Digital Commons Network^™

Harnessing Exosomes As A Platform For Drug Delivery In Breast Cancer: A Systematic Review For In Vivo And In Vitro Studies, Abdulwahab Teflischi Gharavi, Saeed Irian, Azadeh Niknejad, Keykavous Parang, Mona Salimi

Pharmacy Faculty Articles and Research

Breast cancer remains a significant global health concern, emphasizing the critical need for effective treatment strategies, especially targeted therapies. This systematic review summarizes the findings from in vitro and in vivo studies regarding the therapeutic potential of exosomes as drug delivery platforms in the field of breast cancer treatment. A comprehensive search was conducted across bibliographic datasets, including Web of Science, PubMed, and Scopus, using relevant queries from several related published articles and the Medical Subject Headings Database. Then, all morphological, biomechanical, histopathological, and cellular-molecular outcomes were systematically collected. A total of 30 studies were identified based on the Preferred …

J.R. Bronze Corp. V. Watson

All Decisions

In this holdover nuisance proceeding, the landlord failed to prove that the tenant's alleged unsanitary disposal of cat waste affected other tenants or the building. The court found no evidence of ongoing nuisance conduct and dismissed the case, underscoring the need for a consistent pattern of objectionable behavior to substantiate such claims.

Markale-Alsamod Sowell V. Altoona Police Department

2024 Decisions

USDC for the Western District of Pennsylvania

Implementing Teach Back Heart Failure Education To Improve Self-Care And Reduce Re-Hospitalization: A Quality Improvement Project, Sweata Patel

DNP Projects

Heart failure (HF) is a major health concern. External evidence supports the use of the teach-back method for patient education to promote self-care behaviors in patients with HF which may also reduce rehospitalizations. Patients with HF at one home health agency in New England participated in the quality improvement project which consisted of delivering 20 minute weekly standardized teach-back educational sessions covering topics of HF self-care over six weeks. The existing patient education materials and two new resources, Medication Tracker and Self-Check Plan for HF management, were reviewed. Three questions from the Self-Care of Heart Failure Index were asked during …

An Integrated Architecture For A Global Clean Energy Transition, Alice Kaswan

Journal of Interdisciplinary Perspectives and Scholarship

No abstract provided.

2024 April, 5-6; Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes; 2024 April, 5-6

2024 April, 5-6; Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes, 2024 April, 5-6

Resolution: SUNY Research Communication Enhancement

Load Reduction Leadership: A Cognitive Load Theory-Based Framework Differentiating Performance Patterns In Nyc Schools, Kristopher C. Bertoglio

Theses and Dissertations

This dissertation applies cognitive load theory to teacher working conditions in New York City. To connect small-scale cognitive processes with perennial organization-level effects, the theoretical components of this paper develop a novel framework. Load reduction leadership (LRL) illuminates how day-to-day school operations impact staff members’ cognition and school-level student performance. LRL extrapolates various cognitive load phenomena to schools’ complexities and time scales. Eight longitudinal case studies were found through New York State summative exam data. Schools were selected based on their abilities to over- and under-perform at improving their students’ proficiency, including schools that changed from under- to over-performance and …

April 5, 2024 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Ud In The News March 30-April 5, University Of Dayton

News Releases

UD eclipse committee member Jason Deibel was a guest of WDTN-TV's Five on 2 segment to discuss the history of eclipses in Ohio. Fox News, Inside Higher Ed, Business Insider and Catholic World Report featured faculty expertise.

Strategies For Addressing The Lack Of Skilled Workers In The Gig Economy, Joseph Charles Blanchard

Walden Dissertations and Doctoral Studies

No abstract provided.

Predictors Of Prep Uptake By Black Gay And Bisexual Men In Ohio, Ade Elisha

Walden Dissertations and Doctoral Studies

No abstract provided.

Flaxman, Judy, Laura Oldfather

Bronx Jewish History Project

Summarizer: Sophia Maier

Judy Flaxman’s family came to the Lower East Side from Eastern Europe in the early 1900s. As they grew more affluent, they moved to the Bronx, where Flaxman was born in 1948. She lived on Walton Avenue near Tremont Avenue, which she describes as very Jewish with some Catholics. She attended PS 28, Wade Junior High School, and Bronx Science. She played many outdoor games with friends from her community and did after school activities at the YM/WHA, through which she attended a day camp during the summers.

Flaxman’s mother was a secretary and her father, after …

Local Ecological Knowledge, Education, And Bilingualism: Ethnography Of A Stem Program For Elementary Students In Southwestern Florida, Barbara D. Herrera

USF Tampa Graduate Theses and Dissertations

In response to the limited inclusion of cultural relevant pedagogy in Science, Technology, Engineering, and Mathematics (STEM) centered educational programs, this study illustrates dynamics that encourage inclusivity and provide a space for minority students to develop self-efficacy while also exposing them to formal modes of STEM knowledge. Elementary level English/Spanish speaking children were taught local ecological knowledge (LEK) during a STEM summer program in a city in Southwestern Florida. The use of participant observation, group interviews with the students, and interviews with the educators allowed for an in-depth analysis of the program and the established goals. This study provides insight …

Csf Biomarkers Of Immune Activation And Alzheimer's Disease For Predicting Cognitive Impairment Risk In The Elderly, Francis Shue, Rachel Hendrix, Jason Ulrich, Rachel L Henson, William Knight, Chengjie Xiong, Jigyasha Timsina, Yun Ju Sung, Carlos Cruchaga, David M Holtzman, Et Al.

2020-Current year OA Pubs

The immune system substantially influences age-related cognitive decline and Alzheimer's disease (AD) progression, affected by genetic and environmental factors. In a Mayo Clinic Study of Aging cohort, we examined how risk factors like APOE genotype, age, and sex affect inflammatory molecules and AD biomarkers in cerebrospinal fluid (CSF). Among cognitively unimpaired individuals over 65 (

Subcellular Pathways Through Vglut3-Expressing Mouse Amacrine Cells Provide Locally Tuned Object-Motion-Selective Signals In The Retina, Karl Friedrichsen, Jen-Chun Hsiang, Chin-I Lin, Liam Mccoy, Katia Valkova, Daniel Kerschensteiner, Josh L Morgan

2020-Current year OA Pubs

VGluT3-expressing mouse retinal amacrine cells (VG3s) respond to small-object motion and connect to multiple types of bipolar cells (inputs) and retinal ganglion cells (RGCs, outputs). Because these input and output connections are intermixed on the same dendrites, making sense of VG3 circuitry requires comparing the distribution of synapses across their arbors to the subcellular flow of signals. Here, we combine subcellular calcium imaging and electron microscopic connectomic reconstruction to analyze how VG3s integrate and transmit visual information. VG3s receive inputs from all nearby bipolar cell types but exhibit a strong preference for the fast type 3a bipolar cells. By comparing …

Blocking Senescence And Tolerogenic Function Of Dendritic Cells Induced By Γδ Treg Cells Enhances Tumor-Specific Immunity For Cancer Immunotherapy, Fusheng Si, Xia Liu, Yan Tao, Yuanqin Zhang, Feiya Ma, Eddy C Hsueh, Sidharth V Puram, Guangyong Peng

2020-Current year OA Pubs

BACKGROUND: Regulatory T (Treg) cells are a key component in maintaining the suppressive tumor microenvironment and immune suppression in different types of cancers. A precise understanding of the molecular mechanisms used by Treg cells for immune suppression is critical for the development of effective strategies for cancer immunotherapy.

METHODS: Senescence development and tolerogenic functions of dendritic cells (DCs) induced by breast cancer tumor-derived γδ Treg cells were fully characterized using real-time PCR, flow cytometry, western blot, and functional assays. Loss-of-function strategies with pharmacological inhibitor and/or neutralizing antibody were used to identify the potential molecule(s) and pathway(s) involved in DC senescence …

Multi-Faceted Approach To Educating Physicians About The Impacts Of Climate Change On Their Patients’ Health, Deborah Simpson, Anne Getzin, Kjersti Knox, Kari A. Schmidt Oliver, Victoria Gillet, Karen Hanus, Amina Maamouri, Nicole Heilman, Rita Mitchell, Yolanda Manson, Kristin Ouweneel, Kathryn Agard

Aurora GME

No abstract provided.

Population Health Pop-Spotting, Stephenie Quirke, Morgan Erickson, Catherine Degrandville, Glenda Sundberg, Christina Dukehart, Will Lehmann

Aurora GME

No abstract provided.

Design And Test Of Wpum Topography Monitor For Iqos, Rawah Azeez

Theses

With the emergence of diverse tobacco product forms, such as electronic cigarettes and heat-not-burn, the global user base has surged to an estimated 1.3 billion. In the United States, 28.3 million adults and 3.08 million middle and high school adolescents engage in tobacco product use. However, our understanding of the usage behaviors of these various products is lacking. Puff topography, which measures the inhalation patterns of tobacco products, provides a wealth of information, including puff flow rate, duration, volume, and more. This information is crucial in understanding the health effects of tobacco products and the influence of usage behavior on …

Supercook: Design Interactive Culinary Experiences With Ai Technology, Yize Peng

Theses

The project 'SuperCook' is a groundbreaking design project that explores the integration of AI with culinary apps. It aims to revolutionize the kitchen experience by connecting users to new and accessible culinary adventures through personalized recipe recommendations, real-time cooking guidance, and interactive meal planning. By leveraging AI technology, 'SuperCook' not only enhances user convenience and efficiency but also fosters a deeper engagement with cooking and promotes healthier eating habits. This thesis delves into the design process, user testing, and iterative improvements that culminated in a user-centered, intuitive, and visually appealing UI/UX solution for modern cooking enthusiasts. In designing 'SuperCook,' attention …

A Macrophage-Cell Model Of Hiv Latency Reveals The Unusual Importance Of The Bromodomain Axis, Javan K Kisaka, Daniel Rauch, Malachi Griffith, George B Kyei

2020-Current year OA Pubs

BACKGROUND: Although macrophages are now recognized as an essential part of the HIV latent reservoir, whether and how viral latency is established and reactivated in these cell types is poorly understood. To understand the fundamental mechanisms of viral latency in macrophages, there is an urgent need to develop latency models amenable to genetic manipulations and screening for appropriate latency-reversing agents (LRAs). Given that differentiated THP-1 cells resemble monocyte-derived macrophages in HIV replication mechanisms, we set out to establish a macrophage cell model for HIV latency using THP-1 cells.

METHODS: We created single-cell clones of THP-1 cells infected with a single …

Sheets Of Sehs, University Of Dayton. School Of Education And Health Sciences

School of Education and Health Sciences Blog Archive

Some of the Departments and Centers within SEHS are having a friendly "sheet" competition for One Day, One Dayton! We're asking you to vote for your favorite sheet.

Clemson University Board Of Trustees, Full Minutes, 2024 April 5, Clemson University Board Of Trustees

Minutes

No abstract provided.

Swiss Cheese Heart: A Tale Of Multiple Valve Perforations, Hussam Al Hennawi, Shayan I. Khan, Aamna Khan, Usama Sadiq, Sung-Hae Cho

Abington Jefferson Health Papers

Gerbode defect, an anomalous connection between the left ventricle and right atrium, is often congenital but can be acquired or iatrogenically formed. We present an exceedingly rare case of this defect associated with multiple valve perforation in an otherwise healthy patient with bicuspid aortic valve and endocarditis.

The Dearth Of Knowledge Of Health Insurance Literacy Within The United States, Katherine A. Conzet

Honors Thesis

This literature review and cross-comparison were conducted to combine resources that bring to light the lack of knowledge on health insurance, the impact of this low health insurance literacy (HIL), and the lack of research being done in this subject field. This thesis analyzes and compares different research that measures HIL levels and compares these findings. At the same time, this thesis presents the complex history of health insurance and how this understanding can contribute to lower population HIL and proposes different ways to accurately measure HIL. The purpose is to show the necessity for more research into the field …

The Effects Of Global Temperature Change On Radon Exposure In Permafrost Areas, Melaan Bender

LSU Master's Theses

Global temperature increase leads to thawing of permafrost that protects local populations from radiation exposure by blocking radon-222 migrating into dwellings. This study aims at assessing the effects of permafrost thawing on the concentrations of radon in indoor air. An approach is developed to predict the evolution of the ²²²Rn concentrations by various processes including radon exhalation from thawed soil. It is found that as frozen soil thaws, more radon can enter dwellings, increasing the concentration of ²²²Rn in indoor air and elevating radiation-induced health risks. This study provides useful insight that will enhance understanding of potential climate …

Spatial Mapping Of The Benthic Community And How It Is Used To Research Effects Of Dredging In Louisiana's Lake Borgne., Meghan Johnson

LSU Master's Theses

Benthic communities are vitally important for healthy aquatic ecosystems across Louisiana’s coast. Specifically in Lake Borgne, ecologically important species of fish like the Gulf Sturgeon (Acipenser oxyrinchus desotoi) rely on benthic macrofauna as their main food source. The purpose of this study was to determine the spatial landscape of biodiversity and abundance of the benthic macrofauna community in Lake Borgne. Environmental conditions played a key role in community structure during the study period (fall 2021 through summer 2023) with a major drought occurring in 2023. In 2023, the decline in the abundance of most benthic invertebrates and in …

Examination Of The Effects Of Ultraviolet Radiation On The Toxicity Of An Array Of Pesticides, Polyaromatic Hydrocarbons, And Pharmaceuticals Via In-Vitro Bioassays, Jessica R. Stephens

LSU Master's Theses

Chemicals are often released via anthropogenic means both intentionally and unintentionally into aquatic environments. The chemical fate of these compounds can vary greatly depending on numerous factors that can include but are not limited to salinity, pH, dissolved oxygen, and exposure to ultraviolet radiation. The goal of this study was to investigate the effect of UV radiation on the level of toxicity of different chemicals over time. Chemicals were selected based on previous studies of the toxicity of both parent and metabolites formed as a result of photolysis. Anthracene, phenanthrene, anthraquinone, dicloran, chlorothalonil, hydroxy chlorothalonil, benzobicyclon hydrolysate, and sertraline were …

Enhancement Of Soybean Growth And Disease Resistance Through Seed-Priming Strategy, Francisco Javier Valle

LSU Master's Theses

Disease pressure and other environmental stresses, especially increasing temperature and drought incidence, accompanied with global climatic change have presented hard challenges to Louisiana soybean producers. The objective of this study was to explore the efficacy of seed priming techniques as new alternatives to improve soybean crop protection to reduce the amount of yield losses caused by biotic and abiotic stresses. In this study, five chemicals were used as priming agents at different concentrations (0.1 mM, 1 mM, and 10 mM) to evaluate their effectiveness in enhancing disease tolerance and yield in soybeans. A seed priming procedure was developed by partially …