Digital Commons Network^™

The Importance Of Experience: Supporting Pupils’ Creative Writing About The Natural World, Christopher Hanley, David Cooper, Jennifer Rowntree

School of Biological and Marine Sciences

The first part of this article considers the challenge of supporting pupils to write creatively about the natural world. It examines a text by a gifted young writer: Diary of a Young Naturalist by Dara McAnulty. It asks what the challenges might be for pupils who maybe motivated to model their writing on McAnulty’s, but have limited experience of the natural world. Drawing on the scholarly work of John Dixon, Robert Eaglestone and others, the article highlights the importance of pupil experience in the formation of their writerly voice, thereby emphasising the need for writing pedagogies that deepen and enrich …

Treating Higher Education As An Investment, Roger E. Meiners, Andrew P. Morriss

San Diego Law Review

College is one of the costliest investments many people make; yet, prospective students are often not provided accurate information about the cost of college, nor are they provided information about the likely outcomes upon completion of a degree. Rather than address the problem by focusing on ballooning college debt, we propose that the rules that apply to sellers of other services and investments should apply to colleges. Colleges behave much like competitive firms. They engage in costly efforts to lure students. They sometimes produce false or misleading information that gives students the impression of higher payoffs from a degree than …

The “Horizontal Separation Of Powers” After National Pork Producers Council V. Ross, Bradley W. Joondeph

San Diego Law Review

The Supreme Court’s decision in National Pork Producers Council v. Ross (NPPC) held that California’s Proposition 12—which forbids the sale of pork in the state derived from pigs born of sows confined “in a cruel manner”—does not violate the dormant Commerce Clause. Specifically, the Court held that the law neither regulates “extraterritorially” (despite the fact that nearly all the pork sold in California is produced in other states) nor imposes an undue burden on interstate commerce. While the Court’s rationale in NPPC was somewhat fractured, the decision nonetheless established some important points. First, a state law’s out-of-state “practical …

Is There Room In The Classroom For The First Amendment? Defining The Doctrine For Teachers’ Classroom Speech, J.P. Riley

San Diego Law Review

Many public school teachers face a daunting question: What are they allowed to say in the classroom? States are actively passing legislation restricting instruction and discussion regarding Critical Race Theory, sexual orientation, and gender identity. Yet, there is a circuit split in First Amendment jurisprudence regarding the bounds of teachers’ classroom speech. Do these purported curricular restrictions extend to all teachers’ classroom speech? Do these restrictions silence teachers’ lived identities related to race, sexual orientation, and gender identity? The Supreme Court should resolve the circuit split in teachers’ classroom speech analysis to provide teachers the protection to share their lived …

Prosecutors In The Passing Lane: Racial Disparities, Public Safety, And Prosecutorial Declinations Of Pretextual Stops, Donald Braman, Jared Fishman, Lily Grier, Kevin Himberger, Jarvis Idowu, J.J. Naddeo, Rory Pulvino, Jess Sorensen, Joanie Weaver

San Diego Law Review

In response to a growing set of empirical studies demonstrating their widespread discriminatory effects, pretextual stops have been subjected to decades of criticism from scholars, the public, and jurists. However, pretextual stops have been defended by some as a necessary public safety measure, particularly in the fight against violent gun crimes. Following a series of highly publicized police shootings of unarmed Black drivers during pretextual stops, and in the absence of substantial judicial or legislative guidance, a growing number of prosecutors have developed policies deprecating the prosecution of pretextual stops absent a clear public safety benefit. Without empirical evaluations of …

Emerging Role Of Mucins In Antibody Drug Conjugates For Ovarian Cancer Therapy, Shabnam Malik, Mohammed Sikander, Natasha Bell, Daniel Zubieta, Maria C. Bell, Murali Yallapu, Subhash Chauhan

School of Medicine Publications

Ovarian cancer stands as the deadliest gynecologic malignancy, responsible for nearly 65% of all gynecologic cancer-related deaths. The challenges in early detection and diagnosis, coupled with the widespread intraperitoneal spread of cancer cells and resistance to chemotherapy, contribute significantly to the high mortality rate of this disease. Due to the absence of specific symptoms and the lack of effective screening methods, most ovarian cancer cases are diagnosed at advanced stages. While chemotherapy is a common treatment, it often leads to tumor recurrence, necessitating further interventions. In recent years, antibody-drug conjugates (ADCs) have emerged as a valuable tool in targeted cancer …

Economic Contribution Of U.S. Aquaculture Farms, Ganesh Kumar, Shraddha Hegde, Jonathan Van Senten, Carole Engle, Noah Boldt, Matthew Parker, Kwamena Quagrainie, Benedict Posadas, Frank Asche, Madan Dey, Suja Aarattuthodi, Luke A. Roy, Russell Grice, Quentin Fong, Michael Schwarz

Department of Agricultural Economics Faculty Publications

Economics is the study of the allocation of scarce resources to meet human wants and needs and has a critical role to play in addressing challenges related to environmental sustainability, community resilience, and food security. In the context of aquaculture, the key to such a discussion is understanding the linkages of aquaculture farming businesses with other economic sectors and how policy decisions that affect aquaculture result in economic ripples throughout local, regional, and national economies. The only previous national estimates of the economic contributions of U.S. aquaculture are nearly 30 years old. The current study was based on comprehensive data …

Im/Mobilities During The Covid-19 Pandemic: Perspectives From International Graduate Students Studying In The Southern United States, Christine W. Yao, Kaitlyn Hall, Simone Gause, Leslie Jo Shelton

Counseling, Leadership, and Research Methods Faculty Publications and Presentations

The background of this study is situated within the COVID-19 pandemic as an acute challenge with chronic issues that international graduate students have faced continuously. With the pandemic serving as a critical incident, we highlight the political, systemic, and personal fragilities of international graduate students studying in the southern United States. The methods for our study were informed by a narrative inquiry approach combined with a systematic literature review to connect with the conceptual framework of Avison and Turner’s chronic strains and Robertson’s conception of timescales. The findings highlight three broad themes: shifting immigration policies and travel uncertainty, institutional responses, …

Pan-Cancer Proteogenomics Expands The Landscape Of Therapeutic Targets, Sara R Savage, Xinpei Yi, Jonathan T Lei, Bo Wen, Hongwei Zhao, Yuxing Liao, Eric J Jaehnig, Lauren K Somes, Paul W Shafer, Tobie D Lee, Zile Fu, Yongchao Dou, Zhiao Shi, Daming Gao, Valentina Hoyos, Qiang Gao, Bing Zhang

Faculty, Staff and Students Publications

Fewer than 200 proteins are targeted by cancer drugs approved by the Food and Drug Administration (FDA). We integrate Clinical Proteomic Tumor Analysis Consortium (CPTAC) proteogenomics data from 1,043 patients across 10 cancer types with additional public datasets to identify potential therapeutic targets. Pan-cancer analysis of 2,863 druggable proteins reveals a wide abundance range and identifies biological factors that affect mRNA-protein correlation. Integration of proteomic data from tumors and genetic screen data from cell lines identifies protein overexpression- or hyperactivation-driven druggable dependencies, enabling accurate predictions of effective drug targets. Proteogenomic identification of synthetic lethality provides a strategy to target tumor …

Antibody Therapies For Alzheimer's Disease, Alexandra Zerr

University Honors Theses

Alzheimer's Disease (AD) is the leading cause of dementia worldwide. Patients with this condition first experience mild cognitive impairment, followed by the loss of memory, cognitive skills, identity, and the ability to perform daily tasks unassisted, eventually culminating in death.

The dominant hypothesis for the mechanism of Alzheimer's, the amyloid cascade hypothesis, based on early-onset AD, suggests that amyloid plaques formed by Aβ peptides cause a cascading effect involving an increase in toxic tau protein, which is correlated with the disease progression of Alzheimer's patients. While the mechanism of late sporadic AD is not fully understood, this has been used …

Binary Gendered Language: A Qualitative Study Of Psu Students, Dakota Abercrombie

University Honors Theses

This study explores experiences of gendered language in use in academia among two marginalized groups: women and those identifying beyond the gender binary. Guided by the theory of linguistic relativity this study attempts to understand specific ways in which gendered language, including generic language may show up and contrasted within these groups. While this data is not generalizable, the findings indicate that both women and nonbinary students experience binary pronoun use in written formats such as syllabi. However, nonbinary students describe more negative feelings associated with this experience. We also noted participants' gender identities intersecting with other identities, leading to …

Loss Of Transient Receptor Potential Channel 5 Causes Obesity And Postpartum Depression, Yongxiang Li, Tessa M Cacciottolo, Na Yin, Yang He, Hesong Liu, Hailan Liu, Yuxue Yang, Elana Henning, Julia M Keogh, Katherine Lawler, Edson Mendes De Oliveira, Eugene J Gardner, Katherine A Kentistou, Panayiotis Laouris, Rebecca Bounds, Ken K Ong, John R B Perry, Inês Barroso, Longlong Tu, Jonathan C Bean, Meng Yu, Kristine M Conde, Mengjie Wang, Olivia Ginnard, Xing Fang, Lydia Tong, Junying Han, Tia Darwich, Kevin W Williams, Yongjie Yang, Chunmei Wang, Shelagh Joss, Helen V Firth, Yong Xu, I Sadaf Farooqi

Duncan NRI Faculty and Staff Publications

Hypothalamic neural circuits regulate instinctive behaviors such as food seeking, the fight/flight response, socialization, and maternal care. Here, we identified microdeletions on chromosome Xq23 disrupting the brain-expressed transient receptor potential (TRP) channel 5 (TRPC5). This family of channels detects sensory stimuli and converts them into electrical signals interpretable by the brain. Male TRPC5 deletion carriers exhibited food seeking, obesity, anxiety, and autism, which were recapitulated in knockin male mice harboring a human loss-of-function TRPC5 mutation. Women carrying TRPC5 deletions had severe postpartum depression. As mothers, female knockin mice exhibited anhedonia and depression-like behavior with impaired care of offspring. Deletion of …

The Dna Methylome Of Pediatric Brain Tumors Appears Shaped By Structural Variation And Predicts Survival, Fengju Chen, Yiqun Zhang, Lanlan Shen, Chad J Creighton

Faculty, Staff and Students Publications

Structural variation heavily influences the molecular landscape of cancer, in part by impacting DNA methylation-mediated transcriptional regulation. Here, using multi-omic datasets involving >2400 pediatric brain and central nervous system tumors of diverse histologies from the Children's Brain Tumor Network, we report hundreds of genes and associated CpG islands (CGIs) for which the nearby presence of somatic structural variant (SV) breakpoints is recurrently associated with altered expression or DNA methylation, respectively, including tumor suppressor genes ATRX and CDKN2A. Altered DNA methylation near enhancers associates with nearby somatic SV breakpoints, including MYC and MYCN. A subset of genes with SV-CGI methylation associations …

Lysineless Hibit And Nanoluc Tagging Systems As Alternative Tools For Monitoring Targeted Protein Degradation, Hanfeng Lin, Kristin Riching, May Poh Lai, Dong Lu, Ran Cheng, Xiaoli Qi, Jin Wang

Faculty, Staff and Students Publications

Target protein degradation (TPD) has emerged as a revolutionary approach in drug discovery, leveraging the cell’s intrinsic machinery to selectively degrade disease-associated proteins. Nanoluciferase (nLuc) fusion proteins and the NanoBiT technology offer two robust and sensitive screening platforms to monitor the subtle changes in protein abundance induced by TPD molecules. Despite these advantages, concerns have arisen regarding potential degradation artifacts introduced by tagging systems due to the presence of lysine residues on them, prompting the development of alternative tools. In this study, we introduce HiBiT-RR and nLucK0, variants devoid of lysine residues, to mitigate such artifacts. Our findings demonstrate that …

Translational Potential Of Mouse Models Of Human Metabolic Disease, I Sadaf Farooqi, Yong Xu

Children’s Nutrition Research Center Staff Publications

Obesity causes significant morbidity and mortality globally. Research in the last three decades has delivered a step-change in our understanding of the fundamental mechanisms that regulate energy homeostasis, building on foundational discoveries in mouse models of metabolic disease. However, not all findings made in rodents have translated to humans, hampering drug discovery in this field. Here, we review how studies in mice and humans have informed our current framework for understanding energy homeostasis, discuss their challenges and limitations, and offer a perspective on how human studies may play an increasingly important role in the discovery of disease mechanisms and identification …

Postacute Sequelae Of Sars-Cov-2 Infection In The Pre-Delta, Delta, And Omicron Eras, Yan Xie, Taeyoung Choi, Ziyad Al-Aly

2020-Current year OA Pubs

BACKGROUND: Postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) can affect many organ systems. However, temporal changes during the coronavirus disease 2019 (Covid-19) pandemic, including the evolution of SARS-CoV-2, may have affected the risk and burden of PASC. Whether the risk and burden of PASC have changed over the course of the pandemic is unclear.

METHODS: We used health records of the Department of Veterans Affairs to build a study population of 441,583 veterans with SARS-CoV-2 infection between March 1, 2020, and January 31, 2022, and 4,748,504 noninfected contemporaneous controls. We estimated the cumulative incidence of …

The Effect Of Current Ratio, Net Profit Margin, Roa, Company Age, On Profit Growth& Stock Prices During The Covid-19 Pandemic, Gayatri Rejeki, Erwin Harinurdin

Jurnal Administrasi Bisnis Terapan

The purpose of this study was conducted to examine the effect of Current Ratio (CR), Net Profit Margin (NPM), Return On Assets (ROA), and Company Age on Profit Growth and the Effect of Profit Growth on Stock Prices on the Indonesia Stock Exchange 2018-2021. This research is a quantitative type. The population in this study are companies on the LQ45 index listed on the Indonesia Stock Exchange in the 2018-2021 period with a total sample of 34 companies. This study used a purposive sampling method. Methods of data analysis using descriptive statistics, comparative analysis, multiple linear regression analysis, and classical …

Infrazygomatic Crest Zone Regarding Orthodontic Mini-Implants – A Review, Abbas F. Alsaeedi, Mehdi Abdul-Hadi Alrubayee, Gautham Sivamurthy

Maaen Journal for Medical Sciences

Background: Temporary anchorage devices have revolutionized fixed orthodontic appliance treatment through anchorage controlling in the clinic and play an essential role in resolving many complex cases. There is a possible risk for roots injury while using inter-radicular micro-implants, this is due to limited space. Therefore, the infrazygomatic crest area can be an alternative mini-implant insertion site in upper arch.

Objectives: To review orthodontic temporary anchorage devices (mini-implants) used in infrazygomatic crest in terms of: method of application, material, size of mini-implants, failure rate and advantage over inter-radicular mini-implants.

Sources: Internet sources, such as Google and Scholar PubMed. Selection of study: …

Investigating The Impact Of Semaglutide On Hepatic Oxidative Stress In Obese Male Rats Induced By High-Fat Diet, Duha Haitham Mohammed Alzubaidy, Zahraa Jawad Kadhim Al-Isawi

Maaen Journal for Medical Sciences

Background: The prevalence of obesity is on the rise, and with it comes the burden on healthcare systems due to the increased likelihood of complications such as diabetes, heart disease, hypertension, cancer, and many more. Obesity manifests in the body as an increase in adipose tissue and the production of harmful chemicals by fat cells. One of the pathological changes recorded in obesity is the excessive amount of reactive oxygen species and oxidative stress. An effective medication for oxidative stress and glucose metabolism regulation, including glucose variability is semaglutide. Objective: This study aims to investigate the impact of semaglutide …

Osteoporosis: The Most Common Postmenopausal Women Disorder: A Review, Iman Hussein Naser, Zahraa Abed Al-Kareem, Hiba Salah Mahdi, Amal Umran Mosa, Mazin Hamid Ouda

Maaen Journal for Medical Sciences

Osteoporosis is a common disease affecting both sex ( male and female). It is non-communicable disease characterized by silent and slowly development. That mean it start at several years before diagnosed since it is usually diagnosed when the patient have fractures or bone disease. Osteoporosis can affect people in all countries. For example, 75 millions of patients are European, American, and Japanese. Postmenopausal is the most common cause of developing osteoporosis. That is because the effect of hormonal alterations during this period. Menopausal term is used to describe woman who have amenorrhea for consecutive 12 month or more. Osteoporosis are …

Development Of Pork Meatballs Supplemented With Commercial Soluble Dietary Fibres And Mimic In Vitro Simulated Gastrointestinal Digestion, Chonlada Srikamwang, Pirawan Chaiwan, Sarana Rose Sommano, Malaiporn Wongkaew

International Journal of Health and Allied Sciences

This study investigated the effects of supplementing tapioca starch with commercially soluble dietary powder in meatballs to develop a low-glycaemic index (GI) food for people with high blood sugar levels. This work evaluates the physicochemical characteristics, texture profile analysis (TPA), proximate composition, and digestibility of carbohydrate in meatballs supplemented with commercial soluble dietary powder using 3x3 factorial completely randomised design. The physicochemical characteristics findings indicate that the colour values of GI meatballs, including L*, a*, and b*, ranged from 63.60 to 68.49, 1.52 to 3.05, and 13.86 to 16.56, respectively. The colour difference values of meatballs containing dietary fibre in …

Determination Of Value Adding Macromolecules From Ok-Rong Mango Peel Biomass, Pirawan Chaiwan, Piyachat Sunanta, Cholada Srikawang, Shashanka K. Prasad, Sarana Rose Sommano

International Journal of Health and Allied Sciences

Mango is a significant economic fruit in Thailand, with an annual production of up to 500,000 tonnes. Ok-Rong is a popular mango type in Thailand, known for its higher price compared to other varieties. However, during the processing, biomass accounts for over 50% of the overall weight and causes a serious environmental problem. However, it has the potential to serve as a source of nutritional components, commonly used as additives in functional food. This study aimed to investigate the nutritional value of the peel, including proximate analysis, amino acid profile, and polysaccharide profile. The proximate analysis results indicate that the …

Effect Of Repeated Heating On Chemical Properties Of Selected Edible Plant Oil And Its Health Hazards, J Prarthana, Nischitha Nischitha, Shraddha Shraddha, Ramith Ramu

International Journal of Health and Allied Sciences

Increase in the cost price of edible oil, has forced to reuse the cooking oil especially in frying. Repeated cooking of oil brings about lot of structural changes ideally not suitable for consumption. The present study aims at comparing the structure and chemical changes like acid value, peroxide value, saponification, iodine value of three different commonly used edible oil viz sunflower oil, coconut oil & rice bran oil after successive heating & cooling. Oils were heated four times for 45 minutes, followed by repeated cooling for 2 hours. The results indicates that the acid values of all three oils (0.32- …

Influence Of Attachment Styles On Oral Hygiene Status Of 9e12 Year Old Children - A Cross Sectional Study, Svsg Nirmala, Supriya Thambireddy, Sivakumar Nuvvula

International Journal of Health and Allied Sciences

Background: Oral hygiene, which is measured by the status of plaque-free tooth surfaces, is essential for the promotion of oral health. Bowlby suggests that children develop internal working models in earlier stages depending on their attachment relationships with parents.

Aim: To determine the prevalence of attachment styles in 9-12-year-oldschool children and also to note the oral hygiene status of children based on their attachment style.

Materials and methods: A descriptive cross-sectional study was conducted on three eighty-four 9–12-year-old school children in the Nellore district using the cluster sampling method. Attachment style was measured using 15-item questionnaires developed from the Attachment …

Development And Validation Of The Attitude And Perceptions Questionnaires For Healthcare Professionals And General Public Towards Digital Health Technologies (Dht): A Single – Centre Study, Jehath Syed, Nikita Pal, M Ramesh, Sri Harsha Chalasani

International Journal of Health and Allied Sciences

Introduction: The increasing development of artificial intelligence (AI) systems in medicine, driven by researchers and entrepreneurs, has led to enormous expectations for medical care advancement. This study aimed to develop and validate a questionnaire to explore the attitudes and perceptions of healthcare professionals and patients towards digital health technologies.

Methods: Questionnaires were developed based on an extensive literature search and expert opinions. The questionnaires were subjected to content and face validations. Multirater kappa coefficient of agreement was performed for determining interrater agreement.

Results: Two questionnaires were developed, one 11-item for healthcare professionals and 14-item for the general public. Seven out …

Prevalence Of Alcohol Dependence Among Rural Residents Of Mysuru District: A Community-Based Cross-Sectional Study, Preethi K, Sunil Kumar D, Lekha Shree Alagesan

International Journal of Health and Allied Sciences

Psychoactive substance use, including alcohol and illicit drugs, poses substantial health risks. A community-based study in rural areas of Mysuru district, employed the AUDIT-C score to assess alcohol dependence. The prevalence of alcohol dependence among rural residents was 77.5%, with males (94.8%) exhibiting higher rates than females (5.1%), although not statistically significant (P > 0.05). Sociodemographic factors showed no significant association (P > 0.05) with alcohol consumption. The study underscores the considerable alcohol consumption in rural area of Mysuru, underscoring the need for targeted awareness programs aimed at controlling and preventing alcohol dependence to enhance public health outcomes.

Qualification Of 3d-Printed Titanium Volume-Optimized Propulsion Tanks For Small Satellites, Robert Fowler, Ryan Thibaudeau, Weston Allen, Twinkle Pandhi, Sid Raje, Matt Karesh, Stefka Petkova, Ryan Askew, Fernando Ferreira, Jake Schwartzman

Small Satellite Conference

The current state of the art for small satellite chemical propellant tanks is limited in design customization, is expensive, and is volumetrically inefficient within the cuboid volumes of small satellite buses. Space Dynamics Laboratory and Velo3D Inc. partnered to develop propulsion tank technology that solves these challenges using metal additive manufacturing (AM). We designed, analyzed, built, heat-treated, post-machined, precision cleaned, and qualification tested a titanium 6A14V volume-optimized 3D-printed propulsion tank with an integral printed propellant management device (PMD). They are rated for a maximum expected operating pressure of 400 psi. These tanks are 3D-printed in the desired cuboid mission geometries …

Edge Node: A Multi-User Rendezvous And Proximity Operations On-Orbit Testbed, Darren Rowen, Joel Rivera, Susan Lui, Joseph Gangestad, Alex Gallenberger, Binh Dinh, Phaedrus Leeds, Noah Weiner, Rudd Johnson, Christopher Day, Alexander Christidis

Small Satellite Conference

Edge Node is a multi-small satellite free-flying, collaborative testbed for formation flight and rendezvous and proximity operations (RPO) under development by The Aerospace Corporation that is planned for launch in 2026- 2027. Edge Node will develop and advance local space situational awareness sensors for CubeSat-scale platforms and facilitate the development and qualification of autonomous on-board RPO software for CubeSats. Edge Node is intended to serve as a multi-user on-orbit facility through which technologies and algorithms can be tested and validated in the authentic operational low Earth orbital environment. Edge Node leverages recent advances in miniature sensor and computing hardware for …

From Design To Orbit: Engineering Sub-Arcsecond Cubesat Pointing Performance On Pathfinder-3, Paaras S. Agrawal, Christian O. Fuller, Kyle R. Kung, Jeremiah J. Dimatteo

Small Satellite Conference

Pathfinder-3 (PTD-3) spacecraft is the third vehicle of the NASA Pathfinder Technology Demonstrator (PTD) series, which are a collection of 6U CubeSats launched in Low Earth Orbit (LEO) to demonstrate innovative payload capabilities. The payloads are hosted on commercially developed satellites designed and manufactured by Terran Orbital Corporation (TOC) with a goal to support a wide array of technology demonstration missions through a flexible architecture that can be tailored for custom needs. PTD-3 hosts a high data rate laser communications payload that does not include its own pointing acquisition and control system, and, therefore, is dependent on accurate bus pointing …

Characterizing A Chip Scale Atomic Clock In Low Earth Orbit, Mikaela Dobbin, Austin Hunter, William Gravel, Conner Parker, Penina Axelrad

Small Satellite Conference

The University of Colorado Boulder has developed an experiment to characterize the behavior of a chip-scale atomic clock (CSAC) in space, conducted on the MAXWELL CubeSat mission. This experiment integrates a CSAC as an external oscillator to the onboard GPS receiver, enabling clock characterization through real-time estimates of clock bias, GPS pseudorange, and carrier phase measurements. These data will demonstrate the CSAC's short and long-term stability and its sensitivity to the space environment.

This paper evaluates the observation of CSAC performance using GPS within the constraints of the MAXWELL mission. The results, derived from tests with realistic orbit and spacecraft …