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Teaching Fairness In Preschool: Evaluating The Steps In An Anti-Bias Education, Sharon Carnahan, Courtney Trohn, Cora Burkley, Diane Terorde Doyle Jul 2024

Teaching Fairness In Preschool: Evaluating The Steps In An Anti-Bias Education, Sharon Carnahan, Courtney Trohn, Cora Burkley, Diane Terorde Doyle

Faculty Publications

How do young children learn how to talk about ethical concepts, such as fairness and equity? The current research assesses the effects of philosophy-based anti-bias lessons aimed at three to five -year-olds in a laboratory preschool and explores the relationship between socioemotional skills, language development, and understanding of ethical concepts. The constructivist curriculum was grounded in storybook lessons with corresponding activities. In a pre-post test design, we interviewed children before and after lessons in fairness education that included book reading, related games, and philosophical discussions. We found that children showed a significant increase in comprehension of equity related terms and …


Scaling Work-Based Learning: Quality Criteria For Continuous Improvement And Equity, Dania Ibrahim, Heather Penczak, Emily Won Jul 2024

Scaling Work-Based Learning: Quality Criteria For Continuous Improvement And Equity, Dania Ibrahim, Heather Penczak, Emily Won

Practitioner Toolkits and Resources

No abstract provided.


Quality Criteria For College And Career Pathways Implementation, Laura Monteagudo, Emily Rusca, Liam Lawson Jul 2024

Quality Criteria For College And Career Pathways Implementation, Laura Monteagudo, Emily Rusca, Liam Lawson

Practitioner Toolkits and Resources

No abstract provided.


Medial Patellofemoral Ligament Augmented With A Reinforced Bioinductive Implant Is Biomechanically Similar To The Native Medial Patellofemoral Ligament At Time Zero In A Cadaveric Model, Sean Mcmillan, Seth Sherman, Zachary Brown, Erik Brewer, Elizabeth Ford Jul 2024

Medial Patellofemoral Ligament Augmented With A Reinforced Bioinductive Implant Is Biomechanically Similar To The Native Medial Patellofemoral Ligament At Time Zero In A Cadaveric Model, Sean Mcmillan, Seth Sherman, Zachary Brown, Erik Brewer, Elizabeth Ford

Rowan-Virtua School of Translational Biomedical Engineering & Sciences Departmental Research

Purpose: To biomechanically compare primary medial patellofemoral ligament (MPFL) repair (MPFLr) augmented with a reinforced bioinductive implant (RBI) to the native MPFL ligament and a semitendinosus (semi-T) MPFL reconstruction (MPFLR) at time zero. Methods: Four fresh-frozen matched pair cadavers (8 knees) were used to biomechanically compare the native MPFL to augmented MPFLr (n = 4) and semi-T MPFLR (n = 4). The native MPFL (n = 8) was isolated, preserving the femoral and patellar attachments, and pulled to failure. The semi-T was harvested from 1 of the matched pairs and whipstitched, as was a 250-mm × 5-mm RBI. A standard …


Section V.B Producer Price Index, Bureau Of Labor Statistics Jul 2024

Section V.B Producer Price Index, Bureau Of Labor Statistics

Documentary Appendix to Table 1-B of Professor Thompson’s Book <em>The Trump v. Harris Voter’s Guide to Their Economic Debate</em> (2024)

No abstract provided.


Rorschach Profiles In Adolescents: Cluster Analytically Derived Subgroups Based On The Revised Comprehensive System-Variables, Roni Sugarman Jul 2024

Rorschach Profiles In Adolescents: Cluster Analytically Derived Subgroups Based On The Revised Comprehensive System-Variables, Roni Sugarman

ETD Collection

This study explored the development and creation of the most frequently occurring Rorschach configurations made up of the major decision-making Comprehensive System-Revised variables (The Constriction Index, The Perceptual Thinking Index (PTI), The Affective Difficulty Index (ADI), The Coping Vulnerability Index (CVI), and Difference Score (D Score)) in a sample of 3,100 adolescents in an inpatient setting. A cluster analysis, K-Means Partitioning procedure specifically, was utilized to attain empirically derived commonly occurring Rorschach profile types using the Constriction Index, PTI, ADI, CVI, and D-score as clustering variables. The cluster analysis identified a total of 249 profile types among the inpatient sample, …


Factors Influencing Bridge Inspection In Developing Countries, Challenges And Future Directions: A Systematic Literature Review, Tuba Arshad, Dr. Rully Andhika Karim, Ayomi Dita Rarasati Jul 2024

Factors Influencing Bridge Inspection In Developing Countries, Challenges And Future Directions: A Systematic Literature Review, Tuba Arshad, Dr. Rully Andhika Karim, Ayomi Dita Rarasati

Smart City

Bridges are very important to promote economic growth, mitigate poverty, and address persistent environmental issues. With the construction of new bridges, it is crucial to have an effective bridge inspection procedure. But most developing countries are still struggling in this field. This review examines common factors affecting bridge inspection in developing countries and their impact on bridge condition and performance while exploring strategies to improve those factors in developing countries in a systematic review. A total of 172 articles were identified through an explorative search of Direct Scopus, Google Scholar, and hand-search with limitations of the years 2013 to 2024. …


Psychedelic Experiences And Long-Term Spiritual Growth: A Systematic Review, William A. Schutt, Julie J. Exline, Kathleen C. Pait, Joshua A. Wilt Jul 2024

Psychedelic Experiences And Long-Term Spiritual Growth: A Systematic Review, William A. Schutt, Julie J. Exline, Kathleen C. Pait, Joshua A. Wilt

Faculty Scholarship

Psychedelic substances, which can occasion mystical experiences, are sometimes used for religious and spiritual reasons. Despite strong links between psychedelics and spirituality, no previous systematic review has investigated connections between psychedelics and indicators of long-term spiritual growth. Thus, 34 empirical studies were analyzed with 19,724 total participants from 32 independent samples. A variety of methodologies were used among the reviewed studies, and some studies included international samples. Results showed that psychedelics—especially classic psychedelics (e.g., psilocybin, LSD, and DMT)—have been studied more often in this context than other substances. Findings indicate that psychedelic use is linked with a variety of subjective …


High Overlap Of Fungi Across The Range Of Douglas-Fir, James A. Lutz, Joseph D. Birch Jul 2024

High Overlap Of Fungi Across The Range Of Douglas-Fir, James A. Lutz, Joseph D. Birch

Wildland Resources Faculty Publications

Results of research in forest health and forest futures in Utah


Describing Nursing Care Of Severely Obese Patients In Critical Access Hospitals Using Total Quality Management Theory: A Qualitative Study, Amy M. Blankenship Jul 2024

Describing Nursing Care Of Severely Obese Patients In Critical Access Hospitals Using Total Quality Management Theory: A Qualitative Study, Amy M. Blankenship

Dissertations

The purpose of this study was to explore nurses' perceptions and experiences regarding caring for severely obese patients and factors that affect quality care of these patients in Critical Access Hospitals (CAHS).


Looking To The Past And Abroad To Enhance U.S. Presidential Debates, Jacob W. Justice, Talya P. Slaw, John Koch Jul 2024

Looking To The Past And Abroad To Enhance U.S. Presidential Debates, Jacob W. Justice, Talya P. Slaw, John Koch

Studies in Debate and Oratory

Presidential debates are a valuable, but flawed, method of educating voters about policy issues and candidates. Growing dissatisfaction with presidential debates, and polling evidence suggesting they are failing to inform audiences, creates exigence to reconsider the format of future debates. In this essay, we propose modifications to the format of United States presidential debates, in the interest of facilitating greater clash and audience education. To improve U.S. presidential debates, we draw upon two sources of inspiration: the history of U.S. presidential debates and international experiences with political debates. We recommend exploration of new debate formats that include (1) a narrow …


Ergonomics And Musculoskeletal Disorders: An Evaluation Of Self-Assessment Using Surveys, Shannon L. Sherman Jul 2024

Ergonomics And Musculoskeletal Disorders: An Evaluation Of Self-Assessment Using Surveys, Shannon L. Sherman

Dental Hygiene ETDs

Musculoskeletal disorders, MSDs, are a serious issue many dental professionals experience. It is understood that improper ergonomics are a contributing factor to developing MSDs. Several factors can be implemented into a dental hygienist’s everyday routine to help decrease the risk of developing musculoskeletal disorders. The purpose of this study was to investigate how many practicing dental hygienists experience musculoskeletal pain from daily hygiene practice and how ergonomics contributes to their level of pain. The study also discovered through self-assessment, areas participating dental hygienists would be willing to improve on in their daily ergonomic practice to potentially help decrease or prevent …


Dental Hygiene Burnout In Clinical Practice From Covid-19; A Pilot Study Using Self-Reported Questionaire, Yvette Valladares Jul 2024

Dental Hygiene Burnout In Clinical Practice From Covid-19; A Pilot Study Using Self-Reported Questionaire, Yvette Valladares

Dental Hygiene ETDs

The purpose of this study was to determine if the Covid-19 pandemic had increased feelings of burnout in registered dental hygienists who were employed in clinical practice before and during 2020. A survey of registered dental hygienists in California was employed. Participants completed a modified Maslach Burnout Inventory, to evaluate emotional exhaustion (EE), depersonalization (DP), and personal accomplishment (PA). One open-ended question explored specific aspects of Covid-19 contributing to burnout. 162 surveys were completed and 139 met the inclusion criteria. Data analysis revealed that 40.29% reported high Emotional Exhaustion, 43.17% experienced low Depersonalization, and 85.61% reported high Personal Achievement. Lastly, …


Justin De La Cruz Martinez V. Ned Nakles Jul 2024

Justin De La Cruz Martinez V. Ned Nakles

2024 Decisions

USDC for the Western District of Pennsylvania


Jose Galarza-Alvarado V. Attorney General United States Of America Jul 2024

Jose Galarza-Alvarado V. Attorney General United States Of America

2024 Decisions

Agency


27-Hydroxycholesterol Acts On Estrogen Receptor Α Expressed By Pomc Neurons In The Arcuate Nucleus To Modulate Feeding Behavior, Hui Ye, Xiaohua Yang, Bing Feng, Pei Luo, Valeria C.Torres Irizarry, Leslie Carrillo-Sáenz, Meng Yu, Yongjie Yang, Benjamin P. Eappen, Marcos David Munoz, Nirali Patel, Sarah Schaul, Lucas Ibrahimi, Penghua Lai, Xinyue Qi, Yuliang Zhou, Maya Kota, Devin Dixit, Madeline Mun, Chong Wee Liew, Yuwei Jiang, Chunmei Wang, Yanlin He, Pingwen Xu Jul 2024

27-Hydroxycholesterol Acts On Estrogen Receptor Α Expressed By Pomc Neurons In The Arcuate Nucleus To Modulate Feeding Behavior, Hui Ye, Xiaohua Yang, Bing Feng, Pei Luo, Valeria C.Torres Irizarry, Leslie Carrillo-Sáenz, Meng Yu, Yongjie Yang, Benjamin P. Eappen, Marcos David Munoz, Nirali Patel, Sarah Schaul, Lucas Ibrahimi, Penghua Lai, Xinyue Qi, Yuliang Zhou, Maya Kota, Devin Dixit, Madeline Mun, Chong Wee Liew, Yuwei Jiang, Chunmei Wang, Yanlin He, Pingwen Xu

Division of Basic Science Faculty Publications

Oxysterols are metabolites of cholesterol that regulate cholesterol homeostasis. Among these, the most abundant oxysterol is 27-hydroxycholesterol (27HC), which can cross the blood-brain barrier. Because 27HC functions as an endogenous selective estrogen receptor modulator, we hypothesize that 27HC binds to the estrogen receptor α (ERα) in the brain to regulate energy balance. Supporting this view, we found that delivering 27HC to the brain reduced food intake and activated proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (POMCARH) in an ERα-dependent manner. In addition, we observed that inhibiting brain ERα, deleting ERα in POMC neurons, or chemogenetic inhibition of …


An International Multidisciplinary Consensus On Pediatric Metabolic Dysfunction-Associated Fatty Liver Disease, Le Zhang, Mortada El-Shabrawi, Louise A. Baur, Christopher D. Byrne, Giovanni Targher, Mohit Kehar, Gilda Porta, Way Seah Lee, Sander Lefere, Serap Turan, Anna Alisi, Ram Weiss, Maria Felicia Faienza, Ambika Ashraf, Shikha S. Sundaram, Anshu Srivastava, Ruth De Bruyne, Yunkoo Kang, Flora Bacopoulou, Yong Hai Zhou, Andy Darma, Monica Lupsor-Platon, Masahide Hamaguchi, Anoop Misra, Nahum Méndez-Sánchez, Nicholas Beng Hui Ng, Claude Marcus, Amanda E. Staiano, Nadia Waheed, Saleh A. Alqahtani, Cosimo Giannini, Ponsiano Ocama, Mindie H. Nguyen, Maria Teresa Arias-Loste Jul 2024

An International Multidisciplinary Consensus On Pediatric Metabolic Dysfunction-Associated Fatty Liver Disease, Le Zhang, Mortada El-Shabrawi, Louise A. Baur, Christopher D. Byrne, Giovanni Targher, Mohit Kehar, Gilda Porta, Way Seah Lee, Sander Lefere, Serap Turan, Anna Alisi, Ram Weiss, Maria Felicia Faienza, Ambika Ashraf, Shikha S. Sundaram, Anshu Srivastava, Ruth De Bruyne, Yunkoo Kang, Flora Bacopoulou, Yong Hai Zhou, Andy Darma, Monica Lupsor-Platon, Masahide Hamaguchi, Anoop Misra, Nahum Méndez-Sánchez, Nicholas Beng Hui Ng, Claude Marcus, Amanda E. Staiano, Nadia Waheed, Saleh A. Alqahtani, Cosimo Giannini, Ponsiano Ocama, Mindie H. Nguyen, Maria Teresa Arias-Loste

Population and Public Health Science Faculty Publications

Background: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in children and adolescents, particularly those with obesity. NAFLD is considered a hepatic manifestation of the metabolic syndrome due to its close associations with abdominal obesity, insulin resistance, and atherogenic dyslipidemia. Experts have proposed an alternative terminology, metabolic dysfunction-associated fatty liver disease (MAFLD), to better reflect its pathophysiology. This study aimed to develop consensus statements and recommendations for pediatric MAFLD through collaboration among international experts. Methods: A group of 65 experts from 35 countries and six continents, including pediatricians, hepatologists, and endocrinologists, participated in a consensus development process. The process encompassed …


Real-World Evidence Study On The Early Use Of Cemiplimab In The Uk: React-Cemi (Real World Evidence Of Advanced Cscc Treatment With Cemiplimab), Amarnath Challapalli, Grant Stewart, Heather Shaw, Peter John Davies, Juan Carlos Lopez-Baez, Edward C Ottley, Stephen Kelly Jul 2024

Real-World Evidence Study On The Early Use Of Cemiplimab In The Uk: React-Cemi (Real World Evidence Of Advanced Cscc Treatment With Cemiplimab), Amarnath Challapalli, Grant Stewart, Heather Shaw, Peter John Davies, Juan Carlos Lopez-Baez, Edward C Ottley, Stephen Kelly

Faculty, Staff and Student Publications

BACKGROUND: Cemiplimab was licensed in the United Kingdom (UK) in 2019 for the treatment of patients with locally advanced and metastatic CSCC not suitable for curative surgery or radiotherapy (advanced CSCC [aCSCC]). No UK multi-center studies have investigated the real-world experience of cemiplimab post marketing authorization in aCSCC.

METHODS: This non-interventional retrospective study (10 UK centers) involved data collection from medical records of patients with aCSCC who initiated cemiplimab treatment between 2 July 2019 and 30 November 2020. The study period was a minimum of 12 and a maximum of 36 months post cemiplimab initiation. The primary objective was to …


July 12, 2024 Ereporter, University Of Alabama At Birmingham Jul 2024

July 12, 2024 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Conditional Approval Letter For The 2024 Butte Priority Soils (Bpsou) Residential Metals Abatement Program (Rmap) – Quality Assurance Project Plan (Qapp) Annual Update (Non-Residential Parcels And Residential Daycares) (Dated July 1, 2024), Molly Roby Jul 2024

Conditional Approval Letter For The 2024 Butte Priority Soils (Bpsou) Residential Metals Abatement Program (Rmap) – Quality Assurance Project Plan (Qapp) Annual Update (Non-Residential Parcels And Residential Daycares) (Dated July 1, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


East African Refugee Women Seeking Health Care After Government Assistance Ends, Sylivia Chelimo Jul 2024

East African Refugee Women Seeking Health Care After Government Assistance Ends, Sylivia Chelimo

Walden Dissertations and Doctoral Studies

East African refugee women arrive as a vulnerable population in their host country. Before coming to the United States, refugee women may have experienced varying levels of trauma due to civil wars, genocide, sexual assault, deaths of loved ones, terrorist attacks, being taken hostage, and torture in their home country. The purpose of this generic qualitative study was to explore the experiences of refugee women from East African countries seeking health care in the Central United States when government assistance ends. The framework of the behavioral model of health was the guide for examining the experiences of the participant refugee …


School Counselors’ Perceptions And Descriptions Of Their Career Counseling Efforts For Non-Honor Roll Students In Career Management, Sherlette C. Burkhalter Jul 2024

School Counselors’ Perceptions And Descriptions Of Their Career Counseling Efforts For Non-Honor Roll Students In Career Management, Sherlette C. Burkhalter

Walden Dissertations and Doctoral Studies

High-quality career counseling is freely available at U.S. high schools. However, many students choose not to participate in career planning programs, despite being assigned to a school counselor for guidance. There is a projected increase in demand for school counselors; however, there needs to be more literature regarding whether high school students are taking advantage of career planning and how counselors cope with and manage their role in implementing career counseling programs. The purpose of this study was to explore school counselors’ perceptions and descriptions of their career counseling efforts for non-honor roll students in career management. The theoretical framework …


Utilizing The Health Belief Model To Evaluate Barriers To Screening Black Women For Perinatal Depression, Rasheed Davis Jul 2024

Utilizing The Health Belief Model To Evaluate Barriers To Screening Black Women For Perinatal Depression, Rasheed Davis

Walden Dissertations and Doctoral Studies

Perinatal depression is an important public health issue that disproportionately affects Black women and contributes to negative maternal and birth outcomes. This quantitative, correlational cross-sectional study aimed to understand the relationship between health care providers’ likelihood of screening for perinatal depression among Black women and their perceptions framed within the health belief model. This study was conducted to examine the impact of health care providers’ perceived susceptibility, perceived severity, perceived benefits, and perceived self-efficacy on the likelihood of screening for perinatal depression. This study was conducted in New York state and included 92 health care providers who actively provide prenatal …


The Impact Of Liberia’S Post-War Public Housing Policy On Homelessness, Bofor Rahim Toh, Ii Jul 2024

The Impact Of Liberia’S Post-War Public Housing Policy On Homelessness, Bofor Rahim Toh, Ii

Walden Dissertations and Doctoral Studies

There is an inadequacy in strategies to address homeless and vulnerable youth “Zogos” in post-war Liberia. Homelessness among youth is a severe problem in post-war Liberia, with many sleeping in Palm Groove Cemetery and other informal housing settings in Monrovia and other parts of the country. This qualitative study explored post-war Liberia’s public housing program policy roles that professional competency and human capacity play in effectively mitigating homelessness of youth in Monrovia. Glasser’s choice theory was the theoretical framework used for this study. The research question explored how human capacity, selection eligibility, and professional competency at the National Housing Authority …


Experiences Of Black Males With Generalized Anxiety Disorder During The Covid-19 Pandemic, Cynthia Lynn Williams Jul 2024

Experiences Of Black Males With Generalized Anxiety Disorder During The Covid-19 Pandemic, Cynthia Lynn Williams

Walden Dissertations and Doctoral Studies

This qualitative research dissertation involved exploring the intersection of race, gender, and mental health via lived experiences of Black males who were diagnosed with generalized anxiety disorder during the COVID-19 pandemic to provide a comprehensive understanding of how the unique sociocultural context of the pandemic influenced their experiences with anxiety. Using a qualitative Interpretive Phenomenological Analysis research design and semi-structured interviews with a diverse sample of seven Black males living in various regions of the United States the interviews involved their personal experiences, coping mechanisms, and perceptions of societal and systemic factors that affected their mental health during the pandemic. …


Carbonate And Organic Proxies And The Impacts Of Climate On Lake Systems: Paleoclimate Interpretations From Lake Chalco, Mexico, Aria Holmes Jul 2024

Carbonate And Organic Proxies And The Impacts Of Climate On Lake Systems: Paleoclimate Interpretations From Lake Chalco, Mexico, Aria Holmes

Earth and Planetary Sciences ETDs

This project incorporates several lines of evidence to better understand the climate at Lake Chalco. Chapter 1 utilizes oxygen isotopes from carbonates and show that the Inter Tropical Convergence Zone varies on primarily glacial and millennial timescales; precession is not observed. These data indicate glacials periods were shallower and interglacials were wetter periods at Lake Chalco. Chapter 2 studies carbon, nitrogen, C/N, and TOC proxies and finds that the lake conditions during the glacials and interglacials are primarily a mixed algal-macrophyte-terrestrial organic matter. Deviations show that the lake during the interglacials had more algal organic matter- reflecting influxes of nutrients …


Genetic And Multi-Omic Resources For Alzheimer Disease And Related Dementia From The Knight Alzheimer Disease Research Center, Maria Victoria Fernandez, Menghan Liu, Aleksandra Beric, Matt Johnson, Arda Cetin, Maulik Patel, John Budde, Pat Kohlfeld, Kristy Bergmann, Joseph Lowery, Allison Flynn, William Brock, Brenda Sanchez Montejo, Jen Gentsch, Nicholas Sykora, Joanne Norton, Jen Gentsch, Olga Valdez, Priyanka Gorijala, Jessie Sanford, Yichen Sun, Ciyang Wang, Dan Western, Jigyasha Timsina, Tassia Mangetti Goncalves, Anh N Do, Yun Ju Sung, Guoyan Zhao, John C Morris, Krista Moulder, David M Holtzman, Randall J Bateman, Celeste Karch, Jason Hassenstab, Chengjie Xiong, Suzanne E Schindler, Joyce Joy Balls-Berry, Tammie L S Benzinger, Richard J Perrin, Andrea Denny, B Joy Snider, Susan L Stark, Laura Ibanez, Carlos Cruchaga Jul 2024

Genetic And Multi-Omic Resources For Alzheimer Disease And Related Dementia From The Knight Alzheimer Disease Research Center, Maria Victoria Fernandez, Menghan Liu, Aleksandra Beric, Matt Johnson, Arda Cetin, Maulik Patel, John Budde, Pat Kohlfeld, Kristy Bergmann, Joseph Lowery, Allison Flynn, William Brock, Brenda Sanchez Montejo, Jen Gentsch, Nicholas Sykora, Joanne Norton, Jen Gentsch, Olga Valdez, Priyanka Gorijala, Jessie Sanford, Yichen Sun, Ciyang Wang, Dan Western, Jigyasha Timsina, Tassia Mangetti Goncalves, Anh N Do, Yun Ju Sung, Guoyan Zhao, John C Morris, Krista Moulder, David M Holtzman, Randall J Bateman, Celeste Karch, Jason Hassenstab, Chengjie Xiong, Suzanne E Schindler, Joyce Joy Balls-Berry, Tammie L S Benzinger, Richard J Perrin, Andrea Denny, B Joy Snider, Susan L Stark, Laura Ibanez, Carlos Cruchaga

2020-Current year OA Pubs

The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, and molecular understanding of Alzheimer Disease. Over more than 40 years, research volunteers have been recruited to participate in cognitive, neuropsychologic, imaging, fluid biomarkers, genomic and multi-omic studies. Tissue and longitudinal data collected to foster, facilitate, and support research on dementia and aging. The Genetics and high throughput -omics core (GHTO) have collected of more than 26,000 biological samples from 6,625 Knight-ADRC participants. Samples available include longitudinal DNA, RNA, non-fasted plasma, cerebrospinal fluid pellets, …


Pulmonary Osteoclast-Like Cells In Silica Induced Pulmonary Fibrosis, Yoshihiro Hasegawa, Steven L Teitelbaum, Et Al. Jul 2024

Pulmonary Osteoclast-Like Cells In Silica Induced Pulmonary Fibrosis, Yoshihiro Hasegawa, Steven L Teitelbaum, Et Al.

2020-Current year OA Pubs

The pathophysiology of silicosis is poorly understood, limiting development of therapies for those who have been exposed to the respirable particle. We explored mechanisms of silica-induced pulmonary fibrosis in human lung samples collected from patients with occupational exposure to silica and in a longitudinal mouse model of silicosis using multiple modalities including whole-lung single-cell RNA sequencing and histological, biochemical, and physiologic assessments. In addition to pulmonary inflammation and fibrosis, intratracheal silica challenge induced osteoclast-like differentiation of alveolar macrophages and recruited monocytes, driven by induction of the osteoclastogenic cytokine, receptor activator of nuclear factor κΒ ligand (RANKL) in pulmonary lymphocytes, and …


Thermodynamic Coupling Of The Tandem Rrm Domains Of Hnrnp A1 Underlie Its Pleiotropic Rna Binding Functions, Jeffrey D Levengood, Davit Potoyan, Srinivasa Penumutchu, Abhishek Kumar, Qianzi Zhou, Yiqing Wang, Alexandar L Hansen, Sebla Kutluay, Julien Roche, Blanton S Tolbert Jul 2024

Thermodynamic Coupling Of The Tandem Rrm Domains Of Hnrnp A1 Underlie Its Pleiotropic Rna Binding Functions, Jeffrey D Levengood, Davit Potoyan, Srinivasa Penumutchu, Abhishek Kumar, Qianzi Zhou, Yiqing Wang, Alexandar L Hansen, Sebla Kutluay, Julien Roche, Blanton S Tolbert

2020-Current year OA Pubs

The functional properties of RNA binding proteins (RBPs) require allosteric regulation through interdomain communication. Despite the importance of allostery to biological regulation, only a few studies have been conducted to describe the biophysical nature by which interdomain communication manifests in RBPs. Here, we show for hnRNP A1 that interdomain communication is vital for the unique stability of its amino-terminal domain, which consists of two RNA recognition motifs (RRMs). These RRMs exhibit drastically different stability under pressure. RRM2 unfolds as an individual domain but remains stable when appended to RRM1. Variants that disrupt interdomain communication between the tandem RRMs show a …


Domestic Violence Primary Prevention: Evidence From The Past Decade, Ingrid Johnson Jul 2024

Domestic Violence Primary Prevention: Evidence From The Past Decade, Ingrid Johnson

AJiC Fact Sheets

This fact sheet summarizes findings from 16 meta-analyses synthesizing the results of evaluations of primary domestic violence prevention interventions between 2014 and 2024. Primary prevention includes policies or programs that stop the onset of crime perpetration and/or victimization. Domestic violence includes sexual violence, stalking, physical violence, psychological aggression, and/or control of reproductive or sexual health by spouses, boy or girlfriends, dating partners, or hook up partners. Findings show a preventative effect amongst youth and community-based adults, while no preventative effect was seen in college students.