Digital Commons Network^™

Clinical Trial Research Nurse New Employee Onboarding 30- 60 -90 Day Checklist, Arin Alesia Urban

Master's Projects and Capstones

Problem: The clinical trials research management team was plagued with high nurse turnover and poor clinical documentation due to a lack of seasoned clinical research nurses.

Context: A regional clinical trials team serving 22 hospitals within a Northern California not-for-profit health system.

Interventions: Mixed methods were used to inform the development of new employee onboarding for novice clinical trial nurses utilizing a structured 30-60-90-day checklist, improved communication channels, and continuous mentor support.

Measures: Monthly quality queries and quarterly staff turnover rates were tracked. Employee feedback was collected to assess the interventions' impact.

Results: The number of quality queries was reduced …

Integrated Reference Single-Cell Rna Seq Atlas Of Healthy Human Female Tissues To Expand The Computational Drug Target Discovery Approaches For Female-Directed Non-Hormonal Contraceptives, Zhanel Nugmanova

Dartmouth College Master’s Theses

The ovary is vital for fertility and the maintenance of endocrine homeostasis. It contains heterogeneous cell populations, including oocyte, granulosa, stromal, endothelial, smooth muscle, and immune cell types. Creating a harmonized dataset that enables cross-tissue comparisons, including the ovary, is essential for identifying genes specific to ovarian cell types and for facilitating drug discovery for contraception and fertility purposes. There are very few resources that allow for the assessment of the expression of potential gene targets across human and mouse tissues for female-directed non-hormonal contraceptives. This is because most of these publicly available datasets are from post-menopausal women. Through our …

A Proposal For A Compassionate Behavior Consultation - A Pilot Study, Danina Lynne Thatcher

Theses and Dissertations

Teachers frequently encounter disruptive or other challenging behavior in their classrooms, which often results in poor outcomes for both teachers and students. Behavior consultation is frequently used to assist teachers in managing challenging behavior. However, it is difficult for teachers to implement behavioral interventions with consistent fidelity, even with consultative support. This pilot study utilized a multiple-baseline design to evaluate the effects of a compassionate behavior consultation on teachers' implementation fidelity of evidence-based classroom management practices in three junior high classrooms. It also assessed the teacher's ratings of the social validity of the consultation process and resulting interventions. A compassionate …

Rna Sequencing Reveals Chemotherapy-Induced Changes In Genes Associated With Neurogenesis And Neuronal Function, Bailey Cronin

Theses and Dissertations

Over 310,000 new cases of breast cancer will be diagnosed in 2024, making it the most commonly diagnosed cancer in United States women. Advancements in treatment options such as chemotherapy and radiation have resulted in a 5-year survival rate of 91%. With nearly 4.1 million breast cancer survivors living in the United States today, there is a need for a better understanding of the long-term side effects of these treatments and the impact these may have on the quality of life for these survivors. Reported in up to 78% of cancer patients who received chemotherapy, chemotherapy induced cognitive impairment (CICI), …

Understanding The Mechanisms Of Bio-Effects Of Carbon-Based Nanomaterials In Planta Using “Omics” Approach, Sajedeh Rezaei Cherati

Theses and Dissertations

Carbon-based nanomaterials (CBNs) are recognized as versatile and promising nanomaterials for various applications across multiple fields, including medicine, genetic engineering, plant biology, and agriculture. Notably, carbon nanotubes have been identified as effective in regulating plant growth, reducing plant diseases, and facilitating the targeted delivery of molecules such as DNA and proteins into plant cells and tissues. Despite these advancements, the comprehensive understanding of CBNs' biological impacts, particularly their role in enhancing plant growth and stress tolerance, remains incomplete. Moreover, the use of CBNs in agriculture raises concerns regarding the safety of consuming contaminated plant products and the implications of CBNs …

High-Fidelity Simulation: Methods To Decrease Stress And Anxiety In Prelicensure Nursing Students, Barbara L. Biddle

Dissertations

The purpose of this dissertation literature review was to discuss causes of and methods to reduce stress and anxiety among prelicensure student nurses before and during a simulation so that learning through simulation prepares students to care for patients safely. This literature review focused on the history of simulation in training, feelings of anxiety and stress among nursing students, theories pertinent to nursing simulation, prelicensure students' views and outcomes in simulations, and the research measures that helped reduce stress and anxiety during simulation training.

Impact Of Land Use Dynamics On The Water Yields In The Gorgan River Basin, Masoomeh Yaghoobi, Aram Fathi, Shahryar Fazli, Wenzhao Li, Elham Haghshenas, Vahid Shokri Kuchak, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

This research investigates the future dynamics of water yield services in the Gorgan River Basin in the North of Iran by analyzing land cover changes from 1990 to 2020, using Landsat images and predicting up to 2040 with the Land Change Modeler and InVEST model under three scenarios: continuation, conservation, and mitigation. The results indicate significant shifts in agricultural land impacted water yields, which fluctuated from 324.7 million cubic meters (MCM) in 1990 to 279.7 MCM in 2010, before rising to 320.1 MCM by 2020. The study uniquely assesses the effects of land use changes on water yields, projecting a …

Recidivism: Putting A Stop To The Revolving Door, Kathy Crowder Green

Walden Dissertations and Doctoral Studies

Recidivism is a powerfully adverse factor in the lives of individuals who seek to reintegrate into society and the community at large. In this qualitative research, former inmates who were successfully released and had never been convicted within one year of their release were interviewed to discover the rationale. The research focused on understanding the skills and traits obtained through the Alternative Custody Program that can effectively reduce recidivism. Utilizing a phenomenological design, the purpose of this study was to understand the effects of program participation on the lives of former inmates concerning recidivism. Interviews lasting approximately an hour were …

Job Task Analysis: Exploring A Nonprofit Mental Health Administrative Staff’S Perceptions Of Their Job Duties And Priorities, Ella Faye Warren

Walden Dissertations and Doctoral Studies

Due to a recent expansion, Organization A encountered challenges in aligning its administrative staff duties and responsibilities with the strategic objectives of the organization. This difficulty was driven by the need to accommodate new services and the increasing demand for mental health services within the region. The purpose of this qualitative research study was to explore the job duties the administrative staff at Organization A currently perform, and what were their perceptions concerning the priorities to be fulfilled in the future. The conceptual frameworks of job task analysis and job task inventory guided the data collection process, which involved conducting …

Effect Of Chemical And Mechanical Weed Control On Weed Seed Banks In Rice Field, Uum Umiyati, Dedi Widayat, Yani Maharani

Jurnal Kultivasi

Weed control is essential for ensuring the diversity of weeds on agricultural land. A study was conducted in rice fields in Subang and Cianjur districts, where 24 fields were observed to have varying weed management approaches. The research employed descriptive methods, including surveys to identify weed types and destructive methods to analyze weed seed banks at different depths. The descriptive methods included surveys to identify weed types and destructive methods to analyze weed seed banks at different depths. Each district contained twelve rice fields that reflected diverse environmental conditions and weed control techniques, yet shared a similar age range of …

Implementing Maternal Fetal Triage Index (Mfti) In A High-Risk Obstetrical Setting, Erica Bordenkircher Luna

Master's Projects and Capstones

Problem: The Maternal Fetal Triage Index (MFTI) for obstetric triage provides a systematic method for assessing and assigning acuity. Data evaluated for February 2024 and March 2024 identified the need for improved response times for triage Priority Two, which averaged 28.75 minutes (goal 15 minutes) for a provider to present to the bedside. The average percentage of patients with documented MFTI scores was 70.65% ( goal >80%).

Context: A high-risk 24-bed obstetrical department in an acute care hospital in Northern California that triages over 600 patients monthly with over 400 deliveries in the same period.

Interventions: Real-time observations and staff …

Agile Methodologies On Software Product Project Success, Ying Wang

Harrisburg University Dissertations and Theses

Despite the popularity of using agile methods in software development, many companies still struggle with efficiency problems. These issues lead to financial losses and make it harder for them to compete in the fast-paced software industry. This study aims to find solutions to these problems by looking into effective ways to improve how agile methods are used and to overcome the challenges of putting them into practice. By examining what factors contribute to the success of agile project management, this research hopes to offer useful advice for making software development projects more efficient and productive. The findings from this study …

Approval Letter For The Request For Change (Rfc) To The Butte Priority Soils Operable Unit (Bpsou) Request For Change (Rfc)-Brw-2023-03 To The Final Butte Reduction Works (Brw) Smelter Area Mine Waste Remediation And Contaminated Groundwater Hydraulic Control Site Phase Iii Quality Assurance Project Plan (Qapp) (Phase Iii) (Dated June 29, 2023)., Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

أهمية الإرشاد النفسي في عالم شديد التغير: المُجتمع العُماني أنموذجا سعيد الحسين عبدلي, سعيد الحسين عبدلي

Journal of Arts and Social Sciences

الإرشاد النفسي؛ المجتمع العُماني؛ التغير الاجتماعي؛ جودة حياة الفرد؛ النهضة.

Process Improvement To Reduce The Incidence Of Delirium In An Overflow Unit, Raquel G. Chong

Master's Projects and Capstones

Abstract

Problem: This quality improvement project aims to reduce the incidence of hospital-acquired delirium in an overflow unit, which serves a diverse patient population from medical-surgical and telemetry microsystems. The unit averages 96 delirium episodes annually, costing approximately $3,456,000. The goal is to reduce delirium incidence by 25%, decreasing monthly cases from 8 to 6 by October 31, 2024, and annual cases to 72 by April 2026.

Context: Delirium is a prevalent and severe neuropsychiatric syndrome that significantly affects older hospitalized patients, characterized by acute disturbances in attention, awareness, and cognition.

Interventions: The project introduced a bundle of four interventions …

Changing Landscape Of Liver Transplant In The United States—Time For A New Innovative Way To Define And Utilize The “Non-Standard Liver Allograft”—A Proposal, Rashmi Seth, Kenneth Andreoni

Department of Surgery Faculty Papers

Since the first liver transplant was performed over six decades ago, the landscape of liver transplantation in the US has seen dramatic evolution. Numerous advancements in perioperative and operative techniques have resulted in major improvements in graft and patient survival rates. Despite the increase in transplants performed over the years, the waitlist mortality rate continues to remain high. The obesity epidemic and the resultant metabolic sequelae continue to result in more marginal donors and challenging recipients. In this review, we aim to highlight the changing characteristics of liver transplant recipients and liver allograft donors. We focus on issues relevant in …

The Association Between Amblyopia And The Risks Of Hearing Loss: A Propensity Matched Analysis, Hejin Jeong, Todd Otteson

Student Scholarship

Introduction: Amblyopia occurs due to an imbalance in the visual input between the eyes. This can induce structural changes in the central nervous system and, if left untreated, eventually lead to permanent blindness in the affected eye. As these changes may also impact the auditory system, which closely interacts with the visual system, this study aimed to investigate the risk of hearing loss in patients with amblyopia. Materials and methods: This study was a retrospective review of the electronic medical records contained in a United States national database of medical records. Patients younger than 18 years old with and without …

Systemic Activation Of The Axon Degeneration Executioner Sarm1 Triggers Acute Hyperglycemia, Lillian Spatz

Arts & Sciences Graduate Student Theses and Dissertations

Communication between the nervous system and metabolic tissues directs whole body homeostasis. It is well understood that peripheral tissues respond to neural stimulation or inhibition to modulate energy usage and storage, hormone release, and stress pathways, but the neuroendocrine circuits that drive these outcomes remain ill-defined. Our lab identified sterile alpha and TIR motif containing 1 (SARM1) as the central executioner of axon degeneration in injury and disease models. We found that SARM1 is activated by an elevated NMN/NAD+ ratio and that nicotinamide analogs, including 3-AP and vacor, are converted to NMN-like intermediates that directly bind to SARM1, mimicking the …

Loss Of Resources And Depressive Symptoms After Traumatic Injury, Elizabeth Van Horn

Dissertations

Unintentional traumatic injury is a significant public health problem in the United States. Each year trauma patients sustain loss of physical function, temporary or permanent disability, and additional losses in personal, social, financial, and occupational realms. Loss of resources after injury may contribute to the occurrence of depressive symptoms in trauma patients, which may negatively affect recovery outcomes. The purpose of this research study was to test a model of trauma-related variables that may influence the occurrence of depressive symptoms after traumatic injury. The model developed for this study was based on the Conservation of Resources (COR) model. In applying …

Multi-Omic Analysis Of Huntington's Disease Reveals A Compensatory Astrocyte State, Fahad Paryani, Ji-Sun Kwon, Andrew S Yoo, Et Al.

2020-Current year OA Pubs

The mechanisms underlying the selective regional vulnerability to neurodegeneration in Huntington's disease (HD) have not been fully defined. To explore the role of astrocytes in this phenomenon, we used single-nucleus and bulk RNAseq, lipidomics, HTT gene CAG repeat-length measurements, and multiplexed immunofluorescence on HD and control post-mortem brains. We identified genes that correlated with CAG repeat length, which were enriched in astrocyte genes, and lipidomic signatures that implicated poly-unsaturated fatty acids in sensitizing neurons to cell death. Because astrocytes play essential roles in lipid metabolism, we explored the heterogeneity of astrocytic states in both protoplasmic and fibrous-like (CD44+) astrocytes. Significantly, …

Medical Board Of California, Emily Powers, Marcus Friedman

California Regulatory Law Reporter

No abstract provided.

Board Of Pharmacy, Anuska Lahiri, Marcus Friedman

California Regulatory Law Reporter

No abstract provided.

Board Of Registered Nursing, Maryam Izadshenas, Katie Gonzalez

California Regulatory Law Reporter

No abstract provided.

Veterinary Medical Board, Katie Gonzalez

California Regulatory Law Reporter

No abstract provided.

Department Of Insurance, Alexandra Harten, Marcus Friedman

California Regulatory Law Reporter

No abstract provided.

Key

California Regulatory Law Reporter

No abstract provided.

Improving The Diagnosis And Treatment Of Obstetric Sepsis, Edwije Joseph

Master's Projects and Capstones

Problem: Maternal mortality affects women during four phases of obstetrics, including triage, antepartum, labor & delivery, and postpartum. In the U.S., sepsis is the third leading cause of maternal death. Inconsistent screening practices and delays in recognizing symptoms can occur in any phase. These factors were identified as root causes in a northern California community hospital with 600 monthly deliveries.

Context: Two maternal sepsis cases cost $90,000 annually. A standardized pathway was initiated nationally in October 2023 through the California Maternal Quality Care Collaborative (CMQCC). One regional hospital system initiated a quality improvement project over 5 months within a community …

Decreasing Incivility Through Improved Communication And Teamwork, Marvin Ernest Tamayo

Master's Projects and Capstones

Problem: Workplace incivility (WI), lateral violence (LV), and bullying in healthcare settings are pervasive issues negatively impacting staff morale, turnover rates, and patient care outcomes. High turnover and low employee satisfaction scores from a September 2023 culture of safety survey signaled a toxic work environment characterized by ineffective communication and unprofessional behavior. Context: A 24-bed telemetry-stroke unit at a 172-bed acute care facility in the North Bay area of San Francisco.

Interventions: The Transtheoretical Model (TTM) of behavior change and the Crucial Conversation frameworks were used to improve staff communication and reduce incivility.

Measures: September 2023 and March …

Preventing Hospitalization-Associated Disability, Elizabeth M. White

Master's Projects and Capstones

Problem: Hospital-associated disability (HAD) affects one-third of hospitalized adults, diminishing post-discharge independence and contributing to high mortality rates. Identifying at-risk patients through early assessment of nutritional and functional status upon admission is critical to personalizing care and improving discharge outcomes.

Context: A 24-bed adult medical-surgical unit in a 173-bed suburban hospital in Northern California is part of a large not-for-profit healthcare organization. Interventions: Nursing staff received education on the Enhanced Recovery Medicine (ERM) pathway designed to prevent HAD. A visual display board, maintained and updated by unit champions, gave staff performance feedback. Nursing leadership reviewed admission assessments and addressed barriers …

Improving Stroke Education Scores At A Primary Stroke Center, Jesse J. Young

Master's Projects and Capstones

Abstract

Problem: The COVID-19 pandemic precipitated a significant departure from the nursing profession, leaving healthcare organizations grappling with critical staffing shortages and compromising patient care standards. In 2023, an advanced Primary Stroke Center in a Northern California hospital’s STK-8 scores fluctuated between 80-100%, with an average annual score of 92.8%, putting the facility's primary stroke certification and long-term patient outcomes at risk.

Context: A 24-bed acute stroke and telemetry unit in a Northern California hospital and designated primary stroke center.

Interventions: The following measures were implemented to improve the quality of stroke care and enhance STK-8 compliance, including …