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Genetic Susceptibility To Diabetic Kidney Disease Is Linked To Promoter Variants Of Xor, Qin Wang, Haiying Qi, Yiming Wu, Liping Yu, Rihab Bouchareb, Shuyu Li, Emelie Lassén, Gabriella Casalena, Krisztian Stadler, Kerstin Ebefors, Zhengzi Yi, Shaolin Shi, Fadi Salem, Ronald Gordon, Lu Lu, Robert W. Williams, Jeremy Duffield, Weijia Zhang, Yuval Itan, Erwin Böttinger, Ilse Daehn Apr 2023

Genetic Susceptibility To Diabetic Kidney Disease Is Linked To Promoter Variants Of Xor, Qin Wang, Haiying Qi, Yiming Wu, Liping Yu, Rihab Bouchareb, Shuyu Li, Emelie Lassén, Gabriella Casalena, Krisztian Stadler, Kerstin Ebefors, Zhengzi Yi, Shaolin Shi, Fadi Salem, Ronald Gordon, Lu Lu, Robert W. Williams, Jeremy Duffield, Weijia Zhang, Yuval Itan, Erwin Böttinger, Ilse Daehn

Division of Basic Science Faculty Publications

The lifetime risk of kidney disease in people with diabetes is 10–30%, implicating genetic predisposition in the cause of diabetic kidney disease (DKD). Here we identify an expression quantitative trait loci (QTLs) in the cis-acting regulatory region of the xanthine dehydrogenase, or xanthine oxidoreductase (Xor), a binding site for C/EBPβ, to be associated with diabetes-induced podocyte loss in DKD in male mice. We examine mouse inbred strains that are susceptible (DBA/2J) and resistant (C57BL/6J) to DKD, as well as a panel of recombinant inbred BXD mice, to map QTLs. We also uncover promoter XOR orthologue variants in humans associated with …


Pharmacological Inhibition Of Cftr Attenuates Nonalcoholic Steatohepatitis (Nash) Progression In Mice, Sangam Rajak, Archana Tewari, Sana Raza, Pratima Gupta, Bandana Chakravarti, Baby Anjum, Madhulika Tripathi, Brijesh K. Singh, Paul M. Yen, Amit Goel, Sujoy Ghosh, Rohit A. Sinha Apr 2023

Pharmacological Inhibition Of Cftr Attenuates Nonalcoholic Steatohepatitis (Nash) Progression In Mice, Sangam Rajak, Archana Tewari, Sana Raza, Pratima Gupta, Bandana Chakravarti, Baby Anjum, Madhulika Tripathi, Brijesh K. Singh, Paul M. Yen, Amit Goel, Sujoy Ghosh, Rohit A. Sinha

Division of Basic Science Faculty Publications

Nonalcoholic steatohepatitis (NASH) is considered a pivotal stage in nonalcoholic fatty liver disease (NAFLD) progression and increases the risk of end-stage liver diseases such as fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The etiology of NASH is multifactorial and identifying reliable molecular players has proven difficult. Presently, there are no approved drugs for NASH treatment, which has become a leading cause of liver transplants worldwide. Here, using public human transcriptomic NAFLD dataset, we uncover Cystic fibrosis transmembrane conductance receptor (CFTR) as a differentially expressed gene in the livers of human NASH patients. Similarly, murine Cftr expression was also found to be …


Environment-Tolerant Ionic Hydrogel–Elastomer Hybrids With Robust Interfaces, High Transparence, And Biocompatibility For A Mechanical–Thermal Multimode Sensor, Ya Lu, Yiying Yue, Qinqin Ding, Changtong Mei, Xinwu Xu, Shaohua Jiang, Shuijian He, Qinglin Wu, Huining Xiao, Jingquan Han Apr 2023

Environment-Tolerant Ionic Hydrogel–Elastomer Hybrids With Robust Interfaces, High Transparence, And Biocompatibility For A Mechanical–Thermal Multimode Sensor, Ya Lu, Yiying Yue, Qinqin Ding, Changtong Mei, Xinwu Xu, Shaohua Jiang, Shuijian He, Qinglin Wu, Huining Xiao, Jingquan Han

Faculty Publications

The human skin, an important sensory organ, responds sensitively to external stimuli under various harsh conditions. However, the simultaneous achievement of mechanical/thermal sensitivity and extreme environmental tolerance remains an enormous challenge for skin-like hydrogel-based sensors. In this study, a novel skin-inspired hydrogel–elastomer hybrid with a sandwich structure and strong interfacial bonding for mechanical–thermal multimode sensing applications is developed. An inner-layered ionic hydrogel with a semi-interpenetrating network is prepared using sodium carboxymethyl cellulose (CMC) as a nanofiller, lithium chloride (LiCl) as an ionic transport conductor, and polyacrylamide (PAM) as a polymer matrix. The outer-layered polydimethylsiloxane (PDMS) elastomers fully encapsulating the hydrogel …


Metabolic Adaptations And Substrate Oxidation Are Unaffected By Exogenous Testosterone Administration During Energy Deficit In Men, Lee E.E.M. Margolis, Kara L. Marlatt, Claire E. Berryman, Emily E. Howard, Nancy E. Murphy, Christopher T. Carrigan, Melissa N. Harris, Robbie A. Beyl, Eric Ravussin, Stefan M. Pasiakos, Jennifer C. Rood Apr 2023

Metabolic Adaptations And Substrate Oxidation Are Unaffected By Exogenous Testosterone Administration During Energy Deficit In Men, Lee E.E.M. Margolis, Kara L. Marlatt, Claire E. Berryman, Emily E. Howard, Nancy E. Murphy, Christopher T. Carrigan, Melissa N. Harris, Robbie A. Beyl, Eric Ravussin, Stefan M. Pasiakos, Jennifer C. Rood

Clinical Research Faculty Publications

Introduction/Purpose The effects of testosterone on energy and substrate metabolism during energy deficit are unknown. The objective of this study was to determine the effects of weekly testosterone enanthate (TEST; 200 mg·wk-1) injections on energy expenditure, energy substrate oxidation, and related gene expression during 28 d of energy deficit compared with placebo (PLA). Methods After a 14-d energy balance phase, healthy men were randomly assigned to TEST (n = 24) or PLA (n = 26) for a 28-d controlled diet- and exercise-induced energy deficit (55% below total energy needs by reducing energy intake and increasing physical activity). Whole-room indirect calorimetry …


Examining The Acute Glycemic Effects Of Different Types Of Structured Exercise Sessions In Type 1 Diabetes In A Real-World Setting: The Type 1 Diabetes And Exercise Initiative (T1dexi), Michael C. Riddell, Zoey Li, Robin L. Gal, Peter Calhoun, Peter G. Jacobs, Mark A. Clements, Corby K. Martin, Francis J. Doyle, Susana R. Patton, Jessica R. Castle, Melanie B. Gillingham, Roy W. Beck, Michael R. Rickels Apr 2023

Examining The Acute Glycemic Effects Of Different Types Of Structured Exercise Sessions In Type 1 Diabetes In A Real-World Setting: The Type 1 Diabetes And Exercise Initiative (T1dexi), Michael C. Riddell, Zoey Li, Robin L. Gal, Peter Calhoun, Peter G. Jacobs, Mark A. Clements, Corby K. Martin, Francis J. Doyle, Susana R. Patton, Jessica R. Castle, Melanie B. Gillingham, Roy W. Beck, Michael R. Rickels

Clinical Research Faculty Publications

OBJECTIVE Maintenance of glycemic control during and after exercise remains a major chal-lenge for individuals with type 1 diabetes. Glycemic responses to exercise may differ by exercise type (aerobic, interval, or resistance), and the effect of activity type on glycemic control after exercise remains unclear. RESEARCH DESIGN AND METHODS The Type 1 Diabetes Exercise Initiative (T1DEXI) was a real-world study of at-home exercise. Adult participants were randomly assigned to complete six structured aerobic, interval, or resistance exercise sessions over 4 weeks. Participants self-reported study and nonstudy exercise, food intake, and insulin dosing (multi-ple daily injection [MDI] users) using a custom …


Increasing Diversity, Equity, And Inclusion In The Fields Of Nutrition And Obesity: A Roadmap To Equity In Academia, Samantha L. Martin, Michelle I. Cardel, Tiffany L. Carson, James O. Hill, Takara Stanley, Steven Grinspoon, Felicia Steger, Loneke T. Blackman Carr, Maxine Ashby-Thompson, Delisha Stewart, Jamy Ard, Raziel Rojas-Rodriguez, Mabel Toribio, Gabrielle Page-Wilson, Ursula White, Glenn Rowe, Marine Saint-Cyr, Rita Brookheart, Lauren Adele Fowler, Gwen Twillman, Felicia Price, April Stull, Sonia Vega-Lopez, Tony Comuzzie, Catherine M. Kotz, Francoise Knox Kazimierczuk, Monica L. Baskin, Robert Newton, Andrew Greenberg, Camile E. Powe, Dympna Gallagher, David H. Burk, Elissa S. Epel, Paul S. Maclean Apr 2023

Increasing Diversity, Equity, And Inclusion In The Fields Of Nutrition And Obesity: A Roadmap To Equity In Academia, Samantha L. Martin, Michelle I. Cardel, Tiffany L. Carson, James O. Hill, Takara Stanley, Steven Grinspoon, Felicia Steger, Loneke T. Blackman Carr, Maxine Ashby-Thompson, Delisha Stewart, Jamy Ard, Raziel Rojas-Rodriguez, Mabel Toribio, Gabrielle Page-Wilson, Ursula White, Glenn Rowe, Marine Saint-Cyr, Rita Brookheart, Lauren Adele Fowler, Gwen Twillman, Felicia Price, April Stull, Sonia Vega-Lopez, Tony Comuzzie, Catherine M. Kotz, Francoise Knox Kazimierczuk, Monica L. Baskin, Robert Newton, Andrew Greenberg, Camile E. Powe, Dympna Gallagher, David H. Burk, Elissa S. Epel, Paul S. Maclean

Clinical Research Faculty Publications

Research shows that a diverse faculty improves academic, clinical, and research outcomes in higher education. Despite that, persons in minority groups, usually categorized by race or ethnicity, are underrepresented in academia (URiA). The Nutrition Obesity Research Centers (NORCs), supported by the NIDDK, hosted workshops on five separate days in September and October 2020. NORCs convened these workshops to identify barriers and facilitators for diversity, equity, and inclusion (DEI) and provide specific recommendations to improve DEI within obesity and nutrition for individuals from URiA groups. Recognized experts on DEI presented each day, after which the NORCs conducted breakout sessions with key …


Monitoring Body Composition Change For Intervention Studies With Advancing 3d Optical Imaging Technology In Comparison To Dual-Energy X-Ray Absorptiometry, Michael C. Wong, Jonathan P. Bennett, Lambert T. Leong, Isaac Y. Tian, Yong E. Liu, Nisa N. Kelly, Cassidy Mccarthy, Julia M.W. Wong, Cara B. Ebbeling, David S. Ludwig, Brian A. Irving, Matthew C. Scott, James Stampley, Brett Davis, Neil Johannsen, Rachel Matthews, Cullen Vincellette, Andrea K. Garber, Gertraud Maskarinec, Ethan Weiss, Jennifer Rood, Alyssa N. Varanoske, Stefan M. Pasiakos, Steven B. Heymsfield, John A. Shepherd Apr 2023

Monitoring Body Composition Change For Intervention Studies With Advancing 3d Optical Imaging Technology In Comparison To Dual-Energy X-Ray Absorptiometry, Michael C. Wong, Jonathan P. Bennett, Lambert T. Leong, Isaac Y. Tian, Yong E. Liu, Nisa N. Kelly, Cassidy Mccarthy, Julia M.W. Wong, Cara B. Ebbeling, David S. Ludwig, Brian A. Irving, Matthew C. Scott, James Stampley, Brett Davis, Neil Johannsen, Rachel Matthews, Cullen Vincellette, Andrea K. Garber, Gertraud Maskarinec, Ethan Weiss, Jennifer Rood, Alyssa N. Varanoske, Stefan M. Pasiakos, Steven B. Heymsfield, John A. Shepherd

Clinical Research Faculty Publications

Background: Recent 3-dimensional optical (3DO) imaging advancements have provided more accessible, affordable, and self-operating opportunities for assessing body composition. 3DO is accurate and precise in clinical measures made by DXA. However, the sensitivity for monitoring body composition change over time with 3DO body shape imaging is unknown. Objectives: This study aimed to evaluate the ability of 3DO in monitoring body composition changes across multiple intervention studies. Methods: A retrospective analysis was performed using intervention studies on healthy adults that were complimentary to the cross-sectional study, Shape Up! Adults. Each participant received a DXA (Hologic Discovery/A system) and 3DO (Fit3D ProScanner) …


Safety And Tolerability Of Whole Soybean Products: A Dose-Escalating Clinical Trial In Older Adults With Obesity, Candida J. Rebello, Stephen Boué, Ronald J. Levy, Renée Puyau, Robbie A. Beyl, Frank L. Greenway, Mark L. Heiman, Jeffrey N. Keller, Charles F. Reynolds, John P. Kirwan Apr 2023

Safety And Tolerability Of Whole Soybean Products: A Dose-Escalating Clinical Trial In Older Adults With Obesity, Candida J. Rebello, Stephen Boué, Ronald J. Levy, Renée Puyau, Robbie A. Beyl, Frank L. Greenway, Mark L. Heiman, Jeffrey N. Keller, Charles F. Reynolds, John P. Kirwan

Division of Basic Science Faculty Publications

Soybean products have nutrients, dietary fiber, and phytoalexins beneficial for cardiovascular and overall health. Despite their high consumption in Asian populations, their safety in Western diets is debated. We conducted a dose-escalating clinical trial of the safety and tolerability of soybean products in eight older adults (70–85 years) with obesity. Whole green soybean pods grown under controlled conditions were processed to flour (WGS) at the United States Department of Agriculture using common cooking techniques such as slicing and heat treatment. WGS incorporated into food products was consumed at 10 g, 20 g, and 30 g/day for one week at each …


Exercise In The Prevention And Treatment Of Type 2 Diabetes, John P. Kirwan, Elizabeth C. Heintz, Candida J. Rebello, Christopher L. Axelrod Apr 2023

Exercise In The Prevention And Treatment Of Type 2 Diabetes, John P. Kirwan, Elizabeth C. Heintz, Candida J. Rebello, Christopher L. Axelrod

Division of Basic Science Faculty Publications

Type 2 diabetes is a systemic, multifactorial disease that is a leading cause of morbidity and mortality globally. Despite a rise in the number of available medications and treatments available for management, exercise remains a first-line prevention and intervention strategy due to established safety, efficacy, and tolerability in the general population. Herein we review the pre-disposing risk factors for, prevention, pathophysiology, and treatment of type 2 diabetes. We emphasize key cellular and molecular adaptive processes that provide insight into our evolving understanding of how, when, and what types of exercise may improve glycemic control.


Is The Gut Microbiome Implicated In The Excess Risk Of Hypertension Associated With Obstructive Sleep Apnea? A Contemporary Review, Sanah S. Munir, Fatima H. Sert Kuniyoshi, Prachi Singh, Naima Covassin Apr 2023

Is The Gut Microbiome Implicated In The Excess Risk Of Hypertension Associated With Obstructive Sleep Apnea? A Contemporary Review, Sanah S. Munir, Fatima H. Sert Kuniyoshi, Prachi Singh, Naima Covassin

Clinical Research Faculty Publications

Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder and an established risk factor for cardiovascular diseases, including hypertension. The pathogenesis of elevated blood pressure (BP) in OSA is multifactorial, including sympathetic overdrive, vascular aberrations, oxidative stress, inflammation, and metabolic dysregulation. Among the mechanisms potentially involved in OSA-induced hypertension, the role of the gut microbiome is gaining increasing attention. Perturbations in the diversity, composition, and function of the gut microbiota have been causally linked to numerous disorders, and robust evidence has identified gut dysbiosis as a determinant of BP elevation in various populations. In this brief review, we summarize …


A Review Of Methods Of Assessing Preference For Social Stimuli, Samuel L. Morris, Madison L. Gallagher, Alva E. Allen Apr 2023

A Review Of Methods Of Assessing Preference For Social Stimuli, Samuel L. Morris, Madison L. Gallagher, Alva E. Allen

Faculty Publications

Research on preference and reinforcer assessments has historically focused on the evaluation of edible and leisure reinforcers, but the identification and use of individualized social reinforcers may be beneficial for several reasons. Recently, many studies have evaluated methods of assessing preference for social stimuli. The procedures and outcomes across these studies have varied greatly, and the current state of evidence for methods of assessing preference for social stimuli remains unclear. Thus, we conducted a review to synthesize all previous research in this area, evaluate the evidence for the utility of this general methodology, and identify factors that may influence its …


The Impact Of Covid-19, Mental Health Distress, And School-Based Sociocultural Protective Factors Among Elementary-Aged Children And Their Caregivers, Aijah K.B. Goodwin, Anthony J. Roberson, Ar’Reon Watson, Grace L. Chen, Anna C.J. Long Apr 2023

The Impact Of Covid-19, Mental Health Distress, And School-Based Sociocultural Protective Factors Among Elementary-Aged Children And Their Caregivers, Aijah K.B. Goodwin, Anthony J. Roberson, Ar’Reon Watson, Grace L. Chen, Anna C.J. Long

Faculty Publications

Given the individual and systemic stress endured by children and families during the COVID-19 pandemic, research examining culturally responsive school experiences and supports to enhance resilience is critical. This study examined the relationship between caregivers’ perceptions of COVID-19 impact, mental health distress among children and caregivers, and school-based sociocultural protective factors, including culturally responsive practices in schools and the relationships between teachers and caregivers, concurrently and longitudinally. Data were collected from caregivers of elementary-aged children at two-time points from March to April 2020 (N = 174) and one year later in 2021 (N = 114). Regression analyses revealed that COVID-19 …


Environmental Attitudes And Fertility Desires Among Us Adolescents From 2005–2019, Heather M. Rackin, Alison Gemmill, Caroline Sten Hartnett Apr 2023

Environmental Attitudes And Fertility Desires Among Us Adolescents From 2005–2019, Heather M. Rackin, Alison Gemmill, Caroline Sten Hartnett

Faculty Publications

Objective: This brief report examines links between environmental attitudes and fertility desires over time in the United States. Background: To understand fertility decision making, it is important to identify factors that influence fertility desires. Concerns about environmental problems may be associated with lower desired fertility, especially in recent cohorts transitioning to adulthood. Youth may feel that having one less child can reduce their “carbon footprint” or may be unwilling to bring children into an uncertain and difficult future due to climate change. Method: Data are from 12th graders in the Monitoring the Future study (2005–2019; N = 34,104). Regression is …


Total Daily Energy Expenditure Has Declined Over The Past Three Decades Due To Declining Basal Expenditure, Not Reduced Activity Expenditure, John R. Speakman, Jasper M.A. De Jong, Srishti Sinha, Klaas R. Westerterp, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Liam J. Anderson, Lenore Arab, Kweku Bedu-Addo, Stephane Blanc, Alberto G. Bonomi, Pascal Bovet, Soren Brage, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Jamie A. Cooper, Richard Cooper, Sai Krupa Das, Peter S.W. Davies, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Melanie Gillingham, Santu Ghosh, Annelies H. Goris, Michael Gurven, Lewis G. Halsey, Catherine Hambly, Hinke H. Haisma Apr 2023

Total Daily Energy Expenditure Has Declined Over The Past Three Decades Due To Declining Basal Expenditure, Not Reduced Activity Expenditure, John R. Speakman, Jasper M.A. De Jong, Srishti Sinha, Klaas R. Westerterp, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Liam J. Anderson, Lenore Arab, Kweku Bedu-Addo, Stephane Blanc, Alberto G. Bonomi, Pascal Bovet, Soren Brage, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Jamie A. Cooper, Richard Cooper, Sai Krupa Das, Peter S.W. Davies, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Melanie Gillingham, Santu Ghosh, Annelies H. Goris, Michael Gurven, Lewis G. Halsey, Catherine Hambly, Hinke H. Haisma

Faculty Publications

Obesity is caused by a prolonged positive energy balance1,2. Whether reduced energy expenditure stemming from reduced activity levels contributes is debated3,4. Here we show that in both sexes, total energy expenditure (TEE) adjusted for body composition and age declined since the late 1980s, while adjusted activity energy expenditure increased over time. We use the International Atomic Energy Agency Doubly Labelled Water database on energy expenditure of adults in the United States and Europe (n = 4,799) to explore patterns in total (TEE: n = 4,799), basal (BEE: n = 1,432) and physical activity energy expenditure (n = 1,432) over time. …


Consumers’ Acceptance, Emotions, And Responsiveness To Informational Cues For Air-Fried Catfish (Ictalurus Punctatus) Skin Chips, Silvia Murillo, Ryan Ardoin, Witoon Prinyawiwatkul Apr 2023

Consumers’ Acceptance, Emotions, And Responsiveness To Informational Cues For Air-Fried Catfish (Ictalurus Punctatus) Skin Chips, Silvia Murillo, Ryan Ardoin, Witoon Prinyawiwatkul

Faculty Publications

Catfish (Ictalurus punctatus) skins, as filleting byproduct, were developed into a crispy snack food via air-frying. Consumers rated catfish skin chips (CSC) across sensory modalities (9-point hedonic scales, a just-about-right scale, and “yes/no” for purchase intent, PI) for Plain-, Lemon & Pepper-, and Barbecue-flavored samples during two consumer studies (N = 115 each). Paprika- flavored CSC were excluded from Study 2 due to inferior acceptance and emotional ratings. CSC-elicited emotions were evaluated using a 25-term lexicon with CATA (Check-All-That-Apply) scaling (Study 1) and refined with an abbreviated lexicon containing food-evoked sensation-seeking emotions (5-point intensity scale). The two consumer studies differed …


Evaluation Of Alternative Colony Hybridization Methods For Pathogenic Vibrios, Andrew M. Schwartz, Haley A. Marcotte, Crystal N. Johnson Apr 2023

Evaluation Of Alternative Colony Hybridization Methods For Pathogenic Vibrios, Andrew M. Schwartz, Haley A. Marcotte, Crystal N. Johnson

Faculty Publications

Vibrios, such as Vibrio parahaemolyticus, are naturally occurring halophilic bacteria that are a major cause of foodborne illness. Because of their autochthonous nature, managing vibrio levels in marine and estuarine environments is impossible. Instead, it is crucial to reliably enumerate their abundance to minimize human exposure. One method of achieving this is the direct plating/colony hybridization (DP/CH) method, which has been used to efficiently quantify pathogenic vibrios in oysters and other seafood products. Although successful, the method relies on proprietary resources. We examined alternative approaches, assessed the influence of the reagent suppliers’ source on enumeration accuracy, and made experimental adjustments …


Mapping And Identification Of Molecular Markers For The Pc96 Gene Conferring Resistance To Crown Rust In Oat, Sidrat Abdullah, Gordon Tyler, Belayneh Admassu Yimer, Edyta Paczos-Grzęda, Stephen A. Harrison, James G. Menzies, Kathy Esvelt Klos Apr 2023

Mapping And Identification Of Molecular Markers For The Pc96 Gene Conferring Resistance To Crown Rust In Oat, Sidrat Abdullah, Gordon Tyler, Belayneh Admassu Yimer, Edyta Paczos-Grzęda, Stephen A. Harrison, James G. Menzies, Kathy Esvelt Klos

Faculty Publications

Oat crown rust caused by Puccinia coronata f. sp. avenae P. Syd. & Syd (Pca) is a major constraint to oat (Avena sativa L.) production in many parts of the globe. The objectives of this study were to locate Pc96 on the oat consensus map and to develop SNP markers linked to Pc96 for use in marker-assisted selection. SNP loci linked to the crown rust resistance gene Pc96 were identified by linkage analysis and PACE assays were developed for marker-assisted selection in breeding programs. Pc96 is a race-specific crown rust resistance gene originating from cultivated oat that has been deployed …


Attributes Of Culture Bacteria As Influenced By Ingredients That Help Treat Leaky Gut, Ricardo S. Aleman, David Paz, Roberto Cedillos, Miguel Tabora, Douglas W. Olson, Kayanush Aryana Apr 2023

Attributes Of Culture Bacteria As Influenced By Ingredients That Help Treat Leaky Gut, Ricardo S. Aleman, David Paz, Roberto Cedillos, Miguel Tabora, Douglas W. Olson, Kayanush Aryana

Faculty Publications

Consumers are becoming aware of functional ingredients such as medicinal herbs, polyphenols, mushrooms, amino acids, proteins, and probiotics more than ever before. Like yogurt and its probiotics, L-glutamine, quercetin, slippery elm bark, marshmallow root, N-acetyl-D-glucosamine, licorice root, maitake mushrooms, and zinc orotate have demonstrated health benefits through gut microbiota. The impact of these ingredients on yogurt starter culture bacteria characteristics is not well known. The objective of this study was to determine the influence of these ingredients on the probiotic characteristics, tolerance to gastric juices and lysozyme, protease activity, and viability of Streptococcus thermophilus STI-06 and Lactobacillus bulgaricus LB-12. Acid …


Amino Acid Derivatives Of Chlorin-E6—A Review, Maria Da Graça H. Vicente, Kevin M. Smith Apr 2023

Amino Acid Derivatives Of Chlorin-E6—A Review, Maria Da Graça H. Vicente, Kevin M. Smith

Faculty Publications

Details of the structural elucidation of the clinically useful photodynamic therapy sensitizer NPe6 (15) are presented. NPe6, also designated as Laserphyrin, Talaporfin, and LS-11, is a second-generation photosensitizer derived from chlorophyll-a, currently used in Japan for the treatment of human lung, esophageal, and brain cancers. After the initial misidentification of the structure of this chlorin-e6 aspartic acid conjugate as (13), NMR and other synthetic procedures described herein arrived at the correct structure (15), confirmed using single crystal X-ray crystallography. Interesting new features of chlorin-e6 chemistry (including the intramolecular formation of an anhydride (24)) are reported, allowing chemists to regioselectively conjugate …


New Boron Delivery Agents, Annette G. Beck-Sickinger, Daniel P. Becker, Oksana Chepurna, Bhaskar Das, Sebastian Flieger, Evamarie Hey-Hawkins, Narayan Hosmane, Satish S. Jalisatgi, Hiroyuki Nakamura, Rameshwar Patil, Maria Da Graça H. Vicente, Clara Viñas Apr 2023

New Boron Delivery Agents, Annette G. Beck-Sickinger, Daniel P. Becker, Oksana Chepurna, Bhaskar Das, Sebastian Flieger, Evamarie Hey-Hawkins, Narayan Hosmane, Satish S. Jalisatgi, Hiroyuki Nakamura, Rameshwar Patil, Maria Da Graça H. Vicente, Clara Viñas

Faculty Publications

This proceeding article compiles current research on the development of boron delivery drugs for boron neutron capture therapy that was presented and discussed at the National Cancer Institute (NCI) Workshop on Neutron Capture Therapy that took place on April 20-22, 2022. The most used boron sources are icosahedral boron clusters attached to peptides, proteins (such as albumin), porphyrin derivatives, dendrimers, polymers, and nanoparticles, or encapsulated into liposomes. These boron clusters and/or carriers can be labeled with contrast agents allowing for the use of imaging techniques, such as PET, SPECT, and fluorescence, that enable quantification of tumor-localized boron and their use …


The Case Against The Debt Tax, Vijay Raghavan Apr 2023

The Case Against The Debt Tax, Vijay Raghavan

Faculty Scholarship

No abstract provided.


But This Rewards Me! An Examination Of Consumer Status And Social Dominance Orientation In The Donation Of Reward Points, Clancy R. Slay, Katharine Howie Apr 2023

But This Rewards Me! An Examination Of Consumer Status And Social Dominance Orientation In The Donation Of Reward Points, Clancy R. Slay, Katharine Howie

AMTP Proceedings 2023

A newer development in rewards programs allows consumers to donate points rather than personally receive benefits. Research on the topic is virtually absent and represents a significant opportunity for worthy causes to receive new streams of financial support. Reward programs are uniquely characterized by hierarchical or “tiered” consumer status. Social dominance orientation represents the degree to which consumers support status inequities and is highly relevant in a reward context. This individual difference characteristic is studied to gain insight into which consumers are willing to donate earned rewards and why. Implications for understanding consumer decision making and encouraging charitable giving are …


Pharmacy Newsletter : April 2023, Pharmacy Department Apr 2023

Pharmacy Newsletter : April 2023, Pharmacy Department

Department of Pharmacy Archives

  • Changes in Global Initiative for Chronic Obstructive Lung Disease (GOLD) Report
  • TOX-TOK: Sulfonylurea Overdose
  • Difference Between Parenteral Iron Products
  • Drug-Drug Interactions Impacting the Treatment of HIV-TB Co-Infection
  • Conversion Between Different Corticosteroid Preparations
  • Use of Analgesics in Adult Patients with Cirrhosis


Quality & Patient Safety Gazette : Volume 2, Issue 2 - 2023, The Aga Khan University Hospital, Karachi Apr 2023

Quality & Patient Safety Gazette : Volume 2, Issue 2 - 2023, The Aga Khan University Hospital, Karachi

Quality and Patient Safety Archives

• CUSP Teams Meet and Greet
• JCI Standards for Clinical Care Program Certification (CCPC)
• Blast from the Past
• Learn with Fun!
• Stay Tuned with Us…..


Spring 2023, University Of North Dakota Alumni Association Apr 2023

Spring 2023, University Of North Dakota Alumni Association

ALL: UND Alumni Review Master List

Spring 2023 issue of "The University of North Dakota Alumni Magazine." 52 pages

Volume 106, Number 2


How Patents Became Politics, Steven Wilf Apr 2023

How Patents Became Politics, Steven Wilf

Faculty Articles and Papers

Political mobilization in the digital age often coalesces around opposition to the far-reaching protection of intellectual property. Both copyright and patent have materialized as the centerpiece of major political and legal debates that take a variety of forms, including the European pirate parties, NGOs such as the Electronic Frontier Foundation in the United States, and the call for open source software. The commonplace narrative is that self-interested stakeholders over the past century successfully fashioned an ever-expanding intellectual property system, and that resistance to such legal control of knowledge only emerged in our times. By contrast, this article recovers a little-known …


Use Of A Worksite Physical Activity To Improve Subjective Daytime Sleepiness Among Night Shift Healthcare Workers: A Quality Improvement Project, Marthe Sooh Nkongo Apr 2023

Use Of A Worksite Physical Activity To Improve Subjective Daytime Sleepiness Among Night Shift Healthcare Workers: A Quality Improvement Project, Marthe Sooh Nkongo

DNP Projects

Background and Significance: Shift work including work schedules beyond the typical "nine-to-five," causes the disruption of sleep-wake behaviors (Healy et al., 2021). The circadian misalignment is a potential pathway for the development of metabolic diseases, excessive daytime sleepiness, sleep deprivation, and declines in alertness and performance among night shift workers (James et al., 2017; McHugh et al., 2020; Parry et al., 2018). Emerging evidence suggests that physical activity synchronizes the sleep-wake cycles (Healy et al., 2021).

Purpose: This quality improvement project (QI) aimed to improve night-shift nurses ‘subjective daytime sleepiness by incorporating a 4-week worksite walking activity during working hours. …


Implementation Of A Daily Central Line Maintenance Audit Form In An Outpatient Infusion Center: A Quality Improvement Project, Sarah E. Christiana Apr 2023

Implementation Of A Daily Central Line Maintenance Audit Form In An Outpatient Infusion Center: A Quality Improvement Project, Sarah E. Christiana

DNP Projects

Significance and Background: Best evidence supports central venous access device (CVAD) dressing changes occur every 7 days or sooner, if indicated. At a community hospital in New England, patients receive outpatient antimicrobial therapy via CVADs. It is vital that nurses adequately maintain CVAD dressings according to evidence-based protocols to reduce the risk of central line-associated bloodstream infection (CLABSI). CLABSIs, associated with increased morbidity, mortality, and health care costs, are largely preventable through proper CVAD maintenance. At the project site, a review identified that dressing changes were frequently changed beyond the 7-day parameter. Documentation and surveillance processes were identified as opportunities …


Anodal Contralesional Tdcs Enhances Cst Excitability Bilaterally In An Adolescent With Hemiparetic Cerebral Palsy: A Brief Report, Rodrigo G. Delatorre, Ellen N. Sutter, Samuel Nemanich, Linda E. Krach, Gregg Meekins, Timothy Feyma, Bernadette T. Gillick Apr 2023

Anodal Contralesional Tdcs Enhances Cst Excitability Bilaterally In An Adolescent With Hemiparetic Cerebral Palsy: A Brief Report, Rodrigo G. Delatorre, Ellen N. Sutter, Samuel Nemanich, Linda E. Krach, Gregg Meekins, Timothy Feyma, Bernadette T. Gillick

Occupational Therapy Faculty Research and Publications

Hemiparetic cerebral palsy (HCP), weakness on one side of the body typically caused by perinatal stroke, is characterized by lifelong motor impairments related to alterations in the corticospinal tract (CST). CST reorganization could be a useful biomarker to guide applications of neuromodulatory interventions, such as transcranial direct current stimulation (tDCS), to improve effectiveness of rehabilitation therapies. We evaluated an adolescent with HCP and CST reorganization who demonstrated persistent heightened CST excitability in both upper limbs following anodal contralesional tDCS. Results support further investigation of targeted tDCS as an adjuvant therapy to traditional neurorehabilitation for upper limb function.


Yale Medicine Magazine Spring 2023, Issue 170, Yale University. School Of Medicine Apr 2023

Yale Medicine Magazine Spring 2023, Issue 170, Yale University. School Of Medicine

Yale Medicine Magazine - alumni bulletin and magazine

This is the Spring 2023 issue of Yale Medicine Magazine, issue 170. Prepared in cooperation with the alumni and development offices at the School of Medicine. Earlier volumes are called Yale School of Medicine alumni bulletins, dating from v.1 (1953) through v.13 (1965) and Yale Medicine: alumni bulletin of the School of Medicine, v.1 (1965) through v. 52, no.1. (Autumn 2017).