Digital Commons Network^™

Data Encoding For Healthcare Data Democratization And Information Leakage Prevention, Anshul Thakur, Tingting Zhu, Vinayak Abrol, Jacob Armstrong, Yujiang Wang, David A Clifton

Faculty, Staff and Student Publications

The lack of data democratization and information leakage from trained models hinder the development and acceptance of robust deep learning-based healthcare solutions. This paper argues that irreversible data encoding can provide an effective solution to achieve data democratization without violating the privacy constraints imposed on healthcare data and clinical models. An ideal encoding framework transforms the data into a new space where it is imperceptible to a manual or computational inspection. However, encoded data should preserve the semantics of the original data such that deep learning models can be trained effectively. This paper hypothesizes the characteristics of the desired encoding …

Collagen Type Xii Is Undetectable In Keratoconus Bowman’S Layer, Mohammed Rigi, Hyeck-Soo Son, Loren Moon, Mario Matthaei, Divya Srikumaran, Albert S Jun, Charles G Eberhart, Uri S Soiberman

Faculty, Staff and Student Publications

PURPOSE: Corneal biomechanical failure is the hallmark of keratoconus (KC); however, the cause of this failure remains elusive. Collagen type XII (

METHODS: TaqMan quantitative PCR was performed on 31 corneal epithelium samples of progressive KC and myopic control eyes. Tissue microarrays were constructed using full-thickness corneas from 61 KC cases during keratoplasty and 18 non-KC autopsy eyes and stained with an antibody specific to COL12A1. Additionally,

RESULTS: COL12A1 expression was reduced at transcript levels in KC epithelium compared to controls (ratio: 0.58, p<0.03). Immunohistochemical studies demonstrated that COL12A1 protein expression in BL was undetectable, with reduced expression in KC epithelium, basement membrane, and stroma.

CONCLUSIONS: The apparent absence of COL12A1 in KC BL, together with the functional importance that

Impact Of Immunopathy And Coagulopathy On Multi-Organ Failure And Mortality In A Lethal Porcine Model Of Controlled And Uncontrolled Hemorrhage, Milomir O Simovic, James Bynum, Bin Liu, Jurandir J Dalle Lucca, Yansong Li

Faculty, Staff and Student Publications

Uncontrolled hemorrhage is a major preventable cause of death in patients with trauma. However, the majority of large animal models of hemorrhage have utilized controlled hemorrhage rather than uncontrolled hemorrhage to investigate the impact of immunopathy and coagulopathy on multi-organ failure (MOF) and mortality. This study evaluates these alterations in a severe porcine controlled and uncontrolled hemorrhagic shock (HS) model. Anesthetized female swine underwent controlled hemorrhage and uncontrolled hemorrhage by partial splenic resection followed with or without lactated Ringer solution (LR) or Voluven® resuscitation. Swine were surveyed 6 h after completion of splenic hemorrhage or until death. Blood chemistry, physiologic …

The Effects Of Covid-19 Mrna Vaccine On Adolescence Gynecological Well-Being, Shih-Chiao Tseng, Dana Cherry, Mansoo Ko, Steven R Fisher, Michael Furtado, Shuo-Hsiu Chang

Faculty, Staff and Student Publications

PURPOSE: Evidence suggests that transcranial direct current stimulation (tDCS) can enhance motor performance and learning of hand tasks in persons with chronic stroke (PCS). However, the effects of tDCS on the locomotor tasks in PCS are unclear. This pilot study aimed to: (1) determine aggregate effects of anodal tDCS combined with step training on improvements of the neural and biomechanical attributes of stepping initiation in a small cohort of persons with chronic stroke (PCS) over a 4-week training program; and (2) assess the feasibility and efficacy of this novel approach for improving voluntary stepping initiation in PCS.

METHODS: A total …

Degree Of Uncertainty In Reporting Imaging Findings For Necrotizing Enterocolitis: A Secondary Analysis From A Pilot Randomized Diagnostic Trial., Alain Cuna, Disa Rathore, Kira Bourret, Erin K. Opfer, Sherwin S. Chan

Manuscripts, Articles, Book Chapters and Other Papers

Diagnosis of necrotizing enterocolitis (NEC) relies heavily on imaging, but uncertainty in the language used in imaging reports can result in ambiguity, miscommunication, and potential diagnostic errors. To determine the degree of uncertainty in reporting imaging findings for NEC, we conducted a secondary analysis of the data from a previously completed pilot diagnostic randomized controlled trial (2019-2020). The study population comprised sixteen preterm infants with suspected NEC randomized to abdominal radiographs (AXRs) or AXR + bowel ultrasound (BUS). The level of uncertainty was determined using a four-point Likert scale. Overall, we reviewed radiology reports of 113 AXR and 24 BUS …

Ay 2023/2024 Fs Meeting Minutes, 2024-02-21, Faculty Senate

Faculty Senate Archives

No abstract provided.

Evaluating Sojump.Com As A Tool For Online Behavioral Research In China, Alessandro Del Ponte, Lianjun Li, Lina Ang, Noah Lim, Wei Jie Seow

Political Science Faculty Articles and Research

SoJump.com (wjx.cn; in short: SoJump) is a survey company that allows researchers to build and deploy inexpensive online surveys in China. Here we evaluate SoJump’s data quality and similarity to the national benchmark. In the first study, we compare SoJump’s performance in China to MTurk’s performance against national benchmarks in the United States and India. In the second study, we compare three Chinese platforms in two-wave panel studies. We conducted the panels on SoJump, Credamo (SoJump’s major competitor), and Cint (national benchmark). We included attention and comprehension checks, economic games, cognitive tasks, and a framing experiment. We find that SoJump’s …

Private Sector Staff’S Lived Experiences With Gamified Onboarding Programs, Willa Thorpe

Walden Dissertations and Doctoral Studies

Although gamification is an emerging area of study, it is still a relatively new concept in workplaces. The purpose of this qualitative study was to explore the lack of existing literature on the topic of an interpretative, phenomenological analysis approach of private sector staff when gamification is utilized in onboarding processes. Data were collected via 12 individual semistructured interviews of full- or part-time employees at a partner organization in the information technology sector in India. Self-determination theory was used as the conceptual framework of this study. The research questions explored the lived experiences of staff with gamified onboarding programs and …

Structural Insights Into Peptidoglycan Glycosidase Etga Binding To The Inner Rod Protein Esci Of The Type Iii Secretion System Via A Designed Esci-Etga Fusion Protein, Jacob Boorman, Focco Van Den Akker

Faculty Scholarship

Bacteria express lytic enzymes such as glycosidases, which have potentially self-destructive peptidoglycan (PG)-degrading activity and, therefore, require careful regulation in bacteria. The PG glycosidase EtgA is regulated by localization to the assembling type III secretion system (T3SS), generating a hole in the PG layer for the T3SS to reach the outer membrane. The EtgA localization was found to be mediated via EtgA interacting with the T3SS inner rod protein EscI. To gain structural insights into the EtgA recognition of EscI, we determined the 2.01 Å resolution structure of an EscI (51–87)-linker-EtgA fusion protein designed based on AlphaFold2 predictions. The structure …

Spectrum, Volume 52, Issue 4, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: The Road to Recovery for Student's Facing Addiction - A "Heart to Heart on College Student Mental Health" - "Destination Senior Week" - A Learning “Playground for Everybody” at the IDEA Lab - Embracing Faith Through Sisterhood - A Guide to SHU Global

Hydroxyl- Terminated Dendrimers With Sulfonimide Linkers As Binders For Metals Of Industrial Significance, Khaleel Abu Sbeih, Mohammad Al Harahsheh

Turkish Journal of Chemistry

First- and second-generation hydroxyl- terminated dendrimers were prepared starting from a 1,3-diaminopropane core and sulfonimide linkers. A first-generation mesitylene-derived dendrimer was also prepared with the same terminals. The dendrimers were then reacted with Fe3+, Al3+, and UO22+ separately in order to apply the dendrimers for binding these metals, which have important industrial applications and pose environmental problems simultaneously. The prepared dendrimers were also shown to bind Fe3+ selectively from mixtures with Al3+.

Palladium (0) Nanoparticles Distributed On Lanthanum (Iii) Oxide As An Effective Catalyst For The Methanolysis Of Hydrazine-Borane To Produce Hydrogen, Adem Rüzgar, Lokman Şener, Yaşar Karataş, Mehmet Gülcan

Turkish Journal of Chemistry

Pd (0) nanoparticles (NPs) distributed on lanthanum (III) oxide were ex situ generated from the reduction of Pd2+ ions using NaBH4 as reducing agent. The Pd/La2O3 displayed good catalytic activity in H2(g) releasing from the hydrazine-borane (HB) methanolysis reaction and it was identified by advanced techniques. Pd/La2O3 was found to be an active catalyst procuring three equiv. H2(g) per mole of HB. The results from TEM images represent the formation of Pd (0) NPs with an average particle size of 1.94 ± 0.1 nm on the surface of La2O3. Moreover, Pd/La2O3 with various Pd loadings were prepared and tested as …

N-(2-Aminobenzoyl)Benzotriazole Mediated Synthesis Of 3- Acyl-2-Alkyl(Aryl)-4-Hydroxyquinolines And 3-Acylamino-4(3h) Quinazolinones, İlbilge Merve Şenol, Sevtem Gökbulut Satioğlu, İlhami Çeli̇k

Turkish Journal of Chemistry

New methods have been developed for the synthesis of the substituted quinolines and quinazolinones derivatives by utilizing N-(2-aminobenzoyl)benzotriazoles under mild reaction conditions. 3-Acyl-2-alkyl(aryl)-4-hydroxyquinolines were obtained in modarete yields by the reaction of N-(2-aminobenzoyl)benzotriazoles and diketones in the presence of tert-BuOK. 3-Acylamino-4(3H) quinazolinones were obtained in good yields via N-(2-aminobenzoyl)benzotriazoles, orthoester and hyrazides in one-pot.

Winonan, Winona State University

The Winonan - 2020s

This issue of the Winonan, the Winona State University student newspaper, was published on February 21, 2024.

Influence Of Convective Heat Transfer Coefficients On Thermal Behaviour Of A Lithium-Ion Cell: A Numerical Study, Uğur Morali

Turkish Journal of Chemistry

In the current study, the impact of C-ratio, convective heat transfer coefficient, and free stream temperature on the maximal cell temperature and temperature uniformity was computationally and statistically examined. Results revealed that the free stream temperature was the main influential factor for the maximal cell temperature for both natural and forced convection conditions while the C-ratio was the most effective parameter for the temperature uniformity for both natural and forced convections. On the other hand, the contribution of the free stream temperature to the maximum battery temperature increased from 63% to 94% when the conditions were changed from natural convection …

Structure-Activity Relationship Of Anticancer Drug Candidate Quinones, Nadire Özenver, Neslihan Sönmez, Merve Yüzbaşıoğlu Baran, Ayşe Uz, Lütfiye Ömür Demi̇rezer

Turkish Journal of Chemistry

Breast cancer is one of the most prevalent cancer types worldwide. Chemotherapy is a substantial approach in the management of breast cancer despite the occurrence of chemotherapy-associated side effects and the development of multidrug resistance in cancer cells. At this point, a variety of quinone derivatives may represent potential as possible anticancer drug candidates due to possessing structural similarity towards clinically used anticancer drugs like doxorubicin. Therefore, we investigated the cytotoxic effects of various quinone derivatives with structural diversity towards a variety of breast cancer cells. We further determined their toxicity in healthy cells to evaluate their drug capability potential. …

Recent Advances And Applications Of Nanostructured Membranes In Water Purification, Didem Aydin, İlkay Hilal Gübbük, Mustafa Ersöz

Turkish Journal of Chemistry

In recent years, water pollution caused by hazardous materials such as metals, drugs, pesticides, and insecticides has become a very serious environmental and health problem that needs to be addressed urgently. The nutritional needs associated with the increasing population also increase the demand for water use and rapidly increase the rate of freshwater consumption. Since most of the water in the universe is in the form of sea water, which cannot be directly used, freshwater resources are limited ,compared to the existing available water. When addressing the purification of all kinds of pollution in environmental research, nanostructured membranes attract attention …

Chromium Speciation In Water Using Magnetic Polyaniline Nanoparticles Coupled With Microsampling Injection-Flame Atomic Absorption Spectroscopy, Osman Çaylak

Turkish Journal of Chemistry

The chromium speciation procedure was optimized using magnetic polyaniline nanoparticles (Fe3O4@PANI NPs) solid-phase extraction coupled with microsampling injection-flame atomic absorption spectrometry (MIS-FAAS). Chromium speciation was successfully achieved by Fe3O4@PANI NPs at pH 8.0. The recoveries obtained for Cr(III) and Cr(VI) were above 95% and under 5%, respectively. Recoveries of over 95% for Cr(III) from 40.0 mL of the sample were obtained using 25 mg Fe3O4@PANI NPs and 500 µL of 0.2% (w/v) thiourea (TU) solution prepared in 2 mol L–1 HCl as eluent. Total chromium as Cr(III) was extracted quantitatively after reducing the Cr(VI) to Cr(III). The linear range, detection …

Progestin-Associated Meningiomatosis With Unusual Schwannoma-Like Morphology, Katherine A Krause, Jared K Woods, Alexandra J Golby, Eudocia Q Lee, Shyam Tanguturi, Zachary Spigelman, Azra H Ligon, Umberto De Girolami, Matthew Torre

Duncan NRI Faculty and Staff Publications

No abstract provided.

Novel Design And Analysis For Rare Disease Drug Development, Shein-Chung Chow, Annpey Pong, Susan S. Chow

Student Publications

For rare disease drug development, the United States (US) Food and Drug Administration (FDA) has indicated that the same standards as those for drug products for common conditions will be applied. To assist the sponsors in rare disease drug development, the FDA has initiated several incentive programs to encourage the sponsors in rare disease drug development. In practice, these incentive programs may not help in achieving the study objectives due to the limited small patient population. To overcome this problem, some out-of-the-box innovative thinking and/or approaches, without jeopardizing the integrity, quality, and scientific validity of rare disease drug development, are …

A Stool Based Qpcr For The Diagnosis Of Tb In Children And People Living With Hiv In Uganda, Eswatini And Mozambique (Stool4tb): A Protocol For A Multicenter Diagnostic Evaluation, Lucia Carratala-Castro, Willy Ssengooba, Alex Kay, Sozinho Acácio, Joanna Ehrlich, Andrew R Dinardo, Nosisa Shiba, Joachim K Nsubuga, Shilzia Munguambe, Belén Saavedra-Cervera, Patricia Manjate, Durbbin Mulengwa, Busizwe Sibandze, Mangaliso Ziyane, George Kasule, Edson Mambuque, Moorine Penninah Sekadde, Eric Wobudeya, Moses L Joloba, Jan Heyckendorf, Christoph Lange, Sabine Hermans, Anna Mandalakas, Alberto L García-Basteiro, Elisa Lopez-Varela, Stool4tb Global Partnership

Faculty, Staff and Students Publications

BACKGROUND: Tuberculosis (TB) is a major cause of mortality worldwide. Children and people living with HIV (PLHIV) have an increased risk of mortality, particularly in the absence of rapid diagnosis. The main challenges of diagnosing TB in these populations are due to the unspecific and paucibacillary disease presentation and the difficulty of obtaining respiratory samples. Thus, novel diagnostic strategies, based on non-respiratory specimens could improve clinical decision making and TB outcomes in high burden TB settings. We propose a multi-country, prospective diagnostic evaluation study with a nested longitudinal cohort evaluation to assess the performance of a new stool-based qPCR, developed …

Detection And Monitoring Of Plant Pathogens And Pests, Walter F. Mahaffee, Lindsey D. Thiessen, Kevin M. King, Robin A. Choudhury

School of Earth, Environmental, & Marine Sciences Faculty Publications

No abstract provided.

Leveraging Artificial Intelligence To Advance Implementation Science: Potential Opportunities And Cautions, Katy E Trinkley, Ruopeng An, Anna M Maw, Russell E Glasgow, Ross C Brownson

2020-Current year OA Pubs

BACKGROUND: The field of implementation science was developed to address the significant time delay between establishing an evidence-based practice and its widespread use. Although implementation science has contributed much toward bridging this gap, the evidence-to-practice chasm remains a challenge. There are some key aspects of implementation science in which advances are needed, including speed and assessing causality and mechanisms. The increasing availability of artificial intelligence applications offers opportunities to help address specific issues faced by the field of implementation science and expand its methods.

MAIN TEXT: This paper discusses the many ways artificial intelligence can address key challenges in applying …

Treatment Strategies For Anti-Vegf Resistance In Neovascular Age-Related Macular Degeneration By Targeting Arteriolar Choroidal Neovascularization, Yingbin Fu, Zhao Zhang, Keith A Webster, Yannis M Paulus

Faculty, Staff and Students Publications

Despite extensive use of intravitreal anti-vascular endothelial growth factor (anti-VEGF) biologics for over a decade, neovascular age-related macular degeneration (nAMD) or choroidal neovascularization (CNV) continues to be a major cause of irreversible vision loss in developed countries. Many nAMD patients demonstrate persistent disease activity or experience declining responses over time despite anti-VEGF treatment. The underlying mechanisms of anti-VEGF resistance are poorly understood, and no effective treatment strategies are available to date. Here we review evidence from animal models and clinical studies that supports the roles of neovascular remodeling and arteriolar CNV formation in anti-VEGF resistance. Cholesterol dysregulation, inflammation, and ensuing …

Pre-Infection Innate Immunity Attenuates Sars-Cov-2 Infection And Viral Load In Ipsc-Derived Alveolar Epithelial Type 2 Cells, Satish Kumar, Jose C. Granados, Miriam Aceves, Juan M. Peralta, Ana C. Leandro, John M. Thomas, Sarah Williams-Blangero, Joanne E. Curran, John Blangero

School of Medicine Publications

A large portion of the heterogeneity in coronavirus disease 2019 (COVID-19) susceptibility and severity of illness (SOI) remains poorly understood. Recent evidence suggests that SARS-CoV-2 infection-associated damage to alveolar epithelial type 2 cells (AT2s) in the distal lung may directly contribute to disease severity and poor prognosis in COVID-19 patients. Our in vitro modeling of SARS-CoV-2 infection in induced pluripotent stem cell (iPSC)-derived AT2s from 10 different individuals showed interindividual variability in infection susceptibility and the postinfection cellular viral load. To understand the underlying mechanism of the AT2′s capacity to regulate SARS-CoV-2 infection and cellular viral load, a genome-wide differential …

Nrf2 Activation In Trp53;P16-Deficient Mice Drives Oral Squamous Cell Carcinoma, Samera H Hamad, Rani S Sellers, Nathan Wamsley, Paul Zolkind, Travis P Schrank, Michael B Major, Bernard E Weissman

2020-Current year OA Pubs

UNLABELLED: Aberrant activation of the NRF2/NFE2L2 transcription factor commonly occurs in head and neck squamous cell carcinomas (HNSCC). Mouse model studies have shown that NRF2 activation alone does not result in cancer. When combined with classic oncogenes and at the right dose, NRF2 activation promotes tumor initiation and progression. Here we deleted the tumor suppressor genes p16INK4A and p53 (referred to as CP mice), which are commonly lost in human HNSCC, in the presence of a constitutively active NRF2E79Q mutant (CPN mice). NRF2E79Q expression in CPN mice resulted in squamous cell hyperplasia or dysplasia with hyperkeratosis in the esophagus, oropharynx, …

Multi-Molecular Hyperspectral Prm-Srs Microscopy, Wenxu Zhang, Yajuan Li, Anthony A Fung, Zhi Li, Hongje Jang, Honghao Zha, Xiaoping Chen, Fangyuan Gao, Jane Y Wu, Huaxin Sheng, Junjie Yao, Dorota Skowronska-Krawczyk, Sanjay Jain, Lingyan Shi

2020-Current year OA Pubs

Lipids play crucial roles in many biological processes. Mapping spatial distributions and examining the metabolic dynamics of different lipid subtypes in cells and tissues are critical to better understanding their roles in aging and diseases. Commonly used imaging methods (such as mass spectrometry-based, fluorescence labeling, conventional optical imaging) can disrupt the native environment of cells/tissues, have limited spatial or spectral resolution, or cannot distinguish different lipid subtypes. Here we present a hyperspectral imaging platform that integrates a Penalized Reference Matching algorithm with Stimulated Raman Scattering (PRM-SRS) microscopy. Using this platform, we visualize and identify high density lipoprotein particles in human …

Effects Of Complete And Partial Loss Of The 24s-Hydroxycholesterol-Generating Enzyme, Hong-Jin Shu, Luke H Ziolkowski, Sofia V Salvatore, Ann M Benz, David F Wozniak, Carla M Yuede, Steven M Paul, Charles F Zorumski, Steven Mennerick

2020-Current year OA Pubs

Brain cholesterol metabolic products include neurosteroids and oxysterols, which play important roles in cellular physiology. In neurons, the cholesterol oxidation product, 24S-hydroxycholesterol (24S-HC), is a regulator of signaling and transcription. Here, we examined the behavioral effects of 24S-HC loss, using global and cell-selective genetic deletion of the synthetic enzyme CYP46A1. Mice that are globally deficient in CYP46A1 exhibited hypoactivity at young ages and unexpected increases in conditioned fear memory. Despite strong reductions in hippocampal 24S-HC in mice with selective loss of CYP46A1 in VGLUT1-positive cells, behavioral effects were not recapitulated in these conditional knockout mice. Global knockout produced strong, developmentally …

Pro-Inflammatory Cerebrospinal Fluid Profile Of Neonates With Intraventricular Hemorrhage: Clinical Relevance And Contrast With Cns Infection, Maria Garcia-Bonilla, Alexander T Yahanda, Albert M Isaacs, Brandon Baksh, S Hassan A Akbari, Haley Botteron, Diego M Morales, Rowland H Han, James P Mcallister Ii, Amit M Mathur, Jennifer M Strahle, Christopher D Smyser, David D Limbrick

2020-Current year OA Pubs

BACKGROUND: Interpretation of cerebrospinal fluid (CSF) studies can be challenging in preterm infants. We hypothesized that intraventricular hemorrhage (IVH), post-hemorrhagic hydrocephalus (PHH), and infection (meningitis) promote pro-inflammatory CSF conditions reflected in CSF parameters.

METHODS: Biochemical and cytological profiles of lumbar CSF and peripheral blood samples were analyzed for 81 control, 29 IVH grade 1/2 (IVH

RESULTS: PHH infants had higher (p < 0.02) CSF total cell and red blood cell (RBC) counts compared to control, IVH

CONCLUSIONS: Similarities in CSF parameters may reflect common pathological processes in the inflammatory response and show the complexity associated with interpreting CSF profiles, especially in PHH and meningitis/ventriculitis.

Well-Being Literacy In The Academic Landscape: Trioethnographic Inquiry Into Scholarly Writing, Narelle Lemon, Jacqui Francis, Lisa M. Baker

Research outputs 2022 to 2026

Writing well and being well as academic writers is rarely spoken about, often hidden, and at times evaded. We believe that developing, maintaining, and growing well-being literacy not only engages the act but also allows awareness, reflection, and metacognitive thinking that enable mindful writing for well-being. Well-being literacy, the capacity to understand and employ well- being language for personal, collective, and global well-being, intrigues us. It encompasses nurturing, sustaining, and safeguarding well-being for individuals, groups, and systems to thrive. As scholars delving into well-being literacy, we, a diverse collective from across higher education career trajectories, investigate its role in scholarly …