Digital Commons Network^™

Factors Influencing Local Control After Mr-Guided Stereotactic Body Radiotherapy (Mrgsbrt) For Adrenal Metastases, Rupesh Kotecha, Tugce Kutuk

All Publications

Purpose: Stereotactic body radiotherapy (SBRT) is an effective treatment for adrenal gland metastases, but it is technically challenging and there are concerns about toxicity. We performed a multi-institutional pooled retrospective analysis to study clinical outcomes and toxicities after MR-guided SBRT (MRgSBRT) using for adrenal gland metastases.

Methods and materials: Clinical and dosimetric data of patients treated with MRgSBRT on a 0.35 T MR-Linac at 11 institutions between 2016 and 2022 were analyzed. Local control (LC), local progression-free survival (LPFS), distant progression-free survival (DPFS) and overall survival (OS) were estimated using Kaplan-Meier method and log-rank test.

Results: A total of 255 …

Pd-1 Inhibition Combined With Intensity-Modulated Radiotherapy, To Better Serve Patients With Retroperitoneal Lymph Node Metastases From Gastrointestinal Cancer, Michael Chuong

All Publications

Background: Gastrointestinal (GI) cancer is the most frequent kind of cancer to involve the retroperitoneal lymph nodes (RPLNs). Radiotherapy (RT) is common treatment of RPLN metastases in patients with GI cancer, while RT is local. Meanwhile, most patients have extra-retroperitoneal metastases. Immunotherapy plus RT have showed effective in advanced non-small cell lung cancer. However, whether the combination therapy is effective on GI cancer with RPLN metastases. In our study, we would estimate the effect of programmed death-1 (PD-1) inhibition in association with intensity modulated radiation therapy (IMRT).

Methods: Metastatic GI cancer patients with RPLN who were treated at a single …

Buffer Zones Through The Lens Of Golf: A Negligence Case Content Analysis, Natalie Bird, Merry Moiseichik

Public Policy Faculty & Graduate Student Publications and Presentations

Buffer zones are a risk management strategy used within sport and recreation to protect participants and spectators from injury. Within the recreational golf sector, buffer zone standards do not exist. Recreational golf courses serve a wide range of customers in terms of age, skill level, and experience. A legal case content analysis of 1,561 golf negligence lawsuits answered research questions related to locations of incidents, circumstances, and injuries or damages that resulted from errant golf shots. A Westlaw search provided 133 cases within the scope of this study, 85 of which could have been possibly prevented with proper buffer zones. …

The Predictive Relationship Between Teachers’ Knowledge Of Dyslexia And Their Confidence In Supporting Students With Dyslexia, Jaimee Rachelle Szymanski

Doctoral Dissertations and Projects

The purpose of this quantitative, correlational study was to explore the relationship between teachers’ knowledge of dyslexia and their confidence in teaching those with dyslexia, as these factors impact teachers’ ability to provide proper interventions and accommodations for students with dyslexia. A lack of knowledge or overconfidence in a teacher’s abilities can negatively impact educational outcomes for these students. The population for this study consisted of 117 public-school teachers in rural Ohio within the Appalachian region. The Knowledge and Beliefs About Developmental Dyslexia Scale and the Teaching Students with Disabilities Efficacy Scale were utilized to collect data in a digital …

A Mixed Methods Study To Evaluate The Nature Of The Lead Pastor's Psychological Capital And The Impact On Leading Church Revitalization, Toney Allen Cox

Doctoral Dissertations and Projects

In response to the substantial amount of church revitalization that is necessary to cause a noteworthy decrease in the 70 percent of churches in America that are declining or plateauing (Rainer, 2019, para. 4), lead pastors carry a biblical responsibility to lead churches into growth and spiritual health (Jamieson, 2011, para. 15-16). While church planting is a respectable portion of the macro solution, revitalizing declining or plateaued existing churches is an equally significant part of the solvent. However, a substantial majority of revitalization literature and education focuses on the practical methodology of implementing church renewal and emphasizing the lead pastor’s …

The Effect Of Formal Mentorship Programs On Nurse Faculty Retention: An Integrative Review, Lisa Livingston

Doctoral Dissertations and Projects

The nursing shortage has been a hot topic for decades, and literature supports a need to address this issue. Although faculty are critical to educating the nurses of the future, the shortage has impacted nurse faculty numbers as well. Nursing shortages are predicted to increase over the next decade. Evidenced-based interventions are critical to help sustain the nursing workforce. This integrative review highlights the importance of formal mentorship programs for new nurse faculty as a retention strategy for use by administrators of schools of nursing.

Male Motivation To Pursue Social Work: A Causal-Comparative Study Investigating The Differences In Male Students’ Motivational Orientation And Field Of Study, Laura A. Dimarcantonio

Doctoral Dissertations and Projects

The purpose of this quantitative, non-experimental, causal-comparative study was to investigate if there is a difference in the motivational orientation of male social work students and men in traditional fields of study. Men are underrepresented in social work degree programs in the United States, yet their unique voice and experience are needed to meet the diverse workforce goals of the profession and provide equitable services to all individuals. Participants for the study were drawn from a convenience sample that included 252 students enrolled in baccalaureate, master’s, and doctoral-level social work, computer science, engineering, and math programs at four universities in …

Understanding The Lived Experiences Of Military-Connected Students Transitioning From The Military Way Of Life To Higher Education: A Qualitative Study, Earnest Kincade

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to better understand the phenomenon of the lived experiences of military-connected students transitioning from the military way of life to higher education. This study was guided by Schlossberg’s 4S theory on transitioning adults as related to situations, self, support, and strategies concerning military-connected students in Alaska. The participants were chosen by criterion sampling to select students based on their military affiliation, who attended the universities in the United States, and who have experienced multiple transitions related to the military lifestyle of their parents. The data collection process involved an initial questionnaire using …

The Effect Of Music On Spiritual Well Being Among Hospice Patients, Mathai Abraham

Doctoral Dissertations and Projects

The life expectancy of a hospice patient is approximately six months or less. Hospice care is not for the cure of the disease. It is the care provided to the patients for the symptom management of the disease. Hospice care, known as end-of-life care, is very important for a comfortable and peaceful passage. Holistic care for the hospice patient is the goal of the hospice care plan. A hospice patient’s spiritual well-being can be maintained by spiritual support through a spiritual presence and spiritual conversation; all hospice care institutions' disciplines can provide adequate spiritual aid through their interaction with patients, …

The Lone Star On Relief: The Story Of The Texas Federal Writers' Project, 1935-1943, Michael William Mitchell

Doctoral Dissertations and Projects

My academic interest in the Federal Writers’ Project (FWP) began in 1993. I have been interested in the Works Progress Administration (WPA) from the time I was in my middle school years listening to stories from my grandmother. As a result, I grew up feeling that the WPA represented a part of a remarkable time and was a fascinating attempt by the far-away national government to help ordinary people in Texas struck down by the Great Depression. While conducting research on my master’s thesis, I met an archivist at the Southern Historical Collection at the University of North Carolina who …

“I Have Nothing Left To Give” A Phenomenological Study Of Secondary Traumatic Stress And Burnout In Urban School Teachers Related To The Socioeconomic Issues, Childhood Trauma, And Low Academic Performance Of Urban Students, Melissa Elizabeth Grazette

Doctoral Dissertations and Projects

This study examines the shared experiences of secondary traumatic stress and burnout in urban schoolteachers in Washington, D.C. This study focuses on the experiences of teachers working in a low-performing school in a low-income neighborhood and working with students with trauma as it relates to their experiences with secondary traumatic stress and burnout symptoms. This study focused on the lived experiences of ten urban schoolteachers in Washington, D.C. The teacher participants served a school population of 68% at risk of negative socioeconomic barriers such as exposure to violence, poverty, drugs, and an increased likelihood of exposure to trauma. The hermeneutic …

Improving Self-Efficacy In Flight Nurse Practitioners In Preparation For The Role Of The Law Enforcement Tactical Nurse Practitioner, Gregory S. Wamack

Doctoral Dissertations and Projects

Current evidence demonstrates that the number of prehospital nurse practitioners working in both civilian and military settings is growing. Additional training beyond the formal nurse practitioner curriculum is necessary to increase the self-efficacy, knowledge, and skills of the nurse practitioner for operational battlefield conditions in far-forward austere and tactical settings. Evidence also demonstrates that the Tactical Combat Casualty Care (TC3) course is the national standard for tactical care and training for all health care providers. The purpose of this evidence-based pilot study was to increase the tactical self-efficacy of the United States based nontactical civilian highly trained and skilled flight …

A Leadership Training Program Improves Nurse Manager Retention, Lisa A. Longley

Doctoral Dissertations and Projects

The need to retain nursing managers is at an all-time high. The turnover rate for a local xxxxxxxxxx (removed to protect privacy) healthcare system is 14% post pandemic compared to 8% pre-pandemic. The nursing management team reported a need for nursing specific management orientation because the current training included all organizational supervisors and covered general concepts, failing to meet the complex needs of frontline nursing managers. Literature confirms that organizations that provide nursing management training develop role competency have higher satisfaction and lower turnover rates. An organizational-specific needs assessment designed within the American Organization of Nursing Leadership competency framework was …

A Qualitative Descriptive Study: What South Carolina Church Leaders Believe About Congregational Active Shooter Preparation, Charles David Watts Jr.

Doctoral Dissertations and Projects

The purpose of this qualitative descriptive study is to establish a baseline of understanding what experiences South Carolina Southern Baptist church leaders have in active shooter training and what they believe about preparing, training, and equipping congregations for an active shooter incident in their house of worship. This researcher examined how church leaders prepare, train, and equip congregations for security threats like active shooter incidents. This study fills a gap in the existing literature, adding to the research by Auten (2021), Rainer (2017), and the FBI (2016). This researcher examined how churches prepare for security threats like active shooter incidents. …

The Lived Experiences Of Women In Higher Education Administrator Roles Through The Salary Negotiation Process At The Time Of Hire: A Phenomenological Study, Nancy Kay Hernandez

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe the experiences of salary negotiation at the time of hire for women in full-time administrator positions at Texas institutions of higher education. Eagly’s social role theory guided this study to explain gender roles and negotiation. A qualitative research design with a phenomenological approach was used to explore the experiences of women in higher education administrator roles during the salary negotiation process. Institutions within the south-central regions of Texas, including public and private colleges and universities, served as the site for this study. Participants were 12 women in full-time administrator positions at …

A Correlational Study Of The Resilience Factors That Promote Mental Health In First Responders, Tamara Rae Grayson

Doctoral Dissertations and Projects

Too often, the title first responder (FR) has been correlated with mental illnesses, such as depression, anxiety, substance use, and posttraumatic stress disorder (PTSD). There was a need to address the mental health of this unique at-risk population prior to developing a mindset that being a FR translates into also suffering from mental illness, due to repeated exposure to traumatic situations. The purpose of this correlational study was to identify the resilience factors in FRs, what unique and untreated exposure to traumatic events looks like in FRs, what normal treatment and early interventions for mental illnesses in FRs is, the …

Teaching The Teachers: A Qualitative Case Study Of First Year Schoolteachers, Matthew Thomas Stone

Doctoral Dissertations and Projects

The purpose of this multiple case study was to understand the challenging experience of first-year teachers at existing classical charter schools in the United States of America. Maslow's theory of human motivation provided the guiding framework into how early year teachers can be effectively supported in schools to prevent attrition, which can have a negative effect on student achievement. This qualitative design utilized a case study approach from two different classical charter schools in the United States of America and featured interviews, journal entries, and the review of first year physical artifacts from ten teachers who are no further than …

Suicide In Black Adolescents: How Does The Relationship And Attachment Styles Impact The Grieving Experience Of Non-Custodial Black Grandmothers, Edith Marie Walton-Carter

Doctoral Dissertations and Projects

The purpose of this descriptive phenomenological study was to gain insight into the relationship and grief experiences of the non-custodial Black/African American grandmother(s) who have lost a grandchild by suicide. The theories guiding this study are attachment theory, psychosocial stages of development, and grief and loss. The central research questions are used to explore the attachment and relationship between the Black grandmother(s) and grandchild(ren) and whether suicide changes the grieving experience. Participants were selected through purposeful sampling. The sample size for this study includes six Black women between the ages of 48-65 who are non-custodial grandmothers and have experienced grief …

A Phenomenological Study Of Resource Parents' Experiences Providing For The Educational Needs Of Children With Adverse Childhood Experiences, Skyler Nicole Wells

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to examine the lived experience that resource parents (e.g., kinship, foster, adoptive) undergo to care for the education needs of their children with adverse childhood experiences (ACEs). The theory guiding this study is Bandura’s theory on social learning (1977). Bandura explained how behaviors and skills from a model were used to guide the central research question: What are the lived experiences of resource parents caring for the educational needs of children with ACEs? Data was collected from 12 adults living in a rural county in Virginia using writing prompts, interviews, and focus …

Dimensionality Reduction: Principal Component Analysis Of Workload Of An Nba Game, Brian Audelio Serrano

Doctoral Dissertations and Projects

The worlds of sports science, data analytics, and sports performance are at a crossroads. Each field is accustomed to functioning in relative silos; however, this approach is quickly becoming outdated. Sporting organizations are adopting high-performance models that integrate all departments and their subsequent data pipelines. This has led to a wealth of information not available before to a team’s performance health staff in guiding optimal athletic performance. Within the sport of basketball, these silos can be split further into video coaching, basketball analytics, sports science, player development, and performance health. Specifically, basketball sports science can be categorized into internal and …

A Phenomenological Study Of Teacher Experiences Personalizing Learning In English Language Arts, Kristen N. Soper

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to understand the lived experiences of secondary English language arts teachers implementing personalized learning in Southeastern Pennsylvania. Teachers who personalize learning must currently determine their own method of doing so without adequate research about the process to inform their pedagogy. The theory guiding this study was Vygotsky’s theory on social development, as it highlights the necessity of social interaction to help students stay within the zone of proximal development even in a personalized learning framework. The ten participants for this study were selected by purposive sampling, and data were collected through semi-structured …

Pan-Cancer Proteogenomics Characterization Of Tumor Immunity, Francesca Petralia, Weiping Ma, Tomer M Yaron, Francesca Pia Caruso, Nicole Tignor, Joshua M Wang, Daniel Charytonowicz, Jared L Johnson, Emily M Huntsman, Giacomo B Marino, Anna Calinawan, John Erol Evangelista, Myvizhi Esai Selvan, Shrabanti Chowdhury, Dmitry Rykunov, Azra Krek, Xiaoyu Song, Berk Turhan, Karen E Christianson, David A Lewis, Eden Z Deng, Daniel J B Clarke, Jeffrey R Whiteaker, Jacob J Kennedy, Lei Zhao, Rossana Lazcano Segura, Harsh Batra, Maria Gabriela Raso, Edwin Roger Parra, Rama Soundararajan, Ximing Tang, Yize Li, Xinpei Yi, Shankha Satpathy, Ying Wang, Maciej Wiznerowicz, Tania J González-Robles, Antonio Iavarone, Sara J C Gosline, Boris Reva, Ana I Robles, Alexey I Nesvizhskii, D R Mani, Michael A Gillette, Robert J Klein, Marcin Cieslik, Bing Zhang, Amanda G Paulovich, Robert Sebra, Zeynep H Gümüş, Galen Hostetter, David Fenyö, Gilbert S Omenn, Lewis C Cantley, Avi Ma'ayan, Alexander J Lazar, Michele Ceccarelli, Pei Wang, Clinical Proteomic Tumor Analysis Consortium

Faculty, Staff and Student Publications

Despite the successes of immunotherapy in cancer treatment over recent decades, less than <10%-20% cancer cases have demonstrated durable responses from immune checkpoint blockade. To enhance the efficacy of immunotherapies, combination therapies suppressing multiple immune evasion mechanisms are increasingly contemplated. To better understand immune cell surveillance and diverse immune evasion responses in tumor tissues, we comprehensively characterized the immune landscape of more than 1,000 tumors across ten different cancers using CPTAC pan-cancer proteogenomic data. We identified seven distinct immune subtypes based on integrative learning of cell type compositions and pathway activities. We then thoroughly categorized unique genomic, epigenetic, transcriptomic, and proteomic changes associated with each subtype. Further leveraging the deep phosphoproteomic data, we studied kinase activities in different immune subtypes, which revealed potential subtype-specific therapeutic targets. Insights from this work will facilitate the development of future immunotherapy strategies and enhance precision targeting with existing agents.

An Independent Analysis Of A Retrospective Cohort Of 30,423 Covid-19 Patients Treated At Ihu-Mediterranean In Marseille, France: Part 1, Efficacy Of Early Treatment With Hydroxychloroquine And Azithromycin, Valere Lounnas, Eleftherios Gkioulekas, Marc Rendell, Alexis Lacout, Xavier Azalbert, Christian Perronne

School of Mathematical & Statistical Sciences Faculty Publications

A cohort of 30,423 Covid-19 patients treated between March 2020 and December 2021 at the IHU-Méditerranée Infection in Marseille (France) was retrospectively analyzed in terms of treatment attempted and disease worsening factors to quantify efficacy with respect to the composite endpoint of transfer to intensive care unit or death, within a couple of months (56 days) from admission. Within limitations of the data and of the models, after adjustment for sampling biases, multivariate logistic regression analyses were performed to determine unadjusted and adjusted odds ratios (ORs) for the subset of patients having received the combined treatment hydroxychloroquine plus azithromycin (HCQ-AZ) …

An Independent Analysis Of A Retrospective Cohort Of 30,423 Covid-19 Patients Treated At Ihu-Mediterranean In Marseille, France: Part 2, A Real-Life Assessment Of Covid-19 Vaccination Efficacy, Valere Lounnas, Eleftherios Gkioulekas, Marc Rendell, Alexis Lacout, Xavier Azalbert, Christian Perronne

School of Mathematical & Statistical Sciences Faculty Publications

A cohort of 30,423 Covid-19 patients treated between March 2020 and December 2021 at the IHU-Méditerranée Infection in Marseille (France) was retrospectively analyzed in terms of treatment attempted and disease worsening factors to quantify vaccination efficacy with respect to the composite endpoint of transfer to intensive care unit or death, within a couple of months (56 days) from admission. Within limitations of the data and of the models, after adequate adjustment for sampling biases, multivariate logistic regression analyses were performed to determine unadjusted and adjusted odds ratios (ORs) for the subset of patients admitted after the Covid-19 vaccination program was …

Effect Of Social Media Influencers On Generation Y Purchase Intention: Evidence From Men’S Skincare Products In Malaysia, Siew Yong Leong, Man Yee Yip, Chi Hau Tan, Man Seong Chan

International Journal of Management, Finance and Accounting

Although the demand for men’s skincare products is becoming increasingly popular in Malaysia, previous studies of social media marketing have shed little light on the effect of social media influencers on men’s skincare purchase intention. Therefore, this research investigates the effects of social media influencers’ attractiveness, trustworthiness, expertise, likability, similarity, and familiarity on purchase intention in men’s skincare products among Generation Y in Malaysia. An online questionnaire was implemented, and 279 respondents were gathered using the snowball sampling technique. After obtaining the desired responses, multiple regression analysis was adopted to examine the research model and hypotheses. The findings showed that …

A Scoping Review Of Artificial Intelligence In Medical Education: Beme Guide No. 84, Morris Gordon, Janice Hanson, Et Al.

2020-Current year OA Pubs

BACKGROUND: Artificial Intelligence (AI) is rapidly transforming healthcare, and there is a critical need for a nuanced understanding of how AI is reshaping teaching, learning, and educational practice in medical education. This review aimed to map the literature regarding AI applications in medical education, core areas of findings, potential candidates for formal systematic review and gaps for future research.

METHODS: This rapid scoping review, conducted over 16 weeks, employed Arksey and O'Malley's framework and adhered to STORIES and BEME guidelines. A systematic and comprehensive search across PubMed/MEDLINE, EMBASE, and MedEdPublish was conducted without date or language restrictions. Publications included in …

The Global Landscape Of Immune-Derived Lncrna Signature In Colorectal Cancer, Mengying Zhang, Yifei Wu, Jingyi Mou, Yang Yao, Pengbo Wen, Xin Liu, Shipeng Shang, Xingxing Kang, Jiaqi Tian, Yan Liu, Enhui Lv, Liang Wang

Research outputs 2022 to 2026

Background: Colorectal cancer (CRC) is a highly heterogeneous cancer. This heterogeneity has an impact on the efficacy of immunotherapy. Long noncoding RNAs (lncRNAs) have been found to play regulatory functions in cancer immunity. However, the global landscape of immune-derived lncRNA signatures has not yet been explored in colorectal cancer. Methods: In this study, we applied DESeq2 to identify differentially expressed lncRNAs in colon cancer. Next, we performed an integrative analysis to globally identify immune-driven lncRNA markers in CRC, including immune-associated pathways, tumor immunogenomic features, tumor-infiltrating immune cells, immune checkpoints, microsatellite instability (MSI) and tumor mutation burden (TMB). Results: We also …

Postoperative Atrial Fibrillation (Poaf) After Cardiac Surgery: Clinical Practice Review, Orlando R Suero, Ahmed K Ali, Lauren R Barron, Matthew W Segar, Marc R Moon, Subhasis Chatterjee

Faculty, Staff and Students Publications

Postoperative atrial fibrillation (POAF) after cardiac surgery is associated with elevated morbidity and mortality. Although current prediction models have limited efficacy, several perioperative interventions can reduce patients' risk of POAF. These begin with preoperative medications, including beta-blockers and amiodarone. Moreover, patients should be screened for preexisting atrial fibrillation (AF) so that concomitant surgical ablation and left atrial appendage occlusion can be performed in appropriate candidates. Intraoperative interventions such as posterior pericardiectomy can reduce mediastinal fluid accumulation, which is a trigger for POAF. Furthermore, many preventive strategies for POAF are implemented in the immediate postoperative period. Initiating beta-blockers, amiodarone, or both …

The Grizzly, February 29, 2024, Marie Sykes, Sidney Belleroche, Sophia Kumar, Ellie Burns, Kate Horan, Renie Christensen, Andrew J. Perez, Dan Bass, Adam Denn

Ursinus College Grizzly Newspaper, 1978 to Present

Dr. Harold Dean Trulear Talks Theology and Mass Incarceration • Newly Created Performing and Visual Arts Design and Technology Major • Ursinus Crossword Puzzle • Reimagine Ursinus-Collegeville: Planting a Seed of Change • Spring at Ursinus College Word Search • Meme Corner • Taco Tuesday! • UCWB Playoff Run Comes to an End in Baltimore • "Pool Party at Gettysburg!" Bears Accept Invitation

Genetic Algorithm For Automated Parameterization Of Network Hamiltonian Models Of Amyloid Fibril Formation, Gianmarc Grazioli, Andy Tao, Inika Bhatia, Patrick Regan

Faculty Research, Scholarly, and Creative Activity

The time scales of long-time atomistic molecular dynamics simulations are typically reported in microseconds, while the time scales for experiments studying the kinetics of amyloid fibril formation are typically reported in minutes or hours. This time scale deficit of roughly 9 orders of magnitude presents a major challenge in the design of computer simulation methods for studying protein aggregation events. Coarse-grained molecular simulations offer a computationally tractable path forward for exploring the molecular mechanism driving the formation of these structures, which are implicated in diseases such as Alzheimer’s, Parkinson’s, and type-II diabetes. Network Hamiltonian models of aggregation are centered around …