Digital Commons Network^™

Crème De La Conference: 8th World Congress Of Pediatric Cardiology And Cardiac Surgery-Wcpccs 2023, Carissa M. Baker-Smith, Liesl Zühlke, Jennifer Co-Vu, Shubhika Srivastava, Renelle George, Shelby Kutty, Ali N. Zaidi, David J. Goldberg, Erica D. Sood, Kathryn M. Dodds, David S. Cooper, Mitchel I. Cohen, Gil Wernovsky, Jeffrey P. Jacobs

Department of Medicine Faculty Papers

No abstract provided.

Biguanides Antithetically Regulate Tumor Properties By The Dose-Dependent Mitochondrial Reprogramming-Driven C-Src Pathway, Sukjin Yang, Kuldeep S Attri, Songyeon Ahn, Divya Murthy, Tagari Samanta, Debasmita Dutta, Meron Ghidey, Somik Chatterjee, Seung Yeop Han, Diego A Pedroza, Abha Tiwari, Joyce V Lee, Caitlin Davis, Shuting Li, Vasanta Putluri, Chad J Creighton, Nagireddy Putluri, Lacey E Dobrolecki, Michael T Lewis, Jeffrey M Rosen, José N Onuchic, Andrei Goga, Benny Abraham Kaipparettu

Faculty, Staff and Students Publications

The biguanide metformin attenuates mitochondrial oxidation and is proposed as an anti-cancer therapy. However, recent clinical studies suggest increased proliferation and fatty acid β-oxidation (FAO) in a subgroup of patients with breast cancer (BC) after metformin therapy. Considering that FAO can activate Src kinase in aggressive triple-negative BC (TNBC), we postulate that low-dose biguanide-driven AMPK-ACC-FAO signaling may activate the Src pathway in TNBC. The low bioavailability of metformin in TNBC xenografts mimics metformin's in vitro low-dose effect. Pharmacological or genetic inhibition of FAO significantly enhances the anti-tumor properties of biguanides. Lower doses of biguanides induce and higher doses suppress Src …

Deep5mc: Predicting 5-Methylcytosine (5mc) Methylation Status Using A Deep Learning Transformer Approach

Faculty, Staff and Student Publications

DNA methylations, such as 5-methylcytosine (5mC), are crucial in biological processes, and aberrant methylations are strongly linked to various human diseases. Genomic 5mC is not randomly distributed but exhibits a strong association with genomic sequences. Thus, various computational methods were developed to predict 5mC status based on DNA sequences. These methods generated promising achievements and overcome the limitations of experimental approaches. However, few studies have comprehensively investigated the dependency of 5mC on genomic sequences, and most existing methods focus on specific genomic regions. In this work, we introduce Deep5mC, a deep learning transformer-based method designed to predict 5mC methylations. Deep5mC …

The Use Of Antiepileptic Drugs And Their Effects In Pregnancy, Pinar Öztürk, Ali̇ Turhan Çağlar

Turkish Journal of Medical Sciences

Background/Aim: Epilepsy is one of the most common chronic neurological diseases. Epilepsy can affect the entire life, including childbearing age. It is estimated that epileptic women give three to five births per thousand births. Although the use of antiepileptic drugs (AEDs) during pregnancy has been associated with major congenital malformations in the fetus, many patients cannot discontinue the drugs before pregnancy due to the risk of seizures that may harm the mother as well as the children. In this study, our aim is to examine the follow-up findings of pregnant women who are epileptic and use AEDs during pregnancy and …

Rice Cultivar Tolerance To Preemergence- And Postemergence-Applied Fluridone, Maria Carolina Souza, Jason K. Norsworthy, Pamela Carvalho-Moore, Amar J. Godar, Samuel B. Fernandes, Thomas R. Butts

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Fluridone was registered for use in rice production in 2023, offering a new herbicide site of action for growers. However, little information is available on the degree of rice tolerance to this herbicide. Field experiments conducted in 2022 and replicated in 2023 near Colt, AR, evaluated the tolerance of 12 rice cultivars to fluridone, applied preemergence or at the 3-leaf growth stage, in separate experiments. Each experiment consisted of one cultivar. Fluridone rates included 0, 168 (1 x label rate), and 336 (2 x label rate) g ai ha-1 in all experiments. Visible injury varied between years in all experiments, …

Trends In Ischemic Stroke Hospitalization And Outcomes In The United States Pre- And Peri-Covid-19 Pandemic: A National Inpatient Sample Study, Louise D Mccullough, Mohammed Ismail, Afshin A Divani

Faculty, Staff and Student Publications

Background/Objectives: The COVID-19 pandemic impacted healthcare systems globally, disrupting the management and treatment of acute ischemic stroke (AIS). Understanding how AIS admissions, treatments, and outcomes were affected is critical for improving stroke care in future crises. The objective of this work was to assess the COVID-19 pandemic's impact on AIS admissions, treatment patterns, complications, and patient outcomes in the U.S. from 2016 to 2021, focusing on differences between pre-pandemic (2016-2019) and peri-pandemic (2020-2021) periods.

Methods: This is a retrospective cohort study using the National Inpatient Sample (NIS) database, analyzing weighted discharge records of AIS patients over six years. Data encompass …

An Integrative Multiparametric Approach Stratifies Putative Distinct Phenotypes Of Blast Phase Chronic Myelomonocytic Leukemia, Kristian Gurashi, Yu-Hung Wang, Fabio M R Amaral, Katherine Spence, Rachel Cant, Chien-Chin Lin, David C Wedge, Guillermo Montalban-Bravo, Simona Colla, Hwei-Fang Tien, Tim C P Somervaille, Kiran Batta, Daniel H Wiseman

Faculty, Staff and Student Publications

Approximately 30% of patients with chronic myelomonocytic leukemia (CMML) undergo transformation to a chemo-refractory blastic phase (BP-CMML). Seeking novel therapeutic approaches, we profiled blast transcriptomes from 42 BP-CMMLs, observing extensive transcriptional heterogeneity and poor alignment to current acute myeloid leukemia (AML) classifications. BP-CMMLs display distinctive transcriptomic profiles, including enrichment for quiescence and variability in drug response signatures. Integrating clinical, immunophenotype, and transcriptome parameters, Random Forest unsupervised clustering distinguishes immature and mature subtypes characterized by differential expression of transcriptional modules, oncogenes, apoptotic regulators, and patterns of surface marker expression. Subtypes differ in predicted response to AML drugs, validated ex vivo in …

Natural And Bioengineered Extracellular Vesicles In Diagnosis, Monitoring And Treatment Of Cancer, Xin Luo, Kathleen M Mcandrews, Raghu Kalluri

Faculty, Staff and Student Publications

Extracellular vesicles (EVs) are cell derived nanovesicles which are implicated in both physiological and pathological intercellular communication, including the initiation, progression, and metastasis of cancer. The exchange of biomolecules between stromal cells and cancer cells via EVs can provide a window to monitor cancer development in real time for better diagnostic and interventional strategies. In addition, the process of secretion and internalization of EVs by stromal and cancer cells in the tumor microenvironment (TME) can be exploited for delivering therapeutics. EVs have the potential to provide a targeted, biocompatible, and efficient delivery platform for the treatment of cancer and other …

Single-Cell Analysis Of Neoplastic Plasma Cells Identifies Myeloma Pathobiology Mediators And Potential Targets, Luz Yurany Moreno Rueda, Hua Wang, Keiko Akagi, Minghao Dang, Amishi Vora, Hans C Lee, Pei Lin, David E Mery, Fenghuang Zhan, John D Shaughnessy, Qing Yi, Yang Song, Bo Jiang, Maura L Gillison, Sheeba K Thomas, Donna M Weber, Lixia Diao, Jing Wang, Isere Kuiatse, Elisabet E Manasanch, David E Symer, Robert Z Orlowski

Faculty, Staff and Student Publications

Multiple myeloma is a clonal plasma cell (PC) dyscrasia that arises from precursors and has been studied utilizing approaches focused on CD138+ cells. By combining single-cell RNA sequencing (scRNA-seq) with scB-cell receptor sequencing (scBCR-seq), we differentiate monoclonal/neoplastic from polyclonal/normal PCs and find more dysregulated genes, especially in precursor patients, than we would have by analyzing bulk PCs. To determine whether this approach can identify oncogenes that contribute to disease pathobiology, mitotic arrest deficient-2 like-1 (MAD2L1) and S-adenosylmethionine synthase isoform type-2 (MAT2A) are validated as targets with drug-like molecules that suppress myeloma growth in preclinical models. Moreover, functional studies show a …

Iroc Phantoms Accurately Detect Mlc Delivery Errors, Sharbacha S Edward, Julianne M Pollard-Larkin, Peter A Balter, Rebecca M Howell, Christine B Peterson

Faculty, Staff and Student Publications

Purpose: We evaluated the impact of random and whole-bank multileaf collimator (MLC) delivery errors on dosimetric delivery accuracy in the Imaging and Radiation Oncology Core (IROC) phantom audits, as well as differences in delivery accuracy between the IROC phantom prescription and typical clinical fraction sizes.

Methods and materials: Plans were created for the IROC IMRT head and neck (H&N) and SBRT spine phantoms. MLC leaf errors were introduced into the plans: random shifts between -2 and 2 mm, and whole bank shifts of 0.5, 1, and 2 mm. Plans were recalculated and delivered on a Varian Truebeam, and the log …

Nanrilkefusp Alfa (Sot101), An Il-15 Receptor Βγ Superagonist, As A Single Agent Or With Anti-Pd-1 In Patients With Advanced Cancers, Stephane Champiat, Elena Garralda, Vladimir Galvao, Philippe A Cassier, Carlos Gomez-Roca, Peter Grell, Patricia Lorusso, Romana Mikyskova, Nada Podzimkova, Milan Reinis, Kaissa Ouali, Andreu Schoenenberger, Joachim Kiemle-Kallee, Sascha Tillmanns, Richard Sachse, Ulrich Moebius, Radek Spisek, David Bechard, Lenka Palova Jelinkova, Irena Adkins, Aurelien Marabelle

Faculty, Staff and Student Publications

Nanrilkefusp alfa (nanril; SOT101) is an interleukin (IL)-15 receptor βγ superagonist that stimulates natural killer (NK) and CD8

Mitochondrial Defects And Metabolic Vulnerabilities In Lynch Syndrome-Associated Msh2-Deficient Endometrial Cancer, Mikayla Borthwick Bowen, Brenda Melendez, Qian Zhang, Diana Moreno, Leah Peralta, Collene Jeter, M Anna Zal, Philip L Lorenzi, Kenneth Dunner, Richard K Yang, Russell R Broaddus, Joseph Celestino, Nisha Gokul, Elizabeth Whitley, Deena M Scoville, Tae Hoon Kim, Jae-Wook Jeong, Rosemarie Schmandt, Karen Lu, Hyun-Eui Kim, Melinda S Yates

Faculty, Staff and Student Publications

Lynch syndrome (LS), caused by inherited mutations in DNA mismatch repair genes, including MSH2, carries a 60% lifetime risk of developing endometrial cancer (EC). Beyond hypermutability, mechanisms driving LS-associated EC (LS-EC) remain unclear. We investigated MSH2 loss in EC pathogenesis using a mouse model (PR-Cre Msh2LoxP/LoxP, abbreviated Msh2KO), primary cell lines, human tissues, and human EC cells with isogenic MSH2 knockdown. By 8 months, 58% of Msh2KO mice developed endometrial atypical hyperplasia (AH), a precancerous lesion. At 12-16 months, 50% of Msh2KO mice exhibited either AH or ECs with histologic similarities to human LS-ECs. Transcriptomic profiling of EC from Msh2KO …

Unveiling The Genetic Landscape Of Coronary Artery Disease Through Common And Rare Structural Variants, Adam S Heath, Jai G Broome, Alyna T Khan, Joshua P Lewis, Huichun Xu, May E Montasser, Kellan E Ashley, Natalie R Hasbani, Eric Boerwinkle, Alanna C Morrison, Nathalie Chami, Ron Do, Ghislain Rocheleau, Donald M Lloyd-Jones, Rozenn N Lemaitre, Joshua C Bis, James S Floyd, Gregory L Kinney, Donald W Bowden, Nicholette D Palmer, Emelia J Benjamin, Matthew Nayor, Lisa R Yanek, Brian G Kral, Lewis C Becker, Sharon L R Kardia, Jennifer A Smith, Lawrence F Bielak, Arnita F Norwood, Yuan-I Min, April P Carson, Wendy S Post, Stephen S Rich, David Herrington, Xiuqing Guo, Kent D Taylor, Joann E Manson, Nora Franceschini, Katherine S Pollard, Braxton D Mitchell, Ruth J F Loos, Myriam Fornage, Lifang Hou, Bruce M Psaty, Kendra A Young, Elizabeth A Regan, Barry I Freedman, Ramachandran S Vasan, Daniel Levy, Rasika A Mathias, Patricia A Peyser, Laura M Raffield, Charles Kooperberg, Alex P Reiner, Jerome I Rotter, Goo Jun, Paul S De Vries, Themistocles L Assimes

Faculty, Staff and Student Publications

Background: Genome-wide association studies have identified several hundred susceptibility single nucleotide variants for coronary artery disease (CAD). Despite single nucleotide variant-based genome-wide association studies improving our understanding of the genetics of CAD, the contribution of structural variants (SVs) to the risk of CAD remains largely unclear.

Method and results: We leveraged SVs detected from high-coverage whole genome sequencing data in a diverse group of participants from the National Heart Lung and Blood Institute's Trans-Omics for Precision Medicine program. Single variant tests were performed on 58 706 SVs in a study sample of 11 556 CAD cases and 42 907 controls. …

The Geography Of The European Dreadnought Race: 1884-1919, William D. Walters, Jr.

The Geographical Bulletin

The launching of HMS Dreadnought in 1906 is sometimes regarded as the start of the warship building race preceding World War One and is often seen as one of the causes of that war. In fact, the European battleship building race goes back to the 1880s. Most of the countries of Europe participated in some way in this race, which involved significant transfer of technology from the more developed to the less developed countries of Europe. Spain, Italy and Russia received significant aid from armaments firms in northern and western Europe. During the period before the war, battleships dominated naval …

Thematic Innovation On The North American Colonial Frontier: Comparisons Of The Four Historic Maps Of Fort Michilimackinac, Michigan 1749-1769, Richard Alan Sambrook

The Geographical Bulletin

To date, four historic maps of Fort Michilimackinac, Michigan are recognized: de Lotbiniere's Plan and Description (1749), the Magra Map (1766), the Nordberg Map (1769), and the Crown Collection Map (circa 1766-1769). These maps are all different in a number of important map features, including scale, style, technique, and portrayal of the type and detail of information included on the map, especially the accuracy of the location and size of structures within the fort. This paper also demonstrates the wealth of social, cultural and architectural information contained within the four existing historic maps. In conjunction these maps have both aided …

Volume 34-2 Complete Issue, C. Nicholas Raphael

The Geographical Bulletin

Volume 34-2 Complete Issue

Projections And Perceptions-Editorial Comments. The Changing Importance Of College And University Teaching: The 1960s Versus The 1990s, James O. Wheeler (University Of Georgia), James O. Wheeler

The Geographical Bulletin

Approximately thirty years ago, when I was just starting graduate school in geography, one of the first impressions I gained was the low priority accorded teaching. The emphasis, instead, was on research. The attitude was that anyone could teach but not everyone could do hotshot research. In fact, I got the impression that professors who were so wrapped up in research that their lectures were disorganized and confused were admired more than professors who did little or no research but whose lectures were superb. (There were, of course, inexplicably, those rare professors who did both remarkably well.) In general, poorly …

The Active Voice: One Key To More Effective Geographic Writing, Michael D. Sublett

The Geographical Bulletin

Despite admonitions from grammarians, journal editors, and conference program chairs, many geographers apparently either know not or care not about the advantages of choosing the forceful active voice over the feeble, often anonymous, passive voice. Paired examples of (1) previously published sentences, from geographic sources, containing at least one passive expression and (2) my revisions of the same sentences provide herein illustrative material for authors wishing to activate their prose.

An Economic Location Model For Texas Wineries, Mary Luanne Napton, Darrell E. Napton, James D. Harrison

The Geographical Bulletin

Sunbelt migration and increased per capita wine consumption have stimulated the opening of 27 new wineries in Texas since 1976. Choosing the location of a winery is one of the vintner's most important decisions. A survey of vintners provided a ranking of locational criteria that was used to develop an economic locational model of winery location. A preliminary model was tested and discarded in favor of a more narrowly defined model. Critical marketing locational criteria included proximity to tourist areas, access to grapes, distance from urban areas, access to an interstate highway, and severity of county alcohol laws.

59-1 Complete Issue

Journal of STEM Teacher Education

No abstract provided.

Primary School Teachers' Views On Robotics Supported Stem Applications In Different Countries, Nurettin Can Bodur, Cengiz Tüysüz, Süheyla Didem Bodur

Journal of STEM Teacher Education

In this study, it was aimed to develop out-of-school activity modules for 4th grade primary school students by combining R-STEM approach. It was aimed to investigate the opinions of teachers who implemented modules. In the study, case study from qualitative design was used. Research group, which was designed according to a holistic single case design, consisted of 15 primary school teachers working in different countries. The selection of research group was made using appropriate sampling. Within the scope of the study, five courses were held. Data were collected through individual and focus group interview form. Data were processed through content …

A Call To Threaten Systemic Inequities Through Critical ‎Crosscultural Communicative Competence In Future Teachers: ‎Engaging Els In Stem Using A Critical Conceptual Framework, Abdelilah Salim Sehlaoui, Hassan Zaid

Journal of STEM Teacher Education

This article shares a critical conceptual framework to threaten ‎systemic ‎inequities through computer-assisted language learning (CALL) using a critical ‎crosscultural communicative competence (C⁵) and equity literacy to engage English ‎learners (ELs) in ‎Science, ‎Technology, Engineering, and Mathematics (STEM). The proposed critical conceptual framework is compatible with ways of thinking in STEM-based problem solving (English, 2023). To achieve this goal, a theory adaptation ‎critical research design was used with a sociocultural analysis and a modified transactional ‎epistemology critical approach. The paper argues for building a critical conceptual framework that is based fundamentally on a critical view of equity literacy …

Sex-Based Differences In The Utility And Outcomes Of Left Ventricular Assist Devices, Mirvat Alasnag, Waleed Alhabeeb, Feras Khaliel

Journal of the Saudi Heart Association

The totality of evidence suggests that there remains a significant disparity in the use of left ventricular assist devices (LVADs) and heart transplantation (HT) in women. This disparity persists even after accounting for differences in baseline characteristics, comorbidities, and cardiovascular risk factors between men and women undergoing LVAD implantation as a bridge to HT. Generally, women are less likely to undergo HT, leading to a higher mortality rate in women on the HT waiting list. The differences in risk profiles and device-related complications may account for the sex-related disparities in the assignment of device therapies. These findings warrant an urgent …

A Report On Health Care Access By The United States Citizens., Kelvin Njuki, Emil Agbemade

Data Science and Data Mining

Access to health care is a critical factor in ensuring public health. This study analyzes data from the National Health Interview Survey (NHIS) for the years 2015–2018 to examine the relationship between health care coverage, affordability, and costs among U.S. families. Re-sults indicate that families with at least one member covered by health insurance were more likely to afford medical care and incur lower health care costs. Despite a high proportion of families with health care coverage during this period, the number of insured family members declined over the years. These findings underscore the importance of health care coverage in …

Eng 3401-001 Methods Of Teaching Composition In The Middle And Secondary School, Elizabeth Tacke

Fall 2024

No abstract provided.

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.

Triswinunetr Lobe Segmentation Model For Computing Dir-Free Ct-Ventilation, Gabriela Roque Oliveira Nomura, Aarom T. Luong, Ananya Prakash, Annabelle Alemand, Tanish Bhowmick, Alisa Ali, Jaimie Ren, Basil Rehani, Girish Nair, Richard Castillo, Yevgeniy Vinogradskiy, Edward Castillo

Department of Radiation Oncology Faculty Papers

Purpose: Functional radiotherapy avoids the delivery of high-radiation dosages to high-ventilated lung areas. Methods to determine CT-ventilation imaging (CTVI) typically rely on deformable image registration (DIR) to calculate volume changes within inhale/exhale CT image pairs. Since DIR is a non-trivial task that can bias CTVI, we hypothesize that lung volume changes needed to calculate CTVI can be computed from AI-driven lobe segmentations in inhale/exhale phases, without DIR. We utilize a novel lobe segmentation pipeline (TriSwinUNETR), and the resulting inhale/exhale lobe volumes are used to calculate CTVI. Methods: Our pipeline involves three SwinUNETR networks, each trained on 6,501 CT image pairs …

Elementary Italian Ii, Monica Rossi-Miller

Open Educational Resources

Italian II aims at increasing the student's ability to use basic forms of oral communication in Italian through constant use of the everyday idiom. Carefully graded practice in reading and writing supplement the conversational aspects of the course. We will cover the second half of Italian Espresso 1 that is, chapter 7 through chapter 11, and the accompanying chapters in the workbook. We also will work on vocabulary, grammar, pronunciation, oral comprehension, conversation, spelling and writing. Speaking, oral comprehension, and conversation will be
emphasized.

Italian Culture Through Film, Monica Rossi-Miller

Open Educational Resources

Introduction to important themes of Italian culture by viewing and analyzing
representative Italian films from the post-World War II era to the present. Topics examined include: the Italian family, how World War II has shaped contemporary Italian culture, Italy as a country of emigrants and immigrants, and an examination of religion and the Catholic Church.
This is a Writing Intensive course conducted in English, and all films have English subtitles.

A Writing Intensive Course Specifically is a designated course sections that—in addition to providing the established disciplinary-oriented student outcomes—incorporate approved instructional strategies and course assignments designed to enhance students’ writing …

Culture Of German Speaking Countries, Monica Rossi-Miller

Open Educational Resources

LG401 FNET is a 3 hours, 3 credits course with ENGL101 as a pre or co-requisite. It is an upper level course, however, no previous knowledge in Cultures of German speaking Countries is required, nor any knowledge of German language. The focus will be on cultures of countries in which German is an official language such as Germany, Austria, Switzerland and Liechtenstein. It fulfills 2A of the Common Core, WI (Writing intensive) requirement and Humanities elective.

Description: Students will be exposed to and discuss cultural developments in German-speaking countries including their role in the European Union. They will read …