Digital Commons Network^™

The Emerging Importance Of Skull-Brain Interactions In Traumatic Brain Injury, Peixi Zhao, Rui Jin, Bin Zhao, Le Han, Wenjuan Chen, Nina Hao, Yi Cui, Ankit Madan, Joy Awosika, Shane Lloyd, Yili Zhang

Faculty, Staff and Student Publications

Background and Objective

Immune checkpoint inhibitors (ICIs) have been widely applied and studied in the treatment of gastrointestinal (GI) cancers, and have achieved good results. However, in clinical practice, it has been observed that only some patients respond well to ICIs, and some patients may experience various degrees of adverse reactions during the treatment. Timely evaluation of the potential therapeutic effects and adverse reactions of ICIs for patients has important clinical significance. This review aimed to summarize recent progress regarding efficacy-associated biomarkers for ICIs in GI cancer.

Methods

The literature on ICI treatment in GI cancers was searched in the …

Quantification Of Surface-Localized And Total Oxytocin Receptor In Myometrial Smooth Muscle Cells, Yingye Fang, Erin L Reinl, Audrey Liu, Trinidi D Prochaska, Manasi Malik, Antonina I Frolova, Sarah K England, Princess I Imoukhuede

2020-Current year OA Pubs

Oxytocin acts through the oxytocin receptor (OXTR) to modulate uterine contractility. We previously identified OXTR genetic variants and showed that, in HEK293T cells, two of the OXTR protein variants localized to the cell surface less than wild-type OXTR. Here, we sought to measure OXTR in the more native human myometrial smooth muscle cell (HMSMC) line on both the cell-surface and across the whole cell, and used CRISPR editing to add an HA tag to the endogenous OXTR gene for anti-HA measurement. Quantitative flow cytometry revealed that these cells possessed 55,000 ± 3200 total OXTRs and 4900 ± 390 cell-surface OXTRs …

The Card8 Inflammasome Dictates Hiv/Siv Pathogenesis And Disease Progression, Qiankun Wang, Kolin M Clark, Ritudhwaj Tiwari, Nagarajan Raju, Gregory K Tharp, Jeffrey Rogers, R Alan Harris, Muthuswamy Raveendran, Steven E Bosinger, Tricia H Burdo, Guido Silvestri, Liang Shan

2020-Current year OA Pubs

While CD4

Loss Of Cd20 Expression As A Mechanism Of Resistance To Mosunetuzumab In Relapsed/Refractory B-Cell Lymphomas, Stephen J Schuster, Nancy L Bartlett, Et Al.

2020-Current year OA Pubs

CD20 is an established therapeutic target in B-cell malignancies. The CD20 × CD3 bispecific antibody mosunetuzumab has significant efficacy in B-cell non-Hodgkin lymphomas (NHLs). Because target antigen loss is a recognized mechanism of resistance, we evaluated CD20 expression relative to clinical response in patients with relapsed and/or refractory NHL in the phase 1/2 GO29781 trial investigating mosunetuzumab monotherapy. CD20 was studied using immunohistochemistry (IHC), RNA sequencing, and whole-exome sequencing performed centrally in biopsy specimens collected before treatment at predose, during treatment, or upon progression. Before treatment, most patients exhibited a high proportion of tumor cells expressing CD20; however, in 16 …

Integrin Α9Β1 Deficiency Does Not Impact The Development Of Atherosclerosis In Mice, In-Hyuk Jung, Nathan O Stitziel

2020-Current year OA Pubs

Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (SVEP1) is an extracellular matrix protein that causally promotes cardiovascular disease in humans and mice. However, the receptor mediating the effect of SVEP1 on the development of disease remains unclear. We previously demonstrated that depleting either vascular smooth muscle cell (VSMC)- or myeloid cell-derived integrin α9β1, the first receptor that was identified to interact with SVEP1, did not phenocopy the disease-abrogating effect of depleting SVEP1. Due to its wide expression in tissues and cell types, here we extend this line of investigation to definitively determine if integrin α9β1 …

The Card8 Inflammasome Dictates Hiv/Siv Pathogenesis And Disease Progression, Qiankun Wang, Kolin M Clark, Ritudhwaj Tiwari, Nagarajan Raju, Gregory K Tharp, Jeffrey Rogers, R Alan Harris, Muthuswamy Raveendran, Steven E Bosinger, Tricia H Burdo, Guido Silvestri, Liang Shan

Faculty, Staff and Students Publications

While CD4+ T-cell depletion is key to disease progression in people living with HIV and SIV-infected macaques, the mechanisms underlying this depletion remain incompletely understood, with most cell death involving uninfected cells. In contrast, SIV infection of “natural” hosts such as sooty mangabeys do not cause CD4+ depletion and AIDS despite high-level viremia. Here, we report that the CARD8 inflammasome is activated immediately after HIV entry by the viral protease encapsulated in incoming virions. Sensing of HIV protease activity by CARD8 leads to rapid pyroptosis of quiescent cells without productive infection, while T-cell activation abolishes CARD8 function and increases permissiveness …

Vkorc1 Polymorphisms And Complete Resistance To Vitamin K Antagonists: About Two Cases., Ilham Benyamna, Houda El Fissi, Fadoua Bouzid, Abdelhamid El Mousadik, Najat Alif

BioMedicine

Complete resistance to vitamin K antagonists is a rare but serious. It can complicate therapeutic management, especially when direct oral anticoagulants cannot be used. Some single mutations in the VKORC1 gene have been identified in patients partially or completely resistant to vitamin K antagonists. We report the cases of two women in their fifties who presented an unexplained peripheral venous thrombosis. The aetiological assessment did not show any abnormalities. Genetic testing showed that both patients had the VKORC1 5417GG genotype. The VKORC1 3673 genotype was GG in case 1 and GA in case 2. The two patients showed complete resistance …

Computational Analysis Of Dimer G6pd Structure To Elucidate Pathogenicity Of G6pd Variants, Shamini Chandran, Naveen Eugene Louis, Syazwani Itri Amran, Nurriza Ab Latif, Muaawia Ahmed Hamza, Mona Alonazi

BioMedicine

An inherent genetic enzyme disorder in humans, known as glucose-6-phosphate dehydrogenase (G6PD) deficiency, arises due to specific mutations. While the prevailing approach for investigating G6PD variants involves biochemical analysis, the intricate structural details remain limited, impeding a comprehensive understanding of how different G6PD variants of varying classes impact their functionality. This study examined the dynamic properties of G6PD wild types and six G6PD variants from different classes using molecular dynamic simulation (MDS). The wild-type and variant G6PD structures unveil high fluctuations within the amino acid range of 274-515, the structural NADP⁺ binding site, pivotal for enzyme dimerization. Specifically, two …

Ethanol Leaf Extracts Of Anogeissus Leiocarpus In Antioxidants And Hepatotoxic Effects Of Escherichia Coli Infected Swiss Mice, Fred Coolborn Akharaiyi, Chioma Bertha Ehis-Eriakha, Peter Taiwo Olagbemide, Stephen Eromosele Akemu

BioMedicine

Introduction: Diseases caused by bacteria can be managed with medicinal plants with rightful dosage that will not affect body physiology and organs.

Aim: This research aimed to evaluate the antioxidants and the effects of Anogeisus leiocarpus on liver function.

Materials and Methods: Ethanol leaf extracts were processed for antioxidants and hepatotoxic effects using animal models. Group one (negative control) was given access to water and regular feed, group two (positive control) was dosed with 107 CFU/ml of Escherichia coli O157:H7, and groups 3-6 were dosed with 107 E. coli O157:H7 for 3 days and treated with extract concentrations of 12, …

Impact And Prevalence Of Comorbidities And Complications On The Severity Of Covid-19 In Association With Age, Gender, Obesity, And Pre-Existing Smoking: A Meta-Analysis, Soulandi Djorwé, Amale Bousfiha, Néhémie Nzoyikorera, Joseph Nyandwi, Bellamine Kawthar, Abderrahim Malki

BioMedicine

Background: COVID-19 patients usually present multiple comorbidities and complications associated with severe forms of SARS-CoV-2 infection. This study aimed to assess the risk factors and prevalence of comorbidities and complications contributing to the severity of COVID-19.

Methods: This meta-analysis was performed according to PRISMA guidelines. We searched various databases, including PubMed, Google Scholar, and Scopus (between 2020 and 2023), for eligible studies for this meta-analysis.

Results: Thirty-three studies were eligible, including 85812 patients, of which 36% (30634/85812) had severe disease, whereas 64% (55178/85812) had non-severe disease. Severe cases were potentially correlated with the following factors: gender (male) (odd ratio (OR) …

Biomedicines In Longevity And Aging The Quest To Resist Biological Decline, Raymond D D Raymond

BioMedicine

Aging is considered part of the natural process of life, however in recent years medical literature has started to show that specific facets of aging are beginning to be understood and those specific factors may even be considered preventable with various measures as this paper will demonstrate. Aging is also considered the number one cause of poor quality of life, disease, disability, and death, so the importance of understanding the aging process and how to control certain aspects of it cannot be underestimated when age related suffering is factored in. The causes of aging are now becoming well understood, and …

A Brief Literature Review Of Low-Level Laser Therapy For Treating Amyotrophic Lateral Sclerosis And Confirmation Of Its Effectiveness, Sergey Vladimirovich Moskvin

BioMedicine

Introduction: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a steadily progressive course due to the death of central and peripheral motor neurons responsible for voluntary movements. Low-level laser therapy (LLLT) is a treatment method unique in its universality and efficacy, particularly for neurodegenerative diseases.

Methods: In this review, we discuss the effect and application of LLLT in the treatment of ALS. A literature search for English and Russian publications for the keywords "Amyotrophic Lateral Sclerosis", "Low-Level Laser Therapy" was performed using PubMed, Scopus, Google Scholar, Web of Science and Russian Science Citation Index (RSCI) databases.

Results: The article …

Editorial Board And Call For Submissions

Journal of Graduate Education Research

No abstract provided.

A Geographical Lens On Rural Teacher Induction And Retention, Quinn A. Abbate

Journal of Graduate Education Research

Induction is a critical phase for early career teachers (ECTs) because it is where they develop their sense of professional identity and often decide whether or not to stay in the profession. Substantial research has reported high rates of rural teacher retention during induction (e.g., Ingersoll & Strong, 2011), but few researchers have examined this pattern through a geographical lens. Rural education theorists Gruenewald (2003) and Reid et al. (2010) suggest that a geographical lens is a useful way to understand the complexities of place and space—particularly rural space. Rooted in their theories, the present study aimed to address the …

The Relationship Between Social Media Use, Internet Use, And Frequency Of Pornography Habits, Chaela Hastings, Anna Miller

Journal of Graduate Education Research

The purpose of this correlational study is to determine whether or not there is a relationship between the amount of time spent on the internet or social media sites and the frequency of pornography habits, and if gender has an effect on frequency of pornography habits. Participants were a convenience sample of 105 men and women between ages 18-24 among two universities in the Southeastern United States. Each participant completed a survey to determine time spent on internet sites, time spent on social media, and the frequency of pornography habits. An analysis of our results showed that there is not …

“It’S Been A Long And Terrible Day”: Doctoral Students’ Experience Of Stress And Coping, Orianna D. Carvalho, Yarisbel Melo Herrera, Jiangping Cai, Mardoche W. Telusma, Qingyu Yang, Brenda Santos, Jacquelyn Potvin, Bobby Gondola, Elizabeth-Ann Rando Viscione, Jodi Sutherland Charvis, Joise Garzon, Hayley Lindsey, Aradhana Aradhana, Annemarie Vaccaro Dr.

Journal of Graduate Education Research

Research has shown that graduate students experience a host of stressors as they navigate higher education. This study was a participant-generated visual method (PGVM) project with 14 doctoral students from one research university in the northeastern United States. The purpose of this study was to illuminate doctoral students’ experiences as the world was progressing toward a post-pandemic reality. Data sources included visual image solicitation, a focus group interview, and individual memoing over one semester. Several themes emerged, including stressors related to working while in graduate school, finances, and social challenges. This study offers insights to graduate programs seeking to reduce …

Challenging Elitism In Higher Education And Graduate Employability: A Thinking Piece, Bushra Baboo Rally

Journal of Graduate Education Research

This paper critically examines the prevalence of elitism in higher education and the complex challenge it posits for graduate employability. Several sections of this paper explore the concept of elitism through the lens of positional conflict theory and narrow it down to the relative graduate employability challenges that are experienced due to various factors. The current paper contributes to knowledge since the existing pool of literature does not tackle, in isolation, the function of elitism in posing employment challenges for recent graduates and is not expressed in the current conceptualisations selected in this paper. The paper ends with a call …

Gender, Graduate School Stage, And The Impostor Phenomenon, John-Scott B. Kelley, Angela T. Barlow

Journal of Graduate Education Research

The impostor phenomenon (IP) includes five central factors: (a) a sense of fraudulence or phoniness; (b) a fear of failure and discovery; (c) compensatory perfectionism (i.e., procrastination and/or over-preparation); (d) interpersonal anxiety; and (e) externalized success and/or discounted positive feedback. After the final stage, the process starts over with reinforced vigor, creating a self-reinforcing cycle in which success is associated with psychological suffering. IP was initially used to describe the reports of high-achieving women, but recent studies have shown that IP is experienced across genders. Additionally, while graduate school is an achievement-oriented environment with many characteristics that could promote IP, …

Effects Of Occupational Violence And Aggression On Teacher Wellbeing In Australian Schools: A Meta-Analysis, Anthea L. Hickey Miss

Journal of Graduate Education Research

Occupational violence and aggression (OVA) is an extremely prevalent and concerning issue in all school contexts around the world. International research highlights high prevalence rates of OVA against teachers and identifies a wide range of alarming impacts of OVA on teacher wellbeing. These impacts include risk of anxiety, depression, PTSD, poor sleep, stress, burnout, poor job performance and leaving the profession. The topic of OVA in Australia has been increasing in the media over recent years, as well as the introduction of new OVA prevention strategies. A systematic literature review was conducted to critically analyse and synthesise all of the …

“Roadblocks And Passageways”: Pandemic Lessons For Helping Graduate Students Survive And Thrive In Times Of Crisis, Eunsong Park, Corey S. Shdaimah, Nikita Aggarwal, Amy Garzón-Hampton

Journal of Graduate Education Research

Graduate students and universities continue to be challenged by the COVID-19 pandemic. This qualitative study explored how U.S. graduate students (n=19) experienced and navigated pandemic challenges to their education using by Pierre Bourdieu’s concepts of habitus, capital, and field. Respondents’ abilities to manage changes caused by the pandemic were largely dependent on the capital they or their informal networks had and the field where they positioned during pre-pandemic and pandemic. Institutions’ characteristics and supports greatly influenced students’ habitus and sense of belonging. Study respondents’ ability to maintain their educational trajectories was tied to both their assessment of their institution as …

Psychosocial Aspects Of Academic Life, Kimberley Sartain

Journal of Graduate Education Research

No abstract provided.

Full Issue

Journal of Graduate Education Research

No abstract provided.

Analisis Deskriptif Strategi Komunikasi Politik Dengan Platform Digital (Studi Pada Paslon Ganjar Pranowo Dan Mahfud Md Pada Pemilu Republik Indonesia Tahun 2024), Futihat Nurul Karimah

Jurnal Sosial Humaniora Terapan

This research aims to analyze the political communication strategies carried out by the candidate pair Ganjar Pranowo and Mahfud MD through digital platforms, namely social media in the period 13-19 November 2023.

The use of social media in the digital era is becoming increasingly massive, in a political context, social media can used as a political communication medium to convey political messages. In this research, a descriptive analysis was carried out to understand the effectiveness of the political communication strategy of the Ganjar - Mahfud candidate pair, which focused on the public response to the political communication strategy carried out …

Open Pedagogy Drop-In Session, Denise Lowe, Keven Corcoran

Open Ed Live

Join this session on Open Pedagogy and bring your questions! In this safe and informal space, facilitators are ready to receive your questions regarding open pedagogy benefits and practical implementation practices. This session does not include a formal presentation; instead, attendees will ask questions and facilitators will guide discussion on topics related to open pedagogy.

Illinois Masonic Hospital News Items, 1950 March, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Hospital, Chicago, IL: Informational publication about Illinois Masonic Hospital. This issue has general information about lodges associated with the hospital, the annual meeting of the hospital association, and a list of students in the latest capping ceremony of the nursing school.

This is the first issue that has been collected.

Illinois Masonic Hospital News, 1952 December, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Hospital, Chicago, IL: Informational publication about Illinois Masonic Hospital. This issue has a feature on the recovery room and post-operative care, as well as fundraising information and an announcement of a new glove sterilizer.

Illinois Masonic Hospital News, 1953 November, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Hospital, Chicago, IL: Informational publication about Illinois Masonic Hospital. This issue has photograph sand information from the semi-annual course on reconstructive nasal surgery, an announcement of the new X-Ray Technicians school, as well as fundraising information and other news.

Does All Work And No Play Make Me A Winner? Institutionalized Perceptions Of Hours Worked And Athletic Program Success, Matt R. Huml, Elizabeth A. Taylor, Calvin Nite, Jacob Ackermann, Elenor Ishida

Journal of Issues in Intercollegiate Athletics

The belief that more hours worked equate to higher levels of success has been institutionalized within sport. However, research has yet to interrogate this taken for granted notion. The current study examined the relationship between hours worked and athletic department success. Data were drawn from college coaches and athletic administrators in the United States and consisted of self-reported work hours, team postseason appearances, Directors’ Cup points, and Directors’ Cup rankings to determine if higher work hours were predictive of success. This study also examined the moderated effects of work/family conflict between gender and number of hours worked. The findings show …

The Making Of Modern-Day Nil Laws: The Past, Present, And Future Of Amateurism And Commercialization In College Sport, W. Andrew Czekanski, Amanda Siegrist

Journal of Issues in Intercollegiate Athletics

The purpose of this study was to increase the understanding of state laws governing collegiate student-athletes’ name, image, and likeness (NIL) rights and place the laws within the framework of the NCAA’s historic and current views on amateurism and commercialization. To accomplish such, a content analysis of the 30 existing NIL laws/executive orders was performed to identify trends in the statutes and establish what commonalities and differences exist across states. The analysis found five themes/sections common across state laws (i.e., definitions, basic NIL rules, limitations, disclosures and review processes, agent and representation rules, and required workshops). Moreover, the evaluation revealed …

Learning By Doing: College Students Promoting Children’S Philosophical Inquiry In Schools, Margaret Gichuru, Lin Lin, Mecke E. Nagel

The SUNY Journal of the Scholarship of Engagement: JoSE

This focus group study explores the perceptions and experiences of college students working within an applied learning program during the COVID-19 pandemic. The program engages children from prekindergarten to sixth grade in local schools and early childhood education centers. The college students serve as teaching assistants in the SG Program hosted by an academic department in a northeastern university and lead philosophical inquiries as they read picture books. Informed by philosophical inquiry with children and the applied learning principles as the research framework, this focus group study invites five teaching assistants to three one-hour in-depth semi-structured interviews. The analysis of …