Digital Commons Network^™

Rational Design Of A Self-Assembling High Performance Organic Nanofluorophore For Intraoperative Nir-Ii Image-Guided Tumor Resection Of Oral Cancer, Xianwei Sun, Praveen Kumar Chintakunta, Andrew A Badachhape, Rohan Bhavane, Huan-Jui Lee, David S Yang, Zbigniew Starosolski, Ketan B Ghaghada, Peter G Vekilov, Ananth V Annapragada, Eric A Tanifum

Faculty, Staff and Students Publications

The first line of treatment for most solid tumors is surgical resection of the primary tumor with adequate negative margins. Incomplete tumor resections with positive margins account for over 75% of local recurrences and the development of distant metastases. In cases of oral cavity squamous cell carcinoma (OSCC), the rate of successful tumor removal with adequate margins is just 50–75%. Advanced real‐time imaging methods that improve the detection of tumor margins can help improve success rates,overall safety, and reduce the cost. Fluorescence imaging in the second near‐infrared (NIR‐II) window has the potential to revolutionize the field due to its high …

Aberrant Activation Of Tcl1a Promotes Stem Cell Expansion In Clonal Haematopoiesis, Joshua S Weinstock, Jayakrishnan Gopakumar, Bala Bharathi Burugula, Md Mesbah Uddin, Nikolaus Jahn, Julia A Belk, Hind Bouzid, Bence Daniel, Zhuang Miao, Nghi Ly, Taralynn M Mack, Sofia E Luna, Katherine P Prothro, Shaneice R Mitchell, Cecelia A Laurie, Jai G Broome, Kent D Taylor, Xiuqing Guo, Moritz F Sinner, Aenne S Von Falkenhausen, Stefan Kääb, Alan R Shuldiner, Jeffrey R O'Connell, Joshua P Lewis, Eric Boerwinkle, Kathleen C Barnes, Nathalie Chami, Eimear E Kenny, Ruth J F Loos, Myriam Fornage, Lifang Hou, Donald M Lloyd-Jones, Susan Redline, Brian E Cade, Bruce M Psaty, Joshua C Bis, Jennifer A Brody, Edwin K Silverman, Jeong H Yun, Dandi Qiao, Nicholette D Palmer, Barry I Freedman, Donald W Bowden, Michael H Cho, Dawn L Demeo, Ramachandran S Vasan, Lisa R Yanek, Lewis C Becker, Sharon L R Kardia, Patricia A Peyser, Jiang He, Michiel Rienstra, Pim Van Der Harst, Robert Kaplan, Susan R Heckbert, Nicholas L Smith, Kerri L Wiggins, Donna K Arnett, Marguerite R Irvin, Hemant Tiwari, Michael J Cutler, Stacey Knight, J Brent Muhlestein, Adolfo Correa, Laura M Raffield, Yan Gao, Mariza De Andrade, Jerome I Rotter, Stephen S Rich, Russell P Tracy, Barbara A Konkle, Jill M Johnsen, Marsha M Wheeler, J Gustav Smith, Olle Melander, Peter M Nilsson, Brian S Custer, Ravindranath Duggirala, Joanne E Curran, John Blangero, Stephen Mcgarvey, L Keoki Williams, Shujie Xiao, Mao Yang, C Charles Gu, Yii-Der Ida Chen, Wen-Jane Lee, Gregory M Marcus, John P Kane, Clive R Pullinger, M Benjamin Shoemaker, Dawood Darbar, Dan M Roden, Christine Albert, Charles Kooperberg, Ying Zhou, Joann E Manson, Pinkal Desai, Andrew D Johnson, Rasika A Mathias, Thomas W Blackwell, Goncalo R Abecasis, Albert V Smith, Hyun M Kang, Ansuman T Satpathy, Pradeep Natarajan, Jacob O Kitzman, Eric A Whitsel, Alexander P Reiner, Alexander G Bick, Siddhartha Jaiswal

Faculty, Staff and Student Publications

Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells (HSCs), leading to clonal haematopoiesis1. These lesions are precursors for blood cancers2-6, but the basis of their fitness advantage remains largely unknown, partly owing to a paucity of large cohorts in which the clonal expansion rate has been assessed by longitudinal sampling. Here, to circumvent this limitation, we developed a method to infer the expansion rate from data from a single time point. We applied this method to 5,071 people with clonal haematopoiesis. A genome-wide association study revealed that a common inherited polymorphism in the …

Curiosities Of Standing In Trade Secret Law, Charles T. Graves

Northwestern Journal of Technology and Intellectual Property

Standing under the Uniform Trade Secrets Act – the right to pursue a misappropriation claim – is a vexing question when compared to patent, copyright, and trademark law. Instead of requiring ownership or license rights as a condition to sue, courts often find that mere possession of an asserted trade secret suffices for standing, even when the provenance of the information is murky. In some cases, courts even allow trade secret plaintiffs to claim intellectual property rights in the preferences and desires expressed to them by their customers in lawsuits designed to stop former employees from doing business with those …

Replacing Notorious: Barret, Ginsburg, And Postfeminist Positioning, Calvin R. Coker

Faculty and Staff Scholarship

This essay offers a rhetorical reading of Amy Coney Barrett’s confirmation hearings to make sense of how widespread outrage over replacing the late Ruth Bader Ginsburg with a conservative idealogue was resolved through the invocation of postfeminist motherhood. I argue that GOP Senators and Barrett herself positioned her nomination as the achievement of feminist goals, justified through rhetorics of choice and the idealization of (white) motherhood. These strategies cement Barrett as the logical and defensible successor to both Ginsburg’s seat and her legacy of feminist work. I conclude with the implications of this circulation of postfeminist motherhood, with focus on …

Social Psychological Studies Of Latin American Cultures With Particular Reference To Brazil, Peter B. Smith, Taciano L. Milfont, Nelson Hauck Filho

Online Readings in Psychology and Culture

This paper presents an English language translation of a book chapter that was originally published in Portuguese. It is reproduced here in full, by kind permission of the editors and publishers, in order to make it available to English language speakers. The paper first addresses ways of defining culture and the development of measures of cultural variation. Contrasts between the collectivism that defines East Asian culture and the collectivism of Latin America are then identified. Topics addressed include values, self-construal, life satisfaction, emotion, honour culture, social influence and the phenomenon of jeitinho. Although the text leads toward a consideration …

Anti-Obesity And Hypolipidemic Activity Ofpithecellobium Dulceagainst High-Fat Diet-Induced Obesity In Experimental Animals, Ksheerasagar Jagadeeshwar, Rajasekhar Reddy Alavala, Rupaka Subhakar Raju, Koteswara Rao Gsn, Shireesha Boyapati, Appini Narayana Rao

The Thai Journal of Pharmaceutical Sciences

Pithecellobium dulce (PD) (Leguminosae) is conventionally used for many diseases. The objective of this present study intended to assess the anti-obese and hypolipidemic properties of petroleum ether (PEPD), ethyl acetate (EAPD), and methanolic extract (MAPD) of leaves of aerial parts of PD in high-fat diet (HFD)-induced obesity and hypolipidemic effect in obese animals. The present investigation, PD at the doses of 100 and 200 mg/kg, was given along with HFD for 40 days. Our findings such as lipid profiles, serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, glucose, body weight, food intake, body temperature, atherogenic index, coronary index, weight of …

Effects Of Educational And Financial Interventions On The Quality Of Antibiotics Use In Community Care Clinics In Bangkok: An Interrupted Time-Series Analysis, Dararat Samretwit, Yupadee Sirisinsuk

The Thai Journal of Pharmaceutical Sciences

Background: The National Health Security Office (NHSO) has set up the “Rational Drug Use Clinics (RDU)” network to promote the rational use of drugs in community care clinics in Bangkok. Objectives: The objective of the study was to evaluate the effects of educational and financial interventions of antibiotic (ATBs) use in community care clinics in Bangkok. Materials and Methods: A quasi-experimental study, a time series analysis, was conducted. Aggregate weekly prescribing data were extracted from the NHSO Medical Claims Database from October 2013 to September 2019. The Autoregressive Integrated Moving Average (ARIMA) model was utilized to assess intervention effects on …

Wizards And Woods: The Environmental Ethics Of Tolkien’S Istari, Kenton L. Sena, Philip J. Vogel

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

Tolkien’s wizards are some of the most interesting and impactful characters in The Lord of the Rings, sent to Middle-earth to inspire the free peoples to resist Sauron. Principal among the Istari are Gandalf and Saruman, both of whom feature prominently in the events of The Lord of the Rings. A much more minor role, however, is played by Radagast the Brown, who appears only in passing mentions in The Hobbit and serves almost as a messenger in The Lord of the Rings. These three Istari enable an interesting discussion of environmental relationships, with Radagast and Saruman portrayed as failures …

Delamanid And Bedaquiline – A Review On Analytical Methods Determined With Recent Updates On Pharmacokinetics, Pharmacodynamics, And Drug-Drug Interaction, Kamini Sethy, Konduri Raja Rajeswari, Gopal Krishna Padhy

The Thai Journal of Pharmaceutical Sciences

Delamanid and bedaquiline are recently approved drugs for the treatment of multi-drug resistance tuberculosis (TB). It was found that the concomitant use of both drugs helped in treating patients with high drug-resistant strains. Fixed dose combination of delamanid and bedaquiline can be a possibility to control drug resistance TB. Therefore, the objective of this review was to collect data on different analytical methods used so far for the specific quantitation of delamanid and bedaquiline. Such information would be valuable to the research community to develop a new analytical method for the simultaneous analysis of these drugs. Analytical techniques are existing …

Vitamin E: A Simple Treatment For Complicated Diseases, Adhiraj Dasgupta, Sristi Das, Sandipta Ghosh, Krishnendu Acharya

The Thai Journal of Pharmaceutical Sciences

Vitamin E, which belongs to a class of lipid-soluble vitamins, is considered one of the most essential nutrients for the well-being of humans but can solely be obtained through diet. This Vitamin E group includes all the tocol and tocotrienol derivatives which are reported to exhibit diverse biological activities as evident from a literature survey. However, the current pharmacotherapies mainly target the different oxidation processes of the body that have been linked to numerous disease conditions such as cancer, arthritis, atherosclerosis, aging, and others. On that note, Vitamin E has multiple important roles within the body and recent studies indicate …

Physiologically Based Pharmacokinetic Model Of Valproic Acid Using Pk-Sim, Lubna Gandevia, Sahithi Thotakura, Surulivelrajan Mallayasamy

The Thai Journal of Pharmaceutical Sciences

Background: Valproic acid (VPA) is one of the highly prescribed first-line agents for epilepsy. VPA levels are monitored to maintain at appropriate levels. Physiologically based pharmacokinetic modeling (PBPK) is a useful tool for a mechanistic understanding of pharmacokinetics (PKs) of drugs. Objectives: The objective is to develop a PBPK model for VPA using an open-source software platform like PK-Sim with a potential for dosage regimen optimization in epileptic patients. It was also planned to predict the impact of meropenem on the PKs of VPA. Methodology: Anonymized data of Indian epileptic patients with VPA levels were obtained from a prior study …

Anti-Toxic Principle From Moringa Oleifera But Not Myristica Fragrans Ameliorated Sodium Arsenite-Induced Toxicity On Testes And Sex Hormones Of Rats, Adelaja Akinlolu, Mubarak Ameen, Muheen Biliaminu, Mukadam Abdulhamid, Olaolu Ajiboye, Tobilola Quadri, Rukayat Jaji-Sulaimon, Adeoye Oyewopo, Aramide Aiyedogbon, Badejoko Akanmode, Cephas Agbagba, Sikiru Biliaminu, Raheem Akindele

The Thai Journal of Pharmaceutical Sciences

This study evaluated the repro-protective potentials of MOF6 (isolated from Moringa oleifera leaves) and Trimyristin (TR) (isolated from Myristica fragrans seeds) in sodium arsenite (SA)-induced toxicity in rats. Sixty-five adult male rats were randomly divided into 13 groups (n = 5). Groups 1 and 3 received 9-week administrations of physiological saline and olive oil, respectively. Group 2 received 20 mg/kg bodyweight SA-only for 3 weeks and was untreated for 6 weeks. Groups 4–7 received a 3 week SA dose, followed by 6 weeks post-treatments with 5 mg and 7.5 mg/kg bodyweight MOF6, 15 mg, and 30 mg/kg bodyweight TR, respectively. …

Phytochemical Screening, Antihyperglycemic, Antihyperlipidemic, And Antioxidant Activities Of Parts Of Cleome Rutidosperma: A Comparative Study, Israel Oghenevwodokohwo Okoro, Ifeanyi Famous Ossamulu, Edith Omozefe Okoro

The Thai Journal of Pharmaceutical Sciences

Background/Aim: Cleome rutidosperma is traditionally used as a remedy for several diseases such as diabetes and malarial. The phytochemical screening and influence of hydroethanol extracts of C. rutidosperma parts (leaves and roots) on hyperglycemia, hyperlipidemia, and parameters of oxidative stress in streptozotocin (STZ)-induced diabetes in male albino rats were investigated. Materials and Methods: Qualitative phytochemical assays for the extracts were done by standard procedures. Different doses (75, 150, and 300 mg/kg body weight) of the extracts were administered to STZ-induced diabetic rats. Results: The presence of Alkaloids, Flavonoids, Saponins, Tannins, steroids, Terpenoid, Cardiac glycoside, and Phenol was detected in the …

Development Of Topical Mosquito Repellent Emulgels Containing Zanthoxylum Limonella Essential Oils, Walaisiri Muangsiri, Thi Thi San, Pornpen Werawatganone

The Thai Journal of Pharmaceutical Sciences

Emulgels containing 18% w/w Zanthoxylum limonella Alston essential oils were developed as a mosquito repellent. The physical and chemical stabilities and in vivo efficacy of the product were evaluated. Physical stability was tested at 30°C, 75% RH, and 40°C, 75% RH for 3 months or using six heating–cooling cycles. The chemical stability of d-limonene and vanillin contents was analyzed using a gas chromatograph equipped with a flame ionization detector. In vivo mosquito repellency test was performed using the human-bait technique. The product, which contains 11.4% w/w d-limonene and 5% w/w vanillin, was homogeneous and off-white with sweet and mild citrus …

Potential Effects Of Yahom And Thai Massage On Blood Pressure In Prehypertension Patients, Aumpol Bunpean, Oratai Neamsuvan, Sanan Subhadhirasakul, Thanyaluck Siriyong

The Thai Journal of Pharmaceutical Sciences

Purpose: This research aimed to study Thai traditional therapy’s effect in reducing hypertension in prehypertension patients. Design/Methodology/Approach: A quasi-experimental research was conducted on 83 prehypertension patients. Participants were chosen purposively into four groups with different interventions: Yahom formulation (YH) 1, YH2, Thai massage (TM), and control group (CG) with health-care advices. YH1 and YH2 were administered in doses of 2 capsules (500 mg each) 3 times daily before meals for 4 weeks. The intervention period of TM was 60 min/time of once weekly. For CG, participants were advised on life behavior modifications. The tools used consisted of the experimental data …

Attitude, Knowledge, Acceptance, And Willingness To Pay In Covid-19 Vaccination Among Thai Undergraduate Students, Jongrak Nonthing, Wan-Indris Waedoloh, Prakrit Ninlaphai, Krittaphas Kangwanrattanakul

The Thai Journal of Pharmaceutical Sciences

Background: Given the demand for vaccination coverage to ease the pandemic situation and restore normal life in the university, evidence for examining the level of knowledge, attitudes, acceptance, and willingness to pay (WTP) for Coronavirus disease 2019 (COVID-19) vaccine among undergraduate students is required. Therefore, this study examined the level of those aspects among undergraduate students. Methods: A cross-sectional survey study was carried out among 434 participants between March 1, 2022, and March 31, 2022. An online selfadministered, anonymous questionnaire was used to assess knowledge, attitudes, acceptance, and WTP for the COVID-19 vaccines. Results: Respondents had good knowledge, and about …

Community Participation And Perspectives Of Ambondrolava Mangrove Restoration Project, Nadine Shannon

Independent Study Project (ISP) Collection

Madagascar’s mangrove forests are intertidal ecosystems that provide numerous valuable ecosystem services but are nonetheless under pressure from large amounts of deforestation. On the southwestern coast of Madagascar, the village of Ambondrolava practices community led management of the mangrove and its resources. This research project studied the evolution of the mangrove area using GIS data, and investigated, through interviews, the relationship between the local community of Ambondrolava and the organizations that manage the mangrove ecosystem. From 2000 to 2018, the zone of the mangrove has experienced a net loss in area every year, despite reforestation efforts. Most community members interviewed …

Maternal Healthcare Access And Obstetric Complications: A Cause And Effect Relationship?, Lena Sharara

Independent Study Project (ISP) Collection

Poverty-stricken migrant women, named ‘Kayayei or Kayayo’ because of the nature of their job in the informal sector, have high birth rates and are said to have many barriers affecting their access to maternal health resources. In this study, Kayayei in Madina Market were interviewed and both quantitative and qualitative data were gathered to determine whether a relationship exists between access to maternal health and the obstetric complications and outcomes experienced by Kayayei. A Chi-Squared Test of Independence and a Qualitative Content Analysis were both used to analyze the data. Due to a non-significant p-value, it was found that the …

Psychopathology Or Possession: How Ghanaian Pentecostal And Charismatic Christians Understand Mental Illnesses And How Perceived Understandings Vary Depending On If They Are Current Students Or Not, Jamila L. Taffe

Independent Study Project (ISP) Collection

This research investigates the perceptions held by Ghanaian Chrsitians from Pentecostal/Charismatic churches about mental illnesses. The data collected was done through a qualitative method of acquiring information. Interviews were conducted alongside intensive research of existing scholarship that addressed religion and mental health within Ghanaian culture. A total of 5 in depth interviews were carried out with participants ranging from the ages of 20-35. Three participants were current university students at the University of Ghana while the other two were non-students but held degrees. The objective was to make comparisons between the student and non-student groups about their knowledge about mental …

The State Of Transgender And Kinnar Communities In Delhi: Case Studies Connecting Socioeconomic Factors To Health, Ray Craig

Independent Study Project (ISP) Collection

The paper seeks to draw connections between socioeconomic barriers faced by the transgender (trans) community in Delhi, India and the healthcare that the community receives. It primarily discusses transgender people who are not part of the kinnar population, with as much consideration to the experiences of the kinnar community as possible, given limited access to their circles. Five transgender individuals and two cisgender individuals who have worked with trans communities participated in semi-structured qualitative interviews to understand various factors that affect trans people’s daily lives and their healthcare experiences in Delhi. Interviews were transcribed and coded, finding common themes of …

Biocultural Diversity Of Medicine In Tsum Valley, Ashira Weinreich

Independent Study Project (ISP) Collection

Health is intrinsically connected to biodiversity in the Himalayan mountains of Tsum Valley. Medicinal plants have historically been integral to primary health care in this region. The main objectives of this paper are to explore the role of biocultural diversity on perceptions of health and to demonstrate that medicinal plant knowledge contributes to health sovereignty in times of cultural and environmental change. The nutritional and medicinal significance of plants were examined in the daily lives of villagers. Semi-structured interviews were conducted from April to May 2023. Preliminary results are analyzed ethnographically. Interviews and participant observation will provide a rich understanding …

Ecological Living In Nepali Food Systems: A Synthesis Of Circular Nutrient And Knowledge Flows In The Kathmandu Valley, Kaitlyn Feely

Independent Study Project (ISP) Collection

Researching food-systems in Nepal can feel like drinking from a fire hydrant. Sixty-six percent of the population is directly involved in agriculture and a diverse set of ecocultural understandings influence the practice across the country’s landscapes, ranging from the Himalayas to urban centers to southern plains. In the Kathmandu Valley and peripheral hills where I conducted my research, seemingly any spare land was under cultivation, enabled by fertile ground, optimal climate, and market potential. But despite the prevalence of farming in daily life throughout the country, Nepal’s food system is not domestically self-sufficient. A complex web of imports and exports …

The Headbangers Of The Himalaya: An Investigation Of Nepal’S Rock And Metal Scene, Samuel White

Independent Study Project (ISP) Collection

The goal of this research endeavor was to generate findings which unveil information about the culture, the bands, and the lives of the musicians and fans who make up the Nepali rock and metal scene. The community is rather esoteric and information regarding certain bands and their musicians’ background is limited to broad, outdated articles published online. Thus, most of the information regarding the scene can only be obtained if one truly immerses themselves within it. I was fortunate enough to make friends which granted me a firsthand look into the Nepali rock and metal scene. The general questions which …

Unveiling Anti-Blackness In Moroccan Society: A Historical And Contemporary Analysis, Olivia Talbert

Independent Study Project (ISP) Collection

The purpose of this investigation is to delve into the complex dynamics of how blackness is perceived and negotiated within the intricate social fabric of Moroccan society. Drawing on the theoretical framework of black political thought, this study examines the interrelated systems of race, colonialism, and diaspora to trace the formation of black identity in Morocco, its navigation, and its manifestation in contemporary times. The Moroccan state has recently come under scrutiny for its treatment of Sub-Saharan migrants, who have been subjected to racism both from the police and the Moroccan people. This is even though black Moroccans with indigenous …

Introduction: Access To Healthcare Symposium, Yvonne F. Lindgren

Faculty Works

The four Articles in this Access to Healthcare symposium edition address the different ways that the U.S. healthcare delivery system is failing marginalized communities, including individuals who are disabled, who are birthing, who are women of color or represent another marginalized group, or who live in poverty. The result is a rich conversation that uncovers the complex systems that contribute to unequal access to health care and unjust disparities in health outcomes in the United States.

Telegraph, Telephone And The Internet: The Making Of The Symbiotic Model Of Surveillance States, Dongsheng Zang

Articles

In the early 2000s, shortly before the September 11 attacks, Daniel J. Solove noted that computer databases in the United States were controlled by public as well as private bureaucracies. In that sense, Solove argued, the "Big Brother" metaphor "fails to capture the most important dimension of the database problem." In his 2008 Lockhart lecture, constitutional law scholar Jack M. Balkin argued that the United States has gradually transformed from a welfare and national security state to a National Surveillance State: "a new form of governance that features the collection, collation, and analysis of information about populations both in the …

3rd Place Contest Entry: Using The Scientific Method To Combat The Biological And Sociological Effects Of The Covid-19 Pandemic: An Aspiring Healthcare Professional’S Perspective, Isabelle Dhindsa

Kevin and Tam Ross Undergraduate Research Prize

This is Isabelle Dhindsa's submission for the 2023 Kevin and Tam Ross Undergraduate Research Prize, which won third place. It contains their essay on using library resources, their bibliography, and a sample of their research project on using the scientific method to combat the biological and sociological effects of the COVID-19 pandemic.

Isabelle is a fourth-year student at Chapman University, majoring in Biology. Their faculty mentor is Dr. Carmichael Peters.

Single-Center Experience With Tixagevimab/Cilgavimab Pre-Exposure Prophylaxis Against Sars-Cov-2 Infection In Kidney And Pancreas Transplant Recipients, Milisha Shah Pharmd, Bcps, Bctxp, Hope Kincaid Mph, Cph, Alison Sutter Mph, Christine Du Md, Patty Liu Md, Michael J. Moritz Md

Department of Pharmacy

No abstract provided.

White Coat Color Of A Black Angus Calf Attributed To An Occurrence Of The Delr217 Variant Of Mitf, Jessica Lynn Petersen, Renae L. Sieck, David J. Steffen

Department of Animal Science: Faculty Publications

A white calf, with minimal pigmented markings, was born to two registered Black Angus parents. Given the possibility of an unknown recessive or de novo dominant mutation, whole-genome sequencing was conducted on the trio of individuals. A 3-bp in-frame deletion in MITF was identified; this mutation was unique to the calf but identical to the delR217 variant reported in both humans and murine models of Waardenburg syndrome type 2A and Tietz syndrome. Given the coat color phenotype and identity of the mutation, our data support that this calf represents the first instance of this recurring MITF mutation in cattle.

Transition Ready: Improving Transition Planning For Students With Asd In Rural Georgia Using An Occupational Therapy Based Program, Christen Flowers, Keisa Boykin, Thais Petrocelli

Spring 2023 Virtual OTD Capstone Symposium

PURPOSE To develop an occupational therapy based program to educate school staff and personnel about the transition planning process