Digital Commons Network^™

Effects Of A Complexity-Based Expressive Language Treatment On Comprehension In Children With Down Syndrome: A Preliminary Investigation, Aliese M. Pedro

Theses and Dissertations

This study examined whether a complexity-based expressive morphosyntactic intervention targeting auxiliary BE questions improves morphosyntactic, vocabulary, and narrative comprehension in adolescents with Down syndrome (DS). Two participants (ages 15;11 and 14;2) received intervention delivered over 15 and 12 sessions, respectively, using a structured narrative-based protocol. Comprehension was assessed pre- and post-intervention using the Clinical Evaluation of Language Fundamentals-Fifth Edition (CELF-5) Following Directions subtest, the Peabody Picture Vocabulary Test-Fifth Edition (PPVT-5), the Test of Narrative Language-Second Edition (TNL-2), and the Test of Early Grammatical Impairment (TEGI) Grammaticality Judgment (GJ) task. Results indicate no reliable or clinically significant improvements in comprehension across …

An Exploration Of The Lived Experience Of Married Couples Impacted By Aphasia, Summer Ewell

Theses and Dissertations

People with aphasia and those closest to them experience changes in their lives and relationships due to aphasia. These changes may be particularly impactful for married couples. The aim of this study was to increase understanding of the dynamic and complex experiences of couples impacted by aphasia and to add personal perspectives to the creation of practical treatments and resources. Twenty-eight participants (14 married couples) participated in both individual and couples' semi-structured interviews, resulting in 42 total interviews for analysis. Participants answered open-ended questions about aphasia's influence on the couple's communication and relationship. Interviews were then transcribed orthographically and coded …

Quantum And Structural Effects Captured Via A Statistical Method: The Sacm Applied To Hcn And Hnc Colliding With Co, F. Tonolo, Ernesto Quintas-Sánchez, A. Batista-Planas, Richard Dawes, F. Lique

Chemistry Faculty Research & Creative Works

This study spotlights the statistical adiabatic channel model as an efficient and accurate method for deriving low-temperature (de)-excitation rate coefficients for collisions induced by heavy projectiles. For such systems, fully quantum treatments become intractable, while quasi-classical methods fail at low temperature. Here, we demonstrate that the statistical adiabatic channel model overcomes these limitations by combining statistical sampling with an adiabatic channel representation. Its application to the HCN and HNC isomers colliding with CO yields rate coefficients in quantitative agreement with full quantum results benchmarked for the lowest total angular momentum. These systems are relevant for modeling cometary comae, where reliable …

Forecasting Interborough Express Ridership Using Network-Based Station Typologies And Direct Demand Models, Fomba Kassoh

Student Theses

Forecasting ridership for new transit infrastructure is difficult in the absence of observed outcomes, particularly under domain shift between an existing system and a proposed corridor. This study develops a station-level direct demand modeling (DDM) framework to forecast average weekday ridership for the proposed Interborough Express (IBX) in New York City — a 14-mile circumferential rapid transit corridor connecting Brooklyn and Queens. The approach pairs unsupervised learning with supervised estimation in a common feature space defined by transit service, accessibility, and built-environment characteristics. K-means clustering identifies latent station typologies (node–place regimes), and IBX stations are projected into this topology to …

Harry Robert Fox, Jr. Papers, 1956-1994, Harry Robert Fox Jr.

Center for Restoration Studies Archives, Manuscripts and Personal Papers Finding Aids

No abstract provided.

Michael "Mike" Moore Young, 1930-1972, Michael M. Young

Center for Restoration Studies Archives, Manuscripts and Personal Papers Finding Aids

No abstract provided.

World Convention Of Churches Of Christ Records, 2008, World Convention Of Churches Of Christ

Center for Restoration Studies Archives, Manuscripts and Personal Papers Finding Aids

No abstract provided.

Front Matter, Dewey Studies

Dewey Studies

No abstract provided.

Truth, Justness, Falseness, And Lie In The Deweyan Sense, Mathieu Gagnon

Dewey Studies

No abstract provided.

Bridging The Justice Gap: A Comparative Study Of Legal Aid Marketing In Canada, Australia, And The United States, Farah O. Haq

Student Theses and Dissertations

Access to justice remains a central challenge across legal systems, particularly for immigrants and refugees, Indigenous communities, and survivors of domestic violence. While legal aid organizations play a critical role in bridging this gap, their effectiveness increasingly depends on how clearly and compassionately they communicate legal information online to their target audience. This thesis conducts a comparative content analysis of nine nonprofit legal aid organizations in the United States, Canada, and Australia, three countries united by a common law tradition but divided by the communication barriers their communities face, examining 180 social media posts and nine websites through the lens …

Open For Anti-Racism: Assignment Example, Dorina Tila

Open Educational Resources

Economists have scarcely investigated and analyzed the racial discrimination topic despite the prevalent presence of economic racism and inequality in the United States. For example, the article “Race and Racism in Economics” by Cihak, Mlachila, and Sahay (2020) present some shuttering findings. Out of 7,920 articles from the top 10 economic journals published during a decade from 2010-2020, only 0.2 percent cover issues of race, racial inequality, and racism. There is a scarcity of articles analyzing this topic that affects large communities.  However, students need to be exposed to this reality and some unintended consequences of regulations that might aim …

Clonal Reshaping And Clinical Outcomes After Rechallenge In Ici-Associated Myocarditis: Integrated Single-Cell And Tcr Repertoire Analysis, Jian Zhang, Xiaozhen He, Yerui Zhang, Xianling Qian, Yu Song, Shilong Zhang, Zheng Li, Zhiming Wang, Bo Lu, Qingqing Cai, Leilei Cheng, Yan Wang

Center for Translational Medicine Faculty Papers

BACKGROUND: Immune checkpoint inhibitor-associated myocarditis (ICIAM) poses significant challenges for cancer immunotherapy, particularly regarding the safety and efficacy of immune checkpoint blockade (ICB) rechallenge.

METHODS: The present study analyzed 23 cases of ICIAM by integrating longitudinal clinical data with single-cell RNA sequencing and T-cell receptor profiling of peripheral blood mononuclear cells (PBMCs) obtained from three representative patients before and after ICB rechallenge. The single-cell cohort comprised two patients who experienced recurrent irAEs upon rechallenge and one patient who did not develop recurrent irAEs.

RESULTS: Among 12 patients (52%) who experienced recurrent irAEs upon rechallenge, myocarditis recurrence occurred in 8 cases, …

Target Trial Of Glucagon-Like Peptide-1 Agonists Versus Dipeptidyl Peptidase-4 Inhibitors And Mortality In Hemodialysis, Dustin Le, Duncan Kilpatrick, Walter K. Kraft, Morgan E. Grams, Bernard G. Jaar, Jung-Im Shin

Division of Nephrology Faculty Papers

INTRODUCTION: The comparative effectiveness of glucagon-like peptide-1 (GLP-1) agonists (GLP-1s) versus dipeptidyl peptidase-4 (DPP-4) inhibitors (DPP-4s) in hemodialysis is unknown.

METHODS: Using 2011 to 2021 US Renal Data System and Medicare claims data, we emulated a target trial comparing new users of GLP-1s versus DPP-4s with patients who survived ≥ 90 days on in-center hemodialysis before medication initiation. We used inverse probability of treatment weighting (IPTW) and Cox proportional hazards models to estimate hazard ratios (HRs).

RESULTS: We identified 3671 GLP-1 and 12,039 DPP-4 users. After IPTW, mean age was 63 years, 52% male, 63% White, and mean body mass …

Leading In The Classroom Empowering Educators In Paraguay, Carissa State Gober, Donna Zerr, Jason Clemensen, Aaron Hurt

Open Educational Resources - Teaching and Learning

Here’s a simplified version of the abstract with clear, straightforward language:

Abstract

In May 2026, faculty and staff from Pittsburg State University gave presentations in Asunción and Ciudad del Este, Paraguay. The sessions focused on practical topics for educators and students, including strategies for teaching English to speakers of other languages (TESOL), ways to use artificial intelligence in education, leadership tips, and international opportunities available at Pittsburg State University. Each session encouraged participation and discussion, helping connect Paraguayan educators and students with new ideas and resources. These events showed the university’s commitment to building international partnerships, supporting teachers with useful …

Coleman V. Chen

All Decisions

The Civil Court found in the tenant's favor in an illegal lockout case where the tenant signed a lease but was never allowed to move in after refusing to pay an unlawfully demanded security deposit. The court affirmed that physical possession is not required to bring an illegal lockout proceeding: as soon as a lease is executed and delivered, the tenant acquires the right to possession as of the commencement of the term, even without physical possession.

Widespread Concern Over Gas Prices In Nh As Consumer Confidence Shows Sudden Slump 5/28/2026, Unh Survey Center

All UNH Survey Center Polls

Six in ten New Hampshire residents are worried about paying for gas and believe gasoline prices will rise over the next twelve months. Two-thirds believe President Trump is very responsible for the increase in gasoline prices. As gas prices increase, Granite Staters are less positive about their personal finances compared to a year ago and many expect to be worse off a year from now. New Hampshire residents are also downbeat on the national economy, as nearly half anticipate bad times over the next year and two-thirds believe the economy is getting worse.

Most Mainers Worried About Gas Prices, Nearly Half Have Driven Less Amid Price Spike 5/28/2026, Unh Survey Center

All UNH Survey Center Polls

Majorities of Mainers are worried about the cost of gasoline and believe gas prices will continue to rise. Nearly half have limited their travel because of the price increase, while more than a third have cut spending on non-essentials in their life. More than three-quarters believe oil companies and President Trump are very or somewhat responsible for the rise in the price of gasoline. Mainers are generally pessimistic about the economy; half expect bad economic times over the next year and nearly two-thirds believe the economy is getting worse. More than half of Mainers say their personal finances have declined …

Hope And Resilience For Families Affected By Alcoholism Within The Deaf And Hard Of Hearing (Dhh) Community, Jessica Ellen Kuehne

Faculty Publications and Presentations

This presentation will cover research-based information about family alcoholism, children of alcoholics (COA), and adult children of alcoholics (ACOA) and explore how it impacts the Deaf community. Cultural considerations regarding alcohol use will be included in the presentation. The purpose of the workshop is to engage participants in increasing their knowledge and understanding of working with the unique group. It is important to note that the lack of studies and resources focusing on family alcoholism which impacts a group of COAs and ACOAs in the Deaf community. The presentation will begin with a brief overview of how family alcoholism impacts …

The Relationship Between Musical Ability And Perceptual Skills For Speech Motor Learning In Young Adults, Emily Catmull

Theses and Dissertations

Speech motor learning is the multimodal process of acquiring speech sounds. Speech motor learning is trained through speech-language pathologist intervention in individuals across the lifespan. Previous research has explored which factors can influence speech motor learning, such as musical experience or training, which is the subject of this study. Sixty young adult participants (four male, 56 female) were recruited as part of a larger study that examined four possibly influential factors: bilingualism, phonetic knowledge, perceptual skills, and musical experience. Since the adult population has already acquired all the speech sounds in English, learning was measured using nonnative consonant clusters. Participants …

Panda-Plus-Bench: A Clinical Benchmark For Evaluating The Robustness Of Ai Foundation Models In Prostate Cancer Diagnosis, Joshua L. Ebbert, Dennis Della Corte

Faculty Publications

Artificial intelligence foundation models are increasingly deployed for prostate cancer Gleason grading, where GP3/GP4 distinction directly impacts treatment decisions (active surveillance vs. intervention). However, these models may achieve high validation accuracy by learning specimen-specific artifacts rather than generalizable biological features, limiting real-world clinical utility. We introduce PANDA-PLUS-Bench, a curated benchmark dataset derived from expertly annotated prostate biopsies designed specifically to quantify this failure mode. The benchmark comprises nine carefully selected whole slide images from nine unique patients containing diverse Gleason patterns, with non-overlapping tissue patches extracted at both 512 × 512 and 224 × 224-pixel resolutions across eight augmentation conditions. …

Structure Of Ergosteryl-Aspartate Synthase Reveals How An Entrapped Trna Is Used Like A Prosthetic Swinging Arm In The Synthesis Of Aminoacylated Sterols, Hanako Murayama, Nathaniel Yakobov, Nassira Mahmoudi, Sasha Legrosdidier, Nicolas Fournier, Solène Zuttion, Kanata Matsumoto, Michihiro Nishimura, Jingwei Ji, Bruno Senger, Laurence Huck, Howard Gamper, Yoshiaki Kise, Ralph Kleiner, Mathieu Frechin, Ya-Ming Hou, Hubert Becker, Yuzuru Itoh, Frédéric Fischer, Osamu Nureki

Department of Biochemistry and Molecular Biology Faculty Papers

Ergosteryl-3β-O-L-aspartate synthase (ErdS) catalyzes tRNA-dependent aspartylation of ergosterol, a lipid essential for fungal cell membrane integrity. However, the functional significance of ergosteryl-aspartate and the molecular mechanisms underlying its synthesis remain unclear. Here, we show that ErdS localization is highly dynamic and that Erg-Asp is required for proper hyphal growth, sporulation, and spore germination, and likely influences stress tolerance. The cryo-electron microscopy structure of ErdS revealed an unprecedented sterol-binding pocket. In addition, the structures in complex with a non-hydrolyzable Asp-N-tRNAAsp show a tRNA-guided intramolecular aminoacyl transfer mechanism between two functional domains of the enzyme. The CCA end of tRNAAsp undergoes a …

Development Of A Second-Generation Rarα Selective Antagonist As An Orally Bioavailable, Effective, Safe, And Reversible Male Contraceptive, Rui Shi, Kristen John, Xuan Qin, Ehfazul Haque, Taimeng Liang, Narsihmulu Cheryala, Feng Li, Henry L Wong, Gunda I Georg

Faculty, Staff and Students Publications

We report the design and SAR studies of benzopyran-, benzofuran-, and benzothiophene-derived inhibitors of the retinoic acid receptor alpha (RARα) for male contraception. SAR studies identified critical features influencing activity, such as the optimal positioning of antagonism moieties and substituents, leading to the discovery of (S)-4-(5-(2,8-dimethyl-5-(p-tolyl)-2H-chromen-3-yl)-1H-pyrrol-2-yl)­benzoic acid (compound 23). Compound 23 is a highly potent RARα inhibitor (IC50 = 0.051 nM) with excellent selectivity (>1650-fold over RARβ and >1960-fold over RARγ) and ADMET properties. Compound 23 is orally bioavailable and reduces sperm counts in mice for a full male contraceptive effect …

Pregnancy Outcomes After In Utero Exposure To Immune Checkpoint Inhibitors, Morgan Bou Zerdan, Bruna Kfoury, Eliane Aoun, Sarah Diane Hmaidan, Roni Nitecki Wilke, Jeffrey A How, Terri L Woodard, Pamela T Soliman, Laurie J Mckenzie

Faculty, Staff and Students Publications

Importance: Immune checkpoint inhibitors (ICIs) have transformed the management of cancers affecting reproductive-age patients, yet their impact on pregnancy outcomes remains incompletely understood. We describe two cases of maternal and fetal outcomes associated with ICI exposure during pregnancy and present a comprehensive literature review.

Methods: A retrospective chart review was conducted at MD Anderson Cancer Center (1 January 2015 to 31 December 2024) to identify patients exposed to ICIs during pregnancy. Clinical data including cancer type, treatment timing, pregnancy course, and maternal and neonatal outcomes were collected. A narrative literature review was also performed using PubMed to identify reported cases …

The 2026 Fifa World Cup: Communicable Disease Risks And Advice For Visitors To Canada, The United States, And Mexico, Alfonso J Rodriguez-Morales, Ivan Arturo Rodríguez-Sabogal, Beatriz Elena Porras-Pedroza, Álvaro A Faccini-Martínez, Daniel Grisales-Nieto, Florencia Escarrá, Pasesa Pascuala Quispe-Torrez, Francisco Javier Membrillo, Tomás Orduna, Susana Lloveras, Tânia S S Chaves, Miguel M Cabada, Cecilia Perret, René Echavarría, Ana F Ribeiro, Melinda Tanabe, Fernando Bazzino, Maximiliano Ramirez, Baruch Diaz, Karen Mirna Loro Morejón, Karen Daly, Reinaldo Rosas, Maria Belen Lopez, Cristina Miranda, Marisa Liliana Fernandez, Yasemin Özsürekçi, Wasin Matsee, Yenddy Carrero, Cristian Biscayart, Sergio Cimerman, Maria L Avila-Aguero, Roberto Debbag, Jose Brea, Alejandro Risquez, Jaime David Acosta-España, Rolando Ulloa-Gutierrez, Carlos Espinal, Carlos N Torres-Martinez, Marta González-Sanz, Aula Abbara, Jill Weatherhead, Mario Masana

Faculty, Staff and Students Publications

No abstract provided.

Unbiased Niche Labeling Maps Immune-Excluded Niche In Bone Metastasis, Zhan Xu, Fengshuo Liu, Yunfeng Ding, Tianhong Pan, Yi-Hsuan Wu, Yujiao Han, Jun Liu, Igor L Bado, Weijie Zhang, Ling Wu, Yang Gao, Xiaoxin Hao, Liqun Yu, Xuan Li, David G Edwards, Hilda L Chan, Sergio Aguirre, Michael Warren Dieffenbach, Elina Chen, Siyue Wang, Yichao Shen, Dane Hoffman, Luis Becerra Dominguez, Charlotte Helena Rivas, Xiang Chen, Hai Wang, Yibin Kang, Zbigniew Gugala, Robert L Satcher, Xiang H-F Zhang

Faculty, Staff and Students Publications

Metastatic cancer cell fate is shaped by the local microenvironment niches. To unbiasedly define the cellular and molecular features of metastatic niches, we developed sortase A-based microenvironment niche tagging (SAMENT), which selectively labels cells encountered by cancer cells during metastasis. Applying SAMENT across multiple cancer models and target organs revealed shared niche features, including macrophage enrichment and T cell depletion, alongside marked organ-specific phenotype heterogeneity in niche macrophages. In bone, metastatic niches are enriched for macrophages expressing estrogen receptor alpha (ERα) with active ERα signaling. Conditional deletion of Esr1 in macrophages significantly impaired bone colonization by enabling T cell infiltration. …

Icam1high Neutrophils Sculpt Tumor Evolution And Metastasis Through Symbiotic Adhesion And Reverse Migration, Ling Wu, Zhan Xu, Jun Wang, Fengshuo Liu, Yunfeng Ding, Yang Gao, Siyue Wang, Jun Liu, Hilda L Chan, Weiguo Wu, Yi-Hsuan Wu, Liqun Yu, Xiaoxin Hao, Xuan Li, David G Edwards, Cher Sha, Tobie D Lee, Nan Guan, Sergio Aguirre, Luis Becerra-Dominguez, Dane Hoffman, Xiang Chen, Charlotte Helena Rivas, Xiaoyuan G Yan, Igor L Bado, Weijie Zhang, Qian Zhu, Arun Sreekumar, Robert L Satcher, Xiang H-F Zhang

Faculty, Staff and Students Publications

Neutrophils are a prominent component of the tumor microenvironment that can have both pro- and anti-tumor functions. By analyzing neutrophils across different human cancers, we revealed an ICAM1high subset enriched in the tumor microenvironment, which were also observed in murine triple negative breast cancer (TNBC) models. ICAM1high neutrophils exhibited an enhanced capacity for cell-cell adhesion specifically with tumor cells retaining epithelial features, and this adhesion conferred mutual advantages to both cell types. In contrast, cancer cells with mesenchymal-like phenotypes were vulnerable to neutrophil-mediated cytotoxicity due to decreased cell adhesion and elastase resistance. These opposite effects drove tumor evolution toward a …

Seaweed-Derived Bioactives: A Promising Source Of Novel Therapeutics, Aida H. Shobier, Sahar W.M. Hassan, Safaa A. Abdel Ghani

Blue Economy

The marine environment provides bioactive natural products with unique structures that are absent in terrestrial compounds. This review aims to provide a thorough overview of key studies on bioactives derived from seaweeds. It focuses on their potential to address common diseases such as microbial infections, diabetes, oxidative stress, inflammation, viral infections, cancer, immune disorders, and Alzheimer's disease as well as their potential use in drug delivery systems. The bioactive compounds found in seaweeds belong to various chemical classes, with the largest proportion being polysaccharides, lipids, proteins, phenolics, pigments, terpenoids, alkaloids, and sterols. These compounds possess significant pharmacological potential. …

The Applicability Of A Scale On Self-Regulated Writing Strategies In English For High School Students, Teresa Angelina Kaluge, Sisilia Setiawati Halimi

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Writing appeared to be crucial in learning foreign languages. This study aimed at examining the applicability of a measure on self-regulated writing strategies in terms of its psychometric properties. The scale items were designed from theoretical foundations and previous relevant studies. Questionnaires were distributed online to high school students, collected and analyzed as many as 106. Correlation, confirmatory factor analyses, and calculating Cronbach’s alpha were carried out to make sure the applicability of the scale. The findings showed five main constructs to be applicable. They were self-initiating, planning, text-generating, revising, and acting on feedback.

Developing Scientific Article Writing Materials Using A Hybrid Learning Approach: Insights From An Indonesian Language For Foreign Speakers (Bipa) Program, Ah. Rofiuddin, Didin Widyartono, Gatut Susanto, David Pickus

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aims to develop learning materials for writing scientific articles for international students using the hybrid learning approach. This approach was chosen by utilizing the advantages of offline classes combined with online classes. This approach is in accordance with the characteristics of students as millennials. For product development, we used a method consisting of product design, product design, production, and product testing. In the end, we produced learning materials to write scientific articles packaged in the form of a module of writing process-genre-based scientific articles with a hybrid learning approach for international students. The module consists of the debriefing …

Mapping Arabic Calligraphy Education Research Structure: A Bibliometric Analysis Between 2016 And 2021 Using Vosviewer, Nurul Murtadho, Mohammad Dawood

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The purpose of this study is to present a bibliometric analysis of Arabic calligraphy research from the Scopus database from 2016 to 2021. This study identified 43 English documents for further analysis based on the query used and the document screening stages. In this study, Vosviewer was used to visualize the data, and Harzing's Publish or Perish is used to harvest data, calculate metrics, and analyze citations. According to our findings, Arabic calligraphy research publications are increasing, with the peak occurring in 2019, including in terms of citations. The findings indicate that research in language and arts is closely related …