Digital Commons Network^™

Guest Column: Paraquat And The Deliberate Production Of Ignorance, Amit Ray, Earl Ray Dorsey

Articles

The article examines how paraquat's manufacturer used "agnotology" - the deliberate production of ignorance for commercial gain - to hide evidence linking the herbicide to Parkinson's disease. Despite decades of toxic effects documented in company studies, the company expanded sales while allegedly suppressing research and discrediting scientists investigating paraquat dangers.

Occupational Therapists' Experience Of Using Home Adaptation And Assistive Products As Interventions For Older Individuals And Persons With Disabilities In Thailand, Peeradech Thichanpiang, Veerawat Sansri, Surachart Thongchoomsin, Sutinun Juntorn, Thitiya Wangkawan, Supatida Sorasak, Phichaya Baramee, Kannika Permpoonputtana, Chirathip Thawisuk, Chutikorn Nopparat, Anuchart Kaunnil Corresponding Author

The Qualitative Report

As Thailand becomes an aged society it is important to promote advancements in geriatric medicine to provide the best care for older individuals. The right assistive facilities and household mobility equipment are essential for everyday activities. The use of home adaptations and assistive products can maximize the quality of life for older individuals and make life more convenient for those with disabilities. This study aimed to investigate the experience of occupational therapists, using home adaptations and assistive products. An individual interview was conducted with eight occupational therapists who worked at regional hospitals and centers of excellence throughout Thailand using a …

Why Interstate Child Care Scholarship Policy Choices Matter In The Upper Valley: "You Can Only Charge The Families So Much", Sarah Boege, Jess Carson

Carsey Publications

In this brief, the authors explore how state-level decisions in New Hampshire and Vermont manifest in the early childhood education and care sector, through the lens of the interstate Upper Valley region. They demonstrate the significant differences in the reach and adequacy of child care financial assistance programs (“child care scholarships”) across state lines, with Vermont’s program setting family income eligibility thresholds higher and delivering higher-value reimbursements to child care providers than New Hampshire’s program. While scholarships are key for widening low-income families’ access to high quality care, they are not a panacea. Not all eligible families participate in child …

Changing Child Care Supply In New Hampshire And Vermont’S Upper Valley, Jess Carson, Sarah Boege

Carsey Publications

In this brief, authors Jess Carson and Sarah Boege describe changes in the early childhood education and care landscape of Grafton and Sullivan Counties in New Hampshire and Orange and Windsor Counties in Vermont, collectively known as the Upper Valley. The authors find that the Upper Valley lost 25 regulated child care providers serving children under age 5 between 2017 and 2021. However, with closure rates twice as high among family-based providers than among center-based providers and some new providers opening, the net number of slots has remained relatively stable (5,169 slots in 2021). The overall effect has been to …

Assessing Risk Factors For 90-Day Emergency Department Visits Status-Post Index Total Knee Arthroplasty: A Retrospective Case Control Study, Ian Penvose, Helen E. Huetteman, Phil Vartanyan, James Feng, Robert Runner, Drew Douglas Moore, Mark S. Karadsheh

Conference Presentation Abstracts

INTRODUCTION: With the increasing adoption of value-based healthcare initiatives in total knee arthroplasty (TKA), a greater emphasis has been placed on implementing cost-saving measures while maintaining or improving quality of care. One area of interest has been postoperative ED visits. Here we evaluate potential risk factors for 90-day ED visits. METHODS: This is a case control study from a large, tertiary, private, academic institution. All primary TKAs between 7/1/2013 to 12/31/2017 were obtained retrospectively from a prospective institutional database utilized for contribution to a state-wide joint arthroplasty database. All patient charts were subsequently verified and reviewed for all-cause 90-day ED …

More Questions Than Answers To The Diagnosis And Management Of Cauda Equina Syndrome—Authors’ Reply, Julie Woodfield, Ingrid Hoeritzauer, Aimun A.B. Jamjoom, Simon Lammy, Savva Pronin, Cathal J. Hannan, Anna Watts, Laura Hughes, Richard D.C. Moon, Holly Roy, Michael T.C. Poon, Paul Thorpe, Nisaharan Srikandarajah, Andreas K. Demetriades, Niall Eames, Philip J. Sell, Patrick F.X. Statham

Peninsula Medical School

No abstract provided.

Profiling Cognitive–Motor Interference In A Large Sample Of Persons With Progressive Multiple Sclerosis And Impaired Processing Speed: Results From The Cogex Study, R. Veldkamp, M. D’Hooge, B. M. Sandroff, J. Deluca, D. Kos, A. Salter, A. Feinstein, M. P. Amato, G. Brichetto, J. Chataway, R. Farrell, N. D. Chiaravalloti, U. Dalgas, M. Filippi, J. Freeman, R. W. Motl, C. Meza, M. Inglese, M. A. Rocca, G. Cutter, P. Feys

School of Health Professions

BACKGROUND: Performing cognitive-motor dual tasks (DTs) may result in reduced walking speed and cognitive performance. The effect in persons with progressive multiple sclerosis (pwPMS) having cognitive dysfunction is unknown. OBJECTIVE: To profile DT-performance during walking in cognitively impaired pwPMS and examine DT-performance by disability level. METHODS: Secondary analyses were conducted on baseline data from the CogEx-study. Participants, enrolled with Symbol Digit Modalities Test 1.282 standard deviations below normative value, performed a cognitive single task ([ST], alternating alphabet), motor ST (walking) and DT (both). Outcomes were number of correct answers on the alternating alphabet task, walking speed, and DT-cost (DTC: decline …

Caregiver Presence In A Home-Based Cardiac Rehabilitation Programme Improves The Health-Related Quality Of Life Of Patients With Heart Failure, Miriam C. Noonan, Julia Frost, Hasnain M. Dalal, Rod S. Taylor

School of Health Professions

Abstract Rehabilitation Enablement in CHronic Heart Failure (REACH-HF) is a home-based cardiac rehabilitation intervention designed for patients with heart failure and their caregivers. We present a pooled analysis of patients > 18 years with a confirmed diagnosis of HF recruited to two REACH-HF randomised controlled trials. Where identified by patients and they consented to participate, caregivers were randomly assigned with patients to receive the REACH-HF intervention plus usual care or usual care alone. Our analysis demonstrated that compared to control group, the REACH-HF group had a greater gain in their disease-specific health related quality of life at follow up.

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Preparation And Synergy Of Supported Ru0 And Pd0 For Rapid Chlorate Reduction At Ph 7, Jinyu Gao, Shaohua Xie, Fudong Liu, Jinyong Liu

Faculty, Staff and Student Publications

Chlorate (ClO3–) is a common water pollutant due to its gigantic scale of production, wide applications in agriculture and industry, and formation as a toxic byproduct in various water treatment processes. This work reports on the facile preparation, mechanistic elucidation, and kinetic evaluation of a bimetallic catalyst for highly active ClO3– reduction into Cl–. Under 1 atm H2 and 20 °C, PdII and RuIII were sequentially adsorbed and reduced on a powdered activated carbon support, affording Ru0–Pd0/C from scratch within only 20 min. The Pd0 particles significantly accelerated the reductive immobilization of RuIII as >55% dispersed Ru0 outside Pd0. At …

Multifaceted Role For P53 In Pancreatic Cancer Suppression, Stephano S Mello, Brittany M Flowers, Pawel K Mazur, James J Lee, Fabian Müller, Sarah K Denny, Sofia Ferreira, Kathryn Hanson, Seung K Kim, William J Greenleaf, Laura D Wood, Laura D Attardi

Faculty, Staff and Student Publications

The vast majority of human pancreatic ductal adenocarcinomas (PDACs) harbor TP53 mutations, underscoring p53's critical role in PDAC suppression. PDAC can arise when pancreatic acinar cells undergo acinar-to-ductal metaplasia (ADM), giving rise to premalignant pancreatic intraepithelial neoplasias (PanINs), which finally progress to PDAC. The occurrence of TP53 mutations in late-stage PanINs has led to the idea that p53 acts to suppress malignant transformation of PanINs to PDAC. However, the cellular basis for p53 action during PDAC development has not been explored in detail. Here, we leverage a hyperactive p53 variant-p5353,54-which we previously showed is a more robust PDAC suppressor than …

Social Science Researchers' Perceptions Of Inclusive Research Practices For Transgender And Gender Diverse Communities, Christen Seyl

Honors Program: Senior Projects (Public)

Social sciences research has historically excluded or marginalized of transgender and gender diverse (TGD) people. Although TGD affirming research materials can help improve relationships with TGD communities, these sorts of materials are not standard practice. The present study aimed to determine what factors influence social science researchers’ (SSR) willingness to incorporate affirming practices into their research. We hypothesized that more culturally competent SSR will view TGD affirming research materials as more affirming and be more willing to use similar materials in their work. In this study, SSR (n = 32) viewed and rated affirmation and willingness to use five affirming …

A Global Phylogenomic Analysis Of The Shiitake Genus Lentinula, Sean Sierra-Patev, Byoungnam Min, Miguel Naranjo-Ortiz, Brian Looney, Zachary Konkel, Jason C. Slot, Yuichi Sakamoto, Jacob L. Steenwyk, Antonis Rokas, Juan Carro, Susana Camarero, Patricia Ferreira, Gonzalo Molpeceres, Francisco J. Ruiz-Dueñas, Ana Serrano, Bernard Henrissat, Elodie Drula, Karen W. Hughes, Juan L. Mata, Noemia Kazue Ishikawa, Ruby Vargas-Isla, Shuji Ushijima, Chris A. Smith, John Donoghue, Steven Ahrendt, William Andreopoulos, Guifen He, Kurt Labutti, Anna Lipzen, Vivian Ng, Robert Riley, Laura Sandor, David Hibbett

Biology

Lentinula is a broadly distributed group of fungi that contains the cultivated shiitake mushroom, L. edodes. We sequenced 24 genomes representing eight described species and several unnamed lineages of Lentinula from 15 countries on four continents. Lentinula comprises four major clades that arose in the Oligocene, three in the Americas and one in Asia–Australasia. To expand sampling of shiitake mushrooms, we assembled 60 genomes of L. edodes from China that were previously published as raw Illumina reads and added them to our dataset. Lentinula edodes sensu lato (s. lat.) contains three lineages that may warrant recognition as species, one including …

A Nationwide Study Of The “July Effect” Concerning Postpartum Hemorrhage And Its Risk Factors At Teaching Hospitals Across The United States, Zahra Shahin, Gulzar H. Shah, Bettye Apenteng, Kristie Cason Waterfield, Hani M. Samawi

Health Policy & Community Health: Faculty Publications

Objective To assess the “July effect” and the risk of postpartum hemorrhage (PPH) and its risk factors across the U.S. teaching hospitals. Method This study used the 2018 Nationwide Inpatient Sample (NIS) and included 2,056,359 of 2,879,924 single live-birth hospitalizations with low-risk pregnancies across the U.S. teaching hospitals. The International Classification of Diseases, Tenth Revision (ICD-10) from the American Academy of Professional Coders (AAPC) medical coding was used to identify PPH and other study variables. Multivariable logistic regression models were used to compare the adjusted odds of PPH risk in the first and second quarters of the academic year vs. …

Stiff Knee Gait Disorders As Neuromechanical Consequences Of Spastic Hemiplegia In Chronic Stroke, Sheng Li

Faculty, Staff and Student Publications

Stiff knee gait (SKG) is defined as decreased knee flexion during the swing phase. It is one of the most common gait disorders following stroke. Knee extensor spasticity is commonly accepted as the primary cause. Clinical management has focused on the reduction in knee extensor spasticity. Recent advances in understanding of post-stroke hemiplegic gait suggest that SKG can present as mechanical consequences between muscle spasticity, weakness, and their interactions with ground reactions during walking. Various underlying mechanisms are presented through sample cases in this article. They include ankle plantar flexor spasticity, knee extensor spasticity, knee flexor and extensor coactivation, and …

Should Canada’S Expansion Of Its Medical Assistance In Dying Program Concern Americans?, Tova Wolkenstein

Cardozo International & Comparative Law Review (CICLR) Blog

After suffering from severe chronic back pain and fearing losing his home, 54-year-old Canadian Amir Farsoud applied to Canada’s Medical Assistance in Dying program (MAID) to alleviate the stresses of his life. Farsoud is just one instance of an individual choosing to die with a physician’s help under the new criteria of MAID. As Canada is America’s “neighbor to the North,” the expansion of physician-assisted suicide there might be a canary in the coal mine as to what will happen in the United States, unless there is an active pushback to stop it.

This post was originally published on the …

Lessons From The Gulf: Female Indigenous Emirati Students’ Persistence And Success At University, Beverley Mcclusky, Bill Allen

Research outputs 2022 to 2026

Students’ persistence and success remain significant issues for universities worldwide, but Tinto (2017a; 2017b) argued that universities need to listen to perspectives of students themselves in identifying what causes them to persist and succeed. This article reports on such perspectives of Indigenous Emirati, Muslim women at one public university in the United Arab Emirates (UAE). Data collection from original doctoral research involved an initial, customised survey completed by 22 Emirati women with subsequent interviews conducted with a further 21 female students. Data for the purpose of this article were analysed using thematic analysis. Findings are presented within Tinto’s framework: goals; …

Poor Seizure Control Among Children Attending A Tertiary Hospital In South Western Uganda – A Retrospective Study, Martha Sajatovic

Faculty Scholarship

Background: Seizure control among children with epilepsy (CWE) receiving anti-seizure medications (ASMs) remains a challenge in low-resource settings. Uncontrolled seizures are significantly associated with increased morbidity and mortality among CWE. This negatively impacts their quality of life and increases stigma. Aim: This study determined seizure control status and described the factors associated among CWE receiving ASMs at Mbarara Regional Referral Hospital (MRRH). Methods: In a retrospective chart review study, socio-demographic and clinical data were obtained from 112 medical records. CWE receiving ASMs for at least six months and regularly attending the clinic were included in the study. Physical or telephone …

Labeled In Your Youth: The Effects Of A Youth Disability Diagnosis In The Workplace, Landon M. Mcfarland, Joanne T. Cao, Edward Sayre

AMTP Proceedings 2023

In recent years, corporate social responsibility policies and an international focus on workplace inclusion have led to an increase in workers’ quality of life and an attempt to end workplace discrimination. Past discrimination research has found many barriers to entry for people with disabilities, a group subject to discrimination based on their perceived competence from the perceptions of employers, co-employees, and customers. Along with negative perceptions, studies find people with disabilities to be subject to wage discrimination. This exploratory study uses the National Longitudinal Study of Youth of 1997 from the U.S. Bureau of Labor Statistics to understand how much …

Variable Shift Lengths Negatively Affect Emergency Medicine Resident Wellness, Marcus Fazzari, Joseph Longobardi, Joseph Mccarthy, Matthew Hysell, Sidney Hann

Journal of Wellness

Introduction: Burnout is very common in emergency medicine and there has been extensive research evaluating factors that contribute to burnout. We sought to examine the contributions of post-graduate year (PGY), shifts worked per month, patients seen per shift, and length of shifts to emergency medicine resident burnout.

Methods: All emergency medicine residents were surveyed with regards to their PGY, shifts worked per month, patients seen per shift, and length of shifts. They were administered the Stanford Wellness Survey and asked to globally rate their degree of burnout. We then modeled whether consideration of the surveyed factors increased the …

Anatomy Lab, Brian R. Smith

Journal of Wellness

No abstract provided.

Modeling And Computation For Unsteady Blood Flow And Solute Concentration In A Constricted Porous Artery, Daniel N. Riahi, Saulo Orizaga

School of Mathematical & Statistical Sciences Faculty Publications

We investigated a physical system for unsteady blood flow and solute transport in a section of a constricted porous artery. The aim of this study was to determine effects of hematocrit, stenosis, pulse oscillation, diffusion, convection and chemical reaction on the solute transport. The significance of this study was uncovering combined roles played by stenosis height, hematocrit, pulse oscillation period, reactive rate, blood speed, blood pressure force and radial and axial extent of the porous artery on the solute transported by the blood flow in the described porous artery. We used both analytical and computational methods to determine blood flow …

National Co2 Budgets (2015-2020) Inferred From Atmospheric Co2 Observations In Support Of The Global Stocktake, Brendan Byrne, David F. Baker, Sourish Basu, Michael Bertolacci, Kevin W. Bowman, Dustin Carroll, Abhishek Chatterjee, Frédéric Chevallier, Philippe Ciais, Noel Cressie, David Crisp, Sean Crowell, Feng Deng, Zhu Deng, Nicholas M. Deutscher, Manvendra K. Dubey, Sha Feng, Omaira E. García, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

Accurate accounting of emissions and removals of CO₂ is critical for the planning and verification of emission reduction targets in support of the Paris Agreement. Here, we present a pilot dataset of country-specific net carbon exchange (NCE; fossil plus terrestrial ecosystem fluxes) and terrestrial carbon stock changes aimed at informing countries' carbon budgets. These estimates are based on "top-down"NCE outputs from the v10 Orbiting Carbon Observatory (OCO-2) modeling intercomparison project (MIP), wherein an ensemble of inverse modeling groups conducted standardized experiments assimilating OCO-2 column-Averaged dry-Air mole fraction (XCO₂) retrievals (ACOS v10), in situ CO₂ measurements or …

Long-Term Gastrointestinal Outcomes Of Covid-19, Evan Xu, Yan Xie, Ziyad Al-Aly

2020-Current year OA Pubs

A comprehensive evaluation of the risks and 1-year burdens of gastrointestinal disorders in the post-acute phase of COVID-19 is needed but is not yet available. Here we use the US Department of Veterans Affairs national health care databases to build a cohort of 154,068 people with COVID-19, 5,638,795 contemporary controls, and 5,859,621 historical controls to estimate the risks and 1-year burdens of a set of pre-specified incident gastrointestinal outcomes. We show that beyond the first 30 days of infection, people with COVID-19 exhibited increased risks and 1-year burdens of incident gastrointestinal disorders spanning several disease categories including motility disorders, acid …

A Comprehensive And Integrative Approach To Mecp2 Disease Transcriptomics, Alexander J Trostle, Lucian Li, Seon-Young Kim, Jiasheng Wang, Rami Al-Ouran, Hari Krishna Yalamanchili, Zhandong Liu, Ying-Wooi Wan

Faculty, Staff and Students Publications

Mutations in MeCP2 result in a crippling neurological disease, but we lack a lucid picture of MeCP2's molecular role. Individual transcriptomic studies yield inconsistent differentially expressed genes. To overcome these issues, we demonstrate a methodology to analyze all modern public data. We obtained relevant raw public transcriptomic data from GEO and ENA, then homogeneously processed it (QC, alignment to reference, differential expression analysis). We present a web portal to interactively access the mouse data, and we discovered a commonly perturbed core set of genes that transcends the limitations of any individual study. We then found functionally distinct, consistently up- and …

The Implementation Playbook: Study Protocol For The Development And Feasibility Evaluation Of A Digital Tool For Effective Implementation Of Evidence-Based Innovations, Melanie Barwick, Jacquie Brown, Kadia Petricca, Bonnie Stevens, Byron J Powell, Alexia Jaouich, Jill Shakespeare, Emily Seto

2020-Current year OA Pubs

BACKGROUND: Evidence-based innovations can improve health outcomes, but only if successfully implemented. Implementation can be complex, highly susceptible to failure, costly and resource intensive. Internationally, there is an urgent need to improve the implementation of effective innovations. Successful implementation is best guided by implementation science, but organizations lack implementation know-how and have difficulty applying it. Implementation support is typically shared in static, non-interactive, overly academic guides and is rarely evaluated. In-person implementation facilitation is often soft-funded, costly, and scarce. This study seeks to improve effective implementation by (1) developing a first-in-kind digital tool to guide pragmatic, empirically based and self-directed …

Social Determinants, Cardiovascular Disease, And Health Care Cost: A Nationwide Study In The United States Using Machine Learning, Feinuo Sun, Jie Yao, Shichao Du, Feng Qian, Allison A Appleton, Cui Tao, Hua Xu, Lei Liu, Qi Dai, Brian T Joyce, Drew R Nannini, Lifang Hou, Kai Zhang

2020-Current year OA Pubs

Background Existing studies on cardiovascular diseases (CVDs) often focus on individual-level behavioral risk factors, but research examining social determinants is limited. This study applies a novel machine learning approach to identify the key predictors of county-level care costs and prevalence of CVDs (including atrial fibrillation, acute myocardial infarction, congestive heart failure, and ischemic heart disease). Methods and Results We applied the extreme gradient boosting machine learning approach to a total of 3137 counties. Data are from the

Molnupiravir And Risk Of Hospital Admission Or Death In Adults With Covid-19: Emulation Of A Randomized Target Trial Using Electronic Health Records, Yan Xie, Benjamin Bowe, Ziyad Al-Aly

2020-Current year OA Pubs

OBJECTIVE: To emulate a randomized target trial to estimate the association between the antiviral drug molnupiravir and hospital admission or death in adults with SARS-CoV-2 infection in the community during the omicron predominant era who were at high risk of progression to severe covid-19.

DESIGN: Emulation of a randomized target trial using electronic health records.

SETTING: US Department of Veterans Affairs.

PARTICIPANTS: 85 998 adults with SARS-CoV-2 infection between 5 January and 30 September 2022 and at least one risk factor for progression to severe covid-19: 7818 participants were eligible for and treated with molnupiravir and 78 180 received no …

Examining Telemental Health In Mississippi: Brief Report, Mario Sobrino, Monica L. Coleman, Janita Springfield, Sheerah Neal, Amanda Winburn

Journal of Counseling Research and Practice

The term telemental health has become a staple of the modern counselor’s lexicon since the start of the COVID-19 pandemic and has led to a surge of new research and practical information for counselors to engage in effective, socially distanced mental health services. Telemental health (TMH) is identified as the use of telecommunication, videoconferencing, and internet-based technologies to provide mental health services (Holland et al., 2018). Although TMH is regarded as an efficient treatment modality for a myriad of mental health issues, the cardinal purpose of its origination was to reduce or eliminate geographic barriers to receiving mental health treatment …

Emotional Abuse: Strategies For Identifying And Reporting, Jill Bryant

Journal of Counseling Research and Practice

Abstract

This article discusses various definitions of emotional abuse, statute difficulties that do little to support an effective report, clinical identifiers and possible long-term outcomes of emotional abuse in children and adolescents. The article closes with suggestions for advocacy efforts to improve the current challenges to better serve youth and adolescents who have been affected by this type of child maltreatment. Readers will find suggested methods for better exploring the topic of emotional abuse in sessions with child and teen clients and proposed approaches to support a stronger report when living in a state with weak or ambiguous statutes.