Digital Commons Network^™

Prognostic Significance Of Central Skull Base Remodeling In Chiari Ii Malformation, John T Freiling, Nilesh K Desai, Stephen F Kralik, William E Whitehead, Thierry A G M Huisman

Faculty, Staff and Students Publications

Background and purpose: Outward convexity of the basiocciput and posterior atlanto-occipital membrane are common in patients with Chiari II malformation associated with an open neural tube defect. We aimed to determine if the severity of these findings correlated with the need for future hydrocephalus treatment.

Materials and methods: A retrospective chart and imaging review identified patients who underwent open neural tube defect repair at a quaternary care pediatric hospital from July 2014 through September 2022. Patients were classified by the need for hydrocephalus treatment and whether they received prenatal or postnatal neural tube defect repair. Measurements of imaging parameters related …

Mir-574-5p Activates Human Tlr8 To Promote Autoimmune Signaling And Lupus, Tao Wang, Dan Song, Xuejuan Li, Yu Luo, Dianqiang Yang, Xiaoyan Liu, Xiaodan Kong, Yida Xing, Shulin Bi, Yan Zhang, Tao Hu, Yunyun Zhang, Shuang Dai, Zhiqiang Shao, Dahan Chen, Jinpao Hou, Esteban Ballestar, Jianchun Cai, Feng Zheng, James Y Yang

Faculty, Staff and Student Publications

Endosomal single-stranded RNA-sensing Toll-like receptor-7/8 (TLR7/8) plays a pivotal role in inflammation and immune responses and autoimmune diseases. However, the mechanisms underlying the initiation of the TLR7/8-mediated autoimmune signaling remain to be fully elucidated. Here, we demonstrate that miR-574-5p is aberrantly upregulated in tissues of lupus prone mice and in the plasma of lupus patients, with its expression levels correlating with the disease activity. miR-574-5p binds to and activates human hTLR8 or its murine ortholog mTlr7 to elicit a series of MyD88-dependent immune and inflammatory responses. These responses include the overproduction of cytokines and interferons, the activation of STAT1 signaling …

Implementation And Evaluation Of Iron Deficiency Anemia Content In Prenatal Education Classes, Jasmine N. Walker Bsn, Erin M. Morris Bsn, Carrie Harvey Phd, Aprn, Acnp-Bc, Chfn, Mary K. Fouquier Phd, Aprn, Cnm, Facnm

Doctor of Nursing Practice Projects

Purpose/Background

The purpose of this quality improvement project is to provide and increase educational awareness and knowledge regarding iron deficiency anemia (IDA) in pregnant patients at an urban primary care clinic in Memphis, TN. This project is intended to decrease the number of individuals with IDA in pregnancy while decreasing the occurrence of IDA-related complications in pregnancy. The study aimed to introduce a cost-effective approach to help decrease or eradicate complications related to IDA during pregnancy.

The World Health Organization (WHO) estimates the prevalence of anemia-complicating pregnancies to be more than 40 percent. Pregnant women with IDA residing in low …

Pharmacologic Management Of Postpartum Hemorrhage In An Urban Hospital, Jessica Summer Martin Bsn, Rn, Alison Brubaker Doyle Bsn, Rn, Lacey Camille Ballard Bsn, Rn, Stephanie Marie Maupin Bsn, Rn, Kate Fouquier Phd, Aprn, Cnm, Facnm

Doctor of Nursing Practice Projects

This retrospective chart review examined female patients (N=25) who had a postpartum hemorrhage. Electronic medical records from Regional One Health were queried for ICD-10 072 related codes from January 1, 2021-October 31, 2023. Of those, a maximum of 25 charts were identified and the information was deidentified. All data was de-identified, coded, encrypted, housed, and locked securely. Selected records that met the above criteria were then queried for the following: Baseline demographics, gravida, para, amount of blood loss, pharmacological and non-pharmacological interventions, and timing of tranexamic acid (TXA) administration. Data was imported into MS Excel and statistical analysis was conducted …

The Effectiveness Of Dexmedetomidine In The Reduction Of Postoperative Delirium In Patients Over 65: A Scoping Review, Jacqueline Renee Breuer, Michael G. Callonas, Kathleen Chmelicek, Laura Elizabeth Denman, Dwayne Accardo Dnp, Crna, Faana

Doctor of Nursing Practice Projects

Purpose/Background

Postoperative delirium impacts as many as 51% of surgical patients, resulting in increased mortality and morbidity, longer hospital stays, and increased healthcare costs. Adults ≥ 65 have a high risk for developing delirium. This scoping review examines the use of dexmedetomidine in the perioperative period in adults ≥ 65 years old to prevent and treat postoperative delirium.

Methods

Using relevant inclusion criteria, an extensive review of the literature was performed from September through November 2022, utilizing the Cochrane, CINAHL, ClinicalKey, PubMed, and Embase databases. Search phrases included: dexmedetomidine infusion, dexmedetomidine, intraoperative dexmedetomidine, postoperative delirium, older adults, and elderly delirium. …

The Rider (2024-04-08), Natalie Lapsley

The Rider Archives

Vol.9 No.26

The Free Press Vol. 55, Issue 10, 04-08-2024, Dakota Eddy

Free Press, The

Student Opinion Piece: Campus Police Body Cameras--RA Interviews for NSEAW--Volunteer Opportunities--Games and Activities--MovieTalk--Shanks Shatters School Record

An Analysis On The Impact Of Normalized Difference Vegetation Index (Ndvi) Changes On The Land Surface Temperature (Lst) Using Satellite Imagery In The West Bank, Palestine An Analysis On The Impact Of Normalized Difference Vegetation Index (Ndvi) Changes On The Land Surface Temperature (Lst) Using Satellite Imagery In The West Bank, Palestine, Ahmed Ghodieh

Journal of Arts and Social Sciences

Abstract

Board Of Directors Meeting Minutes (April 8, 2024), Dmacc

Board of Directors Meeting Minutes

No abstract provided.

The Roles Of Ferroptosis In Cancer: Tumor Suppression, Tumor Microenvironment, And Therapeutic Interventions, Guang Lei, Li Zhuang, Boyi Gan

Faculty, Staff and Student Publications

In cancer treatment, the recurrent challenge of inducing apoptosis through conventional therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to explore alternative cell death pathways. Ferroptosis, an iron-dependent form of regulated cell death triggered by the lethal accumulation of lipid peroxides on cellular membranes, has emerged as one such promising frontier in oncology. Induction of ferroptosis not only suppresses tumor growth but also holds potential for augmenting immunotherapy responses and surmounting resistance to existing cancer therapies. This review navigates the role of ferroptosis in tumor suppression. Furthermore, we delve into the complex role of ferroptosis within the …

Arid1a Orchestrates Swi/Snf-Mediated Sequential Binding Of Transcription Factors With Arid1a Loss Driving Pre-Memory B Cell Fate And Lymphomagenesis, Darko Barisic, Christopher R Chin, Cem Meydan, Matt Teater, Ioanna Tsialta, Coraline Mlynarczyk, Amy Chadburn, Xuehai Wang, Margot Sarkozy, Min Xia, Sandra E Carson, Santo Raggiri, Sonia Debek, Benedikt Pelzer, Ceyda Durmaz, Qing Deng, Priya Lakra, Martin Rivas, Christian Steidl, David W Scott, Andrew P Weng, Christopher E Mason, Michael R Green, Ari Melnick

Faculty, Staff and Student Publications

ARID1A, a subunit of the canonical BAF nucleosome remodeling complex, is commonly mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal center (GC) response, facilitating cooperative and sequential binding of PU.1 and NF-kB at crucial genes for cytokine and CD40 signaling. The absence of ARID1A tilts GC cell fate toward immature IgM+CD80-PD-L2- memory B cells, known for their potential to re-enter new GCs. When combined with BCL2 oncogene, ARID1A haploinsufficiency hastens the progression of aggressive follicular lymphomas (FLs) in mice. Patients with FL with ARID1A-inactivating mutations preferentially display an immature memory B cell-like state with …

Smarca4 Is A Haploinsufficient B Cell Lymphoma Tumor Suppressor That Fine-Tunes Centrocyte Cell Fate Decisions, Qing Deng, Priya Lakra, Panhong Gou, Haopeng Yang, Cem Meydan, Matthew Teater, Christopher Chin, Wenchao Zhang, Tommy Dinh, Usama Hussein, Xubin Li, Estela Rojas, Weiguang Liu, Patrick K Reville, Atish Kizhakeyil, Darko Barisic, Sydney Parsons, Ashley Wilson, Jared Henderson, Brooks Scull, Channabasavaiah Gurumurthy, Francisco Vega, Amy Chadburn, Branko Cuglievan, Nader Kim El-Mallawany, Carl Allen, Christopher Mason, Ari Melnick, Michael R Green

Faculty, Staff and Student Publications

SMARCA4 encodes one of two mutually exclusive ATPase subunits in the BRG/BRM associated factor (BAF) complex that is recruited by transcription factors (TFs) to drive chromatin accessibility and transcriptional activation. SMARCA4 is among the most recurrently mutated genes in human cancer, including ∼30% of germinal center (GC)-derived Burkitt lymphomas. In mice, GC-specific Smarca4 haploinsufficiency cooperated with MYC over-expression to drive lymphomagenesis. Furthermore, monoallelic Smarca4 deletion drove GC hyperplasia with centroblast polarization via significantly increased rates of centrocyte recycling to the dark zone. Mechanistically, Smarca4 loss reduced the activity of TFs that are activated in centrocytes to drive GC-exit, including SPI1 …

Arterial Spin-Labeling And Dsc Perfusion Metrics Improve Agreement In Neuroradiologists' Clinical Interpretations Of Posttreatment High-Grade Glioma Surveillance Mr Imaging-An Institutional Experience, Ghiam Yamin, Eric Tranvinh, Bryan A Lanzman, Elizabeth Tong, Syed S Hashmi, Chirag B Patel, Michael Iv

Faculty, Staff and Student Publications

Background and purpose: MR perfusion has shown value in the evaluation of posttreatment high-grade gliomas, but few studies have shown its impact on the consistency and confidence of neuroradiologists' interpretation in routine clinical practice. We evaluated the impact of adding MR perfusion metrics to conventional contrast-enhanced MR imaging in posttreatment high-grade glioma surveillance imaging.

Materials and methods: This retrospective study included 45 adults with high-grade gliomas who had posttreatment perfusion MR imaging. Four neuroradiologists assigned Brain Tumor Reporting and Data System scores for each examination on the basis of the interpretation of contrast-enhanced MR imaging and then after the addition …

Single-Cell Systems Pharmacology Identifies Development-Driven Drug Response And Combination Therapy In B Cell Acute Lymphoblastic Leukemia, Xin Huang, Yizhen Li, Jingliao Zhang, Lei Yan, Huanbin Zhao, Liang Ding, Sheetal Bhatara, Xu Yang, Satoshi Yoshimura, Wenjian Yang, Seth E Karol, Hiroto Inaba, Charles Mullighan, Mark Litzow, Xiaofan Zhu, Yingchi Zhang, Wendy Stock, Nitin Jain, Elias Jabbour, Steven M Kornblau, Marina Konopleva, Ching-Hon Pui, Elisabeth Paietta, William Evans, Jiyang Yu, Jun J Yang

Faculty, Staff and Student Publications

Leukemia can arise at various stages of the hematopoietic differentiation hierarchy, but the impact of developmental arrest on drug sensitivity is unclear. Applying network-based analyses to single-cell transcriptomes of human B cells, we define genome-wide signaling circuitry for each B cell differentiation stage. Using this reference, we comprehensively map the developmental states of B cell acute lymphoblastic leukemia (B-ALL), revealing its strong correlation with sensitivity to asparaginase, a commonly used chemotherapeutic agent. Single-cell multi-omics analyses of primary B-ALL blasts reveal marked intra-leukemia heterogeneity in asparaginase response: resistance is linked to pre-pro-B-like cells, with sensitivity associated with the pro-B-like population. By …

A Structured Curriculum Supporting Biomedical Trainees’ Transition Into Independent Academic Positions And Early Career Success, Mabel Perez-Oquendo, Gabriele Romano, David P Farris, Varsha Gandhi, Ignacio I Wistuba, Robert E Tillman, Ryan Udan, Paolo Mangahas, Rama Soundararajan

Faculty, Staff and Student Publications

The United States government makes a substantial investment in biomedical training programs each year. However, for most trainees, these opportunities do not translate into career progression in academic research pathways. Only about one-fifth of postdoctoral fellows eventually secure a tenure-track faculty position, and even among these candidates, attrition is high. Although a number of factors govern career choices and career longevity, the transition from trainee to faculty is a challenging process and requires knowledge and skills that are not necessarily developed during a traditional university experience. Many postdoctoral fellows receive adequate training in research skills and scientific communication, but new …

Lanthorn, Vol. 58, No. 16, April 8, 2024, Grand Valley State University

Volume 58, August 7, 2023 - April 15, 2024

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Narrative Language Assessment And Intervention: Applications With Children With And Without Disabilities, Norah M. Almubark

USF Tampa Graduate Theses and Dissertations

Narrative is the art of conveying a sequence of causally and temporally linked events through monologic telling. Various functions can be served through narratives including sharing experiences, expressing ideas, providing entertainment, and imparting cultural or social values. Narrative language represents an authentic type of language that is useful for assessment and intervention because it can be analyzed according to content and form. The ability to use complex narrative language and produce quality narratives is associated with long-term academic and social benefits (Uccelli et al., 2019; Suggate et al, 2018). Given this crucial link, narrative language is suitable for child language …

Investigating Which Muscles Are Most Responsible For Tremor Through Both Experimental Data And Simulation, Daniel Benjamin Free

Theses and Dissertations

Tremor affects millions of people and many patients desire alternative treatment options to medication or neural surgery. Peripheral suppression techniques are gaining greater use, but are currently applied in a trial-and-error method. To optimize these techniques, the muscles most responsible for an individual patient's tremor need to be identified. In this dissertation, I explored two parallel paths that both could aid in identifying muscles responsible for tremor. The first method utilizies measured data and a technique (coherence) that quantifies the frequency dependent correlation between two signals. Using coherence to identify muscles contributing to tremor requires at least two parts: an …

Making Way: A Methods Experiment With Arts-Based Embodied Postformal Autoethnography To Prepare For Research-As-Community Building With A Diverse Urban Elementary School, Kelly Elizabeth Bare

Theses & Dissertations

Using autoethnographic, arts-based, and embodied methods, this postformal dissertation study establishes the first of a two-part research-as-community-building template designed with racially and socioeconomically diverse school communities in mind. Imagined as a double helix in an echo of human DNA, it describes an arts-based, embodied self-study (Helix 1) as a prerequisite for later study of community (Helix 2, not yet complete) typified by mindful engagement across socially constructed lines of difference and attention to the potential building blocks of collaborative leadership across those same lines. As a prerequisite to community work, I explored my lifetime encounters with others of difference (Chang, …

Improving Breastfeeding Outcomes: A Pilot Randomized Controlled Trial Of A Self-Efficacy Intervention With Primiparous Mothers, Karen A. Mcqueen

Dissertations

Breastfeeding is recommended as the optimal source of nutrition for newborns for the first 6 months of life and beyond with the addition of complementary foods. While breastfeeding initiation rates have been increasing, duration rates remain a concern as many women prematurely discontinue due to difficulties encountered rather than maternal choice. In addition, there is a sizable gap between rates of exclusive breastfeeding and current recommendations. Targeting modifiable variables that may be amenable to intervention is one strategy to improve breastfeeding outcomes. One such modifiable variable is breastfeeding self-efficacy. Although research has clearly shown that breastfeeding self-efficacy is predictive of …

Examination Of Greenhouse Conditions That Influence Scale Infestation Rates On Begonia, Madeline M. Cusick

Honors College Theses

Scale insects are common pests within greenhouse and agricultural settings. I quantified scale infestation on Begonia x Richmondensis, also known as the Dragon Wing begonia, within the Armstrong Campus Greenhouse from March to November of 2023. Six different treatments accounted for variations in sunlight, humidity, and temperature within the greenhouse with the goal of determining the insect’s preferred environmental conditions. Morphological comparisons were also made between host plant Dragon Wing begonia and other begonias present within the greenhouse. Analysis indicated a significant difference in scale presence on replicate plants by zone and sunlight treatments, with more plants hosting at least …

Effects Of Time-Restricted Eating Patterns On Cardiometabolic Parameters And Mental Health Status In Young Adults., Mohammad Aleef Mohd Bakri

Student Works (2020-2029)

Cardiometabolic diseases, such as obesity, dyslipidemia, hypertension, and cardiovascular disease, along with mental health disorders like depression and anxiety, are closely linked to disruptions in circadian rhythm. Time-restricted eating (TRE) is an eating pattern that aligns with the circadian rhythm by restricting food intake to an 8–12-hour eating window during the daytime. Ramadan fasting, a form of TRE characterized by a nighttime eating window from dusk to dawn, offers a unique perspective as it contrasts with the typical diurnal eating pattern. However, no studies have directly compared TRE protocols with diurnal (daytime) and nocturnal (nighttime) eating windows within a single …

Imagery Training For Athletes With Low Imagery Abilities, Jonathan Rhodes, Karol Nedza, Jon May, Lucie Clements

School of Psychology

Imagery training, specifically visual and kinesthetic imagery training, is a well-established method of increasing performance in sport. However, some athletes may have impoverished imagery abilities (e.g., aphantasia; low visual imagery) which may hinder performance increments that benefit others. We administered the Plymouth Sensory Imagery Questionnaire (Psi-Q) which tests multisensory imagery, to 329 participants from nine different sports across two levels: semiprofessional and professional. This formed the baseline test, finding no significant differences between sport or level for imagery ability. The Psi-Q located 27 low imagers (mean total scores <4.2/10), including seven non-visual imagers, three non-auditory, seven non-olfactory, and five non-gustatory imagers, and one across all senses. We split the sample randomly into two groups and immediately delivered the imagery intervention, Functional Imagery Training (FIT) to the first group (over two weeks), followed by delivering the same intervention to the wait group. A wait period was due to the lengthy delivery time of the personalized intervention. Both groups received the intervention for the same duration ending in a Psi-Q retest after the intervention. In both groups, FIT increased overall imagery scores which was maintained six months after intervention completion. This indicates that imagery can be trained and maintained in those with a low ability. Follow up interviews (n = 22) explored how imagery was being used beyond the intervention, revealing that the majority now use imagery to plan and manage thinking. Recommendations are given for ways to train imagery in an applied sport setting and future research in broader areas is detailed. Lay summary: We identified 27 individuals with low multi-sensory imagery scores, and used Functional Imagery Training (FIT) to produce enduring improvements in imagery ability, positioning FIT as a valuable tool for enhancing cognitive skills in sports.

A Naturalistic Evaluation Of Mindfulness Training And Practice As Self-Care Resources For International Graduate Students In High-Stress Fields, Julie Laveglia

Electronic Theses and Dissertations Archive

Drawing on Social Constructionism (Berger & Luckmann, 1966; Gergen, 2009), this naturalistic evaluation (Guba, 1987; Lincoln & Guba, 1985) describes the effectiveness of mindfulness training and practice as self-care resources for international graduate students in the high-stress field of healthcare. The purpose of the study was to examine and understand the experiences of international graduate students trained in Mindfulness-Based Stress Reduction (MBSR) and analyze the ways that the training and practice shaped the wellbeing of the students. This evaluation also helped me, the administrator responsible for student affairs for this group of students, to better understand how they used the …

Nursing Professionals' Attitudes That May Impact Diagnostic Outcomes Among Patients With Disabilities, Louvisia Conley

Electronic Theses and Dissertations Archive

People with disabilities have been identified as representing the largest marginalized group worldwide. A negative attitude towards people with disabilities has been an extended paradigm in American society. Improving the treatment of people with disabilities has led to national policy and legislation changes. However, health inequities continue to be a significant issue faced by people with disabilities. Bourdieu's Theory of Practice provided the theoretical basis for this research. Using the Scale of Attitudes Toward Disabled Persons survey, this quantitative descriptive research aimed to examine factors that may impact attitudinal barriers among three groups, graduate nursing students, current practicing nurses, and …

Sickle Cell Disease In The State Of Tennessee, Ayesha Mukhopadhyay

Electronic Theses and Dissertations Archive

Sickle cell disease (SCD) is an inherited blood disorder. Normal red blood cells are round. In those with SCD, the red blood cells are crescent shaped. In the Unites States (US), more than 90% of those living with SCD are Black. We conducted three epidemiological studies related to the burden of common comorbidities in individuals with SCD, the relationship between SCD and chronic kidney disease, and the effects of historical racial housing policies on births with SCD. First, we evaluated the annual incidence and demographic associations of stroke, seizures, congestive heart failure, asthma, systemic hypertension, and diabetes mellitus in individuals …

Relationship Between Emotional Intelligence And Transition Shock In First-Semester Nursing Students, Christina Hillhouse

Electronic Theses and Dissertations Archive

Nursing student attrition rates contribute to the current nursing staff shortages in the United States. With many nursing students leaving their program after the first semester, identifying potential causes and interventions to mitigate these causes is a priority. Students report uncertainty and anxiety, as well as the incongruence between expectations and reality of nursing programs which can lead to transition shock. By assessing the ability of the students to understand, use, and manage their emotions, educators may be able to plan interventions to increase student retention. A quantitative correlational study assessed students in the first-semester Health Assessment course using the …

Rhetorics Of Impurities: Exvangelicalism As Excavating And Encountering Purity, Karly Poyner-Smith

Electronic Theses and Dissertations Archive

This dissertation explores purity discourse through the lens of the ExVangelical movement. Using mixed methods, this inquiry employs critical qualitative research to examine how ExVangelicalism uses the roles of identification, place, and space to critique purity’s oppressive categorizations. In doing so, ExVangelicals represent a theoretical rhetoric of impurities in which purity is continuously excavated and encountered. Based on a queer feminist reading of ExVangelical texts, this dissertation presents three frameworks in which to reorient ExVangelicalism as a post-purity movement. First, through ExVangelicalism, purity is examined through rhetorics of identification, place, and space. Second, as a post-purity movement, ExVangelicals partake in …

Her Journey. Her Way. Understanding The Development Of Career Self-Efficacy Through The Connect Mentoring Program For Women Faculty In Stem: A Case Study, Teresa Marion Theiling

Electronic Theses and Dissertations Archive

The Connect STEM Mentoring Program aims to provide professional and career connections to women in STEM. As a product of an ADVANCE grant funded by the National Science Foundation, this program strives to promote advancement for women in STEM. As a male- dominated field, women in STEM commonly face barriers to advancement opportunities which can negatively impact a woman’s career self-efficacy. This single-embedded case study seeks to understand how and why, if at all, the Connect STEM Mentoring Program develops career self- efficacy in career advancement for mid-level and senior-level female faculty members. The study investigates faculty members’ participation in …

Family Language Policy Of Transnational Returnees: The Case Of Arab Families Re-Adapting To Mainstream Arab Society, Alaa Alamri

Electronic Theses and Dissertations Archive

A significant body of research has delved into the dynamics of family language policy (FLP) within the context of transnational families. While much attention has been directed towards understanding the experiences of these families within the borders of their host countries, this study takes a unique perspective by investigating the construction and reconstruction of FLP as transnational families relocate within their home country. The aim of this dissertation is to examine the FLP of transnational families as they return to their homeland and endeavor to reintegrate into mainstream society (i.e., culturally, socially, and academically). The study employed a qualitative multiple …