of candor in the contracting context. The most obvious example of such duties can be found in the misrepresentation defenses, which aim to ensure that contractual undertakings are sufficiently voluntary and to allocate the costs of defective consent. But other laws of deception, such as the torts of negligent misrepresentation and deceit, are also integral to the law of contracts. Separate liability in tort for both pre- and post-formation misrepresentations helps parties who mistrust one another determine whether an exchange is …

The Death Of Bilal Al-Sudani And Its Impact On Islamic State Operations, Tricia Bacon, Austin C. Doctor

Reports, Projects, and Research

IN LATE JANUARY, the U.S. military conducted an operation in a cave complex located in northern Somalia that resulted in the death of Bilal al-Sudani, a key operative and facilitator for the Islamic State. The raid provides further evidence that Africa has become the “epicenter” for Islamic State activity in particular and for the global Sunni jihadist movement more broadly. Certainly, counterterrorism has been downgraded as a U.S. national security priority. Yet, the use of American military personnel in a risky ground-based operation reflects al-Sudani’s importance as well as the United

[Excerpt From] Beyond Burnout: Overcoming Stress In Nursing & Healthcare For Optimal Health & Well-Being (2nd Ed.), Suzanne Waddill-Goad

Sigma Publications: Book Excerpts

This item record pertains to an excerpt from Beyond Burnout, Second Edition, which is provided free of charge by the publisher.

About this book:

Healthcare professions typically attract those who give deeply of themselves to make a positive difference in others' lives. But that giving can come at a significant price: burnout. While the healthcare vocation offers myriad options in work settings and career paths, it can also involve tremendous amounts of stress because of long shifts, mental and physical exhaustion, patient challenges, and regulatory changes. When stress and fatigue overtake a healthcare provider's ability to adequately cope with …

Pharmacotherapeutic Challenges For Treating The Baby Boomer Cohort, Scott P. Pelok

Faculty Scholarship

As the baby boomer cohort ages, they have an ever‐increasing number of comorbidities and associated poly‐pharmaceutical treatment needs. The challenge for healthcare providers is to stay current of advancements in providing for this aging population. Baby boomers can expect a longer life expectancy than any previous generation. Yet, longevity has not correlated with better health. This cohort is noted for being goal driven and more self‐assured than younger generations. They are resourceful and will often attempt to fix things themselves, including their healthcare. They believe hard work deserves justifiable rewards and relaxation. These beliefs have resulted in baby boomers utilizing …

Combining Targeted Dna Repair Inhibition And Immune-Oncology Approaches For Enhanced Tumor Control, Kyle Concannon, Benjamin B Morris, Carl M Gay, Lauren A Byers

Faculty, Staff and Student Publications

Targeted therapy and immunotherapy have revolutionized cancer treatment. However, the ability of cancer to evade the immune system remains a major barrier for effective treatment. Related to this, several targeted DNA-damage response inhibitors (DDRis) are being tested in the clinic and have been shown to potentiate anti-tumor immune responses. Seminal studies have shown that these agents are highly effective in a pan-cancer class of tumors with genetic defects in key DNA repair genes such as BRCA1/2, BRCA-related genes, ataxia telangiectasia mutated (ATM), and others. Here, we review the molecular consequences of targeted DDR inhibition, from tumor cell death to increased …

Non-Invasive Neuromodulation Methods To Alleviate Symptoms Of Huntington's Disease: A Systematic Review Of The Literature, Lijin Jose, Lais Bhering Martins, Thiago M Cordeiro, Keya Lee, Alexandre Paim Diaz, Hyochol Ahn, Antonio L Teixeira

Faculty, Staff and Student Publications

Huntington's disease (HD) is a progressive and debilitating neurodegenerative disease. There is growing evidence for non-invasive neuromodulation tools as therapeutic strategies in neurodegenerative diseases. This systematic review aims to investigate the effectiveness of noninvasive neuromodulation in HD-associated motor, cognitive, and behavioral symptoms. A comprehensive literature search was conducted in Ovid MEDLINE, Cochrane Central Register of Clinical Trials, Embase, and PsycINFO from inception to 13 July 2021. Case reports, case series, and clinical trials were included while screening/diagnostic tests involving non-invasive neuromodulation, review papers, experimental studies on animal models, other systematic reviews, and meta-analyses were excluded. We have identified 19 studies …

Neoadjuvant-Adjuvant Or Adjuvant-Only Pembrolizumab In Advanced Melanoma, Sapna P Patel, Megan Othus, Yuanbin Chen, G Paul Wright, Kathleen J Yost, John R Hyngstrom, Siwen Hu-Lieskovan, Christopher D Lao, Leslie A Fecher, Thach-Giao Truong, Jennifer L Eisenstein, Sunandana Chandra, Jeffrey A Sosman, Kari L Kendra, Richard C Wu, Craig E Devoe, Gary B Deutsch, Aparna Hegde, Maya Khalil, Ankit Mangla, Amy M Reese, Merrick I Ross, Andrew S Poklepovic, Giao Q Phan, Adedayo A Onitilo, Demet G Yasar, Benjamin C Powers, Gary C Doolittle, Gino K In, Niels Kokot, Geoffrey T Gibney, Michael B Atkins, Montaser Shaheen, James A Warneke, Alexandra Ikeguchi, Jose E Najera, Bartosz Chmielowski, Joseph G Crompton, Justin D Floyd, Eddy Hsueh, Kim A Margolin, Warren A Chow, Kenneth F Grossmann, Eliana Dietrich, Victor G Prieto, Michael C Lowe, Elizabeth I Buchbinder, John M Kirkwood, Larissa Korde, James Moon, Elad Sharon, Vernon K Sondak, Antoni Ribas

Faculty, Staff and Student Publications

BACKGROUND: Whether pembrolizumab given both before surgery (neoadjuvant therapy) and after surgery (adjuvant therapy), as compared with pembrolizumab given as adjuvant therapy alone, would increase event-free survival among patients with resectable stage III or IV melanoma is unknown.

METHODS: In a phase 2 trial, we randomly assigned patients with clinically detectable, measurable stage IIIB to IVC melanoma that was amenable to surgical resection to three doses of neoadjuvant pembrolizumab, surgery, and 15 doses of adjuvant pembrolizumab (neoadjuvant-adjuvant group) or to surgery followed by pembrolizumab (200 mg intravenously every 3 weeks for a total of 18 doses) for approximately 1 year …

Leveraging Digital Technology To Support Pregnant And Early Parenting Women In Recovery From Addictive Substances: A Scoping Review, Phyllis Raynor, Cynthia F. Corbett Phd, Rn, Faan, Delia West, D'Arion Johnston, Kacey Eiche, Alain Litwin, Constance Guille, Ron Prinz

Publications

Little is known about digital health interventions used to support treatment for pregnant and early parenting women (PEPW) with substance use disorders (SUD).METHODS: Guided by the Arksey and O'Malley's Scoping Review Framework, empirical studies were identified within the CINAHL, PsycInfo, PubMed, and ProQuest databases using subject headings and free-text keywords. Studies were selected based on a priori inclusion/exclusion criteria, and data extraction and descriptive analysis were performed. RESULTS: A total of 27 original studies and 30 articles were included. Varying study designs were used, including several feasibility and acceptability studies. However, efficacious findings on abstinence and other clinically important outcomes …

Initial Impacts Of The Covid-19 Pandemic On Australian Fisheries Production, Research Organisations And Assessment: Shocks, Responses And Implications For Decision Support And Resilience, Emily M. Ogier, David C. Smith, Sian Breen, Caleb Gardner, Daniel J. Gaughan, Harry K. Gorfine, Alistair J. Hobday, Natalie Moltschaniwskyj, Ryan Murphy, Thor Saunders, Michael Steer, James Woodhams

Fisheries Research Articles

Australia’s fisheries have experience in responding individually to specific shocks to stock levels (for example, marine heatwaves, floods) and markets (for example, global financial crisis, food safety access barriers). The COVID-19 pandemic was, however, novel in triggering a series of systemic shocks and disruptions to the activities and operating conditions for all Australia’s commercial fisheries sectors including those of the research agencies that provide the information needed for their sustainable management. While these disruptions have a single root cause—the public health impacts and containment responses to the COVID-19 pandemic—their transmission and effects have been varied. We examine both the impacts …

The Cowl - V. 87 N. 13 - March 2, 2023

The Cowl

The Cowl - student newspaper of Providence College. Vol. 87 No. 13 - March 2, 2023. 20 pages.

Increasing Housing Stability Through State-Funded Community Mediation Delivered By The Massachusetts Housing Mediation Program (Hmp) In Fy2022, Madhawa Palihapitiya, David Sulewski, Karina Zeferino, Jarling Ho

Massachusetts Office of Public Collaboration Publications

This report presents findings and recommendations from an evaluation of the Massachusetts Housing Mediation Program (HMP) administered by the MA Office of Public Collaboration (MOPC) at the University of Massachusetts Boston in partnership with 11 Community Mediation Centers (Centers). The program is funded by the Commonwealth of Massachusetts and implemented in partnership with the Department of Housing and Community Development (DHCD). The program was initially part of the Governor’s Eviction Diversion Initiative (EDI), which ended in the latter half of FY2022 and is continuing as an intervention to support housing stability. The evaluation was conducted by MOPC’s research unit comprised …

Applied Machine Learning In Development Of Geospatial Information Tools For Sustainable Groundwater Management, Saul Gallegos Ramirez

Theses and Dissertations

Groundwater plays an important role in sustainable water resource management. Globally, the development of groundwater resources for irrigation provides a stable water source and enhances food security. However, developing groundwater resources is difficult, requiring the collection, synthesis, analysis, and dissemination of information about groundwater in an accessible, effective manner so decision makers have the knowledge and tools to implement sustainable management strategies. In this dissertation, I present solutions to assist with the paucity of groundwater data. The first problem I explore is extending the Palmer Drought Severity Index to near present day. This dataset is crucial to current groundwater imputation …

Jahaca Acquisitions, Llc V. Van Oss

All Decisions

No abstract provided.

Benthic Habitat Mapping Of Mountain Top Bank Within The Northern Gulf Of Mexico Through Integrated Geophysical And Visual Data Analysis, Bethany Pertain

Master's Theses

Mesophotic coral ecosystems (MCEs) are among the seafloor ecosystems that have been poorly studied throughout the world’s oceans, but they are a vital and diverse ecosystem that should be prioritized for future mapping and ecological studies. Priority should be given to them because they possess natural, social, and economic values, and face a variety of threats, all of which, if not better understood will result in the loss of this unique ecosystem. Insights into these ecosystems, among other deep-sea environments, are lacking due to difficulty accessing them, inherent lag between data collection by an autonomous system and observation by a …

Patterns Of Care Partner Communication For Persons Living With Dementia In The Emergency Department, Adrian D. Haimovich, Aidan Gilson, Evangeline Gao, Ling Chi, Cameron J. Gettel, Mara Schonberg, Ula Hwang, Richard A. Taylor

Journal of Geriatric Emergency Medicine

Abstract

Background:

Nearly half of all persons living with dementia (PLwD) will visit the emergency department (ED) in any given year and ED visits by PLwD are associated with short-term adverse outcomes. Care partner engagement is critical in the care of PLwD, but little is known about their patterns of communication with ED clinicians.

Methods:

We performed a retrospective electronic health record (EHR) review of a random sampling of patients ≥ 65 years with a historical diagnosis code of dementia who visited an ED within a large

regional health network between 1/2014 and 1/2022. ED notes within the EHRs were …

Factors Influencing The Use Of Multiple Hiv Prevention Services Among Transport Workers In A City In Southwestern Uganda, Benjamin Betunga, Phionah Atuhaire, Catherine Nakasiita, Christa Kanyamuneza, Proscovia Namiiro, Joseph Tugume, Matovu Hairat, Ahmed Sarki, Benedicto Mugabi, Birungi Lilian, Richard Mugisha Richard Mugisha, Edward Kumakech, John Baptist Asiimwe

School of Nursing & Midwifery, East Africa

The use of multiple HIV prevention services has been found to decrease the risk of acquiring HIV when tailored to individuals at risk of HIV exposure, including transport workers. Therefore, we assessed the uptake of multiple HIV prevention services (≥2) and associated factors among transport workers in a city in Southwestern Uganda. This cross-sectional study comprised motorcycle taxi riders, motor vehicle and truck drivers, aged 18 to 55 years who were selected and responded to an interviewer-administered questionnaire, between November 2021 and February 2022. Data was analyzed using descriptive statistical and modified Poisson regression analyses. Out of 420 participants, 97.6% …

Myo19 Tethers Mitochondria To Endoplasmic Reticulum-Associated Actin To Promote Mitochondrial Fission, Stephen M. Coscia, Cameron P. Thompson, Qing Tang, Elana E. Baltrusaitis, Joseph A. Rhodenhiser, Omar A. Quintero, E. Michael Ostap, Melike Lakadamyali, Erika L. Holzbaur

Biology Faculty Publications

Mitochondrial homeostasis requires a dynamic balance of fission and fusion. The actin cytoskeleton promotes fission, and we found that the mitochondrially localized myosin, myosin 19 (Myo19), is integral to this process. Myo19 knockdown induced mitochondrial elongation, whereas Myo19 overexpression induced fragmentation. This mitochondrial fragmentation was blocked by a Myo19 mutation predicted to inhibit ATPase activity and strong actin binding but not by mutations predicted to affect the working stroke of the motor that preserve ATPase activity. Super-resolution imaging indicated a dispersed localization of Myo19 on mitochondria, which we found to be dependent on metaxins. These observations suggest that Myo19 acts …

Action-Logics Of Veterans Health Administration Magnet Nurse Executives And Their Practice Of Supporting Nurses To Speak Up, Bonnie R. Pierce

Dissertations

Health care organizations typically have a hierarchical structure, with physicians dominant and nurses subordinate. The challenge to open and honest communication between doctors and nurses is real, and communication errors contribute significantly to undesirable patient outcomes. Nurse executives (NEs) have a responsibility to help lead transformation of health care organizations to support nurses to speak up and communicate all critical information.

NEs are challenged to improve safety and quality, decrease costs and increase access to care. Combining health care expertise with business ability can support these goals. Rooke and Torbert found correlations between successful business leaders and postconventional action-logics, or …

The Montclarion, March 2, 2023, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

Immigration Related Trauma Among Haitians: Barriers To Treatment And The Role Of Faith In Creating Resiliency, Sandra Garcon Degerville

Doctoral Dissertations and Projects

The topic of this writer’s dissertation is immigration-related trauma among Haitians, barriers to treatment, and the role of faith in creating resiliency. The purpose of this qualitative push and pull hermeneutic phenomenological study is to understand the lived experiences of people who have immigrated to the United States (US). To better understand these lived experiences, it is imperative to also examine the experiences of Haitian immigrants from the gateway countries of Brazil, Chile, Canada, and the Dominican Republic. It is known that a number of Haitians have entered the US directly (legally or illegally) and a great many entered by …

A Quantitative Analysis Of The Views And Perceptions Of Building Leaders On Discipline And Special Education For Urban Students, Dementred T. Young

Doctoral Dissertations and Projects

This dissertation involved summarizing and critically evaluating principals’ views on students who have been traumatized and the treatment these students receive as a result of these perceptions. The main focus was to ascertain whether administrators’ upbringing has a mediating effect on the treatment of students being educated in an urban community. The central question focused on the views and perceptions of building leaders raised in urban, suburban, or rural areas and the impact of their perception of urban students who have experienced trauma. Sub-questions were designed to uncover the relationship between the building administrator’s life experiences and perceptions of disciplinary …

Grief After Perinatal Loss: A Descriptive Phenomenological Study, Marlena Jalise Baxter-Dunn

Doctoral Dissertations and Projects

The purpose of this descriptive phenomenological study was to describe the experiences of grief, coping, and spiritual crisis in the lives of women who faced perinatal loss. The theory guiding this study was Pargament’s Theory of Religious Coping, as it explains the role of religious coping in the potential development of complicated grief and complicated spiritual grief. One central research question guided this study: how do women with religious/spiritual beliefs describe their lived experience of grief from perinatal loss? The sample size for the study was eight women with religious/spiritual beliefs who experienced perinatal loss. Data were collected using an …

School Connectedness In American Style Comprehensive And European Style Tracking Secondary Schools, Diana Csaki

Doctoral Dissertations and Projects

Schools are often considered a community nested within a community. A caring school environment contributes to community and belongingness among students. School connectedness, the belief held by students that adults and peers in the school care about their learning and about them as individuals, is viewed as a construct comprising affective, behavioral and cognitive dimensions. School connectedness among students in the United States has been shown as a predictor of adolescent health and academic outcomes with positive feelings of school connectedness linked to positive outcomes. School connectedness research often centers on children and early adolescents and less over the high …

A Phenomenological Study Examining The Collaborative Community Experiences Of Veteran Special Educators, Jennifer Boyd

Doctoral Dissertations and Projects

This phenomenological study aimed to examine and describe the experiences of veteran special education (SPED) teachers in rural southwest Georgia school districts regarding their collaborative community network experiences within the field. Granovetter’s (1973) social network theory (SNT) encompasses critical concepts of belongingness and connection about job satisfaction over time and throughout educational contexts and guided this study. A phenomenological approach involving teacher interviews, a focus group, and journal prompts was used to examine the experiences of SPED teachers on their social networks. Eleven veteran SPED teachers were interviewed using open-ended interview scripts developed to target the central research question. Convenience …

From Dropout To Doctorate: A Phenomenology Of The Self-Determination Of Individuals Who Persisted To Completion, Nancy Catherine Hamilton

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to describe the lived experiences of former high school dropouts in the Continental United States who self-determined to persist to doctoral degree attainment. The theory that guided this study was the self-determination theory with support from the self-efficacy theory and adult learning theory. These three theories framed this study, which sought to discover the motivating factors, life influences, and perseverance required of former high school dropouts who determined to re-enter academia and pursue an education to the doctoral level. The problem this study sought to address was the need to discover the …

The Impact Of Pre-Hire Fitness Scores On Resilience And Burnout Among New Castle County Patrol-Level Police Officers, Eugene Joseph Reid

Doctoral Dissertations and Projects

This study seeks participation from patrol-level officers with at least two years’ experience in the New Castle County Police Department in Delaware (n=134) and requests that they respond to two questionnaires measuring resilience and job burnout: the 25-item Resilience Scale and the Maslach Burnout Inventory. Additionally, participants are asked to self-report their pre-hire fitness scores. Police officers are repeatedly exposed to trauma, which has negative mental and physical consequences, often leading to extreme stress, fatigue, and emotional imbalance. Repeated trauma also impacts physical fitness, which is critical for not only physical and mental health but also work performance, especially for …

Finding The Missing Pieces: A Phenomenological Study Of Elementary Teachers' Experiences With Student Suicidality, Dionna Lashawn Doneghy

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to explore elementary school teachers’ experiences with student suicidality in North Georgia. The first theory guiding this study was the Interpersonal theory of suicide, developed by Thomas Joiner to explain how risk factors of suicide interact to better understand who is most likely to make suicide attempts. Specifically, it proposes that when a sense of social alienation and perceived burdensomeness occur simultaneously, an individual begins to desire death. The second theory guiding this research was the three-step theory of suicide developed by E. David Klonsky and Alexis May. This theory posits that …

The Effects Of Positive Leadership Behaviors And Organizational Justice On Employee Engagement, Felicia A. Long

Doctoral Dissertations and Projects

Increasing employee engagement has been a challenge for many organizations in recent years, especially in America. Most research has focused on organizational factors related to engagement; few have explored interactional issues from a positive leadership perspective. This study sought to contribute to research on engagement by exploring its relationship with fairness and trust This study viewed fairness from the perspective interactional justice, as defined by the interactional justice scale of Colquitt’s Organizational Justice Scale (OJS). This study also viewed trust from the perspective of leader trustworthiness, a positive leadership attribute. The purpose of this quantitative study was to examine the …

The Clapham Saints: A Correlational Study Between A Christian's Level Of Commitment To The Christian Faith And Their Engagement In Human Trafficking Political Matters, Charles L. Carpenter

Doctoral Dissertations and Projects

The purpose of this correlational study is to determine if a relationship exists between the commitment level of Christians who attend a church in the Northern Shenandoah Valley portion of Virginia that falls under the covering of Abba’s House––Chattanooga, Tennessee as assessed by the Belief into Action (BIAC) scale, and their level of engagement in human trafficking political matters, as assessed by the Human Trafficking Political Engagement (HTPE) scale. Every year, millions of individuals become victims of human trafficking. Human trafficking victims are created in God's image, leaving Christians obligated to protect them. William Wilberforce and the Clapham Saints’ political …