Digital Commons Network^™

Genomic Insights For Personalised Care In Lung Cancer And Smoking Cessation: Motivating At-Risk Individuals Toward Evidence-Based Health Practices, Tony Chen, Giang Pham, Louis Fox, Nina Adler, Xiaoyu Wang, Jingning Zhang, Jinyoung Byun, Younghun Han, Gretchen R B Saunders, Dajiang Liu, Michael J Bray, Alex T Ramsey, James Mckay, Laura J Bierut, Christopher I Amos, Rayjean J Hung, Xihong Lin, Haoyu Zhang, Li-Shiun Chen

Faculty, Staff and Students Publications

BACKGROUND: Lung cancer and tobacco use pose significant global health challenges, necessitating a comprehensive translational roadmap for improved prevention strategies such as cancer screening and tobacco treatment, which are currently under-utilised. Polygenic risk scores (PRSs) may further motivate health behaviour change in primary care for lung cancer in diverse populations. In this work, we introduce the GREAT care paradigm, which integrates PRSs within comprehensive patient risk profiles to motivate positive health behaviour changes.

METHODS: We developed PRSs using large-scale multi-ancestry genome-wide association studies and standardised PRS distributions across all ancestries. We validated our PRSs in 561,776 individuals of diverse ancestry …

Modeling Antisense Oligonucleotide Therapy In Mecp2 Duplication Syndrome Human Ipsc-Derived Neurons Reveals Gene Expression Programs Responsive To Mecp2 Levels, Sameer S Bajikar, Yehezkel Sztainberg, Alexander J Trostle, Harini P Tirumala, Ying-Wooi Wan, Caroline L Harrop, Jesse D Bengtsson, Claudia M B Carvalho, Davut Pehlivan, Bernhard Suter, Jeffrey L Neul, Zhandong Liu, Paymaan Jafar-Nejad, Frank Rigo, Huda Y Zoghbi

Faculty, Staff and Students Publications

Genomic copy-number variations (CNVs) that can cause neurodevelopmental disorders often encompass many genes, which complicates our understanding of how individual genes within a CNV contribute to pathology. MECP2 duplication syndrome (MDS or MRXSL in OMIM; OMIM#300260) is one such CNV disorder caused by duplications spanning methyl CpG-binding protein 2 (MECP2) and other genes on Xq28. Using an antisense oligonucleotide (ASO) to normalize MECP2 dosage is sufficient to rescue abnormal neurological phenotypes in mouse models overexpressing MECP2 alone, implicating the importance of increased MECP2 dosage within CNVs of Xq28. However, because MDS CNVs span MECP2 and additional genes, we generated human …

Relajo In Plato’S Symposium, Sophia A. Stone

Faculty and Staff Publications & Presentations

No abstract provided.

Unlocking Intracellular Oncology Targets: The Unique Role Of Antibody-Based T-Cell Receptor Mimic (Tcrm) Therapeutics In T-Cell Engagers (Tces) And Antibody-Drug Conjugates (Adcs), Jeffrey Molldrem, Dongxing Zha

Faculty, Staff and Student Publications

Effectively targeting intracellular tumor-associated proteins presents a formidable challenge in oncology, as they are traditionally considered inaccessible to conventional antibody-based therapies and CAR-T cell therapies. However, recent advancements in antibody engineering have revolutionized this field, offering promising new strategies to combat cancer. This review focuses on the innovative use of T-cell receptor mimic (TCRm) antibodies within the therapeutic frameworks of T-cell engagers (TCE) and antibody-drug conjugates (ADCs). TCRm antibodies, designed to recognize peptide-MHC complexes rather than cell surface proteins, integrate the capacity of T-cells to reach intracellular targets with the unique strengths of antibodies. When incorporated into T-cell engaging therapeutics, …

Ophthalmology Career Choices Among Medical Students In Africa: A Cross-Sectional Survey Of 36 Countries, Alec Bernard, Kathryn Flaharty, Dawit Mengesha, Nina Tiertoore, Abdi Tolera, Hellen Wubishet, Tadael Gebeyehu, Hamdi Abdullahi, Amani Abdu, Yesuf Adem, Evan Mullen, Karl Golnik, Geoff Tabin

Journal of Academic Ophthalmology

Purpose To explore the factors influencing medical students' choice of ophthalmology as a specialty in Africa.

Design This was a cross-sectional, mixed methods survey study involving medical students in 36 African countries.

Methods The multi-center cross-sectional survey study was conducted between June and October 2023 explored factors influencing medical students' choice of ophthalmology as a specialty. It involved medical students enrolled in 152 medical schools across 36 African countries. Convenience and snowball sampling was used with dissemination through social media platforms. The questionnaire explored factors influencing their choice of ophthalmology, including demographics, academic and personal interests, clinical exposure, lifestyle factors, …

Impact Of Free Eye Clinic Participation On Medical Students’ Ophthalmic Knowledge, Perceptions Of Ophthalmology, And Perceptions Of Underrepresented Patient Populations, Noor-Us-Sabah Ahmad, Aditya Somisetty, Nicole Hehr, Wisam Najdawi, Hend Al-Kaylani, Lydia Yang, Pavlina S. Kemp, Andrew E. Pouw

Journal of Academic Ophthalmology

Objectives:

To evaluate the impact of volunteering at a free eye clinic on medical students’ ophthalmic knowledge, perceptions of ophthalmology and of underrepresented patient populations.

Methods:

A cross-sectional survey was developed and distributed by email to both volunteers and non-volunteers at the Iowa City Free Medical Clinic’s Free Eye Clinic (FEC) between July and August 2023. Study participants were medical students both enrolled at the Carver College of Medicine and former students who had recently graduated. Survey questions included an assessment of ophthalmic knowledge, respondent perceptions of the field of ophthalmology, and respondent perceptions of underserved populations and …

A Bibliometric Analysis Of Social Perception And Academic Trends On Gender And Race In Ophthalmology, Hassaam S Choudhry, Jason Dossantos, Siddhant Kumarapuram, Helen N Nguyen, Hannaan S Choudhry, Aakriti G Shukla, Angela Elam, Mona A Kaleem

Journal of Academic Ophthalmology

Background: Gender and race disparities in ophthalmology have gained increased attention in recent years due to their clinical and societal significance. This study aimed to assess the number of publications related to gender and race in ophthalmology, factors associated with increased scholarly impact, determine journals with the greatest output, and identify leading institutions and countries contributing to this literature.

Methods: This bibliometric analyzed published literature from January 2000 to June 2022. Article publication year, authors, journal, citations, institution, and country were collected. Focuses included history/biographies, career analysis, pay gap, recruitment/retention, scholarly productivity, training, and disparities. Citations per year, …

Student Perceptions Of A Novel No-Cost Mobile Application For Ophthalmic History And Physical Examination, Soryan Kumar, Anagha Lokhande, Spandana Jarmale, Arnav Kumar, Samantha Rosenthal, Grayson W. Armstrong, Michael Migliori, Jamie Schaefer

Journal of Academic Ophthalmology

Background: Mobile applications have shown promise in enhancing medical trainee performance. In ophthalmology, a comprehensive mobile app can streamline the trainee education process by providing guidance for patient intake. Language barriers pose additional challenges impacting the quality of care for Spanish-speaking patients; literature has documented the adverse impacts of inadequate translation on quality of medical care for both trainees and patients. We aim to develop a free mobile application to guide medical trainees through the ophthalmic patient intake process and assist with Spanish-language translation.

Methods: We developed EyeCheck as a free mobile application for ophthalmology trainee education with …

Community Outreach Vision Screenings With Student-Led Eye Health Education Improves Student Eye Health Knowledge And Ophthalmic Health Disparities Awareness, Tannia M. Rodriguez, Karim Dirani, Samantha M. Arsenault, Ryan Lee Freedman, John-Michael Guest, Kathleen George, Collin Richards, Leo Hall, Mark S. Juzych, Anju Goyal

Journal of Academic Ophthalmology

BACKGROUND: The high prevalence of vision impairment and discordant lack of eye care utilization makes it essential to develop effective avenues to educate the future physician work force regarding basic eye health knowledge and ophthalmic health disparities. The public is often not aware that blinding eye diseases can begin asymptomatically. It is important for medical students to understand basic eye health knowledge, such as blinding eye diseases can begin asymptomatically. The purpose of this study was to assess the impact of an eye health knowledge 5-Point Teaching Intervention (5PTI) and structured patient intake form on student eye health knowledge and …

Otherness, Survival And Hope: Pedagogies In Popular Media [Dialogue: The Interdisciplinary Journal Of Popular Culture And Pedagogy Volume 6, Issue 3 (December 2019)], Anna S. Cohenmiller

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Otherness, Survival and Hope: Pedagogies in Popular Media [Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy Volume 6, Issue 3 (December 2019)]

Editorial

Teaching and Learning about Otherness in Popular Culture, Anna S. CohenMiller

Section 1

Learning about Otherness within Formal Education “I am a Conversation”: Media Literacy, Queer Pedagogy, and Steven Universe in College Curriculum, Misty Thomas

Using News to Start Class: How Small Daily Interactions Affect Larger Classroom Interactions, Laura Dumin

Section 2

Informal Learning as Survival “No te voy a dejar nunca”: Culture and Second Language Acquisition for Survival in Fear the Walking Dead, Sharon …

Zombie Literature: Analyzing The Fear Of The Unknown Through Popular Culture, T. Hnter Strickland

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

This paper will focus on how the rise in popularity of zombie literature in the 21st century is reflective of a western cultural need to address the fear of the unknown through popular culture. Through the flesh-eating zombie, we enter a parallel world where everything familiar in our communities becomes evil. The genre reflects the fear in Western society of the neighbor who has turned against you, survival in the midst of government collapse, and the monster within. Zombie fantasy literature allows society a venue to deconstruct what is known while dealing with these fears and the unbridled hate of …

Consider The Dementor: Discipline, Punishment, And Magical Citizenship In Harry Potter, Tracy Bealer

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

In his 2004 essay “Consider the Lobster”, David Foster Wallace investigated the ethics of boiling alive an aesthetically unappealing, yet sentient and perceiving, creature to augment the pleasure of a human consumer. In the Potterverse, dementors are described by our human heroes as “terrible things” with “rotting” bodies, “unseen” mouths, and characterized as “among the foulest creatures that walk this earth” . Their occupation as guards of Azkaban Prison does little to improve their reputation among wizard-kind. However, how much of the dementors’ evil is ontological? Is it possible that these beings have been actively constructed as villains by wizarding …

“No Te Voy A Dejar Nunca”: Culture And Second Language Acquisition For Survival In Fear The Walking Dead, Sharon M. Nuruddin

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Popular culture reinforces and shapes the beliefs and values of the individual, the community, and the masses. It can also transmit hidden messages about aspects of human behavior that are reiterated in scholarly research. In the field of education, particularly in world language teacher education, film and television can be used as an effective tool for examining how we acquire a second language. Using a symbolic convergence theory perspective (SCT) (Bormann, 1972), I employ Sellnow’s (2014) three-step process for the rhetorical analyses of mediated popular culture texts to reveal “covert messages” (p. 9) within the popular American Movie Channel (AMC) …

Using News To Start Class: How Small Daily Interactions Affect Larger Classroom Interactions, Laura M. Dumin

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

In 2013, I added an extra credit assignment to my freshmen composition classes encouraging students to bring in news stories each class period; this assignment was designed to encourage students to be more willing to participate in classroom discussions. We then spent the first few minutes of each class discussing the stories they brought. After using this assignment for a few years, I had anecdotal evidence to suggest that my students were generally more talkative in class after the first week or two of sharing news. These experiences made me want to see if I could measure some change or …

“I Am A Conversation”: Media Literacy, Queer Pedagogy, And Steven Universe In College Curriculum, Misty Thomas

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

The recent cartoon show on Cartoon Network Steven Universe allows for the blending of both queer theory and media literacies to create a pedagogical space for students to investigate and analyze not only queerness, but also normative and non-normative identities. This show creates characters as well as relationships that both break with and subvert what would be considered traditional masculine and feminine identities. Additionally, Steven Universe also creates a space where sexuality and transgender bodies are represented. This paper demonstrates both the presence of queerness within the show and the pedagogical implications for using this piece of media within a …

Criminals As Heroes: Problems And Pedagogy In Popular Culture [Dialogue: The Interdisciplinary Journal Of Popular Culture And Pedagogy Volume 6, Issue 2 (August 2019)], Anna S. Cohenmiller, Kelli Bippert

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Criminals as Heroes: Problems and Pedagogy in Popular Culture [Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy Volume 6, Issue 2 (August 2019)]

Editorial

Critically Evaluating the Fictional World through Popular Culture, Kelly Bippert and Anna CohenMiller

Guest Editorial

What Hot Criminals, Anti-Heroes, and Bob Dylan Can Teach Us, Kathryn (“Kate”) Lane and Roxie James

Articles

If Androids Dream, Are They More Than Sheep?: Westworld, Robots and Legal Rights, Amanda DiPaolo

Nature vs. Nurture in Albuquerque: What Breaking Bad and Better Call Saul Teach Us About How We Talk about Criminals, Max Romanowski

Breaking the Rules: Playing Criminally in …

Amc’S Infamous Criminal Partnerships: Suppressing The Female Antihero, Melissa Vosen Callens

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

This paper explores the limited number of female antiheroes in AMC’s critically acclaimed drama series. Using a feminist lens, the author argues that audiences have failed to embrace female characters on AMC as antiheroes, particularly when they are in romantic relationships with male antiheroes, for three primary reasons. First, female characters often challenge binary thinking, and thus, gender role stereotypes. Rather than exhibiting passive, yet nurturing characteristics, characteristics often associated with femininity and motherhood, female characters within the dataset frequently challenge their partners and exert their dominance. Second, writers often fail to fully develop female characters. The absence of their …

Bad Girls: Agency, Revenge, And Redemption In Contemporary Drama, Courtney Watson

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Cultural movements including #TimesUp and #MeToo have contributed momentum to the demand for and development of smart, justified female criminal characters in contemporary television drama. These women are representations of shifting power dynamics, and they possess agency as they channel their desires and fury into success, redemption, and revenge. Building on works including Gillian Flynn’s Gone Girl and Netflix’s Orange is the New Black, dramas produced since 2016—including The Handmaid’s Tale, Ozark, and Killing Eve—have featured the rise of women who use rule-breaking, rebellion, and crime to enact positive change.

Vol. 35, No. 12 - Whole No. 201, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 35, No. 10 - Whole No. 199, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 35, No. 9 - Whole No. 198, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 35, No. 7 - Whole No. 196, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 35, No. 6 - Whole No. 195, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 35, No. 5 - Whole No. 194, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 35, No. 3 - Whole No. 192, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 35, No. 2 - Whole No. 191, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 35, No. 1 - Whole No. 190, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Reinterpretation: Situating Culture From Pedagogy To Politics [Dialogue: The Interdisciplinary Journal Of Popular Culture And Pedagogy, Volume 6, Issue 1 (February 2019)], Anna S. Cohenmiller

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Reinterpretation: Situating Culture from Pedagogy to Politics [Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy, Volume 6, Issue 1 (February 2019)]

Editorial

Reinterpretations of Popular Culture and Pedagogy, Anna S. CohenMiller

Articles

Scarlett O’Hara, Solomon Northrup, and Ta-Nehisi Coates: Helping Students Grasp the Relationship between Popular Culture and Contemporary Racial Politics, Allison Rank

“Every Time I Write a Rhyme / These People Think It’s a Crime”: Persona Problems in Catullus and Eminem, Jesse Weiner

Making the Case for Teaching Character Change in Complex TV: The Closer and Major Crimes, Emily Hoffman

Human Sacrifice and Propaganda in Popular Discourse: More …

Studying Silence In Popular Culture, Kathy Merlock Jackson, Terry Lindvall

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

This article explains the impetus for and execution of a team-taught, interdisciplinary class in silence using popular culture materials and practices, such as silent film, music, meditation, and mime. The course identifies individuals as possessing characteristics of introversion and extraversion and explores the role of silence in the modern world, incorporating the following: (1) Foundations for the Study of Silence, (2) The History of Silence, (3) The Role of Silence in Spirituality, Creativity and Reflection, (4) Silence in Communication Study, (5) Silent Film and Silence in Film, (6) The Role of Silence in a Highly Technological, Mediated World, and (7) …

Making The Case For Teaching Character Change In Complex Tv: The Closer And Major Crimes, Emily C. Hoffman

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Jason Mittel’s 2015 book Complex TV: The Poetics of Contemporary Television Storytelling offers enough material to sustain a semester-long undergraduate course. Because of its approachability and students’ interest in discussing characters, his chapter devoted to viewers’ parasocial relationships and characters’ potential for change is among the most teachable. However, teaching complex television that relies on intensely serialized story elements can make choosing televisual texts for study and discussion challenging. Therefore, series that skew episodic yet still incorporate serial elements, like police procedurals, can prove to be a practical alternative for classroom study. This article describes how using the interrelated …