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Chronic Eosinophilic Leukemia With A Novel Jak1 Mutation Responds Well To The Jak1/2 Inhibitor Ruxolitinib, Qing Wei, Jie Xu

Faculty, Staff and Student Publications

No abstract provided.

A Staff Education Project For Administration Of Phq-9 To Adult Patients In The Emergency Department, Jessica Leigh Ionno

Walden Dissertations and Doctoral Studies

Depression is a global healthcare crisis impacting millions worldwide. In the United States, over 8% of adults experience depression, leading to significant disability and increased healthcare costs. Many individuals with depression seek initial treatment in emergency departments (EDs). This project aims to reduce the burden of depression by training ED nurses to identify at-risk patients early and provide timely interventions and referrals. Benefits include improved patient outcomes, decreased healthcare costs, and social change to address the mental health crisis. Utilizing Malcolm Knowles’ adult learning theory, the project emphasizes collaborative learning relevant to the clinical setting. The partner site is a …

Emerging Biomedical And Clinical Applications Of 3d-Printed Poly(Lactic Acid)-Based Devices And Delivery Systems, Allan John R Barcena, Prashanth Ravi, Suprateek Kundu, Karthik Tappa

Faculty, Staff and Student Publications

Poly(lactic acid) (PLA) is widely used in the field of medicine due to its biocompatibility, versatility, and cost-effectiveness. Three-dimensional (3D) printing or the systematic deposition of PLA in layers has enabled the fabrication of customized scaffolds for various biomedical and clinical applications. In tissue engineering and regenerative medicine, 3D-printed PLA has been mostly used to generate bone tissue scaffolds, typically in combination with different polymers and ceramics. PLA's versatility has also allowed the development of drug-eluting constructs for the controlled release of various agents, such as antibiotics, antivirals, anti-hypertensives, chemotherapeutics, hormones, and vitamins. Additionally, 3D-printed PLA has recently been used …

A Crisis In Clinical Research, David S Hong, Patricia Lorusso, Mario Sznol

Faculty, Staff and Student Publications

The clinical research pipeline is critical to ensuring continued development of novel treatments that can offer patients with cancer safe and effective options. Unfortunately, progress has slowed since the COVID-19 pandemic due to uncovered, systemic inefficiencies across critical processes. Towards initiating discussion on how to reinvigorate clinical research, the Society for Immunotherapy of Cancer (SITC) hosted a virtual summit that characterized issues and formed potential solutions. This commentary serves to highlight the crisis facing clinical research as well as stimulate field-wide discussion on how to better serve patients into the future.

Using Triangulation And Crystallization To Make Qualitative Studies Trustworthy And Rigorous, Hani Morgan

The Qualitative Report

Qualitative research is often criticized for lacking rigor and consisting of opinions that result from researcher bias. But like well-designed quantitative research, qualitative studies can be trustworthy. Qualitative researchers generally agree that some practices, such as triangulation, can be used to increase the credibility of the kind of research they conduct. Unfortunately, many researchers are confused about or unaware of the different types of triangulation strategies, leading them to write papers without accurately identifying which ones they used. Triangulation is also a contested approach for many qualitative researchers because it is oftentimes associated with a post-positivist paradigm. Unlike quantitative researchers, …

Compassionate Care In Elementary General Music Teaching And Learning As A Way To Respond To The World: A Narrative Inquiry, Julia K. Church Hoffman

Teacher Education, Educational Leadership & Policy ETDs

In this narrative inquiry, where stories were the data, three experienced music teachers from one public school district in the southwestern United States shared stories about their experiences as elementary general music teachers. The stories were told through the lens of compassionate care, a perspective that implies a shared experience between teacher and learners (Hendricks, 2018, 2023). The stories, and my interpretation of them, revealed an understanding of elementary general music, a multimodal, fun, school subject, as a vehicle for teaching children how to be kind and respectful humans. Threads that emerged from the stories linked connections between compassionate care, …

The Impact Of Clinical Genome Sequencing In A Global Population With Suspected Rare Genetic Disease, Arturo Serize, Jorge Perez

All Publications

There is mounting evidence of the value of clinical genome sequencing (cGS) in individuals with suspected rare genetic disease (RGD), but cGS performance and impact on clinical care in a diverse population drawn from both high-income countries (HICs) and low- and middle-income countries (LMICs) has not been investigated. The iHope program, a philanthropic cGS initiative, established a network of 24 clinical sites in eight countries through which it provided cGS to individuals with signs or symptoms of an RGD and constrained access to molecular testing. A total of 1,004 individuals (median age, 6.5 years; 53.5% male) with diverse ancestral backgrounds …

Case Report: Intrafraction Dose-Guided Tracking For Gastrointestinal Organ-At-Risk Isotoxicity Delivery On An Mr-Guided Radiotherapy System, Sreenija Yarlagadda, Yonatan Weiss, Michael Chuong, Nema Bassiri Gharb, Alonso Gutierrez, Rupesh Kotecha, Minesh Mehta, Kathryn Mittauer

All Publications

In the current era of high-precision radiation therapy, real-time magnetic resonance (MR)-guided tracking of the tumor and organs at risk (OARs) is a novel approach that enables accurate and safe delivery of high-dose radiation. Organ tracking provides a general sense of the need for daily online adaptation but lacks precise information regarding exact dosimetry. To overcome this limitation, we developed the methodology for monitoring intrafraction motion with real-time MR-guided isodose line-based tracking of an OAR in combination with anatomic tumor-based tracking and reported the first case treated with this approach. An isolated para-aortic (PA) nodal recurrence from carcinosarcoma of the …

Reflections On The Past, Present, And Potential Futures Of Knowledge Hierarchies In Ocean Biodiversity Governance Research, Holly J. Niner, David Wilson, Kelly Hoareau, Mia Strand, Jennifer Whittingham, Dylan Mcgarry, Bolanle Erinosho, Sulley Ibrahim, Sirkka Tshiningayamwe, Senia Febrica, Alana Malinde S. N. Lancaster, Milica Prokic

School of Biological and Marine Sciences

Governance of the ocean and its biodiversity is deeply entangled within social, political and cultural histories. The evolution of marine science has been subject to similar influences, and we (the authors) consider these factors to create, embed and reinforce knowledge hierarchies in ocean governance processes and associated research that set societal patterns of prioritisation and exclusion. Such knowledge hierarchies have constructed dominant Western-oriented knowledge systems as ‘rational’ and ‘objective’ approaches to environmental governance in contrast to non-Western knowledge systems and have led to a dominance of natural (normal) sciences over centralised biodiversity governance. The extraction and incorporation of traditional knowledge …

Clonal Hematopoiesis Driven By Mutated Dnmt3a Promotes Inflammatory Bone Loss, Hui Wang, Kimon Divaris, Bohu Pan, Xiaofei Li, Jong-Hyung Lim, Gundappa Saha, Marko Barovic, Danai Giannakou, Jonathan M Korostoff, Yu Bing, Souvik Sen, Kevin Moss, Di Wu, James D Beck, Christie M Ballantyne, Pradeep Natarajan, Kari E North, Mihai G Netea, Triantafyllos Chavakis, George Hajishengallis

Faculty, Staff and Student Publications

Clonal hematopoiesis of indeterminate potential (CHIP) arises from aging-associated acquired mutations in hematopoietic progenitors, which display clonal expansion and produce phenotypically altered leukocytes. We associated CHIP-DNMT3A mutations with a higher prevalence of periodontitis and gingival inflammation among 4,946 community-dwelling adults. To model DNMT3A-driven CHIP, we used mice with the heterozygous loss-of-function mutation R878H, equivalent to the human hotspot mutation R882H. Partial transplantation with Dnmt3a

Histopathology Imaging And Clinical Data Including Remission Status In Pediatric Inflammatory Bowel Disease, Chloe Martin-King, Ali Nael, Louis Ehwerhemuepha, Blake Calvo, Quinn Gates, Jamie Janchoi, Elisa Ornelas, Melissa Perez, Andrea Venderby, John Miklavcic, Peter Chang, Aaron Sassoon, Kenneth Grant

Food Science Faculty Articles and Research

The incidence of inflammatory bowel disease (IBD) is increasing annually. Children with IBD often suffer significant morbidity due to physical and emotional effects of the disease and treatment. Corticosteroids, often a component of therapy, carry undesirable side effects with long term use. Steroid-free remission has become a standard for care-quality improvement. Anticipating therapeutic outcomes is difficult, with treatments often leveraged in a trial-and-error fashion. Artificial intelligence (AI) has demonstrated success in medical imaging classification tasks. Predicting patients who will attain remission will help inform treatment decisions. The provided dataset comprises 951 tissue section scans (167 whole-slides) obtained from 18 pediatric …

Intrinsically Disordered Membrane Anchors Of Rheb, Rhoa, And Diras3 Small Gtpases: Molecular Dynamics, Membrane Organization, And Interactions, Chase M Hutchins, Alemayehu A Gorfe

Faculty, Staff and Student Publications

Protein structure has been well established to play a key role in determining function; however, intrinsically disordered proteins and regions (IDPs and IDRs) defy this paradigm. IDPs and IDRs exist as an ensemble of structures rather than a stable 3D structure yet play essential roles in many cell-signaling processes. Nearly all Ras superfamily GTPases are tethered to membranes by a lipid tail at the end of a flexible IDR. The sequence of the IDR is a key determinant of membrane localization, and interaction between the IDR and the membrane has been shown to affect signaling in RAS proteins through the …

Full-Length Αiibβ3 Cryo-Em Structure Reveals Intact Integrin Initiate-Activation Intrinsic Architecture, Tong Huo, Hongjiang Wu, Zeinab Moussa, Mehmet Sen, Valerie Dalton, Zhao Wang

Faculty, Staff and Students Publications

Integrin αIIbβ3 is the key receptor regulating platelet retraction and accumulation and a proven drug-target for antithrombotic therapies. Here we resolve the cryoEM structures of the full-length αIIbβ3, which covers three distinct states along the activation pathway. Firstly, we obtain the αIIbβ3 structure at 3Å resolution in the inactive state, revealing the overall topology of the heterodimer with the transmembrane (TM) helices and the ligand-binding domain tucked in a specific angle proximity to the TM region. After the addition of a Mn2+ agonist, we resolve two coexisting structures representing two new states between inactive and active state. Our structures show …

Msl2 Variants Lead To A Neurodevelopmental Syndrome With Lack Of Coordination, Epilepsy, Specific Dysmorphisms, And A Distinct Episignature, Remzi Karayol, Maria Carla Borroto, Sadegheh Haghshenas, Anoja Namasivayam, Jack Reilly, Michael A Levy, Raissa Relator, Jennifer Kerkhof, Haley Mcconkey, Maria Shvedunova, Andrea K Petersen, Kari Magnussen, Christiane Zweier, Georgia Vasileiou, André Reis, Juliann M Savatt, Meghan R Mulligan, Louise S Bicknell, Gemma Poke, Aya Abu-El-Haija, Jessica Duis, Vickie Hannig, Siddharth Srivastava, Elizabeth Barkoudah, Natalie S Hauser, Myrthe Van Den Born, Uri Hamiel, Noa Henig, Hagit Baris Feldman, Shane Mckee, Ingrid P C Krapels, Yunping Lei, Albena Todorova, Ralitsa Yordanova, Slavena Atemin, Mihael Rogac, Vivienne Mcconnell, Anna Chassevent, Kristin W Barañano, Vandana Shashi, Jennifer A Sullivan, Angela Peron, Maria Iascone, Maria P Canevini, Jennifer Friedman, Iris A Reyes, Janell Kierstein, Joseph J Shen, Faria N Ahmed, Xiao Mao, Berta Almoguera, Fiona Blanco-Kelly, Konrad Platzer, Ariana-Berenike Treu, Juliette Quilichini, Alexia Bourgois, Nicolas Chatron, Louis Januel, Christelle Rougeot, Deanna Alexis Carere, Kristin G Monaghan, Justine Rousseau, Kenneth A Myers, Bekim Sadikovic, Asifa Akhtar, Philippe M Campeau

Faculty, Staff and Students Publications

Epigenetic dysregulation has emerged as an important etiological mechanism of neurodevelopmental disorders (NDDs). Pathogenic variation in epigenetic regulators can impair deposition of histone post-translational modifications leading to aberrant spatiotemporal gene expression during neurodevelopment. The male-specific lethal (MSL) complex is a prominent multi-subunit epigenetic regulator of gene expression and is responsible for histone 4 lysine 16 acetylation (H4K16ac). Using exome sequencing, here we identify a cohort of 25 individuals with heterozygous de novo variants in MSL complex member MSL2. MSL2 variants were associated with NDD phenotypes including global developmental delay, intellectual disability, hypotonia, and motor issues such as coordination problems, feeding …

Psmd11 Loss-Of-Function Variants Correlate With A Neurobehavioral Phenotype, Obesity, And Increased Interferon Response, Wallid Deb, Cory Rosenfelt, Virginie Vignard, Jonas Johannes Papendorf, Sophie Möller, Martin Wendlandt, Maja Studencka-Turski, Benjamin Cogné, Thomas Besnard, Léa Ruffier, Bérénice Toutain, Léa Poirier, Silvestre Cuinat, Amy Kritzer, Amy Crunk, Janette Dimonda, Jaime Vengoechea, Sandra Mercier, Lotte Kleinendorst, Mieke M Van Haelst, Linda Zuurbier, Telma Sulem, Hildigunnur Katrínardóttir, Rún Friðriksdóttir, Patrick Sulem, Kari Stefansson, Berglind Jonsdottir, Shimriet Zeidler, Margje Sinnema, Alexander P A Stegmann, Natali Naveh, Cara M Skraban, Christopher Gray, Jill R Murrell, Sedat Isikay, Davut Pehlivan, Daniel G Calame, Jennifer E Posey, Mathilde Nizon, Kirsty Mcwalter, James R Lupski, Bertrand Isidor, François V Bolduc, Stéphane Bézieau, Elke Krüger, Sébastien Küry, Frédéric Ebstein

Faculty, Staff and Students Publications

Primary proteasomopathies have recently emerged as a new class of rare early-onset neurodevelopmental disorders (NDDs) caused by pathogenic variants in the PSMB1, PSMC1, PSMC3, or PSMD12 proteasome genes. Proteasomes are large multi-subunit protein complexes that maintain cellular protein homeostasis by clearing ubiquitin-tagged damaged, misfolded, or unnecessary proteins. In this study, we have identified PSMD11 as an additional proteasome gene in which pathogenic variation is associated with an NDD-causing proteasomopathy. PSMD11 loss-of-function variants caused early-onset syndromic intellectual disability and neurodevelopmental delay with recurrent obesity in 10 unrelated children. Our findings demonstrate that the cognitive impairment observed in these individuals could be …

Correction: Type Of Cycle, Temperament And Childhood Trauma Are Associated With Lithium Response In Patients With Bipolar Disorders, Delfina Janiri, Alessio Simonetti, Mario Luciano, Silvia Montanari, Evelina Bernardi, Giuseppe Carrà, Andrea Fiorillo, Gabriele Sani

Faculty, Staff and Students Publications

This corrects the article "Type of cycle, temperament and childhood trauma are associated with lithium response in patients with bipolar disorders", 10.

Digital Critical Pedagogy: A Collaborative Narrative Literature Review, Ashley Hinck, Lauren Angelone, Ashley Theuring, Karin Admiraal, Jody Googins, Teresa Young, Wendy Maxian

Mid-Western Educational Researcher

At the intersection of an ongoing global pandemic and equity-focused social movements, critical and digital pedagogies became both necessary and important. Digital ways of teaching made education possible when we could not be in person, and provided alternative modes of learning and thinking, but also exacerbated existing inequalities. In this project, we engage in a narrative literature review to examine how digital critical pedagogy (DCP) has been encountered and framed in higher education pedagogy research from 2020-2022. We ask the question: How is DCP being defined, operationalized, and enacted in the emerging research literature? We argue that the analysis of …

Sampling Potential Hydrologic Impacts From An Underground Fire Lit By The Gray Road Fire, West Medical Lake, Isaac T. Dunmore

2024 Symposium

Eastern State Hospital (ESH) dumped and buried construction related material along the south west shores of West Medical Lake. Based on aerial photos from 1957, the dump was established with pine trees growing on the landfill. The dump is approximately 400 feet long, 50 ft wide and about 30 ft deep or about 6000,00 cubic feet of material. On August 18, 2023, during the Gray Road Fire, the buried site was ignited and has since continued to burn underground. Department of Health Services hired a consultant to analyze soils from the dump using the TCLP method for standard RCRA metals …

Cultivating Leadership: Female Leaders In The Royal Bahamas Defense Force, Jason Styles, Lisa Knowles, Kutisha Ebron

The Journal of Values-Based Leadership

Lessons learned from the impact of COVID-19 have significant implications on crisis management for those serving in the military. Leadership must bear the full brunt of directing subordinates while addressing the crisis at hand. So how do we learn from those volatile, uncertain, complex, and ambiguous (VUCA) situations that arise with no notice? Even more so, those in leadership positions in military branches are instrumental as first responders coming to the national aid of their people. Females continue to enter nontraditional occupational roles, including joining the ranks of leadership in military organizations. This is true in the Royal Bahamas Defense …

Rupert Murdoch: Altruism Inverted, Elizabeth Summerfield

The Journal of Values-Based Leadership

American entrepreneur, television producer, media owner and philanthropist, Ted Turner, once described Rupert Murdoch as “the most dangerous man in the world” (Beahm, 1). This is not an unusual judgement. But it is also one which may contribute to sustaining the Murdoch “brand”, his notoriety and appeal to supporters.

This article examines the deep origins of Murdoch’s cynical worldview, and the source of an ambition that drove him from ownership of a small provincial Australian newspaper to global media mogul. What compelled the need to disseminate often dangerously divisive views on as large a stage as possible, while purporting to …

Changes In Values And Perception Of Life: Natural Disaster Devastates A Mountain Community, Sharifullah Baig, Abida Begum

The Journal of Values-Based Leadership

The mountain communities of Karakorum and the Himalayas in Pakistan are frequently experiencing climate change-induced natural disasters, which are inflicting irreparable losses to their generation's old value system and socio-economic life. Focusing on the value system, this small-scale study explored the change in values and perceptions of a disaster-affected mountain community about natural hazards and its implications for their future lives. Twenty participants from the affected community, including local political activists, religious leaders, teachers, and youth activists, were thoroughly interviewed. The study explored significant deviations from their traditional values of connectedness to each other and with their ancestors' land. The …

A Story Of Resiliency And Success: Beyond The Native American Boarding School, Ritch Eich

The Journal of Values-Based Leadership

No abstract provided.

Remote Work: How Leaders Impact Employee Wellbeing, Russ Carfagno, Jonas Strömbäck, Cheryl Joyner, Gilbert Franco

The Journal of Values-Based Leadership

Leaders face many challenges in motivating team members including maintaining remote workers' sense of organizational inclusion. Remote work and flexible working arrangements (FWA) have increased the complexity. Flexible working arrangements (FWA) provide value to employees and may help with work-life balance yet FWA can create employee loneliness and contribute to higher turnover. This quantitative study looked at whether leadership behavior affected remote workers’ loneliness, and the intention to quit. An online survey was conducted through LinkedIn sampling 92 adults who worked remotely at least 20 hours per week in the United States. The study found that the leader-member relationship does …

Employees Speak Up: Engaging Voices From The Human Services Field, Henry J. Davis, Janna C. Heyman, Linda White-Ryan, Dana Marlowe

The Journal of Values-Based Leadership

This qualitative study aims to understand the perceptions and experiences of human services professionals working within urban communities with respect to their work experiences, compensation, and work-life balance. Focus groups were used to collect data from direct service staff and executive leadership from diverse agencies. This study examined the words and stories, generating the following overarching themes: (1) dedication to agency model and communities served; (2) compensation and responsibilities; (3) reality of work-life balance; and (4) desire for professional growth and personal growth. The results show that while employees expressed personal fulfillment with their work, the issues of compensation, workload, …

The Leader As Life Coach — A Transformative Leadership Perspective, Cam Caldwell

The Journal of Values-Based Leadership

The focus of this paper is on the need for organizations to address the failures of ineffective leadership by adopting a transformative leadership perspective and incorporating seven roles of a Life Coach to encourage, support, and assist employees as they guide them in achieving organizational objectives and excelling personally and professionally. The paper begins by explaining what is meant by a transformative leadership perspective and identifies why that approach to leading organizations is so important. Describing seven roles of the Life Coach, the paper explains how these roles enhance individual and organization performance and offers practical insights for leaders seeking …

Leadershift Today: Balancing Ego And Altruism, Joan F. Marques

The Journal of Values-Based Leadership

This article addresses a behavioral dichotomy that seems to be a prerequisite in proper leadership performance in today’s world, especially in organizational settings that cultivate a culture of wellness and reciprocal progress. While the involved concepts - ego and altruism - are generally familiar human traits, the need for a shift from one to the other once leadership has been attained, has not been discussed as such before. This article therefore aims to evoke within leaders the awareness of the need to shift their mindset, and therefore their behavior, from ego-driven to collective-focused once elevated into a leadership position. The …

Leadership Lessons From Past Global Challenges: Managing The Climate Change Challenge Threatening Sustainable Development, Mostafa Sayyadi Ghasabeh, Michael J. Provitera

The Journal of Values-Based Leadership

On June 5, 2024, Antonio Guterres, Secretary-General of the United Nations, stated in open forum quite unequivocally: "We are playing Russian roulette with our planet. We need an exit ramp off the highway to climate hell. Indeed, climate change is a global challenge to sustainable development.” And an applied solution to this global challenge is a common interest point for all. This viewpoint article presents the key leadership lessons from past global challenges in order to better combat the climate change crisis, alleviate the suffering of those immediately affected, and build a more stable future for all.

Summer/Fall 2024

The Journal of Values-Based Leadership

No abstract provided.

Pfas Variation Through A Wastewater Treatment Facility Process, Aaron A. Fuzak, Chad J. Pritchard

2024 Symposium

PFAS concentrations were measured at a wastewater treatment facility to see the effect the treatment process had on PFAS levels. Samples were collected following an initial clarifier, second clarifier, sand filtration system, ultraviolet light purification system, and then from the effluent produced by the facility and analyzed using EPA Method 533. The effluent from the treatment facility flows from a pipe that enters a wetland, where it evaporates or infiltrates the groundwater. Municipal and septic treated systems are considered possible point sources for PFAS contamination in groundwater. Sampling levels of PFAS after treatment will give insight into the concentrations and …